|Publication number||US3313439 A|
|Publication date||Apr 11, 1967|
|Filing date||Dec 17, 1965|
|Priority date||Dec 22, 1964|
|Publication number||US 3313439 A, US 3313439A, US-A-3313439, US3313439 A, US3313439A|
|Original Assignee||Allen & Hanburys Ltd|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (2), Referenced by (15), Classifications (7)|
|External Links: USPTO, USPTO Assignment, Espacenet|
13 m 31, 1967 ROBINSON 3,313,433
CLOSURES FOR CONTAINERS Filed Dec. 17, 1965 3 Sheets-Sheet 2 INVENTOR JAMES ROBINSON ATTORNEYS Aprfl 11, 1967 J, ROBINSON 3,313,439
CLOSURES FOR CONTAINERS Filed Dec. 17, 1965 3 Sheets-Sheet 3 V j i 5 k 5 E\ 2 y fi 28 \g so IN VENTOR JAME ROBINSON ATTORNEYS United States Patent 3,313,439 CLOSURES FOR CONTAINERS James Robinson, London, England, assignor to Mien and Hanbnrys Limited, London, England, a British company Filed Dec. 17, 1965, Ser. No. 514,590
Claims priority, application Great Britain, Dec. 22, 1964,
52,115/64 4 Claims. (Cl. 21537) This invention relates to closures for containers and particularly, but not exclusively, to closures for containers such as bottles used for administering parenteral solutions.
Parenteral solutions must be maintained in a completely sterile condition. It is therefore necessary to keep them in containers having closures which provide a completely hermetic seal. The closures of such containers are usually made of rubber, which is the best known sealing material for producing a sterile seal, and usually have passages leading to the interior of the container. At least two such passages are normally provided, one being arranged to receive a delivery tube for discharging the contents of the container with the other being arranged to receive an air inlet tube extending almost to the bottom of the bottle. The external openings of the passages are sealed until the contents of the container are used in order to maintain the contents in a sterile condition. Various seals have been employed in the past. For example, the outer surface of a rubber closure has been covered by a flexible rubber sealing disc or the passages may be closed by removable plugs or the passages may not extend through the entire closure, the remaining portion of the closure being penetrable by a hollow needle of, for example, the delivery tube.
Such closures have all suffered from the disadvantage that the contents of the containers may become contaminated with particulate, colloidal or soluble extractial material from the rubber closure during sterilisation and when maintained over long periods of time after sterilisation. Various attempts have been made to overcome this difiiculty. For example, it has been proposed to cover the surface of the closure in contact with the contents of the bottle with lacquer or to modify the surface by treatment with halogen. Such a modified surface can, if desired, be coated with nylon. None of these proposals is entirely satisfactory since the barriers between the closure and the solution are not completely impervious or the barriers are time-consuming and costly to apply.
It is an object of the present invention to provide a closure for parenteral solution bottles which does not suffer from these disadvantages, but retains the high etficiency 0f the sealing properties of rubber.
Accordingly the present invention provides a closure for a container comprising, a stopper made of resilient material adapted to be tightly seated in the neck of the container and having at least one passage extending completely through the closure in the axial direction thereof and a protective cap of inert material fitted on the internal surface of the stopper so as to prevent the stopper coming into contact with the contents of the container, the said cap having a pierceable protuberance fitted in, and closing, the passage or each passage.
The stopper is preferably of rubber. The protective cap is preferably of a thermoplastic material which is resistant to sterilization temperatures; examples of suitable materials are polypropylene or high density polyethylene. The cap may be a moulding and may be fitted on the internal surface of the stopper before the latter is inserted in the neck of the container.
It is important that the cap is firmly secured to the stopper especially if the container is under vacuum as the cap will then tend to be forced into the container. The
protuberance, or each of them, grips the sidewalls of the passage and provide a good seal between the cap and the stopper. The protuberance or each of them may be enlanged at the outer end and the enlarged portion may fit tightly into a corresponding recess in a passage. When the pressure outside the container is greater than that inside, the enlarged portion of a protuberance is forced against the walls of the recess thereby efiecti-vely sealing the passageways. The pressure created when the closure is compressed by insertion into the neck of the container also forces the cap firmly on to the stopper and the effect of the sterilisation temperature on the thermoplastic material of the cap produces intimate contact, and possibly some bonding together, of the cap and the stopper.
In the accompanying drawings:
FIG. 1 is a plan view of the upper surface of the closure,
FIG. 2 is a sectional view of the closure of line AA,
FIG. 3 is a partial sectional view similar to FIGURE 2 but on line BB,
FIG. 4 is sectional view corresponding to FIG. 2 howing the closure fitted in the neck of the container,
FIGURE 5 is a view similar to FIGURE 2 but of a modified closure, and
FIGURE 6 is a sectional view of the same closure taken on line C-C.
FIGURES 1 to 4 of the drawings illustrate a closure comprising a rubber stopper 1 having a flange 2 which fits over the rim of the neck of a bottle 3 and a spigot portion 4 which fits inside the neck. The stopper 1 has two passages 5 and 6 extending through the stopper in the axial direction thereof towards the interior of the neck. The passage 5 is intended to receive and grip a delivery tube when the bottle is to be emptied and the passage 6 is arranged to receive at its inner end an air-inlet tube 7 which extends almost to the bottom of the bottle 3. The passages 5 and 6 have enlarged recesses 8 and 9 respectively.
The stopper has a portion 10 of reduced thickness provided by blind passages 11 and 12. A hollow needle for the introduction of additional medicament may be inserted into the bottle through the reduced portion 10.
A cap 13 is fitted to the inner surface of the stopper 1. This cap 13 is made of, for example, polypropylene or high density polyethylene. The cap 13 has a wall or skirt 14 which covers most of the walls of the spigot 4, a small region 15 of the spigot wall near the rim of the neck being not covered so as to provide a good seal with the portion of the neck in'contact with it.
The skirt 14 may have a circular beading around its outermost edge and this beading may fit into a complementary groove in the stopper. This also helps to secure the cap 13 to the stopper 1.
The cap 13 has protuberances 16, 17 and 18 which enter and close passageways 5, 6 and 12 respectively and extend to a position intermediate the ends of the passageways. The protuberances 16 and 17 have enlarged portions 19 and 20 which engage with the recesses 8 and 9 of passageways 5 and 6.
The external surface of the closure may have a dustcover such as a thin rubber diaphragm held in place by a tear-01f cap made of, for example, aluminium.
When it is desired to administer the contents of the bottle, the tear-off cap and the dust-cover are removed to expose the ends of the enlarged portions, 19 and 20, of the protuberances, 16 and 17, in the passages 5 and 6. If the delivery tube has a plastic needle this may be pushed through the portion 19 while a plastic or metal air-inlet needle may be similarly inserted through the protuberance 17 into the air-inlet tube 7. If the delivery tube is made of glass the protuberances 16 and 17 are pierced with, for example, a hollow needle and the delivery tube is then inserted in the broken protuberance 16. The hollow needle used for piercing the protuberances may, if desired be left in the air-inlet hole 6.
FIGURES 5 and 6 illustrate a modified closure which is used in the same way as that of FIGURES 1 to 4 and includes a rubber stopper 21 basically the same as the stopper 1. Extending through this stopper, are passages 22, 23 and 24, each of these passages having reduced outer portions of which only the portions 25 and 26 of the passages 22 and 23 are visible in the drawings. A cap 27 of polypropylene has a skirt 28 fitting on the outside of the stopper 21 and protuberances 29, 30 and 31 tightly fitting in the passages 22, 23 and 24 respectively. These protuberances differ from the corresponding ones (16, 17 and 18) of the embodiment of FIGURES 1 to 4 in that they do' not have enlarged portions. The protuberance 30 is of larger diameter than the others and has a closure end surface 32 which is concave or dished towards the interior of the protuberance. This assists in ensuring that a needle pushed through this end will pierce the centre of the end surface.
If desired, the protuberances of both embodiments can be of such a length that they will, when the closure is fitted in the neck of a bottle, extend above the level of the rim of the neck. This will increase the area of the cap gripped by the rubber of the stopper when the rubber is compressed by the insertion of the stopper into a bottle neck.
A tight grip between the cap and the stopper can also be assisted by providing the protuberances with one or more annular beads.
What is claimed is:
1. A closure for a container which closure comprises a stopper made of resilient material so that it can be tightly seated in a neck of said container and having a passage extending completely through the closure in the axial direction thereof; and a protective cap of inert material fitted on the internal surface of said stopper so as to prevent said stopper coming into contact with the contents of the container, said cap having a pierceable protuberance fitted in, and closing, said passage.
2. In a neck of a container for liquids, a closure comprising a rubber stopper which is tightly seated in said neck and has a plurality of passages extending completely therethrough in the axial direction thereof; and a protective cap of an inert material fitted to the internal surface of said stopper so as to prevent said stopper coming into contact with the contents of said container, said cap having a plurality of pierceable protuberances each of which is fitted in, and closes, one of said passages.
3. A bottle closure comprising a stopper of resilient material with a spigot adapted to fit in a bottle neck and a flange adapted to fit over the rim of said neck, said stopper having a plurality of passages therethrough; and a cap of inert material with a skirt extending over part of the surface of said spigot and a plurality of pierceable protuberances each of which fits in, and closes, one of said passages, each of said protuberances extending to a position intermediate the ends of the passage in which his located.
4. In a container having a neck, a closure comprising a resilient stopper with a spigot fitted in said neck and a flange fitted on the rim of said neck, said stopper havinga plurality of passages extending therethrough to provide access to the interior of said container; and a cap of inert material with a skirt extending over part of the surface of said spigot and a plurality of pierceable protuberances each of which fits in and closes one of said passages, said protuberances having annular bulges intermediate their ends.
References Cited by the Examiner UNITED STATES PATENTS 3/1937 Baxter. 5/1956 Hartop et al. 215-4
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2072853 *||Dec 1, 1934||Mar 9, 1937||Donald E Baxter||Closure|
|US2747756 *||Jul 10, 1952||May 29, 1956||Abbott Lab||Rubber closure|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3904060 *||Feb 26, 1974||Sep 9, 1975||American Hospital Supply Corp||Three barrier closure system for medical liquid container|
|US3974930 *||Apr 9, 1975||Aug 17, 1976||Becton, Dickinson And Company||Stopper for specimen container|
|US4554125 *||Mar 17, 1983||Nov 19, 1985||Schering Corporation||Method of making a stopper for a sterile fluid container|
|US4635807 *||Sep 3, 1985||Jan 13, 1987||Schering Corporation||Stopper for sterile fluid containers|
|US5130255 *||Dec 13, 1990||Jul 14, 1992||Genentech, Inc.||Process for preparing storage stable pharmaceuticals|
|US5232109 *||Jun 2, 1992||Aug 3, 1993||Sterling Winthrop Inc.||Double-seal stopper for parenteral bottle|
|US5279606 *||Aug 28, 1991||Jan 18, 1994||Habley Medical Technology Corporation||Non-reactive composite sealing barrier|
|US5364384 *||Jun 14, 1993||Nov 15, 1994||Abbott Laboratories||Flexible container with intergral protective cover|
|US5598939 *||Aug 18, 1995||Feb 4, 1997||Watson; Thomas L.||Bottle with closure element for receiving syringe and method therefor|
|US20120067887 *||Dec 14, 2009||Mar 22, 2012||Heipha Gmbh||Container having septum closure and closing cap having a septum closure|
|US20140345368 *||May 21, 2013||Nov 27, 2014||Hach Company||Dripless, permanent sealing assembly for container|
|USRE35167 *||Nov 2, 1992||Mar 5, 1996||Mouchawar; Marvin L.||Medicine vial cap for needleless syringe|
|DE3310265A1 *||Mar 22, 1983||Sep 27, 1984||Gerhard Hansen||Aufreissverschluss fuer einen behaelter|
|WO1984000103A1 *||May 2, 1983||Jan 19, 1984||Baxter Travenol Lab||Dome seal for container ports|
|WO1993004951A1 *||Aug 25, 1992||Mar 18, 1993||Habley Medical Technology Corp||Non-reactive composite sealing barrier|
|U.S. Classification||215/247, 215/DIG.300, 604/415|
|Cooperative Classification||B65D51/002, Y10S215/03|