|Publication number||US3057349 A|
|Publication date||Oct 9, 1962|
|Filing date||Dec 14, 1959|
|Priority date||Dec 14, 1959|
|Also published as||DE1213958B|
|Publication number||US 3057349 A, US 3057349A, US-A-3057349, US3057349 A, US3057349A|
|Original Assignee||Aaron Ismach|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (3), Referenced by (95), Classifications (7)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Oct. 9, 1962 A. ISMACH MULTI-DOSE JET INJECTION DEVICE Filed Deo. 14, 1959 5 Sheets-Sheet 1 ATTORNEYS.
Oct. 9, 1962 A. lsMAcH 3,057,349
MULTI-DOSE JET INJECTION DEVICE Filed Dec. 14, 1959 5 Sheets-Sheet 2 IN VEN TOR. AA RoN /sMAcH BY //W. @7W QM a@ /9 TTORNEYS.
Oct. 9, 1962 A. lsMAcH 3,057,349
MULTI-DOSE JET INJECTION DEVICE Filed Dec. 14, 1959 3 Shee'cs-Sheet 3 IN V EN TOR.
74 AARON /sMAcH BY V @a ff/)dw ATTURNEYS.
United States Patent O 3,057,349 MULTI-DOSE JET INJECTION DEVICE Aaron Isrnach, 3025 W. 32nd St., Brooklyn 24, N.Y. Filed Dec. 14, 1959, Ser. No. 859,510 12 Claims. (Cl. 12S-173) The present invention relates to medical inoculant injection instruments and more particularly to high speed multidose hypodermic jet injection instruments.
The present invention provides a novel combination of means for effecting a sterile inoculation of vaccine or other medicament by providing a fine jet of inoculating uid which is impelled at high speed and with great pressure under the skin of the subject to whom the inoculant is administered. The invention makes possible the delivery of an exactly metered dose of a desired vaccine beneath the skin of a patient without the use of a needle and in a relatively painless manner without breaking the surface of the skin.
The instant invention provides improvements over prior methods of effecting inoculation by means of a thin high pressure stream or jet of vaccinating fluid, wherein multiple doses of vaccine -are given -to a number of patients without the need for reloading the injection instrument with a new reservoir of vaccine before each shot is administered. The present invention is particularly novel and useful in providing a jet injection instrument capable of administering inoculation shots to a very large number of patients within la very small interval of time, without any necessity for sterilization of the instrument between shots, without risk of injury or crossinfection to the patient, and with great accuracy in metering the required dosage of inoculating fluid. In use, rates as high as 4,000 patients per hour have been yachieved in administering a 1/2 cc. dose of Vaccine.
It is an object of the instant invention to provide a jet hypodermic injection device by which inoculations can be given to more patients in a shorter time, with much greater safety and much more economically than was formerly possible either with the conventional hypodermic needles and syringes or with other types of hypodermic injection devices.
It is another object of the instant invention to provide a hypodermic jet injection device which possesses an extremely high shooting rate, which permits the vaccine being administered to be changed from one type to another very easily, rapidly, and under sterile conditions, and which permits prescribed dosages of vaccine to be altered very rapidly and accurately.
Another object of the present invention is to provide a hypodermic jet injection gun which is well balanced with a centrally disposed load, which can be operated and comfortably held by the operator in one hand, leaving the operators other hand free to swab or grasp the patient, which is relatively noiseless and free from recoil, and which lends itself to long periods of fatiguefree operation. The latter characteristic of this invention is extremely important when inoculations are being administered by a high speed jet injection, since if the gun is permitted to slip on the arm of a patient when it is fired, a nasty cut may result.
Another object of the present invention is to provide a hypodermic jet injection device which can be quickly and easily disassembled, which can be easily and eiliciently sterilized by autoclaving or other means, and which can be readily serviced by using conventional hand tools without the need for specially adapted tools or devices.
Another object of the present invention is to provide a hydraulic jet injection gun so constructed that a failure in any one portion of the gun will be isolated to that portion and so constructed that there is a path to the 3,057,349 Patented Oct. 9, 1962 ICC exterior of the gun near each seal in the mechanism. The latter feature insures that if any one of the seals should fail, iiuid (either inoculating fluid or hydraulic fluid) will appear at the surface of the gun adjacent to the seal and enable the operator to immediately discern which of the several seals has failed or is leaking.
Another object of the present invention is to provide a hypodermic jet injection device which is ideal for use in isolated areas where it is difcult to obtain spare or replacement parts, since the device uses standard components, and is relatively trouble-free, and is easy to keep in operating condition.
With the device of the instant invention only the inoculating fluid goes below the skin level of the patient, and it is relatively easy to insure sterile operating conditions; whereas with conventional hpyodermic injection devices part of the device itself penetrates beneath the skin and necessitates the most stringent requirements for sterility in the older devices.
The present invention provides a hypodermic jet i11- jection device, which requires no sterilization either between shots or even when the type of vaccine is changed, which delivers accurately measured doses of vaccine once it is vpre-set, which is not dependent upon the operator `to control accuracy of the dose as conventional devices are, and which creates no danger of cross-infection, since nothing but the inoculating uid itself penetrates beneath the skin of the patient. The latter characteristic is especially helpful in preventing the spread of infectious hepatitis, and the danger of spreading hepatitis infection is an outstanding disadvantage of the older method of administering inoculations by the use of syringes and hypodermic needles. It is possible for a patient to be a carrier of hepatitis and capable of seriously infecting another patient with the disease, although the carrier himself may show none of the symptoms associated with hepatitis. One of the outstanding benets conferred by the invention in helping to prevent hepatitis or other cross-infection, is that if operation of the jet injection device is commenced with the device in a sterile condition, the gun will maintain its own st erility..
AIt is another object of the present invention to provide a hypodermic jet injection gun comprising tWo separate but interrelated pump mechanisms: a vaccine pump and a hydraulic pump. Both pumps are self-priming and exceptionally smooth Working in operation.
It is a further object of the instant invention to provide a hypodermic jet injection gun which is of an inestimable value for use under emergency or epidemic conditions when it is essential that a great many shots be administered in the shortest possible time with a maximum amount of safety. The efliciency of design and simplicity of operation of the invention obviate the need for a skillful operator. Almost any intelligent person can satisfactorily operate the gun after a rudimentary amount of training.
Unlike most earlier hypodermic jet injection guns, the instant invention is free from danger of sucking fluid back from a patient either during or after the firing cycle is completed so that the danger of cross-infection is almost completely avoided; this is obviously an important advantage at all times, but is particularly apparent when the gun is used under emergency conditions. The characteristic ofthe gun which permits it to be preset to deliver an exceptionally accurate dose of vaccine and repeatedly deliver this same dose each time it is red is of great value when the gun is used under any circumstances, but is particularly important when the gun is to be used under emergency, disaster or epidemic conditions by a relatively untrained operator.
Broadly described, the present invention comprises a hypodermic jet injection device including vaccine pump means capable of meteringan exact amount of inoculating iiuid into a vaccine pump chamber, outlet valve means providing a small outlet oriiice for vaccine from the vaccine pump means, a piston forming part of the vaccine pump means, combined hydraulic pump and spring means for driving the vaccine pump piston very rapidly but smoothly into the vaccine pump chamber to expelV a metered amount of vaccine through the outlet valve oriiice in a thin stream under tremendous force andpressure, and valve means for storing and selectively releasing the force of the hydraulic pump and spring means to drive the vaccine pump piston.
Additional objects and advantages of the invention will be settorthin part in the 'description which `follows and in part will be obvious from the description, or may |be learned by practice ofthe invention, the objects and advantages being realized `and -attained bymeans of the instrumentalities and combinations particularly pointed out in the appended claims.
The invention consists in the novel parts, constructions, arrangements, combinations, and improvements shown and described.
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate one embodiment of the invention and together with the description, serve to explain the principles of the invention.
Of the drawings:
FIG. l is a central vertical section of the device;
FIG. 2 is a fragmentary enlarged section ofthe nozzle portion of FIG. 1;
FIG. 3 is a fragmentary enlarged section of the actuatingvalves and hydraulic piston portions of the device;
Y FIG. 4y is a section taken on the line 4 4 of FIG. 1;
. FIG.- 5 isacross-section of the vaccine extracting tube; FIG. I6` is a side elevation of the device in use and showingthesight port;
. FIG. 7 -is a plan section taken on theline 7-7 of FIG., 6;
FIG. 8 is a fragmentary section of the comparable portion kor" FIG. l, but showing the device cocked` and ready to eject vaccine.rk
It is to be understood that both the foregoing general description and the following detailed description are exemplary andexplanatory, but Iare not restrictive of the invention.
In accordance with the invention, a hypodermic jet injection device is provided having meansto meter a prescribed. dose of vaccine, means to accumulate and apply force to eject vaccine under pressure, and means to control thefaccumulation and release of the force. In the present preferred embodiment the means to meter the dose of vaccinecomprises, a vaccine pump having an intake valve and an outlet valve, the means to Iaccumulate and apply force comprises a hydraulic cylinder and spring, `and the means-to control the accumulation and release of force comprises a series of hydraulic valves.
' Reference will now be made in detail -to the present preferred embodiment of the invention, an example of which is illustrated in the accompanying drawings, and in which Ilthe `means for accumulating and'applying force and pressure on the metered amount of vaccine comprises (FIG. 1) a hydraulic chamber 10, a hydraulic piston 12, a spring` chamber 14, Ia compression spring 16, and spring guide18.` Thedevice includes a main body 19 which in turn comprises a barrel 20` and grip 21 and the hydraulic chamber and the spring chamber 14 are formed in the barrel 20. The spring chamber 14-of the barrel 20 is closed with a square cap 22 to which a dosage adjusting screw24wis threadedly engaged. At its interior end the dosage adjusting screw 24 is provided with a thrust ball l`bearing 26 which bears against one end of the spring 16. The dosage adjusting screw 24'has an adjusting knob 28 secured to its exterior end to per-mit hand operation of the screw. At one end the spring 16 bears against the thrust ball bearing 26 and at the other end bears against the hydraulic piston' 12^so that -thei spring-may be adjustably compressed between these two bearing surfaces (thrust bearing 26 and hydraulic piston 12) by -turning the dosage adjusting screw 24.
As embodied, the hydraulic piston 12 includes a plunger 30 which reciprocates in a cylinder 31 formed in the forward end of the barrel 20. Also Ias embodied, the means to meter vaccine comprises a vaccine pump cylinder 33 formed by a barrel extension 32 which is attached to the barrel 20 by `a threaded'barrel extension cap 34. A vaccine pump piston 36 is secured to the hydraulic piston plunger 39 at the forward end of the plunger and the vaccine piston k36l reciprocates in-the vaccine pump cylinder 33 responsive to movement of the hydraulic piston 12. Included in the vaccine pump piston 36 is a sealing ring groove 38 in which appropriate sealing rings may be mounted to seal the forward portion, or lvaccine chamber 39, of the vaccine pump cylinder 33 from the rear of the cylinder.
The forward portion of the barrel extension 32 is adapted to receive a closure member 40, and the closure member` 40 is held rmly in place at the end of the barrel extension 32 by a nozzle cap 42 which is threadedly engaged to the exterior lof the barrel extension 32. The closure member 40 is provided with `a ball check outlet valve 44 and carries appropriate sealing rings. At its forward extremity the nozzle cap 42 carries a sapphire orifice insert 46 which is bored to a veryclose tolerance and which determines the diameter of the jet stream of inoculating iluid.
A vaccine inlet valve 48 is carried by `a member 50 which is secured to the top of the barrel extension 32, and a vaccine inlet tube 52 leads from the vaccine inlet valve 48 to the vaccine chamber 39 in the barrel extension 32. A vaccine extracting 4tube 54 is wedged on the tapered nose of the vaccine inlet valve 48 and secured thereto by conventional means. The tube 54 includes a right angle bend so that .its rear portion extends in a vertical direction when the device or gun is in firing position.
Within the upright portion of the vaccine extracting tube S4 is .an air vent tube 55 of smaller diameter but concentric with the vaccine extracting tube S4. The vaccine eX- tracting tube 54 includes -a longitudinal port 56 by means of which vaccine is withdrawn from a conventional vaccine bottle 58 and into the tube 54.
The air vent tube 55 is provided with an air lter 60 which in use would be filled with sterile cotton to trap any impurities which might otherwise lbe drawn into the vaccine bottle 58 along with outside air as vaccine is Withdrawn from the bottle.
A clip 62 (FIGS. 4 and 7) is secured to the barrel 20. On top and centrally disposed on the clip 62 is a U-shaped tube support 64 which is Welded or otherwise secured to the clip 62. The Vaccine extracting tube 54 is held by the U-shaped tube support 64 and the support 64 is provided with two small stops 66 which come to rest against the upright portion of the tube 54 and determine the position of the clip 62 on the barrel of the gun stock 20. The U- shaped tube support 64 also acts as a positive stop for the vaccine bottle 58 when the bottle is pushed onto the up- `right portion of the tube 54 to provide the vaccine supply for operation ofthe gun.
The U-shaped tube support 64 secures the vaccine extractingtube 54 lagainst horizontal movement and a spring loaded retractable vaccine extracting lock 68 secures the needle tube 54 against vertical movement. The lock 68 yand the tube support 64 thus cooperate to hold the tube S4 in 4a rigid, upright, and easily accessible position and at the same time prevent the relatively delicate vaccine extracting tube 54 from being easily dislodged and Abent or otherwise damaged. The tube support 64 also acts as a channel to secure the air `vent tube 5S against horizontal movement and the stops 66 in the support 64 help to secure the air vent tube from vertical movement. In use, t-he air vent tube 55 acts to admit air to the vaccine bottle S8 as vaccine is Withdrawn and prevents the rformation of a.
vacuum within the bottle.
jaw being attached to each side of the clip, and secured to each bottle jaw 70 is a bottle gripper 72. The bottle jaws and grippers are lof a spring type to accommodate automatically any standard size vaccine bottle and lock it in -a secure upright position on the center of the gun. By having the bottle of vaccine centrally disposed over the grip or handle portion of the gun, the weight of the bottle is carried at the horizontal center of gravity of the gun and directly above the hand of the operator. This characteristic tends to preserve ldynamic balance and reduce operator fatigue.
As embodied, the means to control the accumulation and release of force comprises the cocking mechanism, the tiring mechanism, and the conduits and valves which control the application of hydraulic power to the gun; these elements are contained in the grip 21 (FIGS. l and 3). The gun is provided with a cocking trigger 74 and a tiring trigger 76. rIhe conduits and valves contained in the grip portion of the gun control the flow of hydraulic fluid depending on the condition of the valves. In FIG. 3, the valves are shown in the static condition. 'Ilhe lowest valve is an unloading valve 78 and is lightly spring loaded. When the gun is not being cocked hydraulic fluid from a hydraulic pump (not shown) takes the path shown in FIG. 3, since very llittle pressure is required to overcome the light spring resistance of the unloading valve 78.
When the cocking trigger 74 is depressed, it moves a cocking pin 80 toward the rear of the gun and closes the unloading valve 78. With the unloading valve 78 closed by the joint action of the cocking trigger and cocking pin, the hydraulic fluid overcomes the resistance of a check valve 82 and enters the hydraulic chamber 10 where it acts on the forward face of the pis-ton 12 and causes the piston 12 to be moved to the rear of the gun fully compressing the spring 16.
The hydraulic pump mechanism (not shown) is provided with a pressure relief valve which acts to prevent further displacement of the piston when a certain predetermined pressure is reached in the hydraulic system. In the present embodiment the hydraulic pump (not shown) is provided with a pressure actuated switch which causes an electrical counter to advance one digit just prior to the time when the pump pressure relief valve opens. The electrical counter makes a distinctly audible click at this stage of the cycle permitting the operator to know that the gun is in the fully cocked position and obviating the need for his visual observation of any other signal that the gun is cocked and ready to re. This use of an audible signal to indicate that the gun is in a tiring condition has been helpful in permitting an operator to achieve a high shooting rate.
The trigger 76 when depressed actuates a trigger pin 84 which in turn opens a spring loaded ball check valve 86 permitting rapid escape of the hydraulic lluid from the hydraulic chamber l0. The release of the hydraulic fluid from the chamber l()` permits the spring 16 acting through intermediate parts to drive the piston 36 of the vaccine pump forward into the vaccine chamber 39 with great speed and force.
The valves and conduits necessary for proper functioning of the hydraulic system are appropriately mounted in the grip portion of the gun by conventional means and with sealing rings as required and as shown in -FIGS. l and 3. The exterior ends of the inlet conduit 87 and outlet conduit 89 are provided with conventional connectors for hydraulic hose (not shown).
Both sides of the forward end of the barrel 20 are provided with a sight port 88 (FIGS. 4 and 6) through which the forward end of the plunger 30 may be viewed in the present embodiment. The sigh-t port 88 is graduated from 0.`l cc. to 1.0 cc. in tenths of cubic centimeters.
In operation, a conventional vaccine bottle is pressed onto the combined vaccine extracting tube 54 and air vent tube 55 and rrnly secured by the bottle jaws 70 and fingers 72. The U-shaped tube support 64 acts as a positive stop to insure that the needle is inserted to the correct vertical depth in the bottle.
When the operator depresses the cocking trigger 74 the cocking pin closes the unloading valve 78 causing pressurized hydraulic uid to enter the chamber 16 and push the piston 12 to the rear against the force of the spring 16. When the spring 16 is fully compressed, the pressure relief valve on the hydraulic pump (not shown) opens to prevent further llow of fluid into the chamber 10. As previously described, a pressure actuated switch causes the electrical counter means (not shown) to advance one digit with an audible click. When the operator hears the click, he knows that the gun is fully cocked and releases pressure frorn the cocking trigger 74. The hydraulic fluid is trapped in the chamber 10 by the ball check valve 82 and continues to hold the spring 16 in a compressed condition.
An important and distinctive feature of the instant invention is its cocking system. During each ring cycle, the unloading valve 78 remains open except when the cocking trigger 7-4 is depressed. The hydraulic system is thus under load only for a brief period in each cycle when the hydraulic piston 12 is displaced against the energy of the spring `16 by hydraulic fluid pressure. When the unloading valve is in its normal position, the hydraulic system is unloaded, hence the nomenclature unloading valve. Since the Ihydraulic system is under load only when the gun is actually being cocked, regardless of how long the operator waits between shots, the wear and strain on the parts of the hydraulic system during each cycle are almost negligible. This important characteristic, in practice, has permitted the gun to be tired hundreds of thousands of times Without the need for overhaul or maintenance.
When the piston 12 is pushed to the rear of the gun by hydraulic fluid during the cocking operation, it acts through intermediate parts -to move the vaccine pump piston 36 toward the rear an equal distance. The movement of the Vaccine piston 36 to the rear tends to create a vacuum within the vaccine chamber 39 'and causes Vaccine to be drawn into the chamber 39 in an amount pre-determined by the distance through which the vaccine piston 12 is set to move. The vaccine is withdrawn from the bottle 58 through the port 56 into and through the vaccine extracting tube 54 past the vaccine inlet valve 4S and through the vaccine inlet tube 52 into the vaccine chamber 39. The ball check valve 44 serves to prevent the entry of any air or suckback of any fluid during the loading cycle of the vaccine pump, but the spring pressure on this valve 44 is light enough to be easily overcome during the firing or ejection cycle of the vaccine pump.
Side port 56 is employed in the vaccine extracting tube 54 to prevent rubber from the vaccine stopper from entering the needle tube when the stopper is pierced. The side port 56 also provides a change in direction in the vaccine ow path which aids in preventing foreign particles from being entrained with the vaccine entering the pump and clogging the outlet valve 44, the inlet Valve 48, or the jet nozzle orilice 46. The concentric air vent tube 5-5 yields a stronger structure for lthe needle assembly and minimizes the size of the hole which must 'be made in the vaccine stopper thereby effecting la. better seal between stopper and tube and minimizing the tearing off of particles of rubber. This characteristic is important in helping to insure trouble-free operation, since it is not uncommon for pieces of rubber stopper to be broken olf when the needle end of the tube assembly is inserted into the vaccine bottle.
With the gun cocked, when the operator depresses the trigger 76, it acts through the ring pin 84 to open the check valve 86, and the hydraulic iluid locked in the chamber 10 is given a free path back to the hydraulic reservoir. The release of hydraulic uid pressure from the piston 12 permits the spring 16, acting through intermediate parts, to drivev the vaccine pump piston 36 forward with tremendous force and speed. The forward movement of the vaccine pump piston 36 causes the vaccine or inoculating fluid in the chamber 39' to pass through the check valve 44 and lbe ejected from the front of the gun through the jeweled orifice 46 in a small diameter jet.
The conduits and passageway in the gun are constructed so as to offer a sufcient resistance to provide hydraulic damping to the forward movement of the piston 12. This damping is in addition to the damping normally attained due to the resistance encountered by the vaccine as it is forced lthrough the jet orifice. This additional damping permits the unit to be dry `fired (no vaccine in the vaccine pump) with no mechanical damage occurring to any portion of the injection unit. This feature assures that there will be no break in service if the operator accidentally does not renew the vaccinev supply after the vaccine bottle in use Ihas been emptied. Even if air does enter into the vaccine pump, under these conditions an injection would be impossible because there is not enough pressure generated in the pump to administer an injection.
The use of a jeweled orifice as the ejection port has been found particularly advantageous, since it permits the machining of the opening to very close tolerances; and since the finished jeweled tip is semi-transparent, it is very easy to determine under examination with optical instruments whether or not the completed tip provides a smooth and uniform orifice. If a metal tip were used, it would be almost impossible to test its suitability directly by optical tests. In the present preferred embodiment, the diameter of the jeweled orifice 46 which has been found to be most advantageous in achieving the results of the invention in practice is .005 inch with a tolerance of plus .0002 inch minus zero.
A protective cap is provided to protect the jeweled tip and sterile gauze may be inserted in the cap to keep the vaccine pump section of the gun sterile during brief interruptions in use.
A sandpaper or abrasive disc 90 is providedY on the flat front surface of the nozzle 42. This disc has been found of great help in practice to prevent the ejection tip of the gun from slipping or sliding on the skin surface of a patient when an ejection is being made. Without such means to prevent slippage, perspiration on the skin surface makes` theV gun particularly susceptible to slippage, and if the gun slips when it is being red a severe cut can result from the knife-like actionl of the high pressure jet of fluid.
In the present embodiment (FIG. 2), sealing ring 92 is mounted in the closure member 40. Preferably, this is made of a plastic, such as Teflon, which, unlike a rubber sealing ring, is not susceptible to breaking off in small particles. This assembly provides a particularly effective seal since the closure member 40 is of a floating type. This floating feature provides that if the nozzle is loosely screwed onto the vaccine pump cylinder 32 by the operator, or if the plastic sealing ring flattens in use, as is normal, no loss of sealing efliciency between the jet nozzle and the pump cylinder occurs. When an injection is red, the thrust of the vaccine propels the iloating closure member forward with suflicient force to automatically maintain an excellent hydraulic seal between these members. This feature is of prime importance in insuring that all vaccine is ejected through the orifice, with proper pressure and velocity, and that none leaks past the threaded joint between nozzle and cylinder to reduce the effective dose and depth of penetration of the vaccine.
The vaccine inlet valve 48 and its supporting member 50'are mounted somewhat toward the rear of the gun. This arrangement keeps the shooting end of the gun clear and uncluttered so that the operator has an unobstructed view of the shooting end as it is placed in contact with the skin of the patient.
The vaccine pump is self-priming, which is an advantageous feature of the invention in practice. After loading'a new bottle of vaccine onto the device, the operator may purgethewaccine'pump of-air'andfplace it in condition to lire an injection by merelyV shootingit into the air twice.
Anotheradvantageous feature of thepresent embodiment is that'the ball of the vaccine inlet valve 48 `floats' in the valve chamber and is free to rotate. On the feed or inlet cycle ofthe vaccine pump, the ball permits the free` flow of vaccine into the vaccine feed tube through-a seriesI of slots 53 at the rear end of the tube. When the gun isred, however, the pressure created in the vaccine chamber 39 transmitted through the feed tube SZ forces the ball of the inlet valve 48 tightly against its seat in the Valve chamber and prevents any backow of fluid through the vaccine extracting tube 54;. The seat of the valve 48 is designed so that a substantial surface of the ball is in contact with the seat when the Valve is acting as a check; this reduces wear on the ball itself to a minimum. Accordingly, the latter feature and the design which permits the ball to rotate freely between cycles of the vaccine pump insure a long life for the valve in spite of its small size valve and subjection to tremendous pressure every time the gun is fired.
In operation, the operator controls the dosage of vaccine to be administered by turning the dosage adjusting screw 24 through the knob 2S. the adjusting screw 24 is moved towards the rear of the gun, and when a smaller dose is desired, the screw is moved toward the front of the gun. As the screw 24 is moved toward the front of the gun, it places the spring 16A underpartial compression. The pressure relief valve on the hydraulic pump is set to operate when the spring 16 is fully f compressed. l-f the dosage adjusting screw has already partially compressed the spring 16, it is obvious that the vaccine pump piston 36 will only move as far to the rear of the gun under hydraulic fluid pressure as isnecessary to complete compression of the spring 16. Accordingly, the degree to which the vacuum pump piston 36 moves to the rear can be directly controlled by the dosage adjusting screw 21%, and the degree to which the piston moves to the rear obviously determines the amount of vaccine drawn into the vaccine pump chamber 39 and the amount which is ejected upon tiring.
In practice, the extent to which the spring 16 is finally compressed is determined by the magnitude of the hydraulic uid pressure, which, in turn, is controlled by the pressure relief valve on the hydraulic fluid pump (not shown). Regardless of dosage to be administered, the spring 16 is compressed to the same degree each time the gun is cocked. This characteristic insures that the vaccine ejection force will always be the same at the instant the firing trigger is depressed, no matter what Volume dose is being administered. Screwing in the dosage adjusting screw 24'merely pre-compresses the firing spring 16 mechanically so that the hydraulic fluid will only be required to further compress the spring a short distance before the gun is fully cocked. If the dosage adjusting screw is turned in all the way, only a very slight further compression of the spring is possible, and in the present embodiment, the vaccine piston 36 can only move back the equivalent of 0.1 cc. of vaccine dose. Conversely, if the dosage adjusting screw is turned out all the way, the spring must be compressed through its full acting distance by the hydraulic system, and in the present embodiment, a 1.0 cc. dose will be administered. An interior shoulder 23` of hub of the cap 22 acts as a positive stop to prevent the dosage adjusting screw 24 from being turned in too far.
Of course, the characteristic last described is an important advantage of the present embodiment, since it guarantees that regardless of the size of the dose, the injection force at thevstart of the ring stroke is always the same and imparts to the jet of inoculating fluid the correct speed and pressure for insuring an eifective hypodermic injection.
The invention in its broader aspects is not limited to the specific mechanisms shown and described, but also includes Within the scope of the accompanying claims When a larger dose is desiredany departures made from such mechanisms which do not depart from the principles of the invention and which do not sacrifice its chief advantages.
1. A hydraulic-powered hypodermic jet injection instrument having a body with Ia hydraulic chamber and an inoculating fluid chamber, a hydraulic piston reciprocally mounted in the hydraulic chamber, means for biasing the hydraulic piston into a forward position in the hydraulic chamber, an inoculating fluid plunger reciprocally mounted in the inoculating fluid chamber, means connecting the inoculating fluid piston to the hydraulic piston so .that vthe inoculating fluid piston moves in response to movement of the hydraulic piston, a source of hydraulic fluid under pressure, means normally providing a path for continual flow of fluid through a portion of the instrument, means for `diverting the fluid to the hydraulic chamber, whereby pressure on the fluid is raised sufficiently yto overcome the forward bias on the hydraulic piston, and means for releasing the fluid from the hydraulic chamber.
2. 'Ihe invention as `defined in claim l, which includes means for variably and continuously controlling the volume of the inoculating fluid chamber.
3. The invention as defined in claim l, which includes an inoculating fluid reservoir, a passageway leading from the reservoir to the inoculating huid chamber, and valve means to prevent back flow of inoculating fluid from the inoculating fluid chamber to the reservoir through the passageway.
4. The invention as defined in claim 1, which also includes means visible from the exterior of the body to indicate the position of the inoculating fluid piston in the inoculating fluid chamber.
5. The invention as defined in claim l, in which the inoculating fluid chamber and the inoculating fluid pistn include means by which they may be readily detached from the body for sterilization.
6. The invention as defined in claim l, in which the inoculating fluid chamber has an outlet orifice formed from a jewel.
7. The invention as defined in claim 1, in which the inoculating fluid chamber has an outlet orifice of greatly reduced cross-sectional area from the cross-sectional area of the inoculating fluid chamber, and which also includes valve means for preventing entry of air into the inoculating fluid chamber through the orifice upon rearward movement of the inoculating fluid piston, the valve means readily opening under inoculating fluid pressure upon forward movement of the inoculating fluid piston to permit inoculating fluid to be ejected through the outlet orifice.
8. The invention as defined in claim l, in which the inoculating fluid chamber has an outlet orifice, and which also includes a sealing member in the Iforward chamber between the inoculating fluid piston and the orifice, the sealing member being axially-movable under inoculating fluid pressure exerted by the action of the inoculating fluid piston against inoculating fluid -in the inoculating fluid chamber, a resilient seal carried in the forward end of the sealing member, whereby when the sealing member moves axially forward under inoculating fluid pressure, the resilient seal a'buts against the forward inner wall of the inoculating fluid chamber and effects a fluid tight seal in the inoculating fluid chamber around the orifice.
9. The invention as defined in claim 1, in which the inoculating fluid chamber has an outlet orifice, and which also includes an abrasive surface on the front of the body adjacent to the outlet portion of the outlet orifice.
10. The invention as defined in claim 1, in which the 10 means for releasing the fluid from the hydraulic chamber includes a conduit having a restricted portion which provides hydraulic damping of the forward movement of the hydraulic piston.
11. A hydraulic-powered hypodermic jet injection instrument having a body with a hydraulic chamber and an inoculating fluid chamber, a hydraulic piston reciprocally mounted in the hydraulic chamber, means for biasing the hydraulic piston into a forward position in the hydraulic chamber, an inoculating fluid piston reciprocally mounted in the inoculating fluid chamber, means connecting the inoculating fluid piston to the hydraulic piston so that the inoculating fluid piston moves in response to movement of the hydraulic piston, a source of hydraulic fluid, an inlet conduit from the source of fluid into the instrument, an outlet conduit for returning the fluid to the source from the instrument a by-pass interconnecting the inlet conduit and the outlet conduit within the instrument, the source of fluid being under pressure whereby there is continual flow of fluid from the source through the inlet conduit into the instrument, through the by-pass, and then through the outlet conduit back to the source, both the inlet conduit and the outlet conduit being connected to the hydraulic chamber, the by-pass being located closer to the source than the hydraulic chamber, means for diverting the fluid from the by-pass through the inlet conduit to the hydraulic chamber whereby the pressure on the fluid is raised sufliciently to overcome the forward bias of the hydraulic piston, check valve means for trapping the fluid in the hydraulic chamber, and means for releasing the check valve means to permit the fluid to flow back to the source through the outlet conduit.
l2. A hydraulic-powered hypodermic jet injection instrument having a body with a hydraulic chamber an inoculating fluid chamber, a hydraulic piston reciprocally mounted in the hydraulic chamber, a spring biasing the hydraulic piston into a forward position in the hydraulic chamber, an inoculating fluid -piston reciprocally mounted in the inoculating fluid chamber, means connecting the inoculating fluid piston lto the hydraulic piston so that the inoculating fluid piston moves in response to movement of the hydraulic piston, a source of hydraulic fluid under pressure, an inlet conduit in the instrument for directing fluid from the source to the hydraulic chamber, an ou-tlet condui-t in the instrument for relasing fluid from the hydraulic chamber and returning it to the source, a bypass interconnecting the inlet and outlet conduits, a normally-open valve means permitting continual flow of the fluid through the by-pass, means for selectively closing the normally-open valve means to divert fluid flowing through the by-pass and cause it to flow through the inlet conduit into the hydraulic chamber to act against the hydraulic piston causing compression of the spring and storage of energy within the spring, check valve means in the inlet conduit to trap fluid within the hydraulic chamber and lock the hydraulic piston in a retracted position, normally-closed valve means in the outlet conduit, and means for selectively opening Athe normally-closed valve means to release fluid from the hydraulic chamber and permit it to 4flow through the outlet conduit releasing energy stored in the spring and allowing the spring to drive the hydraulic piston forward in the hydraulic chamber.
References Cited in the ille of this patent UNITED STATES PATENTS 1,831,668 Iuhl Nov. 10, 1931 2,653,605 Hein Sept. 29, 1953 2,821,193 Ziherl et al Jan. 28, 1958
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1831668 *||Apr 28, 1928||Nov 10, 1931||Juhl Chris E||Syringe|
|US2653605 *||Mar 22, 1951||Sep 29, 1953||Jr George N Hein||Injection device and ampoule|
|US2821193 *||Jul 22, 1952||Jan 28, 1958||Geoffrey W Walker||Multiple injection inoculator instrument|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3130723 *||Aug 15, 1960||Apr 28, 1964||Scherer Corp R P||Multidose jet injector|
|US3154223 *||Jul 12, 1961||Oct 27, 1964||Messmer Robert C||Spray can jet|
|US3189029 *||Jul 27, 1961||Jun 15, 1965||Amalgamated Dental Co Ltd||Hypodermic injection apparatus|
|US3292621 *||Jul 19, 1963||Dec 20, 1966||Banker Oscar H||Jet type protable inoculator|
|US3292622 *||Sep 21, 1964||Dec 20, 1966||Banker Oscar H||Power operated inoculator|
|US3406684 *||Sep 20, 1965||Oct 22, 1968||Yuryo Kikakuhin Kenkyusho Kk||Jet type, medical injection instrument|
|US3425413 *||Apr 26, 1966||Feb 4, 1969||Amalgamated Dental Co Ltd||Multi-dosage jet injector|
|US3490451 *||Nov 13, 1967||Jan 20, 1970||Scherer Corp R P||Hypodermic jet injector nozzle|
|US3507276 *||Aug 28, 1968||Apr 21, 1970||Catherine M Burgess||Jet injector|
|US3515130 *||Sep 18, 1967||Jun 2, 1970||Yuryo Kikakuhin Kenkyusho Kk||Jet-injection hypodermic device|
|US3675651 *||Feb 25, 1970||Jul 11, 1972||Meyer Louis C||Fluid-powered applicator for medicaments|
|US3714943 *||Dec 1, 1970||Feb 6, 1973||B Pansky||Medicament injectors|
|US3805783 *||Sep 29, 1972||Apr 23, 1974||Ismach A||Hand powered hypodermic jet injector gun|
|US3859996 *||Jul 18, 1973||Jan 14, 1975||Mizzy Inc||Multi-dose injector|
|US4103684 *||Dec 30, 1976||Aug 1, 1978||Aaron Ismach||Hydraulically powered hypodermic injector with adapters for reducing and increasing fluid injection force|
|US4266541 *||Sep 17, 1979||May 12, 1981||Halen-Elliot Do Brazil Industria E Comercio Equipamentos De Precisao Ltda.||Pressure hypodermic injector for intermittent vaccination|
|US4328796 *||Jan 3, 1980||May 11, 1982||Haekkinen Taisto||Respiration pacemaking valve for resuscitation apparatus such as respirators|
|US4403609 *||Feb 24, 1981||Sep 13, 1983||Cohen Edgar C||Vacuum-compression injector|
|US4411650 *||Apr 14, 1982||Oct 25, 1983||Hoechst Aktiengesellschaft||Piston pump for needle-less injection instruments|
|US4421508 *||Jul 8, 1981||Dec 20, 1983||Cohen Edgar C||Vacuum-compression injector|
|US4680027 *||Dec 12, 1985||Jul 14, 1987||Injet Medical Products, Inc.||Needleless hypodermic injection device|
|US4913699 *||Mar 14, 1988||Apr 3, 1990||Parsons James S||Disposable needleless injection system|
|US5024656 *||Aug 30, 1988||Jun 18, 1991||Injet Medical Products, Inc.||Gas-pressure-regulated needleless injection system|
|US5599302 *||Jan 9, 1995||Feb 4, 1997||Medi-Ject Corporation||Medical injection system and method, gas spring thereof and launching device using gas spring|
|US5643211 *||Feb 29, 1996||Jul 1, 1997||Medi-Ject Corporation||Nozzle assembly having a frangible plunger|
|US5697917 *||Feb 29, 1996||Dec 16, 1997||Medi-Ject Corporation||Nozzle assembly with adjustable plunger travel gap|
|US5722953 *||Feb 29, 1996||Mar 3, 1998||Medi-Ject Corporation||Nozzle assembly for injection device|
|US5769138 *||Apr 1, 1996||Jun 23, 1998||Medi-Ject Corporation||Nozzle and adapter for loading medicament into an injector|
|US5782802 *||Jan 30, 1997||Jul 21, 1998||Vitajet Corporation||Multiple use needle-less hypodermic injection device for individual users|
|US5800388 *||Feb 29, 1996||Sep 1, 1998||Medi-Ject Corporation||Plunger/ram assembly adapted for a fluid injector|
|US5846233 *||Jan 9, 1997||Dec 8, 1998||Medi-Ject Corporation||Coupling device for medical injection system|
|US5865795 *||Feb 29, 1996||Feb 2, 1999||Medi-Ject Corporation||Safety mechanism for injection devices|
|US5875976 *||Dec 24, 1996||Mar 2, 1999||Medi-Ject Corporation||Locking mechanism for nozzle assembly|
|US5891085 *||Jan 9, 1997||Apr 6, 1999||Medi-Ject Corporation||Nozzle assembly with lost motion connection for medical injector assembly|
|US5899879 *||Dec 19, 1995||May 4, 1999||Genesis Medical Technologies, Inc.||Spring-actuated needleless injector|
|US5919159 *||Jan 9, 1997||Jul 6, 1999||Medi-Ject Corporation||Medical injection system and method, gas spring thereof and launching device using gas spring|
|US5921967 *||Dec 24, 1996||Jul 13, 1999||Medi-Ject Corporation||Plunger for nozzle assembly|
|US6068640 *||Feb 27, 1998||May 30, 2000||Medjet Inc.||Removal of corneal epithelium|
|US6083197 *||Oct 1, 1998||Jul 4, 2000||Umbaugh; Jerald C.||Spring-actuated needleless injector|
|US6210359||Jan 21, 2000||Apr 3, 2001||Jet Medica, L.L.C.||Needleless syringe|
|US6309371||Jul 26, 1999||Oct 30, 2001||Medi-Jet Corporation||Injection-assisting probe for medical injector assembly|
|US6565528||May 5, 2000||May 20, 2003||Scimed Life Systems, Inc.||Apparatus and method for delivering therapeutic and diagnostic agents|
|US6602222||Oct 13, 2000||Aug 5, 2003||Cambridge Biostability Ltd.||Disposable injection device|
|US6626871||Oct 10, 2000||Sep 30, 2003||Felton International, Inc.||Method and apparatus for removing cap from medical device|
|US6641553 *||Jun 2, 2000||Nov 4, 2003||Boston Scientific Corporation||Devices and methods for delivering a drug|
|US6676630||Jun 4, 2002||Jan 13, 2004||Bioject Medical Technologies, Inc.||Needle-free injection system|
|US6770054||Nov 21, 2000||Aug 3, 2004||Felton International, Inc.||Injector assembly with driving means and locking means|
|US6802826||Oct 10, 2000||Oct 12, 2004||Felton International, Inc.||Universal anti-infectious protector for needleless injectors|
|US6883222||Oct 16, 2002||Apr 26, 2005||Bioject Inc.||Drug cartridge assembly and method of manufacture|
|US6939323||Jul 19, 2002||Sep 6, 2005||Massachusetts Institute Of Technology||Needleless injector|
|US7029457||Oct 11, 2002||Apr 18, 2006||Felton International, Inc.||Jet injector with hand piece|
|US7108675||Oct 29, 2001||Sep 19, 2006||Antares Pharma, Inc.||Injection-assisting probe for medical injector assembly|
|US7147633||Mar 14, 2002||Dec 12, 2006||Boston Scientific Scimed, Inc.||Method and apparatus for treatment of atrial fibrillation|
|US7211041||Mar 25, 2005||May 1, 2007||Boston Scientific Scimed, Inc.||Apparatus and method for delivering therapeutic and diagnostic agents|
|US7238167||Jan 13, 2004||Jul 3, 2007||Bioject Inc.||Needle-free injection system|
|US7425204||Apr 28, 2005||Sep 16, 2008||Massachusetts Institute Of Technology||Needleless injector|
|US7442182||Oct 25, 2004||Oct 28, 2008||Bioject, Inc.||Spring powered needle-free injection system|
|US7449009 *||Jun 13, 2003||Nov 11, 2008||Primojex Gmbh||Device for needle-free injection of a medium into the tissue of a human or an animal, device for needle free production of an injection channel and method for the needle free injection of a medium in the tissue|
|US7530975||Sep 8, 2003||May 12, 2009||Massachusetts Institute Of Technology||Measuring properties of an anatomical body|
|US7618393||Nov 13, 2006||Nov 17, 2009||Pharmajet, Inc.||Needle-less injector and method of fluid delivery|
|US7699802||May 3, 2005||Apr 20, 2010||Pharmajet, Inc.||Needle-less injector|
|US7833189||Feb 13, 2006||Nov 16, 2010||Massachusetts Institute Of Technology||Controlled needle-free transport|
|US7887506||Nov 21, 2000||Feb 15, 2011||Pulse Needlefree Systems, Inc.||Safety mechanism to prevent accidental patient injection and methods of same|
|US8105270||May 12, 2009||Jan 31, 2012||Massachusetts Institute Of Technology||Measuring properties of an anatomical body|
|US8172790||Aug 31, 2007||May 8, 2012||Massachusetts Institute Of Technology||Needle-free injector device with autoloading capability|
|US8187251||Oct 31, 2006||May 29, 2012||Boston Scientific Scimed, Inc.||Methods of treating cardiac arrhythmia|
|US8328755||Oct 18, 2010||Dec 11, 2012||Massachusetts Institute Of Technology||Controlled needle-free transport|
|US8398583||Sep 10, 2010||Mar 19, 2013||Massachusetts Institute Of Technology||Method and apparatus for extraction of a sample from a sample source|
|US8529500||Jun 16, 2011||Sep 10, 2013||Pharmajet, Inc.||Needle-less injector and method of fluid delivery|
|US8758271||Aug 31, 2010||Jun 24, 2014||Massachusetts Institute Of Technology||Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties|
|US8992466||Dec 7, 2012||Mar 31, 2015||Massachusetts Institute Of Technology||Controlled needle-free transport|
|US9125990||Dec 3, 2010||Sep 8, 2015||Massachusetts Institute Of Technology||Bi-directional motion of a lorentz-force actuated needle-free injector (NFI)|
|US20020058907 *||Oct 29, 2001||May 16, 2002||Medi-Ject Corporation||Injection-assisting probe for medical injector assembly|
|US20030083611 *||Jul 19, 2002||May 1, 2003||Massachusetts Institute Of Technology||Needleless injector|
|US20030088207 *||Oct 11, 2002||May 8, 2003||Felton International, Inc.||Jet injector with hand piece|
|US20040074076 *||Oct 16, 2002||Apr 22, 2004||Bioject Inc.||Drug cartridge assembly and method of manufacture|
|US20040106893 *||Sep 8, 2003||Jun 3, 2004||Massachusetts Institute Of Technology||Measuring properties of an anatomical body|
|US20040106894 *||Sep 8, 2003||Jun 3, 2004||Massachusetts Institute Of Technology||Needleless drug injection device|
|US20040199106 *||Jan 13, 2004||Oct 7, 2004||Sergio Landau||Needle-free injection system|
|US20050119608 *||Oct 25, 2004||Jun 2, 2005||Sergio Landau||Spring powered needle-free injection system|
|US20050171474 *||Mar 25, 2005||Aug 4, 2005||Scimed Life Systems||Apparatus and method for delivering therapeutic and diagnostic agents|
|US20050245859 *||Jun 13, 2003||Nov 3, 2005||Peter Eichhorst||Device for needle-free injection of a medium into the tissue of a human or an animal, device for needle free production of an injection channel and method for the needle free injection of a medium in the tissue|
|US20050256448 *||Apr 28, 2005||Nov 17, 2005||Massachusetts Institute Of Technology||Needleless injector|
|US20060287631 *||May 23, 2006||Dec 21, 2006||Leon Nathaniel J||Universal protector cap with auto-disable features for needle-free injectors|
|US20070027428 *||Jun 15, 2006||Feb 1, 2007||Pharmajet, Inc.||Vial system and method for needle-less injector|
|US20070129693 *||Nov 13, 2006||Jun 7, 2007||Hunter Ian W||Controlled needle-free eye injector|
|US20070191758 *||Feb 13, 2006||Aug 16, 2007||Hunter Ian W||Controlled needle-free transport|
|US20070191762 *||Jul 21, 2005||Aug 16, 2007||Kerry Quinn||Needleless injector and ampule system|
|US20080009788 *||Feb 10, 2006||Jan 10, 2008||Hunter Ian W||Surface injection device|
|US20080281261 *||May 3, 2005||Nov 13, 2008||Genesis Medical Technologies, Inc.||Needle-less injector|
|CN100435869C||Oct 18, 2002||Nov 26, 2008||麻省理工学院||Needleless injector|
|EP0063340A1 *||Apr 9, 1982||Oct 27, 1982||Hoechst Aktiengesellschaft||Needleless injection apparatus|
|EP2896420A1||Dec 9, 2014||Jul 22, 2015||Dante Lorini||Apparatus for needleless transdermal inoculation of medicaments|
|WO1982002835A1 *||Feb 24, 1982||Sep 2, 1982||Edgar C Cohen||Vacuum-compression injector|
|WO2003039635A2 *||Oct 18, 2002||May 15, 2003||Massachusetts Inst Technology||Needleless injector|
|U.S. Classification||604/71, 239/337|
|International Classification||A61M5/20, A61M5/30|
|Cooperative Classification||A61M5/30, A61M5/204|