|Publication number||US3433226 A|
|Publication date||Mar 18, 1969|
|Filing date||Jul 21, 1965|
|Priority date||Jul 21, 1965|
|Publication number||US 3433226 A, US 3433226A, US-A-3433226, US3433226 A, US3433226A|
|Inventors||Charles A Boyd|
|Original Assignee||Aeroprojects Inc|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (5), Referenced by (186), Classifications (35) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Vibratory catheterization apparatus and method of using
US 3433226 A
5 12&- 3 1:
March 18, 1969 c. A. BOYD 3,433,226
VIBRATORY CATHETERIZATION APPARATUS AND METHOD OF USING Filed July 21, 1965 w n y 7 2o 22 et! I a INVENTOI? CHARLES A. BOYD ATTORNEYS.
United States Patent 3,433,226 VIBRATORY CATHETERIZATION APPARATUS AND METHOD OF USING Charles A. Boyd, West Chester, Pa.,'assignor to Aeroprojects Incorporated, West Chester, Pa., a corporation of Pennsylvania Filed July 21, 1965, Ser. No. 473,596 US. Cl. 128-305 Int. Cl. A61b 17/32; A6111 1/00; A6lm 25/00 Claims ABSTRACT OF THE DISCLOSURE This invention relates to the use of ultrasonic energy for therapeutic purposes, and more particularly to a therapeuticvmethod and apparatus for such purposes as localization and yibratory treatment of irculatioy blocking ..L9 2i 1:@9 z inatieassiiiifi A 4; those occurring in various types of a cl rosis in:
It has been suggested heretofore to use ultrasonic energy in treating patients having subdeltoid bursitis with the energy reportedly being externally applied through the a skin over the affected area via a liquid petrolatum coupling agent, using an intensity of preferably 0.5 watt/ C1132:
ar 1d a maximum of 1.5 watts/cm The ul'fras'onic en e-rgy produces a powerful and deep micromassage, exerts localized thermal action, and increases interacellular me tabolism; it causes exud-ates and precipitates to be absorbed and tissue deposits to be broken up; it loosens tissue, relieves edema, decreases liypertonicity of the muscle, and produces a local analgesia causing an immediate relief of pain. (Page 73, The Indication and Contraindications for Ultrasonic Therapy in Medicine" by J. H. Aldes, in Ultrasound in Biology and Medicine, American Institute of Biological Sciences, Washington. DC, Publication No. 3, 1957) It is to be noted that in this bursitis experimentation, the externally applied ultrasonic energy was ineffective in 52. percent of the cases in decreasing or eliminating calcareous deposit. It has also been suggested (page 161, Ultrasonic Technology by Richard G. Goldman, New York: Reinhold Publishing Corp., 1962): r
It is interesting also to speculate on the possibility of inserting a small transducer into the stomach or heart, which can then irradiate gall stones or calcinations at close range with localized effect.
Moreover, at page l6l of the July-September 1964 3,433,226 Patented Mar. 18 1969 issue (vol. 2) of Ultrasonics, in a Letter to the Editor, there was reported an unsuccessful attempt to apply ultrasonic energy with the end object of emulsifying atherom atous material while leaving the strong fibrous coat of the artery intact or re-boring atheromaobstructed arteries too small for conventional endarterectomy. Thus, postmortem specimens of arteries affected by various degrees. of atheroma were irradiated in water with ultrasound for at least 30 minute periods at frequencies of 20 kc. and l mc. using 50 and 60 watts of power with piezoelectric crystals, and also at 13 kc. using up to 100 watts of power with an industrial magnetostrictive transducer. There was no obvious effect whatever in the 13 kc. experiments, and the only macroscopic effect in the 20 kc. and 1 mc. experiments was co'agulation partly due to "heat.
In other work, a commercial general-purpose apparatus (advertised to enable production of a widerange of effects in chemistry, biology, pharmacology, metallurgy, etc.) was impractical for blood vessel decalcification. Touching a solid acoustical coupling member probe (part of an. ultrasonic apparatus having a design frequency of 20 kc.' and a maximum average output of watts) to atheromatous placques for 15-20 seconds resulted in decimation of the placques; however, there was shearing of the silver braze joint joining the probe to the remainder of the apparatus. Further experiments, with a catenoidal coupling .mem-ber attached to the same basic apparatus, with an in--*- p'u't'to the transducer of 9 watts (power level), readily cleared atheromatous material from cadaver coronary vessels but, after one minute of ultrasonic energy application, tissue heating with destruction of specimens was often apparent.
The present invention overcomes the disadvantages of the prior art and indicates that tissue heating can be eliminated by using a hollow internally cooled catheter. Excellent results on atheromatous aorta tissue were 'obtained by passing ambient saline or a low molecular weight dextran solution through the probe. 0n cadaver coronary vessels, the atheromata was reduced to micron size particles using a power level of 2.6 watts. Said par ticles can then be flushed away by use of a dextran solution.
It is an object of .the present invention to provide novel apparatus and method for vibratory catheterization.
It is another object of the present invention to provide an ultrasonic catheter for internal therapeutic purposes.
It is a further object of the present invention to provide a catheter for decimation of atheromatous placques without hetiting tissues or destruction of specimens.
Another object of the present invention is to provide apparatus for Treatment of coronary artery disease by u sonic coronary endarterectomy.
For the purpose of illustrating the invention there is shown in the drawings a form which is presently preferred, it being understood, however, that this invention is not limited to the precise arrangements and instrumentalitie's shown.
FIGURE 1 is a sectional view of a catheter.
FIGURE 2 is a sectional view of the tip end of another embodiment.
FIGURE 3 is a sectional view of the tip end of another embodiment.
Referring to the drawings, wherein like reference characters refer to like parts, there is shown'in FIGURE 1 an ultrasonic catheter generally designated as 10.
The catheterlg is essentially an ultrasonic transducercoupling system comprising an ult rasonic transducer 12, an acoustical coupling member 14, another acoustical coupling member 16, and a third acoustical coupling member 18 having an end face or tip 20. Member 18 is hollow and metallurgically joined to merriber 14 in line with passageway 22. Passageway 23 intersects passageway 22. Conduit 24 is connected to member 14 in passageway 23.
Catheter is designed to operate at a given frequency, which is preferably a resonant frequency. Catheter 10 is preferably dimensioned to have an over-all physical length equivalent to an acoustical length of a whole number multiple of one-half wavelength in the material of which it is made at the said frequency (see FIGURE 1 wherein "n" indicates a whole number). For efficient operation, there is an antinode (loop) area of the vibration at the end face 20.
Transducer 12 may be of the magnetostrictive type as shown and of conventional construction comprising a half-wavelength long laminated core of nickel, nickel-iron alloy, or other magnetostrietive material, properly dimensioned to insure axial resonance with the frequency of alternatlng current applied thereto by coil 1 -1 so as to cause it to increase or decrease in length according to its coefiicient of magnetostriction. The detailed construction of a suitable magnetostrietive transducer is well known to those skilled in the art and does not form a part of the present invention and, accordingly, no description of its construction will be made herein. It will be appreciated by those skilled in the art that in place of the magnetostrictive transducer 12 other known types of transducers may be substituted; for example, an electrostrictive or piezoelectric transducer made of bariuriftitar'iate, quartz crystals, lead zirconate titanate, etc., may be utilized.
Transducer 12 is provided with an excitation coil '11 and a polarizing coil 13. Excitation coil 11 is connected to a power supply (incorporating an amplifier, not shown, and oscillator, not shown) suitable for powering the transducer 12; such equipment is well known to the art. The desirability of magnetically polarizing the magnetostrictive transducer 12 by means of polarizing coil 13, in order for the metal laminations in said transducer to efiiciently convert the applied energy from excitation coil 11 into elastic vibratory energy, is also readily understood by those skilled in the art. Low voltage direct current can be supplied to coil 13 by battery, rectifier, or other means well known to the art.
The aforesaid power supply system, in a typical example, is capable of producing electrical signals in the range of between about 60 cycles per second and about 300,000 cycles per second. This frequency range is suitable for purposes of the present invention, including as it does frequencies in both the audible range (such as up to about 15,000 cycles per second) and the ultrasonic range (generally above about 15,000 cycles per second). A preferred frequency would be in the range of from about 3,000 to about 50,000 cycles per second with the optimum being between about 14,000 to about 35,000 cycles per second. Normally, a frequency is chosen which will provide a suitable size of apparatus for a given application or set of applications, with the ultrasonic range having the further advantage of inaudibility for operator comfort.
Thus, catheter transducer-coupling system 10 may be constructed to operate at 28,000 cycles per second, for example. In an embodiment of FIGURE 1, a 100 watt power supply was used to drive a transducer 12 at said 28 kc. design frequency.
As is well known to the art, the electrical frequency of the alternating current power supply (sirch as 60 cycles per second) is changed to match the mechanical or elastic vibratory frequency of the transducer (28,000 cycles per second in this example, as aforesaid).
The member 18 is preferably semi-flexible and can be curved within certain limits established by the acoustic characteristics to facilitate manipulation. Preferably, the curvature of the member 18 has a bend ra'dius which is at least x/4 wherein X is the wavelength of the material of member 18. The reason for this limitation on the bend radius is set forth rnore clearly in Patent 3,166,840.
'A coolant fluid may be introduced through conduit 24 and passageway 2]. to cop] the member 18, to irrigate tis sue in the vicinity of the tip 20, and flush away any micron sized particles resulting from decimation of placques. A low molecular weight dextran solution at a temperature of from about ambient temperature to body temperature may be pumped through the system at low pressure. The solution exits through the tip 20. The micron sized particles of the placques result from the physical effect of the vibrating catheter tip 20 upon calcified atheromata.
Sterilization of the catheter can be accomplished utilizing conventional sterilization equipment. If desired, the member 18 may be provided with removable tips which can be disposable. In order to facilitate sterilization or autoclaving, and simultaneously facilitate manipulation of the catheter with minimum power losses, a force-insensitive mount 15 is provided. One end of mount 15 is metallurgically joined to the coupling member 14. The other end of mount 15 is free. The mount 15 is provided with a radially outwardly directed flange 17. Flange 17 is joined to a housing 25 with a waterproof joint. Housing 25 may constitute a handle and is preferably of sufiicient length so as to encase the transducer 12 as shown. Suitable plug-in connections 27, 27' can be provided hermetically sealed to the housing 25 for electrically connecting to the coils 11 and 13, and to facilitate autoclaving the catheter.
A force-insensitive mount may comprise a sleeve such as the described in US. Patents 2,891,178; 2,891,179; and
2,891,180. The disclosures of such patents are incorporated herein by reference. Such a mount facilitates the application of force necessary to insert the catheter into a cavity, artery, or the like. The sleeve is made from a metal such as steel or any other suitable resonant material and has a length equal to a single one-half wavelength. The sleeve surrounds 'the coupler 14 and is concentric therewith and spaced therefrom.
The flange 17 is spaced from the free end of mount 15 by an acoustical distance corresponding to one-quarter wavelength according to the properties of the mount and the desired frequency of operation. The mount 15 when so constructed .will cause a true node of vibratory energy to be developed in the flange 17 so that no vibratory energy will be transmitted to the housing 25.
The operable usage of the ultrasonic endarterectomy catheter requires that a reliable source of vibratory energy be coupled to the working tip 20 having a diameter of the order of a millimeter. The members 16 and 18 may have a length of around 18 inches. To prevent temperature build-up and thereby minimize thermal damage to the tissue, a cooling system as described above is required.
The vibrational energy generated by the transducer can be coupled to the members 16 and 18 in several different modes. The first and simplest mode is that of longitudinal vibration, as shown, wherein the particle displacements occur in a direction parallel to the axis of members 16 and 18. A second mode of vibration is that of lateral or transverse vibration wherein particle displacements occur in a direction normal to the axis of members 16 and 18. This results in an excursion of the tip 20 parallel to the plane of the end face thereof. Other more complicated modes including torsional vibration wherein the system oscillates periodically in torsion about its own axis, or a radial vibration wherein the end tip 20 periodically ex= pands and contracts radially may be utilized.
The exact mechanism by which the placques of the calcified atheromata are destroyed is not well understood. The nature of the mechanism will depend in part on the physical characteristics of the vibrating tip. Several tip geometries may be employed where desired: In FIGURE 1, the geometry of the removable tip 20 is a square edge. As shown more clearly in FIGURE 2, the tip 20 remov= ably mounted on a coupling member 18' may have a chisel edge defined by an internal beveled surface 26. In FIGURE 2, the beveled surface 26 provides a sharp cut ting edge at the periphery.
A third type of tip is illustrated in FIGURE 3. Tip 20' removably mounted on coupling member 18" is in 53 bulbous form, The bulb 28 may be either metal or plastic. The purpose of bulb 28 is to provide a more positive contact between the working surface of the catheter and the tissue being treated. The surface of bulb 28 may have an abrasive character. The tips of FIGURES 2 and 3 may be substituted for the tip 20' in FIGURE 1.
The method steps and conditions for practicing the present invention for treatment of disease or other conditions for therapeutic purposes is considered to be suf ficiently known to those skilled in the art so as not to require a detailed explanation. Using the known principle of oxygen in solution, at 3 atmospheres positive pressure ischemia induced by introducing the catheter by way of the coronary ostia can be prevented. The flow of coolant, such as low molecular weight dextran, can replace oxygenated blood for long periods and prevent a means of oxygenation to the myocardium.
The present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof and, accordingly, reference should be made to the appended claims rather than to the foregoing specification as indicating the scope of the invention,
It is claimed:
1. A catheter comprising a transducer means for gen erating vibratory energy, a resonant coupling member having one end connected to said transducer and a tip at its other end. the end of said tip being at an anti-node on said member, said member having an acoustical length of a whole number multiple of one-half wavelength in the material of which it is made at the frequency of said transducer means, and said member being partially hol= low with the hollow portion beginning at said tip, whereby a liquid for cooling said member may be pumped through said portion for discharge through said tip.
2. A catheter in accordance with claim 1 including a housing, said member being hermetically sealed to said housing with said transducer means disposed within said housing.
3. A catheter in accordance with claim 1 wherein said 6 transducer means is axially coupled to said member for vibrating said member in a direction corresponding to the longitudinal axis of said member.
4. A catheter in accordance with claim 1 wherein said tip has an end face which is substantially perpendicular to the longitudinal axis of said member. F
5. A catheter in accordance with claim 1 wherein said tip is bulbous.
6. A catheter in accordance with claim 1 wherein said tip has an internal beveled face providing a sharp-edge at the periphery of the tip.
7. A catheter in accordance with claim 1 wherein said coupling member has a length of approximately 18 inches and a diameter along a substantial length thereof beginning at the tip of approximately 1 millimeter.
8. A method comprising the steps of transmitting acoustical vibratory energy from a transducer means through a resonant coupling member at least a portion of which is hollow beginning from a tip end of said coupling member designed to have an anti-node at the end face of the tip, introducing a coolant through said portion for dis-' charge through said tip, and transmitting the vibratory energy from the tip to a living animal by contacting the portion of the animal with said tip.
References Cited UNITED STATES PATENTS 2,230,997 2/1941 Chambers et al. 2,407,690 9/1946 Southworth. 3,358,677 12/1967 Sheldon 128-24 FOREIGN PATENTS 540,428 4/1922 France. 991,494 6/ 1951 France.
L. W. TRAPP, Primary Examiner.
US. Cl. X.R. HS-24, 348
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2230997 *||Dec 23, 1937||Feb 11, 1941||Univ Pennsylvania||Method of extracting constituents of living cells|
|US2407690 *||May 16, 1941||Sep 17, 1946||Bell Telephone Labor Inc||Wave guide electrotherapeutic system|
|US3358677 *||Oct 23, 1964||Dec 19, 1967||Sheldon Edward Emanuel||Supersonic therapeutic device with means for introducing fluid into a body cavity|
|FR540428A *|| ||Title not available|
|FR991494A *|| ||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3565062 *||Jun 13, 1968||Feb 23, 1971||Ultrasonic Systems||Ultrasonic method and apparatus for removing cholesterol and other deposits from blood vessels and the like|
|US3570476 *||Nov 18, 1968||Mar 16, 1971||David Paul Gregg||Magnetostrictive medical instrument|
|US3636943 *||Oct 27, 1967||Jan 25, 1972||Ultrasonic Systems||Ultrasonic cauterization|
|US3823717 *||Apr 16, 1973||Jul 16, 1974||Pohlman R||Apparatus for disintegrating concretions in body cavities of living organisms by means of an ultrasonic probe|
|US3908637 *||Apr 22, 1974||Sep 30, 1975||Louis W Doroshow||Rigid urethral instrument|
|US4188952 *||Sep 12, 1978||Feb 19, 1980||Loschilov Vladimir I||Surgical instrument for ultrasonic separation of biological tissue|
|US4269176 *||Nov 24, 1978||May 26, 1981||Siemens Aktiengesellschaft||Treatment head for electromedical diagnostic or therapeutic treatment of body parts|
|US4504264 *||Sep 24, 1982||Mar 12, 1985||Kelman Charles D||Surgical instrument|
|US4526571 *||Oct 15, 1982||Jul 2, 1985||Cooper Lasersonics, Inc.||Curved ultrasonic surgical aspirator|
|US4531934 *||Dec 21, 1982||Jul 30, 1985||Gorkovsky Gosudarstvenny Meditsinsky Institute Imini S.M. Kirova||In an ultrasonic device|
|US4561438 *||Dec 17, 1984||Dec 31, 1985||Richard Wolf Gmbh||Piezoelectric transducer with curved shafts|
|US4650466 *||Nov 1, 1985||Mar 17, 1987||Angiobrade Partners||Angioplasty device|
|US4750488 *||Feb 27, 1987||Jun 14, 1988||Sonomed Technology, Inc.||Vibration apparatus preferably for endoscopic ultrasonic aspirator|
|US4750902 *||May 19, 1986||Jun 14, 1988||Sonomed Technology, Inc.||Endoscopic ultrasonic aspirators|
|US4808153 *||Nov 17, 1986||Feb 28, 1989||Ultramed Corporation||Device for removing plaque from arteries|
|US4832683 *||Jul 15, 1986||May 23, 1989||Sumitomo Bakellite Company Limited||Surgical instrument|
|US4921484 *||Jul 25, 1988||May 1, 1990||Cordis Corporation||Mesh balloon catheter device|
|US4922902 *||Dec 16, 1987||May 8, 1990||Valleylab, Inc.||Method for removing cellular material with endoscopic ultrasonic aspirator|
|US4931038 *||Dec 2, 1987||Jun 5, 1990||Gipharmex S.P.A.||Complex of products for the rapid and not-invasive treatment of biliary calculosis|
|US4962755 *||Jul 21, 1989||Oct 16, 1990||Heart Tech Of Minnesota, Inc.||Method for performing endarterectomy|
|US4982730 *||Dec 21, 1988||Jan 8, 1991||Lewis Jr Royce C||Ultrasonic wound cleaning method and apparatus|
|US5058570 *||Nov 27, 1986||Oct 22, 1991||Sumitomo Bakelite Company Limited||Ultrasonic surgical apparatus|
|US5084010 *||Feb 20, 1990||Jan 28, 1992||Devices For Vascular Intervention, Inc.||System and method for catheter construction|
|US5127917 *||May 17, 1990||Jul 7, 1992||Schneider (Europe) A.G.||Probe, especially for the recanalization of occlusions, and catheter arrangement with such a probe|
|US5269291 *||Dec 10, 1990||Dec 14, 1993||Coraje, Inc.||Miniature ultrasonic transducer for plaque ablation|
|US5304115 *||Jan 11, 1991||Apr 19, 1994||Baxter International Inc.||Ultrasonic angioplasty device incorporating improved transmission member and ablation probe|
|US5324255 *||Jul 10, 1992||Jun 28, 1994||Baxter International Inc.||Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm|
|US5334183 *||Apr 9, 1992||Aug 2, 1994||Valleylab, Inc.||Endoscopic electrosurgical apparatus|
|US5342292 *||May 24, 1993||Aug 30, 1994||Baxter International Inc.||Ultrasonic ablation device adapted for guidewire passage|
|US5344395 *||Jan 24, 1992||Sep 6, 1994||Scimed Life Systems, Inc.||Apparatus for intravascular cavitation or delivery of low frequency mechanical energy|
|US5368557 *||May 5, 1993||Nov 29, 1994||Baxter International Inc.||Ultrasonic ablation catheter device having multiple ultrasound transmission members|
|US5368558 *||Jun 3, 1993||Nov 29, 1994||Baxter International Inc.||Ultrasonic ablation catheter device having endoscopic component and method of using same|
|US5380274 *||Oct 12, 1993||Jan 10, 1995||Baxter International Inc.||Ultrasound transmission member having improved longitudinal transmission properties|
|US5382228 *||Sep 28, 1993||Jan 17, 1995||Baxter International Inc.||Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device|
|US5390678 *||Oct 12, 1993||Feb 21, 1995||Baxter International Inc.||Method and device for measuring ultrasonic activity in an ultrasound delivery system|
|US5397301 *||Jul 19, 1993||Mar 14, 1995||Baxter International Inc.||Ultrasonic angioplasty device incorporating an ultrasound transmission member made at least partially from a superelastic metal alloy|
|US5405318 *||Sep 28, 1993||Apr 11, 1995||Baxter International Inc.||Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels|
|US5417672 *||Oct 4, 1993||May 23, 1995||Baxter International Inc.||Connector for coupling an ultrasound transducer to an ultrasound catheter|
|US5423797 *||Apr 25, 1994||Jun 13, 1995||Medelex, Inc.||Acoustic catheter with rotary drive|
|US5427118 *||Oct 4, 1993||Jun 27, 1995||Baxter International Inc.||Ultrasonic guidewire|
|US5443443 *||Aug 17, 1993||Aug 22, 1995||Surgical Systems & Instruments, Inc.||Atherectomy system|
|US5447509 *||Oct 4, 1993||Sep 5, 1995||Baxter International Inc.||Ultrasound catheter system having modulated output with feedback control|
|US5474530 *||Jun 8, 1994||Dec 12, 1995||Baxter International Inc.||Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasospasm|
|US5480379 *||Oct 4, 1993||Jan 2, 1996||La Rosa; Antonio||Ultrasonic dissector and detacher for atherosclerotic plaque and method of using same|
|US5490859 *||Apr 29, 1993||Feb 13, 1996||Scimed Life Systems, Inc.||Expandable intravascular occlusion material removal devices and methods of use|
|US5501694 *||Mar 3, 1994||Mar 26, 1996||Scimed Life Systems, Inc.||Expandable intravascular occlusion material removal devices and methods of use|
|US5549601 *||Oct 11, 1994||Aug 27, 1996||Devices For Vascular Intervention, Inc.||Delivery of intracorporeal probes|
|US5725494 *||Nov 30, 1995||Mar 10, 1998||Pharmasonics, Inc.||Apparatus and methods for ultrasonically enhanced intraluminal therapy|
|US5728062 *||Nov 30, 1995||Mar 17, 1998||Pharmasonics, Inc.||Apparatus and methods for vibratory intraluminal therapy employing magnetostrictive transducers|
|US5735811 *||Nov 30, 1995||Apr 7, 1998||Pharmasonics, Inc.||Catheter|
|US5792157 *||Sep 30, 1996||Aug 11, 1998||Scimed Life Systems, Inc.||Expandable intravascular occlusion material removal devices and methods of use|
|US5810859 *||Feb 28, 1997||Sep 22, 1998||Ethicon Endo-Surgery, Inc.||Apparatus for applying torque to an ultrasonic transmission component|
|US5836868 *||Mar 25, 1996||Nov 17, 1998||Scimed Life Systems, Inc.||Expandable intravascular occlusion material removal devices and methods of use|
|US5846218 *||Sep 5, 1996||Dec 8, 1998||Pharmasonics, Inc.||Balloon catheters having ultrasonically driven interface surfaces and methods for their use|
|US5897567 *||Sep 9, 1997||Apr 27, 1999||Scimed Life Systems, Inc.||Expandable intravascular occlusion material removal devices and methods of use|
|US5919186 *||May 8, 1997||Jul 6, 1999||Bath; Patricia E.||Laser apparatus for surgery of cataractous lenses|
|US5931805 *||Jun 2, 1997||Aug 3, 1999||Pharmasonics, Inc.||Catheters comprising bending transducers and methods for their use|
|US5968060 *||Feb 28, 1997||Oct 19, 1999||Ethicon Endo-Surgery, Inc.||Ultrasonic interlock and method of using the same|
|US5989274 *||Dec 20, 1996||Nov 23, 1999||Ethicon Endo-Surgery, Inc.||Methods and devices for improving blood flow to a heart of a patient|
|US5989275 *||Feb 28, 1997||Nov 23, 1999||Ethicon Endo-Surgery, Inc.||Damping ultrasonic transmission components|
|US6001069 *||May 1, 1998||Dec 14, 1999||Ekos Corporation||Ultrasound catheter for providing a therapeutic effect to a vessel of a body|
|US6030212 *||Sep 27, 1996||Feb 29, 2000||Dentsply Research & Development Corp.||Stacking reservoir and scaler system|
|US6083192 *||Feb 14, 1997||Jul 4, 2000||Bath; Patricia E.||Pulsed ultrasound method for fragmenting/emulsifying and removing cataractous lenses|
|US6135976 *||Sep 25, 1998||Oct 24, 2000||Ekos Corporation||Method, device and kit for performing gene therapy|
|US6171265||Jan 7, 1998||Jan 9, 2001||Storz Endoskop Gmbh||Handpiece for use with a multifunctional operating endoscopic instrument|
|US6176842||Sep 21, 1998||Jan 23, 2001||Ekos Corporation||Ultrasound assembly for use with light activated drugs|
|US6210356||Aug 5, 1998||Apr 3, 2001||Ekos Corporation||Ultrasound assembly for use with a catheter|
|US6221038||Nov 27, 1996||Apr 24, 2001||Pharmasonics, Inc.||Apparatus and methods for vibratory intraluminal therapy employing magnetostrictive transducers|
|US6228046||Mar 3, 1998||May 8, 2001||Pharmasonics, Inc.||Catheters comprising a plurality of oscillators and methods for their use|
|US6274963||Aug 31, 1999||Aug 14, 2001||Ethicon Endo-Surgery, Inc.||Methods and devices for controlling the vibration of ultrasonic transmission components|
|US6287272||Dec 4, 1998||Sep 11, 2001||Pharmasonics, Inc.||Balloon catheters having ultrasonically driven interface surfaces and methods for their use|
|US6293793||Sep 29, 1999||Sep 25, 2001||Dentsply Research & Development Corp.||Stackable reservoir and scaler system|
|US6312402||Sep 24, 1998||Nov 6, 2001||Ekos Corporation||Ultrasound catheter for improving blood flow to the heart|
|US6325811||Oct 5, 1999||Dec 4, 2001||Ethicon Endo-Surgery, Inc.||Blades with functional balance asymmetries for use with ultrasonic surgical instruments|
|US6387109||Aug 3, 1999||May 14, 2002||Ethicon Endo-Surgery, Inc.||Methods and device for improving blood flow to heart of a patient|
|US6432118||Aug 28, 2000||Aug 13, 2002||Ethicon Endo-Surgery, Inc.||Multifunctional curved blade for use with an ultrasonic surgical instrument|
|US6464660||Mar 14, 2001||Oct 15, 2002||Pharmasonics, Inc.||Balloon catheters having ultrasonically driven interface surfaces and methods for their use|
|US6482218 *||Oct 23, 1998||Nov 19, 2002||Khanh Vien Tran||Wire-shaped ultrasonic catheter with diamond coated head for ultrasonic angioplasty|
|US6527759||Jul 20, 2000||Mar 4, 2003||Ekos Corporation||Ultrasound assembly for use with light activated drugs|
|US6689086||Jul 29, 1999||Feb 10, 2004||Advanced Cardiovascular Systems, Inc.||Method of using a catheter for delivery of ultrasonic energy and medicament|
|US6723063||Jun 29, 1998||Apr 20, 2004||Ekos Corporation||Sheath for use with an ultrasound element|
|US6794369 *||Aug 9, 2002||Sep 21, 2004||Pharmasonics||Methods, systems, and kits for intravascular nucleic acid delivery|
|US6929632||Jun 27, 2002||Aug 16, 2005||Advanced Cardiovascular Systems, Inc.||Ultrasonic devices and methods for ablating and removing obstructive matter from anatomical passageways and blood vessels|
|US6942677||Feb 26, 2003||Sep 13, 2005||Flowcardia, Inc.||Ultrasound catheter apparatus|
|US6958070||Oct 18, 2001||Oct 25, 2005||Witt David A||Curved clamp arm tissue pad attachment for use with ultrasonic surgical instruments|
|US6976969||Jan 14, 2002||Dec 20, 2005||Ethicon Endo-Surgery, Inc.||Blades with functional balance asymmetries for use with ultrasonic surgical instruments|
|US7137963||Aug 26, 2002||Nov 21, 2006||Flowcardia, Inc.||Ultrasound catheter for disrupting blood vessel obstructions|
|US7186246||Mar 6, 2003||Mar 6, 2007||Ekos Corporation||Ultrasound catheter with utility lumen|
|US7220233||Apr 8, 2003||May 22, 2007||Flowcardia, Inc.||Ultrasound catheter devices and methods|
|US7335180||Nov 24, 2003||Feb 26, 2008||Flowcardia, Inc.||Steerable ultrasound catheter|
|US7384407||Dec 3, 2002||Jun 10, 2008||Ekos Corporation||Small vessel ultrasound catheter|
|US7393330||Feb 16, 2006||Jul 1, 2008||Broncus Technologies, Inc.||Electrosurgical device having hollow tissue cutting member and transducer assembly|
|US7413556||Feb 18, 2003||Aug 19, 2008||Ekos Corporation||Sheath for use with an ultrasound element|
|US7422563||Feb 21, 2002||Sep 9, 2008||Broncus Technologies, Inc.||Multifunctional tip catheter for applying energy to tissue and detecting the presence of blood flow|
|US7439654||Feb 24, 2004||Oct 21, 2008||Air Products And Chemicals, Inc.||Transmission of ultrasonic energy into pressurized fluids|
|US7462162||Jul 19, 2004||Dec 9, 2008||Broncus Technologies, Inc.||Antiproliferative devices for maintaining patency of surgically created channels in a body organ|
|US7494468||Feb 21, 2003||Feb 24, 2009||Omnisonics Medical Technologies, Inc.||Ultrasonic medical device operating in a transverse mode|
|US7503895||Feb 24, 2003||Mar 17, 2009||Omnisonics Medical Technologies, Inc.||Ultrasonic device for tissue ablation and sheath for use therewith|
|US7540852||Aug 26, 2004||Jun 2, 2009||Flowcardia, Inc.||Ultrasound catheter devices and methods|
|US7604608||Jan 14, 2003||Oct 20, 2009||Flowcardia, Inc.||Ultrasound catheter and methods for making and using same|
|US7621902||Aug 24, 2006||Nov 24, 2009||Flowcardia, Inc.||Ultrasound catheter for disrupting blood vessel obstructions|
|US7621929||Jul 11, 2005||Nov 24, 2009||Flowcardia, Inc.||Ultrasound catheter apparatus|
|US7708712||Jul 19, 2004||May 4, 2010||Broncus Technologies, Inc.||Methods and devices for maintaining patency of surgically created channels in a body organ|
|US7727178||Dec 21, 2006||Jun 1, 2010||Ekos Corporation||Catheter with multiple ultrasound radiating members|
|US7771372||Jan 5, 2004||Aug 10, 2010||Ekos Corporation||Ultrasonic catheter with axial energy field|
|US7774933||May 4, 2006||Aug 17, 2010||Ekos Corporation||Method of manufacturing ultrasound catheters|
|US7794414||Feb 9, 2004||Sep 14, 2010||Emigrant Bank, N.A.||Apparatus and method for an ultrasonic medical device operating in torsional and transverse modes|
|US7828762||Dec 21, 2006||Nov 9, 2010||Ekos Corporation||Catheter with multiple ultrasound radiating members|
|US7914470||Apr 1, 2004||Mar 29, 2011||Celleration, Inc.||Ultrasonic method and device for wound treatment|
|US7914509||Feb 15, 2007||Mar 29, 2011||Ekos Corporation||Ultrasound catheter|
|US7955293||Aug 23, 2006||Jun 7, 2011||Flowcardia, Inc.||Ultrasound catheter for disrupting blood vessel obstructions|
|US7976483||Dec 12, 2003||Jul 12, 2011||Ekos Corporation||Ultrasound assembly with increased efficacy|
|US7993308||Jan 28, 2005||Aug 9, 2011||Ekos Corporation||Ultrasound enhanced central venous catheter|
|US8002782||Sep 23, 2005||Aug 23, 2011||Ethicon Endo-Surgery, Inc.||Curved clamp arm tissue pad attachment for use with ultrasonic surgical instruments|
|US8043251||Aug 7, 2009||Oct 25, 2011||Flowcardia, Inc.||Ultrasound catheter and methods for making and using same|
|US8062566||Jul 25, 2006||Nov 22, 2011||Flowcardia, Inc.||Method of manufacturing an ultrasound transmission member for use in an ultrasound catheter device|
|US8083707 *||Apr 16, 2004||Dec 27, 2011||Tosaya Carol A||Non-contact damage-free ultrasonic cleaning of implanted or natural structures having moving parts and located in a living body|
|US8133236||Nov 7, 2006||Mar 13, 2012||Flowcardia, Inc.||Ultrasound catheter having protective feature against breakage|
|US8152753||Aug 7, 2009||Apr 10, 2012||Flowcardia, Inc.||Ultrasound catheter and methods for making and using same|
|US8167831||Apr 16, 2010||May 1, 2012||Ekos Corporation||Catheter with multiple ultrasound radiating members|
|US8192363||Oct 25, 2007||Jun 5, 2012||Ekos Corporation||Catheter with multiple ultrasound radiating members|
|US8221343||Jan 20, 2005||Jul 17, 2012||Flowcardia, Inc.||Vibrational catheter devices and methods for making same|
|US8226566||Jun 12, 2009||Jul 24, 2012||Flowcardia, Inc.||Device and method for vascular re-entry|
|US8226629||Mar 31, 2009||Jul 24, 2012||Ekos Corporation||Ultrasonic catheter power control|
|US8235919||Apr 7, 2003||Aug 7, 2012||Celleration, Inc.||Ultrasonic method and device for wound treatment|
|US8241312||Aug 17, 2005||Aug 14, 2012||Ethicon Endo-Surgery, Inc.||Blades with functional balance asymmetries for use with ultrasonic surgical instruments|
|US8246643||Jul 18, 2008||Aug 21, 2012||Flowcardia, Inc.||Ultrasound catheter having improved distal end|
|US8308677||Jun 3, 2011||Nov 13, 2012||Flowcardia, Inc.||Ultrasound catheter for disrupting blood vessel obstructions|
|US8409167||Oct 5, 2006||Apr 2, 2013||Broncus Medical Inc||Devices for delivering substances through an extra-anatomic opening created in an airway|
|US8469982||Apr 7, 2011||Jun 25, 2013||Ethicon Endo-Surgery, Inc.||Curved clamp arm for use with ultrasonic surgical instruments|
|US8491521||Jul 17, 2008||Jul 23, 2013||Celleration, Inc.||Removable multi-channel applicator nozzle|
|US8496669||Dec 21, 2007||Jul 30, 2013||Flowcardia, Inc.||Ultrasound catheter having protective feature against breakage|
|US8506519||Jul 16, 2007||Aug 13, 2013||Flowcardia, Inc.||Pre-shaped therapeutic catheter|
|US8608724||Nov 4, 2010||Dec 17, 2013||Broncus Medical Inc.||Devices for delivering substances through an extra-anatomic opening created in an airway|
|US8613751||Jan 28, 2008||Dec 24, 2013||Flowcardia, Inc.||Steerable ultrasound catheter|
|US8617096||Feb 1, 2011||Dec 31, 2013||Flowcardia, Inc.||Ultrasound catheter devices and methods|
|US8623040||Jul 1, 2009||Jan 7, 2014||Alcon Research, Ltd.||Phacoemulsification hook tip|
|US8641630||Jul 7, 2010||Feb 4, 2014||Flowcardia, Inc.||Connector for securing ultrasound catheter to transducer|
|US8647293||May 22, 2008||Feb 11, 2014||Flowcardia, Inc.||Therapeutic ultrasound system|
|US8668709||Feb 25, 2008||Mar 11, 2014||Flowcardia, Inc.||Steerable ultrasound catheter|
|US8672959||Jun 21, 2013||Mar 18, 2014||Ethicon Endo-Surgery, Inc.||Curved clamp arm for use with ultrasonic surgical instruments|
|US8679049||Jul 17, 2012||Mar 25, 2014||Flowcardia, Inc.||Device and method for vascular re-entry|
|US8690818||Dec 21, 2011||Apr 8, 2014||Ekos Corporation||Ultrasound catheter for providing a therapeutic effect to a vessel of a body|
|US8690819||Nov 9, 2012||Apr 8, 2014||Flowcardia, Inc.||Ultrasound catheter for disrupting blood vessel obstructions|
|US8696612||Mar 27, 2012||Apr 15, 2014||Ekos Corporation||Catheter with multiple ultrasound radiating members|
|US8709034||May 13, 2011||Apr 29, 2014||Broncus Medical Inc.||Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall|
|US8740835||Feb 17, 2011||Jun 3, 2014||Ekos Corporation||Treatment of vascular occlusions using ultrasonic energy and microbubbles|
|US8784400||May 16, 2012||Jul 22, 2014||Broncus Medical Inc.||Devices for delivering substances through an extra-anatomic opening created in an airway|
|US8790291||Apr 22, 2009||Jul 29, 2014||Flowcardia, Inc.||Ultrasound catheter devices and methods|
|US8790359||May 18, 2007||Jul 29, 2014||Cybersonics, Inc.||Medical systems and related methods|
|US8814895||Jun 28, 2012||Aug 26, 2014||Ethicon Endo-Surgery, Inc.||Blades with functional balance asymmetries for use with ultrasonic surgical instruments|
|US8852166||Jun 20, 2012||Oct 7, 2014||Ekos Corporation||Ultrasonic catheter power control|
|US8932316||Apr 7, 2014||Jan 13, 2015||Broncus Medical Inc.||Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall|
|US20080051660 *||Aug 3, 2007||Feb 28, 2008||The University Of Houston System||Methods and apparatuses for medical imaging|
|US20100049209 *||Oct 1, 2009||Feb 25, 2010||Flowcardia, Inc.||Ultrasound catheter apparatus|
|US20120022393 *||Jul 19, 2011||Jan 26, 2012||Christian Pruckner||Medical treatment device|
|US20130131705 *||Nov 9, 2012||May 23, 2013||Olympus Medical Systems Corp.||Ultrasonic probe|
|CN100584285C||May 31, 2005||Jan 27, 2010||奥林巴斯株式会社;奥林巴斯医疗株式会社||Ultrasonic treatment implement, and probe for ultrasonic treatment implement|
|DE2626373A1 *||Jun 11, 1976||Jan 13, 1977||Fibra Sonics||Medizinisches geraet fuer chirurgische eingriffe und heilbehandlungseinrichtung mit ultraschallenergie|
|DE3247124A1 *||Dec 20, 1982||Oct 20, 1983||Go G Med Inst Im S M Kirova Go||Vorrichtung zur zerstoerung und aspiration von augengewebe|
|EP0229003A1 *||Nov 4, 1986||Jul 15, 1987||Swedemed AB||Ultrasonic aspirator|
|EP0238667A1 *||Jul 15, 1986||Sep 30, 1987||Sumitomo Bakelite Company Limited||Ultrasonic instrument for surgical operations|
|EP0316796A2 *||Nov 11, 1988||May 24, 1989||DonMichael, Anthony T.||Intravascular ultrasonic catheter probe for treating intravascular blockage|
|EP0401158A1 *||May 11, 1990||Dec 5, 1990||Schneider (Europe) Ag||Catheter apparatus with a guide wire and method for the production of such a guide wire|
|EP0514810A1 *||May 18, 1992||Nov 25, 1992||Rosa Antonio La||Ultrasonic dissector and detacher for atherosclerotic plaques|
|EP0627897A1 *||Jan 26, 1993||Dec 14, 1994||Angiosonics Inc.||Ultrasonic transmission apparatus|
|EP0784451A1 *||Oct 6, 1995||Jul 23, 1997||Misonix Inc.||Ultrasonic lipectomy probe and method for manufacture|
|EP0820727A2||May 4, 1993||Jan 28, 1998||Baxter International Inc.||Ultrasonic angioplasty catheter device|
|EP0820728A2||May 4, 1993||Jan 28, 1998||Baxter International Inc.||Ultrasonic angioplasty catheter device|
|EP0891744A1 *||Jan 26, 1993||Jan 20, 1999||Angiosonics Inc.||Ultrasonic transmission apparatus|
|EP1022985A1 *||Sep 29, 1998||Aug 2, 2000||Angiosonics Inc.||Lysis method and apparatus|
|EP1255495A1 *||Feb 2, 2001||Nov 13, 2002||Sound Surgical Technologies LLC||Ultrasonic cutting and coagulation knife using transverse vibrations|
|EP1570918A2 *||Feb 17, 2005||Sep 7, 2005||Air Products And Chemicals, Inc.||Transmission of ultrasonic energy into pressurized fluids|
|EP2417945A2||Mar 19, 2004||Feb 15, 2012||Flowcardia Inc.||Improved ultrasound catheter devices and methods|
|EP2471474A1||Feb 13, 2004||Jul 4, 2012||Flowcardia Inc.||Ultrasound catheter apparatus|
|EP2609878A1||Mar 19, 2004||Jul 3, 2013||FlowCardia, Inc.||Improved ultrasound catheter devices and methods|
|EP2636382A1 *||Feb 27, 2012||Sep 11, 2013||Olympus Medical Systems Corp.||Ultrasonic probe|
|WO1991012773A1 *||Feb 6, 1991||Sep 5, 1991||Devices Vascular Intervention||System and method for catheter construction|
|WO1992010140A1 *||Nov 27, 1991||Jun 25, 1992||Coraje Inc||Miniature ultrasonic transducer for plaque ablation and clot dissolution|
|WO1998030155A1 *||Jan 7, 1998||Jul 16, 1998||Frank Gminder||Handpiece for use with a multifunctional operating endoscopic instrument|
|WO2001024714A1 *||Sep 8, 2000||Apr 12, 2001||Ethicon Endo Surgery Inc||Multifunctional curved blade for use with an ultrasonic surgical instrument|
|WO2004018019A2||Aug 26, 2003||Mar 4, 2004||Flowcardia Inc||Ultrasound catheter for disrupting blood vessel obstructions|
|WO2004093736A2||Mar 19, 2004||Nov 4, 2004||Flowcardia Inc||Improved ultrasound catheter devices and methods|
|WO2005053769A2||Oct 25, 2004||Jun 16, 2005||Flowcardia Inc||Steerable ultrasound catheter|
|WO2006030563A1 *||May 31, 2005||Mar 23, 2006||Olympus Corp||Ultrasonic treatment implement, and probe, treatment section, and large-diameter section for ultrasonic treatment implement|
|WO2014062646A2 *||Oct 15, 2013||Apr 24, 2014||Med-Sonics Corporation||Apparatus and methods for transferring ultrasonic energy to a bodily tissue|
| || |
|U.S. Classification||606/159, 604/22, 601/4, 606/169|
|International Classification||A61B19/00, A61B18/00, A61B17/32, B06B3/00, B23Q1/00, A61B17/22, A61F7/00, A61M3/02, A61B17/00, B23Q5/027, A61M25/00|
|Cooperative Classification||A61B17/320068, A61B2017/32008, A61B2018/00011, A61F2007/0063, B23Q5/027, A61B2017/320072, A61B2017/22018, A61B2017/320096, A61M25/0069, B06B3/00, B23Q1/0027, A61M3/0279, A61B2017/00473, A61B17/22012|
|European Classification||A61M25/00T10A, A61B17/22B2, B23Q1/00B2B, A61B17/32U, B23Q5/027, B06B3/00|