Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS3249109 A
Publication typeGrant
Publication dateMay 3, 1966
Filing dateNov 1, 1963
Priority dateNov 1, 1963
Publication numberUS 3249109 A, US 3249109A, US-A-3249109, US3249109 A, US3249109A
InventorsMaeth Harry, Pennings Ralph David
Original AssigneeMaeth Harry, Pennings Ralph David
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Topical dressing
US 3249109 A
Images(1)
Previous page
Next page
Description  (OCR text may contain errors)

Ma 3, 1966 H. MAETH ETAL 3,249,109

TORI CAL DRESS ING Filed Nov. 1, 1963 HARRY MA ETH R. DAVID PENNINGS BY Vndrus 9f Star/ 52 A'f-ronwsvs INVENTORS United States Patent 3,249,109 TOPICAL DRESSING Harry Maeth, 101 Main, and Ralph David Pennings, 302 Main, both of Mosinee, Wis. Filed Nov. 1, 1963, Ser. No. 320,809 9 Claims. (Cl. 128-268) This invention relates to a pharmaceutical preparation and more particularly to a pharmaceutical preparation for topical application to mucous membranes.

It is often desired to apply a dressing to the mucous membranes of the body, such as the oral cavity. For example, it may be desired to apply a post-operative dressing following gum surgery, or to use a dressing for intraoral traumatic wounds. In the past, dressings to be used in the oral cavity were generally made of tinfoil and included a base plate material which required heat to adapt it to its position on the membrane. If the dessing included a medicament or therapeutic agent, leakage of the agent generally occurred and could not be controlled. This resulted in the incomplete application of the agent to the site of treatment and dispersion of the agent into the mouth and possible entry into the alimentary tract.

The present invention is directed to an adhesive dressing to be topically applied to the body and in particular to the mucous membranes, such as the oral cavity. More specifically, the dressing or pharmaceutical preparation includes a flexible adhesive base composed of hydrated gelatin and including a small amount of pectin. In addition, a medicament or therapeutic agent can be incorporated in the flexible base. The base material is applied to the membrane at the site of the treatment and will adhere to the moist membrane. To prevent loss of the medicament or therapeutic agent, a backing member is applied to the outer surface of the flexible base. The backing member may take the form of a generally inert fabric, such as glass fibers, muslin or the like.

The hydrated gelatin base, which serves as the vehicle for the medicament or therapeutic agent, is flexible and is very adhesive and will readily adhere to the surfaces of the oral cavity or other mucous membranes. The gelatin base will remain flexible for extended periods of time and will not crack or chip. Moreover, the base does not contain oils or essential oils which can be irritating or toxic to the patient.

The use of the fabric backing layer insures theproper dosage of the medicament or therapeutic agent and prevents the dispersion of the agent from the site of treatment, thereby preventing the dispersion of the agent into the mouth and possible entry into the alimentary tract.

The pharmaceutical preparation or dressing can be used as a post-operative dressing in gum surgery, as a dressing for intraoral traumatic wounds, for the management of soft tissue lesions in the mouth, and as an irradiation shield for the treatment of malignant conditions with X-ray. In addition, it can also be used for topical application to the skin for abrasions, burns, varicose ulcers, and the like.

Other objects and advantages will appear in the course of the following description.

The drawings illustrate the best mode presently contemplated of carrying out the invention.

In the drawings:

FIG. 1 is a perspective view of a dressing prepared in accordance with the invention;

I FIG. 2 is a modified form of the invention showing the dressing in the form of a roll; and

FIG. 3 is a second modified form of the invention showing the dress-ing in the form of a pre-cut strip.

3,249,109 Patented May 3 1966 FIG. 1 shows a dressing 1 to be used for topical applications and particularly to the mucous membranes of the body. The dressing has particular application to the mucous membranes of the oral cavity, but also includes other areas such as the vagina, rectum, etc.

The dressing 1 includes a flexible hydrated gelatin base 2 and a fabric backing member 3. The hydrated gelatin base 2 contains by weight, 10 to 40% gelatin, 5 to Water, 15 to 80% polyhydric alcohol and up to 15% pectin.

The preferred range of composition, in weight percent is as follows:

Percent Gelatin 1033 Water 50-85 Polyhydric alcohol 15-35 Pectin 1-4 The hydrated gelatin gives the base its consistency and bulk and serves as the vehicle for the incorporation of medicaments and therapeutic agents.

Pectin is a carbohydrate obtained from the dilute acid extract of the inner portion of the rind of citrus fruits or apple peel. Pectin consists chiefly of partially methoxylated polygalacturonic acids.

The pectin provides adhesive properties to the hydrated gelatin and enables the gelatin base to be readily applied to moist surfaces, such as the mucous membranes.

The polyhydric alcohol serves to prevent brittleness and retains the flexible characteristics of the material for extended periods. The polyhdric alcohol can be glycerin, polyoxyethylene, propylene glycol, sorbitol, ethylene glycol (when used externally), and the like.

It is also contemplated that the base 2 will include a pharmacologically active material such as a medicament or a therapeutic agent. More specifically, the pharmacologically active material may include enzymes such as hyaluronidase; vasoconstrictors such as epinephrine; bactericides; bacteristatics; antacids; anesthetics; corticosteroids; antibiotics; hemostats; fluorides such as sodium fluoride, stannous fluoride, calcium fluoride; astringents, hormones; vitamins; tissue growth promoters such as Peruvian balsam; deodorants such as charcoal, and chlorophyll, and the like. The pharmacologically active material is used in an amount up to 10% by weight of the composition with the particular amount depending on the activity of the material.

The backing member 3 is formed of an inert, non toxic fibrous material such as glass fiber, muslin and the like. The use of glass fiber cloth has proven particularly satisfactory as a reinforcement and as a dam to reduce the spreading of the pharmacologically active material bility and a marked resistance to steam, corrosive fumes and most acids. In addition, the glass fiber will not absorb water and can be readily sterilized and re-sterilized and withstands repeated folding and creasing.

The fabric backing member 3 serves as a barrier and assures that the proper dosage of the medicament or therapeutic agent is supplied to the site to be treated. The backing member 3 prevents the agent from being dispersed into the mouth and prevents the entry of the agent into the alimentary tract.

To prepare the dressing of the invention, the gelatin and a portion of the Water and glycerin are mixed at an elevated temperature of about C. to form a gelatin component. ing portion of the water and glycerin to form a pectin component which is then added to the heated gelatin component. In some cases it may be desirable to add a The pectin is then mixed with the remainsmall amount, in the range of 1 to 2% of the total composition weight, of alcohol, such as ethyl alcohol, to the pectin component. The alcohol provides a rapid hydration of the pectin and can be omitted, but, if omitted, increases the time required for preparation.

After adding the pectin component to the gelatin component, the medicament or therapeutic agent is added as a solution or suspension, depending upon the particular agent used. The entire composition is then agitated to thoroughly mix the components and is subsequently poured into the desired mold and cooled. The backing member 3 is then overlayed onto the base material.

Example 1 As a specific example of the preparation, 30 grams of gelatin, 30 cc. of distilled water and 30 cc. of glycerin were mixed together and heated to a temperature of 90 C. to melt the gelatin. After the gelatin was melted, the pectin component consisting of 5 cc. of ethyl alcohol, 40 cc. of distilled water, cc. of glycerin and 5 grams of pectin was added to the liquid gelatin component and mixed therewith.

After adding the pectin component, 8 grams of Benzocaine and 40 cc. of alcohol, and 0.5 gram of Triburon (triclobisonium chloride) in 10 cc. of distilled water were added to the composition. After mixing in the Benzocaine and Triburon, the composition was poured into a mold and cooled. A glass fiber backing sheet was then overlayed over the composition and pressed firmly therein.

The resulting dressing was flexible and very adhesive and could readily be applied to mucous membranes.

Example 2 Three grams of pectin, 10 cc. of ethyl alcohol, 80 cc. of distilled water and 40 cc. of glycerin were mixed together. Forty grams of gelatin were added to this mixture and the entire composition heated to a temperature of 90 to 100 C. to melt the gelatin. Subsequently, 0.25

gram of Triburon in 17 cc. of glycerin and 20 cc. of distilled water were added to the gelatin-pectin composition. The resulting composition was then poured onto a suitable mold and cooled.

FIG. 2 shows a modified form of the invention in which the dressing is in strip form. In this embodiment the dressing includes a hydrated gelatin base 4 similar in composition to gelatin base 2 of the first embodiment. A fabric backing member 5 is applied to one surface of the base 4 and the backing member 5 is similar in structure and function to the backing member 3 of the first embodiment. In addition, a protective strip of material, such as waxed paper or other material, is applied to the outer surface of the barrier and serves to prevent the strip from sticking to itself when it is wound in spiral form.

The strip shown in FIG. 2 can be unwound as desired and cut to any length, depending on the nature of the site to be treated.

FIG. 3 shows a second modified form of the invention in which the dressing is in the form of a pre-cut strip. In this embodiment, the hydrated gelatin base 7, similar to base 2 of the first embodiment, is applied to an adhesive backing member 8. In this embodiment, a protective strip of material is applied to the adhesive surface of the strip 8 and can be removed immediately prior to application of the strip to the body surface.

The dressing of the invention is used for topical application, and particularly to the moist mucous membranes. For example, the dressing can be used as a post-operative dressing following surgery, as a dressing for traumatic wounds, 'as a dressing for soft tissue lesions and it also may be employed as an irradiation shield for the treatment of malignant conditions with X-ray. In this lattercase, a radiation barrier, such as powdered lead or barium sulphate, can be incorporated in the flexible base 2 in an amount of about 10 to 30% by weight of the base. The lead or barium sulphate is radiopaque material and serves as an irradiation shield to protect structures such as teeth and soft tissues from the radiation. This type of barrier is considerably more flexible and pliable than sheet lead for intraoral use, and being a lightweight material, is exceedingly more comfortable to the patient.

The dressing of the invention is flexible and will tightly adhere to moist membrane surfaces. If the dressing is to be applied to the external body tissues, it may be necessary to moisten the tissue before application.

It is contemplated that pharmacologically active materials can be incorporated in the hydrated gelatin base and the backing member serves to concentrate the activity of the material at the site of treatment and prevents the pharmacologically active material from dispersing outwardly into the mouth or other regions of the body.

Various modes of carrying out the invention are contemplated as being within the scope of the following claims particularly pointing out and distinctly claiming the subject matter which is regarded as the invention.

We claim:

1. A pressure sensitive dressing for topical application, comprising a solid, flexible hydrated gelatin base capable of maintaining its shape and containing a suflicient amount of pectin to provide initial adhesiveness for application to moist tissue and containing a sufiicient amount of a polyhydric alcohol to maintain flexibility for extended periods, and a generally inert non-toxic fibrous backing member disposed on one surface of said base and serving to prevent the outward dispersion of materials from the base.

2. A dressing for topical applications, comprising a solid, flexible, adhesive, film-like, hydrated gelatin base consisting essentially by weight of 10 to 40% gelatin, 5 to 85% water, 15 to of a polyhydric alcohol, and up to 15% pectin, and a fibrous backing member applied to one surface of the base, said backing member reinforcing the base and serving to prevent the outward dispersion of materials from the base.

3. The structure of claim 2, in which the hydrated gelatin base contains up to 10% by weight of a pharmacologically active material, said backing member serving to concentr-ate the pharmacologically active material at the site of treatment and preventing the outward dispersion of said material.

4. The structure of claim 2, in which the polyhydric alcohol is selected from the group consisting of glycerin, polyoxyethylene, propylene glycol, ethylene glycol, and sorbitol.

5. The structure of claim 3, in which the backing member is composed of glass fiber fabric.

6. A pressure sensitive dressing for topical applications, comprising a nonflow-able flexible, adhesive, hydrated gelatin sheet consisting essentially by weight of 10 to 33% gelatin, 50 to water, 1 to 4% pectin, 15 to 35% glycerin, and up to 10% of a pharmacologically active material, and a fabric backing member applied to one surface of the hydrated gelatin sheet, said backing member serving to concentrate the pharmacologically active material at the site of treatment and preventing the outward dispersion of said material.

7. The structure of claim 6 in which the hydrated gel-atin sheet also includes from 1 to 2% by weight of alcohol.

8. A dressing for topical applications, comprising a flexible, adhesive, hydrated gelatin base consisting essentially by weight of 10 to 40% gelatin, 5 to 85% Water, 15 to 80% of a polyhydric alcohol, up to 15% pectin and from 10 to 30% by weight of a material selected from the group consisting of lead and barium sulfate, and a fibrous backing member applied to one surface of the base, said backing member reinforcing the base and serving to prevent the outward dispersion of the material from the base, said material serving as a radiation shield to protect portions of the body from radiation.

9. A pressure sensitive article, comprising a flexible, adhesive, hydrated gelatin base containing up to 30% by weight of a radiopaque material, and a fabric backing member applied to one surface of the hydrated gelatin base, said backing member serving to concentrate the radiopaque material at the site of treatment and prevent the outward dispersion of said materiaL-said mtaerial serving as a radiation shield to protect portions of the article from radiation.

References Cited by the Examiner UNITED STATES PATENTS 307,537 11/1884 'Foulks 167 84 335,799 2/ 1886 Baby. 2,115,237 4/1938 Scholl 128268 X 6 Donaldson 1'28156 Shrontz 128-268 Reese.

Hirsch 106-125 Steinhardt 32--2 X FOREIGN PATENTS Germany.

OTHER REFERENCES Macleods Physiology in Modern Medicine, Bard, 8th edition, 1938.

ROBERT E. MORGAN, Primary Examiner.

15 RICHARD A. GAUDET, Examiner.

C. F. ROSENBAUM, Assistant Examiner.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US307537 *Nov 4, 1884 Dental capsicum-bag
US335799 *Oct 26, 1885Feb 9, 1886 Itnesses
US2115237 *May 11, 1936Apr 26, 1938Scholl William MMedicated button
US2450083 *Feb 7, 1944Sep 28, 1948Munising Paper CompanyTreated paper liner for adhesive rolls
US2501544 *Oct 23, 1946Mar 21, 1950Shellmar Products CorpTherapeutic product
US2583341 *Mar 21, 1950Jan 22, 1952Reese John DSkin graft receiving member
US2950980 *Sep 10, 1958Aug 30, 1960Arthur HirschAdhesive compositions
US3029187 *Feb 20, 1958Apr 10, 1962Amos SteinhardtGelating adhesive pharmaceutical preparations
*DE1074979B Title not available
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3329145 *Feb 12, 1965Jul 4, 1967Johnson & JohnsonSanitary napkin having control element with gel-forming material
US3339546 *Dec 13, 1963Sep 5, 1967Squibb & Sons IncBandage for adhering to moist surfaces
US3444858 *May 11, 1966May 20, 1969Higham S RussellMethod and means for administering drugs
US3598123 *Apr 1, 1969Aug 10, 1971Alza CorpBandage for administering drugs
US3688406 *Aug 7, 1970Sep 5, 1972Frank W HindsleyApparatus for and method of applying decay retardant compositions to teeth
US3696811 *Jun 17, 1971Oct 10, 1972Squibb & Sons IncPeriodontal bandage and backing therefor
US3769071 *Jun 4, 1971Oct 30, 1973Minnesota Mining & MfgPressure sensitive adhesive tape comprising 5-fluorouracil
US3960150 *Sep 15, 1975Jun 1, 1976Alza CorporationBioerodible ocular device
US3981303 *Jul 31, 1975Sep 21, 1976Alza CorporationBioerodible ocular device
US3986510 *Aug 1, 1975Oct 19, 1976Alza CorporationBioerodible ocular device
US3993071 *Jul 24, 1975Nov 23, 1976Alza CorporationBioerodible ocular device
US3993073 *Mar 3, 1975Nov 23, 1976Alza CorporationNovel drug delivery device
US3996934 *Aug 9, 1971Dec 14, 1976Alza CorporationMedical bandage
US3998215 *Apr 23, 1971Dec 21, 1976Minnesota Mining And Manufacturing CompanyBio-medical electrode conductive gel pads
US4022203 *Jan 22, 1976May 10, 1977Win AckleyTreated patch for minor cuts
US4062361 *Jul 7, 1975Dec 13, 1977Coloplast International A/SBilaminar ostomy sealing disc
US4239488 *Jun 15, 1979Dec 16, 1980Sempler Vance AEncapsulated denture adhesive and method of use
US4253460 *Jul 27, 1979Mar 3, 1981E. R. Squibb & Sons, Inc.Ostomy adhesive
US4265233 *Apr 6, 1979May 5, 1981Unitika Ltd.Material for wound healing
US4292299 *Jul 7, 1980Sep 29, 1981Teijin LimitedSlow-releasing medical preparation to be administered by adhering to a wet mucous surface
US4306551 *Jul 28, 1980Dec 22, 1981Lectec CorporationSterile improved bandage and sealant
US4307717 *Jul 28, 1980Dec 29, 1981Lectec CorporationSterile improved bandage containing a medicament
US4321252 *Dec 17, 1980Mar 23, 1982Key Pharmaceuticals, Inc.Polymeric diffusion matrix containing ester derivatives of estradiol
US4329333 *Nov 24, 1980May 11, 1982Arthur BarrMethod for the oral treatment of dogs and other animals
US4460562 *Mar 30, 1983Jul 17, 1984Key Pharmaceuticals, Inc.Polymeric diffusion matrix containing propranolol
US4470962 *Apr 28, 1981Sep 11, 1984Key Pharmaceuticals, Inc.Polyvinyl alcohol, polyvinylpyrrolidone, transdermal drugs
US4492685 *Jan 30, 1984Jan 8, 1985Key Pharmaceuticals, Inc.Portection of burned or wounded patients
US4631227 *Dec 5, 1983Dec 23, 1986Kenji NakamuraToilet article
US4655211 *Aug 8, 1985Apr 7, 1987Unitika Ltd.Hemostatic agent
US4695465 *Apr 5, 1985Sep 22, 1987Takeda Chemical Industry, Ltd.Soft patch
US4728323 *Jul 24, 1986Mar 1, 1988Minnesota Mining And Manufacturing CompanyAntimicrobial wound dressings
US4877618 *Mar 18, 1988Oct 31, 1989Reed Jr Fred DTransdermal drug delivery device
US4906475 *Feb 16, 1988Mar 6, 1990Paco Pharmaceutical ServicesEstradiol transdermal delivery system
US4984570 *Sep 14, 1989Jan 15, 1991Karl Otto Braun KgHydrophilic absorbent cellulosic layer
US4991574 *Aug 15, 1990Feb 12, 1991Dow Corning CorporationSurgical dressing
US5096715 *Nov 20, 1989Mar 17, 1992Alko Ltd.Containing a fixed dosage, a vehicle and permeation enhancer
US5207652 *Oct 23, 1991May 4, 1993BiodermMedical apparatus fixation and infection control device
US5234957 *Dec 23, 1991Aug 10, 1993Noven Pharmaceuticals, Inc.Compositions and methods for topical administration of pharmaceutically active agents
US5332576 *May 21, 1993Jul 26, 1994Noven Pharmaceuticals, Inc.Local anesthetic, solvent, bioadhesive carrier
US5336501 *Apr 29, 1992Aug 9, 1994Lohmann Gmbh & Co. KgCross-linked hydrogels and their use as wound dressings
US5437621 *Jan 12, 1993Aug 1, 1995Marmon Holdings, Inc.Medical dressing of a multilayered material
US5446070 *Aug 27, 1993Aug 29, 1995Nover Pharmaceuticals, Inc.Flexible, finite, bioadhesive, therapeutical agent in solid form
US5480377 *Feb 28, 1994Jan 2, 1996New Dimensions In Medicine, Inc.Wound dressing having a roll configuration
US5536263 *Mar 30, 1994Jul 16, 1996Lectec CorporationNon-occulusive adhesive patch for applying medication to the skin
US5741510 *Apr 8, 1996Apr 21, 1998Lectec CorporationTransdermal delivery
US5829442 *Jun 12, 1996Nov 3, 1998Medical Concepts Development, Inc.Antimicrobial containing solventless hot melt adhesive composition
US6016862 *Mar 10, 1999Jan 25, 2000Hormel Foods CorporationSand core
US6090915 *Oct 18, 1996Jul 18, 2000Hormel Foods CorporationCollagen or gelatin crumble composition and uses
US6096333 *Oct 8, 1997Aug 1, 2000Lectec CorporationMethod of forming adhesive patch for applying medication to the skin
US6096334 *Dec 14, 1998Aug 1, 2000Lectec CorporationSelf-supporting flexible sheet; fluid adhesive
US6469227May 12, 2000Oct 22, 2002Lectec CorporationAntipruritic patch
US6607746Jul 24, 2002Aug 19, 2003Medical Concepts Development, Inc.Antimicrobial containing solventless hot melt adhesive composition
US6664309Dec 7, 2000Dec 16, 2003Bostik Findley, Inc.Antimicrobial hot melt adhesive
US7087269Jun 22, 2001Aug 8, 2006Lg Chemical Co., Ltd.Multi-component composite membrane and method for preparing the same
US7157614Dec 21, 2001Jan 2, 2007Fountainhead, LlcLayer of polymeric gel block copolymer and mineral oil, and a second layer containing bactericidal silver metal in nylon fabric; dentistry, periodontal disease; appliances for mouth, nose, or other body cavity; bite blocks or plates, caps, braces
US7357891Jan 30, 2004Apr 15, 2008Monosol Rx, LlcProcess for making an ingestible film
US7425292Feb 14, 2002Sep 16, 2008Monosol Rx, LlcThin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7666337May 28, 2004Feb 23, 2010Monosol Rx, LlcPolyethylene oxide-based films and drug delivery systems made therefrom
US7824588Apr 14, 2008Nov 2, 2010Monosol Rx, LlcWater degradation; controlled drying; digestible film containing water soluble polymer
US7910641Dec 14, 2006Mar 22, 2011Monosol Rx, LlcPH modulated films for delivery of actives
US7972618Sep 20, 2007Jul 5, 2011Monosol Rx, LlcEdible water-soluble film containing a foam reducing flavoring agent
US8017150Apr 22, 2008Sep 13, 2011Monosol Rx, LlcPolyether combined with hydrophilic cellulosic material; demonstrates non-self-aggregating, uniform heterogeneity; mucosally adhesive water soluble product containing analgesic opiate; preventing air pocket formation during production
US8475832Aug 7, 2009Jul 2, 2013Rb Pharmaceuticals LimitedSublingual and buccal film compositions
US8603514Jul 10, 2007Dec 10, 2013Monosol Rx, LlcUniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8614179Jul 17, 2009Dec 24, 2013E-Therapeutics PlcAntibacterial combination therapy for the treatment of gram positive bacterial infections
US8652378Mar 29, 2013Feb 18, 2014Monosol Rx LlcUniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8663687May 13, 2010Mar 4, 2014Monosol Rx, LlcFilm compositions for delivery of actives
US8685437Mar 26, 2009Apr 1, 2014Monosol Rx, LlcThin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US8765167Sep 8, 2006Jul 1, 2014Monosol Rx, LlcUniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
EP0044624A1 *Jun 23, 1981Jan 27, 1982E.R. Squibb & Sons, Inc.Lyophilized hydrocolloid foam
EP0159168A2 *Apr 4, 1985Oct 23, 1985Takeda Chemical Industries, Ltd.Soft patch drug preparation
EP0161681A2 *May 15, 1985Nov 21, 1985Mitsubishi Acetate Co., Ltd.Gel plate and process for preparing same
EP0167263A1 *May 28, 1985Jan 8, 1986Matrix Pharmaceutical Inc.Drug-containing matrices for introduction into cellular lesion areas
EP0177920A2 *Oct 7, 1985Apr 16, 1986Teijin LimitedPharmaceutical composition for external use containing active type vitam D3
EP0232580A2 *Aug 21, 1986Aug 19, 1987Alza CorporationTransdermal system II
EP0297828A1 *Jun 28, 1988Jan 4, 1989The Kendall CompanyNovel medicated dressings
EP0438749A1 *Dec 20, 1990Jul 31, 1991Beiersdorf AktiengesellschaftSelf-adhesive mass from gelatine
EP0666081A1 *Jan 20, 1995Aug 9, 1995Bristol-Myers Squibb CompanyWound dressing
EP0852148A1Jan 7, 1997Jul 8, 1998Israel Fiber InstituteProducts having anti-microbial activity
EP2014282A2Jun 20, 2008Jan 14, 2009E-Therapeutics plcTreatment of depression
EP2508231A2Nov 15, 2007Oct 10, 2012E-Therapeutics PlcImidazoles for treating multi-drug resistant bacterial infections
EP2529733A1Jul 18, 2008Dec 5, 2012E-Therapeutics PlcAntibacterial combination therapy
EP2529737A1Jul 18, 2008Dec 5, 2012E-Therapeutics plcAntibacterial combination therapy
WO1993007928A1 *Oct 23, 1992Apr 29, 1993Bioderm IncMedical apparatus fixation and infection control device
WO2009013480A2Jul 18, 2008Jan 29, 2009E Therapeutics PlcAntibacterial combination therapy
WO2011030106A1Sep 10, 2010Mar 17, 2011E-Therapeutics PlcCancer cell apoptosis
WO2012046006A2Oct 7, 2011Apr 12, 2012University Of DundeeCancer targets
WO2012104589A1Feb 2, 2012Aug 9, 2012University Of EdinburghWeight related disorders
WO2013160645A1Apr 26, 2013Oct 31, 2013E-Therapeutics PlcDexanabinol or a derivative thereof for use in the treatment of cancer in dose ranges of 2-30 mg/kg
WO2013164561A1May 3, 2013Nov 7, 2013E-Therapeutics PlcTramadol for treating depression
Classifications
U.S. Classification604/304, 602/49, 433/180, 602/50
International ClassificationA61K9/00, A61F13/00, A61F13/15, A61L15/58, A61L15/44
Cooperative ClassificationA61F2013/00659, A61K9/006, A61L15/44, A61F2013/00472, A61F2013/53445, A61F13/122, A61L15/585, A61F13/0236, A61F13/8405, A61L2300/00, A61F13/00063
European ClassificationA61L15/58M, A61K9/00M18D, A61L15/44, A61F13/00