|Publication number||US3456646 A|
|Publication date||Jul 22, 1969|
|Filing date||Jan 19, 1967|
|Priority date||Jan 19, 1967|
|Publication number||US 3456646 A, US 3456646A, US-A-3456646, US3456646 A, US3456646A|
|Inventors||Phillips Robert E, Thiel Charles G|
|Original Assignee||Dart Ind Inc|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (3), Referenced by (95), Classifications (6)|
|External Links: USPTO, USPTO Assignment, Espacenet|
y 1969 R. E. PHILLIPS ETAL 3,456,646
INHALATION'ACTUATED AEROSOL DISPENSING DEVICE Filed Jan. 19, 1967 2 Sheets-Sheet l INVENTORS N ww fw L/ d 5mm H a P s 25 Esa rum Ti 3 RC 6 m w July 22, 1969 R. E. PHILLIPS ET AL INHALATION-ACTUATED AEROSOL DISPENSING DEVICE Filed Jan. 19, 1967 2 SheetsSheet 2 ma mg V/ //l //l I//// wm E hm Ww V/// I [A Il/I P WNW? w m7? N H .A P fi EN 5 5w TEW R H R c sm w P K $7 W w QQ Q Q Q Q Q A United States Patent US. Cl. 128-173 7 Claims ABSTRACT OF THE DISCLOSURE An aerosol dispensing device for discharging a metered amount of a medicament-containing aerosol into the mouth of a patient during inhalation. The device is initially manually compressed to a charging condition and is automatically discharged by a mechanism actuated by the breathing of the patient.
This invention relates to a dispensing device which is particularly suited for dispensing and administering measured amounts of fluids. The principal use for devices of this type at the present time is in dispensing metered amounts of a medicament-containing aerosol for inhalation therapy.
A variety of devices for administering medicament during inhalation have been developed and used. It is an object of the present invention to provide a new and improved device which utilizes the manual compressive force of the patient for maintaining the device in a charging or ready condition and a trigger actuated mechanism for discharging. A further object is to provide such a device wherein the trigger mechanism is breath actuated, permitting the manually applied force to discharge the dose. An additional object is to provide such a dispensing device which is inexpensive, simple and dependable.
A variety of materials, particularly in the medical field, are being packaged and sold in aerosol containers, usually with a built-in metering valve. It is a particular object of the present invention to provide a new and improved dispensing device for use with commercially available aerosol containers. A further object is to provide such a device in which the user can readily remove and replace the containers. A particular object is to provide such a device wherein the metering valve action is provided by the manually applied forces of the patient upon the container.
It is an object of the invention to provide a dispensing device for use in combination with an aerosol dispensing container equipped with a metering valve movable between charging and discharging positions and having a discharge tube at one end thereof and charged with a selfpropelling liquid composition, the device including a housing for receiving the container for reciprocation of the container within the housing, with the housing including means defining an air passage therethrough and including a support member having an opening receiving the discharge tube and providing a discharge passage for the tube into the air passage. A further object is to provide such a device including a vane or trigger member disposed in the air passage and movable between a first position substantially blocking the passage and a second position not blocking the passage, bias means urging the vane member toward the first position, and latch means carried in the housing engaging the container and vane member, with the vane member when in the first position maintaining the container and valve means in the charging position when a compression force is applied to the container urging the valve means to the discharging position, and with a pressure differential in the air passage across the vane member moving the vane member to the second position, permitting 3,456,546 Patented July 22, 1969 movement of the valve means to the discharging position under continued application of the compression force.
It is a particular object of the invention to provide such a dispensing device in which the pressure differential is produced by the inhalation of the patient. Another object is to provide such a device in which the compression force is manually applied and maintained by the patient.
The invention also comprises novel details of construction and novel combinations and arrangements of parts, which will more fully appear in the course of the following description. The drawings merely show and the description merely describes preferred embodiments of the present invention which are given by way of illustration or example.
In the drawings:
FIG. 1 is a side view of the preferred embodiment of the dispensing device of the invention;
FIG. 2 is an enlarged partial sectional view showing the device of FIG. 1 in the charging position;
FIG. 3 is a view similar to that of FIG. 2 showing the device in the discharging position; and
FIGS. 4 and 5 are views corresponding to FIGS. 2 and 3, respectively, showing an alternative embodiment of the device.
Referring to the device of FIGS. 1-3, a container is slidably positioned within a cylindrical portion 11 of a housing 12. An air passage is provided through the housing between a plurality of inlet openings 13 and a mouthpiece 14.
The container 10 may be a conventional aerosol dispensing container such as is described in United States Patent No. 3,001,524. A metering valve may be incorporated in the container 10 and includes a stem 21 movable between a charging position (FIG. 2) and a discharging position (FIG. 3). A tank 22 is fixed in the end of the container 10 with a gasket 23 at the container opening. Another gasket 24 and a plate 25 are positioned at the other end of the tank 22. A spring 26 is positioned about the stem 21 and is compressed between the plate 25 and a shoulder 27 on the stem. The stem has a tubular outer end 28 with a lateral passage 29.
When the valve is in the charging position of FIG. 2, fluid from the container 10 flows in the tank 22 around the reduced inner end of the stem 21. Engagement of the shoulder 27 with the gasket 23 prevents discharge from the container. For discharging, the spring 26 is compressed to the position of FIG. 3, bringing the shoulder 30 of the pin 21 into sealing engagement with the gasket 24 and at the same time, bringing the lateral opening 29 into the interior of the tank 22. The measured charge of material within the shell is discharged through the tubular end 28 of the stem of the valve.
When the container 10 is inserted in the housing 12, the end 28 of the valve stem is positioned in a support member of the housing and a passage 36 provides for fiow from the valve into the air passage of the housing. The container is preferably but not necessarily removable and replaceable.
A trigger element in the form of a flapper or vane 33 is pivotally carried in the housing between a base portion 39 and an upwardly extending arm member 40. A spring member 41, typically a leaf spring of a resilient material such as beryllium copper, is fastened to the housing by a pin 42, passes over a spacer 43 and through a notch in the member 40, to engage the vane 38, urging it in the clockwise direction as viewed in RIG. 2.
A bar 45 slides in an opening 46 in the housing and is pivotally connected to a second bar 47. The second bar 47 is also pivotally carried on the vane 38.
The member 40 and a similar projecting member 50 coact to define an opening 51 in the air passage through the housing. This opening is substantially closed by the vane 38 when in the position of FIG. 2. A plurality of passages 53 may be provided in the vane 38, the passages normally being closed by a resilient cover 54 carried on the vane 38.
A cycle of operation of the device starts with the condition of FIG. 2. The valve 20 is in the charging position and the shell 22 is filled with fluid from the container 10. A compression force is applied to the housing and container, as by placing the thumb at the bottom of the housing and one or two fingers at the top of the container, as viewed in FIG. 1. A downward force is exerted on the bar 45 and the bar 47 and the vane 38. The arrangement of these parts is such that the bars 45, 47 function as a latch or toggle and maintain the mechanism in the position of FIG. 2. The patient then places the mouthpiece 14 in his mouth and starts to inhale. This act of inhalation produces a pressure differential across the vane 38, resulting in a force which moves the vane counterclockwise against the urging of the spring 41 thus triggering the latch or breaking the toggle. The vane moves to the position of FIG. 3 under the continued application of the manual force exerted through the container and the bars 45, 47. This permits movement of the container 10 relative to the housing 12 to the valve discharging position of FIG. 3. A measured amount of the fluid from the container is injected into the air passage as the patient is inhaling, providing the desired dosage.
After inhalation, the manual compression force is released, permitting ret-urn of the device to the position of FIG. 2. The device is now ready for administration of another dose. The openings 53 in the vane 38 permit exhalation by the patient with the mouthpiece 14 in the patients mouth. The cover 54 serves to block the passages 53 during inhalation to obtain maximum pressure differential. When the vane moves to the position of PEG. 3, ready flow of air is permitted over the top of the vane and also around the lower portion, since that portion of the vane below the top of the projecting member 40 need not extend the entire width of the opening 51.
An alternative form of the device is shown in FIGS. 4 and 5. A container 10 is positioned in a housing 60 having the same general configuration as the housing 11. The tubular end 28 of the valve 20 rests in the support member 35, with a passage 36 providing communication to the air passage through the housing. In this embodiment, the housing air passage starts at the top of the housing, passing around the container 10' and through an opening 61 to the mouthpiece 14. A vane member 62 normally closes the passage 61 and is urged to the closed position by a spring 63 fixed to the housing with a pin 64. A bar 65 is pivotally mounted in an opening in the housing, with one end of the bar engaging the container 10 and the other end of the bar pivotally receiving a second bar 66. The other end of the bar 66 is pivotally mounted in the vane member 62.
The operation of the device of FIGS. 4 and is similar to that of the device of FIGS. 1-3. The mechanism is initially in the position of FIG. 4 and the valve is charged. The patient applies the manual compression force, but the bars 65, 66 remain in the latched position. The patient places the mouthpiece 14 in his mouth and starts to inhale, thereby producing a pressure differential across the vane member 62 causing it to pivot clockwise to the position of FIG. 5. This triggers the latch mechanism, permitting clockwise rotation of the bar 65 and downward movement of the container to the position of FIG. 5, with a resultant discharge of the measured dose into the air passage. When the manual pressure is released, the mechanism returns to the position of FIG. 4.
Although exemplary embodiments of the invention have been disclosed and discussed, it will be understood that other applications of the invention are possible and that the embodiments disclosed may be subjected to various changes, modifications and substitutions without necessarily departing from the spirit of the invention.
We claim as our invention:
1. In a dispensing device for use in combination with an aerosol dispensing container equipped with a metering valve means movable between charging and discharging positions and having a discharge tube at one end thereof and charged with a self-propelling liquid composition, the improvement comprising:
a housing for receiving said container for reciprocation of said container within said housing, said housing including means defining an air passage therethrough,
said housing including a support member having an opening receiving said discharge tube and providing a discharge passage for said tube into said air passage;
a vane member disposed in said air passage and movable between a first position substantially blocking said passage and a second position not blocking said passage;
bias means urging said vane member toward said first position; and
latch means carried in said housing and engaging said container and said vane member, with said vane member when in said first position maintaining said container and valve means in said charging position when a compression force is applied to said container urging said valve means to the discharging position, and
with a pressure differential in said air passage across said vane member moving said vane member to said second position, permitting movement of said valve means to the discharging position under continued application of said compression force.
2. A device as defined in claim 1 in which said latch means includes a toggle joint positioned between said container and said vane member.
3. A device as defined in claim 1 in which said latch means comprises first and second bars joined at a pivot point with the other end of said first bar engaging said container in force transmitting relation and with the other end of said second bar pivotally engaging said vane memher.
4. A device as defined in claim 1 in which said vane member is pivotally mounted in said housing for movement between said first and second positions,
and in which said latch means comprises first and second bars joined at a pivot point, with said first bar slidably positioned in an opening in said housing and with the other end thereof engaging said container for reciprocation in said housing with said container, and with the other end of said second bar pivotally engaging said vane member.
5. A device as defined in claim 1 in which said vane member is pivotally mounted in said housing for movement between said first and second positions,
and in which said latch means comprises first and second bars joined at a pivot point, with said first bar pivotally mounted in an opening in said housing and with the other end thereof engaging said container, and with the other end of said second bar pivotally engaging said vane member.
6. In a dispensing device, the combination of:
a housing including an aerosol dispensing container charged with a self-propelling liquid composition, said housing including means defining an air passage therethrough;
metering valve means coupled to said container and movable between a charging position for receiving a charge from said container and a discharging position for dispensing said charge;
trigger means disposed in said air passage and movable between a first position substantially blocking said passage and a second position not blocking said passage;
bias means urging said trigger means toward said first position; and
latch means carried in said housing and engaging said container and said trigger means, with said trigger means when in said first position maintaining said container and valve means in said charging position when a compression force is applied to said container urging said valve means to the discharging position, and
with a pressure differential in said air passage across said trigger means moving said trigger means to said second position, permitting movement of said valve means to the discharging position under continued application of said compression force.
7. A device as defined in claim 6 in which said latch means includes a toggle joint comprising first and second References Cited UNITED STATES PATENTS 2,992,645 7/1961 Fowler 128-266 XR 3,001,524 9/1961 Maison et al 128-208 XR 3,187,748 6/1965 Mitchell et al 128173 RICHARD A. GAUDET, Primary Examiner MARTIN F. MAJESTIC, Assistant Examiner US. Cl. X.R. 128--208, 211
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2992645 *||Mar 26, 1959||Jul 18, 1961||Benger Lab Ltd||Disperser for powders|
|US3001524 *||Mar 5, 1957||Sep 26, 1961||Riker Laboratories Inc||Aerosol dispensing apparatus|
|US3187748 *||Apr 29, 1963||Jun 8, 1965||Merck And Company Inc||Inhalation-actuated aerosol device|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3565070 *||Feb 28, 1969||Feb 23, 1971||Riker Laboratories Inc||Inhalation actuable aerosol dispenser|
|US3636949 *||Aug 8, 1969||Jan 25, 1972||Armstrong Kropp Dev Corp||Inhalation-initiated aerosol dispenser|
|US3732864 *||Jun 7, 1971||May 15, 1973||Schering Corp||Inhalation coordinated aerosol dispensing device|
|US3789843 *||Feb 23, 1972||Feb 5, 1974||Armstrong Kropp Dev Corp||Breath-actuated aerosol dispenser|
|US3826413 *||Jul 18, 1972||Jul 30, 1974||Bespak Industries Ltd||Device for dispensing fluids|
|US4291688 *||Dec 17, 1979||Sep 29, 1981||Schering Corp.||Inhalation device|
|US4576157 *||Oct 24, 1983||Mar 18, 1986||Raghuprasad Puthalath K||Oral inhalation apparatus|
|US4592348 *||Dec 17, 1984||Jun 3, 1986||Waters Iv William C||Aerosol inhaler|
|US4664107 *||Oct 25, 1984||May 12, 1987||Minnesota Mining And Manufacturing Company||Inhalation activatable dispensers|
|US4803978 *||Aug 21, 1987||Feb 14, 1989||Johnson Iv John J||Apparatus for actuating an inhaler|
|US4819834 *||Sep 9, 1986||Apr 11, 1989||Minnesota Mining And Manufacturing Company||Apparatus and methods for delivering a predetermined amount of a pressurized fluid|
|US4896832 *||Aug 25, 1988||Jan 30, 1990||Bespak Plc||Dispensing apparatus for metered quantities of pressurised fluid|
|US5027808 *||Oct 31, 1990||Jul 2, 1991||Tenax Corporation||Breath-activated inhalation device|
|US5031610 *||May 3, 1988||Jul 16, 1991||Glaxo Inc.||Inhalation device|
|US5040527 *||Dec 18, 1990||Aug 20, 1991||Healthscan Products Inc.||Metered dose inhalation unit with slide means|
|US5060643 *||Aug 7, 1990||Oct 29, 1991||Tenax Corporation||Breath-activated inhalation device|
|US5062423 *||Feb 27, 1990||Nov 5, 1991||Minnesota Mining And Manufacturing Company||Equine aerosol drug delivery method and apparatus|
|US5069204 *||Aug 17, 1990||Dec 3, 1991||Riker Laboratories, Inc.||Inhaler|
|US5119806 *||Dec 14, 1989||Jun 9, 1992||Glaxo Inc.||Inhalation device|
|US5201322 *||Mar 28, 1990||Apr 13, 1993||Elf Atochem North America, Inc.||Device for detecting air flow through a passageway|
|US5224472 *||Feb 8, 1991||Jul 6, 1993||Solange Quenderff||Inhalation device|
|US5231983 *||Oct 7, 1991||Aug 3, 1993||Minnesota Mining And Manufacturing||Method of and apparatus for the aerosol administration of medication|
|US5347998 *||Jul 8, 1991||Sep 20, 1994||Minnesota Mining And Manufacturing Company||Breath actuated inhaler having an electromechanical priming mechanism|
|US5392768 *||Jan 29, 1993||Feb 28, 1995||Aradigm||Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval|
|US5394866 *||Jan 29, 1993||Mar 7, 1995||Aradigm Corporation||Automatic aerosol medication delivery system and methods|
|US5404871 *||Mar 5, 1991||Apr 11, 1995||Aradigm||Delivery of aerosol medications for inspiration|
|US5450336 *||Jan 29, 1993||Sep 12, 1995||Aradigm Corporation||Method for correcting the drift offset of a transducer|
|US5497764 *||Mar 9, 1995||Mar 12, 1996||Aradigm Corporation||Medication cassette for an automatic aerosol medication delivery|
|US5511540 *||Aug 18, 1993||Apr 30, 1996||Minnesota Mining And Manufacturing Company||Inhalation device|
|US5520166 *||Apr 28, 1995||May 28, 1996||Aradigm Corporation||Medication cassette for an automatic aerosol medication delivery system|
|US5522385 *||Sep 27, 1994||Jun 4, 1996||Aradigm Corporation||Dynamic particle size control for aerosolized drug delivery|
|US5542410 *||Dec 9, 1994||Aug 6, 1996||Aradigm Corporation||Delivery of aeerosol medications for inspiration|
|US5608647 *||Sep 8, 1995||Mar 4, 1997||Aradigm Corporation||Method for releasing controlled amount of aerosol medication|
|US5622162 *||Feb 16, 1995||Apr 22, 1997||Aradigm Corporation||Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval|
|US5743252 *||Nov 27, 1996||Apr 28, 1998||Aradigm Corporation||Method for releasing controlled amount of aerosol medication|
|US5755218 *||Nov 27, 1996||May 26, 1998||Aradigm Corporation||Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval|
|US5813614 *||Mar 28, 1995||Sep 29, 1998||Electrosols, Ltd.||Dispensing device|
|US5826570 *||Apr 23, 1997||Oct 27, 1998||Aradigm Corporation||Delivery of aerosol medications for inspiration|
|US5915377 *||May 25, 1995||Jun 29, 1999||Electrosols, Ltd.||Dispensing device producing multiple comminutions of opposing polarities|
|US5957124 *||Sep 27, 1995||Sep 28, 1999||Aradigm Corporation||Dynamic particle size control for aerosolized drug delivery|
|US6012454 *||Jun 10, 1997||Jan 11, 2000||Minnesota Mining And Manufacturing Company||Dry powder inhalation device|
|US6068199 *||Apr 10, 1997||May 30, 2000||Electrosols, Ltd.||Dispensing device|
|US6105571 *||Jun 2, 1995||Aug 22, 2000||Electrosols, Ltd.||Dispensing device|
|US6119688 *||Jun 1, 1995||Sep 19, 2000||3M Innovative Properties Company||Powder dispenser|
|US6252129||Jul 22, 1997||Jun 26, 2001||Electrosols, Ltd.||Dispensing device and method for forming material|
|US6318640||Mar 24, 2000||Nov 20, 2001||Electrosols, Ltd.||Dispensing device|
|US6386195||Aug 19, 1999||May 14, 2002||Electrosols Ltd.||Dispensing device|
|US6439227 *||Oct 12, 2000||Aug 27, 2002||Microdrug Ag||Breath-actuation|
|US6457470||Nov 20, 2000||Oct 1, 2002||Electrosols Ltd.||Dispensing device|
|US6460537||Nov 9, 1999||Oct 8, 2002||3M Innovative Properties Company||Breath-actuated aerosol dispensers|
|US6581590 *||Mar 21, 2000||Jun 24, 2003||Iep Pharmaceutical Devices Inc.||Inhalation actuated device|
|US6595208||Aug 7, 1998||Jul 22, 2003||Battelle Memorial Institute||Dispensing device|
|US6745761||Jun 19, 2003||Jun 8, 2004||Astrazeneca Ab||Inhaler|
|US6779520 *||Oct 30, 2001||Aug 24, 2004||Iep Pharmaceutical Devices Inc.||Breath actuated dry powder inhaler|
|US6823863 *||Mar 16, 2001||Nov 30, 2004||Astrazeneca Ab||Inhaler|
|US6866038 *||Jan 24, 2002||Mar 15, 2005||Clinical Designs Limited||Firing flap dispenser|
|US6880554||Aug 21, 2000||Apr 19, 2005||Battelle Memorial Institute||Dispensing device|
|US6889687||Nov 2, 2000||May 10, 2005||Shl Medical Ab||Inhalator with aerosolizing unit|
|US7193124||Jan 11, 2001||Mar 20, 2007||Battelle Memorial Institute||Method for forming material|
|US7464708||May 19, 2003||Dec 16, 2008||3M Innovative Properties Company||Dose indicators and dispensing canister-indicator assemblies|
|US7721731||Feb 20, 2004||May 25, 2010||Clinical Designs Ltd.||Dispenser|
|US7814900||Mar 17, 2003||Oct 19, 2010||Clinical Designs Limited||Can fixture|
|US8308028||Nov 19, 2004||Nov 13, 2012||Clinical Designs Limited||Dispenser and reservoir|
|US8357696||Jan 28, 2010||Jan 22, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8408208||Dec 10, 2004||Apr 2, 2013||Clinical Designs Limited||Dispenser and counter|
|US8524734||Oct 22, 2009||Sep 3, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8524735||Oct 22, 2009||Sep 3, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8546423||Oct 22, 2009||Oct 1, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8629139||Oct 6, 2009||Jan 14, 2014||Mpex Pharmaceuticals, Inc.||Topical use of Levofloxacin for reducing lung inflammation|
|US8815838||Oct 6, 2009||Aug 26, 2014||David C. Griffith||Aerosol fluoroquinolone formulations for improved pharmacokinetics|
|US9326936||Jul 17, 2014||May 3, 2016||Raptor Pharmaceuticals, Inc.||Aerosol fluoroquinolone formulations for improved pharmacokinetics|
|US9592355 *||Sep 8, 2006||Mar 14, 2017||Raymond John Bacon||Dispenser|
|US9700564||Mar 5, 2012||Jul 11, 2017||Horizon Orphan Llc||Use of aerosolized levofloxacin for treating cystic fibrosis|
|US20030079743 *||Oct 30, 2001||May 1, 2003||Genova Perry A.||Breath actuated dry powder inhaler|
|US20030103906 *||Dec 16, 2002||Jun 5, 2003||Smithkline Beecham Corporation||Metered dose inhaler having internal surfaces coated with fluorocarbon polymer|
|US20040020486 *||Mar 16, 2001||Feb 5, 2004||Huxham Laurence Stanmore||Inhaler|
|US20040065320 *||Jan 24, 2002||Apr 8, 2004||Bacon Raymond John||Dispenser|
|US20040187865 *||Apr 14, 2004||Sep 30, 2004||Smithkline Beecham Corp.||Metered dose inhaler for fluticasone propionate|
|US20050158394 *||Jan 6, 2005||Jul 21, 2005||Vectura Limited||Delivery of oral drugs|
|US20050209558 *||May 19, 2003||Sep 22, 2005||Eduard Marx||Dose indicators and dispensing canister-indicator assemblies|
|US20050235986 *||Apr 18, 2005||Oct 27, 2005||Battelle Memorial Institute||Dispensing device|
|US20060231093 *||Nov 4, 2003||Oct 19, 2006||Simon Burge||Pressurised inhalers|
|US20070062522 *||Feb 20, 2004||Mar 22, 2007||Bacon Raymond J||Dispenser|
|US20070163576 *||Mar 17, 2003||Jul 19, 2007||Bacon Raymond J||Can fixture|
|US20070235469 *||Nov 19, 2004||Oct 11, 2007||Bacon Raymond J||Dispenser and Reservoir|
|US20070251950 *||Dec 10, 2004||Nov 1, 2007||Clinical Designs Limited||Dispenser and Counter|
|US20100012115 *||Sep 8, 2006||Jan 21, 2010||Raymond John Bacon||Dispenser|
|EP0045419A1 *||Jul 17, 1981||Feb 10, 1982||FISONS plc||Inhalation device for administering medicaments|
|EP1267719A2 *||Apr 5, 2001||Jan 2, 2003||PDS Healthcare Products, Inc.||Device and method for measuring lung performance|
|EP1267719A4 *||Apr 5, 2001||Aug 1, 2007||Ferraris Group Inc||Device and method for measuring lung performance|
|EP1941868A2||Feb 26, 2001||Jul 9, 2008||PharmaKodex Limited||Improvements in or relating to the delivery of oral drugs|
|EP2594272A2||May 18, 2006||May 22, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|WO1994011044A2||Nov 8, 1993||May 26, 1994||Minnesota Mining And Manufacturing Company||Powder inhaler|
|WO2001032247A1 *||Nov 2, 2000||May 10, 2001||Shl Medical Ab||Inhalator with aerosolizing unit|
|WO2004041339A3 *||Nov 4, 2003||Jul 29, 2004||Cambridge Consultants||Pressurised inhalers|
|Cooperative Classification||A61M2015/0095, A61M15/009, A61M15/0091|