US3477431A - Combined mixing syringe and container - Google Patents

Combined mixing syringe and container Download PDF

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US3477431A
US3477431A US613774A US3477431DA US3477431A US 3477431 A US3477431 A US 3477431A US 613774 A US613774 A US 613774A US 3477431D A US3477431D A US 3477431DA US 3477431 A US3477431 A US 3477431A
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syringe barrel
plunger
syringe
container
ingredients
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US613774A
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Leonard Edward Walecka
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Abbott Laboratories
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Abbott Laboratories
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00593—Hand tools of the syringe type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00503—Details of the outlet element
    • B05C17/00516—Shape or geometry of the outlet orifice or the outlet element

Definitions

  • one of the pistons When two pistons are used, one of the pistons is positioned immediately adjacent to the enlarged portion of the syringe barrel and the other seals off the open end of the barrel, thus forming two compartments, each of which may contain a different ingredient.
  • Lock means are also provided in order to prevent accidental displacement of the plunger during transport and storage.
  • FIGURE 1 is a side elevational view in cross-section of a two-compartment syringe and container showing the two ingredients as separated.
  • FIGURE 2 is a partial side elevational view in crosssection showing the syringe plunger in position to permit mixing of the ingredients.
  • FIGURE 3 is a side elevational view, partially broken away in cross-section showing a hypodermic needle attached to the syringe and the plunger depressed for injection.
  • FIGURE 4 is a partial cross-sectional view taken along the line 44 of FIGURE 1 and showing a locking and tamperproof seal.
  • FIGURE 5 is a cross-sectional view taken along the line 5-5 of FIGURE 4.
  • FIGURE 6 is a partial cross-sectional view showing another embodiment.
  • FIGURE 7 is a partial cross-sectional. view taken along the line 7-7 of FIGURE 6 and showing another embodiment of the locking feature.
  • FIGURE 1 there is shown a two-compartment syringe and container 10 having an enlarged center portion 11 extending around the periphery of the syringe barrel 12.
  • the enlarged portion 11 is of greater diameter than the syringe barrel 12 proper and may be of any desired cross-section.
  • the package includes a plunger 13 having two spaced pistons 14,15 on the shaft 16 thereof and a threaded, tubular boss 17 on the distal or delivery end 18 of the syringe barrel 12.
  • the boss 17 includes a passage 19 which connects the interior of the syringe barrel 12 with the outer portion of the boss 17.
  • the tubular boss 17 and passage 19 therein are sealed by a cap 20.
  • the cap 20 is removed and a needle 21 is threaded onto the boss 17.
  • a cannula suitable for puncturing a stopper may be employed in place of the needle 21.
  • the plunger 13 During transport and storage, the plunger 13 must be immobilized in order to prevent accidental displacement of the distal plunger piston 15 into the enlarged portion 11 of the syringe barrel 12 since such displacement would permit undesired mixing of the ingredients.
  • One means for immobilizing the plunger is to employ a. lock washer seal.
  • the syringe barrel 12 has an open end 22 on the proximal end thereof.
  • the tamperproof seal and locking device 23 illustrated in detail in FIG- URES 4 and 5 may be employed.
  • a hinged lock washer 24 is fastened to the syringe barrel 12 by means of a bracket 25 and pivot pin 26.
  • the lock Washer 24 fits into a slot 27 in the plunger shaft 16, thereby preventing longitudinal movement of the plunger 13.
  • an extended portion 28 may be provided, which portion engages a slotted bracket 29 fastened to the syringe barrel 12.
  • the lock washer 24 is released (shown in phantom lines in FIGURE 4) to permit movement of the plunger 13 and associated pistons 14, 15.
  • FIGURES 6 and 7 Another embodiment of the device of this invention which employs a single piston and a different locking device is illustrated in FIGURES 6 and 7.
  • the open end 22 of the syringe barrel 12 is closed by a cover 30 through which the shaft 16 of the plunger 13 extends.
  • the plunger shaft 16 is of cruciform cr0ss-section and has a slot therein (not shown) immediately adjacent to the cover 30 when the plunger 13 is in the extended position as shown in FIGURE 1.
  • a lock washer 31 which abuts against the cover 30, thereby preventing movement of the plunger 13.
  • the locking device is removed to permit movement of the plunger 13.
  • a single piston 32 can be utilized to divide the syringe barrel 12 into two compartments.
  • the piston 32 can be disposed on either side of the enlarged portion 11 of the syringe barrel 12. As shown in FIGURE 6, the piston 32 is disposed toward the delivery end 18 of the syringe 10 and immediately adjacent to the enlarged portion 11 of the syringe barrel 12.
  • the piston 32 when it is desired to mix the ingredients, the piston 32 is withdrawn into the enlarged portion 11 of the syringe barrel 12 to provide a flow path between the two chambers A, B thereby permitting the separate ingredients to mix.
  • the cap 20 is threaded onto the tubular boss 17 extending from the distal end 18 of the syringe barrel 12, and the syringe container 10 is placed in a vertical position with the open end 22 facing upwardly.
  • a predetermined amount of one desired ingredient, a powder, for example, is then measured into the lower portion B of the syringe barrel 12.
  • the plunger 13 is then inserted until the proximal piston 14 is just above the opening 22 of the syringe barrel 12.
  • a second ingredient which may be a liquid, is 10 then placed into the upper portion A of the syringe barrel 12, and the plunger 13 is then depressed until the distal piston 15 is adjacent to but does not extend into the enlarged portion 11 of the syringe barrel 12.
  • a locking device such as previously described is then placed over the plunger shaft 16 to immobilize the plunger 13 and associated pistons 14, 15.
  • a two-compartment syringe container 10 is formed having a powder in the lower portion B which is defined by the syringe barrel 12, the delivery end 18 of the syringe barrel 12 and the distal piston 15 of the plunger 13, and a liquid in the upper portion A which is defined by the spaced plunger pistons 14, 15 and the syringe barrel 12.
  • the combined syringe and container 10 may thus be transported and stored until ready for use.
  • the lock washer 23 is removed and the plunger 13 is depressed until the distal piston 15 extends into the enlarged portion 11 of the syringe barrel 12, as illustrated in FIGURE 2. This provides a flow path between the two portions A, B of the syringe barrel 12, thus permitting the two ingredients to mix.
  • the cap 20 is removed from the tubular boss 17 and a needle 21 is threaded onto the boss 17. The mixed ingredients are then injected in the usual fashion.
  • a combined syringe and plural compartment container comprising:
  • an elongated syringe barrel having a delivery end and an open end and an enlarged portion of greater diameter than the syringe barrel extending around its periphery at a point intermediate its ends;
  • a plunger slidably disposed within said syringe barrel, said plunger having at least one piston affixed thereto, the piston slidably and sealingly engaging the syringe barrel and defining, with the syringe barrel, at least one compartment on either side of said enlarged portion of the syringe barrel;
  • sealing means closing the delivery end of the syringe barrel
  • a cover closing the open end of the syringe barrel, said cover having an opening therein, the plunger extending through said opening in the cover and having a slot in the shaft thereof immediately adjacent to the cover when the plunger is in the extended position;
  • the combined syringe and plural compartment container of claim 1 including a tubular boss extending from the delivery end thereof and engageable with a needle.
  • a combined syringe and plural compartment container comprising:
  • an elongated syringe barrel having a delivery end and an open end and an enlarged portion of greater diameter than the syringe barrel extending around its periphery at a point intermediate its ends;
  • a plunger slidably disposed within said syringe barrel, said plunger having two spaced apart pistons thereon and a slot in the shaft thereof adjacent the proximal piston, the pistons slidably and sealingly engaging the syringe barrel and defining, with the syringe barrel, at least one compartment on either side of said enlarged portion of the syringe barrel;
  • sealing means closing the delivery end of the syringe barrel
  • releasable locking means interengaging the open end of the syringe barrel and the plunger to prevent movement of the plunger during transportation and storage
  • said releasable locking means being a hinged lock washer swingably fastened to the open end of the syringe barrel and removably engageable with said slot when the plunger is in the extended position.
  • the combined syringe and plural compartment container of claim 3 including a tubular boss extending from the delivery end thereof and engageable with a needle.

Description

Nov. 11, 1969 L. E. wALEcKA COMBINED MIXING SYRINGE AND CONTAINER Filed Feb- 5, 1967 ELIE IIIIIIIIIIIII LEONARD E.WALECKA United States Patent M US. Cl. 128-218 4 Claims ABSTRACT OF THE DISCLOSURE A combined syringe and plural-compartment container for storing solid and liquid ingredients separately for subsequent mixing and injection. The syringe barrel includes an enlarged portion around its periphery at about the center of its longitudinal dimension, and together with the syringe pistons forms a plural-compartment container. When two pistons are used, one of the pistons is positioned immediately adjacent to the enlarged portion of the syringe barrel and the other seals off the open end of the barrel, thus forming two compartments, each of which may contain a different ingredient. By depressing the syringe plunger slightly so that the one piston extends into the enlarged portion of the barrel, a flow path is provided whereby the two ingredients can mix. Lock means are also provided in order to prevent accidental displacement of the plunger during transport and storage.
BACKGROUND OF THE INVENTION Many pharmaceutical preparations are unstable when dissolved or suspended in their carriers or vehicles and consequently must be kept separated until immediately prior to use, whereupon they must be mixed, placed in a syringe, and then injected. Each step which exposes the ingredients or the hypodermic needle presents a risk of contamination.
SUMMARY DRAWINGS The apparatus will be better understood upon consideration of the following description with reference to the following drawings, in which:
,. FIGURE 1 is a side elevational view in cross-section of a two-compartment syringe and container showing the two ingredients as separated.
FIGURE 2 is a partial side elevational view in crosssection showing the syringe plunger in position to permit mixing of the ingredients.
FIGURE 3 is a side elevational view, partially broken away in cross-section showing a hypodermic needle attached to the syringe and the plunger depressed for injection.
FIGURE 4 is a partial cross-sectional view taken along the line 44 of FIGURE 1 and showing a locking and tamperproof seal.
FIGURE 5 is a cross-sectional view taken along the line 5-5 of FIGURE 4.
FIGURE 6 is a partial cross-sectional view showing another embodiment.
3,477,431 Patented Nov. 11, 1969 FIGURE 7 is a partial cross-sectional. view taken along the line 7-7 of FIGURE 6 and showing another embodiment of the locking feature.
DETAILED DESCRIPTION Referring to FIGURE 1, there is shown a two-compartment syringe and container 10 having an enlarged center portion 11 extending around the periphery of the syringe barrel 12. As shown in the drawings, the enlarged portion 11 is of greater diameter than the syringe barrel 12 proper and may be of any desired cross-section. The package includes a plunger 13 having two spaced pistons 14,15 on the shaft 16 thereof and a threaded, tubular boss 17 on the distal or delivery end 18 of the syringe barrel 12. The boss 17 includes a passage 19 which connects the interior of the syringe barrel 12 with the outer portion of the boss 17. During transport and storage, the tubular boss 17 and passage 19 therein are sealed by a cap 20. When it is desired to inject the ingredients in the syringe, the cap 20 is removed and a needle 21 is threaded onto the boss 17. If desired, a cannula suitable for puncturing a stopper may be employed in place of the needle 21.
During transport and storage, the plunger 13 must be immobilized in order to prevent accidental displacement of the distal plunger piston 15 into the enlarged portion 11 of the syringe barrel 12 since such displacement would permit undesired mixing of the ingredients. One means for immobilizing the plunger is to employ a. lock washer seal. In the embodiment illustrated in FIGURES 1, 2, and 3, the syringe barrel 12 has an open end 22 on the proximal end thereof. In this type of structure, the tamperproof seal and locking device 23 illustrated in detail in FIG- URES 4 and 5 may be employed. In this device, a hinged lock washer 24 is fastened to the syringe barrel 12 by means of a bracket 25 and pivot pin 26. The lock Washer 24 fits into a slot 27 in the plunger shaft 16, thereby preventing longitudinal movement of the plunger 13. To prevent undesired release of the lock Washer 24, an extended portion 28 may be provided, which portion engages a slotted bracket 29 fastened to the syringe barrel 12. When it is desired to mix the ingredients, the lock washer 24 is released (shown in phantom lines in FIGURE 4) to permit movement of the plunger 13 and associated pistons 14, 15.
Another embodiment of the device of this invention which employs a single piston and a different locking device is illustrated in FIGURES 6 and 7. In this embodiment, the open end 22 of the syringe barrel 12 is closed by a cover 30 through which the shaft 16 of the plunger 13 extends. As illustrated, the plunger shaft 16 is of cruciform cr0ss-section and has a slot therein (not shown) immediately adjacent to the cover 30 when the plunger 13 is in the extended position as shown in FIGURE 1. Into the slot is fitted a lock washer 31 which abuts against the cover 30, thereby preventing movement of the plunger 13. When it is desired to mix the ingredients, the locking device is removed to permit movement of the plunger 13.
In this embodiment, since a cover 30 is used to seal the open end 22 of the syringe barrel 12, a single piston 32can be utilized to divide the syringe barrel 12 into two compartments. The piston 32 can be disposed on either side of the enlarged portion 11 of the syringe barrel 12. As shown in FIGURE 6, the piston 32 is disposed toward the delivery end 18 of the syringe 10 and immediately adjacent to the enlarged portion 11 of the syringe barrel 12. In this embodiment, when it is desired to mix the ingredients, the piston 32 is withdrawn into the enlarged portion 11 of the syringe barrel 12 to provide a flow path between the two chambers A, B thereby permitting the separate ingredients to mix.
To prepare the syringe container for use, the cap 20 is threaded onto the tubular boss 17 extending from the distal end 18 of the syringe barrel 12, and the syringe container 10 is placed in a vertical position with the open end 22 facing upwardly. A predetermined amount of one desired ingredient, a powder, for example, is then measured into the lower portion B of the syringe barrel 12. The plunger 13 is then inserted until the proximal piston 14 is just above the opening 22 of the syringe barrel 12. A second ingredient, which may be a liquid, is 10 then placed into the upper portion A of the syringe barrel 12, and the plunger 13 is then depressed until the distal piston 15 is adjacent to but does not extend into the enlarged portion 11 of the syringe barrel 12. A locking device such as previously described is then placed over the plunger shaft 16 to immobilize the plunger 13 and associated pistons 14, 15. Thus, as illustrated by FIG- URE 1, a two-compartment syringe container 10 is formed having a powder in the lower portion B which is defined by the syringe barrel 12, the delivery end 18 of the syringe barrel 12 and the distal piston 15 of the plunger 13, and a liquid in the upper portion A which is defined by the spaced plunger pistons 14, 15 and the syringe barrel 12. The combined syringe and container 10 may thus be transported and stored until ready for use.
When it is desired to mix and inject the ingredients, the lock washer 23 is removed and the plunger 13 is depressed until the distal piston 15 extends into the enlarged portion 11 of the syringe barrel 12, as illustrated in FIGURE 2. This provides a flow path between the two portions A, B of the syringe barrel 12, thus permitting the two ingredients to mix. After the ingredients are adequately mixed, the cap 20 is removed from the tubular boss 17 and a needle 21 is threaded onto the boss 17. The mixed ingredients are then injected in the usual fashion.
While one of the ingredients has been shown as a powder, all of the ingredients can be liquid. Further, when the device of the present invention is made of molded plastic and is loaded under sterile conditions, it provides an inexpensive and convenient package for injectable fluids.
While particular embodiments of the invention have been shown and described, it is not intended to be limited to the exact details of the structures shown, but it is intended to include other changes and modifications which may come within the scope of the appended claims.
What is claimed is:
1. A combined syringe and plural compartment container comprising:
an elongated syringe barrel having a delivery end and an open end and an enlarged portion of greater diameter than the syringe barrel extending around its periphery at a point intermediate its ends;
a plunger slidably disposed within said syringe barrel, said plunger having at least one piston affixed thereto, the piston slidably and sealingly engaging the syringe barrel and defining, with the syringe barrel, at least one compartment on either side of said enlarged portion of the syringe barrel;
sealing means closing the delivery end of the syringe barrel;
a cover closing the open end of the syringe barrel, said cover having an opening therein, the plunger extending through said opening in the cover and having a slot in the shaft thereof immediately adjacent to the cover when the plunger is in the extended position;
and a lock washer removably fitted within the slot in the shaft of the plunger when the plunger is in the extended position and abutting the cover on the outer surface thereof to thereby prevent movement of the plunger during transportation and storage.
2. The combined syringe and plural compartment container of claim 1 including a tubular boss extending from the delivery end thereof and engageable with a needle.
3. A combined syringe and plural compartment container comprising:
an elongated syringe barrel having a delivery end and an open end and an enlarged portion of greater diameter than the syringe barrel extending around its periphery at a point intermediate its ends;
a plunger slidably disposed within said syringe barrel, said plunger having two spaced apart pistons thereon and a slot in the shaft thereof adjacent the proximal piston, the pistons slidably and sealingly engaging the syringe barrel and defining, with the syringe barrel, at least one compartment on either side of said enlarged portion of the syringe barrel;
sealing means closing the delivery end of the syringe barrel;
and releasable locking means interengaging the open end of the syringe barrel and the plunger to prevent movement of the plunger during transportation and storage, said releasable locking means being a hinged lock washer swingably fastened to the open end of the syringe barrel and removably engageable with said slot when the plunger is in the extended position.
4. The combined syringe and plural compartment container of claim 3 including a tubular boss extending from the delivery end thereof and engageable with a needle.
References Cited UNITED STATES PATENTS 1,231,442 6/ 1917 Smith 222-402 XR 2,147,616 2/1939 Chaput 128218.1 2,489,040 11/ 1949 Lawsche l28-218 2,704,072 3/1955 Sarnoff 128-2l8.1 3,058,467 10/1962 Faure 128-218 RICHARD A. GAUDET, Primary Examiner M. F. MAJESTIC, Assistant Examiner US. Cl. X.R. l28272
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Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3662753A (en) * 1970-05-25 1972-05-16 Kitchener B Tassell Syringe
US3881484A (en) * 1973-07-05 1975-05-06 Jr Charles F Gidcumb Mixing syringe having a rotationally restrained piston rod
US3889674A (en) * 1973-11-30 1975-06-17 Constabile A Cilento Mixing syringe
US3985122A (en) * 1975-06-04 1976-10-12 Medical Development Corporation Multi-piston syringe device
US4102451A (en) * 1977-05-25 1978-07-25 Eli Lilly And Company Mixing vial
US4116240A (en) * 1977-03-11 1978-09-26 Guiney Aeneas C Mixing syringe
US4116354A (en) * 1977-01-24 1978-09-26 Colgate-Palmolive Company Two chambered mixing container
US4226236A (en) * 1979-05-07 1980-10-07 Abbott Laboratories Prefilled, vented two-compartment syringe
US4449645A (en) * 1981-06-15 1984-05-22 Paul Korwin Dental container and amalgam dispensing method
US4470505A (en) * 1983-01-26 1984-09-11 Paul Korwin Method and apparatus for storing, mixing and delivering dental amalgam
US4518386A (en) * 1983-08-31 1985-05-21 Tartaglia John A Medicine container having lyophilized powder and diluent stored in separate sealed chambers
US4599082A (en) * 1984-08-13 1986-07-08 Becton, Dickinson And Company Two-component syringe assembly
US4776704A (en) * 1986-12-15 1988-10-11 Dentsply Research & Development Corp. Mixing and dispensing syringe
DE8907336U1 (en) * 1989-06-15 1990-10-18 Espe Stiftung & Co Produktions- Und Vertriebs Kg, 8031 Seefeld, De
US4994043A (en) * 1987-06-16 1991-02-19 Akzo N.V. Two compartment syringe
US5122117A (en) * 1990-06-05 1992-06-16 Habley Medical Technology Corp. Component mixing syringe
US5149320A (en) * 1988-04-11 1992-09-22 Dhaliwal Avtar S Composite anesthetic article and method of use
US5240322A (en) * 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with rotatable vaned internal magnetic mixing element
US5423791A (en) * 1992-03-31 1995-06-13 Bartlett; J. Mark Valve device for medical fluid transfer
US5634714A (en) * 1995-06-28 1997-06-03 Guild; William Fluid mixing and dispensing system for the rapid mixing of a prestored substance with a fluid and the dispensing thereof
US5665066A (en) * 1993-09-03 1997-09-09 Ultradent Products, Inc. Methods and apparatus for mixing and dispensing multi-part compositions
US5716338A (en) * 1993-10-20 1998-02-10 Pharmacia & Upjohn Aktiebolag Dual-chamber type injection cartridge with bypass connection
US6045254A (en) * 1996-12-26 2000-04-04 M.L.I.S. Projects Ltd. Container having two or more compartments
US6113257A (en) * 1996-12-26 2000-09-05 M.L.I.S. Projects Ltd. Two-compartment container
WO2003018404A1 (en) * 2001-07-19 2003-03-06 M.L.I.S. Projects Ltd. Method and apparatus for filling a multi-compartment container
US6626870B1 (en) * 2000-03-27 2003-09-30 Artix Laboratories, Inc. Stoppering method to maintain sterility
US20030195489A1 (en) * 1999-09-24 2003-10-16 Atrix Laboratories, Inc. Coupling syringe system and methods for obtaining a mixed composition
US20040122359A1 (en) * 2002-09-17 2004-06-24 Kyphon Inc. Apparatus and methods for mixing two components
US20050061688A1 (en) * 2001-07-13 2005-03-24 Antonio Palamara Disposable packaging for a ready-made food product
US20060054636A1 (en) * 2004-09-10 2006-03-16 Brennan Robert C Dual fluid cartridge for storing and dispensing fluids in unequal ratios
US20060144858A1 (en) * 2003-06-09 2006-07-06 Brennan Robert C Dual fluid cartridge assembly
US20060151530A1 (en) * 2005-01-08 2006-07-13 Horner Terry A Dual fluid cartridge with reduced fluid waste
US20060158957A1 (en) * 2001-07-16 2006-07-20 Stryker Instruments Bone cement mixing and delivery device with releasable mixing blade
WO2007034020A1 (en) * 2005-09-19 2007-03-29 Elastomeric Systems S.L. Unit for mixing and supplying injectable substances
US20070228076A1 (en) * 2006-03-29 2007-10-04 Horner Terry A Single dose dual fluid cartridge for use with hand-held applicators
US20070250013A1 (en) * 2006-03-31 2007-10-25 Brennan Robert C Self-contained single dose dual fluid dispenser
US20080234632A1 (en) * 2004-03-23 2008-09-25 Mitsuru Hasegawa Pre-Filled Syringe
US20090014449A1 (en) * 2005-09-27 2009-01-15 Alexander Dverin Multi-Compartment Storage and Mixing Vessel
US7481333B2 (en) 2006-03-20 2009-01-27 Nordson Corporation Propellant actuated dual fluid cartridge
US20110114592A1 (en) * 2010-11-12 2011-05-19 Diversified Solutions, Inc. Storage accessory for preventing oxidation of contents stored within a container
AU2010101255B4 (en) * 2010-11-15 2011-09-22 Lumsden, Andrew A prefilled syringe for administering buffered lignocaine
US20120095392A1 (en) * 2010-10-14 2012-04-19 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (pd) solutions with integrated inter-chamber diffuser
US8226598B2 (en) 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
US20120275258A1 (en) * 2011-04-27 2012-11-01 Doron Rigel Mixing tumbler
WO2015134267A1 (en) 2014-03-06 2015-09-11 Ethicon, Inc. Methods and devices for forming biomedical coatings using variable mixing ratios of multi-part compositions
WO2018126005A1 (en) * 2017-01-02 2018-07-05 Toddy Tech, LLC Tumbler lid with reservoir and repetitive measuring and disbursement mechanism
US10421590B2 (en) 2017-01-02 2019-09-24 Toddy Tech, LLC Tumbler lid with reservoir and repetitive measuring and disbursement mechanism
US20200261066A1 (en) * 2017-10-06 2020-08-20 Ancestry.Com Dna, Llc Systems, devices, and methods for sample collection
US20210002058A1 (en) * 2018-04-16 2021-01-07 Sika Technology Ag System for packaging two components
US10935406B1 (en) 2019-08-16 2021-03-02 Toddy Tech, LLC Beverage container lid with reservoir and repetitive measuring and disbursement mechanism
US11103639B1 (en) * 2021-01-16 2021-08-31 Xiaodi Chen Two-component syringe
US11826027B2 (en) 2017-03-15 2023-11-28 Ancestry.Com Dna, Llc Sample collection device and method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1231442A (en) * 1916-01-21 1917-06-26 Sidney J Smith Fire-extinguisher.
US2147616A (en) * 1937-07-09 1939-02-14 Elmer J Chaput Dental and medical hypodermic syringe
US2489040A (en) * 1946-02-14 1949-11-22 Becton Dickinson Co Holder
US2704072A (en) * 1953-08-27 1955-03-15 Stanley J Sarnoff Means for making hypodermic injections
US3058467A (en) * 1958-10-27 1962-10-16 Faure Jean-Marie Hypodermic syringes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1231442A (en) * 1916-01-21 1917-06-26 Sidney J Smith Fire-extinguisher.
US2147616A (en) * 1937-07-09 1939-02-14 Elmer J Chaput Dental and medical hypodermic syringe
US2489040A (en) * 1946-02-14 1949-11-22 Becton Dickinson Co Holder
US2704072A (en) * 1953-08-27 1955-03-15 Stanley J Sarnoff Means for making hypodermic injections
US3058467A (en) * 1958-10-27 1962-10-16 Faure Jean-Marie Hypodermic syringes

Cited By (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3662753A (en) * 1970-05-25 1972-05-16 Kitchener B Tassell Syringe
US3881484A (en) * 1973-07-05 1975-05-06 Jr Charles F Gidcumb Mixing syringe having a rotationally restrained piston rod
US3889674A (en) * 1973-11-30 1975-06-17 Constabile A Cilento Mixing syringe
US3985122A (en) * 1975-06-04 1976-10-12 Medical Development Corporation Multi-piston syringe device
US4116354A (en) * 1977-01-24 1978-09-26 Colgate-Palmolive Company Two chambered mixing container
US4116240A (en) * 1977-03-11 1978-09-26 Guiney Aeneas C Mixing syringe
US4102451A (en) * 1977-05-25 1978-07-25 Eli Lilly And Company Mixing vial
US4226236A (en) * 1979-05-07 1980-10-07 Abbott Laboratories Prefilled, vented two-compartment syringe
US4449645A (en) * 1981-06-15 1984-05-22 Paul Korwin Dental container and amalgam dispensing method
US4470505A (en) * 1983-01-26 1984-09-11 Paul Korwin Method and apparatus for storing, mixing and delivering dental amalgam
US4518386A (en) * 1983-08-31 1985-05-21 Tartaglia John A Medicine container having lyophilized powder and diluent stored in separate sealed chambers
US4599082A (en) * 1984-08-13 1986-07-08 Becton, Dickinson And Company Two-component syringe assembly
US4776704A (en) * 1986-12-15 1988-10-11 Dentsply Research & Development Corp. Mixing and dispensing syringe
US4994043A (en) * 1987-06-16 1991-02-19 Akzo N.V. Two compartment syringe
US5149320A (en) * 1988-04-11 1992-09-22 Dhaliwal Avtar S Composite anesthetic article and method of use
DE8907336U1 (en) * 1989-06-15 1990-10-18 Espe Stiftung & Co Produktions- Und Vertriebs Kg, 8031 Seefeld, De
US5058770A (en) * 1989-06-15 1991-10-22 Thera Patent Gmbh & Co. Kg Gesellschaft Fuer Industrielle Schutzrechte Container for substances prepared by mixing components
US5122117A (en) * 1990-06-05 1992-06-16 Habley Medical Technology Corp. Component mixing syringe
US5423791A (en) * 1992-03-31 1995-06-13 Bartlett; J. Mark Valve device for medical fluid transfer
US5240322A (en) * 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with rotatable vaned internal magnetic mixing element
US5665066A (en) * 1993-09-03 1997-09-09 Ultradent Products, Inc. Methods and apparatus for mixing and dispensing multi-part compositions
US5716338A (en) * 1993-10-20 1998-02-10 Pharmacia & Upjohn Aktiebolag Dual-chamber type injection cartridge with bypass connection
US5634714A (en) * 1995-06-28 1997-06-03 Guild; William Fluid mixing and dispensing system for the rapid mixing of a prestored substance with a fluid and the dispensing thereof
US5863126A (en) * 1995-06-28 1999-01-26 Guild; William Fluid mixing and dispensing system for the rapid mixing of a prestored substance with a fluid and the dispensing thereof
US6045254A (en) * 1996-12-26 2000-04-04 M.L.I.S. Projects Ltd. Container having two or more compartments
US6113257A (en) * 1996-12-26 2000-09-05 M.L.I.S. Projects Ltd. Two-compartment container
US8226598B2 (en) 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
US20030195489A1 (en) * 1999-09-24 2003-10-16 Atrix Laboratories, Inc. Coupling syringe system and methods for obtaining a mixed composition
US6626870B1 (en) * 2000-03-27 2003-09-30 Artix Laboratories, Inc. Stoppering method to maintain sterility
US6575208B2 (en) 2000-04-04 2003-06-10 M.L.I.S. Projects Ltd. Method and apparatus for filling a multi-compartment container
US7163102B2 (en) * 2001-07-13 2007-01-16 Antonio Palamara Disposable packaging for a ready-made food product
US20050061688A1 (en) * 2001-07-13 2005-03-24 Antonio Palamara Disposable packaging for a ready-made food product
US20060158957A1 (en) * 2001-07-16 2006-07-20 Stryker Instruments Bone cement mixing and delivery device with releasable mixing blade
US7320540B2 (en) * 2001-07-16 2008-01-22 Stryker Corporation Bone cement mixing and delivery device with releasable mixing blade
WO2003018404A1 (en) * 2001-07-19 2003-03-06 M.L.I.S. Projects Ltd. Method and apparatus for filling a multi-compartment container
US20040122359A1 (en) * 2002-09-17 2004-06-24 Kyphon Inc. Apparatus and methods for mixing two components
US7018089B2 (en) * 2002-09-17 2006-03-28 Kyphon Inc. Apparatus and methods for mixing two components
US20060144858A1 (en) * 2003-06-09 2006-07-06 Brennan Robert C Dual fluid cartridge assembly
US7506783B2 (en) 2003-06-09 2009-03-24 Nordson Corporation Dual fluid cartridge assembly
US20080234632A1 (en) * 2004-03-23 2008-09-25 Mitsuru Hasegawa Pre-Filled Syringe
US7237693B2 (en) 2004-09-10 2007-07-03 Tah Industries, Inc. Dual fluid cartridge for storing and dispensing fluids in unequal ratios
US20060054636A1 (en) * 2004-09-10 2006-03-16 Brennan Robert C Dual fluid cartridge for storing and dispensing fluids in unequal ratios
US20060151530A1 (en) * 2005-01-08 2006-07-13 Horner Terry A Dual fluid cartridge with reduced fluid waste
US7497355B2 (en) 2005-01-08 2009-03-03 Nordson Corporation Dual fluid cartridge with reduced fluid waste
WO2007034020A1 (en) * 2005-09-19 2007-03-29 Elastomeric Systems S.L. Unit for mixing and supplying injectable substances
US20090014449A1 (en) * 2005-09-27 2009-01-15 Alexander Dverin Multi-Compartment Storage and Mixing Vessel
US7866465B2 (en) * 2005-09-27 2011-01-11 Alexander Dverin Multi-compartment storage and mixing vessel
US7481333B2 (en) 2006-03-20 2009-01-27 Nordson Corporation Propellant actuated dual fluid cartridge
US7748567B2 (en) 2006-03-29 2010-07-06 Nordson Corporation Single dose dual fluid cartridge for use with hand-held applicators
US20070228076A1 (en) * 2006-03-29 2007-10-04 Horner Terry A Single dose dual fluid cartridge for use with hand-held applicators
US20070250013A1 (en) * 2006-03-31 2007-10-25 Brennan Robert C Self-contained single dose dual fluid dispenser
US10842714B2 (en) 2010-10-14 2020-11-24 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter chamber diffuser
US20120095392A1 (en) * 2010-10-14 2012-04-19 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (pd) solutions with integrated inter-chamber diffuser
US9585810B2 (en) * 2010-10-14 2017-03-07 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser
US11779519B2 (en) 2010-10-14 2023-10-10 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser
US20110114592A1 (en) * 2010-11-12 2011-05-19 Diversified Solutions, Inc. Storage accessory for preventing oxidation of contents stored within a container
AU2010101255B4 (en) * 2010-11-15 2011-09-22 Lumsden, Andrew A prefilled syringe for administering buffered lignocaine
US20120275258A1 (en) * 2011-04-27 2012-11-01 Doron Rigel Mixing tumbler
US9186637B2 (en) * 2011-04-27 2015-11-17 Doron Rigel Mixing tumbler
WO2015134267A1 (en) 2014-03-06 2015-09-11 Ethicon, Inc. Methods and devices for forming biomedical coatings using variable mixing ratios of multi-part compositions
US10085729B2 (en) 2014-03-06 2018-10-02 Ethicon, Inc. Methods and devices for forming biomedical coatings using variable mixing ratios of multi-part compositions
US10828018B2 (en) 2014-03-06 2020-11-10 Ethicon, Inc. Methods and devices for forming biomedical coatings using variable mixing rations of multi-part compositions
WO2018126005A1 (en) * 2017-01-02 2018-07-05 Toddy Tech, LLC Tumbler lid with reservoir and repetitive measuring and disbursement mechanism
US10421590B2 (en) 2017-01-02 2019-09-24 Toddy Tech, LLC Tumbler lid with reservoir and repetitive measuring and disbursement mechanism
US10112752B2 (en) 2017-01-02 2018-10-30 Toddy Tech, LLC Tumbler lid with reservoir and repetitive measuring and disbursement mechanism
US11826027B2 (en) 2017-03-15 2023-11-28 Ancestry.Com Dna, Llc Sample collection device and method
US20200261066A1 (en) * 2017-10-06 2020-08-20 Ancestry.Com Dna, Llc Systems, devices, and methods for sample collection
US10973497B2 (en) * 2017-10-06 2021-04-13 Ancestry.Com Dna, Llc Systems, devices, and methods for sample collection
US20210002058A1 (en) * 2018-04-16 2021-01-07 Sika Technology Ag System for packaging two components
US11428562B2 (en) 2019-08-16 2022-08-30 Toddy Tech, LLC Beverage container lid with reservoir and repetitive measuring and disbursement mechanism
US20220412786A1 (en) 2019-08-16 2022-12-29 Toddy Tech, LLC Beverage container lid with reservoir and repetitive measuring and disbursement mechanism
US11768096B2 (en) 2019-08-16 2023-09-26 Toddy Tech, LLC Beverage container lid with reservoir and repetitive measuring and disbursement mechanism
US10935406B1 (en) 2019-08-16 2021-03-02 Toddy Tech, LLC Beverage container lid with reservoir and repetitive measuring and disbursement mechanism
US11103639B1 (en) * 2021-01-16 2021-08-31 Xiaodi Chen Two-component syringe

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