|Publication number||US3547119 A|
|Publication date||Dec 15, 1970|
|Filing date||Dec 8, 1967|
|Priority date||Dec 8, 1967|
|Also published as||DE1812394A1|
|Publication number||US 3547119 A, US 3547119A, US-A-3547119, US3547119 A, US3547119A|
|Inventors||Farb Richard B, Hall John P|
|Original Assignee||Baxter Laboratories Inc|
|Export Citation||BiBTeX, EndNote, RefMan|
|Referenced by (118), Classifications (6) |
|External Links: USPTO, USPTO Assignment, Espacenet|
US 3547119 A
United States Patent  Inventors John P. Hall Niles; Richard B. Farb, Chicago, Ill.  App1.No. 689,099  Filed Dec. 8, 1967  Patented Dec. 15, 1970  Assignee Baxter Laboratories, Inc.
Morton Grove, Ill. a corporation of Delaware  CATHETER ASSEMBLY 6 Claims, 3 Drawing Figs.
 U.S. Cl 128/214.4, 128/348  Int. Cl A61m 5/00  Field oiSearch 128/2l4.4, 221, 215, 347-351  References Cited UNITED STATES PATENTS 1,120,549 12/1914 Schellberg 128/349 2,898,917 8/1959 Wallace 128/350 l I I/IIIIIIII /l ll/I IIII. 'IIIIIIIIII/I/I IIIIIIIIII/I 2,937,643 5/1960 Elliot l28/2l4.4 3,185,151 5/1965 Czorny..... l28/2l4.4 3,313,299 4/1967 Spademan 128/2 14.4 3,314,427 4/1967 Stafford 128/2l4.4 3,444,860 5/1969 Harrell 128/349 3,459,184 8/1969 Ring l28/2l4.4 3,459,188 8/1969 Roberts 128/347 FOREIGN PATENTS 1,064,445 12/1953 France l28/2l4.4 OTHER REFERENCES Lancet- Sept. l4,1963,pg.557 128/349 Primary ExaminerDalton L. Truluck Attorneys-Robert G. Pollock and Richard .1. Reilly ABSTRACT: The distal portion of a collapsible housing is secured to a catheter comprising said assembly to provide an enclosure from which said tubular member can be projected into a body opening through an aperture in the body. An apertured connector is carried from the proximal portion of said housing for securance to the body about the body aperture for passing the catheter directly from the housing into the body opening.
PATENTED nun 5 I910 It II ll Inventor John R Hall Richard B. Farb Byfiz zazzzrffeily Attorney CATHETER ASSEMBLY The present invention relates to catheters. Particularly the inventionrelates' to an assembly for passing fluids into and out of a body cavity through a catheter while minimizing exposure thereof to airborne contaminants.
A catheter, such as the type used for peritoneal dialysis, is part of an assembly which conventionally may include a stylet mounted in the lumen of the catheter for relative axial displacement. The stylet is adapted initially to incise abody wall to generate an opening through which the catheter maybe projected into the peritoneal cavity. Prior to the present invention, the noninserted section of a catheter would be exposed to the air. Consequently, upon subsequent insertion of previously exposed catheter parts contaminating organisms might be introduced into the peritoneal cavity.
It is the object of the present invention to provide anew catheter assembly. 7 j
It is a further .object of the invention to reduce the risk of catheter contamination from the risk level prevailing prior to this invention.
The foregoing objects are achieved by providing a housing in an assembly for passage of'a liquid relative a'body opening through a body aperture. A catheter with a distal end section has a proximal end section arranged for projection from said housing for insertion through said body aperture into 'thebody opening. The catheter is also arranged for movement between a first condition in which said distal section is wholly disposed in said housing and a second condition in which a-portion of said distal section projects from said housing for insertion'into said body opening through said body aperture. Also provided are first connecting means securing said housing to said distal section for adjusting said catheter between said first and second condition.
The foregoing and other objects, features and advantages of the invention will become more apparent .upon consideration of the following description and appended claims when considered in conjunction with the accompanying drawings wherein the same reference character or numeral refers to like or corresponding parts throughout the several views.
On the drawings:
FIG. 1 is a side perspective of an assembly embodying one form of the invention and including a housing and acatheter having distal end section disposed in said housing.
FIG. 2 is a view similar to FIG. 1, however showing the catheter conditioned so that parts of the distal end section project from said housing and parts broken away for the purpose of illustration.
FIG. 3 is a longitudinal sectional view of said-assembly but on a larger scale than the scale FIG. 1, with parts broken out to conserve drawing area.
Referring now more particularly to the drawings, an assembly generally designated comprises a catheter 12 of conventional fabrication and which may, but need not be, adapted for peritoneal dialysis. Catheter 12 has a proximal end section 14 and a distal end section 16, proximal end section 14 being shown having a plurality of axially spaced apertures 18 (only some of which have been numbered in FIGS. 1 and 3) to facilitate fluid passage to and from the lumen 20 of catheter 12 out of and into a body cavity (not shown). Moreover, said proximal end section may be tapered as at 22 to facilitate catheter penetration into a body cavity through an aperture in a body wall (not shown) made by the incising end 24 of a stylet 26 which is normally slidably disposed for removal in lumen 20. Stylet 26 may be of conventional fabrication for rigid construction and is adapted for incising projection outwardly from the catheter end section 14.
In the present embodiment a plastic valve housing 28 is frictionally secured to the outermost part of distal end section 16 through the medium of a catheter hub 30 which is carried on distal end section 16 and plugs inner end 32 of said valve housing. The arrangement is such that when stylet 26 is removed from lumen 20, valve chamber 34 is in fluid communication with said lumen.
Not critical to the invention are a .pair of self-sealing valves 36 and 38 (herein shown as Foley valves) which are anchored in extensions 40 and 42, respectively, of valve housing 28. Extension 40 is aligned with catheter lumen 20 so that outer portion 44 of stylet 26 may project through valve 36 in a manner such that by gripping handle 48, stylet 26 may be manually withdrawn from and inserted into lumen 20.
A longitudinally collapsible housing 50 which may be fabricated from polyethylene is disposed about distal end section 16 of said catheter for barring entry into its chamber 51 of contaminants from the air. Proximal end section 14 of said catheter, however, normally extends outwardly from the inner end portion .56 of said housing. Housing 50 has an outer reduced end portion 52 which is anchored on the inner end 32 of-valve housing 28'by means of a shrunkenmodified polyvinylchloride plastic collar54 whereby housing end portion 52 is arranged for: axial movement with catheter 12. Accordingly,
when inner end portion 56 is anchored in a relatively fixed position, parts of distal end section 16 may be projected from chamber 51 to elongate the partof catheter 12 outside housing 50, by collapsing said housing to a condition, for example, shown'in FIG. 3. The means for extending distal end section 16 from within housing 50 upon its collapse includes collar 54 as well as hub 30.
Connecting means for securing inner end. portion 56 of housing 50 to apatient (not shown) and, accordingly, a relatively fixed position with respect to outer end portion 52 comprisesa disc 58 disposed adjacent said housing and from which catheter 12 projects for entry into bodycavity of such patient. Disc 58 may be of vinyl fabrication with a tacky Mylar polyester facing -60 adapted to secure disc 58 to the body surface of a patient. Said'disc is apertured asat 62 for-extension and withdrawal of distal catheter portion 16 into .and'out of housing 50 and, accordingly, elongation and shortening of the part of catheter 12 which projects away from disc 58.
An apertured member 64 in the form of a hub for disc 58. and preferably integrally fashioned therewith defines and axially disposed passage 66 in which catheter 12 is arranged in bearing relationship for axial movement. Member 64 projects from disc 58 into housing 50 through an inner end'opening defined by inner end portion 56 of said housing. Said inner end portion is secured to member 64 and accordingly to disc 7 58 by shrinkable modified polyvinylchloride collar 68 which may be of a fabrication similar to the collar 54 and is shrunken to impinge said inner end portion on member 64.
The manner in which assembly 10 operates is as follows: with housing 50 distended as in FIGS. 1 and 3, an incision is made in the body wall of a patient with stylet 12 to provide an aperture for passing the inner end section 14 catheter 12 into a body opening such as the peritoneal cavity. While housing 50in its extended condition FIGS. 1 and 3), assembly 10 is advanced to insert proximal end section 14in the body cavity or opening and engage disc 58 to the body-surface, with its aperture 62 in registration with the incision in the body wall. Thereafter, tacky facing 60 is pressed into securance with the body wall and stylet 26 removed.
The foregoing arrangement enables catheter 12 to be moved between a first condition in which distal end section 16 is disposed within housing 50 and a second condition in which said distal end section is projected from said housing by moving the outer end portion 52 of said housing to the right from its position of FIG. 3 toward the position of FIG. 2. This feature of course permits adjusting the length of the catheter 7 while is disposed within the body cavity. Moreover, other adjustments in catheter extension in the body of a patient may be made from time to time by, for example, partially extending housing 50; and at no time after initial securance of the assembly to the patients body will the catheter be exposed to the air. Thereby, catheter contamination from that source is prevented.
As many substitutions or changes could be made in the above described construction and as many apparently widely different embodiments of the invention within the scope of the claims could be constructed without the departing from the scope and spirit thereof, it is intended that all matter contained in the accompanying specification shall be interpreted as being illustrative and not in a limiting sense.
1. An assembly for inserting a catheter into a living body while preventing airborne contamination thereof, which comprises: a housing for enclosing a major portion of said catheter in excluded relation from the exterior, said housing having a first aperture in one end thereof of size sufficient to pass said catheter, a catheter attached at one location within said housing and disposed in generally axial relation thereto, said attached catheter having an open bore for fluid communication therethrough, the housing having a flexible tubular portion, which portion is longitudinally expansible and contractible to enclose a major portion of said catheter in expanded position and to expel a portion of the said catheter through said aperture by moving into contracted position, a second aperture in the other end of said housing, puncturing means consisting of a removable stylet having a sharpened point passing longitudinally through said housing apertures and said catheter bore to assist in the insertion of the catheter into said body and an by a pair of bands impinging the ends of said tubular portion 4. The assembly of claim 3 having a third aperture located adjacent said second aperture for connection to said assembly while the stylet is in said catheter bore. I
5. The assembly of claim 3 in which said'catheter has a tapered end for ease of insertion.
6. The assembly of claim 3 in which said housing comprises a distal valve housing and a proximal member connected respectively to opposite ends of said flexible tubular portion about said distal valve housing and proximal member respectively, said proximal member defining the'first aperture and said distal valve housing defining the second aperture.
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3698396 *||Dec 4, 1970||Oct 17, 1972||Abbott Lab||Catheter assembly for peritoneal cavity insertion|
|US3739778 *||Aug 12, 1971||Jun 19, 1973||Bard Inc C R||Catheter introduction system|
|US4016879 *||Apr 7, 1975||Apr 12, 1977||Dynasciences Corporation||Multi-mode cannulating apparatus|
|US4073297 *||Feb 11, 1976||Feb 14, 1978||Sandoz Ltd.||Catheter|
|US4160450 *||Jul 15, 1977||Jul 10, 1979||Doherty George O||Outside-the-needle catheter device with needle housing|
|US4180074 *||Mar 15, 1977||Dec 25, 1979||Fibra-Sonics, Inc.||Device and method for applying precise irrigation, aspiration, medication, ultrasonic power and dwell time to biotissue for surgery and treatment|
|US4224943 *||Jan 24, 1979||Sep 30, 1980||Sorenson Research Co., Inc.||Cannula and method for bidirectional blood flow|
|US4230128 *||Mar 30, 1978||Oct 28, 1980||Aramayo Rene S||Catheter attachment for blood sampling|
|US4308875 *||Mar 11, 1981||Jan 5, 1982||Universal Medical Instrument Corporation||Amniocentesis needle|
|US4317445 *||Mar 31, 1980||Mar 2, 1982||Baxter Travenol Laboratories, Inc.||Catheter insertion unit with separate flashback indication for the cannula|
|US4318401 *||Apr 24, 1980||Mar 9, 1982||President And Fellows Of Harvard College||Percutaneous vascular access portal and catheter|
|US4405319 *||Sep 18, 1981||Sep 20, 1983||Renal Systems, Inc.||Porous titanium coating for blood access device|
|US4496349 *||Oct 26, 1981||Jan 29, 1985||Renal Systems, Inc.||Percutaneous implant|
|US4512768 *||Feb 15, 1983||Apr 23, 1985||Avvari Rangaswamy||Analgesic syringe|
|US4650474 *||Dec 20, 1984||Mar 17, 1987||Laboratoires Biotrol||Device for elimination of urine through ureterostoma|
|US4664660 *||Apr 1, 1985||May 12, 1987||Becton, Dickinson And Company||Chest drainage apparatus with ambient air sealing|
|US4755173 *||Jun 4, 1987||Jul 5, 1988||Pacesetter Infusion, Ltd.||Soft cannula subcutaneous injection set|
|US5300046 *||Sep 23, 1992||Apr 5, 1994||Symbiosis Corporation||Thoracentesis sheath catheter assembly|
|US5352210 *||Sep 15, 1992||Oct 4, 1994||Piero Marrucchi||Method and device for manipulating and transferring products between confined volumes|
|US5360406 *||Jul 7, 1993||Nov 1, 1994||Minnesota Mining And Manufacturing Company||Stylet for retrograde coronary sinus cannula|
|US5395352 *||Jan 21, 1994||Mar 7, 1995||Scimed Lift Systems, Inc.||Y-adaptor manifold with pinch valve for an intravascular catheter|
|US5401244 *||Apr 28, 1994||Mar 28, 1995||Minnesota Mining And Manufacturing Company||Method of, and stylet apparatus for, installing a retrograde coronary cannula|
|US5545143 *||Jan 7, 1994||Aug 13, 1996||T. S. I. Medical||Device for subcutaneous medication delivery|
|US5676656 *||Jul 24, 1996||Oct 14, 1997||Becton Dickinson And Company||Control forward introducer needle and catheter assembly|
|US5683370 *||Nov 21, 1996||Nov 4, 1997||Luther Medical Products, Inc.||Hard tip over-the-needle catheter and method of manufacturing the same|
|US5697914 *||Mar 16, 1995||Dec 16, 1997||Becton Dickinson And Company||Control forward/flashback forward one hand introducer needle and catheter assembly|
|US5702368 *||May 30, 1995||Dec 30, 1997||Heartport, Inc.||In an endovascular system|
|US5743883 *||Jun 7, 1995||Apr 28, 1998||Visconti; Peter L.||Thoracentesis catheter instruments having self-sealing valves|
|US5769812 *||Oct 16, 1996||Jun 23, 1998||Heartport, Inc.||System for cardiac procedures|
|US5792094 *||Sep 28, 1995||Aug 11, 1998||Heartport, Inc.||Method of delivering cardioplegic fluid to a patient's heart|
|US5800375 *||Dec 20, 1995||Sep 1, 1998||Heartport, Inc.||Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery|
|US5879334 *||May 8, 1996||Mar 9, 1999||Becton Dickinson And Company||Control forward introducer needle and catheter assembly|
|US5885238 *||May 30, 1995||Mar 23, 1999||Heartport, Inc.||System for cardiac procedures|
|US5913848 *||Jun 6, 1996||Jun 22, 1999||Luther Medical Products, Inc.||Hard tip over-the-needle catheter and method of manufacturing the same|
|US5916208 *||Nov 21, 1996||Jun 29, 1999||Luther Medical Products, Inc.||Hard tip over-the-needle catheter and method of manufacturing the same|
|US5935110 *||Jul 22, 1997||Aug 10, 1999||Becton Dickinson And Company||Control forward/flashback forward one hand introducer needle and catheter assembly|
|US5957893 *||Sep 8, 1998||Sep 28, 1999||Becton Dickinson & Co.||Hard tip over-the needle catheter and method of manufacturing the same|
|US6017328 *||Aug 12, 1996||Jan 25, 2000||Magnolia Medical, Llc||Device for subcutaneous medication delivery|
|US6090096 *||Apr 23, 1997||Jul 18, 2000||Heartport, Inc.||Antegrade cardioplegia catheter and method|
|US6217556||Mar 19, 1998||Apr 17, 2001||Allegiance Corporation||Drainage catheter|
|US6398752||Jun 5, 1998||Jun 4, 2002||William P. Sweezer, Jr.||Method of occluding a patient's ascending aorta and delivery cardioplegic fluid|
|US6506181||May 25, 2001||Jan 14, 2003||Becton, Dickinson And Company||Catheter having a low drag septum|
|US6932792||Jul 17, 2000||Aug 23, 2005||Frederick G. St. Goar||Antegrade cardioplegia catheter and method|
|US6982264||Jun 27, 2002||Jan 3, 2006||Elan Pharmaceuticals, Inc.||Enzyme inhibitors of beta-secretase-mediated cleavage of amyloid precuror proteins; congnition activators; Down's syndrome; Hereditary Cerebral Hemorrhage with Amyloidosis of the Dutch-type; Parkinson's disease; hemostatic agents|
|US7083597||Jun 17, 2003||Aug 1, 2006||Applied Diabetes Research, Inc.||Pivoting joint infusion system with seal|
|US7214207||Mar 7, 2003||May 8, 2007||Applied Diabetes Research, Inc.||Low profile, pivotal connection infusion assembly|
|US7338465||Jul 2, 2002||Mar 4, 2008||Patton Medical Devices, Lp||Infusion device and method thereof|
|US7407493||Jun 22, 2004||Aug 5, 2008||Unomedical A/S||Container for disposable needle or cannula|
|US7407973||Oct 21, 2004||Aug 5, 2008||Intermune, Inc.||Adjusting dosage in response to the comparison of pretreatment levels of stress-activated protein kinase activity to posttreatment levels in treating fibrotic disorder, carcinoma, sarcoma, leukemia, lymphoma, viral infection, inflammatory disorder and tumor necrosis factor-mediated disorder|
|US7524300||Jul 7, 2006||Apr 28, 2009||Patton Medical Devices, Lp||Infusion device|
|US7569034||Jan 4, 2002||Aug 4, 2009||Lynch George R||Low profile pivoting joint infusion assembly|
|US7585287||Jun 16, 2004||Sep 8, 2009||Smiths Medical Md, Inc.||Device and method for insertion of a cannula of an infusion device|
|US7648494||Mar 21, 2005||Jan 19, 2010||Unomedical A/S||Infusion set and injector device for infusion set|
|US7699807||Nov 10, 2003||Apr 20, 2010||Smiths Medical Asd, Inc.||Device and method for insertion of a cannula of an infusion device|
|US7699808||Nov 10, 2003||Apr 20, 2010||Smiths Medical Asd, Inc.||Subcutaneous infusion device and method|
|US7704228||Sep 18, 2006||Apr 27, 2010||Patton Medical Devices, Lp||Infusion device|
|US7731680||Sep 18, 2006||Jun 8, 2010||Patton Medical Devices, Lp||Infusion device|
|US7731691||Nov 10, 2003||Jun 8, 2010||Smiths Medical Asd, Inc.||Subcutaneous infusion device and device for insertion of a cannula of an infusion device and method|
|US7766867||Mar 21, 2007||Aug 3, 2010||Applied Diabetes Research, Inc.||Low profile, pivotal connection infusion assembly|
|US7781474||Jul 5, 2007||Aug 24, 2010||Intermune, Inc.||Inhibitors of hepatitis C virus replication|
|US7850658||Aug 13, 2004||Dec 14, 2010||Smiths Medical Asd, Inc.||Subcutaneous infusion device and method including release feature for adhesive portion|
|US7862545||Jun 22, 2006||Jan 4, 2011||Applied Diabetes Research, Inc.||Pivoting joint infusion system with steal|
|US7932277||May 9, 2008||Apr 26, 2011||Intermune, Inc.||Peptide inhibitors of hepatitis C virus replication|
|US7935090||Sep 18, 2006||May 3, 2011||Patton Medical Devices, Lp||Infusion device|
|US7985199||Feb 22, 2006||Jul 26, 2011||Unomedical A/S||Gateway system|
|US7993306||Oct 31, 2006||Aug 9, 2011||Smiths Medical Asd, Inc.||Subcutaneous infusion device and method including tapered cannula|
|US8012126||Oct 29, 2007||Sep 6, 2011||Unomedical A/S||Infusion set|
|US8062250||Dec 23, 2004||Nov 22, 2011||Unomedical A/S||Cannula device|
|US8152771||Oct 15, 2003||Apr 10, 2012||Unomedical A/S||Injector device for placing a subcutaneous infusion set|
|US8162890 *||May 6, 2007||Apr 24, 2012||Flexicath Ltd.||Catheter insertion apparatus and method of use thereof|
|US8162892||Mar 29, 2004||Apr 24, 2012||Unomedical A/S||Injector device for placing a subcutaneous infusion set|
|US8172805||Jan 7, 2005||May 8, 2012||Unomedical A/S||Injector device for placing a subcutaneous infusion set|
|US8216208||Jul 7, 2006||Jul 10, 2012||Patton Medical Devices, Lp||Method relating to infusion device|
|US8221355||Mar 21, 2005||Jul 17, 2012||Unomedical A/S||Injection device for infusion set|
|US8221361||Mar 10, 2006||Jul 17, 2012||Patton Medical Devices, Lp||Infusion devices|
|US8221362||Sep 18, 2006||Jul 17, 2012||Patton Medical Devices, Lp||Infusion device|
|US8221386||Jul 7, 2006||Jul 17, 2012||Patton Medical Devices, Lp||Method relating to infusion device|
|US8226614||Nov 3, 2006||Jul 24, 2012||Patton Medical Devices, Lp||Fluid delivery devices, systems and methods|
|US8246588||Jul 3, 2008||Aug 21, 2012||Unomedical A/S||Insertion device with pivoting action|
|US8262627||Sep 18, 2006||Sep 11, 2012||Patton Medical Devices, Lp||Infusion device|
|US8277418||Nov 22, 2010||Oct 2, 2012||Alcon Research, Ltd.||Ophthalmic valved trocar cannula|
|US8287516||Mar 21, 2005||Oct 16, 2012||Unomedical A/S||Infusion set|
|US8303549||Dec 22, 2006||Nov 6, 2012||Unomedical A/S||Injection device|
|US8343106||Nov 22, 2010||Jan 1, 2013||Alcon Research, Ltd.||Ophthalmic valved trocar vent|
|US8343115||Aug 3, 2009||Jan 1, 2013||Applied Diabetes Research, Inc.||Low profile pivoting joint infusion assembly|
|US8366683||Mar 4, 2008||Feb 5, 2013||Patton Medical Devices, Lp||Infusion devices|
|US8398586||Jun 28, 2010||Mar 19, 2013||Applied Diabetes Research Incorporated||Low profile, pivotal connection infusion assembly|
|US8430850||Jul 2, 2008||Apr 30, 2013||Unomedical A/S||Inserter having bistable equilibrium states|
|US8439838||Jun 7, 2007||May 14, 2013||Unomedical A/S||Inserter for transcutaneous sensor|
|US8486003||Jul 2, 2008||Jul 16, 2013||Unomedical A/S||Inserter having two springs|
|US8551047||Aug 22, 2006||Oct 8, 2013||Patton Medical Devices, Lp||Fluid delivery devices, systems and methods|
|US8562567||Jul 16, 2010||Oct 22, 2013||Unomedical A/S||Inserter device with horizontal moving part|
|US8603034||Sep 21, 2005||Dec 10, 2013||Applied Diabetes Research, Inc.||One piece sealing reservoir for an insulin infusion pump|
|US8613728||Nov 6, 2006||Dec 24, 2013||Flexicath Ltd.||Removable adapter for a splittable introducer and method of use thereof|
|US8679064||Aug 13, 2012||Mar 25, 2014||Alcon Research, Ltd.||Ophthalmic valved trocar cannula|
|US8777925||Mar 4, 2008||Jul 15, 2014||Medtronic Minimed, Inc.||Methods relating to infusion device|
|US8790311||Jun 8, 2007||Jul 29, 2014||Unomedical A/S||Mounting pad|
|US8795309||Jul 27, 2010||Aug 5, 2014||Smiths Medical Asd, Inc.||Device for insertion of a cannula of an infusion device and method|
|CN101500636B||May 6, 2007||May 30, 2012||弗莱克希凯斯有限公司||Catheter insertion apparatus and method of use thereof|
|DE3153686C2 *||Apr 24, 1981||Jan 23, 1992||President And Fellows Of Harvard College, Cambridge, Mass., Us||Title not available|
|EP0411605A1 *||Aug 1, 1990||Feb 6, 1991||Terumo Kabushiki Kaisha||Catheter and assembly for extracorporeal circulation|
|EP2103623A2||Jul 17, 2006||Sep 23, 2009||Intermune, Inc.||Novel macrocyclic inhibitors of Hepatitis C virus replication|
|EP2177523A1||May 2, 2008||Apr 21, 2010||Intermune, Inc.||Novel macrocyclic inhibitors of hepatitis c virus replication|
|EP2305695A2||Jul 17, 2006||Apr 6, 2011||Intermune, Inc.||Macrocyclic inhibitors of Hepatitis C virus replication|
|EP2305696A2||Jul 17, 2006||Apr 6, 2011||Intermune, Inc.||Macrocyclic inhibitors of Hepatitis C virus replication|
|EP2305697A2||Jul 17, 2006||Apr 6, 2011||Intermune, Inc.||Macrocyclic inhibitors of Hepatitis C virus replication|
|EP2305698A2||Jul 17, 2006||Apr 6, 2011||Intermune, Inc.||Macrocyclic inhibitors of Hepatitis C virus replication|
|EP2390262A1||May 13, 2004||Nov 30, 2011||Intermune, Inc.||Synthetic chemokine receptor ligands and methods of use thereof|
|EP2407470A2||Oct 13, 2004||Jan 18, 2012||F. Hoffmann-La Roche Ltd.||Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication|
|WO1982003003A1 *||Nov 2, 1981||Sep 16, 1982||Young Ruperto S||An amniocentesis needle|
|WO1996021486A1 *||Mar 21, 1995||Jul 18, 1996||Chin Rong Hwang||Single outlet vascular catheterism device|
|WO2005037214A2||Oct 13, 2004||Apr 28, 2005||Intermune Inc||Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication|
|WO2007044893A2||Oct 10, 2006||Apr 19, 2007||Intermune Inc||Compounds and methods for inhibiting hepatitis c viral replication|
|WO2007132444A2 *||May 6, 2007||Nov 22, 2007||Shai Amisar||Catheter insertion apparatus and method of use thereof|
|WO2008137779A2||May 2, 2008||Nov 13, 2008||Intermune Inc||Novel macrocyclic inhibitors of hepatitis c virus replication|
|WO2010045266A1||Oct 13, 2009||Apr 22, 2010||Intermune, Inc.||Therapeutic antiviral peptides|
|WO2010099458A1||Feb 26, 2010||Sep 2, 2010||Intermune, Inc.||Combination of a nucleoside polymerase inhibitor with a macrocyclic protease inhibitor and use thereof in the treatment of hepatitis c, liver fibrosis and impaired liver function|
|WO2011038293A1||Sep 24, 2010||Mar 31, 2011||Intermune, Inc.||Cyclic peptide inhibitors of hepatitis c virus replication|