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Publication numberUS3420931 A
Publication typeGrant
Publication dateJan 7, 1969
Filing dateApr 20, 1965
Priority dateApr 23, 1964
Also published asDE1216486B, US3554767
Publication numberUS 3420931 A, US 3420931A, US-A-3420931, US3420931 A, US3420931A
InventorsWhilhelm Daum, Hans Joachim Sippel
Original AssigneeMerck Ag E
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Pharmaceutical dragee
US 3420931 A
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Description  (OCR text may contain errors)

United States Patent 3,420,931 PHARMACEUTICAL DRAGEE Whilhelm Daum, Eberhard Nurnberg, and Hans Joachim Sippel, Darmstadt, Germany, assignors to E. Merck A.G., Darmstadt, Germany No Drawing. Filed Apr. 20, 1965, Ser. No. 449,637 Claims priority, application Germany, Apr. 23, 1964,

M 60,752 US. Cl. 424-33 14 Claims Int. Cl. A61k 9/00; B44d 1/00 ABSTRACT OF THE DISCLOSURE An improved method for producing drages wherein the drage coating solution comprises about 35-60% by weight of sugar and about -10% by weight of a vinyl polymer, such as polyvinyl pyrrolidone, this method permitting automatic operation, and markedly reducing the time conventionally employed for producing drages.

This invention relates to the production of sugar containing coatings on shaped masses of ingestible solid material.

Whereas this invention is broadly directed to the production of sugar-containing coatings on shaped masses of ingestible solid material, it has particular application to the production of drages.

By the term drage is meant a shaped mass of solid material having thereon a sugar-containing coating of substantial thickness. The shaped mass, for example, a pill or tablet, is not limited to any particular geometrical shape. It contains a pharmaceutical composition, i.e., active ingredient and, if necessary, excipients. For the purposes of this invention, a shaped mass without a sugarcontaining coating will be referred to as a core.

Though it may appear to be a simple task, heretofore the production of drages has been excessively time-consuming. To build up an aesthetically acceptable coating ofsufiicient thickness, the practice has been to apply several thin coats with scrupulous care to prevent the drages from adhering to one another, as well as to avoid nonuniformity of the final product. As a matter of fact, even under the watchful eye of a master drage maker, the time for making one batch has amounted to about one week, on the average.

An object of this invention, therefore, is to provide an improved process for the production of coated shaped masses of solid material, and in particular to an improved process for the production of drages.

Upon further study of the specification and claims, other objects and advantages of the present invention will become apparent.

To attain these objects, there is provided a process which basically comprises coating a core with an aqueous dispersion comprising, in percent by weight, 1 to 60, preferably 35 to 40% of a sugar and 0.5 to 10% of a vinyl polymer, preferably a polymer of vinyl pyrrolidone and/ or a polymer of vinyl acetate.

It has been previously suggested to incorporate vinyl polymers, more particularly polyvinyl pyrrolidone, for the coating of medicaments in the manufacture of varnished or film-coated tablets. In this process, the compressed medicament is coated with a solution of these high molecular weight substances alone, the solutions being applied to the tablets or other pressings in any suitable way, for example by spraying. Varnished or film-coated tablets obtained in this way cannot be regarded as drages since they have only a thin coating of varnish consisting of the polymer and they do not have a conventional drage coating made up principally of sugar and the abovementioned additives. The use of a vinyl polymer in ice the coloring of drages, that is drages which already have the actual drage coating has also been described in the literature Kohler et al., Deutsch Opotheker-Zeitung 102 (1):l-8, Jan. 4, 1962. The coating pigment suspension used contained 0.325% of polyvinyl pyrrolidone in addition to sugar and other substances and is used to color the drages by pigment dyes, that is only for the last stage of the drage process.

=If this suspension described in literature is used as the sole coating composition for the coating process and is applied to the uncoated cores, it is found that the coating process is very considerably lengthened unless pulverulent substances, such as talc, are additionally introduced into the rotating vessel. The surface of the drages obtained tends to be sticky and a large number of applications is necessary.

Using the coating composition according to the invention, it has surprisingly been found that the entire coating process can be carried out with this composition alone since it can be applied manually or by suitable apparatus, with or without spraying, without any inconvenient sticking of the drages. It has not been found necessary to additionally introduce pulverulent substances such as talc, into the rotating vessel during the time of the coating process. With rationalized operation, the entire coating process can be carried out in one or two days. It was particularly unexpected that such a substantial improvement can be achieved by increasing the polymer from 0.325% to at least 0.5%, preferably to about 2%.

The preferred polymers include homopolymers of vinyl pyrrolidone, vinyl acetate, and vinyl alcohol, and copolymers of vinyl pyrrolidone-vinyl acetate, and vinyl alcohol. These polymers are characterized by their physiological compatibility.

It has been particularly advantageous to apply commercial preparations of polyvinyl pyrrolidone with a dry content of at least 94 percent, a maximal ash content of 0.02 percent and a maximal monomer content of 0.8 percent, molecular weights between 10,000 and 800,000, preferably about 20,000 to 30,000, showing viscosity parameters K of between 17 and 90, preferably about 25.

(The viscosity parameter K is defined by the following equation:

wherein Z is the relative viscosity of a solution of the concentration 0 volume percent.)

Another polymer which is used advantageously is a commercial copolymer of 60 percent vinyl pyrrolidone and 40 percent vinyl acetate with the following characteristics: dry content: at least 95 percent; maximal monomer conent: 0.8 percent; viscosity parameter K: 34:6; nitrogen content: about 7.6%.

The molecular weight of the polymer can vary widely. In general, polymers of molecular weights between about 10,000 and 2,000,000 are applied. It is important, however, that the monomer content of the polymer is kept as low as possible because of the possibly toxic side effects of higher concentrations of some of the monomers. In general, monomer contents lower than 1 percent by weight are unobjectionable.

As for the other essential ingredients of the coating, the percent by weight of sugar in the aqueous suspension is 1 to 60, preferably 35 to 40. Various types of sugars can be employed, such as sucrose, glucose, sorbitol, mannitol, etc.; it is preferable, however, to use sucrose.

Aside from water, sugar, and polymer, it is possible to incorporate other materials in the dispersion. The effectiveness of the vinyl polymers, particularly of the polyvinyl pyrrolidone, can be increased by adding other highmolecular compounds, such as cellulose derivatives, e.g.

methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, or starches, e.g. potato, corn, wheat, rice starch, or star-ch gum. It is, for instance, possible to reduce the polymer content to one half of the original by adding about 0.5 percent by weight of one of the cellulose derivatives mentioned. This is a considerable economical and, in some cases, also a processing improvement.

Moreover, the suspension may contain pigments, such as titanium dioxide or calcium carbonate, lubricants (talc or finely divided silica), fillers such as flour, binders, plasticizers and/ or softeners, e.g. glycerine, and preservatives. Usually, in accordance with one advantage of this invention, the addition of preservatives can be avoided because it is possible to work up a batch in a few days and during this time no growth of bacteria or fungi occurs.

The viscosity of the final dispersion can vary widely, depending on the composition of it, furthermore on temperature, air content, thixotropic effects, previous agitation and even time. In general, the viscosity of the dispersion is between 500 and 15,000, preferably about 2000 centipoise.

By using the dispersion of this invention, it was surprisingly discovered that it is possible to conduct the entire coating process only with one coating composition. This is the case because the dispersion of this invention can be applied either manually or mechanically, with or without spraying, and without the drages sticking to one another. Of most importance is that it is possible to carry out the entire coating process within one to two days. In contrast thereto, the average working time for the manufacture of one batch according to the conventional process is approximately one week. Thus, compared with the usual process, the new process represents a considerable saving of time, resulting in substantial labor savings, as well as in substantially increased plant capacity.

As another distinct advantage, the dispersion of this invention is so stable that it is unnecessary during the course of drages manufacture to use mixing or stirring devices, pumps, or other homogenizing equipment to prevent settling. A still further advantage of the invention consists of the fact that during the course of the whole process, there is no requirement for organic solvents. Moreover, during the course of the process it is unnecessary to employ intermediate drying steps for which purpose, in the usual coating processes, the drages had to be removed temporarily from the coating vessel.

Heretofore, in the usual coating processes, it has always been necessary during the course of the coating procedure to introduce powdery materials into the coating suspension. This was done by either the coating operator in a strewing motion, or by the use of complicated spray equipment always being subject to both clogging and breakdown. In contrast, the process of this invention avoids such disadvantages, because according to this proccess it is possible to apply the suspension onto the drage cores at room temperature, manually or by machine, without the necessity of either spraying or streawing in powdery materials.

The application of the coating dispersion can be adapted to different types of operation. It is possible to lay on the coating either manually, or semi-automatically or completely automatically. The suspension can be applied by spraying or it can be poured in liquid form directly onto the cores tumbling in an angularly oriented rotating kettle. The suspension is applied until the material to be coated is well moistened. The kettle is then allowed to rotate until the coated cores no longer adhere to one another but instread roll freely. Finally, the coated cores are dried under continuous rotation, preferably with the aid of a warm air stream, or an infrared lamp, or any other equivalent drying means. These steps can be conducted continuously; and it is possible in this connection, to shorten or even omit the rotating phase (second phase) during the first coating applications. It is also unnecessary to remove the drages from the coating vessel during the course of the entire coating procedure in order to postdry them, perhaps, under vacuum or in drying chambers. A further essential advantage of this invention consists in that all of the process steps can be conducted at ambient temperature. In general each core is coated with 10 to 500, preferably 50 to separate thin coats, each coat having a thickness of 0.5 to 200 preferably 5 to 2011..

A particularly economical mode of conducting the process comprises passing a predetermined volume of the suspension through -a relay-controlled solenoid valve into the drage coating vessel to cover the drages rolling around therein. Suitably, a three-phase time relay is employed, such that in the first phase the suspension is passed through the solenoid valve; in the second phase the rotating operation is conducted, the duration of which can be varied; and in the third phase the heating device is actuated. The suspension can be applied onto cores whose surface is not pretreated. However, it is also possible to coat cores which have been previously provided with a sugarless coating, for instance with a lacquer coating resistant to stomach acids.

The drages produced in accordance with this invention cannot be distinguished by their exterior from those which are produced according to the classical method of coating drages. They likewise taste sweet, can be colored, exhibit a natural silky sheen, and can, if desired, be lacquered. Their elastic and mechanical strengths meet the highest requirements.

The quantity of suspension depends on the weight and the shape of the drage cores. Normally, the quantity is 10 to of the weight of the core, on a dry basis.

With respect to the finished product, the ratio of the components in the drage coating is the same as that of the coating solution, the exception being, of course, that water and/or other solvents are absent in the final coatmg.

Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the specification and claims in any way whatsoever.

The following examples are those for the manufacture of the suspension to be employed according to this invention.

EXAMPLE 1 Percent Polyvinyl pyrrolidone 4 Titanium dioxide 4.5 Calcium carbonate 4.5 Talc 14.5 Glycerine 2 Sucrose 38 Water 32.5

Polyvinyl pyrrolidone is dissolved in water; then, the remaining components are added under constant stirring; thereafter, the mixture is passed through a fine sieve or a homogenizing device.

EXAMPLE 2 Percent Methyl cellulose 0.5 Polyvinyl pyrrolidone 2.0

Aerosil (particulate SiO 4.0 Titanium dioxide 4.5

Calcium carbonate 4.5

Talc 14.5

Glycerine 2.0

Sucrose 38.0

Water 30.0

5 EXAMPLE 3 Percent Hydroxyethyl cellulose 0.5 Polyvinyl pyrrolidone-polyvinyl acetate copolymer (proportion 6:4) 2.0 Titanium dioxide 4.5 Calcium carbonate 4.5 Talc 18.5 Glycerine 2.0 Sucrose 38.0 Water 30.0

EXAMPLE 4 Percent Swelling amylose 0.5 Polyvinyl alcohol 2.0 Titanium dioxide 4.5 Calcium carbonate 4.5 Talc 18.5 Glycerine 2.0 Sucrose 38.0 Water 30.0

EXAMPLE 5 Percent Carboxy methyl cellulose 0.5 Polyvinyl alcohol polyvinyl acetate copolymer 2.0 Titanium dioxide 4.5 Calcium carbonate 4.5 Talc 18.5 Glycerine 2.0 Sucrose 38.0 Water 30.0

EXAMPLE 6 Percent Methyl cellulose 0.5 Polyvinyl pyrrolidone (average molecular weight 650,000) 0.5 Titanium dioxide 4.5 Calcium carbonate 4.5 Talc 20.0 Glycerine 2.0 Sucrose 38.0 Water 30.0

EXAMPLE 7 Percent Methyl cellulose 0.5 Polyvinyl pyrrolidone (average molecular weight Titanium dioxide 4.5 Calcium carbonate 4.5 Silicon dioxide 4.0 Talc 6.5 Glycerine 2.0 Sucrose 38.0 Water 30.0

EXAMPLE 8 Percent Methyl cellulose 0.5 Polyvinyl pyrrolidone 2.0 Aerosil (particulate SiO 4.0 Titanium dioxide 6.5 Calcium carbonate 6.5 Magnesium stearate 2.5 Glycerine 3 .0 Sucrose 45.0 Water 30.0

35 mg. lactose, 20 mg. corn starch, and mg. talc, are mixed manually in a conventional drage vessel having a diameter at the opening of cm., with 0.5 liter of a suspension (produced in accordance with Example 2), at a rate of rotation of 15 revolutions per minute. The rotation is continued for 10 minutes and then for a further 10 minutes with a forced hot air (temperature 30-40 C.; 4.5 m. /minute). This processcoating, rotating, dryingis repeated over again until a weight of the individual coated cores of mg. is reached. Finally, the drages are kept in motion for a while longer with air being blown in, for the purpose of obtaining a silky shine which is preserved by applying a solution of bee wax in carbon tetrachloride, or another suitable polishing agent, and subsequent rotating for 1 to 2 hours. Total duration of the drage production process: 16 hours (2 working days).

EXAMPLE 10 40 kg. of cores, each core weighing 420 mg. and consisting of 250 mg. pyridoxine hydrochloride, 100 mg. lactose, 50 mg. corn starch, and 20 mg. carboxymethyl cellulose, are placed into a drage coating vessel of a width of 90 cm. at its opening. 25 kg. of a suspension, produced according to Example 5 and mixed with 1% coloring agent (TartraZine, Hydrazine yellow, FD&C yellow No. 5), are added piecemeal at ambient temperature from a storage vessel with the aid of a solenoid valve controlled 'by means of a 3-phase timing relay. The three phases of the relay are set as follows: 1st Phase (coating application): 5 seconds; 2nd Phase (rotating without hot air supply): 10 minutes; 3rd Phase (rotating with hot air blown in as in Example 8): 10 minutes. The drage coating process is continued until the individual weight of the resultant drages amounts to 600 mg., whereupon a polishing step is conducted as in Example 8. Total duration of drage manufacturing process: 16 hours (2 working days).

By means of this process, drages are obtained which have a drage coating that is colored in all layers. It is also possible to utilize first a colorless suspension and to apply a colored suspension only at the end of the drage producing process.

From the preceding examples, it is seen that this invention provides a substantial improvement in the sugar coating of shaped masses of solid material. Aside from coating drages, it is apparent that this invention can be employed for the coating of other orally ingestible products, such as variously-colored sugar coated candies, particularly sugar-coated chocolates.

Whereas the preceding examples indicated specific time cycles of (a) a coating application, (b) a rotating step, and (c) a drying step, it is to :be understood that these times can be varied greatly, the important consideration 'being that on a comparative basis, the coating dispersion of this invention provides improved results over prior art coatings used for the same purpose. For preferred operation, however, the following time cycles are used:

Time 1-60 Step:

(a) Coating application seconds (b) Rotating (tumbling) time in a conventional drage coater having a 90 cm. diameter at the opening and a rotational velocity of 5 to '60 revolutions per minute min:utes (c) Drying time with either forced air having a temperature of 20 to 70 C., or an equivalent heat input minutes pill or tablet core containing active ingredient and excipient coated from at least about 10% of the weight of the core, on a dry basis, with 10-500 separate thin coats, each coat having a thickness of about -200 microns, and dried from an aqueous dispersion comprising about 35-60% by weight of sugar and about 05-10% by weight of a vinyl polymer selected from the group consisting of homopolymer of vinyl pyrrolidone, homopolymer of vinyl acetate, homopolymer of vinyl alcohol, copolymer of vinyl pyrrolidone-vinyl acetate and copolymer of vinyl alcohol-vinyl acetate.

2. A drage as defined by claim 1 wherein said vinyl polymer is polyvinyl pyrrolidone.

3. A drage as defined by claim 1 wherein said coats further comprise not more than about 30% by weight of another solid material selected from the group consisting of talc, finely divided silica, calcium carbonate, titanium dioxide and mixtures thereof.

4. A drage as defined by claim 1 wherein said aqueous dispersion further comprises about 0.5% by weight of a member selected from the group consisting of methyl cellulose, ethyl cellulose, carboxymethyl cellulose, bydroxyethyl cellulose, hydroxypropyl cellulose, and starch.

5. A drage as defined by claim 1 wherein said coats comprise about -100% by weight of the core, on a dry basis.

6. A drage as defined by claim 1 wherein at least 50 separate thin coats are employed.

7. A drage as defined by claim 2 wherein said coats comprise about 10100% by weight of the core, on a dry basis.

8. A drage as defined by claim 1 wherein the aqueous dispersion contains at least about 2% of the vinyl polymer.

9. A drage as defined by claim 2 wherein the aqueous dispersion contains at least about 2% of the polyvinyl pyrrolidone.

10. A process for the production of a drage as defined by claim 1 comprising the steps of pouring the aqueous dispersion directly on cores tumbling in an angularly oriented rotating kettle; continuing the rotating until the coated cores roll freely; and then drying the coated cores.

11. A process as defined by claim 10 wherein the process is conduced automatically.

12. A process as defined by claim 10 wherein the coated cores are not removed from the kettle until the entire number of coats are applied.

13. A process as defined by claim 10 wherein all the steps are conducted at ambient temperatures.

14. A process as defined by claim 10 wherein the process is conducted automatically in the same kettle, the time for the coating step being 1-60 seconds, the time for the rotating step being 1-60 minutes, and the time of drying being 1-60 minutes, the entire process taking not more than two days.

References Cited UNITED STATES PATENTS 3,331,696 7/1967 Rieckmann et al. 106208 3,256,153 6/1966 Heirnlich 167-82 3,148,123 9/1964 Werner l67-82 3,097,144 7/1963 Banker 16782 2,991,226 7/1961 Millar et a1. l67-82 2,954,322 9/1960 Heilig et al. 167-82 OTHER REFERENCES Kohler et al.; Deutsche Apotheker-Zeitung 102(1) :1-8, Jan. 4, 1962.

LEWIS GOTTS, Primary Examiner.

S. K. ROSE, Assistant Examiner.

US. Cl. X.R.

Patent Citations
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Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3524756 *May 29, 1967Aug 18, 1970ColorconProcess of coating tablets with alternate tacky and non-tacky layers
US3753767 *Aug 2, 1971Aug 21, 1973Colgate Palmolive CoMethod of sugar-coating tablets
US3835221 *Mar 4, 1971Sep 10, 1974Hoechst AgOrally administrable drug dosage form having delayed action
US3935326 *Apr 22, 1974Jan 27, 1976Boehringer Mannheim G.M.B.H.Process for coating tablets with aqueous resin dispersions
US4001390 *Apr 1, 1975Jan 4, 1977Shin-Etsu Chemical Co., Ltd.Smooth and noncracking surface
US4017647 *Jun 9, 1975Apr 12, 1977Shin-Etsu Chemical Company LimitedConversion of water-soluble polymeric salt into water-insoluble polymeric acid
US4060598 *Oct 28, 1975Nov 29, 1977Boehringer Mannheim G.M.B.H.Tablets coated with aqueous resin dispersions
US4150111 *Feb 10, 1977Apr 17, 1979Allister WarrenEnteric coated magnesium chloride
US4432966 *Aug 31, 1982Feb 21, 1984Roussel-UclafSustained release
US4693896 *Oct 7, 1985Sep 15, 1987Fmc CorporationEthylcellulose-coated, gastric-disintegrable aspirin tablet
US4851226 *Jun 30, 1988Jul 25, 1989Mcneil Consumer Products CompanyCellulose acetates, polyvinyl pyrrolidone
US4867984 *Feb 17, 1989Sep 19, 1989Nagin K. PatelAspirin, acetomenophen
US5334253 *Nov 13, 1990Aug 2, 1994Lloyd BergSolution of certain five and six carbon atom carbohydrates
US5494681 *Aug 11, 1994Feb 27, 1996Kv Pharmaceutical CompanyMolten blend of active material, spatially oriented matrix comprising wax core material, hydrophobic polymer
US5800601 *Mar 14, 1997Sep 1, 1998Videojet Systems International, Inc.Food grade jet inks
US6248391 *Jul 16, 1997Jun 19, 2001Bpsi Holdings, Inc.Mixing primary film-former comprising dextrose, auxiliary film-former, sodium citrate and titanium dioxide into water to form aqueous coating dispersion, applying dispersion onto substrates, drying white film coating
US6267808 *Jan 5, 2001Jul 31, 2001Bpsi Holdings, Inc.Mixture of dextrose, film forming, sodium citrate and titanium dioxide
US6747072 *Jan 22, 1997Jun 8, 2004Marconi Data Systems Inc.Ink jet printing on food items, candy, particularly dark candy,
Classifications
U.S. Classification424/479, 424/482, 524/56, 524/44, 427/2.18, 426/289, 524/47, 524/46
International ClassificationA23G3/34, A23G3/26, A23G4/02, A23G4/20, A61K9/32, A23G3/20, A61K9/28, A23G3/00, A23G4/00
Cooperative ClassificationA61K9/2826, A23G3/343, A23G4/20, A23G2200/06, A23G2200/00, A61K9/284, A23G4/025, A23G3/54, A23G3/26, A23G3/20
European ClassificationA23G3/34C, A61K9/28H6B, A61K9/28H4B, A23G4/20, A23G3/26, A23G3/20, A23G4/02P, A23G3/54