|Publication number||US3527220 A|
|Publication date||Sep 8, 1970|
|Filing date||Jun 28, 1968|
|Priority date||Jun 28, 1968|
|Publication number||US 3527220 A, US 3527220A, US-A-3527220, US3527220 A, US3527220A|
|Inventors||Summers George Donald|
|Original Assignee||Fairchild Hiller Corp|
|Export Citation||BiBTeX, EndNote, RefMan|
|Referenced by (157), Classifications (8)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent Inventor George Donald Summers Stony Brook, New York Appl. No. 741,117
Filed June 28, 1968 Patented Sept. 8, 1970 Assignee Fairchlld Hiller Corporation Farmingdale, 12.1., New York a corporation of Maryland IMPLANTABLE DRUG ADMINISTRATOR 15 Claims, 5 Drawing Figs.
U.S. Cl 128/260, 3/1, 128/15, 128/273 Int. Cl. A61m 7/00 Field of Search 128/260,
[561 References Cited UNITED STATES PATENTS 2,625,158 1/1953 Lee et a1. 128/260 3,313,289 4/1967 Kapra1.... 3/1 3,443,561 5/1969 Reed 128/260 Primary Examiner-Adele M. Eager Attorney-Michael W. York ABSTRACT: An implantable drug administrator comprises a bladder having a self-sealing port through which it can be filled with a drug, a pump for selectively pumping the drug 7 from the bladder into any desired area of the body, and an indicator for indicating when the desired amount of the drug has been injected.
Patented Sept. 8, 1970 v 3,527,220
INVENTOR GEORGE DONALD SUMMERS ATTORNEYS IMPLANTABLE DRUG ADMINISTRATOR This invention relates to a device which can be implanted within an animal body for administering drugs or the like.
It has been proposed to implant a reservoir containing a drug or other medical preparation within a body cavity for purposes of administering the drug. to an animal. In such arrangements, the drug is generally permitted to escape into the body through perforations in the container or by diffusion through the container itself.
The prior art devices for this purpose have only attained limited utility principally because of their lack of reliability due, at least in part, to clogging of the container, and the obvious inconvenience of replacing an implantable container every time its drug supply is exhausted. Further drawbacks are the inability to situate the container in any desired area of the body while releasing the drug in a distant area ofthe body, and the lack of a practical monitoring device for assuring the proper operation of the system.
The present invention provides an improved implantable drug administration system which avoids the foregoing drawbacks and therefore is more reliable, easier to use, and of wider utility than known devices of this type.
Briefly, according to the invention, a drug is pumped from an implanted bladder by means of an implanted pump which is powered by an extra-corporeal magnetic field. The bladder includes a self-sealing port through which it can be refilled whenever desired. An implanted light source indicates the rate at which the drug is being pumped and thus can also be used to indicate the total dosage administered.
In the drawings:
FIG. 1 is a diagrammatic view showing how the invention typically would be implanted within the body ofa human;
FIG. 2 is a perspective view of the invention prior to being implanted;
FIG. 3 is a circuit diagram of the indicator circuit used in the preferred embodiment of the invention;
FIG. 4 is a detailed cross-sectional view of the inlet tube of the invention illustrated in FIG. 2; and
FIG. 5 is a detailed broken sectional view of the switch and the pump ofthe invention illustrated in FIG. 2.
In the specification and claims, the term "drug" is used in the broadest sense and includes all therapeutic and diagnostic agents such as hormones, vitamins, antibiotics, anticoagulants, cancericidal and spermicidal agents, vasoactive agents, and all other substances used to control, treat, or diagnose, or otherwise affect, physical or mental conditions (normal and abnormal) existing in and/or on an animal body.
Referring to FIGS. 1 and 2, the invention is shown as comprising a bladder and a pump 12 having an inlet line 14 connected to the lowermost point of bladder 10. The bladder 10 and pump 12 may be sutured in place within the abdominal cavity 16 of an individual, with a pump outlet line 18 leading into that portion of the body where it is desired to administer the drug.
Bladder 10 includes a port 20 which is self sealing and readily accessible from outside the individuals body although the port may be underneath the skin. A miniature light source 22 is sewn to bladder 10 within abdominal cavity 16, and, when energized, can be observed through the individuals skin. As explained below, light source 22 provides an indication of the dosage or amount of the drug within bladder 10 administered by the pump 12.
In the preferred embodiment of the invention, pump 12 is of the type disclosed in the May/June 1967 issue of The Journal of the Association for the Advancement of Medical Instrumentation, in an article entitled A New Miniature Pump for the Treatment of Hydrocephalus" by Summers and Mathews. As explained in that article, pump 12 includes a rotor assembly which is coupled through a gear train to a rotatable magnetic disc. The rotor contains three peripheral rollers which cyclically compress a length of tubing between the pump inlet 14 and outlet l8 with a peristatic action, thereby forcing fluid from inlet 14 to outlet 18. Since this construction is known, it is not illustrated and described here in detail.
The pump is driven by a rotatable magnet 24 located outside the body and rotated by a motor 26 suitably coupled thereto. The rotation of magnet 24 rotates the pump magnet by the pull of its magnetic field thus pumping the drug from bladder 10 through pump inlet tube 14 and outlet tube 18. This particular pump is highly desirable since it can be powered without penetrating the skin (exclusive of implantation), the advantages of which are self-evident. The specific pump per se, however, forms no part of this invention. The manner in which the invention is employed is obvious from the preceding explanation. After the bladder 10 and pump 12 have been implanted, the drug to be administered is injected into the bladder by means of a hypodermic needle and syringe or the like inserted through the seal-sealing plug 20. Thereafter, whenever it is desired to administer the drug, the motor 26 is energized to rotate magnet 24 thus driving pump 12 as explained above. The operation of the pump will cause the drug within bladder 10 to be administered through the distal end of outlet tube 18 wherever it is positioned.
The light source 22 may be energized a predetermined number of times during each revolution of the pump rotor to indicate that the pump is operating and to provide a measure of the dosage administered.
FIG. 2 shows certain specific details of the bladder 10, pump 12 and the energizing means for lamp 22. The pump is retained within a sealed stainless steel (or plastic) casing 30 which includes a flange 32 having apertures 34 by means of which the pump may be sewn into the body. A coil 36 is wrapped around a diameter of casing 30, with the coil leads 37 and 38 coupled, respectively to a miniature switch 40 within casing 30 and to the-lamp 22. Switch 40 (shown diagrammatically in FIG. 3) is a single-pole, single-throw (normally open) switch which can be closed in any suitable fashion each time a roller of the pump rotor traverses the pump tubing between inlet 14 and outlet 18. The operation of a preferred embodiment of switch 40 is explained below with reference to FIG. 5.
When the magnet 24 is rotated by motor 26, the resultant rotating magnetic field intersects coil 36 inducing a current in the coil. Accordingly, each time the contacts of switch 40 are closed, an energizing current is coupled to the light source 22. Thus, the energization of the light, which can be seen through the skin, indicates that the pump is operating properly. Since the volume amount of the drug displaced between successive rollers by rotation of the pump rotor is known, the flashes of light source 22 can be counted to measure the total administered dosage of the drug.
The bladder 10 includes an inner layer 50 coated with an outer layer 52 which is compatible with animal tissue. Various silicone rubber compositions are suitable for use as layer 52, representative examples being given in US Pat. No. 3,279,996 of Long. Since diffusion may occur through a silicone rubber layer, the inner layer 50 must be impervious to and not degraded by the drug used. Standard latex rubber is suitable for many purposes as the material of inner layer 50. The use of the silicone rubber layer provides a degree of selfsealing in the event the bladder is accidentally punctured during filling.
The self-sealing port 20 comprises a ring 54 made of a tissue compatible material such as a polycarbonate resin or stainless steel filled with a silicone rubber material 56 to a depth of about .25 inches. If necessary, an inner layer (not shown) of a material impervious to the drug may be used. The raised ring 54 enables the doctor to locate the port 20 through the skin. Where ring 54 is made of magnetically permeable material it can be located by a common stud finder or the like.
A stiff plastic or metal striker plate 58 is bonded to the interior layer 50 opposite port 20 as protection against accidental puncture of the bladder during injection of the drug. To ensure injection of the drug into the bladder, the inner surface of the port may be made concave so that there will always be a space between the port and striker plate 58.
As noted previously, the invention is not limited to any specific drug, and the drugs may be administered directly into tissue, organs, muscle, or body fluid (including blood). The
particular function in this respect will determine the size and construction of the needle or other termination of the outlet tube 18. As a specific example tube 18 may terminate in a rounded end 62 having side slots 64 through which the drug is dispensed. This construction will tend to prevent body fluid from entering tube 18 without interfering with the exit of the drug. A woven tube 66 (for example, of Dacron) may be bonded to the exterior surface of tube 18. Animal tissue will grow into tube 66 to help anchor the tube in the desired area of the body and to seal the penetration site against flow of body fluids.
The light source may comprise a diode made of gallium arsenide phosphide, requiring a forward bias of about 1.5 to 2.0 volts. It is less than a tenth of an inch in diameter and has an overall length of about an eighth of an inch, including the lens cap. It is rated at 50 foot-Lamberts brightness at a forward bias of 1.65 volts and forward current of 50 milliamperes. At that voltage it has a continuous forward current rating of 100 milliamperes.
In order to achieve maximum optical transmission through the skin, it is desirable to choose a wavelength in the zone of greatest skin transparency. However, this wavelength would be unsuitable as maximum transparency lies in the near-infrared region and is not visible to the human eye. On the other hand, the region of maximum sensitivity of the light-adapted human eye, about 570 millimicrons, is poorly transmitted through the skin. The wavelength of the selected lightemitting diode, in the 600-to-700 millimicron region, provides a compromise. The skin is reasonably transparent at this wavelength and the eye can easily detect the rich red color.
Some data on the depth of penetration of optical frequencies into the human have been reported. Penetration depth varies with skin pigmentation and is in the range of about two millimeters maximum. Data for transmission outward is not available, but in experiments the diode-emitted light was easily visible in a darkened room through chicken skin and tissue for depths of more than 8 millimeters. I
The energizing circuit for light source 22 is shown in FIG. 3. It is a simple series circuit and also includes a protective diode 70 which prevents the application of excessive back voltages to the light source 22.
In place of the coil 36, the power to operate lamp 22 may be provided by a battery or photo-voltaic cells. Also the coil 36 may be made responsive to an inductive or RF electromagnetic field.
In the preferred embodiment of the invention, the electrical leads are covered with an insulating material 72 (FIG. 4) such as Teflon and the solder joints coated with an epoxy (not shown). The wires are then bonded to the inlet tube 14 and the entire construction coated with a suitable silicone rubber composition 74.
A preferred construction for switch 40 is shown in FIG. 5. The pump includes a steel ring 80 within the pump casing 30. The pump rollers (one of which is shown at 82) compress the tubing 84 between inlet and outlet tubes 14 and 18 against ring 80. Switch 40 thus comprises the ring 80, a pressure sensitive paint 86, and a terminal 88 which is insulated from ring 80. The switch leads 37 and 37 are mechanically coupled through casing 30 (and suitably sealed) into electrical contact with ring 80 and terminal 88, respectively.
Paint 86 is ofa type which undergoes an increase in conductivity upon application of pressure thereto. (A suitable paint of this type is manufactured by Clark Electronics Laboratories of Palm Springs, California and sold under the trademark Micro-Ducer (type 9A).) Thus, each time a roller 82 passes over the terminal 88, the resultant increase in pressure closes" switch 40 to energize the light source 22.
Obviously, other switch constructions may be employed with the invention. A magnetically actuated mechanical switch would be of particular utility since it would enable a simple means for testing whether the signalling system was in proper working order by applying an external magnetic field to latch the switch in its closed condition. If, because of the magnetic fields required to operate pump 12, such a switch could not be employed in place of switch 40, a normally open switch of this type could be located at the bladder 10 and placed electrically in parallel with the contacts of switch 40. Such a switch is shown in dotted lines at in FIG. 3.
The visual signalling system of the invention would have utility in other applications apart from the specific case herein illustrated. For example, it could be used to test the continuity of circuits where breakage or interruption of leads is a problem (as with cardiac pacemakers).
Use of the invention is specifically contemplated in the treatment of diabetics or for chemotherapy of a carcinomatic condition. It could be used for the daily administration of a contraceptive, in the treatment of Hansens disease and in the administration of some hormones..The invention, however, is not in any respect limited as to its utility in special situations.
It is intended that the various parts of the invention will be sealed and coated with a tissue compatible material (such as silicone rubber) to whatever extent is required. Since silicone rubber is not a sealant, it may be necessary or desirable to coat the parts with a sealant (e.g. an epoxy) prior to applying the silicone rubber coating.
The invention can be used in many different ways to inject varying amounts of a drug ranging, for example, from microliters per day to milliliters per day. It can be used continuously and, conceivably, actuation of the pump may be made automatically responsive to a measurable body condition (e.g. oxygen partial pressure in the blood) or responsive to a programmed time schedule. The pump rotor can be made to rotate in both directions whereby a single pump can be used in conjunction with two bladders (and suitable valves) to selectively pump drugs from either bladder.
1. An implantable drug administrator for injecting a drug into an animal body comprising a bladder adapted to be implanted in the body having self-sealing means for permitting a drug to be injected into the interior of said bladder and a pump adapted to be implanted in the body for pumping the drug from said bladder, said pump having an inlet connected to said bladder and an outlet adapted to be positioned within said body.
2. An implantable drug administrator according to claim 1 wherein said self-sealing means comprises a port.
3. An implantable drug administrator according to claim 2 wherein said port includes a protruding ring.
4. An implantable drug administrator according to claim 2 including a striker plate bonded to said bladder in the area beneath said port.
5. An implantable drug administrator according to claim 2 wherein said port includes a magnetically permeable material.
6. An implantable drug administrator according to claim 1 including means connected to said pump for indicating the rate at which said pump is operating.
7. An implantable drug administrator according to claim 6 including means for testing the operation of said indicator means.
8. An implantable drug administrator according to claim 6 wherein said indicating means includes a coil for producing a current in response to a field exterior of said body.
9. An implantable drug administrator according to claim 8 wherein said pump is adapted to be operated by a magnetic field and said coil is wound around said pump to intersect said magnetic field.
- 10. An implantable drug administrator according to claim 8 wherein said indicating means includes a light source connected in circuit with said coil.
11. An implantable drug administrator according to claim 10 including a switch connected in circuit with said coil and said light source, said switch being adapted to be activated in response to the operation of said pump.
12. An implantable drug administrator according to claim 11 wherein said pump includes a rotor, and said switch is adapted to be activated by said rotor.
13. An implantable drug administrator according to claim 12 wherein said pump includes an outer casing and said switch is mounted within said casing.
14. An implantable drug administrator according to claim
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3604417 *||Mar 31, 1970||Sep 14, 1971||American Cyanamid Co||Osmotic fluid reservoir for osmotically activated long-term continuous injector device|
|US3640269 *||Oct 24, 1969||Feb 8, 1972||Delgado Jose M R||Fluid-conducting instrument insertable in living organisms|
|US3692027 *||Apr 23, 1971||Sep 19, 1972||Ellinwood Everett H Jr||Implanted medication dispensing device and method|
|US3730186 *||Mar 5, 1971||May 1, 1973||Univ Calif||Adjustable implantable artery-constricting device|
|US3731669 *||Oct 16, 1970||May 8, 1973||Sander Nuclear Corp||External implantation of energy to power internal devices|
|US3731681 *||Jan 14, 1972||May 8, 1973||Univ Minnesota||Implantable indusion pump|
|US3750194 *||Mar 16, 1971||Aug 7, 1973||Fairchild Industries||Apparatus and method for reversibly closing a natural or implanted body passage|
|US3757846 *||Apr 12, 1971||Sep 11, 1973||Herman H||Method and apparatus for effecting electromagnetic displacement of fluids|
|US3765414 *||Mar 10, 1972||Oct 16, 1973||Hydro Med Sciences Inc||Drug release system|
|US3783868 *||May 6, 1971||Jan 8, 1974||Gulf Oil Corp||Percutaneous implant|
|US3796217 *||May 17, 1973||Mar 12, 1974||Hydr Med Sciences Inc||Drug release system|
|US3831583 *||Feb 5, 1973||Aug 27, 1974||Univ Calif||Implantable bulb for inflation of surgical implements|
|US3923060 *||Apr 23, 1974||Dec 2, 1975||Jr Everett H Ellinwood||Apparatus and method for implanted self-powered medication dispensing having timing and evaluator means|
|US3971376 *||Oct 2, 1974||Jul 27, 1976||Ceskoslovenska Akademie Ved||Method and apparatus for introducing fluids into the body|
|US3996933 *||Oct 4, 1975||Dec 14, 1976||Morton Gutnick||Intrauterine contraceptive devices and processes|
|US4013074 *||Apr 6, 1976||Mar 22, 1977||Siposs George G||Implantable medication-dispensing device|
|US4041954 *||May 7, 1975||Aug 16, 1977||Kabushiki Kaisha Daini Seikosha||System for detecting information in an artificial cardiac pacemaker|
|US4102998 *||Jul 1, 1976||Jul 25, 1978||Morton Gutnick||Process for the prevention of venereal disease|
|US4133302 *||Apr 29, 1977||Jan 9, 1979||The Commonwealth Industrial Gases Limited||Infant incubator|
|US4146029 *||May 31, 1977||Mar 27, 1979||Ellinwood Jr Everett H||Self-powered implanted programmable medication system and method|
|US4152098 *||Jan 3, 1977||May 1, 1979||Clark Ivan P||Micropump|
|US4221219 *||Jul 31, 1978||Sep 9, 1980||Metal Bellows Corporation||Implantable infusion apparatus and method|
|US4253201 *||May 24, 1979||Mar 3, 1981||Ross David A||Prosthesis with self-sealing valve|
|US4265241 *||Feb 28, 1979||May 5, 1981||Andros Incorporated||Implantable infusion device|
|US4445826 *||Jan 22, 1982||May 1, 1984||Polaroid Corporation||Peristaltic pump apparatus|
|US4604090 *||Nov 22, 1983||Aug 5, 1986||Consolidated Controls Corporation||Compact implantable medication infusion device|
|US4615691 *||Dec 8, 1983||Oct 7, 1986||Salomon Hakim||Surgically-implantable stepping motor|
|US4677982 *||Mar 29, 1984||Jul 7, 1987||New York University||Infrared transcutaneous communicator and method of using same|
|US4687468 *||Jul 25, 1986||Aug 18, 1987||Cook, Incorporated||Implantable insulin administration device|
|US4692147 *||Jul 19, 1985||Sep 8, 1987||Medtronic, Inc.||Drug administration device|
|US4710177 *||May 15, 1986||Dec 1, 1987||Smith Robert R||Subcutaneous ventricular injection apparatus and method|
|US4747832 *||May 16, 1986||May 31, 1988||Jacques Buffet||Device for the injection of fluid, suitable for implantation|
|US4772257 *||Oct 7, 1986||Sep 20, 1988||Salomon Hakim||External programmer for magnetically-adjustable cerebrospinal fluid shunt valve|
|US4816016 *||Mar 18, 1988||Mar 28, 1989||Pudenz-Schulte Medical Research Corp.||Subcutaneous infusion reservoir and pump system|
|US4820273 *||Mar 1, 1988||Apr 11, 1989||Eaton Corporation||Implantable medication infusion device and bolus generator therefor|
|US4840190 *||Apr 14, 1988||Jun 20, 1989||Dow Corning Wright||Lozenge-shaped low profile injection reservoir|
|US4884013 *||Jan 15, 1988||Nov 28, 1989||Sherwood Medical Company||Motor unit for a fluid pump and method of operation|
|US5061243 *||Feb 8, 1989||Oct 29, 1991||Baxter International Inc.||System and apparatus for the patient-controlled delivery of a beneficial agent, and set therefor|
|US5085644 *||May 20, 1991||Feb 4, 1992||Pudenz-Schulte Medical Research Corporation||Sterilizable medication infusion device with dose recharge restriction|
|US5152753 *||Apr 2, 1990||Oct 6, 1992||Pudenz-Schulte Medical Research Corporation||Medication infusion device with dose recharge restriction|
|US5762599 *||May 2, 1994||Jun 9, 1998||Influence Medical Technologies, Ltd.||Magnetically-coupled implantable medical devices|
|US6458118 *||Feb 23, 2000||Oct 1, 2002||Medtronic, Inc.||Drug delivery through microencapsulation|
|US6485462||Aug 24, 2000||Nov 26, 2002||Science Incorporated||Fluid delivery device with heat activated energy source|
|US6582418||Jun 1, 2000||Jun 24, 2003||Medtronic, Inc.||Drug pump with reinforcing grooves|
|US6592571||May 24, 2000||Jul 15, 2003||Medtronic, Inc.||Drug pump with suture loops flush to outer surface|
|US6719739||Aug 27, 2001||Apr 13, 2004||Medtronic, Inc.||System and method for attaching upper and lower outer cases in an implantable drug pump|
|US6986751||Oct 31, 2003||Jan 17, 2006||Cabg Medical, Inc.||Grafted network incorporating a multiple channel fluid flow connector|
|US6991615||Aug 2, 2004||Jan 31, 2006||Cabg Medical, Inc.||Grafted network incorporating a multiple channel fluid flow connector|
|US7011643||Aug 5, 2003||Mar 14, 2006||Cabg Medical, Inc.||Grafted network incorporating a multiple channel fluid flow connector|
|US7341577||Apr 30, 2003||Mar 11, 2008||Renishaw Plc||Implantable drug delivery pump|
|US7361168||Aug 4, 2004||Apr 22, 2008||Acclarent, Inc.||Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders|
|US7410480||Sep 23, 2005||Aug 12, 2008||Acclarent, Inc.||Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders|
|US7419497||Oct 4, 2006||Sep 2, 2008||Acclarent, Inc.||Methods for treating ethmoid disease|
|US7547323||Aug 29, 2006||Jun 16, 2009||Sinexus, Inc.||Stent for irrigation and delivery of medication|
|US7720521||Apr 26, 2005||May 18, 2010||Acclarent, Inc.||Methods and devices for performing procedures within the ear, nose, throat and paranasal sinuses|
|US7785315||Aug 31, 2010||Acclarent, Inc.||Methods for irrigation of ethmoid air cells and treatment of ethmoid disease|
|US7862502||Jun 8, 2007||Jan 4, 2011||Ellipse Technologies, Inc.||Method and apparatus for adjusting a gastrointestinal restriction device|
|US7967806||Jun 28, 2011||Medtronic, Inc.||Method of delivering a fluid medication to a patient in flex mode|
|US7967812||Jun 28, 2011||Medtronic, Inc.||Drug infusion system programmable in flex mode|
|US7981025||Jul 19, 2011||Ellipse Technologies, Inc.||Adjustable implant and method of use|
|US8080000||Dec 20, 2011||Acclarent, Inc.||Methods and apparatus for treating disorders of the ear nose and throat|
|US8088101||Oct 26, 2007||Jan 3, 2012||Acclarent, Inc.||Devices, systems and methods for treating disorders of the ear, nose and throat|
|US8090433||Jan 3, 2012||Acclarent, Inc.||Methods and apparatus for treating disorders of the ear nose and throat|
|US8100933||May 8, 2008||Jan 24, 2012||Acclarent, Inc.||Method for treating obstructed paranasal frontal sinuses|
|US8114062||Oct 1, 2009||Feb 14, 2012||Acclarent, Inc.||Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders|
|US8114113||Oct 4, 2005||Feb 14, 2012||Acclarent, Inc.||Multi-conduit balloon catheter|
|US8118757||Apr 30, 2007||Feb 21, 2012||Acclarent, Inc.||Methods and devices for ostium measurement|
|US8123722||Oct 29, 2007||Feb 28, 2012||Acclarent, Inc.||Devices, systems and methods for treating disorders of the ear, nose and throat|
|US8142422||Mar 27, 2012||Acclarent, Inc.||Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat|
|US8146400||Jul 31, 2007||Apr 3, 2012||Acclarent, Inc.||Endoscopic methods and devices for transnasal procedures|
|US8172828||May 8, 2012||Acclarent, Inc.||Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures|
|US8182432||May 22, 2012||Acclarent, Inc.||Corewire design and construction for medical devices|
|US8190389||May 17, 2006||May 29, 2012||Acclarent, Inc.||Adapter for attaching electromagnetic image guidance components to a medical device|
|US8246533||Aug 21, 2012||Ellipse Technologies, Inc.||Implant system with resonant-driven actuator|
|US8277503||Oct 2, 2012||Intersect Ent, Inc.||Stent for irrigation and delivery of medication|
|US8277504||May 7, 2009||Oct 2, 2012||Intersect Ent, Inc.||Stent for irrigation and delivery of medication|
|US8317816||Nov 27, 2012||Acclarent, Inc.||Balloon catheters and methods for treating paranasal sinuses|
|US8388642||Aug 29, 2008||Mar 5, 2013||Acclarent, Inc.||Implantable devices and methods for treating sinusitis and other disorders|
|US8414473||Apr 9, 2013||Acclarent, Inc.||Methods and apparatus for treating disorders of the ear nose and throat|
|US8425457||Dec 29, 2009||Apr 23, 2013||Acclarent, Inc.||Devices, systems and methods for diagnosing and treating sinusitus and other disorder of the ears, nose and/or throat|
|US8435290||Mar 24, 2010||May 7, 2013||Acclarent, Inc.||System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx|
|US8439687||May 14, 2013||Acclarent, Inc.||Apparatus and method for simulated insertion and positioning of guidewares and other interventional devices|
|US8480655||Jun 21, 2011||Jul 9, 2013||Medtronic, Inc.||Drug infusion system programmable in flex mode|
|US8485199||May 8, 2007||Jul 16, 2013||Acclarent, Inc.||Methods and devices for protecting nasal turbinate during surgery|
|US8545255 *||Apr 23, 2010||Oct 1, 2013||Centre Hospitalier Universitaire De Rouen||Subcutaneous device for electrical percutaneous connection|
|US8639353||Apr 23, 2010||Jan 28, 2014||Centre Hospitalier Universitaire De Rouen||Electrical connection device implantable in the human body|
|US8702626||Dec 29, 2006||Apr 22, 2014||Acclarent, Inc.||Guidewires for performing image guided procedures|
|US8715159||Jun 10, 2011||May 6, 2014||Ellipse Technologies, Inc.||Adjustable implant and method of use|
|US8715169||Oct 30, 2007||May 6, 2014||Acclarent, Inc.||Devices, systems and methods useable for treating sinusitis|
|US8721591||Jan 23, 2012||May 13, 2014||Acclarent, Inc.||Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures|
|US8740929||Feb 6, 2002||Jun 3, 2014||Acclarent, Inc.||Spacing device for releasing active substances in the paranasal sinus|
|US8747389||Apr 24, 2007||Jun 10, 2014||Acclarent, Inc.||Systems for treating disorders of the ear, nose and throat|
|US8764709||Jun 30, 2010||Jul 1, 2014||Acclarent, Inc.||Devices, systems and methods for treating disorders of the ear, nose and throat|
|US8764726||Aug 18, 2009||Jul 1, 2014||Acclarent, Inc.||Devices, systems and methods useable for treating sinusitis|
|US8764729||Dec 22, 2008||Jul 1, 2014||Acclarent, Inc.||Frontal sinus spacer|
|US8764786||Oct 9, 2012||Jul 1, 2014||Acclarent, Inc.||Balloon catheters and methods for treating paranasal sinuses|
|US8777926||Mar 15, 2013||Jul 15, 2014||Acclarent, Inc.||Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasel or paranasal structures|
|US8808163||Oct 11, 2012||Aug 19, 2014||Ellipse Technologies, Inc.||Adjustable implant and method of use|
|US8828041||Mar 18, 2010||Sep 9, 2014||Acclarent, Inc.||Devices, systems and methods useable for treating sinusitis|
|US8852143||Apr 7, 2010||Oct 7, 2014||Acclarent, Inc.||Devices, systems and methods for treating disorders of the ear, nose and throat|
|US8858586||Jan 18, 2007||Oct 14, 2014||Acclarent, Inc.||Methods for enlarging ostia of paranasal sinuses|
|US8864787||Apr 9, 2008||Oct 21, 2014||Acclarent, Inc.||Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis|
|US8870893||Apr 29, 2010||Oct 28, 2014||Acclarent, Inc.||Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat|
|US8894614||Feb 16, 2006||Nov 25, 2014||Acclarent, Inc.||Devices, systems and methods useable for treating frontal sinusitis|
|US8905922||Mar 26, 2012||Dec 9, 2014||Acclarent, Inc.||Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat|
|US8932276||May 16, 2007||Jan 13, 2015||Acclarent, Inc.||Shapeable guide catheters and related methods|
|US8945088||Apr 28, 2010||Feb 3, 2015||Acclarent, Inc.||Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures|
|US8951225||May 18, 2006||Feb 10, 2015||Acclarent, Inc.||Catheters with non-removable guide members useable for treatment of sinusitis|
|US8961398||Oct 31, 2007||Feb 24, 2015||Acclarent, Inc.||Methods and apparatus for treating disorders of the ear, nose and throat|
|US8961495||Oct 29, 2007||Feb 24, 2015||Acclarent, Inc.||Devices, systems and methods for treating disorders of the ear, nose and throat|
|US8968269||Jan 18, 2012||Mar 3, 2015||Acclarent, Inc.||Multi-conduit balloon catheter|
|US8979888||Jul 30, 2009||Mar 17, 2015||Acclarent, Inc.||Paranasal ostium finder devices and methods|
|US9039657||Sep 3, 2009||May 26, 2015||Acclarent, Inc.||Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders|
|US9039680||Apr 21, 2008||May 26, 2015||Acclarent, Inc.||Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders|
|US9050440||Sep 22, 2006||Jun 9, 2015||Acclarent, Inc.||Multi-conduit balloon catheter|
|US9055965||Mar 22, 2010||Jun 16, 2015||Acclarent, Inc.||Devices, systems and methods useable for treating sinusitis|
|US9072626||May 6, 2013||Jul 7, 2015||Acclarent, Inc.||System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx|
|US9084876||Mar 15, 2013||Jul 21, 2015||Acclarent, Inc.||Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders|
|US9089258||Mar 15, 2007||Jul 28, 2015||Acclarent, Inc.||Endoscopic methods and devices for transnasal procedures|
|US9101384||Jan 16, 2009||Aug 11, 2015||Acclarent, Inc.||Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat|
|US9107574||Dec 8, 2011||Aug 18, 2015||Acclarent, Inc.||Endoscopic methods and devices for transnasal procedures|
|US9155492||Sep 24, 2010||Oct 13, 2015||Acclarent, Inc.||Sinus illumination lightwire device|
|US9167961||Oct 31, 2007||Oct 27, 2015||Acclarent, Inc.||Methods and apparatus for treating disorders of the ear nose and throat|
|US9179823||Jun 5, 2009||Nov 10, 2015||Acclarent, Inc.||Methods and devices for facilitating visualization in a surgical environment|
|US9198736||Apr 19, 2012||Dec 1, 2015||Acclarent, Inc.||Adapter for attaching electromagnetic image guidance components to a medical device|
|US9220879||Apr 30, 2014||Dec 29, 2015||Acclarent, Inc.||Devices, systems and methods useable for treating sinusitis|
|US9241834||Mar 21, 2014||Jan 26, 2016||Acclarent, Inc.||Devices, systems and methods for treating disorders of the ear, nose and throat|
|US9265407||Jul 31, 2007||Feb 23, 2016||Acclarent, Inc.||Endoscopic methods and devices for transnasal procedures|
|US9271857||Mar 25, 2015||Mar 1, 2016||Ellipse Technologies, Inc.||Adjustable implant and method of use|
|US9289584||Sep 13, 2011||Mar 22, 2016||The University Of British Columbia||Remotely controlled drug delivery systems|
|US9308361||Mar 4, 2013||Apr 12, 2016||Acclarent, Inc.||Implantable devices and methods for treating sinusitis and other disorders|
|US9339636||Sep 5, 2013||May 17, 2016||Mubashir H Khan||Subcutaneous fluid pump|
|US20030216714 *||Apr 30, 2003||Nov 20, 2003||Gill Steven Streatfield||Pump|
|US20040077996 *||Oct 22, 2002||Apr 22, 2004||Jasperson Keith E.||Drug infusion system with multiple medications|
|US20040077997 *||Oct 22, 2002||Apr 22, 2004||Jasperson Keith E.||Drug infusion system programmable in flex mode|
|US20040181204 *||Mar 25, 2004||Sep 16, 2004||Jasperson Keith E.||Method of delivering a fluid medication to a patient in flex mode|
|US20040228411 *||Sep 16, 2003||Nov 18, 2004||Sony Corporation||Method and system for decoder clock control in presence of jitter|
|US20040230182 *||Dec 23, 2003||Nov 18, 2004||Medtronic, Inc.||Drug delivery through encapsulation|
|US20050033218 *||Oct 31, 2003||Feb 10, 2005||Villafana Manuel A.||Grafted network incorporating a multiple channel fluid flow connector|
|US20050033219 *||Aug 2, 2004||Feb 10, 2005||Villafana Manuel A.||Grafted network incorporating a multiple channel fluid flow connector|
|US20060106361 *||Sep 23, 2005||May 18, 2006||Acclarent, Inc.||Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders|
|US20070073230 *||Nov 16, 2006||Mar 29, 2007||Medtronic, Inc.||Drug infusions system with multiple medications|
|US20070083153 *||Sep 28, 2006||Apr 12, 2007||Hans-Peter Haar||Infusion system for administration of a liquid medication|
|US20080097354 *||Aug 29, 2006||Apr 24, 2008||Francois Lavigne||Stent for irrigation and delivery of medication|
|US20080304710 *||Jun 8, 2007||Dec 11, 2008||Lijie Xu||Method and apparatus for processing image of at least one seedling|
|US20090275882 *||Nov 5, 2009||Francois Lavigne||Stent for irrigation and delivery of medication|
|US20090275903 *||May 7, 2009||Nov 5, 2009||Francois Lavigne||Stent for irrigation and delivery of medication|
|US20100198247 *||Aug 5, 2010||Acclarent, Inc.||Devices, Systems and Methods for Treating Disorders of the Ear, Nose and Throat|
|US20110237861 *||Sep 29, 2011||Ellipse Technologies, Inc.||Adjustable implant and method of use|
|US20120045918 *||Apr 23, 2010||Feb 23, 2012||Pierre-Yves Litzler||Subcutaneous device for electrical percutaneous connection|
|EP0140727A1 *||Aug 14, 1984||May 8, 1985||Jacques Buffet||Implantable fluid injection device|
|EP0392566A1 *||Sep 24, 1985||Oct 17, 1990||Cook Incorporated||Implantable insulin administration device|
|EP1772162A1 *||Oct 8, 2005||Apr 11, 2007||Boehringer Mannheim Gmbh||Infusion system for delivery of a liquid drug|
|EP2288406A2 *||Jun 22, 2009||Mar 2, 2011||Yehoshua Shachar||A magnetic breather pump and a method for treating a brain tumor using the same|
|EP2288406A4 *||Jun 22, 2009||Nov 20, 2013||Yehoshua Shachar||A magnetic breather pump and a method for treating a brain tumor using the same|
|WO1980001755A1 *||Feb 25, 1980||Sep 4, 1980||Andros Inc||Implantable infusion device|
|WO2002017989A2||Aug 29, 2001||Mar 7, 2002||Medtronic, Inc.||System and method for attaching upper and lower outer cases in an implantable drug pump|
|International Classification||A61M5/142, F04B43/12|
|Cooperative Classification||A61M5/14276, A61M2205/3515, F04B43/1238|
|European Classification||F04B43/12F, A61M5/142P10|