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Publication numberUS2787268 A
Publication typeGrant
Publication dateApr 2, 1957
Filing dateMar 16, 1956
Priority dateMar 16, 1956
Publication numberUS 2787268 A, US 2787268A, US-A-2787268, US2787268 A, US2787268A
InventorsGreenspan Irving
Original AssigneeGreenspan Irving
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Blood plasma bottle
US 2787268 A
Abstract  available in
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Claims  available in
Description  (OCR text may contain errors)

April 2, 1957 1. GREENSPAN BLOOD PLASMA BOTTLE Filed March 16, 1956 garner/575 M @merza affawvze gxa United States Patent BLOOD PLASMA BOTTLE Irving Greenspan, Skokie, Ill.

Application March 16, 1956, Serial No. 572,035

9 Claims. (Cl. 128-272) This invention relates generally to a container for perishable materials and more particularly is concerned with the construction of a container for blood plasma which is adapted to be used for direct application quickly and without difficulty.

Blood plasma is usually dried, and mixed with water just prior to administration, and considerable difliculty has accompanied the use of the containers which are known, especially for field application. The plasma is perishable, and hence it and a container of water are furnished as two separate parts of a kit. The plasma is in powdered form and packed in vacuum and the water is sterile. The attendant is furnished with a double ended hollow needle. One end must first be inserted into the water bottle cap, and the water bottle is then picked up and the opposite end of the needle inserted into the plasma bottle so that the vacuum in the plasma bottle draws the water through the hollow needle and into contact with the dried plasma to become hydrated. Thereafter, the water bottle is removed and a tube with administering end is attached to the needle now protruding from the plasma bottle. The liquid then flows either by gravity, or through the use of a pump fitted to the administering tube, to the blood vessel of the patient.

The difficulties attendant upon the use of the kit described are manifold:

1. In haste, often the needle will first be inserted into the plasma bottle, whereupon the vacuum is lost and there is no sterile way of admixing the dried plasma and water, and even if there were some way of introducing the water into the plasma bottle, the air sucked in when the vacuum is broken may well have contaminated the plasma. Thus there has been in the past tremendous waste due to errors of personnel and this had been particularly serious in combat, where the attendant may not have much skill along these lines.

2. Bottle breakage is a cause of considerable loss.

3. The kit contains two bottles, and hence is heavy and takes up considerable space.

4. In forced administration, the pump must be fitted to the administering tube and operated continuously by the attendant because small size of the conduit in the needle limits the rate of flow.

This invention alleviates and eliminates the disadvantages of previous methods of administering blood plasma and the principal object of the invention is directed to provision of a structure for a plasma bottle which will eliminate and positively prevent the error of puncturing the wrong bottle with its attendant waste; the provision of a structure which is unbreakable; the provision of a structure for a plasma bottle which is a single unit, light in weight and of small volume; the provision of a plasma bottle with which plasma may be forcibly administered without the need for pumps or other fittings.

Many other objects of the invention will appear as the description proceeds in connection with which I have illustrated a preferred embodiment from an examination ice of which, in connection with the explanation, the invention should be fully understood and appreciated.

In the drawing:

Fig. 1 is a side elevational view of a plasma bottle constructed in accordance with the invention.

Fig. 2 is a sectional view taken through the same along its axis.

3 is a sectional view through the plug of the bottle on an enlarged scale.

Fig. 4 is a fragmentary sectional view through the bottle showing same during use.

Generally, the invention consists of a bottle of some flexible material, such as polyethylene, having two compartments, separated by a wall which is normally plugged during transportation of the bottle. The dried plasma is in one compartment, and sterile water in the other, if desired. The plasma compartment is unplugged when it is desired to use the same, and the plug becomes the cap for the bottle, such that when inverted the needle of the administering tube may be inserted through the plug into the bottle. After unplugging the plasma compartment and closing off the end of the bottle, the bottle is shaken to dissolve the plasma. When forced feeding is desired, the bottle is squeezed and its collapse increases the pressure of the flow of plasma.

Referring now to the drawing, the bottle is designated by the reference character 10, and it will be seen that same is formed in any conventional shape, such as for example, having a cylindrical configuration providing cylindrical side wall 12 with a bottom wall 14 closing off the bottle, and an upper neck 16 having an internally threaded mouth 18 adapted to be closed off by a cap 2t) with a male threaded portion 22. The bottle has a central diaphragm or wall 24 provided with a central reenforced threaded opening 26 coaxial with the mouth 18 and preferably of smaller diameter.

The wall 24 thus forms the interior of the bottle 10 into two compartments, the upper or water compartment 28 and the lower or plasma compartment 30. Obviously when used, as in Fig. 4, the compartments are inverted.

The cap 22 has a depending rod 32 of some inert material such as plastic, which telescopically engages with another rod 34 at the bottom of which is fastened a plug 36. If desired, a slot and pin connection may be provided to prevent separation of rods 32 and 34, but relatively tight frictional engagement is suflicient. The configuration of the telescoping members 32 and 34 is such that rotation of the cap 20 imparts rotation to the plug 36, irrespective of the positions of the cap and plug one relative the other. The plug 36 has an upper threaded part 38 which is of a size to engage with the threads of the mouth 18, and a lower threaded part 40 which is of a size to threadedly engage with the threads of the opening 26. The rod 34 is frictionally engaged in a suitable recess 42 in the plug 36 and the upper end of the rod 32 is fixed to the cap 20. There is a diaphragm 44 in the plug 36 to enable a needle 46 on the end of an administering tube 48 to be inserted therein as shown in Fig. 4 when the bottle 10 is used.

The bottle 10 is preferably formed of polyethylene or similar flexible resilient material, and while shown as an integral structure may be composite, that is-made up of two parts welded or cemented together to eliminate the need for complicated moulding procedures or coring. Any suitable means for supporting the bottle 10 inverted may be used, such as for example, a tape 50 secured to the side of the bottle by cement or the like provided with a grommet 52 or the like.

In filling the bottle, first the dried plasma. is disposed in the compartment 30. The assembled plug 36, cap 20 and the connecting rods 32 and 34, is then manipulated so that the plug 36 is screwed through the mouth 18,

Patented Apr. 2, 1957 greases after which the plug is lowered and part as is tightly screwed into the threaded opening as, thereby closing off the plasma in the lower compartment. Thereafter water may be introduced into the compartment 28 by any suitable means, and the cap 2% tightly screwed home. This process may readily be done under sterile conditions in the manufacturing laboratory, and if required, the completed package may be subjected to heat for sterilizing purposes. The upper compartment may be left empty if facilities to provide sterile water available at the place of use.

,In use, the bottle is prepared by first unscrewing the cap 20. While this is being done, the plug 36 is being removed from the opening 26. The plug is thereafter lifted and screwed into the mouth 18 from the bottom thereof, as shown in Fig. 4. The cap 12 and rods 32; and 34 are then pulled away from the plug 36. The bottle it) may then be shaken to dissolve all of the plasma. Thereafter it is inverted into position, the needle 45 inserted into the diaphragm 44 and the plasma immediately flows through the tube 48 to the patient. If pressure is desired, the attendant merely grasps the bottle 1d and squeezes the same and forces the liquid plasma through the tube 48. Any suitable valve arrangement may be used to admit air into the bottle as the liquid 54 is emptied.

Obviously where the bottle MD is made of an inflexible material, all of the advantages of the invention accrue with the exception of the advantage of being able to apply force by merely squeezing the bottle.

It is believed that the invention has sui'liciently been described to enable an understanding thereof, but it is desired to point out that considerable variation is possible without departing from the spirit and scope thereof as defined in the appended claims.

I claim:

1. A container for storing and administering plasma, which comprises a composite member having two compartments, an opening in one compartment for gaining access to the interior thereof from the exterior of the container and having a removable cap closing the container, a passageway between the compartments and a plug member normally blocking said passageway, means connecting the plug member and the cap whereby the removal of the cap will remove the plug from the passageway into the first compartment, the plug and opening having cooperative means whereby after the cap has been removed, it can be manipulated to cause engagement of the plug with the opening, the plug having a needle receiving diaphragm whereby to enable piercing of the diaphragm and communication with the interior of the container through the needle.

2. A container for storing and administering plasma, which comprises a composite member having two compartments, an opening in one compartment for gaining access to the interior thereof from the exterior of the container and having a removable cap closing the container, a passageway between the compartments and a plug member normally blocking said passageway, means connecting the plug member and the cap whereby the removal of the cap will remove the plug from the passageway into the first compartment, the plug and opening having cooperative means whereby after the cap has been removed, it can be manipulated to cause engagement of the plug with the opening, at least the second compartment being formed of flexible material whereby to enable the manual compression to decrease the volume of the container.

3. A container for storing and administering plasma, which comprises a composite member having two compartments, an opening in one compartment for gaining access to the interior thereof from the exterior of the container and having a removable cap closing the container, a passageway between the compartments and a plug member normally blocking said passageway, means connecting the plug member and the cap whereby the removal of the cap will remove the plug from the passageway into the first compartment, the plug and opening having cooperative means whereby after the cap has been removed, it can be ms ulatcd "to cause engagement of the plug with the ope-.nng, the and cap both being screw threaded, and the passageway and opening also being screw threaded, and the connecting means being a member having the plug and cap non-rotatively secured thereto.

4. A container for storing and administering plasma, which comprises a composite member having two compartmenis, an opening in one compartment for gaining access to the interior thereof from the exterior or" the container and having a removable cap closing the container, a passageway between the compartments and a plug member normally blocking said passageway, means connecting the plug member and the cap whereby the removal of the cap will remove the plug from the passageway into the first compartment, the plug and opening having cooperative means whereby after the cap has been removed, it can be manipulated to cause engagement of the plug with the opening, the plug and cap both being screw threaded, and the passageway and opening also being screw threaded, and the connecting means being a member having the plug and cap non-rotatively secured thereto, but axially movable relative one another.

5. A container as claimed in claim 3 in which the plug has two axially arranged parts, one part being screw threaded and having a smaller diameter than the screw thread of the opening but of a size to engage the screw thread of the passageway, and the second part being screw threaded and having a diameter to engage the screw thread of the opening.

6. A container for storing and administering blood plasma through a hollow administering needle, comprising a composite member having an inner and an outer compartment, the outer compartment adapted to contain water and having a cap thereon, a passageway between the compartments and a plug engaged in the passageway and closing same off, the first compartment adapted to have dried plasma therein, a means connected between the plug and cap and arranged to cause simultaneous rotation of plug and cap, and the plug being constructed to fit into the opening, so that the cap may be removed and will simultaneously remove the plug from the passageway, and said cap can further be moved to drive the plug into the opening to seal off the container but provide access between the compartments thereof.

7. A container as claimed in claim 6 in which the plug has a needle receiving diaphragm adapted to be pierced for draining liquid from the container through the needle.

8. A container as claimed in claim 6 in which there is screw-threaded engagement between the cap and opening, and between the plug and passageway, and when the cap is moved to drive the plug into the opening there is screw-threaded engagement between the plug and opening.

9. A container as claimed in claim 6 in which the means between the cap and plug is formed of at least two telescopically engaged members non-rotative one relative the other, but axially movable one relative the other.

References Cited in the file of this patent UNITED STATES PATENTS 1,275,315 Smith Aug. 13, 1918 1,413,703 Biehn Apr. 25, 1922 2,419,453 Kocevar Apr. 22, 1947 2,447,166 Daffer Aug. 17, 1948 2,693,189 Ryan NOV. 2, 1954

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US1275315 *Mar 14, 1918Aug 13, 1918Thomas O L SmithBottle.
US1413703 *Dec 7, 1918Apr 25, 1922Abbott LabClosure for hypodermic-solution containers
US2419453 *Jun 8, 1945Apr 22, 1947Anthony KocevarReducing coupling
US2447166 *Dec 9, 1946Aug 17, 1948William Daffer IrvenReversible stopper
US2693189 *Dec 15, 1950Nov 2, 1954Abbott LabVenoclysis equipment
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3070093 *Feb 25, 1959Dec 25, 1962George B CalkinsMedicament and diluent storing, mixing, and dispensing device
US3161310 *Oct 14, 1960Dec 15, 1964Baxter Don IncParenteral solution container
US4024952 *Oct 3, 1975May 24, 1977Koninklijke Emballage Industrie Van Leer B.V.Screw cap for a container
US4453636 *May 3, 1983Jun 12, 1984Meadows Bernard AStorage assembly
US4479578 *Apr 9, 1981Oct 30, 1984The West CompanySingle barrel two-compartment medicament container assembly
US4836370 *Feb 3, 1987Jun 6, 1989Steigmuhle Toss AgDual chamber container and method for forming an opening between the chambers of the container
US5088627 *Jul 25, 1990Feb 18, 1992Wheaton IndustriesMulti-chamber package for mixing and dispensing
US5226878 *Jan 10, 1992Jul 13, 1993Whitaker Designs, Inc.Two-container system for mixing medicament with diluent including safety wand to protect against improper titration
US5447226 *Jun 8, 1993Sep 5, 1995Societe De Conseils Et D'eutdes Des Emballages (S.C.E.E.)Dual compartment container with means for mixing and dispensing a product
US5634714 *Jun 28, 1995Jun 3, 1997Guild; WilliamFluid mixing and dispensing system for the rapid mixing of a prestored substance with a fluid and the dispensing thereof
US5893452 *Feb 13, 1997Apr 13, 1999L'orealMonopiece body for the separate packaging and mixing of at least two products
US6001643 *May 22, 1998Dec 14, 1999C-Med Inc.Disposable, automatable two chamber roller bottle providing a hydrostatic gradient between the two chambers for transplant tissue and simple, accurate cell propagation
US6022134 *Oct 24, 1997Feb 8, 2000Rxi Plastics, Inc.Mixing and dispensing container
US8147119 *Jul 24, 2002Apr 3, 2012Arnold Gregory KleinConvenience nectar mixing and storage devices
US8197116 *Feb 28, 2006Jun 12, 2012Klein Arnold GConvenience nectar mixing and storage devices
US20130068771 *Oct 11, 2011Mar 21, 2013David TongMulti-Dye Container
WO1984001355A1 *Sep 23, 1983Apr 12, 1984Von Scholten Bent Henrik NielsAn aerosol container or similar dispensing device for discharging pressurized liquids
Classifications
U.S. Classification206/221, 215/DIG.800, 604/416, 215/6
International ClassificationA61J1/00, A61J1/20
Cooperative ClassificationA61J1/2093, Y10S215/08, A61J2001/2031
European ClassificationA61J1/20D