Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.


  1. Advanced Patent Search
Publication numberUS3444858 A
Publication typeGrant
Publication dateMay 20, 1969
Filing dateMay 11, 1966
Priority dateMay 14, 1965
Publication numberUS 3444858 A, US 3444858A, US-A-3444858, US3444858 A, US3444858A
InventorsHigham S Russell
Original AssigneeHigham S Russell
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Method and means for administering drugs
US 3444858 A
Abstract  available in
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

y 1969 H. s. RUSSELL 3,444,858


United States Patent 3,444,858 METHOD AND MEANS FOR ADMINISTERING DRUGS Higham S. Russell, 29 Camberley Drive, Rochdale, Lancashire, England Filed May 11, 1966, Ser. No. 549,381 Claims priority, application Great Britain, May 14, 1965, 20,377/ 65 Int. Cl. A61m 31/00; A6113 7/02; A611 15/00 US. Cl. 128260 Claims ABSTRACT OF THE DISCLOSURE A vehicle for administering a drug comprising an elongate sectionalized strip of resiliently flexible gelatinous material of a section which enables a length thereof conveniently to be inserted into the buccal sulcus so as to adhere to the gum thereat, the vehicle containing a drug having a capacity to be absorbed through the users buccal mucous membrane, the strip being so formed at intervals therealong as to facilitate its being subdivided to provide individual sections of a desired drug dosage.

This invention concerns a vehicle for administering drugs.

It is well known that various drugs, be they hormonal preparations or otherwise, are destroyed or inactivated by saliva in the mouth or fluids in the stomach if they are administeredfby way of the digestive tract, and certain drugs mayhave undesirable side effects when ad ministered orally. Therefore, such drugs are, where possible, injected into the body, but this procedure is not very convenient to adopt in many circumstances, there being well known risks in the giving of injections.

Other drugs capable of being administered orally are only very slightly absorbed into the body through the stomach. In these cases, massive overdoses have to be administered, and this, too, is not very satisfactory as the rate of absorption varies considerably from patient to patient and accurate forecast of optimum dosage cannot be made.

In certain instances drugs should desirably be administered gradually and progressively only until a desired effect is obtained, and this is difiicult to carry out with the means hitherto available.

An object of the invention is to provide a vehicle for administering drugs whereby the aforementioned difliculties are minimised, the vehicle providing for a particularly convenient, simple and accurate method of administration.

According to the present invention there is provided a vehicle for administering drugs, comprising an elongate strip of resiliently flexible gelatinous material of a section which enables a length thereof conveniently to be inserted in the buccal sulcus so as to adhere to the gum thereat, the vehicle containing a drug (preferably of a type which, if swallowed, would be destroyed or inactivated by saliva or fluids in the stomach, or would produce undesired side effects, or would require to be administered in massive overdoses), which is effective when absorbed through the buccal mucous membrane of a person, the said strip being marked or otherwise formed at intervals therealong to facilitate it being divided up to provide individual lengths of desired drug content or dosage.

The invention also provides a method of making a vehicle as aforesaid comprising the steps of preparing a liquid solution or melt of a gelatinous material, impregnating the solution or melt with the said drug and forming the impregnated solution or melt into the vehicle.

The vehicle is preferably of a form of glyco-gelatine 3,444,858 Patented May 20, 1969 which is sufliciently firm and solid to be resilient, and is conveniently in the form of an extrusion of rectangular or oval cross section.

In a preferred form the vehicle is impregnated with a drug of very potent nature as such drugs are usually effective even when administered in very small amounts eg in doses of a fraction of a milligram.

The invention will be described further, by way of example, with reference to the accompanying drawings, in which:

FIG. 1 is an enlarged perspective view showing part of a first embodiment of the vehicle of the invention;

FIG. 2 is a section corresponding to the line IIII of FIG. 1;

FIGS. 3, 4, 5, 6 and 7 are views similar to FIG. 2 but showing five suitable alternative cross-sections for the vehicle;

FIGS. 8 and 9 are views similar to FIG. 1 but showing two further embodiments of the vehicle;

FIG. 10 is a diagrammatic view showing a small length of the vehicle of FIGS. 1 and 2 in its position of use; and

FIG. 11 is a view similar to FIG. 10 but showing a longer length of the vehicle in use.

Referring firstly to FIGS. 1 and 2, a vehicle for administering drugs in conformity with the invention comprises an elongate strip 10, generally of rectangular crosssection and made of a resilient flexible gelatinous material such as glyco-gelatine. Contained in such material is a drug the nature of which will be discussed later. As can be seen, the strip 10 is formed at intervals therealong with pairs of transverse depressions 11 in opposite major faces thereof so as to divide the strip into a plurality of sections '12 which are each connected to the next adjacent sections by comparatively weak ligaments 13.

The purpose of these ligaments 13 is to enable the strip 10 to be torn or otherwise divided up into individual lengths each of which consists of one or a desired number of the sections 12.

FIG. 10 shows how the vehicle of FIGS. 1 and 2 may be used. A single section 12, after having been severed from the strip 10, is inserted into the buccal sulcus 14 at the front of a patients mouth and is pressed firmly against the gum 15 thereat. Because the material of the section 12 is flexible and resilient and the gum is usually slightly moist with saliva, the section 12 can be pressed to the gum 15 so as to substantially immediately adhere to the gum 15 at the upper part thereof, to occupy substantially wholly the upper part of the space defined by the transition between the gum 15 and the adjacent lip 16. As soon as it adheres in position, the section 12 immedi ately excludes saliva from that part of the gum 15 which it overlies, and access thereto of saliva from the rest of the mouth is minimised by the lip 16. At the face of the material abutting the gum 15, such material slowly goes into solution and is absorbed into the patients bloodstream through the gum 15, gradual dissolution of the material ensuring that there is a constant supply thereof available for absorption.

Assuming the vehicle 10 to have been produced so that each section 12 thereof contains a predetermined quantity of the drug, it will be evident that a desired dosage of the drug can be administered by the use of an appropriate number of the sections 12. Thus, whilst FIG. 10 shows a single section 12 in position for administration, a plurality thereof can be administered simultaneously as shown in FIG. 11, each of the sections 12 adhering to the gum 15 for absorption therethrough.

The vehicle 10 can be of any cross-section which is suitable for insertion into the buccal sulcus at the front of the users mouth and which will readily adhere to the gum thereat. Thus, it may be square in cross-section as is the case of the vehicle 10a of FIG. 3, it may be cir- 3 cular (vehicle 10b of FIG. 4), oval (vehicle 100 of FIG. 5), of thin strip form with its two major faces 17 and 18 respectively convex and concave (vehicle d of FIG.

6) or of thicker strip form with convex and concave faces.

19 and 20* respectively (vehicle Me of FIG. 7). When sections 12 of the latter two vehicles 10d and 10e are used, the concave surfaces 18, 20 are pressed against the gum 15.

In the case of the two vehicles 10d and 10e of FIGS. 6 and 7, the ligaments 13 are shown as having been defined by pairs of depressions 11 extending inwards from the opposite edges of the vehicle instead of from the opposite major faces 17, 18 and 19, 20. Naturally, it will be understood that these vehicles can be formed with depressions 11 similar to those of FIGS. 1 to 5 and conversely the vehicles of FIGS. 1 to 5 may have depressions similar to those of FIGS. 6 and 7. A vehicle 10 comparable to those of FIGS. 6 and 7 is shown in FIG. 8, the vehicle here being substantially flat strip form to provide fiat sections 12.

Elm all the forms of the vehicle so far described and illustrated, pairs of depressions 11 are provided at intervals along the strip, but it will be appreciated that the strip can equally well be divided or graduated into sections, preferably of equal sizes, by single depressions at intervals along the strip such depressions extending from edge to edge or from side to side of the strip, whereby the strip may readily be torn across, or extending only part of the way across the strip simply by way of graduations defining the individual sections 12 and providing appropriate indications for cutting the strip as desired, e.g. by use of scissors. Conversely, the strip can be marked or graduated by means of thickened ribs instead of depressions. Such a vehicle is illustrated at 10g in FIG. 9 wherein the vehicle is graduated in section 12 by ribs 21 extending from edge to edge of the strip on one face only thereof. These ribs 21 can, of course, extend only part of the way across the strip.

The vehicles as described can be made in any suitable manner whereby glyco-gelatine may be formed into strips, and the following exemplifies one way in which it may be carried out.

Firstly the desired drug is stirred, mixed or otherwise thoroughly dispersed into a batch of glyco-gelatine solution or melt, and such material is then run into a series of moulds each of which is shaped according to the desired strip from of the vehicle, the glyco-gelatine, with the drug contained therein, being hardened and dried whilst in the moulds to such a degree that the strips, upon being stripped from the moulds can conveniently be handled yet are resilient and flexible.

Alternatively, the material containing the drug may be appropriately extended in continuous strip form, the graduations, depressions, ribs or other markings being subsequently produced thereon, for example by passing the strip through a nip formed by a paid of heated rollers shaped to form the depressions thereon.

The following is an example of a suitable composition for the gelatinous material:

Percent by weight Gelatine B.P. 45.48 Glycerine B.P. 16.20 Water 38.32

Other glyco-gel'atine"based mixtures, or a gelatinous material based on the alginates, or other suitable (e.g. resin-based) material may be used, but a material based on glyco-gelatine is preferred. The material of the above described example will have a melting point near blood heat e.g. between 105 and F. and is soft and resiliently pliable at the temperature usual in the mouth. Furthermore, the material is virtually non-toxic and has no side effects on the patient; it is soluble in water, is almost tasteless, and is thus suitable for absorption through the mucous membrane of the gum, i.e. in the buccal sulcus. These properties or proportions similar thereto are necessary for any alternative material.

The drug incorporated in the vehicle of the invention will be present in a small quantity e.g. a few microgrammes or milligrammes of the drug per centimetre length of the vehicle. The drug may be of various types such as those which are usually injected or given rectally because they are:

(a) substantially destroyed or inactivated in the stomach or intestines, when ingested;

-(b) active in an unwanted manner upon the stomach or intestines to produce undesirable side effects when ingested;

(c) variable in absorption or eifect from patient to patient;

((1) slow to act when ingested so that they require massive overdoses to be effective; or

(e) of local application.

The principal types of drugs are as follows:

Type 1.-Hormones; their derivatives and analogues, such as the steroid hormones; and the polypeptide hormones e.g. vasopressin and insulin. Further examples are: oxytocin; testosterone; oestrogens, and progesterones.

Type 2.--Loca-l anaesthetics and the like e.g., ligno caine hydrochloride and diperodon hydrochloride.

Type 3.Sympathomimet-ic amines e.g., adrenaline, noradrenaline, isprenaline and amphetamine, and substances which have an opposing action such as ergotamine and dibenilene.

Type 4.--Substances to be given when a prompt response may be desirable, e.g. vasco-dilators; quick acting diuretics; analgesics e.g. morphine; and cardiovascular reactants e.g. glyceryl trinitrate.

Type 5.-Substances having an optimum dose not ascertainable before administration, e.g. oxytocin, digitalin, barbiturates, muscle relaxants and ganglion blocking agents.

Type 6.-Substances acting on the parasympathetic system, e.g. acetylcholine, anticholinesterases and physestigmine.

Type 7.Various other substances which are potent when absorbed, such as antihistamines, e.g. promethazine; alkaloids, and glycosides such as atropine and hyoscine; nitrates e.g. amyl nitrate; analeptics e.g. caffine and amphetamines; cytoatoxic agents; anticoagulants e.g. heparin; vitamins such as cyanocobalamin; and trace element substances.

Type 8.Metabolic reactants for clincal investigations e.g. para-amino-hippuric acid.

It is possible to use any drug which is sufliciently stable, potent, and absorbable. A good example is insulin even though it has a substantial molecular weight.

In use when it is desired to administer a given amount of the drug, an appropriate length of the vehicle is severed from the strip and the severed length is inserted into the buccal su'lcus as described. It is thereafter entirely absorbed into the gum or is allowed to be absorbed until the desired effect is obtained.

Due to the fact that the vehicle is, eflectively, a solution of the drug in a gelatinous material, the rate of absorption is remarkably constant, especially when compared with the absorption rates of a tablet of compressed particulate material having a similar overall concentra= tion of the dr g, but having a par iculate character.

Furthermore, the vehicle does not fragment and therefore may be easily removed when suflicient of the drug has been absorbed, and the cut length will be readily retained in the sulcus due to its semi-plastic nature. Since the severed length of the vehicle is entirely contained within the buccal sulcus little or none of the drug need be Washed away or inactivated by saliva, and since the vehicle is hardly felt when in place it does not provoke salivation. Furthermore, the vehicle is located away from the flow path of any saliva which may be secreted.

The length of the vehicle, being severed from a strip, may be chosen so as to facilitate the administration of an exact and chosen amount ofthe drug.

Due to its adhesive properties and to the fact that the severed lengths of the vehicle tends to adopt the shape of the sulcus after a very short time, the patient can talk, eat, smoke, drink and cough without any fear of ingesting or swallowing the vehicle.

In one particular application and embodiment the vehicles are impregnated with oxytocin, a drug which is used to induce labour in pregnancy. It will be readily appreciated that the vehicle and method described offer a further advantage, in this particular application, in that oxytocin is usually administered as an intravenous drip which is extremely inconvenient during the wait for labour to begin. The vehicle obviates the need for an intravenous drip, and can be removed as soon as the required degree of muscular contractions are evident. Thus the risk of rupturing the uterus may be substantially reduced. In this case should the vehicle be swallowed the drug will become inactivated by the stomach and no damage will advertently ensue. The vehicle also obviates some disadvantages which are inherent in compressed pulverulent tablets, e.g. such tablets are often uncomfortable and make their presence felt in the mouth and thus stimulate salivation, such salivation causing the substance to be washed away and sometimes inactivated. Therefore, the vehicle may contain a smaller dosage than a comparable tablet and yet be just as effective. Furthermore, the vehicle is absorbed in a more regular manner and absorption peaks, and the corresponding over reactions by the patient, are avoided.

Type 2 substances, i.e. local anaesthetics, are particularly suitable for use in dentistry, and the vehicle for such use may also include antibiotics and haemostatic substances, the vehicle being superimposed upon the gum adjacent the tooth to be treated or removed, to deaden the pain of injections and the subsequent operations.

The invention is not confined to the precise details of the foregoing example and many variations are possible.

For instance an absorbable preparation may be incorporated into vehicles and administered by the method of this invention, which is particularly suitable for the administration of drugs which vary in potency according to the condition of the patient, as the vehicle may be removed when sufficient of the drug has been absorbed.

The vehicle may be prepared by any suitable means and from any suitable flexible or gelatinous material, and, in the stance wherein the material comprises mainly glyco-gelatine, various plasticisors and diluents may be incorporated, not only to improve and/ or vary the qualities of the vehicle, but also to facilitate the production thereof, and the incorporation of the drug or drugs thereinto. Also, the vehicle may be formed, provided with a protective coating and marker linearly in a continuous operation. The vehicle may have any suitable cross-section but the cross-section should be of a size and shape commensurate with the size of the buccal sulcus of an average person. It is possible also to form smaller dimensioned vehicles suitable for treating children. Any coating provided on the vehicle may be of a type which must be removed before use, or a saliva soluble coating may be used, the vehicle being moistened with saliva before insertion into the buccal sulcus. It is also possible to embody in the vehicle a drug suitable for administration to animals.

I claim:

1. A vehicle for administering a drug comprising: an elongate sectionalized strip for resiliently flexible gelatinous material enabling a desired length thereof conveniently to be inserted into the buccal sulcus for adherence to the gum thereat and containing a drug absorbable through a users buccal mucous membrane, the said strip being formed at intervals therealong to facilitate it being subdivided for providing individual sections of a desired drug dosage, with the strip being formed at intervals therealong with depressions extending transversely of the strip and dividing the latter into a plurality of sections each being connected to the next adjacent sections by readily tearable ligaments.

2. A vehicle as claimed in claim 1 wherein the strip is of oval or circular cross-section.

3. A vehicle as claimed in claim 1 where in the strip is of a form having two opposite and respectively concave and convex faces.

4. A vehicle as claimed in claim 1 with the strip being formed at intervals along one major surface thereof with ribs dividing the strip into plurality of sections.

5. A vehicle as claimed in claim 1 with the material of the vehicle being glyco-gelatine.

References Cited UNITED STATES PATENTS 2,068,703 1/1937 Powderrnaker '128-l55 X 2,764,501 9/1956 Perri 128--l56 X 3,249,109 5/1966 Maeth et a1 128268 ADELE M. EAGER, Primary Examiner.

U.S. Cl. X.R.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2068703 *May 25, 1935Jan 26, 1937Powdermaker FrankBandage
US2764501 *Jun 18, 1953Sep 25, 1956Perri Myrtle SangreeSupply of pressure-sensitive reinforcements for paper and the like
US3249109 *Nov 1, 1963May 3, 1966Maeth HarryTopical dressing
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3598123 *Apr 1, 1969Aug 10, 1971Alza CorpBandage for administering drugs
US3696811 *Jun 17, 1971Oct 10, 1972Squibb & Sons IncPeriodontal bandage and backing therefor
US3698392 *Apr 21, 1971Oct 17, 1972Kewanee Oil CoTopical dressing
US3731683 *Jun 4, 1971May 8, 1973Alza CorpBandage for the controlled metering of topical drugs to the skin
US3797496 *May 6, 1972Mar 19, 1974Physio Medics IncPost-extraction pads
US3960150 *Sep 15, 1975Jun 1, 1976Alza CorporationBioerodible ocular device
US3972995 *Apr 14, 1975Aug 3, 1976American Home Products CorporationDosage form
US3981303 *Jul 31, 1975Sep 21, 1976Alza CorporationBioerodible ocular device
US3986510 *Aug 1, 1975Oct 19, 1976Alza CorporationBioerodible ocular device
US3991760 *Dec 2, 1975Nov 16, 1976The Procter & Gamble CompanyVaginal medicament dispensing means
US3993071 *Jul 24, 1975Nov 23, 1976Alza CorporationBioerodible ocular device
US3993073 *Mar 3, 1975Nov 23, 1976Alza CorporationNovel drug delivery device
US3995633 *Dec 2, 1975Dec 7, 1976The Procter & Gamble CompanyVaginal Medicament dispensing device
US4020558 *Jul 21, 1975May 3, 1977Societe SodermecBuccal implant for administering solubilizable products
US4039653 *Jul 21, 1975Aug 2, 1977Defoney, Brenman, Mayes & BaronBreath deodorants, sustained release
US4292299 *Jul 7, 1980Sep 29, 1981Teijin LimitedSlow-releasing medical preparation to be administered by adhering to a wet mucous surface
US4451260 *Mar 26, 1982May 29, 1984Minnesota Mining And Manufacturing CompanySustained release oral medicinal delivery device
US4470962 *Apr 28, 1981Sep 11, 1984Key Pharmaceuticals, Inc.Polyvinyl alcohol, polyvinylpyrrolidone, transdermal drugs
US4482533 *Mar 28, 1983Nov 13, 1984Key Pharmaceuticals, Inc.Polymeric diffusion matrix containing propranolol
US4529589 *Sep 29, 1983Jul 16, 1985Davydov Anatoly BWith 5-((N-(3-methoxypyridazinyl)-6-sulphamido)-phenylazo)salicylic acid
US4568536 *Feb 8, 1985Feb 4, 1986Ethicon, Inc.Mixture of calcium stearate, dextran and natural or synthetic oil or wax
US4647448 *Dec 21, 1984Mar 3, 1987Smith Kline & French Laboratories LimitedPharmaceutical dosage unit
US4713239 *Nov 19, 1985Dec 15, 1987Vsesojuny Kardiologichesky Nauchny Tsentr Adkaemii Meditsinski Nauk SssrAbsorption through the mucous membranes of the mouth
US4764378 *Feb 10, 1986Aug 16, 1988Zetachron, Inc.Matrices of high and low molecular weight polyoxyethylene glycols
US4842854 *May 13, 1987Jun 27, 1989Vsesojuzny Kardiologichesky Nauchny Tsentr Akademii Meditsinskiki Nauk SsrSustained release delivery of drug directly to blood
US4849246 *Oct 7, 1986Jul 18, 1989Wolfgang SchmidtProcess for producing an administration or dosage form for drugs, reagents or other active ingredients
US4921695 *Mar 9, 1989May 1, 1990Babaian Eduard AAntianginal plate for treating ischemic heart disease
US5484602 *Jan 20, 1995Jan 16, 1996University Of Utah Research FoundationDrug contained in lollipop
US6264974Jul 7, 1998Jul 24, 2001Salvagnini Italia SpaBuccal and sublingual administration of physostigmine
US6596298Sep 14, 1999Jul 22, 2003Warner-Lambert CompanyPullulan and antimicrobially effective amounts of thymol, methyl salicylate, eucalyptol and menthol
US6659442Jan 29, 1999Dec 9, 2003Lts Lohamann Therapie-Systeme AgMethod and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile
US6682756Nov 21, 1997Jan 27, 2004Lts Lohmann Therapie-Systeme AgFlexible; break and tear resistant; storage stable
US6800329 *Dec 9, 2002Oct 5, 2004Lts Lohmann Therapie-Systeme AgMethod for producing film-type dosage
US6923981Apr 17, 2003Aug 2, 2005Warner-Lambert CompanyFast dissolving orally consumable films
US7025983Apr 18, 2001Apr 11, 2006Warner-Lambert Company LlcWater soluble film forming polymer
US7067116Mar 23, 2000Jun 27, 2006Warner-Lambert Company LlcMixture of water soluble film forming polymer such as pullulan , dextromethorphan and an ion exchange resin such as Amberlite
US7175172 *Sep 9, 2003Feb 13, 2007Lts Lohmann Therapie-Systeme AgMethod and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile
US7232500Jan 15, 2003Jun 19, 2007Lts Lohmann Therapie-Systeme AgMethod and device for producing products in web form
US7357891Jan 30, 2004Apr 15, 2008Monosol Rx, LlcProcess for making an ingestible film
US7407669Oct 14, 2003Aug 5, 2008Mcneil-Ppc, delivers at least one oral care agent, such as antimicrobial agents and salivary stimulants
US7425292Feb 14, 2002Sep 16, 2008Monosol Rx, LlcThin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7491406Oct 13, 2005Feb 17, 2009Mcneil-Ppc, Inc.Fast dissolving orally consumable films
US7648712May 5, 2006Jan 19, 2010Mcneil-Ppc, Inc.Fast dissolving orally consumable films containing a taste masking agent
US7666337May 28, 2004Feb 23, 2010Monosol Rx, LlcPolyethylene oxide-based films and drug delivery systems made therefrom
US7824588Apr 14, 2008Nov 2, 2010Monosol Rx, LlcWater degradation; controlled drying; digestible film containing water soluble polymer
US7910641Dec 14, 2006Mar 22, 2011Monosol Rx, LlcPH modulated films for delivery of actives
US7972618Sep 20, 2007Jul 5, 2011Monosol Rx, LlcEdible water-soluble film containing a foam reducing flavoring agent
US8017150Apr 22, 2008Sep 13, 2011Monosol Rx, LlcPolyether combined with hydrophilic cellulosic material; demonstrates non-self-aggregating, uniform heterogeneity; mucosally adhesive water soluble product containing analgesic opiate; preventing air pocket formation during production
US8357114Jan 5, 2007Jan 22, 2013Acelrx Pharmaceuticals, Inc.Drug dispensing device with flexible push rod
US8475832Aug 7, 2009Jul 2, 2013Rb Pharmaceuticals LimitedSublingual and buccal film compositions
US8499966Dec 28, 2007Aug 6, 2013Acelrx Pharmaceuticals, Inc.Method of moving a delivery member of a dispensing device for administration of oral transmucosal dosage forms
US8535714Oct 18, 2011Sep 17, 2013Acelrx Pharmaceuticals, Inc.Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8548623Mar 16, 2010Oct 1, 2013Acelrx Pharmaceuticals, Inc.Storage and dispensing devices for administration of oral transmucosal dosage forms
US8574189Mar 9, 2012Nov 5, 2013Acelrx Pharmaceuticals, Inc.Storage and dispensing devices for administration of oral transmucosal dosage forms
US8603514Jul 10, 2007Dec 10, 2013Monosol Rx, LlcUniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8652378Mar 29, 2013Feb 18, 2014Monosol Rx LlcUniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8663687May 13, 2010Mar 4, 2014Monosol Rx, LlcFilm compositions for delivery of actives
US8685437Mar 26, 2009Apr 1, 2014Monosol Rx, LlcThin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US8753308Nov 15, 2012Jun 17, 2014Acelrx Pharmaceuticals, Inc.Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8758803Apr 30, 2009Jun 24, 2014Lts Lohmann Therapie-Systeme AgFilm-shaped preparation comprising oily substances for oral administration
US8765167Sep 8, 2006Jul 1, 2014Monosol Rx, LlcUniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8778393Jul 23, 2012Jul 15, 2014Acelrx Pharmaceuticals, Inc.Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8778394Jul 30, 2012Jul 15, 2014Acelrx Pharmaceuticals, Inc.Small-volume oral transmucosal dosage forms
US8865211Aug 27, 2012Oct 21, 2014Acelrx Pharmaceuticals, Inc.Bioadhesive drug formulations for oral transmucosal delivery
US8865743Nov 14, 2007Oct 21, 2014Acelrx Pharmaceuticals, Inc.Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8883191Dec 26, 2003Nov 11, 2014Lts Lohmann Therapie-Systeme AgMethod for producing individually dosed active substance-containing and, in particular, aromatics-containing film-shaped administration forms rapidly disintegrating upon contact with liquid
US8900497Aug 23, 2013Dec 2, 2014Monosol Rx, LlcProcess for making a film having a substantially uniform distribution of components
US8900498Aug 23, 2013Dec 2, 2014Monosol Rx, LlcProcess for manufacturing a resulting multi-layer pharmaceutical film
US8905964Jan 18, 2013Dec 9, 2014Acelrx Pharmaceuticals, Inc.Drug storage and dispensing devices and systems comprising the same
US8906277Aug 23, 2013Dec 9, 2014Monosol Rx, LlcProcess for manufacturing a resulting pharmaceutical film
US8945592Nov 21, 2008Feb 3, 2015Acelrx Pharmaceuticals, Inc.Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
USRE37382Dec 10, 1998Sep 18, 2001Alayne YatesFor diffusing medication (diphenylhydantoin sodium) slowly through a semi-permeable membrane and into the saliva which stimulates nerve, bone, and tissue growth
USRE42126Jun 30, 2000Feb 8, 2011The Procter & Gamble Companysystem for delivering oral care substance to oral cavity comprising a removable backing strip having sufficient flexibility to be conformable to oral surface and oral care composition that forms film when applied to backing strip comprising organosiloxane resin, rheology modifier, and oral care substance
DE2656387A1 *Dec 13, 1976Jun 30, 1977Hoffmann La RocheFeste pharmazeutische einheitsdosierungsform als darreichunsform eines medikaments sowie verfahren und anlage zu ihrer herstellung
DE4217102A1 *May 22, 1992Nov 25, 1993Winand NeuhausenU-shaped mouth insert fitting between upper and lower teeth - releasing gas vapour or odour to mask or neutralise mouth odour
DE102008023345A1May 13, 2008Nov 19, 2009Lts Lohmann Therapie-Systeme AgFilmförmige Zubereitung mit öligen Substanzen zur oralen Verabreichung
EP0157909A1 *Mar 10, 1982Oct 16, 1985MERCK PATENT GmbHCorpuscules containing medicaments
WO1982003174A1 *Mar 10, 1982Sep 30, 1982Merck Patent GmbhCorpuscles containing drugs and use thereof in medecine and surgery
WO2002102296A1 *Jun 13, 2002Dec 27, 2002Grummel AndreasDosing stick containing rod-shaped tablets
U.S. Classification604/77, 206/438, 206/820
International ClassificationA61J7/00, A61J3/10, A61M35/00
Cooperative ClassificationA61M35/00, A61J7/0092, A61J3/10, Y10S206/82
European ClassificationA61J3/10, A61J7/00G, A61M35/00