US 2893918 A
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DEGEUR AN 7 T (IDIVIPOSHION Harold A..- Abramson, New York, NY.-
No Drawing. Application April 24, 19 57 Serial No. 654,634
1-s- Claims. or. 16'7-'-'-90) My present invention relates, generally, to innovations and" improvements in cosmetic deodorants of the'type in which an astringent salt such as aluminurn c'hloride alurnirium sulfate or aluminum chlorhydroxide is the basic active ingredient.
I Broadly stated, the invention is based on the unexpected discovery that silver protein or proteinates are compatible with the astringent salts commonly used as the basic ingredient's in cosmetic deodorants and when so used in combination therewith offer a number of important advantages. Several of these advantages arise from the fact that in my new antiperspirant and deodorant-compositions the concentrations of aluminum or other astringent-salts may be substantially lowered from the high -c oncentratiofis' in the order of 20% which are commonly used to as low as 2%.
The high concentrations of aluminum and other astringent salts presently employed arenot only damaging: to sensitive" tissues of the skin, produce allergies, and damage the orifices of the sweat glands,;but also maylead to destruction of the tissues and of clothing dueto'iormatiori' of excess acid. It is customary for many women to shave their armpits and the tiny lesions of the skin produced by shaving are potentially painful as well as potentially infective areas. A, I
An important object of'the invention is the provision of antiperspirants an'ddeo'do'rant's in which the concentration of aluminum and other astringent salts'is very sub-' tent of aluminum or other astriiig'eiit metal salt is substantially reduced so that the pain experienced on the use of deodorants is eliminated or substantially reduced, particularly immediately following shaving, andt'iss'ue damage and opportunity for infection are eliminated or sub-' stantially reduced. Y
Another object of theirivention is the provision of antiperspirant and deodorant compositions, containing astringent salts, which are bacteriostatic or exhibit bactericidal properties and therefore especially valuable when applied to the armpits immediately following shaving" thereof since the probability ofinfe'ction' of minute lesions of the skin isthereby markedly decreased.
Still another important object of the invention is the provision of bacteriostatic antiperspirant and deodorant compositions, containing astringent-salts; which are hypoa'ilergenic and suitable for use in' instances where eczema of the skin precludes the employment of ordinary antiperspirants and deodorants containing high concentrations of astringent salts.
Another object of the invention is the provision of bacter'i'ostatic antiperspirant and deodorant compositions in which the content ofastringent-saltsi's so reduced' that damage to clothing coming in contact with the compositionsin solution, jelly or ointment-form is ehniinated or 2,893,918 Patented July 7, 1959 2. substantially decreased and laundering-of the clothing: or garments is simplified.
Another object of the invention is the provision of antiperspirant and deodorant compositions containing astringent salts and silver protein or proteinate in synergistic proportions.
Another object of the invention is the provision of a deodorant and antiperspirant dusting powder containing an astringent salt and silver protein.
Certain other objects of the invention will, in part, be obvious and will, in part, appear hereinafter.
The various objects of the invention are accomplished or obtained by incorporating small amounts 'ofsilver protein in the antiperspirant and deodorant compositions having greatly reduced concentrations of astringent salts.
For a more complete understanding of the nature and scope of my invention, reference may now be had to the following detailed description thereof wherein a number of illustrative examples are set forth.
The astringent salts which may be used in the antiperspirant and deodorant compositions of the present invention include: aluminum sulfate, aluminum chloride, aluminum chlorhydroxide complex, magnesium acetate, zinc acetate, sodium zirconium lactate. These salts ma'y be used alone or in admixture. Also, any one of the metals may be combined with any one of the acid radicals in the group. In deodorant dusting powders powdered astringent salts such as aluminum silicate (talc) or magnesium trisilicate may be used.
Silver protein is available in several known forms which are useful in this invention, including: strong protein silver (silver protein, strong N.F.Argyrol"), mild protein silver (silver protein, mild N.F.), Barnes colloidal silver iodide 20% containing 1% zinc in colloidal form, Barnes silver protein zinc compound, and colloidal silver and silver oxide with a derived egg albumen (Collargol). Most of these forms of silver protein are described in The Merck lndex- -fith edition. As in the case of the astringent salts, the silver proteins or proteinates may be used either alone or in combination.
Polyhydroxy alcohols, alone or containing as much as up to 1.2 times their weight of water serve as the carriers or vehicles for the antiperspirant and deodorant compositions. The polyhydroxy alcohols of choice are glycerine and propylene glycol. p g
The formulations of this invention may be in the form of solutions, ointments, sticks, vanishingcrea'm and soap.
If desired, up to 5 by weightof urea may be used in the formulations. Perfumes of known type may be incorporated to make theformulations more elegant. Likewise, coloring agents may be used if desired. Neosilvol (silver iodide rendered colloidal with a soluble gelatin base) is itself a beautiful opalescent golden color andfor that reason is preferred rather thanthe darker silver protein preparations where color is a factor and other coloring agents are not included.
Example 1 Example 4 Neosilvol gm Propylene glycol cc -Alurninum chlorhyd'roxide gm Water cc --Grain alcohol e l A v Example 5 Neosilvol I g'm Propylene glycol cc Aluminum sulfate gm Water (-0 Example 6 Neosilvol gm Propylene glycol cc Aluminum chloride gm Example 7 Neosilvol gm Propylene glycol cc Aluminum chlorhydroxide gm -Water cc Example 8 Neosilvol gm Glycerine cc-.. Aluminum sulfate gm Example 9 Silver protein, strong N.F gm Propylene glycol l cc Aluminum chloride gm Water V ec 0 Example 10 Silver protein, strong N.F grn Propylene glycol cc Aluminum chlorhydroxide grn Example 11 Silver protein, strong N.F gm Glycerine cc Aluminum sulfate gm Water cc 7 Example 12 Silver protein, strong N.F gm Propylene glycol cc Aluminum chloride gm Water cc Example 13 Silver protein, strong N.F gm Glycerine cc Aluminum chlorhydroxide grn" Water cc Grain alcohol r'c' Example 14 Silver protein, strong N.F gm Glycerine cc Aluminum sulfate gm Example 15 Silver protein, mild N.F gm Propylene glycol cc Aluminum chloride gm Glycerine rr- Example 16 Silver protein, mild N.F gm
Glycerine or Aluminum chlorhydroxide g m Example 17 Silver protein, mild N.F gm 0.2 Propylene glycol cc 88 Aluminum sulfate m 2.0 Glycerine 10 Example 18 Silver protein, mild N.F gm .02 Propylene glycol cc 88 Aluminum chloride gm 2.0 Water or 10 Example 19 Silver protein, mild N.F gm .02 Glycerine re 98 Aluminum chlorhydroxide gm 2.0
7 Example 20 Silver protein, mild N.F gm .02 Propylene glycol re 98 Aluminum sulfate gm 20 Example 21 Neosilvol I m 0.2 Glycerine cc 88 Aluminum sulfate m 2.0 Propylene glycol cc 10 Example 22 Silver protein, strong N.F gm .02 Glycerine (c 83 Aluminum chloride gm 2.0 Propylene glycol re 10 Example 23 Silver protein, strong N.F gm 0.2 Glycerine 50 Aluminum chlorhydroxide gm 2.0 'Propylene'glycol 48 Example 24 Silver protein, mild N.F gm 0.2 Glycerine cc 50 Aluminum sulfate m 2.0 Propylene glycol Pl 43 Example 25 Silver protein, mild N.F gm .02 Glycerine 10 Aluminum chloride gm 2.0 Propylene glycol cc 88 Example 26 Silver protein, mild N.F gm.... 0.2 Glycerine 10 Aluminum chlorhydroxide gm 2.0 Propylene glycol cc 88 Example 27 Neosilvol gm .05 Propylene glycol cc 40 Aluminumsulfate gm 10 Water cc 50 A Example 28 Silver. protein, strong N.F. gm .05 Propylene glycol 50 Aluminum chloride "gm-.. 10 Water cc 40 v V 4 7 Example 29 Silver protein, mild N.F. gm .05 Propylene glycol cc 50 Aluminum chlorhydroxide gm 10 yce i e N 4 Example 30 Neosilvol A I gm 0.5 Glycerine re 50 Aluminum sulfate gm Propylene glycol cc.... 40
Example 31 Silver protein, strong NF. gm- 0.5 Glycerine cc 80 Aluminum chloride gm 10 Water cc 10 Example 32 Silver protein, mild N.F. grn 0.5 Propylene glycol p cc .88 Aluminum chlorhydroxide gm 2.0 Water no 10 Example 33 Neosilvol gm 0.2 Propylene glycol ..cc 88 Magnesium acetate g 2.0 Water re 10 Example 34 Silver protein, strong NF. gm .02 Glycerine cc 98 Zinc acetate g 2.0
0 Example 35 I Silver protein, mild NJF. gm....- 0.1 Glycerine cc 50 Sodium zirconium lactate "gm-.. 1.0 Propylene glycoli cc 49 Example 36 Neosilvolcm 0.5 Glycerine cc..- 98 Magnesiumacetate g 0.5 Zinc acetate gm 0.5 Sodium zirconium lactate gm.. 0.5
Example 37 Neosilvol cm 0.1 Aluminum chlorhydroxide gm- 2.0 Alcohol (grain) cc 22 Glycerine cc 8 Water no 70 Example 38 Neosil'vol gma.-. 0.1 Aluminum chlorhydroxide ..gm 2.0 Ureagm..- 5.0 Alcohol (grain) 22 Glycerine cc 8 Water 70 The formulationsv of. Examples 1-3.8 are all solutions in which the vehicle contains a pol'yhyd'roxy al'coholalone or with. water and/or alcohol: Such solutions, or just the active ingredients, can be put into the form ofcreams of desired consistency by addition, or substitution, of such cream-forming substance as glyceryl monostearate, as follows:
0 The following examples illustrate other physical form or embodiments of the invention:
Example 40.-Deodorant stick Neosilvol gm 0.2 Aluminum sulfate g 1.0 Sodium stearate gm 7.5 Propylene glycol ce 5.0 Alcohol (grain) cc 87.5
Example 41.--Deod0rant stick soap Silver proteinate, mild gm.... 0.5 Aluminum sulfate gm 1.0 Glycerine cc 8 Soap -gm-..
1 Solid laundry soap or transparent glycerlne soap.
Example 42.-Powder Neosilvol -grn 0.2 Aluminum sulfate gm 0.5 Zinc stearate gm 5.0 Colloidal kaolin gm 15 Talc "gm. 80
Example 43.-P0wder Argyrol g1'n 0.2 Aluminum chloride gm 1.0 Zinc stearate gm; 5.0 Talc gm 94.0
Example 44.-'-Powder Neosilvol -l -gm 0.2 Zinc acetate r ...s-.' .gm 1.0 Talc gm Zinc stearate gm 1.0
Example 45.--Po'wde'r Neosilvol gm; 0.2 Magnesium acetate grn 2.0 Talc grn 98.0 Zinc stearate gn'1 1.0
From the foregoing examples it will be seen that as little as 1% by weight up to as much as about 10% by weight of the astringent salt or salts may be used with as little as 0.02% up to as much as 0.5% by Weight of silver protein. Preferably, the astringent salt and the silver protein are employed in compatible proportions so that a precipitate of the silver does not form. However, such precipitates do not make the compositions ineffective.
The foregoing preparations or formulations show commercially suitable deodorant, antiperspirant and bacteriostatic activity. The formulations are stable. Thus, in the lower concentrations such as would ordinarily be used, the solutions are stable at 45 C. for one month. The formulations are also light stable, being able to withstand exposure for at least one month to a watt spotlight at a distance'of one foot. The excellent stability of the formulations-was unexpected in view of the known tendencyof silver protein or proteinates to be very unstable in aqueous solution, the known tendency of astringent salts to precipitate proteins, and the known light sensitivity of the silver proteinates. It is believed that the excellent stability is due to a complexifig phenomenon to which reference will be made below.
The remarkable deodorant effects of as little as 0.02% silver protein in the presence of aslittle as 2.0% astringent salt suggests that a synergistic activity of astringent salts and silver protein or proteinates causes them efiectively toreinforce one another so as to exercise their deodorant and antiperspirant activity both on the orifices of the sweat glands and on bacteria growth. The dilute silver proteinate solutions are stable in the presence of relative high concentrations of astringent salts as the foregoing examples bringout, butas the silver proteinate concentration increases the stability decreases. It is important to note that the least stable of the common astringent salts in the presence of silver proteinates are the sulfates, although the mixture containing the precipitate still retains deodorant activity. In addition to use as antiperspirants and deodorants, the foregoing formulations may also be used in the treatment of the unpleasant odor of athletes foot. The synergistic activity of the astringent salts and the silver protein or proteinates reduces the odor after one application if allowed to remain in contact with the lesions during the day. In many instances the bacteriostatic action reduces the inflammatory processes so that the secondary infection is eliminated. Thus, preparations similar to Examples 1-36 above have been used successfully in eliminating the symptoms and signs of athletes foot when applied daily for several days.
Glycerine is especially desirable in the formulations used for treatment of athletes foot since it is an excellent peptizing agent and if allowed to remain between the toes throughout the day aids in dissolving dead tissues. The peptizing action may be enhanced by addition of 5% urea of the formulations.
The following theoretical basis for the synergistic action may be hypothesized. It is well known that astringent salts are medically valuable for their action on the skin. They, therefore, combine with the skin constituents. By the same token, astringent salts react with proteins, and therefore, form complexes with various types of silver protein or proteinate's. Thus, in the foregoing formulations the astringent salts commonly used as deodorants V and as astringents for the skin probably act as binders for silver proteinate on the skin. In this way the astringent salts act to maintain a film of silver on the skin derived from the low concentrations of applied silver proteinate solutions which act synergistically to decrease the development of odor-producing bacteria on the skin.
In any event, the combinations of astringent salts and the silver proteins or proteinates exhibit antiperspirant and deodorant properties far in excess. of what these constituents exhibit separately.
It will be understood that the foregoing examples are intended to be interpreted as illustrative and not in a limiting sense.
What is claimed as new is:
1. A deodorant composition comprising about 1 to percent by Weight of an astringent salt wherein the metal ion is selected from at least one of the group consisting of aluminum, zirconium, magnesium and zinc, a substantially smaller compatible amount of silver protein, and an inert carrier vehicle for said astringent salt and silver protein.
2. A deodorant composition containing from about 1 to 10 percent by weight of an astringent salt wherein the metal ion is selected from at least one of the group consisting of aluminum, zirconium, magnesium and zinc, from about 0.02 to 0.5 percent by weight of a silver protein, and a polyhydroxy alcohol carrier containing up to as much as about 1.2 times its own weight of water.
3. A deodorant composition comprising about 1 to 10 percent by weight of an astringent salt wherein the metal ion is selected from at least one of the group consisting of aluminum, zirconium, magnesium and zinc, and the 'anion is selected from the group consisting of chloride,
chlorhydroxide complex, acetate, lactate and sulfate, a substantially smaller compatible amount of silver protein, and an inert carrier vehicle for said astringent salt and a silver protein.
4. A deodorant composition containing from about 1 to 10 percent by weight of an astringent salt wherein the metal ion is selected from at least one of the group consisting of aluminum, zirconium, magnesium and zinc, and the anion is selected from the group consisting of chloride, chlorhydroxide complex, acetate, lactate and sulfate,
from about 0.02 to 0.5 percent by weight of a silver pro- Soap- Silver iodide rendered colloidal with a soluble gelatin Silver iodide rendered colloidal a-soluble gelatein, and a polyhydroxy alcohol-carrier selected from at least one of the group consisting of glycerine and propylene glycol containing up to as much as about 1.2 times its own weight of water. v j
5. A deodorant composition comprising about 1 to 10 percent by weight of an aluminum salt, asubstantially smaller compatible amount of silver protein, and an inert carrier vehicle.
-6. A deodorant compositioncomprising from about-1 to 10 percent by weight of an aluminum salt having a negative radical selected fromthe group consisting of chloride, chlorhydroxide complex, acetate, lactate and sulfate, from about 0.02 to 0.5 percent by weight of silver protein, and a polyhydroxy alcohol carrier selected from at least one of the group consisting of glycerine and propylene glycol containing up to as much asabout l.2
times its own weight of'water'. 7
7. A de'odor'ant' composition having substantially the following formulations .Silver iodide rendered colloidal with a soluble gelatin A 8. A deodorant composition having substantially the following formulation:
Silver protein, mild N.F. gm 0.1
Propylene glycol, m 49 9 A deodorant composition having substantially the following formulation:
'Silver iodide rendered colloidal with a soluble gelatin 10. A deodorant composition having substantially the following formulation:
base m 0.2 Aluminum sulfate g 1.0 Glyceryl monostearate ..cc 14 Glycerine, cc 5 Mineral oil 2 Water or 79 tin base g 0.2
. Aluminum sulfate gm 1.0 Sodium. stearate gm -7.5
Propylene glycol 5.0 Alcohol (grain) cc 8,7,5
Silver proteinate, mild gm i0.5
Aluminum sulfate gm .1.0 'Glycerine .8
13. A deodorant composition having substantially the FOREIGN I 'ATENTS following formulation:
87,631 Austria Mar. 10, 1922 Sflggeiodide rendered colloidal with a soluble gzlrztin 0 2 OTHER REFERENCES Al i lg ulf t g :5 5 Remington: Practice of Pharmacy, Mack Pub. 00.,
Zinc tea ate 5 0 Eastol'l, P3, pp.
colloidal kaolin 15 Silvol, Parke, Davis and Co. (16 p. pamphlet), (ca.
Talc gm 80 1916} Harry: Modern Cosmetlcology, 4th ed., Leonard H111 References Cited in the file of this patent 10 Books London, 1955, Chapter UNITED STATES PATENTS 2,732,327 Teller Jan. 24, 1956