|Publication number||US3060924 A|
|Publication date||Oct 30, 1962|
|Filing date||Jun 1, 1960|
|Priority date||Jun 1, 1960|
|Publication number||US 3060924 A, US 3060924A, US-A-3060924, US3060924 A, US3060924A|
|Inventors||Rush Joseph C|
|Original Assignee||Rush Joseph C|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (6), Referenced by (77), Classifications (11)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Oct. 30, 1962 J. RUSVH 3,060,924
APPARATUS FOR APP TION OF RADIO-ACTIVE SUBSTANCE 0 ELVIC CANCER Filed June 1, 1960 2 Sheets-Sheet 1 FIG l.
C. RUSH 3,060,924 LICATION OF RADIO-ACTIVE TO PELVIC CANCER J.. APP NOE Oct. 30, 1962 APPARATUS FOR SUBSTA 2 Sheets-Sheet 2 Filed June 1, 1960 INVENTOR Josqvfi L flasfi 3,060,924 APPARATUS 130R APPLHIATION OF RADIQ- ACTIVE SUBSTANCE T PELVIC CANQER Joseph C. Rush, St. Petershurg, Fla. (1611 Dauphine Lane, St. Louis 22, Mo.) Filed June l, 1966, Ser. No. 33,282 3 flaims. Cl. 128-12) The present invention relates to an improved apparatus for applying radio-active substances within the body, such as the cervical-vaginal cavities.
The principal. object of the invention is the provision of an improved apparatus for relatively easily positioning radio-active substances Within the uterus and vaginal tract so that the most effective dosages can be applied to the affected areas, such as the cervix, While shielding unaffected areas, such as the colon, bladder and urinary tract, from detrimental radiation and to maintain the radio-active substances in the required position with little or no discomfort to the patient.
In the preferred form of the invention, a shank-like structure is provided which may be inserted into the Vaginal tract and extended into the uterus, and which carries on its leading end one or more containers or pods of radio-active material which are supported or attached to the shank by a flexible connection, preferably in the form of a tightly coiled spring having a given angular bend conforming to normal disposition of the uterus relative to the vaginal tract but suificiently flexible so that the angular disposition of the radioactive substance container relative to the shank proper can shift according to the particular disposition of the organs involved.
Another object of the invention is the provision of an apparatus for applying radio-active substances to body cavity walls comprising a shank preferably carrying a pair of capsules or pods containing radio-active material, each supported on the outer end of an arm alongside of the shank, which arm is resiliently urged outwardly from the shank to position the radio-active material adjacent to the cervix, means being provided on the lower part of the shank for actuating the arms to move the pods toward the shank to facilitate the insertion and removal of the applicator from the patient and to regulate the outward thrust of the arms so that the lateral pressure of the pods against the walls of the body cavity can be controlled.
Still another object of the invention is the provision of an improved radio-active material applicator of the type described in which the capsules or pods carried on the arms are pivotally attached thereto whereby they can shift positions to accommodate more readily to the particular body cavity contour. Preferably, the capsules are cylindrical and are attached to the arms so that their axes extend generally parallel to that of the shank, thereby minimizing displacement of body tissue and at the same time providing ample radiation to the affected parts.
A further object of the invention is the provision of a radio-active material bearing pod having longitudinally extending shielded portions to prevent or minimize radiation to organs above or below the area to be treated. For example, in the preferred embodiment of the invention, the apparatus is utilized to treat the cervix and adjacent areas with radio-active material without adversely affecting the bladder and urinary tract or the colon, which lie immediately above and below these areas.
Other objects of the invention will be apparent from the following description of a preferred form of the 3,%,9Z4 Patented Oct. 30, 1962 invention, reference being made to the accompanying drawings, wherein:
FIG. 1 is a view of an improved applicator embodying the invention, and being shown positioned in the vaginal tract and uterus, shown in section, to treat the uterus and cervix, including surrounding areas, the arms supporting the capsules of radio-active material being shown in retracted position to facilitate insertion or removal of the applicator from the patient;
FIG. 2 is a view similar to FIG. 1, but showing the arms carrying radio-active capsules in a laterally extended position;
FIG. 3 is a view, partly in section, of a part of the apparatus shown in FIGS. 1 and 2, but on a langer scale;
FIG. 4 is a view similar to that shown in FIG. 2 but at right angles thereto, a part of the apparatus being shown broken away;
FIG. 5 is a fragmentary view, partly in section, of the apparatus;
FIG. 6 is a sectional view taken along line 66 of FIG. 5, and
FIGS. 7 and 8 are sectional views taken along lines 77 and 88, respectively, of FIG. 5.
In general, the apparatus comprises a shank 10 which can be inserted in the vaginal tract and which carries a radio-active material bearing container 11, referred to as the uterine tandem, and a pair of radio-active material containing capsules or pods 12 and 13, referred to as the vaginal sources. As may be seen in FIGS. 1, 2 and 4, shank 10 may be inserted into the vaginal tract, indicated at B, and the uterine tandem 11, which is the leading end, is inserted through the cervix C so that the vaginal sources or pods 12 and 13 will lie adjacent the cervix with the upper ends abutting the latter.
In the preferred form of the invention, shank 10 comprises a stock portion 14 having a stem 15 projecting therefrom which has a threaded neck 16 at the outer end thereof onto which one end of a coil spring 17 is threaded, and a handle 18 is provided at the lower end of the stock. Stock 14 has a threaded section 20 for receiving an adjusting nut 22 thereon, the purpose of which is explained hereinafter. Preferably, the stock 14 and handle 18 are hollow to minimize the weight of the apparatus.
Uterine tandem 11 preferably comprises several tubular sections assembled according to the desired length of the tandem and to carry an appropriate dosage of radio-active material, and as shown includes a tubular base section 11a having a threaded stem 11b projecting from the lower end, which is closed, and which is threaded into an end portion of coil spring 17. In the form shown, the outer open end of base section 11a is necked and threaded externally to be threaded into the lower end of a second tubular section 110, and a second tubular section lid is threaded on section 110. Section lid is closed by a cap lle threaded thereon, as seen in FIG. 3. These tubular sections thus asesmbled form a cylindrical container to receive needles of radio-active material, such as cesium, radium or cobalt, not shown. Other similar tubular sections .of suitable capacities and lengths could be assembled to form a tandem of a different desired length and also to accommodate a different dosage of radio-active material. As seen by reference to FIGS. 1, 2 and 4 of the drawings, the diameter of the uterine tandem 11 is small enough to be more readily received through the cervix and into the uterus. Preferably, spring 17 has a normal curvature or bend which corresponds to the usual angle between the longitudinal medians of the vaginal and uterine cavities, but the spring may flex universally to accommodate angles other than normal.
Pods 12 and 13 are formed alike, and referring to pod 12 for a description thereof, the pod comprises a cylin drical casing 26 of a suitable material which will pass rays from radio-active material and which casing is closed at its upper end 27 and open at its lower end. The lower end portion of casing 26 is threaded to receive a cap 28 which preferably has a slot 29 therein by which the cap can be turned by a tool, such as a screw driver. Preferably, the inner side 39 of casing 26, which is next to I shank 10, is indented or flattened intermediate its ends,
as may be seen by reference to FIGS. and 6, and a stirrup 31 is attached to the flattened side to form pivotal means connecting the pod to a supporting arm, described more fully hereinafter. A plug 32, disposed inside casing 26, has a central bore 33, the upper end of which abuts a spacer 34 lying against the top of the casing, as viewed in FIG. 5, and the lower end of the bore is closed by cap 28 so that a suitable needle of radio-active material, not shown, may be carried in the bore. Referring to FIG. 6, lead shield members 36 and 37 extend lengthwise of the container 26 and their transverse cross-sectional shape is generally triangular so that radiation from the needle in bore 33 is shielded or minimized in the directions above and below the pod, as viewed in FIG. 6, and to the right and left as viewed in FIG. 4. The purpose of shields 36 and 37 is to prevent radiation from adversely aflecting the colon, bladder and urinary tract, which are located on opposite sides of the vaginal and uterine cavities, as mentioned previously. On the other hand, radiation may freely pass from the needle through the upper unshielded ends of the capsules 12 and 13 and outwardly into parametrial tissue laterally of the pods, as indicated by the arrows in FIGS. 2 and 6.
Pods 12 and 13 are supported on the outer ends of two blade type spring arms 40 and 41, the lower ends of which are attached to stock 14, and for this purpose have end sections 400 and 410 respectively, rectangular and in cross section and fitting into corresponding grooves 42 and 43 formed in opposite sides of the stock, and which are retained in these grooves by a sleeve 44 having its lower end threaded on the exterially threaded portion of the stock. Arms 40 and 41 are inherently biased outwardly relative to stock 14 but are limited in outward movement by a sleeve 46 which surrounds the stock and sleeve 44, and which is arranged to be moved longitudinally along the stock by nut 22 which is attached to the lower end of sleeve 46 by a sliding, rotary connection formed by a laterally projecting flange 48, formed on the lower end of sleeve 46, retained in an annular groove in the top of nut 22 formed by a turned in lip 49' at the open end of an undercut portion. It will be seen that by rotating nut 22, sleeve 46 is moved longitudinally of stock 14, and as the sleeve is moved upwardly along the stock, the open end edges of the sleeve draw arms 40 and 41 inwardly toward stem 15, as may be seen in FIG. 1. Conversely, as sleeve 46 is lowered relative to the stock as seen in FIG. 5, arms 40 and 41 are permitted to tend to spread from the center line of shank 14.
Pods 12 and 13 are attached to the outer ends of arms 40 and 41 so that they may pivot in a plane common to the shank and pods, as is illustrated by broken lines in FIG. 5 with reference to pod 12, and for this purpose, the outer end portions 50, 51 of the arms 40 and 41 are turned or twisted at 90 to the arms proper and extend through the stirrups 31. The outer ends of the arms have enlargement 40a and 41a, respectively, which prevent removal of the stirrups from the arms, and the lower edges of the stirrup engage the shoulders 40b and 41b formed by twisting arm portions 50 and 51 to retain the pods in place on the arms. The yokes, or outer walls, of stirrups 31 are tapered to permit the pivotal movement just described.
In using the apparatus, suitable needles of radio-active material, such as cesium 137, radium 226 or cobalt 60, are loaded into the vaginal sources and uterine tandem in the manner described, and sleeve 46 is then moved to its uppermost position by rotating nut 22 so as to cause the pods 12 and 13 to be drawn inwardly adjacent to stem 15 to facilitate insertion of the apparatus into the vaginal or uterine cavity. The insertion is made so that uterine tandem 11 enters through the cervix and into the uterus, as seen in FIGS. 1, 2 and 4. The upper ends of pods 12 and 13 engage the tissue adjacent to the cervix, and sleeve 45 is then moved to a lower position which permits arms 41) and 41 to spread, under their inherent bias, outwardly from stem 15, as may be seen by reference to FIG. 2, and the degree of force exerted outwardly by the arms can be regulated by longitudinal positioning of sleeve 46 in the manner described. Furthermore, the pivotal connection between arms 4%, 41 and pods 12 and 13 permits the pods to accommodate themselves somewhat to the contour of the tissue adjacent the cervix, thereby minimizing or avoiding areas of high pressure bearing on the tissues. The flexible connection 17 between shank 1t} and uterine tandem 11 permits the latter to flex, if necessary to accommodate the tandem to any angular disposition on the uterus relative to the vaginal cavity, in the event it is off from norm. The fact that the axes of pods 12 and 13 lie generally parallel to the axis of shank 1t} permits relatively easy insertion and removal of the apparatus from the vaginal cavity, and the form of the pods and their shielding elements 36 and 37 permit controlled and accurate radiation of the aflected areas while shielding other tissue or organs from adverse effects of the radiation.
The apparatus is readily removed from the body by moving sleeve 46 to the upper position, as shown in FIG. 1, which draws pods 12 and 13 inwardly toward stem 15, thereby reducing the over all diameter of the apparatus to a minimum for easy withdrawal thereof.
It circumstances indicate, the uterine tandem can be omitted by unscrewing spring 17 from neck 16, in which case the leading end of the shank 10 would not enter the cervix; however, the pods 12 and 13 would be disposed adjacent to the cervix in the manner shown and described.
It will be seen that the apparatus can be readily disassembled for cleaning by unthreading spring 17 from neck 16 and removing arms 40 and 41 by running nut 22, including sleeve 46, and sleeve 44 down the threaded stock for releasing the arms from the retaining grooves.
While but one form of the invention has been disclosed, it is to be understood that other forms, modifications and adaptations could be employed, all falling within the scope of the claims which follow.
1. Apparatus for applying radioactive materials to a body cavity having anterior and posterior portions with a restricted passage therebetween, said apparatus comprising a shank including a handle and a stock portion, a plurality of resiliently flexible arms each having one end attached to said stock portion and each tending to spread away from said shank, a plurality of pods for containing radioactive material each attached to the other end of one of said arms, said arms resiliently biasing said pods laterally away from said shank for engagement of said pods with the walls of said anterior cavity portion adjacent said restricted passage, adjusting means acting on said arms adjacent their attachment to said stock portion for adjustably increasing and decreasing the lateral biasing effect of said arms on said pods, a resiliently flexible member mounted on said stock portion and extending beyond said pods from between the outer ends thereof so as to be adapted to project through said restricted passage, and a tubular casing mounted by one end on said resiliently flexible member for support thereby in said posterior cavity portion, whereby said resiliently flexible member when in said restricted passage is adapted to flex to permit deflection of said tubular casing when in said posterior cavity portion with respect to said shank but resiliently tends always to align said tubular casing with said shank.
2. Apparatus as defined in claim 1 wherein said arms are two in number and lie in a plane common with said shank on opposite sides thereof, said pods being of cylindrical shape, and said attachment of said pods to said arms being by pivot means to permit movement of said pods with respect to said arms and in said plane.
3. Apparatus for applying radioactive materials to a body cavity having anterior and posterior portions with a restricted passage therebetween, said apparatus comprising a shank including a handle and a stock portion, a plurality of resiliently flexible arms each having one end attached to said stock portion and each tending to spread away from said shank, a plurality of pods for containing radioactive material each attached to the other end of one of said arms, said arms resiliently biasing said pods laterally away from said shank for engagement of said pods with the walls of said anterior cavity portion adjacent said restricted passage, adjusting means acting on said arms adjacent their attachment to said stock portion for adjustably increasing and decreasing the lateral biasing effect of said arms on said pods, a resiliently flexible member mounted on said stock portion and extending beyond said pods from between the outer ends thereof so as to be adapted to project through said restricted passage, and a tubular casing mounted by one end on said resiliently flexible member for support thereby in said posterior cavity portion, whereby said resiliently flexible member when in said restricted passage is adapted to flex to permit deflection of said tubular casing when in said posterior cavity portion with respect to said shank but resiliently tends always to return said tubular casing to a predetermined angular position with respect to said shank.
References Cited in the file of this patent UNITED STATES PATENTS 15 540,835 Gunning June 11, 1895 817,973 Hausmann Apr. 17, 1906 2,285,440 Kaiser June 9, 1942 2,888,917 Fordyce June 2, 1959 20 2,905,178 Hilzinger Sept. 22, 1959 FOREIGN PATENTS 281,869 Germany Feb. 3, 1915
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US540835 *||Jul 9, 1894||Jun 11, 1895||Veterinary|
|US817973 *||Jun 6, 1904||Apr 17, 1906||Caspar Friedrich Hausmann||Uterine dilator.|
|US2285440 *||Jan 22, 1941||Jun 9, 1942||Herman F Kaiser||Device for handling capsules containing radioactive substances|
|US2889917 *||Nov 30, 1954||Jun 9, 1959||Rca Corp||Apparatus for conveying articles in close spaced relationship|
|US2905178 *||Dec 19, 1956||Sep 22, 1959||Hilzinger Iii Paul||Surgical control device for controlling operating means inserted into a body cavity|
|*||DE281869C||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3323511 *||Mar 5, 1962||Jun 6, 1967||Holter Company||Radiation source applicator|
|US3438365 *||Mar 1, 1965||Apr 15, 1969||United Aircraft Corp||Radioactive seed containing xenon gas for medical treatment|
|US3789829 *||Jun 1, 1971||Feb 5, 1974||Hasson H||Vaginal radium applicator|
|US3807386 *||Apr 20, 1972||Apr 30, 1974||Commissariat Energie Atomique||Radioactive source applicator for utero-vaginal plesiocurietherapy according to the method of non-radioactive preparation|
|US3970073 *||Jan 30, 1975||Jul 20, 1976||Howlin Enterprises, Inc.||Positioning device for radiation treatment of cervical carcinoma|
|US4292960 *||Apr 30, 1979||Oct 6, 1981||Rca Corporation||Apparatus and method for application of radioactive and microwave energy to the body|
|US4331131 *||Dec 17, 1979||May 25, 1982||The Board Of Regents Of The University Of Nebraska||Method for treating carcinoma of the uterine cervix|
|US4819618 *||Mar 11, 1987||Apr 11, 1989||Liprie Sam F||Iridium/platinum implant, method of encapsulation, and method of implantation|
|US4957476 *||Jan 9, 1989||Sep 18, 1990||University Of Pittsburgh||Afterloading radioactive spiral implanter|
|US4976680 *||Oct 7, 1988||Dec 11, 1990||Hayman Michael H||Apparatus for in situ radiotherapy|
|US5084002 *||Aug 4, 1988||Jan 28, 1992||Omnitron International, Inc.||Ultra-thin high dose iridium source for remote afterloader|
|US5092834 *||Oct 12, 1990||Mar 3, 1992||Omnitron International, Inc.||Apparatus and method for the remote handling of highly radioactive sources in the treatment of cancer|
|US5227969 *||May 23, 1991||Jul 13, 1993||W. L. Systems, Inc.||Manipulable three-dimensional projection imaging method|
|US5295945 *||Aug 3, 1992||Mar 22, 1994||Beth Israel Hospital Assoc. Inc.||Garment and method for positioning and securing a radioactive implant internally within the female genital organs|
|US5575749 *||Sep 27, 1990||Nov 19, 1996||Omnitron International, Inc.||Ultra-thin high dose radioactive source wire|
|US6019718 *||May 30, 1997||Feb 1, 2000||Scimed Life Systems, Inc.||Apparatus for intravascular radioactive treatment|
|US6059713 *||Mar 5, 1998||May 9, 2000||Scimed Life Systems, Inc.||Catheter system having tubular radiation source with movable guide wire|
|US6059812 *||Mar 6, 1998||May 9, 2000||Schneider (Usa) Inc.||Self-expanding medical device for centering radioactive treatment sources in body vessels|
|US6071227 *||Jan 27, 1997||Jun 6, 2000||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6074338 *||Jun 28, 1994||Jun 13, 2000||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6099454 *||Mar 6, 1997||Aug 8, 2000||Scimed Life Systems, Inc.||Perfusion balloon and radioactive wire delivery system|
|US6110097 *||Mar 6, 1997||Aug 29, 2000||Scimed Life Systems, Inc.||Perfusion balloon catheter with radioactive source|
|US6117065 *||Jun 24, 1998||Sep 12, 2000||Scimed Life Systems, Inc.||Perfusion balloon catheter with radioactive source|
|US6146322 *||Oct 30, 1996||Nov 14, 2000||Schneider (Europe) Ag||Irradiating filament and method of making same|
|US6203485||Oct 7, 1999||Mar 20, 2001||Scimed Life Systems, Inc.||Low attenuation guide wire for intravascular radiation delivery|
|US6231494||Nov 17, 1997||May 15, 2001||Schneider (Europe) A.G.||Medical device with radiation source|
|US6234951||Jan 10, 1997||May 22, 2001||Scimed Life Systems, Inc.||Intravascular radiation delivery system|
|US6258019||Sep 8, 1999||Jul 10, 2001||Scimed Life Systems, Inc.||Catheter for intraluminal treatment of a vessel segment with ionizing radiation|
|US6264596||Nov 3, 1997||Jul 24, 2001||Meadox Medicals, Inc.||In-situ radioactive medical device|
|US6267775||Mar 6, 2000||Jul 31, 2001||Schneider (Usa) Inc.||Self-expanding medical device for centering radioactive treatment sources in body vessels|
|US6302865||Mar 13, 2000||Oct 16, 2001||Scimed Life Systems, Inc.||Intravascular guidewire with perfusion lumen|
|US6352501||Sep 23, 1999||Mar 5, 2002||Scimed Life Systems, Inc.||Adjustable radiation source|
|US6398708||Oct 28, 1998||Jun 4, 2002||Scimed Life Systems, Inc.||Perfusion balloon and radioactive wire delivery system|
|US6398709||Oct 19, 1999||Jun 4, 2002||Scimed Life Systems, Inc.||Elongated member for intravascular delivery of radiation|
|US6413203||Sep 16, 1998||Jul 2, 2002||Scimed Life Systems, Inc.||Method and apparatus for positioning radioactive fluids within a body lumen|
|US6416457||Mar 9, 2000||Jul 9, 2002||Scimed Life Systems, Inc.||System and method for intravascular ionizing tandem radiation therapy|
|US6422989||Nov 5, 1999||Jul 23, 2002||Scimed Life Systems, Inc.||Method for intravascular radioactive treatment|
|US6464625 *||Jun 23, 1999||Oct 15, 2002||Robert A. Ganz||Therapeutic method and apparatus for debilitating or killing microorganisms within the body|
|US6514191||Jan 25, 2000||Feb 4, 2003||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6582352||Jan 2, 2001||Jun 24, 2003||Schneider (Europe) A.G.||Medical appliance for treatment by ionizing radiation|
|US6599230||Mar 14, 2001||Jul 29, 2003||Scimed Life Systems, Inc.||Intravascular radiation delivery system|
|US6616629||Jun 14, 1999||Sep 9, 2003||Schneider (Europe) A.G.||Medical appliance with centering balloon|
|US6676590||Dec 8, 1997||Jan 13, 2004||Scimed Life Systems, Inc.||Catheter system having tubular radiation source|
|US7530941||Feb 2, 2004||May 12, 2009||Best Medical International, Inc.||X-ray and gamma ray emitting temporary high dose rate brachytherapy source|
|US7662082||Nov 4, 2005||Feb 16, 2010||Theragenics Corporation||Expandable brachytherapy device|
|US7736292||Oct 31, 2006||Jun 15, 2010||Cianna Medical, Inc.||Brachytherapy apparatus and methods of using same|
|US7862496||Mar 16, 2006||Jan 4, 2011||Cianna Medical, Inc.||Brachytherapy apparatus and methods for using them|
|US7862498||Oct 6, 2007||Jan 4, 2011||Cianna Medical, Inc.||Expandable brachytherapy apparatus and methods for using them|
|US7887476||Nov 8, 2006||Feb 15, 2011||Cianna Medical, Inc.||Helical brachytherapy apparatus and methods of using same|
|US8323171||Oct 4, 2007||Dec 4, 2012||Cianna Medical, Inc.||Brachytherapy apparatus and methods for using same|
|US8398534||Jan 22, 2010||Mar 19, 2013||Theragenics Corporation||Expandable brachytherapy device|
|US8475353||Aug 18, 2009||Jul 2, 2013||Cianna Medical, Inc.||Brachytherapy apparatus, systems, and methods for using them|
|US8517907||Nov 24, 2008||Aug 27, 2013||Cianna Medical, Inc.||Expandable brachytherapy apparatus and methods for using them|
|US8562504||May 7, 2010||Oct 22, 2013||Theragenics Corporation||Expandable brachytherapy device|
|US8568284||Feb 22, 2010||Oct 29, 2013||Theragenics Corporation||Expandable brachytherapy device|
|US8636635||Aug 18, 2009||Jan 28, 2014||Cianna Medical, Inc.||Brachytherapy apparatus, systems, and methods for using them|
|US8684899||Jan 27, 2010||Apr 1, 2014||Theragenics Corporation||Expandable brachytherapy device|
|US8690746||Jun 29, 2009||Apr 8, 2014||Theragenics Corporation||Expandable brachytherapy device|
|US8758213 *||Apr 1, 2009||Jun 24, 2014||Loren Godfrey, Jr.||Minimally invasive applicators for robotic and non-robotic-assisted intraoperative radiotherapy|
|US8771161||Dec 18, 2009||Jul 8, 2014||Cianna Medical, Inc.||Expandable brachytherapy apparatus and methods for using them|
|US8795145||May 7, 2009||Aug 5, 2014||Cianna Medical, Inc.||Brachytherapy apparatus and methods for using same|
|US8808156 *||May 5, 2011||Aug 19, 2014||Loren Godfrey, Jr.||Minimally invasive applicator for intraoperative radiotherapy|
|US8814775||Mar 18, 2010||Aug 26, 2014||Cianna Medical, Inc.||Expandable brachytherapy apparatus and methods for using them|
|US8858415||Apr 21, 2010||Oct 14, 2014||Cianna Medical, Inc.||Brachytherapy apparatus and methods for using them|
|US8979725||May 23, 2012||Mar 17, 2015||Mark A. D'Andrea||Brachytherapy tandem and ovoid implantation devices and methods|
|US9067063||Nov 3, 2010||Jun 30, 2015||Cianna Medical, Inc.||Expandable brachytherapy apparatus and methods for using them|
|US9072893||Jun 1, 2007||Jul 7, 2015||Cianna Medical, Inc.||Expandable brachytherapy apparatus and methods for using them|
|US9149653||Mar 6, 2013||Oct 6, 2015||Mark A. D'Andrea||Brachytherapy devices and methods for therapeutic radiation procedures|
|US20020099255 *||Nov 7, 2001||Jul 25, 2002||Liprie Sam F.||Afterloader apparatus|
|US20040254418 *||Feb 2, 2004||Dec 16, 2004||Munro John J.||X-ray and gamma ray emitting temporary high dose rate brachytherapy source|
|US20070106108 *||Mar 16, 2006||May 10, 2007||Hermann George D||Brachytherapy Apparatus and Methods for Using Them|
|US20070167664 *||Oct 31, 2006||Jul 19, 2007||Hermann George D||Brachytherapy apparatus and methods of using same|
|US20080027266 *||Oct 4, 2007||Jan 31, 2008||Cianna Medical, Inc.||Brachytherapy apparatus and methods for using same|
|US20080091055 *||Oct 6, 2007||Apr 17, 2008||Cianna Medical, Inc.||Expandable brachytherapy apparatus and methods for using them|
|US20090156882 *||Nov 24, 2008||Jun 18, 2009||Cianna Medical, Inc.||Expandable brachytherapy apparatus and methods for using them|
|WO1992000776A1 *||Jul 12, 1991||Jan 23, 1992||Mallinckrodt Medical Inc||Device for introducing a radioactive source into the body|
|WO1993018713A1 *||Mar 14, 1992||Sep 30, 1993||James F Hodgson||Uterine retractor|
|U.S. Classification||600/6, 600/1, 250/492.1, 600/235, 600/3|
|International Classification||A61N5/10, A61M31/00|
|Cooperative Classification||A61M31/00, A61N5/1016|
|European Classification||A61N5/10B4G, A61M31/00|