Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS3398935 A
Publication typeGrant
Publication dateAug 27, 1968
Filing dateMar 25, 1964
Priority dateMar 25, 1964
Publication numberUS 3398935 A, US 3398935A, US-A-3398935, US3398935 A, US3398935A
InventorsLivesey Donald V, Snow Kenneth A
Original AssigneeBausch & Lomb
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Mixing means
US 3398935 A
Abstract  available in
Images(1)
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

MEANS POSITIONING SUWLYING PRESSURIZED GAS MIXING MEANS &

MEANS POSITIONING MIXING MEANS & SUPFLYIN PRESSURIZED GAS MEANS SUPPLYING CONSTITUENTS TO BE MIXED D. v. LIVESEY ET 3,398,935

MIXING MEANS Filed March 25, 1964 FIG. 3

FIG. 4

FIG. 2

FIG. I

DONALD V. I. E E KENNETH A SIEOV I INVENTORS I BY p nroauats United States Patent 3,398,935 MIXING MEANS Donald V. Livesey, Irondequoit, and Kenneth A. Snow,

Greece, N.Y., assignors to Bausch & Lomb Incorporated, Rochester, N.Y., a corporation of New York Filed Mar. 25, 1964, Ser. No. 354,686 3 Claims. (Cl. 259-18) This invention relates to a means and a method of mixing materials and more specifically mixing without introducing a foreign element into a mixture.

The mixing of constituents for chemical reactions, chemical analysis, or mixtures in general has been accomplished by using a stirring element to uniformly distribute the constituents.

This manner of mixing may contaminate the mixture and create a false indication in analysis, or a variable rate in the chemical reaction or some other undesirable result. Accordingly it is desirable to provide a mixing means whereby no foreign element is introduced into the mixture and the mixing is accomplished by inducing movement of the fluids through fluid friction thereby providing an even more rapid mixing means.

It is an object of this invention to provide a mixing by inducing friction between the constituents and causing a rotary or random movement in the mixture.

It is another object of this invention to provide a mixing of the constituents by inducing the fluid friction to the mixture by a whirling mass of pressurized gas.

It is a further object of this invention to create a vortex of a gas to induce a vortex of liquid and through fluid friction provide a rapid and thorough mixing of constituents.

The objects of this invention are accomplished by providing a container for a number of constituents preferably including a liquid of low viscosity. The constituents are placed in the container and a whirling mass of pressurized gas is then directed on the surface of the liquid. The whirling mass of gas induces the whirling rotation of the liquid in the container causing a vortex in the liquid and a thorough and rapid mixing of the constituents. The vortex of gas may be created by atangential positioned gas jet, or helical orifice means centrally located in the container to create a vortex mixing operation.

The preferred embodiments of this invention are described in the following paragraphs and illustrated in the attached drawings.

FIG. 1 illustrates a container and means for supplying the constituents to be mixed.

FIG. 2 illustrates a tangential gas jet inducing fluid friction in the mixture.

FIG. 3 illustrates helical orifices inducing the gas vortex and through fluid friction creating a liquid vortex for mixing.

FIG. 4 illustrates a sectional view of a helical orifice means.

Referring to FIG. 1 the container 1 is positioned for reception of a mixture of constituents 2 and 3. The number of constituents is immaterial, a means is illustrated for supplying a mixture to the container which may be introduced through the conduit 4 or other conduits which may be reciprocated in and out of the container 1 as indicated by the arrow 5. When the desired amount of constituents are placed in the container 1 the conduit 4 or others are withdrawn from the container.

FIG. 2 illustrates the container 1 containing the constituents. A tube 6 connected to a source of pressurized gas is introduced into the container adjacent the upper surface of the mixture. The mixture preferably includes a liquid of low viscosity which is capable of movement when a gas is directed in a circulating manner on the upper surface of the liquid. The jet 7 creates a whirling mass of gas on the upper surface of the mixture which drags the surface of the liquid with the circular motion and thus induces by fluid friction a vortex in the mixture 8.

FIG. 3 illustrates a tube 9 which may be reciprocated in and out of the container in the manner indicated by the arrow 10 to introduce pressurized gas. The pressurized gas is directed downwardly against the upper surface of the fluid 11. The gas forms a vortex which also induces a vortex as illustrated in the liquid 11. The variable rate of circulation of the various layers in the liquid 11 is created by the rotating vortex axially within the tube and a stationary condition of the container walls on the peripheral engaging portion of the liquid 11. The vortex created in the liquid 11 rapidly mixes the constituents.

FIG. 4 illustrates a section view of the end portion of the hollow tube 9. A plurality of helical orifices 12 passing through a solid cylindrical portion impart a whirling axial motion to the gas as it leaves the orifices. This whirling motion creates a vortex of gas which induces through fluid friction a vortex in the liquid.

The device as illustrated operates in the following described manner. The constituents of a mixture are introduced in FIG. 1 within the container 1. The tube 6 or 9 is then introduced into the open end of the container and creates a whirling mass of gas which engages the fluid surface causing the gas to drag the surface of the liquid in a circular motion. The greater the pressure the greater the rate of motion and the more rapid the mixing of the liquid. The liquid Within the container rotates to form a vortex. The various layers intermediate the gas contacting surface and the liquid contacting the peripheral walls of the container are rotated at varying rates to create a thorough mixing throughout the liquid.

The methods set forth are substantially the same whereby the constituents are introduced into the container and then the vortex of gas is formed within the container and a vortex within the liquid is then induced through fluid friction between the gas and the liquid.

The preferred embodiments of this invention are illustrated and described and it is understood that other embodiments might be devised which would fall within the scope of this invention which is defined by the attached claims.

We claim:

1. Apparatus for mixing a sample containing at least one low viscosity liquid material comprising in combination:

open top container means for holding a sample to be mixed;

conduit means for introducing separate sample constituents to be mixed into the container means;

a mixing tube connected to a source of mixing gas, said mixing tube including helical passage means for the mixing gas;

means for positioning the mixing tube vertically with respect to the sample; and

means for supplying pressurized mixing gas and flowing mixing gas from the helical passage means onto the sample surface in a vortex flow pattern to induce mixing of the sample constituents.

2. The apparatus of claim 1 wherein the mixing tube comprises a substantially solid cylinder portion having multiple helix-shaped passages of uniform flow area, and a hollow tube member surrounding the cylinder portion and connected to the supply means for pressurized mixing gas to the cylinder portion.

3. The apparatus of claim 1 wherein the conduit means may be reciprocated through the open top container means.

Fontein et a1. 2594 Mead 259--4 Manka 2594 X Martin et a1 2594 Hopkins 261-119 X Rumrnel.

10 WALTER A. SCHEEL, Primary Examiner.

J. M. BELL, Assistant Examiner.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2208673 *Mar 3, 1939Jul 23, 1940Hopkins Samuel EAir cleaner for gas engines
US2653801 *Oct 12, 1951Sep 29, 1953StamicarbonProcess and apparatus for dispersing a substance in a liquid
US2795403 *Oct 28, 1954Jun 11, 1957William H MeadSlurry mixing method and apparatus
US2831754 *May 10, 1954Apr 22, 1958Jones & Laughlin Steel CorpSolvent extraction process
US3015554 *Apr 15, 1958Jan 2, 1962Roman RummelMethod and device for carrying out metallurgical processes, particularly air refining processes
US3212757 *Jan 7, 1963Oct 19, 1965Darwin B MaxsonMixing and aerating apparatus
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US4287933 *Oct 31, 1978Sep 8, 1981Korf-Stahl AgContinuous casting method with rotary melt movement
US4529706 *Mar 17, 1983Jul 16, 1985Becton Dickinson And CompanyMethod of stirring
US4597944 *Oct 18, 1983Jul 1, 1986Cottingham Hugh VAgglutination reagent detection system
US4664526 *Sep 18, 1985May 12, 1987Peter SchefflerProcess and apparatus for mixing a liquid sample to be analyzed
US4707452 *Oct 26, 1984Nov 17, 1987Zymark CorporationLaboratory evaporation
US4759634 *May 21, 1986Jul 26, 1988Jede-Automater AbBeverage preparing and dispensing apparatus
US4815978 *Apr 30, 1986Mar 28, 1989Baxter Travenol Laboratories, Inc.Clinical analysis methods and systems
US4957010 *Jul 25, 1989Sep 18, 1990W. R. Grace & Co.-Conn.Method and apparatus for determining particle size distribution
US5052813 *Mar 19, 1990Oct 1, 1991Brian LattoTube type vortex ring mixers
US5080868 *May 16, 1990Jan 14, 1992Elgas David HSparger assembly
US5246632 *May 21, 1992Sep 21, 1993Wentworth Fred Albert JrCirculatory ion vapor generator and method
US5362147 *Sep 21, 1993Nov 8, 1994Boehringer Mannheim GmbhMethod and apparatus for the contactless automatic mixing of a reaction mixture in an analysis unit
US6264895Feb 26, 1999Jul 24, 2001Robert S. JohnsonPan, enclosure, air drawing source
US6827901May 2, 2002Dec 7, 2004Ventana Medical Systems, Inc.Improved biological reaction platform which can be used for a wide variety of assays, such as, automatic immunostaining of tissue sections, in situ DNA analysis, and immunoassays
US6943029Jan 22, 2002Sep 13, 2005Ventana Medical Systems, Inc.Automated biological reaction apparatus
US7118918Aug 16, 2001Oct 10, 2006Ventana Medical Systems, Inc.Apparatus for the continous preparation of samples; for use in immunological staining, nucleotide sequences analysis, immunoassays
US7400983Dec 19, 2003Jul 15, 2008Dako Denmark A/SInformation notification sample processing system and methods of biological slide processing
US7470541Nov 17, 2004Dec 30, 2008Ventana Medical System, Inc.Using carousel device to zonally dispense immunoglobulin mixture to slides; immunostaining
US7648678Dec 8, 2003Jan 19, 2010Dako Denmark A/SProcessing immobilized tissue samples in vertical position in automated staining apparatus; histology
US7758809Dec 3, 2009Jul 20, 2010Dako Cytomation Denmark A/SIncluding a slide positioner adapted to pivot a slide between a submerged position and a position in which reagent can be applied to the tissue sample; pivoting of slides ensures an appropriate orientation of the slides for both pretreatment and staining
US7937228Mar 19, 2008May 3, 2011Dako Denmark A/SInformation notification sample processing system and methods of biological slide processing
US7960178Dec 19, 2003Jun 14, 2011Dako Denmark A/SEnhanced scheduling sample processing system and methods of biological slide processing
US8216512Dec 19, 2003Jul 10, 2012Dako Denmark A/SApparatus for automated processing biological samples
US8257968Dec 19, 2003Sep 4, 2012Dako Denmark A/SMethod and apparatus for automatic staining of tissue samples
US8298815Dec 22, 2003Oct 30, 2012Dako Denmark A/SSystems and methods of sample processing and temperature control
US8323984 *Dec 19, 2002Dec 4, 2012Beckman Coulter, Inc.Using air jet mixing to prepare homogenous mixtures of whole blood for leukocyte hematological analysis
US8386195Mar 28, 2011Feb 26, 2013Dako Denmark A/SInformation notification sample processing system and methods of biological slide processing
US8394635May 6, 2011Mar 12, 2013Dako Denmark A/SEnhanced scheduling sample processing system and methods of biological slide processing
US8529836Jun 11, 2012Sep 10, 2013Dako Denmark A/SApparatus for automated processing biological samples
US8663978Aug 6, 2012Mar 4, 2014Dako Denmark A/SMethod and apparatus for automatic staining of tissue samples
US8673642Feb 4, 2013Mar 18, 2014Dako Denmark A/SEnhanced scheduling sample processing system and methods of biological slide processing
US8784735Aug 12, 2013Jul 22, 2014Dako Denmark A/SApparatus for automated processing biological samples
US8788217Jan 23, 2013Jul 22, 2014Dako Denmark A/SInformation notification sample processing system and methods of biological slide processing
EP0176014A2 *Sep 13, 1985Apr 2, 1986Eppendorf-Netheler-Hinz GmbhMethod and device for mixing a liquid sample to be analysed
EP0281958A2 *Mar 4, 1988Sep 14, 1988Hoechst AktiengesellschaftDevice for controlling the temperature and mixing the contents of the vessels of a micro-titration plate
EP0589363A1Sep 17, 1993Mar 30, 1994Boehringer Mannheim GmbhMethod and device for automatic mixing without contact of a reaction mixture in a analysing device
WO1985003571A1 *Jan 16, 1985Aug 15, 1985William C HuletteClinical analysis systems and methods
WO1987004943A1 *Feb 12, 1986Aug 27, 1987Zymark CorpControl of laboratory evaporation
WO1987006618A1 *Mar 3, 1987Nov 5, 1987Baxter Travenol LabClinical analyses methods and systems
WO2003051516A1 *Nov 20, 2002Jun 26, 20033M Innovative Properties CoDesiccator system having modular elements
WO2013158312A1 *Mar 15, 2013Oct 24, 2013Hyclone Laboratories, Inc.Methods and apparatus for gas stream mass transfer with a liquid
Classifications
U.S. Classification366/101, 366/165.1, 261/119.1
International ClassificationB01F13/00, B01F13/02
Cooperative ClassificationB01F13/0272
European ClassificationB01F13/02J