|Publication number||US3170462 A|
|Publication date||Feb 23, 1965|
|Filing date||Jan 5, 1962|
|Priority date||Jan 5, 1962|
|Publication number||US 3170462 A, US 3170462A, US-A-3170462, US3170462 A, US3170462A|
|Inventors||Hall Victor C|
|Original Assignee||Merck & Co Inc|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (5), Referenced by (35), Classifications (12)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Feb. 23, 1965 V. C. HALL AEROSOL OPHTHALMIC DEVICE Filed Jan. 5, 1962 ENT OR C. LL
AT EY United States Patent 3,170,462 AEROSOL OPHTHALMIC DEVICE Victor C. Hall, Media, Pa., assignor to Merck & Co., Inc., Rahway, N.J., a corporation of New Jersey Filed Jan. 5, 1962, Ser. No. 164,494 1 Claim. (Cl. 128-173) This invention relates to a device for applying a medicament to the eye, and particularly, a medicament con tained within an aerosol.
The principal object of the invention is to provide a simple and inexpensive device that will apply the aerosolcontained medicament to the eye in an effective and safe manner.
The various features of the device by which this principal object is achieved will be evident from the following description, in conjunction with the accompanying drawings, in which:
FIGURE 1 is a view, in perspective, of the complete device and showing the manner of its use;
FIGURE 2 is a vertical section along the axis of the device, with an aerosol cartridge in position;
FIGURE 3 is a plan view of the outer end of the device, with the aerosol discharge stem shown in section and with a portion of the device broken away to show its interior construction;
FIGURE 4 is a vertical cross-sectional view of the device taken along the line 4-4 of FIGURE 2; and
FIGURE 5 is a vertical cross-sectional view of the device taken along the line 5-5 of FIGURE 3, with the aerosol discharge stem removed.
Referring to FIGURE 1 of the drawings, the eyeapplying aerosol device generally designated consists of an eyecup 11, a tube-like block 12, and an aerosol cartridge 13 containing the medicament under a suitable pressure. The discharge stem 14 of the aerosol cartridge fits into an aperture 15 in the outer end 16 of the tubelike block 12.
When the upper end of the aerosol cartridge 13 and the under surface of the outer end 16 of the tube-like block 12 are grasped between the thumb and forefinger of the hand, as shown in FIGURE 1, and compressed, the medicament within the aerosol cartridge is discharged as a mist through its stem 14 into the tube-like block 12, and from there the mist is guided by the eyecup 11 to the eye 17 of the person whose face is shown in outline in FIGURE 1.
The aerosol cartridge 13 contains a metering valve (not shown) effective to discharge a small, definite amount of the medicament within the cartridge each time the cartridge is moved toward the outer end 16 of the tube-like block 12 as a result of the manual compression action referred to. After this amount of medicament is discharged, there is no further discharge of medicament while the cartridge is maintained depressed against the outer end 16 of the tube-like block 12. The cartridge 13 must be released so that it moves upwardly to its normal, uncompressed position, and then moved again to its depressed position, in order to discharge additional medicament. Such additional medicament will be a second small, definite amount of the medicament.
The end result is that the medicament is discharged from the aerosol cartridge in a single small burst of mist for each compressive action of the hand.
Metering valves for aerosols are well-known, and as they are not part of this invention, are not shown or described in detail.
This invention is primarily concerned with what is positioned between the aerosol discharge stem 14 and the 7 eye 17. This consists of the eyecup 11 (of conventional shape) and of the tube-like block 12.
surface of chamber portion 21 so that the aerosol con tainer may move along its axis toward the block 12 the full distance necessary to effect a discharge of medicament from the aerosol, without such movement being impeded by having some part of the aerosol container engage the block 12. Preferably, this is accomplished by having the aerosol-facing exterior surface 22 a substantially flat surface perpendicular to the axis of the aerosol discharge stem 14, and by positioning this surface along the axis of the aerosol discharge stem 14 a distance from the tip 23 of such stem that is sufficient to enable the outer end 16 of the block 12 to support the aerosol container, preferably in the inverted position shown. In the construction illustrated, this surface 22 is tangent to a circle whose radius is approximately one half the radius of the cylindrical exterior surface of the chamber portion 21.
Preferably, the outer end portion 16 of block 12 has a flattened surface 24 in the area most remote from the aerosol cartridge, where this portion 16 is engaged by the thumb of the person who uses the device in the manner shown in FIGURE 1.
Between surfaces 22 and 24, the outer end portion 16 of block 12 is of a solid material that is substantially impervious to gas and liquid, yet is readily formed with the apertures now to be described and which is inert to the medicament and other constituents in the aerosol cartridge. Preferably this is of a plastic material that is readily molded or cast to the shape and form desired.
Aperture 15 is a cylindrical aperture extending perpendicularly inwardly from the aerosol-facing surface 22 for receiving the discharge stem 14 of the aerosol cartridge 13. Before this aperture 15 reaches the axis of the cylindrical chamber portion 21, its diameter is reduced to form an annular shoulder 25 against which the tip 23 of the aerosol discharge stem 14 abuts. The aperture 15 continues inward, at a reduced diameter as shown at 26, to at least the axis of the cylindrical chamber portion 21, and preferably slightly beyond.
The side wall of the reduced diameter portion 26 of aperture 15 has a small lateral opening 27 about on the line of the axis of the cylindrical chamber portion 21 and extending toward the chamber portion 21. This lateral opening 27 connects with the end wall of an intermediate chamber 28, most of which is formed inside the outer end 16 of block 12 and which is preferably symmetrical in cross-section about the axis of the cylindrical chamber portion 21. In the construction illustrated, the cross-section of the intermediate chamber is rectangular with rounded ends, and with the long flat sides of the rectangle parallel to the aerosol-facing exterior surface 22 of outer end 16, as clearly shown in FIGURE 5.
The end of intermediate chamber 28 remote from the end wall having the lateral opening 27 therein, connects with one end of the main chamber 30 formed inside the cylindrical chamber portion 21 of the tube-like block 12. This main chamber 30 is considerably larger in volume than the intermediate chamber. Thus, in the construction illustrated the cross-section of the main chamber 30 is rectangular with rounded ends, with the chamber about four or five times longer, axially, then the intermediate chamber 28, about twice as large across the narrow trans- 0 verse dimension of the chamber 30 (i.e., parallel to the axially-extending annular lip 33 that overlays and fits snugly upon an interior annular lip 34 formed on the body of the chamber portion 21'. In the construction illustrated, the small end 31 of the eyecup fits around a neck 35 and against a shoulder 36 formed at the eyecup end of the collar 32. If desired, the eyecup 11 and the collar 32'maybe formed as a single integral unit.
There is thus provided two chambers in series (ie, in: termediate chamber 28 and main chamber 30) through which the medicament in mist form, as discharged from the aerosol discharge stem 14 into the lower portion 26 of aperture 15, and from there into thesmalllateral opening 27, must pass on its way to the eyecup 11 and the eye 17.
In addition, the intermediate chamber 28 is provided with two side vents 37 and 38-communicating directly with the atmosphere. In the construction illustrated these are two apertures extending from the aerosol-facing ing through the axis of the cylindrical portion 21 of the tube-like block 12, and are considerably larger in diameterthan the diameter of the lateral opening 27 through which the aerosol mist is introduced into the chambers 28 30. In the construction illustrated, this ratio is about 3 to l.
The result is that as the medicament in mist form passes, as a burst of'mist at relatively high velocity and relatively low temperature, from the aerosol discharge stem into the intermediate chamber 28, a substantial quantity of air is sucked through the side vents 37 and 38 into the intermediate chamber 28 and mixes with the mist in chambers 28 and 30, reducing its velocity and raising its temperature. Consequently, when the mist reaches the eye 17, it is not at a velocity or a temperature which will injure the eye.
To achieve this transition from a burst of high-velocity, low-temperature medicated mist from the aerosol cartridge that would be injurious to the eye if applieddirectly to the eye, to arnuch slower velocity mist having a higher temperature that does not injure the eye, this invention provides a device that is easy to use and simple in construction, and so can be made readily and inexpensively, such as by molding or casting a suitable plastic resin or other synthetic material.
It'is evident that the operation of this device is the same whether the device is used with the aerosol cartridge 13 positioned above the device, as shown in FIGURES l and 2, or is used in a position 180 degrees therefrom, in
which the aerosol cartridge 13 would be positioned be-,
low the device.
What is claimed is: V A device for administering to the eye a brus't of medicament-containing mist discharge from an aerosol container having an aerosol discharge stem, said device comprising: 7
(a) an eyecup; and Y (b) a tube-like block connected to the eyecup and adapted to be interposed between the aerosol diseyecup; said block comprischarge stem and the ing: 7
(i) a substantially solid end portion having a shouldered aperture therein for receiving the discharge stem of the aersol container, the axis of the aerosol stem-receiving aperture being substantially perpendicular to and intersecting the axis of the tube-like block with the end of such stem adapted to abut againstthe shoulder of such aperture, said shoulder being located in a position prior to the intersectiontof said axes, said aperture extending a short distance past said shoulder; 7 (ii) a substantially cylindrical, largely hollow portion forming a main chamber, with one end of said chamber communicating with the opening in the apex of the eyecup; (iii) an intermediate portion intergal with said solid end portion and forming an intermediate chamber communicating atone end with the end of the main chamber remote from the ber elsewhere around the periphery of the block; and g 7 (iv) said intermediate portion having at least one aperture in the wall thereof extending from the side of the intermediate chamber to said flat exterior surface of the block to provide a side vent of minimum length and hence of maximum air capacity possible for its diameter,
whereupon, when the aerosol container is compressed relative to the block and the burst of medicament-containingmist is discharged at a relatively high velocity and at a relatively low temperature through the aerosol discharge stem into the intermediate chamber of the tube-like block, a substantial quantity of air is drawn into the intermediate chamber through the "Side vent thereof and is mixed with the aerosol mist in the intermediate chamber andjin the main chamber to increase the temperature of the mist and decrease its velocity so that, when the mixture reaches the eye through the eyecup, the resulting temperature and velocity of the mixture is not injurious to the eye.
References Cited by the Examiner UNITED STATES PATENTS 2,754,821 7/56 Burbig et al. 128-249 2,965,100 12/60 Bridge 128,208 3,001,524 9/61 Maison et a1. 128-72O8 X 3,012,555 12/61 Meshberg 128-408 X FOREIGN PATENTS 764,728 5/34 France.
RICHARD A. GAUDET, Primary Examiner.
JORDAN FRANKLIN, Examiner.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2754821 *||Jul 26, 1954||Jul 17, 1956||Arthur Dolan||Eye cup dispenser|
|US2965100 *||Oct 21, 1958||Dec 20, 1960||Sparklets Ltd||Applicators|
|US3001524 *||Mar 5, 1957||Sep 26, 1961||Riker Laboratories Inc||Aerosol dispensing apparatus|
|US3012555 *||May 18, 1959||Dec 12, 1961||Philip Meshberg||Dispensing package for material under pressure|
|FR764728A *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3392725 *||Jan 17, 1966||Jul 16, 1968||Charles A. Behney||Veterinary ophthalmic applicator|
|US3770170 *||Aug 28, 1972||Nov 6, 1973||Vca Corp||Confining hand-held dispenser cap|
|US4551139 *||Feb 8, 1982||Nov 5, 1985||Marion Laboratories, Inc.||Method and apparatus for burn wound treatment|
|US4579858 *||Jan 11, 1984||Apr 1, 1986||Aktiebolaget Leo||Smoking substitutes for nasal administration-I|
|US4798599 *||Jan 3, 1984||Jan 17, 1989||George Thomas||Eye washing method and apparatus|
|US4834728 *||Dec 28, 1987||May 30, 1989||Mckenna Bill||Eye drop dispenser apparatus|
|US4846168 *||Dec 1, 1987||Jul 11, 1989||Mect Corporation||Inhaler|
|US5008963 *||Jul 3, 1989||Apr 23, 1991||Haws Company||Emergency wash station|
|US5037001 *||Jan 7, 1991||Aug 6, 1991||Fred Presant||Means and method for metered single-drop dispensing of water solutions from aerosol container|
|US5163929 *||Oct 22, 1990||Nov 17, 1992||O.P.T.I.C., Inc.||Ocular vial|
|US5346132 *||Nov 12, 1992||Sep 13, 1994||Gary S. Hahn||Mist generator|
|US5893515 *||Apr 1, 1994||Apr 13, 1999||Gary S. Hahn||Mist generator|
|US6336917 *||Feb 4, 1998||Jan 8, 2002||Nulli Secundus, Inc.||Ocular inspection and eye mist apparatus|
|US6423040 *||Jun 2, 1998||Jul 23, 2002||Pharmacia Ab||Eye fluid applicator|
|US7063687||May 21, 2002||Jun 20, 2006||Agouron Pharmaceuticals , Inc.||Eye fluid applicator|
|US7883031||May 20, 2004||Feb 8, 2011||James F. Collins, Jr.||Ophthalmic drug delivery system|
|US8012136||Sep 6, 2011||Optimyst Systems, Inc.||Ophthalmic fluid delivery device and method of operation|
|US8343117 *||Jan 19, 2010||Jan 1, 2013||Michael Rosado||Combination cigarette lighter and eye drop device|
|US8545463||Jan 26, 2007||Oct 1, 2013||Optimyst Systems Inc.||Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device|
|US8684980||Jul 15, 2011||Apr 1, 2014||Corinthian Ophthalmic, Inc.||Drop generating device|
|US8733935||Jul 15, 2011||May 27, 2014||Corinthian Ophthalmic, Inc.||Method and system for performing remote treatment and monitoring|
|US8936021||Oct 6, 2008||Jan 20, 2015||Optimyst Systems, Inc.||Ophthalmic fluid delivery system|
|US9087145||Jul 15, 2011||Jul 21, 2015||Eyenovia, Inc.||Ophthalmic drug delivery|
|US9186690 *||Feb 1, 2011||Nov 17, 2015||Bausch & Lomb Incorporated||Ergonomic hand-operable fluid-dispensing device|
|US20020193757 *||May 21, 2002||Dec 19, 2002||Maria Benktzon||Eye fluid applicator|
|US20040256487 *||May 20, 2004||Dec 23, 2004||Collins James F.||Ophthalmic drug delivery system|
|US20070119968 *||Jan 26, 2007||May 31, 2007||Optimyst Systems Inc.||Ophthalmic fluid delivery device and method of operation|
|US20070119969 *||Jan 26, 2007||May 31, 2007||Optimyst Systems Inc.||Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device|
|US20090043269 *||Jan 20, 2006||Feb 12, 2009||Skou Mikkel J R||Apparatus for dispension of liquid|
|US20090149829 *||Oct 6, 2008||Jun 11, 2009||Collins Jr James F||Ophthalmic fluid delivery system|
|US20090182291 *||May 10, 2007||Jul 16, 2009||Eran Eilat||Eye medicament dispenser|
|US20090270821 *||Jun 27, 2007||Oct 29, 2009||Alcan Global Pharmaceutical Packaging , Inc.||Angled ophthalmic dropper tip|
|US20120197219 *||Aug 2, 2012||Scanlon Christopher M||Ergonomic Hand-Operable Fluid-Dispensing Device|
|USD738508 *||Jun 11, 2013||Sep 8, 2015||Thomas Nichols||Personal care vaporizer device for the eye area|
|WO2002072169A2 *||Mar 8, 2002||Sep 19, 2002||Antares Pharma Inc||Ocular drug delivery nebulizer|
|U.S. Classification||128/200.23, D24/110, 222/518, D24/113, 222/402.1, D24/120, 604/301, 604/298|
|International Classification||A61H35/00, A61H35/02|