|Publication number||US3249109 A|
|Publication date||May 3, 1966|
|Filing date||Nov 1, 1963|
|Priority date||Nov 1, 1963|
|Publication number||US 3249109 A, US 3249109A, US-A-3249109, US3249109 A, US3249109A|
|Inventors||Maeth Harry, Pennings Ralph David|
|Original Assignee||Maeth Harry, Pennings Ralph David|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (9), Referenced by (133), Classifications (24)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Ma 3, 1966 H. MAETH ETAL 3,249,109
TORI CAL DRESS ING Filed Nov. 1, 1963 HARRY MA ETH R. DAVID PENNINGS BY Vndrus 9f Star/ 52 A'f-ronwsvs INVENTORS United States Patent 3,249,109 TOPICAL DRESSING Harry Maeth, 101 Main, and Ralph David Pennings, 302 Main, both of Mosinee, Wis. Filed Nov. 1, 1963, Ser. No. 320,809 9 Claims. (Cl. 128-268) This invention relates to a pharmaceutical preparation and more particularly to a pharmaceutical preparation for topical application to mucous membranes.
It is often desired to apply a dressing to the mucous membranes of the body, such as the oral cavity. For example, it may be desired to apply a post-operative dressing following gum surgery, or to use a dressing for intraoral traumatic wounds. In the past, dressings to be used in the oral cavity were generally made of tinfoil and included a base plate material which required heat to adapt it to its position on the membrane. If the dessing included a medicament or therapeutic agent, leakage of the agent generally occurred and could not be controlled. This resulted in the incomplete application of the agent to the site of treatment and dispersion of the agent into the mouth and possible entry into the alimentary tract.
The present invention is directed to an adhesive dressing to be topically applied to the body and in particular to the mucous membranes, such as the oral cavity. More specifically, the dressing or pharmaceutical preparation includes a flexible adhesive base composed of hydrated gelatin and including a small amount of pectin. In addition, a medicament or therapeutic agent can be incorporated in the flexible base. The base material is applied to the membrane at the site of the treatment and will adhere to the moist membrane. To prevent loss of the medicament or therapeutic agent, a backing member is applied to the outer surface of the flexible base. The backing member may take the form of a generally inert fabric, such as glass fibers, muslin or the like.
The hydrated gelatin base, which serves as the vehicle for the medicament or therapeutic agent, is flexible and is very adhesive and will readily adhere to the surfaces of the oral cavity or other mucous membranes. The gelatin base will remain flexible for extended periods of time and will not crack or chip. Moreover, the base does not contain oils or essential oils which can be irritating or toxic to the patient.
The use of the fabric backing layer insures theproper dosage of the medicament or therapeutic agent and prevents the dispersion of the agent from the site of treatment, thereby preventing the dispersion of the agent into the mouth and possible entry into the alimentary tract.
The pharmaceutical preparation or dressing can be used as a post-operative dressing in gum surgery, as a dressing for intraoral traumatic wounds, for the management of soft tissue lesions in the mouth, and as an irradiation shield for the treatment of malignant conditions with X-ray. In addition, it can also be used for topical application to the skin for abrasions, burns, varicose ulcers, and the like.
Other objects and advantages will appear in the course of the following description.
The drawings illustrate the best mode presently contemplated of carrying out the invention.
In the drawings:
FIG. 1 is a perspective view of a dressing prepared in accordance with the invention;
I FIG. 2 is a modified form of the invention showing the dressing in the form of a roll; and
FIG. 3 is a second modified form of the invention showing the dress-ing in the form of a pre-cut strip.
3,249,109 Patented May 3 1966 FIG. 1 shows a dressing 1 to be used for topical applications and particularly to the mucous membranes of the body. The dressing has particular application to the mucous membranes of the oral cavity, but also includes other areas such as the vagina, rectum, etc.
The dressing 1 includes a flexible hydrated gelatin base 2 and a fabric backing member 3. The hydrated gelatin base 2 contains by weight, 10 to 40% gelatin, 5 to Water, 15 to 80% polyhydric alcohol and up to 15% pectin.
The preferred range of composition, in weight percent is as follows:
Percent Gelatin 1033 Water 50-85 Polyhydric alcohol 15-35 Pectin 1-4 The hydrated gelatin gives the base its consistency and bulk and serves as the vehicle for the incorporation of medicaments and therapeutic agents.
Pectin is a carbohydrate obtained from the dilute acid extract of the inner portion of the rind of citrus fruits or apple peel. Pectin consists chiefly of partially methoxylated polygalacturonic acids.
The pectin provides adhesive properties to the hydrated gelatin and enables the gelatin base to be readily applied to moist surfaces, such as the mucous membranes.
The polyhydric alcohol serves to prevent brittleness and retains the flexible characteristics of the material for extended periods. The polyhdric alcohol can be glycerin, polyoxyethylene, propylene glycol, sorbitol, ethylene glycol (when used externally), and the like.
It is also contemplated that the base 2 will include a pharmacologically active material such as a medicament or a therapeutic agent. More specifically, the pharmacologically active material may include enzymes such as hyaluronidase; vasoconstrictors such as epinephrine; bactericides; bacteristatics; antacids; anesthetics; corticosteroids; antibiotics; hemostats; fluorides such as sodium fluoride, stannous fluoride, calcium fluoride; astringents, hormones; vitamins; tissue growth promoters such as Peruvian balsam; deodorants such as charcoal, and chlorophyll, and the like. The pharmacologically active material is used in an amount up to 10% by weight of the composition with the particular amount depending on the activity of the material.
The backing member 3 is formed of an inert, non toxic fibrous material such as glass fiber, muslin and the like. The use of glass fiber cloth has proven particularly satisfactory as a reinforcement and as a dam to reduce the spreading of the pharmacologically active material bility and a marked resistance to steam, corrosive fumes and most acids. In addition, the glass fiber will not absorb water and can be readily sterilized and re-sterilized and withstands repeated folding and creasing.
The fabric backing member 3 serves as a barrier and assures that the proper dosage of the medicament or therapeutic agent is supplied to the site to be treated. The backing member 3 prevents the agent from being dispersed into the mouth and prevents the entry of the agent into the alimentary tract.
To prepare the dressing of the invention, the gelatin and a portion of the Water and glycerin are mixed at an elevated temperature of about C. to form a gelatin component. ing portion of the water and glycerin to form a pectin component which is then added to the heated gelatin component. In some cases it may be desirable to add a The pectin is then mixed with the remainsmall amount, in the range of 1 to 2% of the total composition weight, of alcohol, such as ethyl alcohol, to the pectin component. The alcohol provides a rapid hydration of the pectin and can be omitted, but, if omitted, increases the time required for preparation.
After adding the pectin component to the gelatin component, the medicament or therapeutic agent is added as a solution or suspension, depending upon the particular agent used. The entire composition is then agitated to thoroughly mix the components and is subsequently poured into the desired mold and cooled. The backing member 3 is then overlayed onto the base material.
Example 1 As a specific example of the preparation, 30 grams of gelatin, 30 cc. of distilled water and 30 cc. of glycerin were mixed together and heated to a temperature of 90 C. to melt the gelatin. After the gelatin was melted, the pectin component consisting of 5 cc. of ethyl alcohol, 40 cc. of distilled water, cc. of glycerin and 5 grams of pectin was added to the liquid gelatin component and mixed therewith.
After adding the pectin component, 8 grams of Benzocaine and 40 cc. of alcohol, and 0.5 gram of Triburon (triclobisonium chloride) in 10 cc. of distilled water were added to the composition. After mixing in the Benzocaine and Triburon, the composition was poured into a mold and cooled. A glass fiber backing sheet was then overlayed over the composition and pressed firmly therein.
The resulting dressing was flexible and very adhesive and could readily be applied to mucous membranes.
Example 2 Three grams of pectin, 10 cc. of ethyl alcohol, 80 cc. of distilled water and 40 cc. of glycerin were mixed together. Forty grams of gelatin were added to this mixture and the entire composition heated to a temperature of 90 to 100 C. to melt the gelatin. Subsequently, 0.25
gram of Triburon in 17 cc. of glycerin and 20 cc. of distilled water were added to the gelatin-pectin composition. The resulting composition was then poured onto a suitable mold and cooled.
FIG. 2 shows a modified form of the invention in which the dressing is in strip form. In this embodiment the dressing includes a hydrated gelatin base 4 similar in composition to gelatin base 2 of the first embodiment. A fabric backing member 5 is applied to one surface of the base 4 and the backing member 5 is similar in structure and function to the backing member 3 of the first embodiment. In addition, a protective strip of material, such as waxed paper or other material, is applied to the outer surface of the barrier and serves to prevent the strip from sticking to itself when it is wound in spiral form.
The strip shown in FIG. 2 can be unwound as desired and cut to any length, depending on the nature of the site to be treated.
FIG. 3 shows a second modified form of the invention in which the dressing is in the form of a pre-cut strip. In this embodiment, the hydrated gelatin base 7, similar to base 2 of the first embodiment, is applied to an adhesive backing member 8. In this embodiment, a protective strip of material is applied to the adhesive surface of the strip 8 and can be removed immediately prior to application of the strip to the body surface.
The dressing of the invention is used for topical application, and particularly to the moist mucous membranes. For example, the dressing can be used as a post-operative dressing following surgery, as a dressing for traumatic wounds, 'as a dressing for soft tissue lesions and it also may be employed as an irradiation shield for the treatment of malignant conditions with X-ray. In this lattercase, a radiation barrier, such as powdered lead or barium sulphate, can be incorporated in the flexible base 2 in an amount of about 10 to 30% by weight of the base. The lead or barium sulphate is radiopaque material and serves as an irradiation shield to protect structures such as teeth and soft tissues from the radiation. This type of barrier is considerably more flexible and pliable than sheet lead for intraoral use, and being a lightweight material, is exceedingly more comfortable to the patient.
The dressing of the invention is flexible and will tightly adhere to moist membrane surfaces. If the dressing is to be applied to the external body tissues, it may be necessary to moisten the tissue before application.
It is contemplated that pharmacologically active materials can be incorporated in the hydrated gelatin base and the backing member serves to concentrate the activity of the material at the site of treatment and prevents the pharmacologically active material from dispersing outwardly into the mouth or other regions of the body.
Various modes of carrying out the invention are contemplated as being within the scope of the following claims particularly pointing out and distinctly claiming the subject matter which is regarded as the invention.
1. A pressure sensitive dressing for topical application, comprising a solid, flexible hydrated gelatin base capable of maintaining its shape and containing a suflicient amount of pectin to provide initial adhesiveness for application to moist tissue and containing a sufiicient amount of a polyhydric alcohol to maintain flexibility for extended periods, and a generally inert non-toxic fibrous backing member disposed on one surface of said base and serving to prevent the outward dispersion of materials from the base.
2. A dressing for topical applications, comprising a solid, flexible, adhesive, film-like, hydrated gelatin base consisting essentially by weight of 10 to 40% gelatin, 5 to 85% water, 15 to of a polyhydric alcohol, and up to 15% pectin, and a fibrous backing member applied to one surface of the base, said backing member reinforcing the base and serving to prevent the outward dispersion of materials from the base.
3. The structure of claim 2, in which the hydrated gelatin base contains up to 10% by weight of a pharmacologically active material, said backing member serving to concentr-ate the pharmacologically active material at the site of treatment and preventing the outward dispersion of said material.
4. The structure of claim 2, in which the polyhydric alcohol is selected from the group consisting of glycerin, polyoxyethylene, propylene glycol, ethylene glycol, and sorbitol.
5. The structure of claim 3, in which the backing member is composed of glass fiber fabric.
6. A pressure sensitive dressing for topical applications, comprising a nonflow-able flexible, adhesive, hydrated gelatin sheet consisting essentially by weight of 10 to 33% gelatin, 50 to water, 1 to 4% pectin, 15 to 35% glycerin, and up to 10% of a pharmacologically active material, and a fabric backing member applied to one surface of the hydrated gelatin sheet, said backing member serving to concentrate the pharmacologically active material at the site of treatment and preventing the outward dispersion of said material.
7. The structure of claim 6 in which the hydrated gel-atin sheet also includes from 1 to 2% by weight of alcohol.
8. A dressing for topical applications, comprising a flexible, adhesive, hydrated gelatin base consisting essentially by weight of 10 to 40% gelatin, 5 to 85% Water, 15 to 80% of a polyhydric alcohol, up to 15% pectin and from 10 to 30% by weight of a material selected from the group consisting of lead and barium sulfate, and a fibrous backing member applied to one surface of the base, said backing member reinforcing the base and serving to prevent the outward dispersion of the material from the base, said material serving as a radiation shield to protect portions of the body from radiation.
9. A pressure sensitive article, comprising a flexible, adhesive, hydrated gelatin base containing up to 30% by weight of a radiopaque material, and a fabric backing member applied to one surface of the hydrated gelatin base, said backing member serving to concentrate the radiopaque material at the site of treatment and prevent the outward dispersion of said materiaL-said mtaerial serving as a radiation shield to protect portions of the article from radiation.
References Cited by the Examiner UNITED STATES PATENTS 307,537 11/1884 'Foulks 167 84 335,799 2/ 1886 Baby. 2,115,237 4/1938 Scholl 128268 X 6 Donaldson 1'28156 Shrontz 128-268 Reese.
Hirsch 106-125 Steinhardt 32--2 X FOREIGN PATENTS Germany.
OTHER REFERENCES Macleods Physiology in Modern Medicine, Bard, 8th edition, 1938.
ROBERT E. MORGAN, Primary Examiner.
15 RICHARD A. GAUDET, Examiner.
C. F. ROSENBAUM, Assistant Examiner.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US307537 *||Nov 4, 1884||Dental capsicum-bag|
|US335799 *||Oct 26, 1885||Feb 9, 1886||Itnesses|
|US2115237 *||May 11, 1936||Apr 26, 1938||Scholl William M||Medicated button|
|US2450083 *||Feb 7, 1944||Sep 28, 1948||Munising Paper Company||Treated paper liner for adhesive rolls|
|US2501544 *||Oct 23, 1946||Mar 21, 1950||Shellmar Products Corp||Therapeutic product|
|US2583341 *||Mar 21, 1950||Jan 22, 1952||Reese John D||Skin graft receiving member|
|US2950980 *||Sep 10, 1958||Aug 30, 1960||Arthur Hirsch||Adhesive compositions|
|US3029187 *||Feb 20, 1958||Apr 10, 1962||Amos Steinhardt||Gelating adhesive pharmaceutical preparations|
|DE1074979B *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3329145 *||Feb 12, 1965||Jul 4, 1967||Johnson & Johnson||Sanitary napkin having control element with gel-forming material|
|US3339546 *||Dec 13, 1963||Sep 5, 1967||Squibb & Sons Inc||Bandage for adhering to moist surfaces|
|US3444858 *||May 11, 1966||May 20, 1969||Higham S Russell||Method and means for administering drugs|
|US3598123 *||Apr 1, 1969||Aug 10, 1971||Alza Corp||Bandage for administering drugs|
|US3688406 *||Aug 7, 1970||Sep 5, 1972||Frank W Hindsley||Apparatus for and method of applying decay retardant compositions to teeth|
|US3696811 *||Jun 17, 1971||Oct 10, 1972||Squibb & Sons Inc||Periodontal bandage and backing therefor|
|US3769071 *||Jun 4, 1971||Oct 30, 1973||Minnesota Mining & Mfg||Pressure sensitive adhesive tape comprising 5-fluorouracil|
|US3960150 *||Sep 15, 1975||Jun 1, 1976||Alza Corporation||Bioerodible ocular device|
|US3981303 *||Jul 31, 1975||Sep 21, 1976||Alza Corporation||Bioerodible ocular device|
|US3986510 *||Aug 1, 1975||Oct 19, 1976||Alza Corporation||Bioerodible ocular device|
|US3993071 *||Jul 24, 1975||Nov 23, 1976||Alza Corporation||Bioerodible ocular device|
|US3993073 *||Mar 3, 1975||Nov 23, 1976||Alza Corporation||Novel drug delivery device|
|US3996934 *||Aug 9, 1971||Dec 14, 1976||Alza Corporation||Medical bandage|
|US3998215 *||Apr 23, 1971||Dec 21, 1976||Minnesota Mining And Manufacturing Company||Bio-medical electrode conductive gel pads|
|US4022203 *||Jan 22, 1976||May 10, 1977||Win Ackley||Treated patch for minor cuts|
|US4062361 *||Jul 7, 1975||Dec 13, 1977||Coloplast International A/S||Bilaminar ostomy sealing disc|
|US4239488 *||Jun 15, 1979||Dec 16, 1980||Sempler Vance A||Encapsulated denture adhesive and method of use|
|US4253460 *||Jul 27, 1979||Mar 3, 1981||E. R. Squibb & Sons, Inc.||Ostomy adhesive|
|US4265233 *||Apr 6, 1979||May 5, 1981||Unitika Ltd.||Material for wound healing|
|US4292299 *||Jul 7, 1980||Sep 29, 1981||Teijin Limited||Slow-releasing medical preparation to be administered by adhering to a wet mucous surface|
|US4306551 *||Jul 28, 1980||Dec 22, 1981||Lectec Corporation||Sterile improved bandage and sealant|
|US4307717 *||Jul 28, 1980||Dec 29, 1981||Lectec Corporation||Sterile improved bandage containing a medicament|
|US4321252 *||Dec 17, 1980||Mar 23, 1982||Key Pharmaceuticals, Inc.||Polymeric diffusion matrix containing ester derivatives of estradiol|
|US4329333 *||Nov 24, 1980||May 11, 1982||Arthur Barr||Method for the oral treatment of dogs and other animals|
|US4460562 *||Mar 30, 1983||Jul 17, 1984||Key Pharmaceuticals, Inc.||Polymeric diffusion matrix containing propranolol|
|US4470962 *||Apr 28, 1981||Sep 11, 1984||Key Pharmaceuticals, Inc.||Polymeric diffusion matrix|
|US4492685 *||Jan 30, 1984||Jan 8, 1985||Key Pharmaceuticals, Inc.||Protective skin matrix|
|US4631227 *||Dec 5, 1983||Dec 23, 1986||Kenji Nakamura||Toilet article|
|US4655211 *||Aug 8, 1985||Apr 7, 1987||Unitika Ltd.||Hemostatic agent|
|US4695465 *||Apr 5, 1985||Sep 22, 1987||Takeda Chemical Industry, Ltd.||Soft patch|
|US4728323 *||Jul 24, 1986||Mar 1, 1988||Minnesota Mining And Manufacturing Company||Antimicrobial wound dressings|
|US4877618 *||Mar 18, 1988||Oct 31, 1989||Reed Jr Fred D||Transdermal drug delivery device|
|US4906475 *||Feb 16, 1988||Mar 6, 1990||Paco Pharmaceutical Services||Estradiol transdermal delivery system|
|US4984570 *||Sep 14, 1989||Jan 15, 1991||Karl Otto Braun Kg||Knitted hydrophobic web wound dressing|
|US4991574 *||Aug 15, 1990||Feb 12, 1991||Dow Corning Corporation||Surgical dressing|
|US5096715 *||Nov 20, 1989||Mar 17, 1992||Alko Ltd.||Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist|
|US5207652 *||Oct 23, 1991||May 4, 1993||Bioderm||Medical apparatus fixation and infection control device|
|US5234957 *||Dec 23, 1991||Aug 10, 1993||Noven Pharmaceuticals, Inc.||Compositions and methods for topical administration of pharmaceutically active agents|
|US5332576 *||May 21, 1993||Jul 26, 1994||Noven Pharmaceuticals, Inc.||Compositions and methods for topical administration of pharmaceutically active agents|
|US5336501 *||Apr 29, 1992||Aug 9, 1994||Lohmann Gmbh & Co. Kg||Cross-linked hydrogels and their use as wound dressings|
|US5437621 *||Jan 12, 1993||Aug 1, 1995||Marmon Holdings, Inc.||Medical dressing of a multilayered material|
|US5446070 *||Aug 27, 1993||Aug 29, 1995||Nover Pharmaceuticals, Inc.||Compositions and methods for topical administration of pharmaceutically active agents|
|US5480377 *||Feb 28, 1994||Jan 2, 1996||New Dimensions In Medicine, Inc.||Wound dressing having a roll configuration|
|US5536263 *||Mar 30, 1994||Jul 16, 1996||Lectec Corporation||Non-occulusive adhesive patch for applying medication to the skin|
|US5741510 *||Apr 8, 1996||Apr 21, 1998||Lectec Corporation||Adhesive patch for applying analgesic medication to the skin|
|US5829442 *||Jun 12, 1996||Nov 3, 1998||Medical Concepts Development, Inc.||Antimicrobial containing solventless hot melt adhesive composition|
|US6016862 *||Mar 10, 1999||Jan 25, 2000||Hormel Foods Corporation||Collagen or gelatin crumble composition and uses|
|US6090915 *||Oct 18, 1996||Jul 18, 2000||Hormel Foods Corporation||Collagen or gelatin crumble composition and uses|
|US6096333 *||Oct 8, 1997||Aug 1, 2000||Lectec Corporation||Method of forming adhesive patch for applying medication to the skin|
|US6096334 *||Dec 14, 1998||Aug 1, 2000||Lectec Corporation||Adhesive patch for applying medication to the skin and method|
|US6469227||May 12, 2000||Oct 22, 2002||Lectec Corporation||Antipruritic patch|
|US6607746||Jul 24, 2002||Aug 19, 2003||Medical Concepts Development, Inc.||Antimicrobial containing solventless hot melt adhesive composition|
|US6664309||Dec 7, 2000||Dec 16, 2003||Bostik Findley, Inc.||Antimicrobial hot melt adhesive|
|US7087269||Jun 22, 2001||Aug 8, 2006||Lg Chemical Co., Ltd.||Multi-component composite membrane and method for preparing the same|
|US7157614||Dec 21, 2001||Jan 2, 2007||Fountainhead, Llc||Treatment devices providing targeted antimicrobial action|
|US7357891||Jan 30, 2004||Apr 15, 2008||Monosol Rx, Llc||Process for making an ingestible film|
|US7425292||Feb 14, 2002||Sep 16, 2008||Monosol Rx, Llc||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US7666337||May 28, 2004||Feb 23, 2010||Monosol Rx, Llc||Polyethylene oxide-based films and drug delivery systems made therefrom|
|US7824588||Apr 14, 2008||Nov 2, 2010||Monosol Rx, Llc||Method of making self-supporting therapeutic active-containing film|
|US7910641||Dec 14, 2006||Mar 22, 2011||Monosol Rx, Llc||PH modulated films for delivery of actives|
|US7972618||Sep 20, 2007||Jul 5, 2011||Monosol Rx, Llc||Edible water-soluble film containing a foam reducing flavoring agent|
|US8017150||Apr 22, 2008||Sep 13, 2011||Monosol Rx, Llc||Polyethylene oxide-based films and drug delivery systems made therefrom|
|US8475832||Aug 7, 2009||Jul 2, 2013||Rb Pharmaceuticals Limited||Sublingual and buccal film compositions|
|US8603514||Jul 10, 2007||Dec 10, 2013||Monosol Rx, Llc||Uniform films for rapid dissolve dosage form incorporating taste-masking compositions|
|US8614179||Jul 17, 2009||Dec 24, 2013||E-Therapeutics Plc||Antibacterial combination therapy for the treatment of gram positive bacterial infections|
|US8652378||Mar 29, 2013||Feb 18, 2014||Monosol Rx Llc||Uniform films for rapid dissolve dosage form incorporating taste-masking compositions|
|US8663687||May 13, 2010||Mar 4, 2014||Monosol Rx, Llc||Film compositions for delivery of actives|
|US8685437||Mar 26, 2009||Apr 1, 2014||Monosol Rx, Llc||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US8765167||Sep 8, 2006||Jul 1, 2014||Monosol Rx, Llc||Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions|
|US8900497||Aug 23, 2013||Dec 2, 2014||Monosol Rx, Llc||Process for making a film having a substantially uniform distribution of components|
|US8900498||Aug 23, 2013||Dec 2, 2014||Monosol Rx, Llc||Process for manufacturing a resulting multi-layer pharmaceutical film|
|US8906277||Aug 23, 2013||Dec 9, 2014||Monosol Rx, Llc||Process for manufacturing a resulting pharmaceutical film|
|US8974826||Jun 10, 2011||Mar 10, 2015||Monosol Rx, Llc||Nanoparticle film delivery systems|
|US9108340||Aug 23, 2013||Aug 18, 2015||Monosol Rx, Llc||Process for manufacturing a resulting multi-layer pharmaceutical film|
|US9248050||Oct 11, 2012||Feb 2, 2016||Roar Consultants||Wound dressing garment|
|US9687454||Jan 6, 2016||Jun 27, 2017||Indivior Uk Limited||Sublingual and buccal film compositions|
|US20030107149 *||Feb 14, 2002||Jun 12, 2003||International Fluidics.||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20040234605 *||Nov 19, 2003||Nov 25, 2004||Cox David D.||Antimicrobial adhesive system|
|US20040258738 *||Jul 8, 2004||Dec 23, 2004||Kania Bruce G.||Treatment devices providing targeted antimicrobial action|
|US20040258896 *||Jan 30, 2004||Dec 23, 2004||Monosolrx Llc.||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20050184427 *||Mar 29, 2005||Aug 25, 2005||Monosolrx, Llc.||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20060039958 *||Sep 28, 2005||Feb 23, 2006||Monosolrx, Llc.||Multi-layer films having uniform content|
|US20060147493 *||Jul 22, 2003||Jul 6, 2006||Yang Robert K||Packaging and dispensing of rapid dissolve dosage form|
|US20070069416 *||Jun 22, 2006||Mar 29, 2007||Monosolrx, Llc||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20070122455 *||Sep 8, 2006||May 31, 2007||Monosolrx, Llc.||Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions|
|US20070149731 *||Dec 14, 2006||Jun 28, 2007||Monosolrx, Llc.||PH modulated films for delivery of actives|
|US20070154527 *||Dec 5, 2006||Jul 5, 2007||Monosoirx, Llc||Topical film compositions for delivery of actives|
|US20070172515 *||Jan 19, 2007||Jul 26, 2007||Monosolrx, Llc||Film bandage for mucosal administration of actives|
|US20070190157 *||Jan 19, 2007||Aug 16, 2007||Monosoirx, Llc.||Film lined packaging and method of making same|
|US20070281003 *||Feb 13, 2007||Dec 6, 2007||Fuisz Richard C||Polymer-Based Films and Drug Delivery Systems Made Therefrom|
|US20080044454 *||Jul 10, 2007||Feb 21, 2008||Monosolrx Llc||Uniform films for rapid dissolve dosage form incorporating taste-masking compositions|
|US20080075825 *||Sep 20, 2007||Mar 27, 2008||Fuisz Richard C||Edible Water-Soluble Film Containing a Foam Reducing Flavoring Agent|
|US20080078413 *||May 22, 2007||Apr 3, 2008||Padget David B||Surgical drape|
|US20080081071 *||Sep 28, 2007||Apr 3, 2008||Pradeep Sanghvi||Film Embedded Packaging and Method of Making Same|
|US20080220067 *||Jan 7, 2008||Sep 11, 2008||Cox David D||Antimicrobial adhesive system|
|US20080260805 *||Apr 14, 2008||Oct 23, 2008||Monosol Rx, Llc||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20080260809 *||Apr 22, 2008||Oct 23, 2008||Monosol Rx, Llc||Polyethylene oxide-based films and drug delivery systems made therefrom|
|US20090005443 *||Jun 20, 2008||Jan 1, 2009||Malcolm Philip Young||Treatment of Depression|
|US20090181069 *||Mar 26, 2009||Jul 16, 2009||Monosol Rx, Llc||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20100021526 *||Oct 7, 2009||Jan 28, 2010||Monosol Rx, Llc||Ph modulated films for delivery of actives|
|US20100227937 *||Feb 26, 2010||Sep 9, 2010||Cox David D||Antimicrobial adhesive system|
|US20110020217 *||Oct 10, 2008||Jan 27, 2011||E-Therapeutics Plc||Treatment of melanoma|
|US20110033376 *||Jul 4, 2008||Feb 10, 2011||Malcolm Philip Young||Treatment of Melanoma|
|US20110033541 *||Aug 7, 2009||Feb 10, 2011||Monosol Rx, Llc||Sublingual and buccal film compositions|
|US20110033542 *||Aug 7, 2009||Feb 10, 2011||Monosol Rx, Llc||Sublingual and buccal film compositions|
|US20110039906 *||Jul 18, 2008||Feb 17, 2011||E-Therapeutics Plc||Antibacterial combination therapy|
|US20110212173 *||Jun 17, 2009||Sep 1, 2011||e-Therapeutics Ple||Controlled Release Treatment of Depression|
|EP0044624A1 *||Jun 23, 1981||Jan 27, 1982||E.R. Squibb & Sons, Inc.||Lyophilized hydrocolloid foam|
|EP0159168A2 *||Apr 4, 1985||Oct 23, 1985||Takeda Chemical Industries, Ltd.||Soft patch drug preparation|
|EP0159168A3 *||Apr 4, 1985||Jan 8, 1986||Takeda Chemical Industries, Ltd.||Soft patch drug preparation|
|EP0161681A2 *||May 15, 1985||Nov 21, 1985||Mitsubishi Acetate Co., Ltd.||Gel plate and process for preparing same|
|EP0161681A3 *||May 15, 1985||Apr 29, 1987||Mitsubishi Acetate Co., Ltd.||Gel plate and process for preparing same|
|EP0167263A1 *||May 28, 1985||Jan 8, 1986||Matrix Pharmaceutical Inc.||Drug-containing matrices for introduction into cellular lesion areas|
|EP0177920A3 *||Oct 7, 1985||Jun 3, 1987||Teijin Limited||Pharmaceutical composition for external use containing active type vitam d3|
|EP0232580A2 *||Aug 21, 1986||Aug 19, 1987||Alza Corporation||Transdermal system II|
|EP0232580A3 *||Aug 21, 1986||Jun 21, 1989||Alza Corporation||Transdermal system ii|
|EP0297828A1 *||Jun 28, 1988||Jan 4, 1989||The Kendall Company||Novel medicated dressings|
|EP0438749A1 *||Dec 20, 1990||Jul 31, 1991||Beiersdorf Aktiengesellschaft||Self-adhesive mass from gelatine|
|EP0666081A1 *||Jan 20, 1995||Aug 9, 1995||Bristol-Myers Squibb Company||Wound dressing|
|EP0852148A1||Jan 7, 1997||Jul 8, 1998||Israel Fiber Institute||Products having anti-microbial activity|
|EP2014282A2||Jun 20, 2008||Jan 14, 2009||E-Therapeutics plc||Treatment of depression|
|EP2508231A2||Nov 15, 2007||Oct 10, 2012||E-Therapeutics Plc||Imidazoles for treating multi-drug resistant bacterial infections|
|EP2529733A1||Jul 18, 2008||Dec 5, 2012||E-Therapeutics Plc||Antibacterial combination therapy|
|EP2529737A1||Jul 18, 2008||Dec 5, 2012||E-Therapeutics plc||Antibacterial combination therapy|
|WO1993007928A1 *||Oct 23, 1992||Apr 29, 1993||Bioderm, Inc.||Medical apparatus fixation and infection control device|
|WO2009013480A2||Jul 18, 2008||Jan 29, 2009||E-Therapeutics Plc||Antibacterial combination therapy|
|WO2011030106A1||Sep 10, 2010||Mar 17, 2011||E-Therapeutics Plc||Cancer cell apoptosis|
|WO2012046006A2||Oct 7, 2011||Apr 12, 2012||University Of Dundee||Cancer targets|
|WO2012104589A1||Feb 2, 2012||Aug 9, 2012||University Of Edinburgh||Weight related disorders|
|WO2013160645A1||Apr 26, 2013||Oct 31, 2013||E-Therapeutics Plc||Dexanabinol or a derivative thereof for use in the treatment of cancer in dose ranges of 2-30 mg/kg|
|WO2013164561A1||May 3, 2013||Nov 7, 2013||E-Therapeutics Plc||Tramadol for treating depression|
|WO2015067746A1||Nov 7, 2014||May 14, 2015||Bsn Medical Gmbh||Medical dressing|
|WO2017068349A1||Oct 20, 2016||Apr 27, 2017||E-Therapeutics Plc||Cannabinoid for use in immunotherapy|
|U.S. Classification||604/304, 602/49, 433/180, 602/50|
|International Classification||A61K9/00, A61F13/00, A61F13/15, A61L15/58, A61L15/44|
|Cooperative Classification||A61F2013/00659, A61K9/006, A61L15/44, A61F2013/00472, A61F2013/53445, A61F13/122, A61L15/585, A61F13/0236, A61F13/8405, A61L2300/00, A61F13/00063|
|European Classification||A61L15/58M, A61K9/00M18D, A61L15/44, A61F13/00|