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Publication numberUS3320952 A
Publication typeGrant
Publication dateMay 23, 1967
Filing dateNov 13, 1964
Priority dateNov 22, 1963
Also published asDE1491707A1, DE1491707B2, DE1491707C3
Publication numberUS 3320952 A, US 3320952A, US-A-3320952, US3320952 A, US3320952A
InventorsFrank Wright
Original AssigneeFisons Pharmaceuticals Ltd
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Nasal applicators
US 3320952 A
Abstract  available in
Images(2)
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Claims  available in
Description  (OCR text may contain errors)

May 23, 1967 F. WRIGHT NASAL APPLICATORS 2 Sheets-Sheet 1 Filed Nov. 13, 1964 IN VEN TOR. Frank Wright ATTOR N 5Y5 May 3, 1967 F WRIGHT 3,320,952

NASAL APPLICATORS Filed Nov. 13, 1964 f 2 Sheets-Sheet 2 /0 l I! l /0 I l I l o W 4 /3 L ,1 4 /3 2 H /2 l2 F r 3 W k w 3 3 Y 5 H6 5 M I J /4 FIG 6 4 y 5K5 4 2 i- H h Ml H 3 :\I'-' 12"? /4 3/ L' INVENTOR. f Frank Wright BY MM,M Q ATTORNEYS United States Patent Ofifice 3 ,320,952 Patented May 23, 1967 3,320,952 NASAL APPLICATGRS Frank Wright, Rurlheath, Northwich, England, assignor to Fisons Pharmaceuticals Limited, Loughhorough, Leicestershire, England Filed Nov. 13, 1964, Ser. No. 410,917 Claims priority, application Great Britain, Nov. 22, 1963,

3 Claims. (Cl. 128173) This invention is concerned with improvements in or relating to applicators for the application of medicaments by nasal inhalation.

A number of medicaments may be administered by nasal application. Thus, medicaments intended for nasal application are often of the decongestant type intended to relieve congestion in the upper part of the nose and in the sinuses. Other drugs which may be applied by nasal inhalation are those intended to relieve inflammation in the upper nose and in the sinuses. Drugs for systemic action can also be administered by this route.

Such medicaments are normally applied in liquid form by means of a short rigid tube of glass or other thermoplastic material which is inserted into the nostril, the medicament being forced through the tube by the action of a compressible rubber bulb or like means. Such devices are, in general, inefiicient in supplying the medicament in uniform dosages and are, therefore, not suitable for the clinical application of medicaments by nasal inhalation. Further, such devices generally supply the liquid in the form of thin stream or as a stream of relatively large droplets with consequent inefficiency in absorption.

of the medicament.

It has been found convenient to apply medicaments for nasal inhalation by means of pressurised packs; i.e., by dispersing the medicament in a propellant in a pressurised container, the pressurised container preferably being fitted with a valve of such a type as to deliver a metered dose of the medicament. Such pressurised packs are fitted with a rigid tube for insertion into the nostril as described above. When inhaling medicaments with this form of applicator it is difiicult to obtain suitable dispersion of the medicament in air as no air is inhaled therewith. Furthermore, dangers may arise from the discharge of a close of medicament into a nostril blocked at its upper end with mucus and its lower end with the applicator, as the expanding dose of medicament may damage the membrane. It is an object of the present invention to provide an improved nasal applicator for applying a medicament contained in a pressurised container.

According to the invention, therefore, there is provided an improved nasal applicator for the application of a medicament contained in a pressurised container which comprises a rigid tube having mounted in the lower part thereof and co-axial therewith a spray button adapted to engage with the stem of a pressurised container and to spray the medicament along the length of the rigid tube, said spray button being mounted in said rigid tube by struts or supports so as to provide air passages between the outside of said button and the inside of said rigid tube. With this applicator, pressure due to expanding propellant cannot build up in the nostril, and in general good dispersion of the medicament in air is obtained.

Preferably the lower end of the rigid tube connects with or forms part of a hollow frusto-conical member which in turn connects with or forms part of a skirt adapted to surround the upper portion of the pressurised container.

In a modification of this arrangement the skirt extends to form a cylindrical casing enclosing the pressurised container; the casing having an opening in the lower end wall thereof to enable the container to be urged towards the spray button, to actuate the container valve, by finger pressure. Alternatively a bush-button may be provided operating through an opening in the lower end wall to urge the container towards the spray button. In order to facilitate manufacture and assembly of the device the cylindrical casing or part thereof may be a separate moulding secured to the skirt by any desired means, e.g., welding, glueing, or, preferably, by a clip fit.

In order to prevent dust from entering the spray tube the device is preferably fitted with a removeable cap fitting over the spray tube. This cap may 'be a simple friction fitting cap fitting over the spray tube or may be more elaborate. For example, an improved form of cap for the applicator has lugs depending from the lower portion thereof which lugs rest upon the shoulders of the pressurised container to prevent accidental discharge of the container. Where the applicator has a lower frustoconical portion, the lugs pass through slots therein and may engage therewith in a bayonet cap action to lock the cap. The applicator and cap are conveniently made of thermoplastic material such as nylon and may be made by injection or other form of moulding.

The applicator is conveniently designed to be used in conjunction with pressurised containers having a nominal capacity of, for example, about 10 cc. Preferably the pressurised container is one having a metering valve, i.e. a valve delivering a metered dose on actuation; a wide variety of such valves being known.

In order that the invention may be well understood a preferred embodiment thereof will now be described with reference to the accompanying drawings in which:

FIGURE 1 is a vertical cross-section through one preferred applicator according to the invention;

FIGURE 2 is a view at the line AA in FIGURE 1;

FIGURE 3 shows the applicator shown in FIGURE 1 in position on a pressurised container;

FIGURE 4 is similar to FIGURE 3 and shows the preferred form of cap in position;

FIGURE 5 is a vertical cross-section through another preferred form of assembly with bayonet locking cap; and

FIGURE 6 is a vertical cross-section through a device similar to that shown in FIGURE 5 but having a simple friction fitting cap.

Referring now to the drawings, an applicator comprises a delivery tube 1 having a shoulder portion 2 and a skirt portion 3. Mounted within tube 1 by means of ribs 5 is spray button 4 which has a stern receiving chamber 6, a spray chamber 7 and spray hole 8. Re ferring to FIGURES 1, 2, 3, 4 and 5, shoulder portion 2 of the applicator is provided with slots 9 to permit passage of lugs 11 of a cap 10 as shown in FIGURES 4 and 5.

FIGURE 3 shows the applicator in position on a pressurised container with chamber 6 surrounding the top of stem 13 of valve 12 of pressurised container 14. In operation depression of the complete applicator mechanism operates valve 12 and the pressurized medicament is expelled via chamber 7 and hole 8 through tube 1 to be inhaled together with air passing between ribs 5.

FIGURES 4 and 5 show cap 10 in position with lugs 11 passing through slots 9 to engage on container 14 to prevent accidental discharge of the device. Preferably lugs 11 co-act with slots 9 so as to lock the cap in position by a bayonet cap action.

Referring now to FIGURES 5 and 6, cylindrical casing 15 clip fits onto the outside of skirt 3 and encloses container 14. Through opening 17 in the lower end wall 16 of casing 15 passes push-button 18 which serves to actuate the dispenser. In a modification of this construction opening 17 is left open and is wide enough to admit a finger to actuate the device. There is a space between the outside of container 14 and the inside of casing 15 to permit the flow of air through the casing. If desired, container 14 may be spaced from the inside of casing 15 by longitudinal ribs. In FIGURE 6, cap 10 is a close friction fit to delivery tube 1.

In operation push-button 18 is pressed to urge container 14 towards spray button .4 to actuate valve 12.

I claim:

1. A nasal applicator, for the application of a medicament contained in a pressurised container having a stem for dispensing the medicament, which comprises a pressurised container, a rigid tube the lower end of which has a hollow frusto-conical member thereon, a skirt on the lower end of said frusto-conical member and surrounding the upper portion of the pressurised container, said rigid tube having mounted in the lower part thereof and coaxial therewith a spray button engaging with the stem of the pressurised container and adapted to spray the medicament along the length of the tube, struts mounting said spray button in said rigid tube so as to provide air passages between the outside of said button and the inside of said rigid tube, a cap having slotted lugs dependent from the lower portion thereof and passing through slots in said hollow frusto-conical member and resting on the pressurised container, said slotted lugs locking the cap in position andpreventing relative movement between said pressurised container and said hollow frusto-conical member in the direction of movement of said tube toward and away from said container.

2. A nasal applicator as claimed in claim 1 in which said slotted lugs each have a lateral extension on the end thereof coacting with said struts to lock said cap in position by a bayonet type action.

3. A nasal applicator, for the application of a medicament contained in a pressurised container having a stem for dispensing the medicament, which comprises a pressurised container, a rigid tube the lower end of which has a hollow frusto-conical member thereon, a cylindrical casing adapted to enclose a pressurised container and having an opening in the lower end wall thereof, a pushbutton extending through said opening in the lower end wall of said cylindrical casing, said rigid tube having mounted in the lower part thereof and coaxial therewith a spray button engaging with the stern of the pressurised container and adapted to spray the medicament along the length of the tube, struts mounting said spray button in said rigid tube so as to provide air passages between the outside of said button and the inside of said rigid tube, a cap having slotted lugs dependent from the lower portion thereof and passing through slots in said hollow frusto-conical member and resting on the pressurised container, said slotted lugs locking the cap in position and preventing relative movement between said pressurised container and said hollow frusto-conical member in the direction of movement of said tube toward and away from said container.

References Cited by the Examiner UNITED STATES PATENTS 2,998,822 9/1961 Birch et a1. 15552 3,001,524 9/1961 Maison et al 128208 3,012,555 12/1961 Meshberg 128-208 RICHARD A. GAUDET, Primary Examiner.

K. L. HOWELL, Assistant Examiner.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2998822 *Jun 12, 1959Sep 5, 1961Herbert M BirchSelf-contained push button applicator
US3001524 *Mar 5, 1957Sep 26, 1961Riker Laboratories IncAerosol dispensing apparatus
US3012555 *May 18, 1959Dec 12, 1961Philip MeshbergDispensing package for material under pressure
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3698390 *Oct 27, 1969Oct 17, 1972Frank Donald FerrisDispensing for medicaments
US5012803 *Mar 6, 1989May 7, 1991Trudell MedicalModular medication inhaler
US5012804 *May 23, 1990May 7, 1991Trudell MedicalMedication inhaler with adult mask
US5074871 *Dec 7, 1989Dec 24, 1991Evi CorporationSurgical removal of plaque from an artery
US5156610 *Nov 26, 1991Oct 20, 1992Evi CorporationCatheter atherotome
US5160342 *Dec 30, 1991Nov 3, 1992Evi Corp.Endovascular filter and method for use thereof
US5211651 *Aug 16, 1990May 18, 1993Evi CorporationCatheter atherotome
US5282484 *Jul 28, 1992Feb 1, 1994Endovascular Instruments, Inc.Method for performing a partial atherectomy
US5435297 *Aug 28, 1992Jul 25, 1995Christoph KleinMedical device for inhaling metered aerosols
US5643297 *Mar 10, 1995Jul 1, 1997Endovascular Instruments, Inc.Intra-artery obstruction clearing apparatus and methods
US5643298 *May 6, 1996Jul 1, 1997Nordgren; Gregory N.Intra-artery obstruction clearing apparatus and methods
US5665098 *Jul 23, 1996Sep 9, 1997Endovascular Instruments, Inc.Unitary removal of plaque
US5746758 *Oct 21, 1996May 5, 1998Evi CorporationIntra-artery obstruction clearing apparatus and methods
US6165187 *Aug 16, 1996Dec 26, 2000Endo Vascular Instruments, Inc.Method of enlarging a lumen of an artery
US6581590 *Mar 21, 2000Jun 24, 2003Iep Pharmaceutical Devices Inc.Inhalation actuated device
US20120017902 *Nov 3, 2009Jan 26, 2012Schering CorporationElastomeric discharge member for nasal delivery device
Classifications
U.S. Classification128/200.23
International ClassificationA61M15/08, A61M15/00, A61M31/00, B65D83/14
Cooperative ClassificationA61M15/009, A61M2015/0025, A61M31/00, A61M15/08, B65D83/386
European ClassificationB65D83/38E2, A61M15/08, A61M15/00P, A61M31/00