|Publication number||US3183908 A|
|Publication date||May 18, 1965|
|Filing date||Sep 18, 1961|
|Priority date||Sep 18, 1961|
|Publication number||US 3183908 A, US 3183908A, US-A-3183908, US3183908 A, US3183908A|
|Inventors||Samuel C Collins, Ernest M Barsamian|
|Original Assignee||Samuel C Collins, Ernest M Barsamian|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (8), Referenced by (36), Classifications (11)|
|External Links: USPTO, USPTO Assignment, Espacenet|
May 18, 1965 s. C. coLLlNs ETAL. 3,183,908
PUMP OXYGENATOR SYSTEM 3 Sheets-Sheet l Filed Sept. 1S. 1961 May 18, 1965 s. c. COLLINS ETAI. 3,183,908
PUMP OXYGENATOR SYSTEM 3 Sheets-Sheet 2 Filed Sept. 18, 1961 .'.El Er INVENTOR. Sande-L C. Cou/Ns ERA/fsf M.
May 18, 1965 s. c. COLLINS ETA.. 3,183,908
PUMP OXYGENATOR SYSTEM Filed Sept. 18, 1961 3 Sheets-Sheet .'5
United States Patent() 3,183,903 PUMP OXYGENATR SYSTEM Samuel C. Collins, Belmont, and Ernest M. Barsamian,
West Roxbury, Mass., assignors, by mesne assignments,
to the United States of America as represented by the Secretary of the Navy Filed Sept. 18, 1961, Ser. No. 139,016 16 Claims. (Cl. 12S- 214) The present invention relates generally to apparatus for and methods of reproducing the functions of the cardiac and pulmonary organs of a human or animal and, more particularly, to a pump-oxygenator for assuming these vital functions -on a temporary basis, such as during openheart surgery.
In the treatment of certain human ailments, it is oftentimes desirable to relieve the patients heart and lungs from performing their pumping and oxygenating functions so that surgical repairs t-o these organs may be performed while vthey `are relatively inactive. Mechanical subs-titutes for these organs usually take blood from the patients venous system and first disperse it over a large area in an atmosphere of pure or nearly pure oxygen. After the blood absorbs oxygen in this environment, it is forced by means of a pressure pump into the arterial system of the patient. To be life-sustaining, this process must be continuous and, hence, the pump-oxygenator or heart-lung machine, as it is sometimes called, must process unfailingly a steady stream of blood.
While it is possible to sustain life forv hours by means of a pump-oxygenator, even when the heart is completely bypassed, existing machines have certain shortcomings which have so far limited their success. For example, the red corpuscles in blood are often destroyed at a fairly high 'rate while these machines `are in use. Furthermore, a relatively large amount'lof blood is generally required to lill the pump-oxygenator system. And since this amount cannot be provided by the patient, it must be supplied by donors. Moreover, after each use the 4apparatus must be disassembled, thoroughly cleaned, `and the parts contaminated by blood sterilized and carefully stored for future use. When next needed, these parts, of course, must be reassembled with elaborate precautions taken to insure their sterility.
It is accordingly a primary object of the present invention to provide a pump-oxygenator of simple and reliable construction.
Another object of the present invention is to 4provide a puinp-oxygenator which requires a minimum amount of blood.
A still further object of the present invention is to provide a pump oxygenator wherein the oxygen both oxygenates the blood and furnishes all the motive power required by the apparatus.
A. still further object of ythe present invention is to provide a pump-oxygenator wherein damage to the blood and frothing ,are minimized.
A yet still further object of the present invention is to provide a pump-oxygenator which'derives its blood supply from the pa-tien-ts venous system and from blood seeping into the operating area.
A still further object of the present invention is to provide a pump-oxygenator having -a suction pump which functions with a minimum amount of turbulence whereby little damage or destruction of the red cells of the blood occurs. l
A yet still lfurther object of the pre-sent invention is t Iprovide a pump-oxygenator wherein compressed oxygen first opera'tes the engine driving the oxygenating apparatus and thereafter oxygenates the blood.
A yet still `further object of the present invention is to provide a pumpeoxygenatorrwherein the pump mechap lli Patented May 18, 1965 ICC nism 'has a decreasing competence with a decreasing level of blood in the system.
A yet still further object of the present invention is to provide a syphon-type coronary sucker for use in a pump-oxygenating system to augment the blood available from the patients venous system.
A yet still further object of the present invention is to provide a pump-oxygenator wherein the performance of the pump mechanism is regulated by the level of blood in the oxygenator.
A yet still further object of the present invention is to provide a pumping mechanism for a pump-oxygenating system which can be readily sterilized.
A yet still further object of the present invention is to provide an oxygenator which can be autoclaved as a complete unit.
Other objects and many of the attendant advantages of this invention will be readily appreciated as the same becomes better understood by reference to the following detailed description when considered in connection with the accompanying drawings wherein:
FIG. 1 is a schematic diagram of the complete oxygenating system according to one embodiment of the invention;
FIG. 2 illustrates the structural details of one type of oxygenator;
FIG. 3 schematically depicts an alternative construction for the rotating component of the oxygenator;
FIG. 4 depicts the general construction of a pressure pump that can be employed in the system of FIG. l;
FIG. 5 illustrates a How-through type of pressure pump having similar use;
FIG. 6 illustrates one method of detachably mounting the oxygenator as a complete unit to the engine; and
FIG. 7 shows one general arrangement for automatically controlling the pressure pump in accordance with the level of blood within the oxygenator.
Briefly and in somewhat general terms, one embodiment of the present invention may be seen from anexamination of FIG. 1 to comprise a source of compressed oxygen 1, gas-operated engine 2 of the bellows type driven therefrom, cam-operated ball valve assembly 3 controlling this engine, oxygenator 4, its reservoir 5, pressure and suction pumps 6 and 7, surge chamber 8, and sucker 9 with its vacuum relief member 10.
Before discussing thestructural details of these devices and the manner in which they cooperate, it would be noted that all of the motive power for the above system is derived from the compressed oxygen and that the expended oxygen oxygenates the blood and acts as a vehicle for removing the carbon dioxide devolved therefrom.
Referring again to FIG. l, storage tank 1 contains oxygen at a pressure, for example, some ten pounds per square inch above atmospheric pressure and, when the valve controlling this tank is opened, a Istream of oxygen flows via line 11 to an entrance port 12 on the top of a first compartment 13 of ball valve assembly 3. For purposes of description, it will be assumed at this time that ball member 14 in this compartment is oit of its seat 15, permitting oxygen to flow out of main supply line 16 and via branch lines 17, 1S, 19 and 2t) tothe base of bellows 21 of engine 2 and to pumps 6 and 7. Coupled to bellows 21 via rod 22 is a crank assembly 23 which drives camshaft 24 when the above ow distends the bellows. Connected to this camshaft and rotatable therewith are gears 25, cams 26 and 27 and flywheel 28. Itis these cams acting through push rods 29 and 30 which control the opening and closing of compartments 13 and 31 of the ball valve assembly 3 by raising and lowering ball members 14 and 32 with respect to their seats 15 and 33. The design of these cams is such that one or the other of these compartments is always open. Consequently, under the conditions assumed, oxygen does not flow at this time from the lower portion of compartment 3 through aperture 34 in the common wall of these compartments and out into line 35 feeding oxygenator 4. It would be pointed out that the Weight of balls I4 and 31 is such that the oxygen pressure cannot influence their movement.
As crankshaft Zdrotates, a point in the engine cycle is reached whereat ball 14 descends to its seat 15, preventing the furtheriiow of oxygen into main supply line i6 and the apparatus fed therefrom. Ball 32 is above its seat 33 at this time, opening compartment 31, so that the oxygen stored in the various supply lines and in bellows 21 and pumps 6 and '7 now vents back through these lines, through aperture 34, compartment 31, into discharge line 35 and oxygenator 4 connected thereto. Because of the momentum of iiywheel 28, camshaft 24 continues to rotate after bellows ZI-has been fully distended, and the mechanical compression of this bellows which occurs at this time in the engine cycle assists the above discharge of oxygen. Engine 2. is thus made ready for the next stroke which occurs when ball valve assembly 3 returns to the condition initially described.
It will thus be seen that the cam-operated valve assembly 3 effectively sets up pulsations in the stream of oxy- 4,
gen emanating from storage tank 1. It is these pressure pulses which also operate pumps 6 and 7 in a manner which will be described hereinafter in greater detail. In one practical embodiment of this invention, pressure changes of one-half atmosphere occurred during the cycle, the pressure at the cylinder being ten pounds per square inch above atmospheric pressure.
The blood oxygenating apparatus, which is generally indicated by reference character 4, is housed within a stationary outer cylinder 36, closed at both ends by plates 3'7 and 38. This cylinder may be made of glass, for example, with the end plates of stainless steel. Disposed within this cylinder, as best shown in FIG. 2, is a second cylinder 39 of slightly smaller diameter. rIlhis latter cylinder rotates about a horizontal axis which is parallel to the axis of symmetry of cylinder 36 but displaced downwardly therefrom so that, while the outer surface of cylin- .der 39 almost touches the inner surface of cylinder 36 on the low side, a greater clearance exists between these same confronting surfaces on the top side. As illustrated in FIG. 2, two or more additional cylinders 40 and 4l of successively smaller diameter are nested Within cylinder 39 with the innermost cylinder of the pair resting on the larger Vcylinder and this cylinder, in turn, resting on the inner surface of cylinder 39. With this arrangement, whenever the 'latter cylinder rotates, the two freely supported cylinders also rotate because of friction and Vthe force of gravity.
Cylinder 39 is driven by crankshaft 24 and, more particularly, by gear secured thereto which meshes with gear 42 mounted on one end of drive shaft 43. The other end of this shaft terminates in a spline which mates with a slot cut in a stub shaft 44. A spider 46 having a central hub 45 is mounted on the other end of this stub shaft and, in the particular embodiment shown in FIG. 3, the inner surface of the spokes of this spider is notched at 47 to receiveone end of the rotating cylinder 39. A similar spider and stub shaft employed at the other end of the oxygenator completethe drive arrangement. VThe split drive shaft feature is employed to permit the oxygenator, that is, outer stationary cylinder 36 and the various cylinders housed therein, to be readily detached from the drive portion of the system; This greatly facilitates the sterilization process.
From What'has been described hereinbefore, it will be Y appreciated that oxygen is vented during each cycle of engine 2 via line 35 into the top portion of oxygenator 4 to oxygenate the blood and to carry off the carbon dioxide devolved therefrom. Throughout the operation of the oxygenating system, however, there is a continuous flow of venous'blood from the patient via line 45 into the oxygenating apparatus through a lower opening 49 formed d in outer cylinder 36. By positioning the patient above the oxygenator, a gravity ow is achieved.` Once the venous blood enters the oxygenator, it spreads over the lower surface of cylinder 36 and forms a relatively shallow pool 59 into which all three cylinders continuously dip as cylinder 39 rotates. 'Ihe blood is thus distributed in thin layers over both the inner and outer surfaces of these cylinders after a few rotations. This dispersal gives a large blood-surface-area-to-volume ratio and results in rapid oxygenation of the blood. In order to reduce the amount of`blood needed, both ends of innermost cylinder 4l. may be closed olf, as shown by plates 51 in FIG. 2. This avoids the necessity of filling the inner portion of the cylinder with blood and increases the level of blood in the oxygenator for a given volume.
Oxygenated blood leaves the oxygenator through opening 51 and flows via U-shaped tube 52 into reservoir 5 vented by tube 53. It will be recognized that by adjusting the relative height of this reservoir the level of blood within the oxygenator can be regulated. From the reservoir the blood iiows via line 54 and ball valve assembly 55 into pressure pump 6 which forces it into the arterial system of the patient. The ow of blood to and from this pump is regulated by a gravity controlled valve assembly 55 having balls 56 .and 57 which open and close cylinder 58. Lower ball 57 is designed with sufficient mass so that it lifts from its seat only when the level of blood in reservoir 5 or in the vertical portion of line 54 exceeds a predetermined safe level. This feature is a precautionary measure and prevents oxygen from being sucked from oxygenator 4 into pump 6 and being forced thereafter into the patients circulatory system. Normally, blood will flow into cylinder 58 and thence via line 59 into the top portion of pump 6. This pressure pump, in the simple conguration shown in FIG. 4, comprises a lower base member 60 Whose inner surface is concave, a closure plate 61 and a plastic or silicone rubber membrane 62 clamped at its edges between these two members by suitable bolts 63. Both base member 60 and cover plate 61 have passageways cut therethrough to allowv oxygen and blood to enter the pump on opposite sides of membrane 62.
It will be appreciated that when the oxygen is vented from the lower portion of pressure pump 6, blood ows into the top portion of the pump via line 59 and displaces membrane 62. downwardly fromrthe position shown in FIG. 4. Thereafter, when the next pressure pulse of oxygen appears, this'membrane is driven upwardly, forcing blood back through line 59 and into cylinder 58 to lift ball 56 from its seat and open a passageway to surge chamber 8. In one practical embodiment of the present invention, the oxygenator assembly was elevated above the pressure pump so as to maintain a liquid head of eight to twelve inches on this pump. Whenever the blood level fell below this, ball 57 remained closed and isolated the pump from the oxygenator.
In the modification shown in FIG. 1, pump 6 receives a charge of compressed oxygen and makes one stroke for each cycle of engine 4. Y It is often desirable to have only one stroke of the pump for several cycles of the engine, and this mode of operation can be readily realized by providing a second camshaft gear driven from shaft 24, the second camshaft turning at lower speed.
Surge chamber 8, which receives oxygenated blood from pressure pump 6, is included inthe system to smooth out the flow of blood into the pa-tients circulatory system. Without this chamber, blood would otherwise be forced xinto the patients system in the form of spiked pressure pulses of relatively high intensity. Such pulses would produce turbulence at the entry point which would damage the bloods red cells. In its simplest form, surge chamber'S can be .similar to pressure pumpV 6, employing a plastic membrane 63 held'between two metallic members having the same form as elements 60 and 61. This chamber requires Vno valves but preferably includes a screen lter 64 positioned-on the side of the diaphragm wetted by theblood. YThisgscreenV is formed with a central aperture'through which the blood passes into the upper portion of the chamber. Thereafter, the blood flows back through this screen before it enters discharge line 130 connected to the patient. On the other side of diaphragm 63 there is trapped a volume of oxygen, obtained from storage tank l via line 65, which serves as a cushion against the vigorous pulsing of pressure pump 6. The level of pressure in this part of the surge chamber is regulated by valves 66 and 67. Valves 68 and 69 provide means for purging oxygen from the system whenever the priming charge of blood is being added. It has been found that a pressure gaugereading the pressure of the oxygen cushion in the backside of the surge chamber provides an indication of the patients systolic and diastolic pressures during each cycle of the pump, and pressure gauge 7d is included in the system for this purpose. By carefully monitoring lthe performance of lthis gauge, the surgeon can anticipate the need of a blood transfusion.
Suction pump 7, in cooperation with sucker 9, collects blood from the operating area and adds it to that obtained from the patients venous system. This pump :is of low capacity and creates a limited vacuum in vessel 71 at the left side of FIG. 1. Connected to this vessel at a point intermediate its length is .a flexible tube 73, the other end of which (not shown) terminates in the blood pool formed by blood leaking from the patients circulatory system. When the oxygenator is operating, this chamber is kept at a significantly higher level than the venous blood line 48 so that the blood in this line cannot be sucked into the vacuum system. The degree of vacuum obtainable in vessel 7l is controlled by vacuum relief device 10 which consists of a tube 7d containing water or a salt solution 75 and equipped with an air pipe 76 which extends almost to the bottom of the above tube.
When an oxygen pressure pulse enters suction pump 7 via line 2t), bellows '77 of this pump is compressed and air is expelled therefrom via the upper valve 78 of ball valve assembly 79 to the atmosphere. Thereafter, when the oxygen in the system is vented, air is drawn into this bellows via line 8d from vessel 7i and from the air space above fluid 75 in relief device lit, the lower valve 8l of ball valve assembly 79 lifting at this time to permit the above flow to take place. After a few cycles of the pump, a negative pressure is thus established in vessel 9, and blood is drawn into this vessel from the operating area via tube 73. Once blood starts flowing between line 73 andvenous line 4?, it continues because of syphon-ing action, without regard to the pumping rate of suction pump 7, until the pool of leakage blood is depleted. Thereupon, air enters into the system and breaks the syphon. It would be appreciated that the height of fiuid 75 is significant because it establishes the point `at which air from the outside will be drawn via tube '76 into the system to limit the negative pressure in vessel 71. During the operation of .suction pump 7, there may be a two-phase flow in the suction line '73, slugs of blood and bubbles of air. However, the rate of pumping is so low that blood is not iniured by the air drawn into the system. This is in contrast with other types of coronary suckers which are charaoterized by a very rapid two-phase flow yand wherein the turbulence accompanying this flow results in substantial damage to the red cells of the blood.
It would be noted in connection with the oxygenator of FIG. 2 that only a very shallow pool of blood is needed to achieve filming over the inner and outer surfaces of the rotating cylinders. This means, in effect, that the system requires a small priming volume of blood. Moreover, since only a small fraction of these cylinders is under the blood at any one time, almost all of their surface areas are available for oxygenation. In order to minimixe foaming of the blood, these cylinders in one practical embodiment of the invention were made of stainless steel and coated with a silicone lacquer which was sprayed on and thereafter baked to give a plasticlike surface. The wall thickness of these cylinders was approximately onethirty-second of an inch. ln order to minimize hemolysis 5. which occurred when the cylinders were rotated at approximately 50 rpm., fine stainless steel wires 131 and 132, shown in FIG. 2, were welded around the circumference of cylinders d0 and 41 near each end thereof. This reduced the contact between adjacent cylinders to only two isolated points.
The oxygenator of FIG. 2 can be constructed with the three cylinders concentrically disposed about the same longitudinal axis which can correspond to drive shaft 44. In this case, the inner tWo cylinders would, like outer cylinder 39, lit into suitable slots cut in the inner face of the spiders. Also, the innermost cylinder could be of solid construction. By avoiding completely any contact between the cylinders, a more gentle form of oxygenation and higher rotational rate may be achieved Without foaming. The solid construction of the inner cylinder, of course, diminishes the priming volume.
The advantage of using a bellows-type engine, such as the simplified version illustrated in FIG. 1, to drive the camshaft, is found in the fact that this construction presents no gas sealing problems. However, there is a tendency for the bellows to squirm and introduce slight irregularities in the operation of the oxygenator. If desired, this engine can be replaced with a conventional piston-type engine wherein the oxygen is led to and from the cylinder head via a flexible plastic tube. In one practical embodiment of such an engine, the cylinder was made of brass, the piston of carbon, and sealed ball bearings of stainless steel construction were employed. It would be noted in connection with the operation of the engine portion of the system that a higher engine speed adds greatly to the stability of the apparatus and that the engine preferably should run at several times the frequency of the various pumps. This relationship can be, of course, ob-
tained by incorporating suitable gearshift provisions in theV drive mechanism.
. lt has been found in the operation of the apparatus ofY FIG. 1 that the tubing 54 connected to the bottom of the reservoir should be of fairly large diameter, approximately two inches, so that any oxygen bubbles entrapped in the blood when the blood level is below the bottom of the reservoir can be released readily by com-ing to the surface. Such a tube dimension has the effect of increasing the volume of blood needed in the operation of the system. However, reservoir 5 can be eliminated from the system with a gravity iow of blood directly from the oxygenator to pressure pump 6.
In FIG. 3 there `is schematically depicted ya modification of the internal portion of the oxygenator of FIG. 1. In this alternative construction, a single, rotating cylinder 82, the counterpart of element 39, is covered with a stocking 83 made of loosely woven, plastic material. This stocking, which preferably should be about three-quarters of an inch thick, performs much like a screen except that the.
weave is loose enough so that each fiber is individually coated with blood as the stocking dips into the blood pool. Thus, while each fiberV is wetted by the blood, the blood cannot bridge across adjacent fibers so as to form, in effect, a single large blood clot around cylinder 82.
A flow-through pressure pump which can replace the apparatus of FIG. 4 in the oxygenating system is illustrated in FIG. 5. In this alternative construction, a cylinder 85 having an inwardly projecting, rounded collar 86 adjacent each end thereof encloses a tubular element S7, preferably made of plastic or silicone rubber. This tubular element, which is closed off at each end by Ia stopper $8 provided with a central bore 89, is held under tension With portions adjacent each end thereof pinched between confronting surfaces of stopper 8S and collar S6. Oxygenated blood is fed into one side of the pump and pressurized oxygen is fed into the interior of the pump via an entrance port 9d out in the Wall of cylinder 85 at a point intermediate its length. Each pumping stroke occurs, of course, when an oxygen pressure pump collapses tubular element $7 and forces the blood out of the exit side of the pump.
l Some of the characteristics of the embodiment of FIG which recommend its employment `include the unidirectional flow of blood, the simple form of the tubular pumping member and the ability of this member to withstand numerous sterilizations. The arrangement of FIG. 5 can be slightly modified by utilizing a tubular pumping element sealed at one end thereof in place of the open-ended element $7. Y With such a design, cylinder 85 would also be closed at a corresponding end thereof. Such a construction eliminates the need of the second stopper and minimizes any possible oxygen leakage from the pump. However, the cleansing operation is complicated because of the difficulty in turning such a closed tubular member inside out.
In FIG. 6 there is illustrated one arrangement for detachably connecting the oxygenator 41 as a unit to the oxygen-driven engine. Here, engine 2 and all of its conventional components, including, for example, the piston, cylinder and crankshaft, as well as camshaft 24 and ball valve assembly 3, are all accommodated within the rectangular engine block 91. End plate 38 of the oxygenator is secured by a pair of screws 92, only one of which is shown, to that face of the block through which the drive shaft of the engine projects. A circular flange 93 and a tubular arm 94 extend from the left-hand side of this end plate as viewed in this figure. The other end plate 37 has a similar but somewhat wider circular flange 103 projecting therefrom which has a blood collecting well portion 95 formed along the bottom part thereof. Secured to the other side of end plate 37 is a sleeve 96.
The outer glass, stationary cylinder 36 of the oxygenator lits closely Within flanges 93 and 103, extending sutiiciently far enough under these flanges to prevent any blood leakage from the central portion of the oxygenator. This cylinder is further sealed in place during the operation of the oxygenator by strips of pressure-sensitive plastic tape 97 which adhere to adjacent portions of the outer surface of this cylinder and the edges of the flanges. The oxygenator unit is held together by an L-shaped member 9S which consists Vof a tubular arm 99, whose diameter is slightly larger than that of arm v94 extending from end plate 3S, anda second arm 100 at right angles thereto which is designed to slidably lit within sleeve 96. Locking screw 101, which passes through aligned apertures in arms 99 and 94 when they are in the telescopic position shown, and set screw 102 of sleeve 96, maintain the assembly together. The oxygenator unit, it will thus be seen, can be detached asV a unit from the engine by means of screws 92, and the oxygenator itselt` can be disassembled for cleaning and inspection purposes by rst loosening screw 101, then set screw 102, and then unwrapping the plastic tapes 97. By the same token, it will be appreciated that the oxygenator unit, after it has been inspected and cleaned, can be reassembled and stored in a sterile condition until it is next needed. f
A modification of the present invention wherein the competence of flow-through pressure pump 6, which sends oxygenated blood to the surge chamber 8 and thence to the patient, is automatically controlled by the level of the Y of a pair of screws 112, only one of which is shown, whichV extend through a stationary platform 106 secured to the upright post of a stand 104. The purpose of supporting the complete assembly on only these two points is to permit the axis of the oxygenator to tilt with respect to the horizontal Vin responseto the amount ofV blood within it. This movement is utilized to control the rate of pumping. The mass of oxygenator 4 plus that of appended pressure pump 6 and surge chamber S, which, although not shown, is disposed side by side with this pump, is more than enough to overbalance the engine block 91 on the twopoint suspension provided by screws 112. But theV syss,ies,sos
tem can be brought to an even attitude by adjusting screw 114 which regulates the tension of spring 113 and the downward force acting on the engine block on the other side of the point supports. y
With pressure pump 6 suspended below the oxygenator, oxygenated blood can flow directly from well 9S, down through supporting tube 117 and via the one-way flapper valve 118 into the central portion of the pump. The oxygen for operating this pump, as shown in FIG. 5, is supplied to the annular space between rubber tube 57 and metallic housing SS by exible tube 116. This oxygen, as mentioned hereinbefore, cornes from the engine exhaust, and it first passes throughk a one-way flapper valve, similar to 118, before it enters this branch line. The operation of pump 6 is controlled by throttling its exhaust. To accomplish this, line 116 is also connected via an internal passageway in engine block 91, not shown, to a horizontal tube 109 that extends to the right, as viewed in this ligure, from the lower edge of the engine block. Tube V109, which is the exhaust line for pump 6, terminates at its outer end in a valve assemblyV whose closure member is ball 111. It will be readily appreciated that when ball 111 rests on its seat, closing-valve 110, oxygen cannot be exhausted from pump 6 since there is no other exit from this pump due to the blocking action of thecheck Valve previously mentioned. Tubular member 87, therefore, must remain in a compressed condition and, consequently, the pump cannot prepare itself for a second stroke.
The apparatus for controlling valve 110 consists merely of a horizontal arni 107 that extends from iixed platform 106 in a direction parallel to tube 109. This arm carnies an adjustable screw 108 at a position immediately below the center of the seat of valve 110, and the Vend of this screw is designed so it can pass into this valve and contact ball 111. Horizontal arm 107 also carries a strap which loops over tube 109 so as to limit the counterclockwise rotation of the apparatus about point supports 112.
When the apparatus is rst put in operation, that is, with little or no blood in the oxygenator, spring 113 counteracts the overbalancing action of the oxygenator Y plus its appended equipment, and the apparatus assumes a generally horizontal attitude. Pressure pump 6 is incapacitated at this time because its exhaust line is completelyclosed, with ball 111 resting on its seat and completely out of contact with the tip of screw 10S. As the blood level rises in the oxygenator, the increased weight thereof contributes to the mass of the apparatus on the right of the supporting points, as viewed in FG. 7; the above balance is disturbed and the oxygenator and the engine block commence to rotate in a clockwise direction about the pvot points. Since exhaust pipe 109 is attached to the engine block, it, too, takes part in this rotation. As more and more blood flows into the oxygenator, the angular displacement of the above apparatus increases until a point is reached at which pipe 109 is tilted suiiciently far to bring the top part of screw 108 into contact with ball 111. The amount of blood at this point is now close to the level considered safe for operation of the system. Any further flow of blood now results in valve 110 being cracked by the upward movement of ball 111 off of its seat, and the pump commences to operate at a relatively low rate. This rate increases with further opening of valve 110 until the exhaust line is completely opened. I
if the level of the blood in the oxygenator decreases at any time below the safe level so that there fis the danger vof oxygen gas being sucked into the pump, the oxygenator rotates in a counterclockwise direction, Contact is broken between ball 111 and screw 103, Iand pump 6 is stopped. In actual operation, the oxygenator assumes a position in which the ball valve is continuously tickled by pressure of the screw, and the pump `operates with `partial capacity to maintain the .blood level fairly constant. It would be pointed out that the blood leaves pump 6 via a one-way flap-per valve 1,19 and then proceeds to the surge chamber 8 which has a general appearance similar to that of pump 6 as illustrated in FIG. 5. This surge chamber, as mentioned hereinbefore, is positioned alongside pump i6 and also suspended from oxygenator 4. It would be pointed out that in the operation of the above system the apparatus is first charged with a sterile saline solu-tion and then with blood.
Obviously many modifications and variations of the present invention are possible in the light of the above teachings. It is therefore to be understood that within the scope of the appended claims the invention may be practiced otherwise than as specifically described.
What is claimed is:
1. For use in a system that assumes the functions of the lungs of a patient during surgery, the combination of a cylindrical container, said container adapted to contain a pool of blood being positioned in a substantially horizontal attitude, means for forming a pool of blood at the bottom of said container thereof, a first sleeve mounted between opposite end walls of said container, means for rotating said sleeve about an axis that is parallel to but below the longitudinal axis of symmetry of said container, the location of said axes with respect to the surface of said pool of blood being such that a wall length portion of said sleeve extends into said blood pool whereby the inner and outer wall surfaces of said sleeve become covered with a thin film of blood after a few rotations of said sleeve, a second sleeve positioned Within said first sleeve, a loop of Wire secured around the outer surface of said second sleeve adjacent each end thereof, said loops of Wire freely resting on a portion of the inner Wall surface of said first sleeve whereby a finite separation between the lower inner wall surface of said first sleeve and a confronting portion of the outer wall surface of said second sleeve is established and .whereby said second sleeve rotates in response to the rotation of said first sleeve, means for establishing a continuously fresh oxygen atmosphere Within said enclosed container and means for withdrawing blood from said pool.
2,. In an oxygenating system, the combination of an enclo-sed cylindrical container adapted to contain a pool of blood, means for accumulating said pool of blood at the bottom of said container, a holler cylinder mounted Within said container with a Wall length portion thereof adapted to extend into said pool of blood, a source of compressed oxygen, means responsive to Ithe expansion of a stream of oxygen released from said source for imparting rotary motion to said hollow cylinder whereby Ithe inner and outer wall surfaces thereof become coated with a thin film of blood after a few rotations of said cylinder and means for directing the released oxygen after its expansion into said container thereby to oxygenate the blood forming said thin films.
3. In a system for temporarily assuming the functions of a patients heart and lungs during surgery, the cornbination of a blood oxygenator adapted to contain a pool of blood, said oxygenator including as a component thereof a hollow cylinder adapted to rotate partially Within said pool of blood, an engine rotating said cylinder, a suction pump for collecting blood seeping into the operating area and adding this blood to said blood pool, a pressure pump, said pressure pump `being connected to said oxygenator and adapted to be connected lto the arterial system of said patent, a source of compressed oxygen, said vacuum pump, said engine and said pressure pump being operated by .the expansion of compressed oxygen from said source, said oxygen after its expansion serving to oxygenate the blood within said oxygenator.
4. In a system for temporarily assuming the heart and 4lung actions of a patient during surgery, the combination of a blood oxygenator, adapted to contain a pool of blood, said `oxygenator including a sleeve, means for dispersing the blood which is to be oxygenated in a thin film over the inner and outer wall surfaces of said sleeve, means for rotating said sleeve partially within a blood pool, a pressure pump connected to said oxygenator and adapted to be connected to said patient yfor pumping blood from said oxygenator into the arterial system of the patient, a source of compressed oxygen, said means for rotating said sleeve and said pump being operated by the expansion of compressed oxygen Ifrom said source, said oxygen after its expansion serving to oxygenate the blood films on the inner and outer wall surfaces of said sleeve.
5. In an arrangement as defined in claim 4, a suction pump, said suction pump adopted to remove blood collecting in the operating area and adopted to add this blood to the blood pool Within said oxygenator, said pump also being operated by the expansion of compressed oxygen from said source.
6. In an arrangement as defined in claim 5, means for directing the blood from said pressure pump against a cushioning member whereby the flow of said blood is smoothened prior to its introduction into the arterial system of 4the patient.
7. For use in a system for temporarily assuming the functions of a patients lungs, the combination of a blood oxygenator adapted to contain a pool of blood, said oxygenator including a blood dispersing member adapted to rotate partially within said blood pool, means lfor enclosing said dispersing member in an oxygen atmosphere, a source of compressed oxygen, an engine for rotating said dispersing member, said engine being operated by the expansion of compressed oxygen supplied from said source within a compartment thereof, said oxygen after its expansion being coupled to said means for enclosing said dispersing member, thereby to provide said oxygen atmosphere.
8. In an arrangement as defined in claim 7, a pressure pump connected to said oxygenator, said pressure pump when connected to said patient forcing blood Withdrawn from said pool into the arterial system of said patient, said pump operating by the expansion of compressed oxygen, and means for cutting off the dow of blood to said pump when the blood level of said pool falls 'below a predetermined value.
9. A blood oxygenating system for a patient undergoing surgery, comprising a blood oxygenator, a blood supply line for feeding blood into said oxygenator, means for collecting blood seeping into the operating area and for adding this blood to said blood supply line thereby to augment the blood available in the oxygenator, said last-mentioned means including a source of compressed oxygen, a suction pump, said suction pump being operated by the expansion o-f compressed oxygen fed there to from said source, and means for coupling said suction pump to said oxygenator whereby the oxygen employed to operate said suction pump is subsequently vented into said oxT genator.
10. In a system for oxygenating the blood of a patient undergoing surgery, the combination of a blood oxygenator adapted to contain a pool of blood, a supply line adapted to connect the venous system of said patient to said blood oxygenator whereby blood flows by gravity from said patient into said oxygenator, a syphon, said syphon collecting blood seeping into the operating area and feeding it into said supply line thereby to increase the blood within said oxygenator, a suction pump connected to 'said syphon for starting said syphon, said suction pump being operated by the expansion of compressed oxygen wlthin ya compartment thereof, and means for coupling the oxygen vented from said compartment between successive strokes of said suction pump into said oxygenator there- 'by to oxygenate the blood therein.
. 1l. In an oxygenator system, the combination of a blood oxygenator, a first blood supply line having one end connected to said oxygenator and the other end adapted to be connected to the venous system of a patient, said patient being elevated above the level of said oxyadsense genator whereby blood hows by gravity from said venous system into said oxygenator, an enclosed chamber, a sucion pump, the suction line thereof being connected to an opening in the top wall of said chamber, tubing connected between the bottom of said chamber and said first blood supply line, a second blood supply line, one end of said second blood supply line terminating in an aperture cut in one wall of said chamber and the other end adapted to terminate in the operating area whereby blood scoping into said area is sucked into said chamber by the vacuum developed therein by said suction pump, said ystorage -chamber being located in a position above said first blood supply line whereby blood flows from said chamber by gravity into said first blood supply line through said tubing and thereafter continues to flow by syphoning action until substantially all of the blood is removed from the operating arca.
12. In an arrangement as defined in claim 1l wherein said suction pump is operated by the expansion -of a compressed gas within a chamber thereof, a source of compressed oxygen, and means for periodically coupling compressed oxygen from said source to said compartment for operating said suction pump, and means for periodically venting oxygen from said compartment into said oxygenator.
13. Apparatus for use in oxygenating blood comprising, in combination, a tubular container closed at each end thereof, Ia first hollow cylinder mounted between opposits ends of said tubular container and adapted to rotate about a horizontal axis, a second hollow cylinder positioned within said first hollow cylinder, said second hollow cylinder being supported by said rst .hollow cylinder at only two spaced locations adjacent each end of said first hollow cylinder' such that a finite separation exists between the confronting lower wall surface portions of said first and second hollow cylinders, a blood inlet and outlet in the lower Wall portion of said tubular container, an adjacent gas inlet and outlet in the top wall portion of said tubular container, said inlets being adjacent one end of said container and said outlets being adjacent the other end of said container, means for rotating said first cylinder whereby said second cylinder tends to rotate therewith, said means including a gasoperated engine, said engine being of the type wherein the motive force is derived from the expansion of a compressed gas within a compartment of said engine, means for coupling compressed oxygen to said engine and means Vfor coupling said oxygen after its expansion to said gas tate about a horizontal axis, a second hollow cylinder positioned within said first hollow cylinder, said second hollow cylinder being supported by said first hollow cylinder at only ltwo spaced peripheral locations adjacent the ends of said first hollow cylinder such that a finite separation exists between the confronting lower wallv surface portions of said first and second hollow cylinders, a blood inlet and outlet in the lower wall portion of said tubularrcontainer, a gas inlet and outlet in the top wall portion of said Itubular container, said inlets being adjacent one end of said container and said outlets being adjacent said other ends of said containenmeans for rotating said first hollow fluid, means for connecting the blood outlet of said oxycylinder, said means including Ian engine, said engine be-l source to said compartment, thereby to operate Ysaid engenator Ito the input of said pump, the output of said pump being adapted to be coupled to the Iarterial system of the patient, and means for connecting a pulsating stream of oxygen derived from said source of pressurized oxygen to said pump.
16. For use in a blood oxygenating system for a patient undergoing surgery the combination of a blood oxygenator, -a first blood supply line, one end of said line being adapted to connect the patients venous system to said oxygenator, a suction pump, a blood storage chamber, means for coupling the suction side of said pump to the top of said storage chamber, means for connecting the bot-tom of said storage chamber to the other end of said first 4blood supply line, a second blood supply line, one end of said second line being connected -to an opening in one wall of said storage chamber and the other end of said line adapted to terminate inthe operating area whereby said suction pump during its operation creates a vacuum within said storage chamber toV draw blood seeping into said operating area into said storage cham-ber, the blood in said Vstorage chamber thereafter 'liowing by gravity into said supply line, an enclosed container, a liquid within said container, means connecting the suction side of said pump to an aperture cut in the top wall of said container, -a length of tubing, said tubing extending through an aperture cut in the top wall of said container and into said fluid for a predetermined distance whereby air is drawn through said tubing and through .said liquid into said suction line when the degree of vacuum within said chamber exceeds a predetermined amount, said suction pump being operated by the expansion of compressed oxygen Within a compartment thereof, means for periodically coupling compressed oxygen to said compartment and ymeans for subsequently venting oxygen after its expansion in said compartment into said oxygenator.
References Cited by the Examiner UNITED STATES PATENTS 2,286,480 6/412 Farr 261-92 y2,69?:,80Z. vlil/fillL Osborn 12S-2x14 2,702,035 -2/ 515 Gibbon et al 12S-214 2,812,716 ll/57 Gray 1128-2-14 2,927,582 3/60 lBerkman et al. 12S-2114 3,026,871 3/62 Thomas l28214 l3,037,504 6/62 Everett 12S-2M FOREIGN PATENTS 461,160 1/5-1 Italy.
OTHER REFERENCES Karlson et al.: Pump-Oxygenator to Supplant the Heart and Lungs for Brief Periods, from Surgery, vol. 29, No. 5, May '1, pp. 678-696.
Winterscheid et al.: A Coronary Sinus System for Use During Cardiopulrnonary Bypass, from L,urger vol. 48, No. 4, October 1960, pp.V785-795.
Crafoord et al.: Clinical Studies in Extra-Corporeal Circulation with a Heart-Lung Machine, from Acta Che rurgica Scandinavica, vol. 112, No. v34, pp. 22S-225.
RTCHARD A. GAUDET, Primary Examiner.
RICHARD J. HOFFMAN, Exmm'ner.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2286480 *||Jul 1, 1940||Jun 16, 1942||Farr Morrill N||Air purifier or conditioner|
|US2693802 *||May 15, 1951||Nov 9, 1954||John J Osborn||Blood oxygenation|
|US2702035 *||Feb 27, 1953||Feb 15, 1955||Jefferson Medical College||Oxygenating unit for extracorporeal circulation devices|
|US2812716 *||Dec 4, 1952||Nov 12, 1957||Donald E Gray||Pumping device|
|US2927592 *||Jul 15, 1957||Mar 8, 1960||Ferre Sr Roy S||Shock actuated valve|
|US3026871 *||Jan 27, 1959||Mar 27, 1962||Const Mecaniques De Stains Soc||Apparatus for oxygenating blood|
|US3037504 *||Oct 1, 1959||Jun 5, 1962||Foregger Company Inc||Extracorporeal blood circulation system having a non-electric drive|
|IT461160B *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3410263 *||May 13, 1965||Nov 12, 1968||Westinghouse Electric Corp||Blood-pumping apparatus provided with heart synchronizing means|
|US3437450 *||Jan 4, 1965||Apr 8, 1969||Greenwood James M||Hyperbaric heart pump oxygenator with hypothermia|
|US3466148 *||Feb 15, 1966||Sep 9, 1969||Everett Hazen F||Blood oxygenator|
|US3513845 *||Sep 15, 1966||May 26, 1970||United Aircraft Corp||Bypass heart pump and oxygenator system|
|US3515640 *||Feb 13, 1968||Jun 2, 1970||Craig R Rudlin||Combination pump and oxygenator|
|US3536451 *||Jan 21, 1965||Oct 27, 1970||Ludwin Isadore||System for cyclic pulsed pumping and fluid interaction|
|US3717174 *||Aug 3, 1971||Feb 20, 1973||R Dewall||Perfusion safety valve|
|US3771658 *||Oct 20, 1971||Nov 13, 1973||Brumfield R||Blood transport membrane pump|
|US3841837 *||Oct 5, 1972||Oct 15, 1974||Tecna Corp||Oxygenator|
|US3934982 *||May 21, 1974||Jan 27, 1976||Arp Leon J||Blood oxygenator|
|US4243883 *||Jan 19, 1979||Jan 6, 1981||Midwest Cardiovascular Institute Foundation||Blood hematocrit monitoring system|
|US4253456 *||Aug 21, 1978||Mar 3, 1981||Dr. Eduard Fresenius Chemisch-Pharmazeutisch Industrie Kg, Apparatebau Kg||Artificial endocrinal gland|
|US4627419 *||Aug 29, 1984||Dec 9, 1986||The Board Of Regents, The University Of Texas||Blood pump apparatus and method|
|US4755300 *||Dec 23, 1985||Jul 5, 1988||Haemonetics Corporation||Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear|
|US4769241 *||Sep 23, 1986||Sep 6, 1988||Alpha Therapeutic Corporation||Apparatus and process for oxygenation of liquid state dissolved oxygen-carrying formulation|
|US4808307 *||Feb 16, 1988||Feb 28, 1989||Haemonetics Corporation||Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear|
|US4919895 *||Jun 18, 1987||Apr 24, 1990||Alpha Therapeutic Corporation||Apparatus for oxygenation of liquid state dissolved oxygen-carrying formulation|
|US5034135 *||May 8, 1987||Jul 23, 1991||William F. McLaughlin||Blood fractionation system and method|
|US5263924 *||Sep 25, 1991||Nov 23, 1993||Baxter International Inc.||Integrated low priming volume centrifugal pump and membrane oxygenator|
|US5376263 *||Nov 2, 1993||Dec 27, 1994||William F. McLaughlin||Pump control apparatus for cellular filtration systems employing rotating microporous membranes|
|US5464534 *||Oct 12, 1993||Nov 7, 1995||William F. McLaughlin||Blood fractionation system and method|
|US5591404 *||Jul 23, 1993||Jan 7, 1997||Mathewson; Wilfred||Integrated low priming volume centrifugal pump and membrane oxygenator|
|US5783085 *||May 15, 1996||Jul 21, 1998||Estate Of William F. Mclaughlin||Blood fractionation method|
|US5817079 *||Feb 10, 1994||Oct 6, 1998||Mcneil-Ppc, Inc.||Selective placement of absorbent product materials in sanitary napkins and the like|
|US6863821||Feb 2, 2002||Mar 8, 2005||Baxter International Inc.||Shear-enhanced systems and methods for removing waste materials and liquid from the blood|
|US7182867||Jan 26, 2005||Feb 27, 2007||Baxter International Inc.||Shear-enhanced systems and methods for removing waste materials and liquid from the blood|
|US7494591||Apr 12, 2007||Feb 24, 2009||Baxter International Inc.||Shear-enhanced systems and methods for removing waste materials and liquid from the blood|
|US8777832||Mar 14, 2013||Jul 15, 2014||The University Of Kentucky Research Foundation||Axial-centrifugal flow catheter pump for cavopulmonary assistance|
|US8906300||Aug 13, 2012||Dec 9, 2014||The University Of Kentucky Research Foundation||Even perfusion pump-integrated blood oxygenator|
|US8961789||Dec 18, 2008||Feb 24, 2015||Baxter International Inc.||Systems and methods for performing hemodialysis|
|US20020167875 *||Apr 10, 2002||Nov 14, 2002||Jia-Shing Sheu||Optical disk drive with adaptive compensator|
|US20030146154 *||Feb 2, 2002||Aug 7, 2003||Julie Moriarty||Shear-enhanced system and methods for removing waste materials and liquid from the blood|
|US20060278581 *||Aug 21, 2006||Dec 14, 2006||Julie Moriarty||Shear-Enhanced Systems And Methods For Removing Waste Materials And Liquid From The Blood|
|US20070181500 *||Apr 12, 2007||Aug 9, 2007||Julie Moriarty||Shear-Enhanced Systems and Methods for Removing Waste Materials and Liquid from the Blood|
|US20100108606 *||Dec 18, 2008||May 6, 2010||Baxter International Inc.||Systems and methods for performing hemodialysis|
|EP0283850A2 *||Mar 9, 1988||Sep 28, 1988||Franco Maria Montevecchi||Device for the extra-corporeal oxygenation of blood and for cardiovascular assistance|
|U.S. Classification||422/45, 261/DIG.280, 128/DIG.300, 261/92|
|International Classification||A61M1/10, A61M1/32|
|Cooperative Classification||A61M1/32, Y10S128/03, A61M1/106, Y10S261/28|