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Publication numberUS3356462 A
Publication typeGrant
Publication dateDec 5, 1967
Filing dateAug 9, 1966
Priority dateAug 9, 1966
Publication numberUS 3356462 A, US 3356462A, US-A-3356462, US3356462 A, US3356462A
InventorsNelson M Cooke, Paul H Hall
Original AssigneeCooke Engineering Company
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Disposable microtitration plate
US 3356462 A
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Description  (OCR text may contain errors)

Dec. 5, 1967 N. M. COOKE ETAL 3,356,462

DISPOSABLE MICROTITRATION PLATE Original Filed April 5 1965 5 Sheets-Sheet l INVENTORS Nelson M. Goa/re Paul H. Hall ATTORNEYS Dec. 5, 1967 N. M. COOKE ET L 3,355,462

DISPOSABLE MICROTITRATION PLATE Original Filed April 1963 3 Sheets-Sheet 2 401 I 24' 32' r 1 F v m5 v "26 IN E: R ii 28' Nelson M. Cooke y i g I ubj Paul H. Hall r J ATTORNEY) Dec. 5, 1967 N coo ET AL 3,356,462

DisPosABLE MICROTITRATION PLATE 3 Sheets-Sheet 3 Original Filed April 5 1963 III Ill/[Ir (/1111 III/l IIIIIIIIII 'IIIIIIIIIII INVENTORS Nelson M. Cooke Poul H.Holl

JM, 720% 9 M ATTORNEYS United States Patent 3,356,462 DISPOSABLE MICROTITRATION PLATE Nelson M. Cooke, Great Falls, Va., and Paul H. Hall,

Clinton, Md., assignors to Cooke Engineering Company,

Alexandria, Va., a corporation of Delaware Continuation of application Ser. No. 271,003, Apr. 5,

1963. This application Aug. 9, 1966, Ser. No. 571,357

Claims. (Cl. 23-292) ABSTRACT OF THE DISCLOSURE A disposable microtitration plate comprising a molded, one-piece, plastic shell having a planar top wall, a continuous skirt-like side wall, and a plurality of parallel rows of uniformly arranged cups formed in the top wall and depending into the recess defined by the side wall on the underside of the top wall. The side wall is formed with a support flange which spaces the cup bottoms above and out of contact with a planar support surface. The side wall is further formed with a shoulder which provides a support surface for stacking and locating one plate upon the other.

This is a streamlined continuation of our now abandoned application Ser. No. 271,003, filed Apr. 5, 1963, for Laboratory Apparatus.

This invention relates to laboratory apparatus and, more specifically, to disposable plates for use with microtitration apparatus of the type disclosed in copending application No. 135,364, filed Aug. 31, 1961, by Alan A.-

Duif et al. for Titration Apparatus.

The microtitration apparatus disclosed in the copending application referred to above is especially useful for conducting viral serological investigations and includes a series of Plexiglas plates, each having several rows of recesses which, in the course of a serological investigation, are filled with a minute volume (usually either 0.025 or 0.050 milliliter) of an appropriate diluent.

A number of dilution loops equal to the number of recess rows, each having a liquid-carrying head which usually has a capacity of either 0.025 or 0.050 milliliter, are then filled with a liquid reagent. The filled dilution loops are removed to the Plexiglas plates and inserted into the first diluent filled recess in each row. After rotating the loops to mix the reagent and the diluent, the loops are removed to the adjacent recess in each row and rotated to mix the diluted reagent carried by the loops with the diluent in those recesses. The process is repeated down the rows, progressively decreasing the concentration of the reagent in the recesses. The concentrations thus prepared are then treated or analyzed in accordance with the procedure established for the particular serological investigation being conducted.

The Plexiglas plates disclosed in the copending application referred to above are perfectly satisfactory under most circumstances. However, the Plexiglas plates must be thoroughly cleaned after each test to prevent interference with subsequent test patterns. This is a relatively complex procedure in which the plates are bathed in a sodium hypochlorite or formaldehyde solution for thirty minutes, rinsed thoroughly in running tap water, and placed in a warm detergent wash for thirty minutes. After the detergent wash, the plates are scrubbed with detergent, rinsed in tap water, rinsed in deionized water, and dried. It is also desirable to scrub the plates with a hand brush three times and fill and shake empty three times during each wash and rinse operation.

This cleansing cycle requires too much time and too much attention by trained personnel to be entirely satisfactory for widespread serological investigations as are 3,356,462 Patented Dec. 5, 1967 ice provide novel disposable microtitration plates, thereby eliminating the above-discussed cleansing cycle.

In conjunction with the foregoing object, it is another object of the present invention to provide microtitration plates which are sutficiently inexpensive that they can be discarded after a single use and which, in addition, permit accurate, rapid viral serological investigations to be made.

Disposable microtitration plates have heretofore been constructed; The prior art plates, however, are too flimsy and are not manufactured to sufliciently close tolerances to ensure consistently accurate test results.

It is, therefore, another object of the present invention to provide novel disposable microtitration plates which are substantially sturdier than any heretofore developed and which are fabricated with close tolerances, enabling accurate test results to be consistently obtained.

Additional objects and further novel features of the presentinvention will become more fully apparent from the appended claims and as the ensuing detailed description anddiscussion proceeds in conjunction with the accompanying drawing, in which:

FIGURE 1 is a top plan view of a disposable microtitration plate constructed in accordance with the principles of the present invention;

FIGURE 2 is a bottom view of the microtitration plate of FIGURE 1;

FIGURE 3 is a side view of the microtitration plate of FIGURE 1;

FIGURE 4 is an end view of the microtitration plate of FIGURE 1;

FIGURE 5 is a section through the microtitration plate of FIGURE 1, taken substantially along line 5- 5 of FIG- URE 3;

FIGURE 6 is a top plan view of a second microtitration plate constructed in accordance with the principles of the present invention;

FIGURE 7 is .a bottom view of the microtitration plate of FIGURE 6;

FIGURE 8 is a side view of the microtitration plate of FIGURE 6;

FIGURE 9 is an end view of the microtitration plate of FIGURE 6;

FIGURE 10 is a section through the microtitration plate of FIGURE 6, taken substantially along line 1010 of FIGURE 8;

FIGURES l1 and 12 illustrate diagrammatically the manner in which the novel microtitration plates provided by the present invention are fabricated; and

FIGURE 13 is a sectional view through a stack 0 several plates. I

Referring now to FIGURES 1-5 of the drawing, the novel, disposable microtitration plate 20 of the present invention includes a top wall 22 onto which plural rows of precisely dimensioned, uniformly spaced cups 24 open, and an integral, depending side wall 26 extending around the periphery of top wall 22 for supporting plate 20 on a horizontal work surface. Disposable microtitration plate 20 is preferably molded from a synthetic plastic material such as Vynex, an extruded rigid vinyl sheet material produced by Nixon-Baldwin Chemicals, Inc. of Nixon, NJ. Vynex has exceptional dimensional stability over a wide humidity range, good chemical resistance, a high degree of transparency, high rigidity, excellent vacuum forming properties, low moisture absorption, and is easily fabricated. Other materials having these properties to a greater or lesser degree than Vynex may, of course, be substituted therefor without exceeding the scope of the broaderaspect of the present invention. In one practical embodiment of the present invention, plates 20 are 5.080 inches long, 3.250 inches wide, and are formed of 0.020 inch thick Vynex sheet.

In the illustrated embodiment, there are twelve rows of cups 24 and eight cups in each row, permitting plates 20 to be used for multiple titrations.

Referring now specifically to FIGURE 5, the cups 24 each have a cylindrical side wall 28, a hemispherical end wall 30, and a frusto-conical inlet lip 32. Inlet lip 32 has an apex angle of approximately 90 degrees to ensure complete drainage into cup 24. The juncture of inlet lip 32 and side wall 28 must be a sharp corner to prevent the formation of rings of red cells on the lip adjacent its juncture with the side wall as commonly occurred in prior art plates in which this corner was rounded.

Cylindrical side wall 28 and hemispherical end wall 30 each have a diameter of 0.236 inch. Cups 24 are 0.410 inch in depth. For accurate visual comparison of the contents of the several cups 24 of a given plate 20, it is critical that the depths of cups 24 be equal. A tolerance of plus or minus 0.001 inch is therefore maintained in the commerical embodiment of the present invention.

Referring still to FIGURE 5, the cylindrical side walls 28 of cups 24 vary in thickness between microtitration plate top wall 22 and the lower ends 30 of the cups. This is an important feature of the present invention since by decreasing the side wall thickness, the thickness of the hemispherical end walls 30 is substantially increased in comparison with other arrangements and the cup, as a whole, is much sturdier than those of the prior art devices. Representative plate top wall and cup side and end wall dimensions are as follows:

Measurement: Dimension in inches A 0.012 B 0.010 C 0.003 C 0.002 C 0.008 D 0.017

As will be noted, the end wall of the cup is only .003 inch less than the orginal thickness (.020 inch) of the sheet from which the plate is formed despite the .410 inch depth and .236 inch diameter of the cup.

With continued reference to FIGURE 5, integral flanges 34 and 36 are formed on the lower edge of plate side wall and like reference characters, but primed, have therefore been employed to designate the corresponding portions of microtitration plate 40.

The only substantial distinction between microtitration plates 20 and 40 is that the lower end walls 30 (see especially FIGURE of cups 24 are conical and terminate in a rounded lowered tip 42. Rounded tips 42 eliminate the possibility of air bubbles being trapped in the lower ends of cups 24'. This is extremely important because the reading of the deposit upon the internal surface 44 of the cup end walls 30' is critic-a1 in certain tests.

The inside diameter of cups 24 is on the order of 0.236 inch and their depth is 0.410 inch. The apex angle of rounded tip 42 is on the order of 118 degrees and the internal radius of the rounded tip is on the order of 0.015 inch.

The provision of plates having both conical and rounded end walls permits the microtitration apparatus described in the copending application referred to above to be used for complement fixation tests, metabolic inhibition tests, and the like, as well as hemagglutination tests and hemagglutination inhibition tests to which prior art devices were limited.

Disposable microtitration plates 20 and 40 will normally be sterilized and packaged in hermetically sealed sterile containers to prevent them from being contaminated.

Turning now to FIGURES 11 and 12, disposable microtitration plate 20 is formed from plastic sheet 44' in vacuum molding apparatus provided with a male die 46 and a cooperating apertured die 48. Suitable molding apparatus is well known. For this reason and because its details form no part of the present invention, a detailed description of the molding apparatus is deemed unnecessary.

Formed on male die 46 are a plurality of normally extending projections 50 configured to form cups 24 to the desired shape. The cooperating apertured or female die 48 has through apertures 52 at the cup locations. Male die 46 is fixedly mounted in the molding apparatus and apertured die 48 is mounted for movement toward fixedly mounted die 46 in the direction indicated by the arrow in FIGURE 12.

Male die 46 is heated in any appropriate manner as by forming it of resistive material and connecting it to a source of electrical potential.

Female die 48 is surrounded by an air-tight chamber 54 provided with an outlet 56.

In the plate forming operation, the plastic sheet 44 is arranged between the heated male die 46 and the co-opcrating apertured die 48 and vacuum chamber 54 is evacuated through outlet 56. Apertured die 48 is then moved toward the fixedly mounted male die 46. As the plastic sheet 44' contacts projections 50 of male die 46, it is heated and softened and forced into the apertures 52 in die 48 by the pressure differential existing between the lower and upper sides of the die. As die 48 continues to move toward die 46, projections 50 follow the softened sheet into apertures 52, forming cups 24 to their final configuration.

This novel cooperation of pressure and vacuum acting concomitantly on opposite sides of plastic sheet 44 produces the novel cup side and end wall configurations illustrated in FIGURE 5, substantially increasing the rigidity of cups 24 in comparison to the cups of the prior art devices.

It is to be understood, as will be apparent to one skilled in the art, that the microtitration plate 40 may be formed in a similar manner; that dies 46 and 48 may be appropriately formed to produce the supporting and nesting flanges 34, 36, 38; and that the molding cycle described above may be automatically performed, permitting plates 20 and 40 to be molded at a high rate of speed.

The invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

What is claimed and desired to be secured by Letters Patent is:

1. A disposable plate for microtitration and like purposes comprising a molded, synthetic plastic shell having a planar top wall supported by a continuous depending marginal flange and having a plurality of parallel equal length transversely aligned rows of uniformly arranged, equal depth, open top cups formed in and depending from said top wall in parallel spaced apart relation and in a uniform pattern, said cups having annular side walls the internal surfaces of which are cylindrical and end Walls the thickness of said end walls of said cups being greater than the thickness of said top wall and of said side walls of said cups whereby said cup end walls are provided with increased strength, said depending marginal flange being of a height slightly greater than that of the depending cups whereby contact between the external surfaces of said cup end walls and a planar work surface supporting such plate is precluded so long as said planar top wall is not deformed.

2. The disposable microtitration plate as defined in claim 1 wherein said internal surfaces of said cup end walls are conical and coaxial with said cylindrical surfaces, the diameter of the bases of said conical surfaces being equal to the diameter of said cylindrical surfaces.

3. The disposable microtitration plate as defined in claim 1 wherein said internal surfaces of said cu-p end walls are hemispherical, the centers of said hemispherical surfaces lying on the axes of said cylindrical surfaces and the diameter of said hemispherical surfaces being equal to the diameters of said cylindrical surfaces.

4. The disposable plate defined in claim 1 wherein each of the cup side walls decreases in thickness in directions converging both from said top wall and said cup end wall to a region of minimum thickness intermediate said top wall and said cup end wall, the maximum thickness of the cup side wall above said region being less than the maximum thickness of the cup side wall below said region.

5. A disposable microtitration plate comprising a molded, one-piece, synthetic, plastic shell having a planar top wall, a continuous skirt-like side wall extending around and normally depending from said top wall to delimit a downwardly opening recess beneath said top wall, and a plurality of parallel transversely aligned rows of uniformly arranged, equal depth, open top cups formed in said top wall and depending therefrom into said recess, said cups having annular side walls and end walls, the internal surfaces of said annular side walls being cylindrical, and the internal surfaces of said end walls being surfaces of revolution, the longitudinal axes of said cups being substantially normal to said top wall, said side wall terminating at its end opposite from said top wall in an integral,

continuous support flange extending laterally outwardly from said recess in parallel relation with said top wall, said flange having a flat bottom surface which is adapted to be seated on a planar surface for supporting said top wall, the height between a plane containing the bottom surface of said flange and the said top wall being sufliciently greater than the length of said cups that the cups end Walls are spaced by said flange above and out of contact with said planar surface, said side wall being formed with upper and lower skirt portions respectively joined to said top wall and to said flange, said lower portion being laterally outwardly offset from said upper portion and being joined thereto to define a continuous, planar shoulder having a downwardly facing surface which is parallel to the upper surface of said top wall, said shoulder providing a support surface which is adapted to seat on the top surface of a plate of like construction to enable like plates to be stacked one upon the other, said lower portion cooperating with said shoulder to positively locate one stacked plate with respect to the other with the cups of an upper plate stacked on a lower plate being disposed in axially aligned, nested relation with the cups of the lower plate.

References Cited UNITED STATES PATENTS 2,561,339 7/1951 Chediak 23-253 2,612,261 9/1952 Percopo 20663.2 2,666,951 1/1954 Grove et al 264292 2,911,681 11/ 1959 Distler 264-292 2,965,219 12/1960 Rhodin 206-1 3,057,510 10/ 1962 Blacker 22097 3,097,070 7/ 1963 Aldrich et al 23-253 FOREIGN PATENTS 170,898 4/ 1952 Austria. 378,443 2/ 1940 Italy.

JOSEPH SCOVRONEK, Acting Primary Examiner.

MORRIS O. WOLK, Examiner.

Disclaimer 3,356,46:2.Nels0n M. Cooke, Great Falls, Va", and Paul H. Hall, Clinton, Md. DISPOSABLE MICROTITRATION PLATE. Patent dated Dec. 5, 1967. Disclaimer filed Oct. 8, 1974, by the assignee, Dynatech Laboratorz'es, Incorporated. Hereby enters this disclaimer to claims 1, 2, 3 and 5 of said patent.

[Ofioz'al Gazette April I, 1.975.]

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2561339 *Jan 10, 1944Jul 24, 1951Chediak AlejandroApparatus for laboratory investigations
US2612261 *Oct 29, 1949Sep 30, 1952Squibb & Sons IncSuppository package
US2666951 *Aug 30, 1951Jan 26, 1954Us Rubber CoMethod and apparatus for drawing plastic sheets
US2911681 *Jul 19, 1956Nov 10, 1959Jennings Machine CorpContainers and methods of making them
US2965219 *Mar 16, 1959Dec 20, 1960Johannes A G RhodinTransparent sample holder for pathological specimens and the like
US3057510 *May 25, 1960Oct 9, 1962Blacker William HTray to serve and hold food
US3097070 *Nov 6, 1958Jul 9, 1963Falcon Plastic ProductsPlastic ware for scientific use
AT170898B * Title not available
IT378443B * Title not available
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3441383 *Oct 26, 1966Apr 29, 1969Francis C MooreMultiple cup tray
US3536449 *Apr 13, 1967Oct 27, 1970Astle Thomas WSerial dilution machine
US3540856 *Jan 22, 1968Nov 17, 1970Beckman Instruments IncSample capsule and filtering mechanism
US3759413 *Mar 1, 1971Sep 18, 1973Ardito GContainer
US3768639 *Dec 15, 1971Oct 30, 1973Ferrero & C Spa PDisplay container
US3853217 *Aug 9, 1972Dec 10, 1974Medical Laboratory AutomationPipette tip package
US4200613 *Apr 14, 1978Apr 29, 1980Ramco Laboratories Inc.Radioimmunoassay apparatus
US4221867 *Feb 2, 1979Sep 9, 1980Minnesota Mining And Manufacturing CompanyOptical microbiological testing apparatus and method
US4235971 *Jun 9, 1978Nov 25, 1980Dynatech Laboratories, IncorporatedMulticompartment trays
US4245043 *Jun 29, 1979Jan 13, 1981Minnesota Mining And Manufacturing CompanyNegative control media device and method for microbiologic biochemical tests
US4245052 *Jun 29, 1979Jan 13, 1981Minnesota Mining And Manufacturing CompanyFor colorimetric analysis of microbial growth
US4304330 *May 4, 1979Dec 8, 1981J. S. StaedtlerCase for writing utensils
US4349510 *Jul 23, 1980Sep 14, 1982Seppo KolehmainenMethod and apparatus for measurement of samples by luminescence
US4447398 *Nov 9, 1982May 8, 1984Sequioa TurnerSample container for measurement of ions of body fluids
US4545958 *Apr 18, 1983Oct 8, 1985Behringwerke AktiengesellschaftMicrotitration plate
US4548245 *Mar 4, 1983Oct 22, 1985Dynatech Laboratories IncorporatedDisposable/reusable dispenser for dispensing contaminatable and noncontaminatable liquids
US4761378 *Mar 4, 1983Aug 2, 1988American Home Products Corp. (Del.)Connecting test trays for inoculation, incubation, lyophilization
US4769946 *Nov 4, 1986Sep 13, 1988Bud Antle, Inc.Transplant tray
US4824791 *Jul 9, 1986Apr 25, 1989Labsystems OyThermostated cuvette set
US5113787 *May 20, 1988May 19, 1992Raychem Corp.Optical fiber termination coating dispenser
US5348606 *Sep 23, 1992Sep 20, 1994Hanaway Richard WMethod of making a multiple pipette sampler system
US5366088 *Sep 1, 1993Nov 22, 1994Larcon, North AmericaStackable pipette tip rack
US5514343 *Jun 22, 1994May 7, 1996Nunc, AsMicrotitration system
US5603899 *Apr 12, 1995Feb 18, 1997Pharmacia Biotech, Inc.Multiple column chromatography assembly
US5792654 *Nov 11, 1997Aug 11, 1998Neogen CorporationMicroorganism culture tray
US5985594 *Nov 6, 1996Nov 16, 1999Idexx Laboratories, Inc.Method for quantification of biological material in a sample
US6051191 *Nov 17, 1997Apr 18, 2000Porvair PlcSample well surrounded on its sides by opaque matrix
US6232124Nov 13, 1998May 15, 2001Verification Technologies, Inc.Automated fingerprint methods and chemistry for product authentication and monitoring
US6269846 *Jul 24, 1998Aug 7, 2001Genetic Microsystems, Inc.Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays
US6287797Mar 26, 1999Sep 11, 2001Biocontrol Systems, Inc.Incubation plate having flat horizontal surface with at least twenty recessed wells adapted to hold liquid by surface tension; food and water quality testing
US6458595Jan 24, 2001Oct 1, 2002Verification Technologies, Inc.Automated fingerprint methods and chemistry for product authentication and monitoring
US6490030Jan 18, 1999Dec 3, 2002Verification Technologies, Inc.Portable product authentication device
US6509168Apr 18, 2001Jan 21, 2003Biocontrol Systems, Inc.Detection of preferential particles in sample; liquify sample, pour into plate, incubate in wells, monitor wells and detect preferential particles
US6512580Oct 27, 1999Jan 28, 2003Verification Technologies, Inc.Microplate comprising base layered with porous substrate having absorbed dry light emissive compound so that liquid sample permeates substrate and reacts with compound and with incident radiation, emitting radiation for analysis
US6589626Mar 29, 2001Jul 8, 2003Verification Technologies, Inc.Copy-protected optical media and method of manufacture thereof
US6638593Jun 12, 2001Oct 28, 2003Verification Technologies, Inc.Copy-protected optical media and method of manufacture thereof
US6707539Oct 18, 2002Mar 16, 2004Verification Technologies, Inc.Portable product authentication device
US6722395May 21, 2001Apr 20, 2004James W. OverbeckDepositing fluid specimens on substrates, resulting ordered arrays, techniques for analysis of deposited arrays
US6884615Jul 8, 2003Apr 26, 2005Futaba CorporationMicroplate
US7079230Apr 24, 2000Jul 18, 2006Sun Chemical B.V.Portable authentication device and method of authenticating products or product packaging
US7122338Jan 21, 2003Oct 17, 2006Biocontrol Systems, Inc.Liquefaction; incubation; reduce air bubbles; culture product
US7124944Oct 2, 2002Oct 24, 2006Verification Technologies, Inc.Product packaging including digital data
US7303803Dec 1, 2004Dec 4, 2007Verification Technologies, Inc.Copy-protected optical media and method of manufacture thereof
US7486790Aug 3, 2000Feb 3, 2009Verification Technologies, Inc.Method and apparatus for controlling access to storage media
US7660415Dec 6, 2004Feb 9, 2010Selinfreund Richard HMethod and apparatus for controlling access to storage media
US7977610 *Apr 12, 2004Jul 12, 2011Borgwarner Beru Systems GmbhDevice for receiving ceramic heating elements and method for the manufacture thereof
US8035811Sep 22, 2009Oct 11, 2011Helixis, Inc.Devices and methods for visualization of a sample in a microplate
DE2340106A1 *Aug 8, 1973Feb 21, 1974Medical Laboratory AutomationVerpackung von pipettenspitzen
DE3110239A1 *Mar 17, 1981Oct 7, 1982Seppo KolehmainenMethod and device for measuring the luminescence of samples
DE3441179A1 *Nov 10, 1984May 22, 1986Dynatech Deutschland GmbhTemperature-control device for microcell arrangements, in particular microtitration plates
DE3629272A1 *Aug 28, 1986Mar 5, 1987Kureha Chemical Ind Co LtdMikrotiterplatte
DE4022792A1 *Jul 18, 1990Feb 6, 1992Max Planck GesellschaftPlatte mit zumindest einer mulde zur aufnahme von chemischen und/oder biochemischen und/oder mikrobiologischen substanzen und verfahren zur herstellung der platte
EP0050018A2 *Oct 9, 1981Apr 21, 1982Olympus Optical Co., Ltd.Particle agglutination analysing plate
EP0058428A2 *Feb 16, 1982Aug 25, 1982Eisai Co., Ltd.An enzyme immuno-assay for simultaneously measuring a plurality of samples and test vessel for carrying out this method
EP0082194A1 *Jun 18, 1982Jun 29, 1983American Hospital Supply CorporationImproved biomedical analysis tray
EP0106662A2Oct 12, 1983Apr 25, 1984Dynatech Laboratories, IncorporatedNon-fluorescent vessels for holding test samples in fluorescent assays
EP0171072A2 *Aug 6, 1985Feb 12, 1986Akademie der Wissenschaften der DDRMethod and device for the solid-phase sequencing of nucleic-acid fragments
EP0724482A1 *Oct 17, 1994Aug 7, 1996Carter-Wallace, Inc.Agglutination plate having concave wells
WO1981000063A1 *May 14, 1980Jan 22, 1981Minnesota Mining & MfgDisposable microbial profile tray
WO1981000115A1 *Jun 16, 1980Jan 22, 1981Minnesota Mining & MfgNegative control media for microbiologic biochemical tests
WO1988006723A1 *Feb 24, 1988Sep 7, 1988Bionique Lab IncDisposable immunoassay and biochemical test device suitable for field and office use
WO1992001513A1 *Jan 29, 1991Feb 6, 1992Max Planck GesellschaftPlate with at least one well for holding chemical and/or biochemical and/or microbiological substances, and a process for manufacturing the plate
WO1996001692A1 *Jul 6, 1995Jan 25, 1996Guenther DietzelProcess for producing sample-carriers
WO1998017142A1 *Oct 23, 1996Apr 30, 1998Handelman Joseph HA coin storage device
Classifications
U.S. Classification422/553, 206/564, D24/226, 206/509, 422/942, 264/269, 206/558, 220/23.6, 264/268
International ClassificationB01L3/00
Cooperative ClassificationB01L3/5085
European ClassificationB01L3/5085