|Publication number||US3545439 A|
|Publication date||Dec 8, 1970|
|Filing date||Jan 4, 1968|
|Priority date||Jan 4, 1968|
|Also published as||CA985173A, CA985173A1, DE1900196A1|
|Publication number||US 3545439 A, US 3545439A, US-A-3545439, US3545439 A, US3545439A|
|Inventors||Duncan Gordon W|
|Original Assignee||Upjohn Co|
|Export Citation||BiBTeX, EndNote, RefMan|
|Referenced by (136), Classifications (24)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States atent  Inventor Gordon W. Duncan 2,423,475 7/1947 Rice et a1 424/28 Kalamazoo, Michigan 3,442,266 5/1969 Krejciet a1. 128/130 ] App]. No. 696,011 3,055,297 9/1962 Leeds...... 424/28  Wed 2 Primary Exuminer- Adele M. Eager  Pau :med Attorneys-Joseph K. Andonian, John Kekich and Edward G.  Assignee The Up ohn Company Jones Kalamazoo, Michigan a corporation of Delaware  MEDICATED DEVICES AND METHODS 19 clalms4nrawmg Flgs' ABSTRACT: An improved resilient annular device for in-  US. Cl 128/260, travaginal placement and retention as required and formed of 3/ 128/130 128/270 260/75 a compatible nonabsorbable polymeric substance such as an  Int. Cl A6lm 7/00 organopolysiloxane nylon, natural or Synthetic rubber,  Field of Search 128/130, dacron, teflon, polyurethane and polyethylene and containing 131, 128, 129,334, 270, 156, 268, 260, 1; 24/ an effective amount of a medicament which is capable of 27, 28; 264/337; 260/75, 858; 3/ passage through the drug-permeable polymeric material. The References Cited device is useful to provide a readily inserted, readily retained and readily removable source of continued medication for UNITED STATES PATENTS sustained beneficial effects in female mammals, human and 2,017,596 1/1936 Hoffman 424/28 animal.
. MEDICATED DEYICES ANDMETHODS BRIEF SUMMARY OF THE INVENTION This invention relates to pharmaceutical devices and methods of their use, more particularly to sucha device for intravaginal placement in the form of a resilient medicated ring comprised of acompatible nonabsorable polymeric material and an effective amount of a diffusible medicament. The invention relates also to methods of providing continuous medication, during a predetermined medication period via the vagina in female mammals, human and animal, for example dogs, sheep, cattle, horses, and rats.
BRIEF DESCRIPTION OF THE DRAWING DETAILED DESCRIPTION It has beenfound thatt he device according to this invention provides sufiiciently resilient characteristics so that upon tensing for ready manual or mechanical insertion in the vaginal tract there will be relative ease of handling. Upon 'releaseof tension, the device will resume the annular form necessary for providing retentive contact within the vaginal area. Proper retention is obtained upon placement in the vaginain accordance with FIG. 3 and when properly placed, the ring fits securely and comfortably between the rear wall of the vagina and the upper edge, of the pubic bone. In that position the medicated device can'be readily inserted and is readily retained during the desired period of continued medication. when it is desired that medication cease, the ring is readily removed in a reverse fashion to insertion.
'As aforesaid, "the resilient annular device is formed of a compatible drug-permeable polymeric materiall As used herein, the word compatible means compatible both with the environment of the vaginal tract in that there is no break-' down of the annular tensile nature of the device due to the contents of the vagina, nor isthere any absorption of the polymeric material itself, only the medication being absorbed ing to known methods from polyisocyanate and polyhydroxyl material. The .polyhydroxyl materials, for example polyesters, polyethers and the like, are reacted with isocyanates to yield rubberlike products for use as millalble gums or in casting systems or as thermo processable res-ins. See U.S. Pat. Nos. 2,87 1,218 and 3,015,650. Another exemplary polymer is polyethylene, prepared by polymerization of ethylene, usually prepared from natural gas or the cracking of crude oil. Modern Plastics Encyclopedia for 1968, Sept, 1967, Vol. 45, No. la,"Mc,Graw-Hill, New York, New York, U.S.A. describes the preparation of the aforesaid suitable plastic materials, especially in reference to their molding qualities, compression molding temperatures, and'compression molding pressures. Details on theaforesaid polymers are given in the plastic properties chart of the aforesaid Encyclopedia, pages 29 through 46, inclusive. In rcference-to'the nonabsorbability and nontoxic nature of the aforesaid polymeric material, U.S. Pat. No. 3,272,204 refers to the use of vinyon N, nylon, orlon, dacron, teflon, and the like as nonabsorbable, reinforcing strands for the preparation ofprostheses'. Such strands have the advantage that they do not become a pant of the body tissues. So it is with the improyed resilient annular device of the present invention, which is particularly advantageous because of its ready insertion and ready retentionbut does not become or form any part of the tissue of the female'mammal utilizing the device, for example human and animal, such as dogs, cattle,
and horses. In this respect, the present annular device, with its medication contained therein for continued medication as desired, is greatly superior to implantates, which of necessity are placed within the actual'body tissues, such placement often requiring at least minor surgery for both insertion and removal, especially if encapsulated- As aforesaid, the device, properly sizedand fitted, is useful to provide a readily inserted, readily retained, and readily removable source of continued medication for local and systemic effects Subject to the-property of being capable of passage through the polymeric material, a wide range of medication is suitable for use in this improved device for both local and systemic effects. Suitable drugs are triiodothyronine, isoproterenol, atropine, histamine, nitrogen mustard, vitamin B pyrimethamine, hormonal substances,
i.e., estrogenic substances, progestational substances, an-
drogenic substances, e.g., estradiol, progesterone, androstenedione, testosterone, cortisol, medroxyprogesterone acetate, melengestrol acetate, chlormadinone, and the like. In
forv local and systemic effects in the female mammals.
Likewise, there is nodeleterious action on the sensitive tissue in the area of placement in the vaginal tract. Widely varying types of polymeric material are suitable in providing these compatible, nontoxic and nonabsorbable properties, for exampleorganopolysiloxane of the linear type converted to rubber by heat curing (vulcanization). These linear organopolysiloxanes are known as the conventional type, for example dimethyloplysiloxane, Likewise suitable are those known as the RTV type which are converted to the rubbery stateat room temperature in the presence of a catalyst. U.S.
Pat. No. 3,279,996 describes various conventional silicone rubbers which may or may not contain fillers,sujch assilica, .to
enhance tensile strength and the other physical properties of the cured rubber. This patent also describes commercially available'RTV'silicone rubbers. Other patent literature shows the preparation of conventional silicone rubbers, illustratively U.S. ,Pats. Warwick, No. 2,504,137; Konkle et al., No. 2,890,188; andotherpatents set, forth, in the U.S. Pat. to Long et al., No. 3,279,966. Other suitable nontoxic, nonabsorbable,
compatible, drug-permeable polymeric materials, are, for example, nylon, a polyamide'resin made by polymerization of the hexamethylenediamine salt of adipic acidydacron, a synthetic fiber made by E. I. DuPont deNer'nours and Co.
this connection, both in vivo and invitro methods of determination of passage of the drug by diffusion through the drugpermeable polymeric material are available. See Dziuk, P. J. r and Cook,- B., Passage of Steroids Through Silicone Rubbers, Endocrinology, 78:208, 1966; U.S. Pat. No. 3,279,996; Folkman and Edmonds, Circulation Research 102632, 1962; Folkman and Long, J. Surg. Res. 43:139, 1964; Powers, 1. Parasitology51:53 (April 1965), No. 2 Section 2. An in vitro method of test utilizes polymeric material, e.g., polysiloxane tubing which is loaded with the particular drug and plugged at the ends with polysiloxane cement. After allowing about 48 hours for setting or curing, the filled linlr of tubing is placed in, for example, 50 mlof normal saline in a suitable container and shaken at approximately body temperature for about 24 hours. Spectroscopic analysis of the liquid, for example by the isonicotinic hydrazide method for medroxyprogesterone acetate, shows that the drug is capable of permeating through the silastic into the saline material, in which it can be demonstrated by the in vitro test. For in vivo testing, placement of a suitable size device containing a known amount of medicaments, e.g., rnedroxyprogesterone acetate in a polysiloxane,
of medication in each of the annular devices is that sufficient from teraphthalic acid; and ethylene glycol; teflon, a
tetrafluoroethylene polymer manufactured by E. l. DuPont de Nemoursand Co.; polyurethane elastomer prepared accordfor bringing about the desired physiologic effect, for example, the amount sufficient for controlling fertility. Given in ranges of active ingredients, suitable amounts for individual drugs in digitoxin,
the device are as follows: digitoxin, 5 to 50 mg.; triiodothyronine, l to 10 mg.; isoproterenol, lOO mg. to 2 6m; atropine, 10 to 250 mg.; histamine, 1 to 10 mg.; nitrogen mustard, 50 mg. to 2 Gm.; vitamin B 0.5 to 100 mg; pyrimethamine, 50 mg. to l Gm.; estradiol, 0.5 to 100 mg.; progesterone, 50 mg. to 2 Gm.; androstenedione, 50 mg. to 2 6m; testosterone, 50 mg. to 2 Gm.; cortisol, 100 mg. to 2.5 Gm.; medroxyprogesterone acetate, 50 mg. to 2 Gm.; melengestrol acetate, 50 mg. to 2 Gm.; chlormadinone, 50 mg. to 2 Gm. The amount of any additive medication, for example locally effective antimicrobial agent, is calculated on the basis of the known amounts useful in similar vaginal applications. Other principal active medicaments are, for example, antiulcer and antisecret ory agents, for example 'methscopolamine, 75mg. to 2 Gm.; anticoagulant, for example diphenadione, 75 mg. to l Gm; hypocholesteremic agent, for example 3methyl-5-isoxazole carboxylic acid, 200 mg. to 2 Gm.; appetite clepressant, for example D-amphetamine, l mg. to 2 Gml; tranquilizers and sedatives, thiothixene and haloperidol, 50 mg. to 2 6m; hypoglycemic agent, l[[p-[2- (S-chloro-wanisamidokthyl]phenyl]sulfonyl]-3-cyclohexylurea, 100mg. to 2.5 Gm.; hypotensive agent, mecamylamine, 100 mg. to 1.5 Gm; antibacterial and antimalarial agents, 7- deoxy-7(S)-chlorolincomycin, 2 to 7 0m, N-demethyl lincomycin, 2- to .7-Gm., 4 pentyl-N-'demethyl-7(S)-chlorolincomycin, l to 5.Gm.; antihypertensive agent, for example angiotensin amide, 100 mg. to 2 Gm.; glucocorticoid, for example dexamethasone, 10 to 250 mg.: prostaglandins, for example PGE,, PGE PGA, as antiulcer and antisecretory agents and for inhibition of blood platelet stickiness, 0.5 to 10 mg. The aforesaid amounts are ranges of active ingredients tobe included in the annular device, the exact amount depending upon the age, condition of the patient, and the particular effect desired. These amounts are calculated to provide predetermined daily release dosages as follows: for the cardiac stimulant digitoxin, 0.1 to 0.2 mg.; for the metabolic stimulant triiodothyronine, to 100 mcg.; for the bronchodilator isoproterenol, 5 to 30 mg.; for the antianemia agent vitamin B12, to 300 mcg.; for the antimalarial pyrimethamine, l to 5 mg.;' for the estrogen estradiol, 1 to 500 mcg.; for the progestogen progesterone, 0.1 to 20 mg; for the androgens androstenedione and testosterone, 0.1 to 10 mg.; for the glucocorticoid cortisol, 5 to 50 mg.; for the progestogens medroxyprogesterone acetate, melengestrol acetate, and chlormadinone, 0.01 to 10 mg.; for the methscopolamine, 3 to 20 mg.; for the diphenadione, 3 to 5 mg.; for the 3-methyl-5- isoxazole carboxylic acid, l0 to 30 mg.; for rl-amphetamine, 5 to 30 mg.; for thiothixene, 2 to 30 mg.; for haloperidol, 2 to mg.; for the hypoglycemic cyclohexylurea compound, 5 to 50 mg.; for the mecamylamine, 2 to 10 mg.; for the antibacterial,
antimalarial lincomycin compounds, 250 to 500 mg., 250 to 500 mg. and 125 to 300 mg., respectively; for the angiotensin amide, 0.7 to 30 mg.; for the dexamethasone, 0.2 to 2 mg.; and for the prostaglandins, 1 to 10 mcg.
Especially beneficial progestational substances for use in this invention include, for example, norethynodrel, norethindrone, medroxyprogesterone acetate, chlormadinone acetate,
dimethisterone, and ,ethynodiol diacetate. Useful estrogenic substances for combination with these progestogens include,
for example, ethinyl estradiol and 3-methyl ether of ethinyl esthe reproductive tract, for example synivaginitis, endometriosis. These devices are constructed in such a way that they are retained in the vagina for periods of a day up to several months and can be readily inserted and removed, for example in the case of the human female patient. The device, due to its unique shape and size, does not obstruct the os uteri as do diaphragms. The medication for release as desired can be introduced into hollow cavities in the ring forming a tubular device, or directly introduced into the plastic material itself while the device is being manufactured as by molding. The drug can be the individual drugor mixed with suitable compatible physiologic material, for example in the case of a progestogen an estrogen can be included. Likewise, a locally effective antimicrobial agent, for example an antibiotic such as neomycin, nystatin and polymyxin can be included within the polymeric material. The improved device of this invention possesses numerous advantages over, for example the intrauterine devices, which the uterus rejects in some cases. Moreover, nonprofessional placement of the present inventive device is possible in comparison with the intrauterine devices. Unexpected advantages for the improved device as such are ease of placement, ease of retention, ease of removal, relative freedom of infectious conditions, and ease of dosage over a wide range. As aforesaid, the amount of drug incorporated into the inventive device is that sufficient to bring about the local and/or systemic effect, for examplean effective amount for control of fertility, probably by inhibition of ovulation. The medicated device of the present invention provides more uniform and constant serum levels of drug during the predetermined period of time for which the beneficial physiologic effects are desired. This-is in marked contrast to fluctuations that occur with other treatments, for example oral treatment. In thepractice of this invention, low circulating levels ofmedicament can still be highly effective in target tissues while not accumulating in the nontarget tissues. For example in the case of estradiol, the uterine tissue is the target in contrastto the heart, muscle, liver and like tissues, which are non'target tissues.
Depending upon the anatomy of the particular species. involved, the improved ring device will vary in size, for example in the case of the human from about mm. diameter to about mm. diameter, these dimensions being overall dimensions; the diameter of the actual ring itself will be in the neighborhood of about 5 to 10 mm. In the case where an endless helical spring or flat spring structure is used for additional tensing property, the diameter of this metallic part of the ring will vary with that of the device itself. Overall dimensions of the improved medicated ring for use in other species are approximately as follows: for sheep and swine, 20 to 65 mm.; for dogs, 5 to 50 mm.; for cats, 5 to 30 mm.; for cattle, 50 to mm.; and for horses, 50 to mm. These dimensions are overall dimensions. As will be apparent, the actual diameter of the ring itself varies with the overall size and with the particular species. Suitably the annular devices may incorporate a tab for assistance in removal. The polymeric materials are, as disclosed in the aforesaid Modern Plastics Encyclopedia, those that are suitable for molding in manners known to those familiar with this art. Those polymeric materials, for instance the organopolysiloxanes, which are in a liquid state or paste state, can be directly mixed with the drug, for example melengestrol acetate or medroxyprogesterone acetate, and the semifluid material placed into the mold for compression molding with the addition of a catalyst, for example stannous octoate. In case the device is to contain a spring structure for tension properties, this is usually centered in the semifluid material while it is in the mold and thereafter covered by additional drug-containing polymeric material for the compression molding.
An additional, in vivo, technique for determining the suitability of the polymeric material for use in the preparation of the inventive device is as follows: 150 mg. of medr'oxyprogesterone acetate was well mixed with 615 mg. of polysil oxane elastomer 3H2 382 (Dow Corning Company) to prepare resilient containers approximately 4 cm. long and 0.48 cm. in diameter. Different dosages of the drug are obtained by cutting the required length of the material. The material is sterilized and can be inserted subcutaneously into the scapular region of normally cycling female rats. Daily records of vaginal cytology, which reflect the release'of the medroxyprogesterone acetate, are made for periods of 2 to 6 weeks at dosages of 18.75 .mg. for 6 weeks in four animals, 37.5 mg. for 2 weeks in four animals, and 56.25 mg. for 2 weeks in four animals. Cycling is prevented in the otherwise normally cycling female rats. This shows that the active medicament is released by diffusion through the drugpermeable polymer and exerts its physiological effect via the vaginal tract. in addition to the in vivo data in the rats, it was found by measuring the final content of the medicament in the silastic material that average total releases of 4.4 mg., 5 mg. and 5.2 mg. occurred from elastomeric carrier material of 0,5, 1.0 and 1.5 cm. in size, respectively.
The following examples illustrate the manner and process of making and using the inventive annular device, but are not to be construed as limiting. i it EXAMPLE 1 An annular device was 'prepared of organopolysiloxane elastomer containing 170 mg. of medroxyprogesterone acetate. The ring was placed in accordance with the technique of this invention in the vaginal tract of a monkey and allowed to remain there for 63 days. At the end of this time, the residual content of the medicament in the ring was found by analysis to be l32 mg., showing that a sufficient amount for control of fertility was released from the ring during its retention within the vaginal tract.
EXAMPLE 2 Resilient devices are prepared, each to contain 2 Gm. of medroxyprogesterone acetate, 3 drops of stannous octoate as catalyst, and q.s. silastic elastomer, medical grade 382 (Dow Corning Company).
12.85 Gm. of medroxyprogesterone.acetate are thoroughly mixed into 92.15 Gm. dimetliylpolysiloxane elastomer, medical grade 382 (Dow Corning Company). 21 Gms. of this mixture plus 3 drops of catalyst, stannous octoate, is incorporated into each mold designed to prepare a device of an outside diameter of about 80 mm. The two halves of the mold are tightened down bythe use of wing nuts and the mold is allowed to cure in an oven of 40 to 50 C. for l to 2 hours. Each so prepared ring weighs about 17 Gm. and contains about 2 Gm. of the medroxyprogesterone acetate. Placement of a ring in the vaginal tract of the human female supplies an effective amount of medroxyprogesterone acetate for the control of fer tility by inhibition of ovulation. Measurement of basal body temperature shows that ovulation did not occur during a 4 week test period.
Eimilar rings are prepared with other molds designed to give outside diameters of 70, and 75 mm., respectively. Although these annular ring structures will cure at room temperature in the presence-of the catalyst, for convenience and speed of handling, they are cured at temperatures of from about 40 to about 70 C.
Tensing means are added to the devices prepared as in Examplez by positioning within the first half of the mold an endless helical spring having a diameter of about 8 mm. and weighing approximately 4.8 Gm. The upper half of the mold is then sealed down with the use of the wing nuts and the device compression molded in a like manner at about 45 C.
EXAMPLE 4 Polyurethane rubber-type annular devices are prepared by polymerizing two equivalents of methylene bis isocyanate, one equivalent of 3,000 molecular weight polyether triol and one isocyanate, 1,000 of the trio] and 45 of the butanediol. At the time of mixing, melengestrol acetate to provide 2 Gm. per individual ring is added to the mixture. The mixture of drug and elastomer is then heat cured in the mold at about 100 for 1 hour to provide resilient annular devices for placing in the vaginal tract.
EXAMPLE 5 Likewise, medicated annular devices containing an effective amount of the drug which can permeate through the polymeric substance are prepared from nylon, natural rubber, synthetic rubber, dacron, teflon, and polyethylene and are useful in the same manner inproviding continued sustained medication over desired predetermined periods of times in the vaginal tract of the female mammals.
The manner and process of making and using the invention is not limited to the aforesaid examples, :for the other desirable medicaments as heretofore listed can be incorporated into devices prepared from the various polymeric substances to provide sustained medication over predetermined periods of time. As aforesaid, depending upon the particular species in which the device is to be used, the size of the device will vary to provide close anatomical contact with the vagina] or like tract of the female mammals. The relationship between the daily amount of medication to provide a beneficial physiologic effect and the amount initially placed in the inventive annular device has been set forth for the individual drugs concerned, and within this concept the amount of drug is varied for the particular polymer, depending upon the permeability rate and the amount required for the physiological effect. Devices so prepared are likewise beneficially effective in providing the desired medication via the vagina.
Although an annular shaped device is preferred because of simplicity in manufacture and ease in fitting, insertion and removal, other shapes which will fit anatomically, will stay in place and still allow for ease of insertion and removal can be used, such asoval or elliptical shapes. The device does not have to be in one plane if a closer anatomical fit is desired.
1. A medicated annular device in the form of a resilient individual ring which releases medication for systemic effects during intravaginal use in a female mammal consisting essentially of a medicament-permeable, compatible, nonabsorba ble, resilient, polymeric substance and a systemically effective amount of a diffusible medicament for providing to a said female mammal sustained systemic medication for a predetermined period of time.
2. The resilient individual ring of claim 1 wherein the polymeric substance is a polysiloxane or polyurethane elastomer.
3. The resilient individual ring of claim 2 wherein the polysiloxane is convertible to a rubbery state by heat curing or by room temperature in the presence of a catalyst.
4. The resilient individual ring of claim 2 wherein the polysiloxane is an organopolysiloxane 5. The resilient individual ring of claim 4 wherein the organopolysiloxane is dimethylpolysiloxane.
6. The resilient individual ring of claim 1 which is a tubular ring.
7. The resilient individual ring of claim 1 which contains tension providing means.
8. The resilient individual ring of claim 1 wherein the diffusible medicament is effective for systemic inhibition of fertility of said female mammal.
9. The resilient individual ring of claim 5 wherein the dimethylpolysiloxane is convertible to a rubbery state at room temperature in the presence of a catalyst and the diffusibie medicament is medroxyprogesterone acetate.
10. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female mammal, which consists essentially of equivalent of I ,d butnnediol. Parts by weight are 250 of the 7 retain-ably positioning within the vaginal tract of a said female 7 mammal for said predetermined period of time a resilient individual ring according to claim 1.
11. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female human, which consists essentially of retainably positioning within the vaginal tract of a said female human for said predetermined period of time a resilient individual ring according to claim 2.
12. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female human, which consists essentially of retainably positioning within the vaginal tract of a said female human for said predetermined period of time a resilient individual ting according to claim 3.
13. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female human, which consists essentially of retainably positioning within the vaginal tract of a said female human for said predetermined-period of time a resilient individual ring according to claim 4.
14. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female human, which consists essentially of retainably positioning within the vaginal tract of a said female human for said predetermined period of time a resilient individual ring according to claim 5.
15. A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female mammal, which consists essentially of retainably positioning within the vaginal tract of a said female mammal for said predetermined period of time a resilient individual ring according to claim 6.
A method of providing a predetermined amount of systemically effective medicament for a predetermined period of time to a female mammal, which consists essentially of retainably positioning within the vaginal tract of. a said female mammal for said predetermined period of time a resilient individual ring according to claim 7. r
17. A method of providing a predetermined amount of systemically effective fertility-inhibiting medicament for a predetermined period of time to a female mammal, which consists essentially of retainably positioning within the vaginal tract of a said female mammal for said predetermined period of time a resilient individual ring according to claim 8.
18. A method of providing a predetermined amount of medroxyprogesterone acetate for a predetermined period of time to a female human, which consists essentially of retainably positioning within the vaginal tract of a said female human for said predetermined period of time a resilient individual ring according to claim 9.
19. The method of claim 10 wherein the ring is removed at the end of said predetermined period of time.
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3645258 *||Mar 17, 1970||Feb 29, 1972||Charis Aka Charilaos George Ma||Intrauterine device|
|US3656483 *||Jan 15, 1970||Apr 18, 1972||Biolog Concepts Inc||Intrauterine medicator|
|US3809076 *||Jun 16, 1971||May 7, 1974||Chabon I||Intrauterine contraceptive device|
|US3814097 *||Jan 24, 1973||Jun 4, 1974||Ici Ltd||Dressing|
|US3844285 *||Dec 14, 1972||Oct 29, 1974||Commw Scient Ind Res Org||Device for administration to ruminants|
|US3851648 *||Oct 11, 1973||Dec 3, 1974||Mead Johnson & Co||Zero-order release device|
|US3854476 *||Apr 5, 1973||Dec 17, 1974||Dickinson B||Intra-vaginal device and method|
|US3880991 *||Dec 29, 1970||Apr 29, 1975||Brook David E||Polymeric article for dispensing drugs|
|US3887699 *||Dec 29, 1970||Jun 3, 1975||Yolles Seymour||Biodegradable polymeric article for dispensing drugs|
|US3888975 *||Dec 27, 1972||Jun 10, 1975||Alza Corp||Erodible intrauterine device|
|US3892238 *||Jan 14, 1974||Jul 1, 1975||Abbott Lab||Drug supporting anchor|
|US3901232 *||Oct 26, 1973||Aug 26, 1975||Alza Corp||Integrated device for administering beneficial drug at programmed rate|
|US3911911 *||Mar 27, 1974||Oct 14, 1975||Reese Hospital Michael||Anti-fertility device|
|US3924622 *||Nov 26, 1974||Dec 9, 1975||Mead Johnson & Co||Zero-order release method|
|US3946106 *||Oct 24, 1974||Mar 23, 1976||G. D. Searle & Co.||Microsealed pharmaceutical delivery device|
|US3948263 *||Aug 14, 1974||Apr 6, 1976||Minnesota Mining And Manufacturing Company||Ballistic animal implant|
|US3973560 *||Jul 19, 1974||Aug 10, 1976||A. H. Robins Company, Incorporated||Intrauterine device of C or omega form|
|US3976071 *||Jan 7, 1974||Aug 24, 1976||Dynatech Corporation||Methods of improving control of release rates and products useful in same|
|US3991760 *||Dec 2, 1975||Nov 16, 1976||The Procter & Gamble Company||Vaginal medicament dispensing means|
|US3992518 *||Sep 29, 1975||Nov 16, 1976||G. D. Searle & Co.||Method for making a microsealed delivery device|
|US3995633 *||Dec 2, 1975||Dec 7, 1976||The Procter & Gamble Company||Vaginal Medicament dispensing device|
|US3996933 *||Oct 4, 1975||Dec 14, 1976||Morton Gutnick||Intrauterine contraceptive devices and processes|
|US4012497 *||Sep 23, 1975||Mar 15, 1977||Schering Aktiengesellschaft||Drug excipient of silicone rubber|
|US4014987 *||Jun 30, 1975||Mar 29, 1977||Alza Corporation||Device for delivery of useful agent|
|US4016251 *||May 30, 1975||Apr 5, 1977||Alza Corporation||Vaginal drug dispensing device|
|US4018220 *||Feb 23, 1976||Apr 19, 1977||Lionel C. R. Emmett||Method of insertion for intrauterine device of C or omega form with tubular inserter|
|US4024871 *||Jul 23, 1975||May 24, 1977||Ethicon, Inc.||Antimicrobial sutures|
|US4031886 *||Aug 30, 1976||Jun 28, 1977||Morhenn Vera B||Occlusive pessary|
|US4043339 *||Feb 2, 1976||Aug 23, 1977||The Upjohn Company||Method of and vaginal insert for prostaglandin administration|
|US4053580 *||Sep 20, 1976||Oct 11, 1977||G. D. Searle & Co.||Microsealed pharmaceutical delivery device|
|US4093490 *||Apr 29, 1977||Jun 6, 1978||Ortho Pharmaceutical Corporation||Method of making vaginal diaphragm|
|US4102998 *||Jul 1, 1976||Jul 25, 1978||Morton Gutnick||Process for the prevention of venereal disease|
|US4111196 *||Feb 23, 1976||Sep 5, 1978||Lionel C. R. Emmett||Intrauterine contraceptive device of c or omega form with tubular inserter and method of placement|
|US4155991 *||Mar 3, 1977||May 22, 1979||Schering Aktiengesellschaft||Vaginal ring|
|US4191741 *||Sep 22, 1978||Mar 4, 1980||Eli Lilly And Company||Removable drug implant|
|US4215691 *||Oct 11, 1978||Aug 5, 1980||Alza Corporation||Vaginal contraceptive system made from block copolymer|
|US4237885 *||Oct 23, 1978||Dec 9, 1980||Alza Corporation||Delivery system with mated members for storing and releasing a plurality of beneficial agents|
|US4250611 *||Apr 19, 1979||Feb 17, 1981||Alza Corporation||Process for making drug delivery device with reservoir|
|US4264575 *||Apr 8, 1980||Apr 28, 1981||Eli Lilly And Company||Contraceptive methods and compositions|
|US4264576 *||Apr 8, 1980||Apr 28, 1981||Eli Lilly And Company||Contraceptive methods and compositions|
|US4264577 *||Apr 8, 1980||Apr 28, 1981||Eli Lilly And Company||Contraceptive methods and compositions|
|US4264578 *||Apr 8, 1980||Apr 28, 1981||Eli Lilly And Company||Contraceptive methods and compositions|
|US4292965 *||Dec 29, 1978||Oct 6, 1981||The Population Council, Inc.||Intravaginal ring|
|US4310510 *||Oct 3, 1980||Jan 12, 1982||Sherman Kenneth N||Self administrable anti-fertility composition|
|US4326510 *||Nov 20, 1979||Apr 27, 1982||World Health Organization||Barrier contraceptive torus|
|US4344431 *||Aug 4, 1980||Aug 17, 1982||University Of Delaware||Polymeric article for dispensing drugs|
|US4402695 *||Mar 30, 1981||Sep 6, 1983||Alza Corporation||Device for delivering agent in vagina|
|US4469671 *||Feb 22, 1983||Sep 4, 1984||Eli Lilly And Company||Contraceptive device|
|US4589880 *||Jul 14, 1983||May 20, 1986||Southern Research Institute||Disposable spermicide-releasing diaphragm|
|US4629449 *||Mar 21, 1985||Dec 16, 1986||Alza Corporation||Vaginal dispenser for dispensing beneficial hormone|
|US4690683 *||Jul 2, 1985||Sep 1, 1987||Rutgers, The State University Of New Jersey||Transdermal varapamil delivery device|
|US4816257 *||Sep 2, 1987||Mar 28, 1989||Research & Education Institute, Harbor-Ucla Medical Center Inc.||Method for producing an in vivo environment suitable for human embryo transfer|
|US4985253 *||Feb 16, 1990||Jan 15, 1991||Sumitomo Pharmaceuticals Company, Limited||Sustained release composition for pharmaceutical substances comprising a silicone elastomer carrier|
|US5002540 *||May 22, 1989||Mar 26, 1991||Warren Kirschbaum||Intravaginal device and method for delivering a medicament|
|US5146931 *||Jun 8, 1990||Sep 15, 1992||Kurz Karl Heinz||Device to be placed in the uterus|
|US5181505 *||Jun 28, 1991||Jan 26, 1993||Lew Chel W||Method and apparatus for delivery of a medicament in the oral cavity|
|US5224493 *||Jan 30, 1991||Jul 6, 1993||Cadco Corporation||Contraceptive intracervical device and novel nonsystemic agents for the prevention of conception and disease|
|US5269321 *||Jul 14, 1992||Dec 14, 1993||Controlled Therapeutics (Scotland) Ltd.||Retrievable pessary|
|US5422118 *||Sep 21, 1992||Jun 6, 1995||Pure Pac, Inc.||Transdermal administration of amines with minimal irritation and high transdermal flux rate|
|US5788980 *||Oct 24, 1996||Aug 4, 1998||Roussel Uclaf||Intravaginal drug delivery device|
|US5855906 *||Dec 19, 1995||Jan 5, 1999||Galen (Chemicals) Limited||Intravaginal drug delivery devices for the administration of 17β-oestradiol precursors|
|US5972372 *||May 2, 1997||Oct 26, 1999||The Population Council, Inc.||Intravaginal rings with insertable drug-containing core|
|US6039968 *||Jun 22, 1998||Mar 21, 2000||Hoechst Marion Roussel||Intravaginal drug delivery device|
|US6126958 *||May 21, 1999||Oct 3, 2000||The Population Council, Inc.||Intravaginal rings with insertable drug-containing core|
|US6361780 *||Nov 12, 1998||Mar 26, 2002||Cardiac Pacemakers, Inc.||Microporous drug delivery system|
|US6423039||Apr 30, 1997||Jul 23, 2002||Interag||Synchronizing of animal oestrus and intra vaginal devices useful therein|
|US6486207||Dec 10, 1998||Nov 26, 2002||Nexmed (Holdings), Inc.||Compositions and methods for amelioration of human female sexual dysfunction|
|US6663608||Oct 11, 2001||Dec 16, 2003||Interag||Synchronizing of animal oestrus and intra vaginal devices useful therein|
|US6671562||Oct 28, 2002||Dec 30, 2003||Oscor Inc.||High impedance drug eluting cardiac lead|
|US6758840||Apr 20, 2001||Jul 6, 2004||Metris Therapeutics Limited||Drug delivery device|
|US6825234||Jul 2, 2002||Nov 30, 2004||Nexmed (Holdings) , Inc.||Compositions and methods for amelioration of human female sexual dysfunction|
|US7187980||Oct 28, 2002||Mar 6, 2007||Oscor Inc.||Cardiac lead with steroid eluting ring|
|US7824383||Nov 2, 2010||Family Health International||Vaginal drug delivery system and method|
|US7829112||Nov 9, 2010||The General Hospital Corporation||Methods and devices for the sustained release of multiple drugs|
|US7833545||Apr 29, 2004||Nov 16, 2010||The General Hospital Corporation||Methods and devices for the sustained release of multiple drugs|
|US7838024||May 22, 2008||Nov 23, 2010||The General Hospital Corporation||Methods and devices for the sustained release of multiple drugs|
|US7883718||Feb 8, 2011||The General Hospital Corporation||Methods and devices for the sustained release of multiple drugs|
|US7910126||Mar 22, 2011||Teva Women's Health, Inc.||Flexible, compressed intravaginal rings, methods of making and using the same, and apparatus for making the same|
|US8217219||Jul 10, 2012||Kimberly-Clark Worldwide, Inc.||Anatomically conforming vaginal insert|
|US8323679||Dec 4, 2012||Teva Women's Health, Inc.||Flexible, compressed intravaginal rings, methods of making and using the same, and apparatus for making the same|
|US8333983 *||May 19, 2004||Dec 18, 2012||Msd Oss B.V.||Drug delivery system|
|US8404272 *||Mar 26, 2013||Poly-Med, Inc.||Fiber-reinforced composite rings for intravaginal controlled drug delivery|
|US8506543||Jun 11, 2012||Aug 13, 2013||Kimberly-Clark Worldwide, Inc.||Anatomically conforming vaginal insert|
|US8580293||Feb 3, 2009||Nov 12, 2013||Teva Women's Health, Inc.||Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof|
|US8580294||Oct 19, 2011||Nov 12, 2013||International Partnership For Microbicides||Platinum-catalyzed intravaginal rings|
|US8715712||Nov 28, 2012||May 6, 2014||Forsight Vision5, Inc.||Ocular insert apparatus and methods|
|US8741329||Sep 19, 2008||Jun 3, 2014||Merck Sharp & Dohme B.V.||Drug delivery system|
|US8753667||Apr 7, 2010||Jun 17, 2014||The Population Council, Inc.||Multi-layered gradient vaginal ring|
|US8858977 *||Nov 9, 2012||Oct 14, 2014||Merck Sharp & Dohme B.V.||Drug delivery system|
|US8865200 *||Jul 8, 2005||Oct 21, 2014||Laboratoire Hra Pharma||Sustained release compositions containing progesterone receptor modulators|
|US8939948||Sep 14, 2012||Jan 27, 2015||Forsight Vision5, Inc.||Ocular insert apparatus and methods|
|US9084717||Feb 14, 2013||Jul 21, 2015||Poly-Med, Inc.||Partially absorbable fiber-reinforced composites for controlled drug delivery|
|US9095744 *||Jun 4, 2013||Aug 4, 2015||Caryn M. Horsley||Medical exercise device|
|US20030093136 *||Oct 28, 2002||May 15, 2003||Osypka Thomas P.||Cardiac lead with steroid eluting ring|
|US20040265355 *||Jun 3, 2004||Dec 30, 2004||Shalaby Shalaby W.||Composite absorbable/biodegradable rings for controlled drug delivery|
|US20050042292 *||Mar 27, 2003||Feb 24, 2005||Brendan Muldoon||Intravaginal matrix drug delivery devices|
|US20050148995 *||Dec 29, 2003||Jul 7, 2005||Kimberly-Clark Worldwide, Inc.||Anatomically conforming vaginal insert|
|US20060270640 *||Feb 17, 2005||Nov 30, 2006||Mercian Corporation||Method of preventing, medicating, and/or treating hypocalcemia of domestic mammal|
|US20060280771 *||May 19, 2004||Dec 14, 2006||Akzo Nobel N.V.||Drug delivery system|
|US20070191320 *||Dec 29, 2006||Aug 16, 2007||Nexmed Holdings, Inc.||Methods of treatment for female sexual arousal disorder|
|US20070196433 *||Apr 29, 2004||Aug 23, 2007||The Massachusetts General Hospital Corporation||Methods and devices for the sustained release of multiple drugs|
|US20070254014 *||Mar 20, 2007||Nov 1, 2007||Ahmed Salah U||Flexible, compressed intravaginal rings, methods of making and using the same, and apparatus for making the same|
|US20080051740 *||Jun 14, 2007||Feb 28, 2008||Family Health International||Vaginal drug delivery system and method|
|US20080199511 *||Jul 8, 2005||Aug 21, 2008||Laboratoire Hra Pharma||Sustained Release Compositions Containing Progesterone Receptor Modulators|
|US20080248017 *||May 22, 2008||Oct 9, 2008||Massachusetts Institute Of Technology||Methods and devices for the sustained release of multiple drugs|
|US20080286322 *||May 22, 2008||Nov 20, 2008||The General Hospital Corporation D/B/A Massachusetts General Hospital||Methods and devices for the sustained release of multiple drugs|
|US20080286339 *||May 22, 2008||Nov 20, 2008||The General Hospital Corporation D/B/A Massachusetts General Hospital||Methods and devices for the sustained release of multiple drugs|
|US20090060982 *||May 22, 2008||Mar 5, 2009||The General Hospital Corporation D/B/A Massachusetts General Hospital||Methods and devices for the sustained release of multiple drugs|
|US20090081278 *||Sep 19, 2008||Mar 26, 2009||N.V. Organon||Drug Delivery System|
|US20090202612 *||Feb 3, 2009||Aug 13, 2009||Ahmed Salah U||Monolithic Intravaginal Rings Comprising Progesterone and Methods of Making and Uses Thereof|
|US20090274654 *||Nov 5, 2009||The General Hospital Corporation D/B/A Massachusetts General Hospital||Methods and devices for the sustained release of multiple drugs|
|US20110212155 *||Sep 1, 2011||Ahmed Salah U||Flexible, Compressed Intravaginal Rings, Methods of Making and Using the Same, and Apparatus for Making the Same|
|US20110236462 *||Sep 29, 2011||Shaked Ze Ev||Intravaginal drug delivery device|
|US20130078286 *||Mar 28, 2013||Msd Oss B.V.||Drug delivery system|
|US20130324380 *||Jun 4, 2012||Dec 5, 2013||Caryn M. Horsley||Medical exercise device|
|US20160016040 *||Jul 1, 2015||Jan 21, 2016||Caryn M. Horsley||Medical Exercise Device|
|CN101080205B||Jul 8, 2005||Oct 12, 2011||Hra药物实验室||Sustained release compositions containing progesterone receptor modulators|
|DE2547378A1 *||Oct 23, 1975||Apr 29, 1976||Searle & Co||Vorrichtung mit abgeschlossenen mikrokammern zur abgabe eines arzneimittels|
|DE2818934A1 *||Apr 28, 1978||Nov 9, 1978||Ortho Pharma Corp||Vaginaldiaphragma und verfahren zu dessen herstellung|
|EP0010987A1 *||Nov 5, 1979||May 14, 1980||Beecham Group Plc||Device for oral administration to a ruminant animal|
|EP0050867A1 *||Oct 24, 1981||May 5, 1982||Schering Aktiengesellschaft||Vaginal ring|
|EP0776659A1 *||Oct 30, 1996||Jun 4, 1997||Roussel Uclaf||Delivery device for medicaments by the intravaginal route|
|EP1159957A2||Dec 2, 1997||Dec 5, 2001||Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)||Device for the local administration of solid or semi-solid formulations, sustained release formulations for parenteral administration and process of preparation|
|EP1768625A2 *||Jul 8, 2005||Apr 4, 2007||The Population Council, Inc.||Sustained release compositions containing progesterone receptor modulators|
|EP2244782A2 *||Jan 23, 2009||Nov 3, 2010||The University of Utah Research Foundation||Linear order release polymer|
|EP2246062A1||Jul 19, 2006||Nov 3, 2010||The Population Council, Inc.||Methods and compositions for emergency contraception using endothelin receptor antagonists|
|EP2359807A1||Feb 3, 2009||Aug 24, 2011||Teva Women's Health, Inc.||Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof|
|EP2641602A1||Mar 23, 2012||Sep 25, 2013||PregLem S.A.||Method for treating gynecological diseases|
|WO1995000118A1 *||Jun 8, 1994||Jan 5, 1995||Leiras Oy||Intra-uterine ring for the release of an active agent, such as a hormone, and an introducer|
|WO1995009641A1 *||Oct 3, 1994||Apr 13, 1995||Lectin Biopharma, Inc.||Using lectins for contraception, prophylaxis and therapy|
|WO1996019196A1 *||Dec 19, 1995||Jun 27, 1996||Galen (Chemicals) Limited||INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS|
|WO1997040776A1 *||Apr 30, 1997||Nov 6, 1997||Dec International Nz Limited||Synchronising of animal oestrus and intra vaginal devices useful therein|
|WO2009099586A2||Feb 3, 2009||Aug 13, 2009||Duramed Pharmaceuticals, Inc.||Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof|
|WO2013140372A1||Mar 22, 2013||Sep 26, 2013||Preglem Sa||Method for treating gynecological diseases|
|WO2014167510A2||Apr 9, 2014||Oct 16, 2014||Preglem Sa||Progesteron receptor modulators for use in the therapy of uterine fibroids|
|WO2015055789A1||Oct 16, 2014||Apr 23, 2015||Bayer Pharma Aktiengesellschaft||INTRAVAGINAL USE OF 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, INTRAVAGINAL RINGS COMPRISING 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, AND USE THEREOF IN CONTRACEPTION|
|U.S. Classification||128/832, 604/93.1, 604/515, 424/432|
|International Classification||A61F6/08, A61M31/00, A61D7/00, C07C405/00, A61K9/00, A61F6/06, A61F6/00, A61K31/557|
|Cooperative Classification||A61K9/0036, C07C405/00, A61F6/08, A61D7/00, A61K31/557, A61M31/002|
|European Classification||A61M31/00D, C07C405/00, A61F6/08, A61K31/557, A61D7/00, A61K9/00M8B|