Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.


  1. Advanced Patent Search
Publication numberUS3308818 A
Publication typeGrant
Publication dateMar 14, 1967
Filing dateJul 24, 1964
Priority dateJul 24, 1964
Publication numberUS 3308818 A, US 3308818A, US-A-3308818, US3308818 A, US3308818A
InventorsRutkowski Eugene V
Original AssigneeRutkowski Eugene V
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Injection cartridge
US 3308818 A
Abstract  available in
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

March 1967 E. v. RUTKOWSKI INJECTION CARTRIDGE Filed July 24, 1964 A W R 2 0m E KE LO V L 6 N U l R] A F M V O 2 E N as E G W G C2 w m F x W FIG.



United States Patent 3,308,818 INJECTION CARTRIDGE Eugene V. Rutkowski, 1010 Esplanade, Apt. 17, Redondo Beach, Calif., 90277 Filed July 24, 1964, Ser. No. 385,092 Claims. (Cl. 128-173) The invention described herein may be manufactured and use-d by or for the Government of the United States of America for governmental purposes without the payment of any royalties thereon or therefor.

This inventionrelates to improvements in apparatus for effecting subcutaneous and intramuscular injections of medicaments and the like into human beings and animals, and more particularly to improvements for injection without the use of 'a hypodermic needle.

A. recent technique has evolved for subcutaneous injections without the use of a hypodermic needle in which a metered quantity of injectant is projected against the skin at such high pressure and velocity that it penetrates the skin. Such technique is exemplified by the multi-dose injector, manufactured by the R. P. Sherer Company of Detroit, Mich. Such device is quite complicated and expensive and requires an electric motor source for developing the requisite pressure for the injectant gun. In remote regions, where a source of electric power is not available, it therefore becomes unusable. Also, because of its considerable bulk and weight it presents transportation difficulties into such regions.

One of the objects of this invention is to provide a needleless injection device which contains a potential source of gas pressure which may be activated, when desired, and without any specialized power operated apparatus.

Another object is to provide a disposable device of such type for injecting a single metered dose.

A further object is to provide a disposable device of such type which may be constructed so economically that it can be made available to a greater number of users in need of the same.

Still further objects, advantages and salient features will become more apparent from the description to follow, the appended claims and the accompanying drawing in which:

FIG. 1 is an enlarged central section through one form of the invention;

FIGS. 1A and 1B are like sections illustrating various stages of operation;

FIG. 2 is a like section through another form of the invention;

FIG. 2A is a like section of FIG. 2 illustrating the final stage of operation;

FIG. 3 illustrates a modified type of igniter, and

FIG. 4 illustrates a gun which may be optionally employed with any of the various forms of the invention.

Referring now to the drawing, and particularly to FIG. 1, the subject of the invention, in one of its forms, comprises a cylindrical capsule or tube closed at one end by a closure 12 and in which is housed a spherical container 14 which is filled with the desired injectant fluid 16. A head or cap member 18 sealingly closes the opposite end of the capsule to prevent leakage of high pressure gas. The cap may thre-adedly engage the tube, as shown, or otherwise be sealingly secured to it such as by deforming the upper edge of the tube, as by rolling, over the upper edge of the cap. As will be apparent, cements, solders and the like may be employed to sealingly bond the cap to the tube.

A predetermined quantity of propellant powder 20 is disposed within the cylindrical capsule or tube 10, which 3,308,818 Patented Mar. 14, 1967 upon igniting, will produce a predetermined gas pressure within the capsule. Ignition of the propellant may be efiected by a conventional squib 22 containing a bridge wire (not shown) which is energized by electric current from a small portable battery, such as a flash light battery, through a suitable electric lead 24.

The head or cap member is provided with an aperture 25 which leaves a small area of the spherical container wall unsupported and into which the wall may rupture when the injectant container is pressurized. This aperture communicates with a small discharge orifice 26 through which the injectant is expelled at extremely high velocity, sufiicient to effect subcutaneous or intra-muscular penetration of the injectant.

FIG. 1A illustrates the deformation of the injectant container shortly after ignition of the squib at which time the wall has ruptured into aperture 25 and the fluid is being expelled through orifice 26 at high velocity. FIG. 18 illustrates complete deformation or retroversion of the container in which the lower half of the spherical wall has engaged the upper half and the volume of the container has been reduced to its minimum.

The injectant container may be constructed of any material, such as metal or plastic, which is sufliciently ductile to deform, as illustrated, yet not rupture to permit entry of the high pressure gas into the container. In some instances it may be desirable to dispose a ductile heat shield at least adjacent the lower portion of the container to prevent excessive heat transmission to the container wall which might cause rupture by melting or other high temperature failure.

FIG. 2 illustrates a modified form of injectant container 14A which is dome-shaped at one end,-as in the previous embodiment, but is otherwise cylindrical in shape. FIG. 2A illustrates the complete deformation of this container after being pressurized.

FIG. 3 illustrates another form of igriiter in the form of a percussion cap 22A which may be initiated by impact of a firing pin 30.

FIG. 4 is exemplary of a gun" 32 containing an injectant cartridge. Any suitable movable closure 34 may be employed to permit insertion of the cartridge into the gun after which it may be initiated by a trigger 36 which may operate a hammer for the percussion type or operate a switch for the electric squib type. The battery may cOnveniently be housed within the handle of the gun.

Obviously many modifications and variations of the present invention are possible in the light of the above teachings. It is therefore to be understood that within the scope of the appended claims the invention may be practiced otherwise than as specifically described.

What is claimed is:

1. Apparatus for subcutaneous injections of liquid medicaments and the like, comprising;

(a) an outer container adapted to withstand high gas pressure,

(b) a hermetically sealed ductile inner container, containing the medicament,

(c) said inner container having a first portion of its wall supported by said outer container and a second portion adapted to deform into a retroversion contact with the first portion, without rupturing, to thereby reduce its volume to zero,

(d) said first portion of the inner container being unsupported by the outer container over a relatively small area to permit the inner container to rupture,

(e) a nozzle in the outer container communicating with said area through which the medicament may be discharged at a sufiiciently high velocity to eifect subcutaneous injection,

3 (f) a powder type propellant in said first container, the

products of combustion of which are adapted to deform said inner container, and

(g) means for initiating combustion of said propellant.

2. Apparatus in accordance with claim 1 wherein said second container is spherical in shape with a first hemispherical portion supported by said first container and a second hemispherical portion unsupported and adapted to be deformed concavely hemispherical and into contact with the first hemispherical portion.

3. Apparatus in accordance with claim 1 wherein said second container is cylindrical in shape with an unsupported end wall adapted to be deformed concavely and into contact with the supported portion.

4. Apparatus in accordance with claim 1 wherein the means for initiating combustion of said propellant comprises an electrically initiated squib.

5. Apparatus in accordance with claim 1 wherein the means for initiating combustion of said propellant comprises a percussion cap.

References Cited by the Examiner UNITED STATES PATENTS 1,642,950 9/1927 Haas 128265 5 2,151,418 3/1939 Bolte 128265 2,816,544 12/1957 Scherer et al 128-173 3,071,294 1/1963 Galbierz 222541 3,145,712 8/1964 Litz 128173 10 References Cited by the Applicant UNITED STATES PATENTS 2,674,998 4/1954 Boehm.

2,854,925 10/1958 Crockford et al.

2,876,771 3/ 1959 Dunmire. 15 3,023,750 3/1962 Baron.

FOREIGN PATENTS 1,121,237 4/1956 France.

20 RICHARD A. GAUDET, Primary Examiner.

K. L. HOWELL, Assistant Examiner.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US1642950 *Feb 24, 1927Sep 20, 1927Haas Earle CMedical-powder applicator
US2151418 *May 12, 1937Mar 21, 1939Scott & BownePowder applicator
US2674998 *Aug 25, 1950Apr 13, 1954Georg BoehmSyringe for gas injections
US2816544 *Jul 12, 1954Dec 17, 1957Scherer Corp R PHypodermic injector
US2854925 *Jul 23, 1957Oct 7, 1958Palmer Chemical & Equipment CoProjectile for delivery of drugs to animals
US2876771 *Nov 30, 1954Mar 10, 1959Dunmire Russell PaulHypodermic syringes
US3023750 *Mar 4, 1959Mar 6, 1962Howard C BaronSelf-generating pressure device for infusion administration systems
US3071294 *Apr 3, 1961Jan 1, 1963R C Can CoDispensing device for caulking cartridges
US3145712 *Mar 13, 1963Aug 25, 1964Litz Jr Charles JPercutaneous medication device
FR1121237A * Title not available
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3415277 *Mar 20, 1967Dec 10, 1968Thiokol Chemical CorpUllage control
US3483695 *Apr 25, 1967Dec 16, 1969Charles R OlsenActuator
US3802430 *Jun 30, 1972Apr 9, 1974Arnold LDisposable pyrotechnically powered injector
US3810655 *Aug 21, 1972May 14, 1974Gen Motors CorpGas generator with liquid phase cooling
US4007691 *Dec 23, 1975Feb 15, 1977The United States Of America As Represented By The Secretary Of The NavySmoke marker
US4169403 *Aug 4, 1978Oct 2, 1979Hanson Ralph WBomb circuit disrupting device and method
US4564363 *Jul 13, 1983Jan 14, 1986Smithkline Beckman CorporationDelayed action assembly
US5026343 *Nov 17, 1989Jun 25, 1991Walter HolzerDevice for needleless hypodermic injection of medications
US5062834 *Aug 15, 1989Nov 5, 1991Product Development (S.G.Z.) LtdDevice for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate
US5346473 *Feb 22, 1993Sep 13, 1994The United States Of America As Represented By The Department Of Health And Human ServicesOxy-hydrogen propelled torpedo for introducing angioplasty guide wire
US5421263 *Mar 24, 1994Jun 6, 1995Raikka OyCartridge for spraying a liquid into the barrel of a firearm
US5425706 *Feb 14, 1990Jun 20, 1995S. I. Scientific Innovations Ltd.Dispensing device particularly useful for dispensing nutritional liquids
US5599302 *Jan 9, 1995Feb 4, 1997Medi-Ject CorporationMedical injection system and method, gas spring thereof and launching device using gas spring
US5643211 *Feb 29, 1996Jul 1, 1997Medi-Ject CorporationNozzle assembly having a frangible plunger
US5697917 *Feb 29, 1996Dec 16, 1997Medi-Ject CorporationNozzle assembly with adjustable plunger travel gap
US5722953 *Feb 29, 1996Mar 3, 1998Medi-Ject CorporationNozzle assembly for injection device
US5800388 *Feb 29, 1996Sep 1, 1998Medi-Ject CorporationPlunger/ram assembly adapted for a fluid injector
US5846233 *Jan 9, 1997Dec 8, 1998Medi-Ject CorporationCoupling device for medical injection system
US5865795 *Feb 29, 1996Feb 2, 1999Medi-Ject CorporationSafety mechanism for injection devices
US5875976 *Dec 24, 1996Mar 2, 1999Medi-Ject CorporationLocking mechanism for nozzle assembly
US5877390 *Dec 17, 1996Mar 2, 1999Canon Kabushiki KaishaUsing gas pressure
US5891085 *Jan 9, 1997Apr 6, 1999Medi-Ject CorporationNozzle assembly with lost motion connection for medical injector assembly
US5919159 *Jan 9, 1997Jul 6, 1999Medi-Ject CorporationMedical injection system and method, gas spring thereof and launching device using gas spring
US5921967 *Dec 24, 1996Jul 13, 1999Medi-Ject CorporationPlunger for nozzle assembly
US5947928 *Jun 19, 1997Sep 7, 1999Mile Creek Capital, LlcDrug delivery system
US6258063Jan 16, 1998Jul 10, 2001Roche Diagnostics GmbhHypodermic injection system
US6270473Mar 15, 1996Aug 7, 2001Jettek, Inc.Hypodermic jet injector and disposable ampule
US6537245Oct 6, 2000Mar 25, 2003Crossject CompanyNeedleless syringe with a friction activated pyrotechnic initiator
US6592545Mar 15, 1999Jul 15, 2003Powderject Research LimitedParticle delivery
US6685669 *Dec 21, 1995Feb 3, 2004Powderject Research LimitedParticle delivery
US6726665Sep 13, 1999Apr 27, 2004Pharmacia AktiebolagOcular treatment device
US7160265Jun 20, 2001Jan 9, 2007Peter LellNeedleless injection device with pyrotechnic drive
US7455655 *Mar 18, 2004Nov 25, 2008CrossjectNeedleless injection device comprising means for regulating the gas pressure level in the combustion chamber
US7806867Sep 8, 2003Oct 5, 2010Valeritas, Inc.Injection device
US7909793Jul 25, 2002Mar 22, 2011Powderject Research LimitedSilencing device and method for needleless syringe
US8221347Dec 1, 2005Jul 17, 2012Acushot, Inc.Needle-free injector
US8651340 *Aug 11, 2010Feb 18, 2014Koninklijke Philips N.V.Fluid reservoir for a handheld device for personal care
US8794487 *Jul 8, 2010Aug 5, 2014Dispensing Technologies B.V.Composite container and method for manufacturing same (“multi-layer preform”)
US20120167393 *Aug 11, 2010Jul 5, 2012Koninklijke Philips Electronics N.V.Fluid reservoir for a handheld device for personal care
USRE28434 *Dec 13, 1971May 27, 1975 Olsen actuator
DE10057931A1 *Nov 22, 2000Aug 29, 2002Peter LellPyrotechnisch betriebenes chirurgisches Instrument (Pyronadel)
DE10057931B4 *Nov 22, 2000Nov 8, 2007Lell, Peter, Dr.-Ing.Pyrotechnisch betriebenes chirurgisches Instrument (Pyronadel)
EP0853952A1 *Feb 1, 1997Jul 22, 1998Boehringer Mannheim GmbhTransdermal injection device
EP1090651A1 *Sep 20, 2000Apr 11, 2001Cross Site TechnologiesNeedleless syringe supplied with a trigger activated by friction
EP1512425A2Jan 16, 1998Mar 9, 2005Roche Diagnostics GmbHHypodermic Injection System
EP1637174A2 *Jul 25, 2002Mar 22, 2006PowderJect Research LimitedSilencing device and method of operating a needleless syringe
EP1707228A1 *Jan 10, 2006Oct 4, 2006Laar Kurt Daniel VanPatch with needleless injection systems
EP1847286A2 *Jul 25, 2002Oct 24, 2007PowderJect Research LimitedSilencing device and method of operating a needleless syringe
WO1996020022A1 *Dec 21, 1995Jul 4, 1996John BellParticle delivery
WO1998031409A2 *Jan 16, 1998Jul 23, 1998Manfred BeuttenmuellerHypodermic injection system
WO2001097880A2Jun 20, 2001Dec 27, 2001Peter LellNeedleless injection device with pyrotechnic drive
WO2003011380A2 *Jul 25, 2002Feb 13, 2003Mark Anthony Fernance KendallSilencing device and method for needleless syringe
WO2003051432A1 *Dec 4, 2002Jun 26, 2003Roche Diagnostics GmbhNeedleless hypodermic injection device
U.S. Classification604/69, 102/512, 222/95, 222/386.5, 604/403, 604/72
International ClassificationA61M5/20, F42B12/54, A61M5/24, F42B12/02, A61M5/30, A61M5/28
Cooperative ClassificationA61M5/2425, F42B12/54, A61M5/286, A61M5/30, A61M5/2046
European ClassificationF42B12/54, A61M5/30