|Publication number||US3444858 A|
|Publication date||May 20, 1969|
|Filing date||May 11, 1966|
|Priority date||May 14, 1965|
|Publication number||US 3444858 A, US 3444858A, US-A-3444858, US3444858 A, US3444858A|
|Inventors||Higham S Russell|
|Original Assignee||Higham S Russell|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (3), Referenced by (135), Classifications (13)|
|External Links: USPTO, USPTO Assignment, Espacenet|
y 1969 H. s. RUSSELL 3,444,858
METHOD AND MEANS FOR ADMINISTERING DRUGS Filed May 11. 1966 MFA/7'0? HGHAM STANLEY RUSS L ATTORNEY.
United States Patent 3,444,858 METHOD AND MEANS FOR ADMINISTERING DRUGS Higham S. Russell, 29 Camberley Drive, Rochdale, Lancashire, England Filed May 11, 1966, Ser. No. 549,381 Claims priority, application Great Britain, May 14, 1965, 20,377/ 65 Int. Cl. A61m 31/00; A6113 7/02; A611 15/00 US. Cl. 128260 Claims ABSTRACT OF THE DISCLOSURE A vehicle for administering a drug comprising an elongate sectionalized strip of resiliently flexible gelatinous material of a section which enables a length thereof conveniently to be inserted into the buccal sulcus so as to adhere to the gum thereat, the vehicle containing a drug having a capacity to be absorbed through the users buccal mucous membrane, the strip being so formed at intervals therealong as to facilitate its being subdivided to provide individual sections of a desired drug dosage.
This invention concerns a vehicle for administering drugs.
It is well known that various drugs, be they hormonal preparations or otherwise, are destroyed or inactivated by saliva in the mouth or fluids in the stomach if they are administeredfby way of the digestive tract, and certain drugs mayhave undesirable side effects when ad ministered orally. Therefore, such drugs are, where possible, injected into the body, but this procedure is not very convenient to adopt in many circumstances, there being well known risks in the giving of injections.
Other drugs capable of being administered orally are only very slightly absorbed into the body through the stomach. In these cases, massive overdoses have to be administered, and this, too, is not very satisfactory as the rate of absorption varies considerably from patient to patient and accurate forecast of optimum dosage cannot be made.
In certain instances drugs should desirably be administered gradually and progressively only until a desired effect is obtained, and this is difiicult to carry out with the means hitherto available.
An object of the invention is to provide a vehicle for administering drugs whereby the aforementioned difliculties are minimised, the vehicle providing for a particularly convenient, simple and accurate method of administration.
According to the present invention there is provided a vehicle for administering drugs, comprising an elongate strip of resiliently flexible gelatinous material of a section which enables a length thereof conveniently to be inserted in the buccal sulcus so as to adhere to the gum thereat, the vehicle containing a drug (preferably of a type which, if swallowed, would be destroyed or inactivated by saliva or fluids in the stomach, or would produce undesired side effects, or would require to be administered in massive overdoses), which is effective when absorbed through the buccal mucous membrane of a person, the said strip being marked or otherwise formed at intervals therealong to facilitate it being divided up to provide individual lengths of desired drug content or dosage.
The invention also provides a method of making a vehicle as aforesaid comprising the steps of preparing a liquid solution or melt of a gelatinous material, impregnating the solution or melt with the said drug and forming the impregnated solution or melt into the vehicle.
The vehicle is preferably of a form of glyco-gelatine 3,444,858 Patented May 20, 1969 which is sufliciently firm and solid to be resilient, and is conveniently in the form of an extrusion of rectangular or oval cross section.
In a preferred form the vehicle is impregnated with a drug of very potent nature as such drugs are usually effective even when administered in very small amounts eg in doses of a fraction of a milligram.
The invention will be described further, by way of example, with reference to the accompanying drawings, in which:
FIG. 1 is an enlarged perspective view showing part of a first embodiment of the vehicle of the invention;
FIG. 2 is a section corresponding to the line IIII of FIG. 1;
FIGS. 3, 4, 5, 6 and 7 are views similar to FIG. 2 but showing five suitable alternative cross-sections for the vehicle;
FIGS. 8 and 9 are views similar to FIG. 1 but showing two further embodiments of the vehicle;
FIG. 10 is a diagrammatic view showing a small length of the vehicle of FIGS. 1 and 2 in its position of use; and
FIG. 11 is a view similar to FIG. 10 but showing a longer length of the vehicle in use.
Referring firstly to FIGS. 1 and 2, a vehicle for administering drugs in conformity with the invention comprises an elongate strip 10, generally of rectangular crosssection and made of a resilient flexible gelatinous material such as glyco-gelatine. Contained in such material is a drug the nature of which will be discussed later. As can be seen, the strip 10 is formed at intervals therealong with pairs of transverse depressions 11 in opposite major faces thereof so as to divide the strip into a plurality of sections '12 which are each connected to the next adjacent sections by comparatively weak ligaments 13.
The purpose of these ligaments 13 is to enable the strip 10 to be torn or otherwise divided up into individual lengths each of which consists of one or a desired number of the sections 12.
FIG. 10 shows how the vehicle of FIGS. 1 and 2 may be used. A single section 12, after having been severed from the strip 10, is inserted into the buccal sulcus 14 at the front of a patients mouth and is pressed firmly against the gum 15 thereat. Because the material of the section 12 is flexible and resilient and the gum is usually slightly moist with saliva, the section 12 can be pressed to the gum 15 so as to substantially immediately adhere to the gum 15 at the upper part thereof, to occupy substantially wholly the upper part of the space defined by the transition between the gum 15 and the adjacent lip 16. As soon as it adheres in position, the section 12 immedi ately excludes saliva from that part of the gum 15 which it overlies, and access thereto of saliva from the rest of the mouth is minimised by the lip 16. At the face of the material abutting the gum 15, such material slowly goes into solution and is absorbed into the patients bloodstream through the gum 15, gradual dissolution of the material ensuring that there is a constant supply thereof available for absorption.
Assuming the vehicle 10 to have been produced so that each section 12 thereof contains a predetermined quantity of the drug, it will be evident that a desired dosage of the drug can be administered by the use of an appropriate number of the sections 12. Thus, whilst FIG. 10 shows a single section 12 in position for administration, a plurality thereof can be administered simultaneously as shown in FIG. 11, each of the sections 12 adhering to the gum 15 for absorption therethrough.
The vehicle 10 can be of any cross-section which is suitable for insertion into the buccal sulcus at the front of the users mouth and which will readily adhere to the gum thereat. Thus, it may be square in cross-section as is the case of the vehicle 10a of FIG. 3, it may be cir- 3 cular (vehicle 10b of FIG. 4), oval (vehicle 100 of FIG. 5), of thin strip form with its two major faces 17 and 18 respectively convex and concave (vehicle d of FIG.
6) or of thicker strip form with convex and concave faces.
19 and 20* respectively (vehicle Me of FIG. 7). When sections 12 of the latter two vehicles 10d and 10e are used, the concave surfaces 18, 20 are pressed against the gum 15.
In the case of the two vehicles 10d and 10e of FIGS. 6 and 7, the ligaments 13 are shown as having been defined by pairs of depressions 11 extending inwards from the opposite edges of the vehicle instead of from the opposite major faces 17, 18 and 19, 20. Naturally, it will be understood that these vehicles can be formed with depressions 11 similar to those of FIGS. 1 to 5 and conversely the vehicles of FIGS. 1 to 5 may have depressions similar to those of FIGS. 6 and 7. A vehicle 10 comparable to those of FIGS. 6 and 7 is shown in FIG. 8, the vehicle here being substantially flat strip form to provide fiat sections 12.
Elm all the forms of the vehicle so far described and illustrated, pairs of depressions 11 are provided at intervals along the strip, but it will be appreciated that the strip can equally well be divided or graduated into sections, preferably of equal sizes, by single depressions at intervals along the strip such depressions extending from edge to edge or from side to side of the strip, whereby the strip may readily be torn across, or extending only part of the way across the strip simply by way of graduations defining the individual sections 12 and providing appropriate indications for cutting the strip as desired, e.g. by use of scissors. Conversely, the strip can be marked or graduated by means of thickened ribs instead of depressions. Such a vehicle is illustrated at 10g in FIG. 9 wherein the vehicle is graduated in section 12 by ribs 21 extending from edge to edge of the strip on one face only thereof. These ribs 21 can, of course, extend only part of the way across the strip.
The vehicles as described can be made in any suitable manner whereby glyco-gelatine may be formed into strips, and the following exemplifies one way in which it may be carried out.
Firstly the desired drug is stirred, mixed or otherwise thoroughly dispersed into a batch of glyco-gelatine solution or melt, and such material is then run into a series of moulds each of which is shaped according to the desired strip from of the vehicle, the glyco-gelatine, with the drug contained therein, being hardened and dried whilst in the moulds to such a degree that the strips, upon being stripped from the moulds can conveniently be handled yet are resilient and flexible.
Alternatively, the material containing the drug may be appropriately extended in continuous strip form, the graduations, depressions, ribs or other markings being subsequently produced thereon, for example by passing the strip through a nip formed by a paid of heated rollers shaped to form the depressions thereon.
The following is an example of a suitable composition for the gelatinous material:
Percent by weight Gelatine B.P. 45.48 Glycerine B.P. 16.20 Water 38.32
Other glyco-gel'atine"based mixtures, or a gelatinous material based on the alginates, or other suitable (e.g. resin-based) material may be used, but a material based on glyco-gelatine is preferred. The material of the above described example will have a melting point near blood heat e.g. between 105 and F. and is soft and resiliently pliable at the temperature usual in the mouth. Furthermore, the material is virtually non-toxic and has no side effects on the patient; it is soluble in water, is almost tasteless, and is thus suitable for absorption through the mucous membrane of the gum, i.e. in the buccal sulcus. These properties or proportions similar thereto are necessary for any alternative material.
The drug incorporated in the vehicle of the invention will be present in a small quantity e.g. a few microgrammes or milligrammes of the drug per centimetre length of the vehicle. The drug may be of various types such as those which are usually injected or given rectally because they are:
(a) substantially destroyed or inactivated in the stomach or intestines, when ingested;
-(b) active in an unwanted manner upon the stomach or intestines to produce undesirable side effects when ingested;
(c) variable in absorption or eifect from patient to patient;
((1) slow to act when ingested so that they require massive overdoses to be effective; or
(e) of local application.
The principal types of drugs are as follows:
Type 1.-Hormones; their derivatives and analogues, such as the steroid hormones; and the polypeptide hormones e.g. vasopressin and insulin. Further examples are: oxytocin; testosterone; oestrogens, and progesterones.
Type 2.--Loca-l anaesthetics and the like e.g., ligno caine hydrochloride and diperodon hydrochloride.
Type 3.Sympathomimet-ic amines e.g., adrenaline, noradrenaline, isprenaline and amphetamine, and substances which have an opposing action such as ergotamine and dibenilene.
Type 4.--Substances to be given when a prompt response may be desirable, e.g. vasco-dilators; quick acting diuretics; analgesics e.g. morphine; and cardiovascular reactants e.g. glyceryl trinitrate.
Type 5.-Substances having an optimum dose not ascertainable before administration, e.g. oxytocin, digitalin, barbiturates, muscle relaxants and ganglion blocking agents.
Type 6.-Substances acting on the parasympathetic system, e.g. acetylcholine, anticholinesterases and physestigmine.
Type 7.Various other substances which are potent when absorbed, such as antihistamines, e.g. promethazine; alkaloids, and glycosides such as atropine and hyoscine; nitrates e.g. amyl nitrate; analeptics e.g. caffine and amphetamines; cytoatoxic agents; anticoagulants e.g. heparin; vitamins such as cyanocobalamin; and trace element substances.
Type 8.Metabolic reactants for clincal investigations e.g. para-amino-hippuric acid.
It is possible to use any drug which is sufliciently stable, potent, and absorbable. A good example is insulin even though it has a substantial molecular weight.
In use when it is desired to administer a given amount of the drug, an appropriate length of the vehicle is severed from the strip and the severed length is inserted into the buccal su'lcus as described. It is thereafter entirely absorbed into the gum or is allowed to be absorbed until the desired effect is obtained.
Due to the fact that the vehicle is, eflectively, a solution of the drug in a gelatinous material, the rate of absorption is remarkably constant, especially when compared with the absorption rates of a tablet of compressed particulate material having a similar overall concentra= tion of the dr g, but having a par iculate character.
Furthermore, the vehicle does not fragment and therefore may be easily removed when suflicient of the drug has been absorbed, and the cut length will be readily retained in the sulcus due to its semi-plastic nature. Since the severed length of the vehicle is entirely contained within the buccal sulcus little or none of the drug need be Washed away or inactivated by saliva, and since the vehicle is hardly felt when in place it does not provoke salivation. Furthermore, the vehicle is located away from the flow path of any saliva which may be secreted.
The length of the vehicle, being severed from a strip, may be chosen so as to facilitate the administration of an exact and chosen amount ofthe drug.
Due to its adhesive properties and to the fact that the severed lengths of the vehicle tends to adopt the shape of the sulcus after a very short time, the patient can talk, eat, smoke, drink and cough without any fear of ingesting or swallowing the vehicle.
In one particular application and embodiment the vehicles are impregnated with oxytocin, a drug which is used to induce labour in pregnancy. It will be readily appreciated that the vehicle and method described offer a further advantage, in this particular application, in that oxytocin is usually administered as an intravenous drip which is extremely inconvenient during the wait for labour to begin. The vehicle obviates the need for an intravenous drip, and can be removed as soon as the required degree of muscular contractions are evident. Thus the risk of rupturing the uterus may be substantially reduced. In this case should the vehicle be swallowed the drug will become inactivated by the stomach and no damage will advertently ensue. The vehicle also obviates some disadvantages which are inherent in compressed pulverulent tablets, e.g. such tablets are often uncomfortable and make their presence felt in the mouth and thus stimulate salivation, such salivation causing the substance to be washed away and sometimes inactivated. Therefore, the vehicle may contain a smaller dosage than a comparable tablet and yet be just as effective. Furthermore, the vehicle is absorbed in a more regular manner and absorption peaks, and the corresponding over reactions by the patient, are avoided.
Type 2 substances, i.e. local anaesthetics, are particularly suitable for use in dentistry, and the vehicle for such use may also include antibiotics and haemostatic substances, the vehicle being superimposed upon the gum adjacent the tooth to be treated or removed, to deaden the pain of injections and the subsequent operations.
The invention is not confined to the precise details of the foregoing example and many variations are possible.
For instance an absorbable preparation may be incorporated into vehicles and administered by the method of this invention, which is particularly suitable for the administration of drugs which vary in potency according to the condition of the patient, as the vehicle may be removed when sufficient of the drug has been absorbed.
The vehicle may be prepared by any suitable means and from any suitable flexible or gelatinous material, and, in the stance wherein the material comprises mainly glyco-gelatine, various plasticisors and diluents may be incorporated, not only to improve and/ or vary the qualities of the vehicle, but also to facilitate the production thereof, and the incorporation of the drug or drugs thereinto. Also, the vehicle may be formed, provided with a protective coating and marker linearly in a continuous operation. The vehicle may have any suitable cross-section but the cross-section should be of a size and shape commensurate with the size of the buccal sulcus of an average person. It is possible also to form smaller dimensioned vehicles suitable for treating children. Any coating provided on the vehicle may be of a type which must be removed before use, or a saliva soluble coating may be used, the vehicle being moistened with saliva before insertion into the buccal sulcus. It is also possible to embody in the vehicle a drug suitable for administration to animals.
1. A vehicle for administering a drug comprising: an elongate sectionalized strip for resiliently flexible gelatinous material enabling a desired length thereof conveniently to be inserted into the buccal sulcus for adherence to the gum thereat and containing a drug absorbable through a users buccal mucous membrane, the said strip being formed at intervals therealong to facilitate it being subdivided for providing individual sections of a desired drug dosage, with the strip being formed at intervals therealong with depressions extending transversely of the strip and dividing the latter into a plurality of sections each being connected to the next adjacent sections by readily tearable ligaments.
2. A vehicle as claimed in claim 1 wherein the strip is of oval or circular cross-section.
3. A vehicle as claimed in claim 1 where in the strip is of a form having two opposite and respectively concave and convex faces.
4. A vehicle as claimed in claim 1 with the strip being formed at intervals along one major surface thereof with ribs dividing the strip into plurality of sections.
5. A vehicle as claimed in claim 1 with the material of the vehicle being glyco-gelatine.
References Cited UNITED STATES PATENTS 2,068,703 1/1937 Powderrnaker '128-l55 X 2,764,501 9/1956 Perri 128--l56 X 3,249,109 5/1966 Maeth et a1 128268 ADELE M. EAGER, Primary Examiner.
U.S. Cl. X.R.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2068703 *||May 25, 1935||Jan 26, 1937||Powdermaker Frank||Bandage|
|US2764501 *||Jun 18, 1953||Sep 25, 1956||Perri Myrtle Sangree||Supply of pressure-sensitive reinforcements for paper and the like|
|US3249109 *||Nov 1, 1963||May 3, 1966||Maeth Harry||Topical dressing|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3598123 *||Apr 1, 1969||Aug 10, 1971||Alza Corp||Bandage for administering drugs|
|US3696811 *||Jun 17, 1971||Oct 10, 1972||Squibb & Sons Inc||Periodontal bandage and backing therefor|
|US3698392 *||Apr 21, 1971||Oct 17, 1972||Kewanee Oil Co||Topical dressing|
|US3731683 *||Jun 4, 1971||May 8, 1973||Alza Corp||Bandage for the controlled metering of topical drugs to the skin|
|US3797496 *||May 6, 1972||Mar 19, 1974||Physio Medics Inc||Post-extraction pads|
|US3960150 *||Sep 15, 1975||Jun 1, 1976||Alza Corporation||Bioerodible ocular device|
|US3972995 *||Apr 14, 1975||Aug 3, 1976||American Home Products Corporation||Dosage form|
|US3981303 *||Jul 31, 1975||Sep 21, 1976||Alza Corporation||Bioerodible ocular device|
|US3986510 *||Aug 1, 1975||Oct 19, 1976||Alza Corporation||Bioerodible ocular device|
|US3991760 *||Dec 2, 1975||Nov 16, 1976||The Procter & Gamble Company||Vaginal medicament dispensing means|
|US3993071 *||Jul 24, 1975||Nov 23, 1976||Alza Corporation||Bioerodible ocular device|
|US3993073 *||Mar 3, 1975||Nov 23, 1976||Alza Corporation||Novel drug delivery device|
|US3995633 *||Dec 2, 1975||Dec 7, 1976||The Procter & Gamble Company||Vaginal Medicament dispensing device|
|US4020558 *||Jul 21, 1975||May 3, 1977||Societe Sodermec||Buccal implant for administering solubilizable products|
|US4039653 *||Jul 21, 1975||Aug 2, 1977||Defoney, Brenman, Mayes & Baron||Long-acting articles for oral delivery and process|
|US4292299 *||Jul 7, 1980||Sep 29, 1981||Teijin Limited||Slow-releasing medical preparation to be administered by adhering to a wet mucous surface|
|US4451260 *||Mar 26, 1982||May 29, 1984||Minnesota Mining And Manufacturing Company||Sustained release oral medicinal delivery device|
|US4470962 *||Apr 28, 1981||Sep 11, 1984||Key Pharmaceuticals, Inc.||Polymeric diffusion matrix|
|US4482533 *||Mar 28, 1983||Nov 13, 1984||Key Pharmaceuticals, Inc.||Polymeric diffusion matrix containing propranolol|
|US4529589 *||Sep 29, 1983||Jul 16, 1985||Davydov Anatoly B||Pharmaceutical composition for the treatment of diabetes mellitus|
|US4568536 *||Feb 8, 1985||Feb 4, 1986||Ethicon, Inc.||Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition|
|US4647448 *||Dec 21, 1984||Mar 3, 1987||Smith Kline & French Laboratories Limited||Pharmaceutical dosage unit|
|US4713239 *||Nov 19, 1985||Dec 15, 1987||Vsesojuny Kardiologichesky Nauchny Tsentr Adkaemii Meditsinski Nauk Sssr||Antianginal film and method of treating ischemic heart disease|
|US4764378 *||Feb 10, 1986||Aug 16, 1988||Zetachron, Inc.||Buccal drug dosage form|
|US4842854 *||May 13, 1987||Jun 27, 1989||Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskiki Nauk Ssr||Antianginal plate for treating ischemic heart disease|
|US4849246 *||Oct 7, 1986||Jul 18, 1989||Wolfgang Schmidt||Process for producing an administration or dosage form for drugs, reagents or other active ingredients|
|US4921695 *||Mar 9, 1989||May 1, 1990||Babaian Eduard A||Antianginal plate for treating ischemic heart disease|
|US5484602 *||Jan 20, 1995||Jan 16, 1996||University Of Utah Research Foundation||Methods and compositions for noninvasive dose-to-effect administration of drugs with cardiovascular or renal vascular activities|
|US6264974||Jul 7, 1998||Jul 24, 2001||Salvagnini Italia Spa||Buccal and sublingual administration of physostigmine|
|US6596298||Sep 14, 1999||Jul 22, 2003||Warner-Lambert Company||Fast dissolving orally comsumable films|
|US6659442||Jan 29, 1999||Dec 9, 2003||Lts Lohamann Therapie-Systeme Ag||Method and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile|
|US6682756||Nov 21, 1997||Jan 27, 2004||Lts Lohmann Therapie-Systeme Ag||Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance|
|US6800329 *||Dec 9, 2002||Oct 5, 2004||Lts Lohmann Therapie-Systeme Ag||Method for producing film-type dosage|
|US6923981||Apr 17, 2003||Aug 2, 2005||Warner-Lambert Company||Fast dissolving orally consumable films|
|US7025983||Apr 18, 2001||Apr 11, 2006||Warner-Lambert Company Llc||Fast dissolving orally consumable films|
|US7067116||Mar 23, 2000||Jun 27, 2006||Warner-Lambert Company Llc||Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1|
|US7175172 *||Sep 9, 2003||Feb 13, 2007||Lts Lohmann Therapie-Systeme Ag||Method and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile|
|US7232500||Jan 15, 2003||Jun 19, 2007||Lts Lohmann Therapie-Systeme Ag||Method and device for producing products in web form|
|US7357891||Jan 30, 2004||Apr 15, 2008||Monosol Rx, Llc||Process for making an ingestible film|
|US7407669||Oct 14, 2003||Aug 5, 2008||Mcneil-Ppc, Inc.||Fast dissolving orally consumable films|
|US7425292||Feb 14, 2002||Sep 16, 2008||Monosol Rx, Llc||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US7491406||Oct 13, 2005||Feb 17, 2009||Mcneil-Ppc, Inc.||Fast dissolving orally consumable films|
|US7648712||May 5, 2006||Jan 19, 2010||Mcneil-Ppc, Inc.||Fast dissolving orally consumable films containing a taste masking agent|
|US7666337||May 28, 2004||Feb 23, 2010||Monosol Rx, Llc||Polyethylene oxide-based films and drug delivery systems made therefrom|
|US7824588||Apr 14, 2008||Nov 2, 2010||Monosol Rx, Llc||Method of making self-supporting therapeutic active-containing film|
|US7910641||Dec 14, 2006||Mar 22, 2011||Monosol Rx, Llc||PH modulated films for delivery of actives|
|US7972618||Sep 20, 2007||Jul 5, 2011||Monosol Rx, Llc||Edible water-soluble film containing a foam reducing flavoring agent|
|US8017150||Apr 22, 2008||Sep 13, 2011||Monosol Rx, Llc||Polyethylene oxide-based films and drug delivery systems made therefrom|
|US8357114||Jan 5, 2007||Jan 22, 2013||Acelrx Pharmaceuticals, Inc.||Drug dispensing device with flexible push rod|
|US8475832||Aug 7, 2009||Jul 2, 2013||Rb Pharmaceuticals Limited||Sublingual and buccal film compositions|
|US8499966||Dec 28, 2007||Aug 6, 2013||Acelrx Pharmaceuticals, Inc.||Method of moving a delivery member of a dispensing device for administration of oral transmucosal dosage forms|
|US8535714||Oct 18, 2011||Sep 17, 2013||Acelrx Pharmaceuticals, Inc.||Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain|
|US8548623||Mar 16, 2010||Oct 1, 2013||Acelrx Pharmaceuticals, Inc.||Storage and dispensing devices for administration of oral transmucosal dosage forms|
|US8574189||Mar 9, 2012||Nov 5, 2013||Acelrx Pharmaceuticals, Inc.||Storage and dispensing devices for administration of oral transmucosal dosage forms|
|US8603514||Jul 10, 2007||Dec 10, 2013||Monosol Rx, Llc||Uniform films for rapid dissolve dosage form incorporating taste-masking compositions|
|US8652378||Mar 29, 2013||Feb 18, 2014||Monosol Rx Llc||Uniform films for rapid dissolve dosage form incorporating taste-masking compositions|
|US8663687||May 13, 2010||Mar 4, 2014||Monosol Rx, Llc||Film compositions for delivery of actives|
|US8685437||Mar 26, 2009||Apr 1, 2014||Monosol Rx, Llc||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US8753308||Nov 15, 2012||Jun 17, 2014||Acelrx Pharmaceuticals, Inc.||Methods for administering small volume oral transmucosal dosage forms using a dispensing device|
|US8758803||Apr 30, 2009||Jun 24, 2014||Lts Lohmann Therapie-Systeme Ag||Film-shaped preparation comprising oily substances for oral administration|
|US8765167||Sep 8, 2006||Jul 1, 2014||Monosol Rx, Llc||Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions|
|US8778393||Jul 23, 2012||Jul 15, 2014||Acelrx Pharmaceuticals, Inc.||Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain|
|US8778394||Jul 30, 2012||Jul 15, 2014||Acelrx Pharmaceuticals, Inc.||Small-volume oral transmucosal dosage forms|
|US8865211||Aug 27, 2012||Oct 21, 2014||Acelrx Pharmaceuticals, Inc.||Bioadhesive drug formulations for oral transmucosal delivery|
|US8865743||Nov 14, 2007||Oct 21, 2014||Acelrx Pharmaceuticals, Inc.||Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain|
|US8883191||Dec 26, 2003||Nov 11, 2014||Lts Lohmann Therapie-Systeme Ag||Method for producing individually dosed active substance-containing and, in particular, aromatics-containing film-shaped administration forms rapidly disintegrating upon contact with liquid|
|US8900497||Aug 23, 2013||Dec 2, 2014||Monosol Rx, Llc||Process for making a film having a substantially uniform distribution of components|
|US8900498||Aug 23, 2013||Dec 2, 2014||Monosol Rx, Llc||Process for manufacturing a resulting multi-layer pharmaceutical film|
|US8905964||Jan 18, 2013||Dec 9, 2014||Acelrx Pharmaceuticals, Inc.||Drug storage and dispensing devices and systems comprising the same|
|US8906277||Aug 23, 2013||Dec 9, 2014||Monosol Rx, Llc||Process for manufacturing a resulting pharmaceutical film|
|US8945592||Nov 21, 2008||Feb 3, 2015||Acelrx Pharmaceuticals, Inc.||Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same|
|US8974826||Jun 10, 2011||Mar 10, 2015||Monosol Rx, Llc||Nanoparticle film delivery systems|
|US9066847||Jul 3, 2007||Jun 30, 2015||Aceirx Pharmaceuticals, Inc.||Storage and dispensing devices for administration of oral transmucosal dosage forms|
|US9108340||Aug 23, 2013||Aug 18, 2015||Monosol Rx, Llc||Process for manufacturing a resulting multi-layer pharmaceutical film|
|US9265779||Apr 30, 2014||Feb 23, 2016||Lts Lohmann Therapie-Systeme Ag||Method of using a film-shaped preparation comprising oily substances for oral administration|
|US9289583||Oct 30, 2007||Mar 22, 2016||Acelrx Pharmaceuticals, Inc.||Methods for administering small volume oral transmucosal dosage forms using a dispensing device|
|US9320710||Oct 17, 2014||Apr 26, 2016||Acelrx Pharmaceuticals, Inc.||Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain|
|US9545376||Jan 23, 2014||Jan 17, 2017||Arx, Llc||Production of unit dose constructs|
|US9554976||Jul 30, 2013||Jan 31, 2017||The Procter & Gamble Company||Tooth whitening product|
|US20010022964 *||Apr 18, 2001||Sep 20, 2001||Leung Sau-Hung S.||Fast dissolving orally consumable films|
|US20030107149 *||Feb 14, 2002||Jun 12, 2003||International Fluidics.||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20030206942 *||Apr 25, 2003||Nov 6, 2003||Neema Kulkarni||Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent|
|US20030211136 *||Apr 25, 2003||Nov 13, 2003||Neema Kulkarni||Fast dissolving orally consumable films containing a sweetener|
|US20030219388 *||Jun 19, 2003||Nov 27, 2003||Christian Kropf||Remineralizing dental adhesive film|
|US20040046305 *||Sep 9, 2003||Mar 11, 2004||Lts Lohmann Therapie-Systeme Ag||Method and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile|
|US20040122065 *||Nov 3, 2003||Jun 24, 2004||Lerner E. Itzhak||Pharmaceutical compositions and dosage forms for buccal and sublingual delivery of tizanidine and methods of administering tizanidine sublingually or buccally|
|US20040136922 *||Oct 14, 2003||Jul 15, 2004||Leung Sau-Hung Spence||Fast dissolving orally consumable films|
|US20040137027 *||Dec 26, 2003||Jul 15, 2004||Michael Horstmann||Method for producing individually dosed active substance-containing and, in particular, aromatics-containing film-shaped administration forms rapidly disintegrating upon contact with liquid|
|US20040178218 *||Jun 13, 2002||Sep 16, 2004||Jurgen Schomakers||Dosing stick containing rod-shaped tablets|
|US20040247648 *||May 3, 2004||Dec 9, 2004||Fadden David John||Fast dissolving orally consumable films containing a modified starch for improved heat and moisture resistance|
|US20040258896 *||Jan 30, 2004||Dec 23, 2004||Monosolrx Llc.||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20050031675 *||Sep 15, 2004||Feb 10, 2005||Sau-Hung Spence Leung||Fast dissolving orally consumable film|
|US20050095363 *||Jan 15, 2003||May 5, 2005||Detlev Neuland||Method and device for producing products in web form|
|US20050109788 *||Oct 27, 2004||May 26, 2005||Steven Catani||Dispensing device for solid sweetener|
|US20050184427 *||Mar 29, 2005||Aug 25, 2005||Monosolrx, Llc.||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20050238591 *||Jun 21, 2005||Oct 27, 2005||Sagel Paul A||Tooth whitening substances|
|US20060039953 *||Oct 13, 2005||Feb 23, 2006||Leung Sau-Hung S||Fast dissolving orally consumable films|
|US20060039958 *||Sep 28, 2005||Feb 23, 2006||Monosolrx, Llc.||Multi-layer films having uniform content|
|US20060147493 *||Jul 22, 2003||Jul 6, 2006||Yang Robert K||Packaging and dispensing of rapid dissolve dosage form|
|US20060204559 *||May 5, 2006||Sep 14, 2006||Bess William S||Fast dissolving orally consumable films containing an ion exchange resin as a taste masking agent|
|US20070069416 *||Jun 22, 2006||Mar 29, 2007||Monosolrx, Llc||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20070122455 *||Sep 8, 2006||May 31, 2007||Monosolrx, Llc.||Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions|
|US20070149731 *||Dec 14, 2006||Jun 28, 2007||Monosolrx, Llc.||PH modulated films for delivery of actives|
|US20070154527 *||Dec 5, 2006||Jul 5, 2007||Monosoirx, Llc||Topical film compositions for delivery of actives|
|US20070172515 *||Jan 19, 2007||Jul 26, 2007||Monosolrx, Llc||Film bandage for mucosal administration of actives|
|US20070186923 *||Jan 5, 2007||Aug 16, 2007||Aceirx Pharmaceuticals, Inc.||Drug storage and dispensing devices and systems comprising the same|
|US20070190157 *||Jan 19, 2007||Aug 16, 2007||Monosoirx, Llc.||Film lined packaging and method of making same|
|US20070281003 *||Feb 13, 2007||Dec 6, 2007||Fuisz Richard C||Polymer-Based Films and Drug Delivery Systems Made Therefrom|
|US20070293580 *||Jun 5, 2007||Dec 20, 2007||Malcolm Hill||Methods for Buccal, Lingual or Sublingual Dosing Regimens of Epinephrine for the Treatment of Allergic Emergencies|
|US20070293581 *||Jun 5, 2007||Dec 20, 2007||Malcolm Hill||Methods for Buccal, Lingual or Sublingual Dosing Regimens of Epinephrine for the Treatment of Allergic Emergencies|
|US20070293582 *||Jun 5, 2007||Dec 20, 2007||Malcolm Hill||Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms|
|US20080020024 *||Aug 29, 2007||Jan 24, 2008||Neema Kulkarni||Fast dissolving orally consumable films|
|US20080025927 *||Jul 31, 2007||Jan 31, 2008||Sagel Paul A||Delivery system for an oral care substance|
|US20080044454 *||Jul 10, 2007||Feb 21, 2008||Monosolrx Llc||Uniform films for rapid dissolve dosage form incorporating taste-masking compositions|
|US20080075825 *||Sep 20, 2007||Mar 27, 2008||Fuisz Richard C||Edible Water-Soluble Film Containing a Foam Reducing Flavoring Agent|
|US20080081071 *||Sep 28, 2007||Apr 3, 2008||Pradeep Sanghvi||Film Embedded Packaging and Method of Making Same|
|US20080147044 *||Oct 30, 2007||Jun 19, 2008||Acelrx Pharmaceuticals, Inc.||Methods for administering small volume oral transmucosal dosage forms using a dispensing device|
|US20080260805 *||Apr 14, 2008||Oct 23, 2008||Monosol Rx, Llc||Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom|
|US20080260809 *||Apr 22, 2008||Oct 23, 2008||Monosol Rx, Llc||Polyethylene oxide-based films and drug delivery systems made therefrom|
|US20080268023 *||Nov 14, 2007||Oct 30, 2008||Acelrx Pharmaceuticals, Inc.||Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain|
|US20090048237 *||Aug 7, 2008||Feb 19, 2009||Acelrx Pharmaceuticals, Inc.||Compositions and methods for procedural sedation and analgesia using oral transmucosal dosage forms|
|US20100021526 *||Oct 7, 2009||Jan 28, 2010||Monosol Rx, Llc||Ph modulated films for delivery of actives|
|US20100130551 *||Nov 21, 2008||May 27, 2010||Acelrx Pharmaceuticals, Inc.||Sufentanil Solid Dosage Forms Comprising Oxygen Scavengers and Methods of Using the Same|
|US20100137836 *||Dec 28, 2007||Jun 3, 2010||Acelrx Pharmaceuticals, Inc.||Storage and Dispensing Devices for Administration of Oral Transmucosal Dosage Forms|
|US20110033541 *||Aug 7, 2009||Feb 10, 2011||Monosol Rx, Llc||Sublingual and buccal film compositions|
|US20110033542 *||Aug 7, 2009||Feb 10, 2011||Monosol Rx, Llc||Sublingual and buccal film compositions|
|US20110091544 *||Oct 16, 2009||Apr 21, 2011||Acelrx Pharmaceuticals, Inc.||Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting|
|USRE37382||Dec 10, 1998||Sep 18, 2001||Alayne Yates||Gum pad for mucosal delivery of medication|
|USRE42126||Jun 30, 2000||Feb 8, 2011||The Procter & Gamble Company||Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip|
|DE2656387A1 *||Dec 13, 1976||Jun 30, 1977||Hoffmann La Roche||Feste pharmazeutische einheitsdosierungsform als darreichunsform eines medikaments sowie verfahren und anlage zu ihrer herstellung|
|DE4217102A1 *||May 22, 1992||Nov 25, 1993||Winand Neuhausen||U-shaped mouth insert fitting between upper and lower teeth - releasing gas vapour or odour to mask or neutralise mouth odour|
|DE102008023345A1||May 13, 2008||Nov 19, 2009||Lts Lohmann Therapie-Systeme Ag||Filmförmige Zubereitung mit öligen Substanzen zur oralen Verabreichung|
|EP0157909A1 *||Mar 10, 1982||Oct 16, 1985||MERCK PATENT GmbH||Corpuscules containing medicaments|
|WO1982003174A1 *||Mar 10, 1982||Sep 30, 1982||Haerle Anton||Corpuscles containing drugs and use thereof in medecine and surgery|
|WO2002102296A1 *||Jun 13, 2002||Dec 27, 2002||Schomakers Juergen||Dosing stick containing rod-shaped tablets|
|U.S. Classification||604/77, 206/438, 206/820|
|International Classification||A61J7/00, A61J3/10, A61M35/00|
|Cooperative Classification||A61M35/00, A61J7/0092, A61J3/10, Y10S206/82|
|European Classification||A61J3/10, A61J7/00G, A61M35/00|