|Publication number||US3173876 A|
|Publication date||Mar 16, 1965|
|Filing date||May 27, 1960|
|Priority date||May 27, 1960|
|Publication number||US 3173876 A, US 3173876A, US-A-3173876, US3173876 A, US3173876A|
|Inventors||Zobrist John C|
|Original Assignee||Zobrist John C|
|Export Citation||BiBTeX, EndNote, RefMan|
|Referenced by (105), Classifications (14) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Cleaning methods and compositions
US 3173876 A
United States Patent 3,173,876 CLEANING METHODS AND COMPOSITIONS John C. Zobl'ist, 1012 Bridge Road, Charleston 4, W. Ya. No Drawing. Filed May 27, 1960, Ser. No. 32,088 4 Claims. (Cl. 252-137) This invention relates to a method for cleaning highly reflective surfaces, especially glass, tile, marble, porcelain and other vitreous materials, and to compositions for use in such a method. More specifically, the present invention relates to a method for cleaning highly reflective or polished vitreous surfaces by the use of aqueous compositions containing ethylenediamine. This is a continuation-in-part of my copending application Serial No. 803,066 filed March 31, 1959, for Method for Cleaning Superficial Material From a Surface, now abandoned.
There are today two general types of composition in general use for the cleaning of Window glass, mirrors, bathroom tile, polished marble, and other highly reflective surfaces. These compositions may be roughly classified as household ammonias, that is, solutions of am monium hydroxide, and soap and detergent compositions. Each composition has undeniably useful properties for the proposed use, but each is also attended by certain inherent disadvantages.
Household ammonia or solutions of ammonium hy droxide have generally favorable cleaning activity, but this composition is highly odorous and irritating. This is especially a factor where the ammonium hydroxide solu tion is to be employed indoors, as is usually the case. For example, the average housewife finds the use of such compositions for window cleaning very unpleasant and the vapors may even result in irritation to the eyes and nose of the user to the point of causing headache and nausea in hypersensitive individuals.
Because of the disadvantages of the ammonium hydroxide cleaners, a number of soap and detergent compositions have come into use which have no noticeable or unpleasant odor. However, from the standpoint of cleaning action, such soap or detergent compositions leave much to be desired. While soap and detergent solutions are generally effective to remove superficial soil from the surface to be cleaned, they invariably result in a streaked finish. This is occasioned by the fact that a thin film of the detergent material is generally left on the surface and appears in the form of visible streaks even though the surface has been wiped with a cloth following the application of the cleaner. It may be pointed out that the active ingredients in most of these soap and detergent type of cleaners are somewhat hygroscopic and have low vapor pressures. These materials do not volatize readily after application and they draw from the air small amounts of moisture which result in very apparent streaking on the cleaned surface. Obviously, where the surface being cleaned is window glass, mirror glass, ceramic tiles or the like, the presence of streaking after cleaning is quite undesirable and actually defeats the purpose of the cleaning operation.
According to the present invention, there has been developed at method for cleaning highly reflective surfaces, especially vitreous surfaces such as glass, porcelain, tile and the like, which overcomes the noted disadvantages inherent in the use of other compositions known for such use.
It is, therefore, a primary object of this invention to provide a method for cleaning highly reflective surfaces which is not attended by the presence of strong or unpleasant odors and which does not result in streaking on the surface to be cleaned or retention by the surface of a residual film of cleaner.
A further object of the invention is the cleaning of highly reflective surfaces by means for aqueous composi- 3,173,876 Patented Mar. 16, 1965 tions which effectively remove from the surface all common varieties of soil, leave no streaks or residual film and are capable of use without unpleasant side effects, such as odor, skin irritation or the like.
Another object of the present invention is to provide compositions for the cleaning of highly reflective surfaces, especially glass, tile, marble, and like vitreous materials, which are capable of effectively removing greases, oils, gums and the other bases for the more common types of soil.
An additional object of the present invention is to provide cleaning compositions for use on the surface of glass, tile, and other vitreous or highly reflective surfaces which may be applied either by transfer from a saturated applicator or by spraying, which effectively clean and visibly brighten the treated surfaces and which may be employed without unpleasant odor, irritation or other undesirable side effects.
Broadly, the present invention comprises treating highly reflective surfaces with an aqueous solution of ethylenediamine, the ethylenediamine being present in amounts of from 0.2 to 12%. It has been found that such solutions do not irritate, have no unpleasant odor, and will effectively clean highly polished or reflective surfaces Without streaking or depositing a residual film.
The remarkable cleaning properties of ethylcnediamine solutions may be attributed to the powerful solvent action which they have on greases and oils which are a principal component of many types of soil and which account in large part for residual streaking when treated with other cleaners. Elhylcnediamine solutions also solubilize gums and saponify many fatty materials present in oils, converting them to highly soluble soaps which enhance the cleaning properties.
It should also be noted that ethylenediamine has a vapor pressure that approaches that of water and, therefore, when applied in aqueous solution the ethylenediamine evaporates rapidly when compared to other solutions of soaps and detergents. This property accounts in some measure for the nonstreaking cleaning properties of aqueous cthylenediarnine solutions.
It has also been found to be highly advantageous to introduce into the composition small but significant amounts, generally about 1.0% to 5.0% by volume, of an enhancing material, such as sodium borate, trisodium phosphate, sodium hexametaphosphate, sodium tripolyphosphate, and the like.
It has generally been found desirable to prepare solutions of the present type for commercial use wherein the concentration of cthylenediamine is between 3.0% and 10.0% by weight of the solution. In such formulation, the enhancing substance will generally be present in amounts of from 1.0% to 5.0%. Thus, if the accumulation of soil is especially heavy and a fairly concentrated cleaning solution is called for, the compositions may be used directly without further dilution. Also, for light cleaning jobs, the more concentrated solutions may be further diluted with water to a point where the concen' tration of ethylenediamine is from about 0.2% to 1.0%. The cleaning activity of the composition is still quite effective even at such a low concentration of the ethylenediamine.
The compositions of the present invention lend themselves to a variety of types of application. According to more conventional practice, they maybe used to saturate an applicator, such as as absorbent cloth, and then are wiped upon the surface to be cleaned. After the elapse of a short period of time, generally only a few seconds, during which the ethylenediamine penetrates, dissolves and loosens soil, the surface may then be wiped clean with a dry cloth without leaving any streaks or residual film on the surface.
By a slight modification the aqueous solutions of ethylcnediamine may also be advantageously employed in spray application cleaning procedure by the addition of alcohol to promote more rapid drying. For example, from 5.0% to 35.0% ethanol or isopropanol may be combined with an aqueous solution of ethylenediamine, with or without an enhancer, to produce a remarkably effective cleaner for use in spray application on glass, tile, marble or other highly reflective surfaces.
In order to better understand the present invention, it may be well to consider the following specific examples of preferred methods and compositions within the scope of the present invention:
Example 1 [All formulae are expressed in percent by weight] Ethylcnediaminc 0.5 Water 99.5 Example 2 Ethylenediarnine 0.2 Sodium borate 0.2 \Vater 99.6
The cleaning compositions set forth in the above formulations are very useful for the cleaning of window panes and mirrors. T he concentration of ethylenediamine is quite sufficient to remove ordinary surface S011 and after application from a cloth or other absorbent applicator the composition and entrained or dissolved soil may be completely removed from the surface by butting with a dry cloth without residual streaking.
Example 3 Ethylenediamine 7.0 Sodium phosphate 3.5 Water 89.5
The composition of Formula No. 3 is quite satisfactory for heavy cleaning jobs and it is a composition of this approximate formula which is considered well suited for bottling and commercial sale. The purchaser may use the composition in full strength or may dilute portions of the composition with water to obtain a reduced concentration of the ethylenediamine better suited to the particular need.
Example 4 Ethylenecliamine 0.2 Trisodium phosphate 0.2 Isopropanol 5.0 Water 94.6
A composition of the above formula is especially suited to spray application to the surface to be cleaned. For example, such a composition might be introduced into one of the common, manually operated spray or atomizer bottles in wide use for applying cleaning materials to window glass.
Other examples of compositions within the scope of the present invention and for use in methods for cleaning polished and reflective surfaces include the following:
Compositions of the above Formulae 5, 6 and 7 are suited for wipoon, wipe-oil" application techniques.
Example 8 Ethylenediamine 1.0 Sodium borate 1.0 Ethanol 10.0 Water 88.0
Example 9 Ethylenediamine 0.5 lsopropyl alcohol 20.0 Water 79.5
Example 10 Ethylenediamine 1.0 Trisodiun'i phosphate 1.0 Methyl alcohol 31.0 \Nater 63.0
Compositions according to the Formulae 8, 9 and 10 are especially useful for spray-on, wipe-off methods of application.
All of the foregoing compositions have been found to give excellent results and particular utility in the cleaning of polished vitreous surfaces, including ceramic tile, porcelain, window glass and the like.
According to the present invention, therefore, highly polished or reflective surfaces, such as those of glass, tile, marble and other like materials, may be efficiently and thoroughly cleaned by application of compositions of the type herein described, either by a wipe-on, wipe-off" mode of application or by a spray-on, wipe-off technique, and this is accomplished without odor, irritation or other un desirable side effects and without streaking or retention of: residual film on the cleaned surface.
It will be apparent to those skilled in the art that various modifications, changes, and substitutions may be made in the method and compositions comprising the present invention without materially departing from the scope of the invention and, therefore, the matter contained herein is intended to be illustrative rather than limitative.
What is claimed is:
1. The method for cleaning reflective vitreous surfaces which comprises applying to said surfaces a liquid composition consisting essentially of from 0.2% to 12.0% by Weight of ethylenediamine dissolved in water, and then removing said composition from said surface.
2. The method for cleaning reflective vitreous surfaces which comprises wiping onto said surfaces an aqueous solution consisting essentially of from 0.2% to 12.0% by weight ethylenediamine and from 0.2% to about 5.0% by weight of a material selected from the group consisting of sodium horate, trisodium phosphate, sodium hexametaphosphate and sodium tripolyphosphate, and then wiping said solution from said surfaces.
3. The method for cleaning reflective vitreous surfaces which comprises spraying onto said surfaces an aqueous solution consisting essentially of from 0.2% to 12.0% by weight cthylcnediarnine, and from 5.0% to 35.0% by weight of an alcohol selected from the group consisting of methanol, ethanol, propanol and isopropanol and then wiping said solution from said surfaces.
4. The method of claim 1 where said surface is glass.
References Cited by the Examiner UNITED STATES PATENTS 2,471,645 5/49 Morris et al. 252--l37 2,509,440 5/50 Little 252l37 2,524,380 10/50 Flaxman 252137 2,540,003 l/Sl McCoy 252l53 2,731,420 l/56 Sylvester 252l37 OTHER REFERENCES New Aliphatic Amines, article in Ind. and Eng. Chem., August 1935, vol. 27, No. 8, pages 867-871, by Wilson.
Surface Active Agents, by Schwartz et al., 1949, Interscience Pub, Inc, page 377.
JULIUS GREENWALD, Primary Examiner.
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3321407 *||Jul 2, 1964||May 23, 1967||Myer Rosenfeld||Ethylenediamine-tetrahydrofuran paint-stripping compositions|
|US3322677 *||Jul 2, 1964||May 30, 1967||Myer Rosenfeld||Ethylenediamine-anisole paint-stripping compositions|
|US3324037 *||Jul 2, 1964||Jun 6, 1967||Myer Rosenfeld||Thixotropic ethylenediamine-based paint strippers|
|US3324039 *||Jul 2, 1964||Jun 6, 1967||Myer Rosenfeld||Ethylenediamine-n, n-dimethylformamide paint-stripping compositions|
|US3637508 *||Mar 6, 1970||Jan 25, 1972||Daniel J Brogan||Process and composition for dissolving copper oxide|
|US4152306 *||Apr 11, 1978||May 1, 1979||LDMJ Limited||Water, alkali metal phosphate, sodium alkylbenzenesulfonate, alkoxyalkanol|
|US4213873 *||Mar 10, 1978||Jul 22, 1980||Leisure Products Corporation||Water based window, glass and chrome cleaner composition|
|US4556509 *||Oct 9, 1984||Dec 3, 1985||Colgate-Palmolive Company||Light duty detergents containing an organic diamine diacid salt|
|US4693886 *||Apr 22, 1985||Sep 15, 1987||Alza Corporation||Osmotic device with inert core|
|US4969884 *||Dec 28, 1988||Nov 13, 1990||Alza Corporation||Osmotically driven syringe|
|US5030216 *||Dec 15, 1989||Jul 9, 1991||Alza Corporation||Osmotically driven syringe|
|US5035897 *||Sep 5, 1989||Jul 30, 1991||Alza Corporation||Dosage form for delivering soluble or insoluble drugs|
|US5126142 *||Jan 11, 1991||Jun 30, 1992||Alza Corporation||Dispenser comprising ionophore|
|US5151093 *||Oct 29, 1990||Sep 29, 1992||Alza Corporation||Osmotically driven syringe with programmable agent delivery|
|US5200194 *||Dec 18, 1991||Apr 6, 1993||Alza Corporation||Oral osmotic device|
|US5236689 *||Apr 24, 1992||Aug 17, 1993||Alza Corporation||Dispenser for discrete drug-containing units in predetermined pattern or profile; for use in fluid environment|
|US5240713 *||Sep 27, 1991||Aug 31, 1993||Alza Corporation||Dual rate agent delivery device|
|US5252245 *||Feb 7, 1992||Oct 12, 1993||The Clorox Company||Reduced residue hard surface cleaner|
|US5273752 *||Sep 19, 1991||Dec 28, 1993||Alza Corporation||Controlled release dispenser comprising beneficial agent|
|US5312389 *||Apr 3, 1992||May 17, 1994||Felix Theeuwes||Osmotically driven syringe with programmable agent delivery|
|US5340590 *||Jul 8, 1993||Aug 23, 1994||Alza Corporation||Delivery system with bilayer osmotic engine|
|US5391381 *||May 11, 1993||Feb 21, 1995||Alza Corporation||Dispenser capable of delivering plurality of drug units|
|US5437807 *||Oct 8, 1993||Aug 1, 1995||The Clorox Company||Reduced residue hard surface cleaner|
|US5468423 *||Oct 8, 1993||Nov 21, 1995||The Clorox Company||Reduced residue hard surface cleaner|
|US5474785 *||Jul 15, 1993||Dec 12, 1995||Alza Corporation||Compartment containing viscosity and density increasing beneficial agent|
|US5523024 *||Aug 23, 1995||Jun 4, 1996||The Clorox Company||Aqueous cleaning solution comprising alkanol, alkylene glycol ether, trialkylamine oxide and ammonium carbamate or alkaline earth carbamates; antisoilants, nonsmearing|
|US5532003 *||Jan 18, 1994||Jul 2, 1996||Alza Corporation||Pentoxifylline therapy|
|US5540665 *||Jan 31, 1994||Jul 30, 1996||Alza Corporation||Gas driven dispensing device and gas generating engine therefor|
|US5603954 *||May 24, 1995||Feb 18, 1997||Alza Corporation||Pentoxifylline therapy and method of use|
|US5707663 *||May 16, 1995||Jan 13, 1998||Alza Corporation||Sustained antiepileptic therapy|
|US5817615 *||Jun 3, 1996||Oct 6, 1998||The Clorox Company||Reduced residue hard surface cleaner|
|US5851981 *||Aug 22, 1997||Dec 22, 1998||The Clorox Company||Reduced residue hard surface cleaner|
|US5980943 *||Oct 21, 1997||Nov 9, 1999||Alza Corporation||A time release dosage form comprising a semipermeable wall in contact with a therapeutic drug granules coated with polyoxyalkylene glycol|
|US5990065 *||Dec 20, 1996||Nov 23, 1999||The Procter & Gamble Company||Dishwashing detergent compositions containing organic diamines for improved grease cleaning, sudsing, low temperature stability and dissolution|
|US6069122 *||Dec 12, 1997||May 30, 2000||The Procter & Gamble Company||Hand dishwashing detergent comprising a low molecular weight diamine having a pk1 and pk2 in the range of 8.4 to 11.5; and a mixture of anionic and nonionic surfactants; where the ph is from about 8.0 to 12|
|US6174547||Jul 14, 1999||Jan 16, 2001||Alza Corporation||Comprising a drug formulation that self-emulsifies to enhance the solubility, the dissolution, and the bioavailability of the drug|
|US6210712||Dec 4, 1998||Apr 3, 2001||Alza Corporation||First or interior coat consisting of ethylcellulose and hydroxypropyl cellulose shielded by a second or exterior coat consisting of poly(cellulose acylate) from the environment of the gastrointestinal tract.|
|US6245357||Feb 12, 1999||Jun 12, 2001||Alza Corporation||Extended release dosage form|
|US6287598||May 28, 1993||Sep 11, 2001||Alza Corporation||Method for providing sustained antiepileptic therapy|
|US6342249||Dec 22, 1999||Jan 29, 2002||Alza Corporation||Certain absorbent materials such as porous calcium hydrogen phosphate powders are used to deliver drugs in a liquid state|
|US6440457||May 27, 1993||Aug 27, 2002||Alza Corporation||Administering venlafaxine antidepressant time-release agent; sustained release|
|US6510561||Oct 20, 1999||Jan 28, 2003||Reckitt Benckiser (Uk) Limited||Dispensing device|
|US6514530||Aug 5, 1998||Feb 4, 2003||Alza Corporation||For oral administration, comprising a semipermeable membrane surrounding a therapeutic composition comprising a dose of drug; dosage form imbibes fluid through the membrane in response to concentration gradient; sustained release|
|US6551613||Jul 14, 1999||Apr 22, 2003||Alza Corporation||Dosage form comprising therapeutic formulation|
|US6589926||Feb 6, 1999||Jul 8, 2003||Procter & Gamble Company||Dishwashing detergent compositions containing organic diamines|
|US6596314||Dec 14, 2001||Jul 22, 2003||Alza Corporation||Controlled release liquid active agent formulation dosage forms|
|US6706282||Nov 1, 1999||Mar 16, 2004||Evangeline Cruz||Sustained release osmotic dosage form without delayed release coating adapted for once a day administration as suspension or slurry; such as nefazodone|
|US6727212||Nov 6, 1998||Apr 27, 2004||The Procter & Gamble Company||Contacting hard surface for a time sufficient to soften soil with composition comprising high ph soil softening additive|
|US6855334||Nov 27, 2001||Feb 15, 2005||Alta Corporation||Controlled delivery of active agents|
|US7129248||Mar 30, 2005||Oct 31, 2006||Euro-Celtique, S.A.||comprising hydrogenating with a hydrogen donor and a catalyst under reflux|
|US7172767||Oct 27, 2003||Feb 6, 2007||Purdue Pharma L.P.||Opioid agonist / antagonist combinations|
|US7259186||Jun 30, 2004||Aug 21, 2007||Abbott Laboratories||Salts of fenofibric acid and pharmaceutical formulations thereof|
|US7384653||Sep 23, 2004||Jun 10, 2008||Purdue Pharma L.P.||Oral dosage form comprising a therapeutic agent and an adverse-effect agent|
|US7419686||Dec 26, 2006||Sep 2, 2008||Purdue Pharma L.P.||For preventing oral abuse of an oral opioid formulation; provides a negative, "aversive" experience when a large amount of the opioid, e.g., about 2-3 times the usually prescribed dose, is taken by or administered to a physically dependent subject|
|US7674798||Jan 16, 2007||Mar 9, 2010||Purdue Pharma L.P.||Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone|
|US7674799||Jan 16, 2007||Mar 9, 2010||Purdue Pharma L.P.||Oral dosage forms; FDA Orange book listed patent for oxycodone hydrochloride, known as oxycontin tradename|
|US7674800||Mar 29, 2007||Mar 9, 2010||Purdue Pharma L.P.||Process of salt formation and by-product inhibition; FDA Orange Book listed patent for tradename Oxycontin|
|US7683072||Jan 16, 2007||Mar 23, 2010||Purdue Pharma L.P.||Oxycontin tradename; purity|
|US7713550||Jun 15, 2004||May 11, 2010||Andrx Corporation||Controlled release sodium valproate formulation|
|US7736668||Jan 28, 2003||Jun 15, 2010||Janssen Pharmaceutica Nv||A delayed delivery drug dose to a fluid environment consists of a dose of drug, a second formulation with imbibes fluid and expands, a wall that confines both and permeable to the passage of fluid, a subcoat of hydroxyalkyl cellulose|
|US7749542||Jul 28, 2008||Jul 6, 2010||Purdue Pharma Lp||For preventing oral abuse of an oral opioid formulation; provides a negative, "aversive" experience when a large amount of the opioid, e.g., about 2-3 times the usually prescribed dose, is taken by or administered to a physically dependent subject|
|US7943173||Jul 18, 2002||May 17, 2011||Purdue Pharma L.P.||Pharmaceutical combinations of oxycodone and naloxone|
|US8071073||Nov 22, 2005||Dec 6, 2011||Meda Pharmaceuticals Inc.||Compositions comprising azelastine and methods of use thereof|
|US8084059||Sep 15, 2006||Dec 27, 2011||Alza Corporation||Antidepressant dosage form|
|US8105631||May 24, 2010||Jan 31, 2012||Purdue Pharma L.P.||Opioid agonist/antagonist combinations|
|US8226979||Apr 11, 2011||Jul 24, 2012||Alza Corporation||Drug coating providing high drug loading and methods for providing the same|
|US8246986||Sep 23, 2004||Aug 21, 2012||Alza Corporation||Drug coating providing high drug loading|
|US8313770||May 30, 2008||Nov 20, 2012||Neos Therapeutics, Lp||Modifying drug release in suspensions of ionic resin systems|
|US8318210||Feb 28, 2005||Nov 27, 2012||Neos Therapeutics, Lp||Compositions and methods of making sustained release liquid formulations|
|US8337888||Jan 12, 2012||Dec 25, 2012||Purdue Pharma L.P.||Pharmaceutical formulation containing gelling agent|
|US8389007||Oct 30, 2008||Mar 5, 2013||Purdue Pharma L.P.||Pharmaceutical composition containing gelling agent|
|US8465774||Feb 13, 2006||Jun 18, 2013||Purdue Pharma L.P.||Sequestered antagonist formulations|
|US8518919||Nov 10, 2011||Aug 27, 2013||Meda Pharmaceuticals Inc.||Compositions comprising azelastine and methods of use thereof|
|US8518925||Jun 8, 2005||Aug 27, 2013||Euro-Celtique S.A.||Opioids for the treatment of the chronic obstructive pulmonary disease (COPD)|
|US8524277||Feb 9, 2007||Sep 3, 2013||Alza Corporation||Extended release dosage form|
|US8524749||Jan 16, 2008||Sep 3, 2013||Alza Corporation||Administering a dosage form of 6-20 mg of tizanidine; plasma drug concentration substantially ascends over a period of 8 hours following administration|
|US8529948||May 30, 2013||Sep 10, 2013||Purdue Pharma L.P.||Pharmaceutical formulation containing gelling agent|
|US8541026||Apr 20, 2007||Sep 24, 2013||Abbvie Inc.||Sustained release formulations of opioid and nonopioid analgesics|
|US8609683||May 30, 2013||Dec 17, 2013||Purdue Pharma L.P.||Pharmaceutical formulation containing gelling agent|
|US8673355||Dec 27, 2011||Mar 18, 2014||Purdue Pharma L.P.||Opioid agonist/antagonist combinations|
|US8758816||Sep 29, 2009||Jun 24, 2014||Meda Pharmaceuticals Inc.||Compositions comprising azelastine and methods of use thereof|
|US8758825||May 22, 2013||Jun 24, 2014||Purdue Pharma L.P.||Sequestered antagonist formulations|
|EP1652516A2||Oct 26, 1999||May 3, 2006||ALZA Corporation||Osmotic controlled delivery of active agents|
|EP1905435A2||Mar 11, 2004||Apr 2, 2008||Euro-Celtique S.A.||Titration dosing regimen for controlled release tramadol|
|EP1961421A1||Jun 8, 2005||Aug 27, 2008||Euro-Celtique S.A.||Opioids for the treatment of the chronic obstructive pulmonary disease (COPD)|
|EP2011485A2||May 2, 2002||Jan 7, 2009||Euro-Celtique S.A.||Once-a-day oxycodone formulations|
|EP2074992A1||Apr 7, 2006||Jul 1, 2009||Abbott Laboratories||Pharmaceutical formulations|
|EP2255808A2||Jun 1, 2005||Dec 1, 2010||Euro-Celtique S.A.||Opioids for the treatment of the restlessness of the lower limbs|
|EP2298303A1||Sep 9, 2004||Mar 23, 2011||Euro-Celtique S.A.||Pharmaceutical combinations of hydrocodone and naltrexone|
|EP2305683A1||Mar 30, 2005||Apr 6, 2011||Euro-Celtique S.A.||Pharmaceutical dosage form comprising oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone|
|EP2311839A1||Mar 30, 2005||Apr 20, 2011||Euro-Celtique S.A.||Oxycodone hydrochloride composition having less than 25 ppm 14-hydroxycodeinone|
|EP2314589A1||Mar 30, 2005||Apr 27, 2011||Euro-Celtique S.A.||Process for preparing oxycodone hydrochloride having less than 25ppm 14-hydroxycodeinone|
|EP2316837A1||Mar 30, 2005||May 4, 2011||Euro-Celtique S.A.||Process for preparing oxycodone hydrochloride having less than 25ppm 14-hydroxycodeinone|
|EP2319846A1||Mar 30, 2005||May 11, 2011||Euro-Celtique S.A.||Process for preparing oxycodone hydrochloride having less than 25ppm 14-hydroxycodeinone|
|EP2377557A2||Nov 22, 2005||Oct 19, 2011||MedPointe Healthcare Inc.||Compositions comprising azelastine and methods of use thereof|
|EP2426132A1||Mar 30, 2005||Mar 7, 2012||Euro-Celtique S.A.||Process for preparing 14-hydroxycodeinone from thebaine|
|EP2486942A1||Nov 22, 2005||Aug 15, 2012||Meda Pharmaceuticals Inc.||Compositions comprising azelastine and methods of use thereof|
|EP2522365A1||Nov 22, 2005||Nov 14, 2012||Meda Pharmaceuticals Inc.||Compositions comprising azelastine and methods of use thereof|
|WO2000023663A1||Oct 20, 1999||Apr 27, 2000||Hammond Geoffrey Robert||Dispensing device|
|WO2000062764A1||Apr 18, 2000||Oct 26, 2000||Alayne Yates||Gum pad for delivery of medication to mucosal tissues|
|WO2006058022A1||Nov 22, 2005||Jun 1, 2006||Medpointe Healthcare Inc||Compositions comprising azelastine and methods of use thereof|
|WO2008084698A1||Dec 26, 2007||Jul 17, 2008||Astellas Pharma Inc||Tacrolimus sustained release pharmaceutical composition|
|WO2011122524A1||Mar 28, 2011||Oct 6, 2011||Astellas Pharma Inc.||Controlled release pharmaceutical composition|
|WO2014013311A1||Jul 15, 2013||Jan 23, 2014||Rhodes Technologies||Process for improved opioid synthesis|
|WO2014013313A1||Jul 15, 2013||Jan 23, 2014||Rhodes Technologies||Process for improved opioid synthesis|
| || |
|U.S. Classification||134/42, 510/239, 510/182, 510/420, 510/181, 510/240, 510/499, 510/433, 510/238, 510/108|
|International Classification||C11D3/26, C11D3/30|