|Publication number||US3563240 A|
|Publication date||Feb 16, 1971|
|Filing date||Jul 20, 1966|
|Priority date||Jul 20, 1966|
|Publication number||US 3563240 A, US 3563240A, US-A-3563240, US3563240 A, US3563240A|
|Original Assignee||Jules Silver|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (4), Referenced by (69), Classifications (13), Legal Events (4)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent 218M, 218N, 218NV, 218?, 218PA, 218.1, 218.2, 221, 272; 222/145, 309; 128/225, 234, 235, 239, 261
ll, /0 ll  References Cited UNITED STATES PATENTS 2,856,925 10/1958 Helmer et a1. 128/218 3,276,632 10/1966 Stanzel 222/83.5 3,326,416 6/1967 Hayes 222/145X 3,354,883 1 H1967 Southerland 128/272X Primary Examiner- Richard A. Gaudet Assistant Examiner-Kyle L. Howell Atlorney- Rommel & Rommel ABSTRACT: A dual unit syringe capable of supporting a pluralit'y of isolated medicaments or pharmaceuticals separated one from the other under such circumstances that they will be maintained in stable form for long shelf life. The syringe has means using one liquid medicament and a cannula containing another and different liquid medicament under such circumstances that the medicaments can be mixed in and expelled from the cannula in blended form.
DUAL UNIT SYRINGE This invention relates to a dual unit syringe capable of supporting a plurality of isolated medicaments or pharmaceuticals. The medicaments are separated from one another under such circumstances that they will be maintained in stable form and properly packaged for long shelf life. The syringe parts are so associated that the medicaments can, with ease, at the time of intended use, be properly blended and applied.
The primary object of this invention is the provision of a dual unit syringe which is adapted to be used for admixing a plurality of pharmaceuticals, one of the pharmaceuticals being penicillin. Penicillin is sensitive to various bases and other drugs frequently necessary to be added thereto as a supplement. It is easily destroyed or degraded when compounded with other pharmaceuticals. it is necessary therefore to isolate penicillin and maintain it in a very stable form. Therefore, the dual unit syringe of this invention comprises means for isolating the penicillin under such circumstances that the syringe can be manipulated for expelling medicinal supplements into penicillin and applying the resultant mixture.
A further object of this invention is the provision of a dual unit syringe which consist of a main tubular body adapted to receive a pharmaceutical or pharmaceuticals, and having as sociated therewith a cannula adapted to isolate penicillin under such circumstances that at the time of use the pharmaceuticals of the tubular body may be expelled into and through the penicillin of the cannula and the resultant mixture applied as desired. I
A further object of this invention is the provision of a convenient and satisfactory means of packaging and maintaining a multiple dose syringe with medicinal ingredients thereof separated until desired to be used, and under such circumstances that the syringe may be operated to cause admixture of the ingredients and application at a desired time.
A further object of this invention is the provision of a dual unit syringe capable of handling a plurality of medicaments respectively isolated from each other within the syringe, and under such circumstances that they may be admixed at the proper time and applied. One such use would be infusing the mammary gland of a cow through the teat canal.
Other objects and advantages of this invention will be apparent during the course of the following detailed description, taken in connection with the accompanying drawing, forming portions of this specification, and in which drawing:
FIG. 1 is a side elevation of the assembled dual unit syringe.
FIG. 2 is a longitudinal cross-sectional view taken through the syringe showing the parts of the same ready for medicinal application.
FIG. 3 is a side elevation of a different form of dual unit syringe in which expulsion power is received from an aerosol container.
H6. 4 is a vertical cross-sectional view taken through a cannula adapted to isolate penicillin under such circumstances that it can be maintained for a prolonged shelf life prior to compounding.
FIG. 5 is a fragmentary view, partly in section, showing the upper end of a tubular body or container adapted to receive one or more pharmaceuticals.
FIG. 6 is a cross-sectional view taken on the line 6-6 of FIG. 2.
In the drawing, wherein for the purpose of illustration are shown different forms of the invention, and wherein similar reference characters designate corresponding parts throughout the several views, the letter A may generally designate the preferred form of invention and B a modification thereof. ln both forms of invention a cannula 10 is provided, which may be of any desirable material, preferably a synthetic plastic, It comprises an elongated tubular body 11 which at the upper end thereof tapers at 12 in an upward converging relation. It is provided withan applicator nozzle inserting stem or needle 13 of uniform diameter from end to end. The body 11 has a chamber 12 therein adapted to receive penicillin, or some other pharmaceutical which is intended to be expelled through the tapered passageway 14 of the neck 12 and then through the duct 15 of the applicator tube 13. A removable cap 16 normally seals the outer end of the nozzle 13. The tubular body 11 intermediate the ends thereof is provided with a rupturable membrane 20 adapted to seal off the chamber 12 for the purpose of isolating the body of penicillin 21 in liquid form. The tubular body 11 below the membrane 20 has a socket 22 and a base flange 23; the socket 22 being adapted to receive a tubular nozzle 25 at the outer or upper end of the syringe tubular body 30.
The tubular body 30 is preferably made of plastic and is of uniform diameter from end to end. It has a chamber 31 therein adapted to receive one or more supplemental medicaments. At its outer end it is provided with an end wall 32, upon which the nozzle 25 is mounted; a duct 34 extending through the wall 32 and the nozzle 25. The tubular body 30 at the lower end thereof is provided with laterally extending handle or finger flanges 36 as shown in the drawing. The chamber 31 is of uniform diameter from end to end and opens at the same diameter at the lower end of the tubular body 30. It is adapted to receive one or more supplemental pharmaceuticals, such as neomycin, dihydrostreptomycin, hydrocortisone or sulfonamides.
ln the form of invention A the means for expelling the liquid pharmaceuticals from the tubular body 30 into the cannula and through the medicament therein may comprise a single dose plunger or a plunger 40 which consists of a body formed of a plurality of radially extending flat flanges 60, connected centrally at 61. They are notched at 62 at the outer edges thereof. The upper ends of these flanges support a slidable plunger head 64 of flexible plastic or other suitable material. lt is adapted for insertion through the bottom opening of the chamber 31 and operates in leak-proof sliding relation in the chamber 31. The flanges 61 at the lower ends thereof support a palm engaging base or flange 66. A plunger limiting nut or ring 67 is threaded in the notches 62 having a segmental rib 68 thereon for such purpose. Rotation of the nut or ring 67 enables it to be properly located along the length of the plunger so as to permit a proper dosage of the amount of the medicament or combination of medicament 70 from ,the chamber 31 to be expelled into and through the cannula 10.
In the areosol type of syringe B, the cannula 10 is similar in structure to that above described. It also includes an aerosol container adapted to receiver the medicaments in liquified gas. The container 80 has an adapter cap 81 with a nozzle 25" similar to the nozzle 25 of the form of invention A and for the same purpose. The cap 81 is provided with an operating handle 82 which may be manipulated as by tilting, as with conventional aerosol syringes to release the medicament and gas from the container 80 for the admixture with penicillin as it passes through the cannula 10.
It will be noted in the form of invention A that the syringe barrel or tube 30 has a plunger adapted to divide the combination of medicaments 70 into four doses. As before stated, the plunger may provide for a single dose or a multiple dose. In the multiple dose the assembly should include a number of loaded cannulas 10 with the medicament 21 in amount equivalent to the number of doses. to be disbursed from chamber 31. The package as sold may comprise the equipment above described and with each syringe barrel there is provided four cannulas 10, each loaded with penicillin or some other medicament. The user can remove an empty cannula after administering one dose and continue using the same syringe barrel for the application of the remaining three doses.
Various changes in the size, shape and arrangement of parts may be made to the forms of invention herein shown and described, without departing from the spirit of the invention or the scope of the claims.
1. in a dual unit medicament dispensing syringe the combination of a tubular body having a chamber therein containing a liquid medicament and having a reduced top discharged nozzle provided with a passageway therethrough communicating with the chamber, the chamber at the lower end of said tudischarge passage communicatng with said cannula chamber, said cannula at is its opposite end from said applicator having a sealing disc disposed inwardly a sufiicient distance from said end to provide an opened ended socket receiving the nozzle of the tubular body, said socket being of such length that when the nozzle is fully inserted therein it will rupture the disc, and a removable sealing cap for the reduced end of said cannula.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2856925 *||Nov 25, 1957||Oct 21, 1958||Easton||Syringe structure|
|US3276632 *||Apr 2, 1965||Oct 4, 1966||Stanzel George A||Repellent fluid-dispensing weapon|
|US3326416 *||Jan 14, 1966||Jun 20, 1967||Du Pont||Apparatus for codispensing a plurality of liquids|
|US3354883 *||Mar 8, 1965||Nov 28, 1967||Lee Southerland Elizabeth||Disposable syringe having frangible means for mixing plural medicaments|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3789844 *||Sep 10, 1971||Feb 5, 1974||Burges A||Foil sealed syringe|
|US4275729 *||Oct 29, 1979||Jun 30, 1981||Jules Silver||Adjustable dosage syringe|
|US4723938 *||Dec 24, 1986||Feb 9, 1988||Schneider-Shiley (Usa) Inc.||Single plunger inflation device for angioplasty catheter|
|US4750373 *||Jan 22, 1987||Jun 14, 1988||Shapiro Justin J||Adjustable volume, pressure-generating pipette sampler|
|US4874385 *||Dec 16, 1987||Oct 17, 1989||Sherwood Medical Company||Plunger lock device|
|US5320845 *||Jan 6, 1993||Jun 14, 1994||Py Daniel C||Apparatus for delivering multiple medicaments to an eye without premixing in the apparatus|
|US5322800 *||Aug 13, 1993||Jun 21, 1994||The United States Of America As Represented By The Secretary Of The Interior||Method and device for safely preserving aqueous field samples using acid or base|
|US5328486 *||Nov 19, 1991||Jul 12, 1994||American Cyanamid Company||Syringe for dispensing multiple dosages|
|US5344409 *||Jun 14, 1993||Sep 6, 1994||Genesis Industries Inc.||Syringe latch|
|US5501373 *||Jul 30, 1992||Mar 26, 1996||R.G.S.A.S.Di Rosaria Galli & C||Atomizing dispenser for endonasal drug spray administration|
|US5522804 *||Apr 22, 1994||Jun 4, 1996||Lynn; Lawrence A.||Aspiration, mixing, and injection syringe|
|US5531708 *||Jul 1, 1994||Jul 2, 1996||American Cyanamid Company||Syringe for dispensing multiple dosages|
|US5549569 *||Mar 30, 1995||Aug 27, 1996||Lawrence A. Lynn||Ex vivo blood isolation system|
|US5613957 *||Mar 11, 1994||Mar 25, 1997||Daniel Py||Apparatus for applying medicament to an eye|
|US5643218 *||Aug 20, 1996||Jul 1, 1997||Lawrence A. Lynn||Auto-flushing medical fluid injection system|
|US5685869 *||May 2, 1995||Nov 11, 1997||Daniel Py||Apparatus for applying medicament to an eye|
|US5697915 *||May 30, 1996||Dec 16, 1997||Lynn; Lawrence A.||Displacement-activated medical check valve|
|US5743886 *||Aug 20, 1996||Apr 28, 1998||Lawrence A. Lynn||Sequential medical fluid aspiration and injection system and method|
|US5769825 *||Aug 20, 1996||Jun 23, 1998||Lynn; Lawrence A.||Self-contained syringe and pharmaceutical packaging system for enclosed mixing of pharmaceutical and diluent|
|US5811061 *||Jul 25, 1996||Sep 22, 1998||Baxter International Inc.||Method and device for testing blood units for viral contamination|
|US5944702 *||Sep 11, 1997||Aug 31, 1999||Instill & Co.||Method for instilling a predetermined volume of medicament into an eye|
|US6228065||Jun 22, 1998||May 8, 2001||Lawrence A. Lynn||Displacement activated medical check valve|
|US6312413 *||Oct 21, 1998||Nov 6, 2001||Novo Nordisk A/S||Cylinder ampoule|
|US6562007||Sep 28, 2000||May 13, 2003||Bayer Healthcare Llc||Adjustable dosage syringe|
|US6981963||Mar 13, 2002||Jan 3, 2006||Mdc Investment Holdings, Inc.||Pre-filled safety diluent injector|
|US7159490 *||Mar 24, 2006||Jan 9, 2007||Ragan Philip J||Bottle injector|
|US7261704||Dec 26, 2002||Aug 28, 2007||Terumo Kabushiki Kaisha||Syringe|
|US7427276||Jul 20, 2007||Sep 23, 2008||Terumo Kabushiki Kaisha||Syringe|
|US7470259||Mar 24, 2006||Dec 30, 2008||Hoyle Jr John D||Dosage control syringe|
|US7753890 *||Jul 13, 2010||Dragon Drug Gun, Inc.||Multiple drug injection apparatus|
|US7935086 *||May 3, 2011||L M M Global Innovations, Inc.||Multiple drug injection apparatus|
|US8021343 *||Sep 20, 2011||Medical Components, Inc.||Syringe for sequential expression of different liquids|
|US8021349||Jan 29, 2010||Sep 20, 2011||Medical Components, Inc.||Method of using a syringe|
|US8287491||Nov 25, 2009||Oct 16, 2012||Becton, Dickinson And Company||Single-use auto-disable syringe|
|US8771234||Jul 6, 2011||Jul 8, 2014||Medical Components, Inc.||Syringe for sequential expression of different liquids|
|US8771254||Jul 12, 2011||Jul 8, 2014||Medical Components, Inc.||Method of using a syringe|
|US9089648||Jun 1, 2010||Jul 28, 2015||Sanofi-Aventis Deutschland Gmbh||Medicated module with premix medicament|
|US9089649||Jun 1, 2010||Jul 28, 2015||Sanofi-Aventis Detuschland Gmbh||Medicated module for a drug delivery device|
|US9205205||Sep 14, 2012||Dec 8, 2015||Becton, Dickinson And Company||Single-use auto-disable syringe|
|US20020177805 *||Mar 13, 2002||Nov 28, 2002||Barker John M.||Pre-filled safety diluent injector|
|US20050131354 *||Dec 26, 2002||Jun 16, 2005||Terumo Kabushiki Kaisha||Syringe|
|US20050215957 *||Mar 26, 2004||Sep 29, 2005||Mallinckrodt Inc.||Calibrated pushrod for injection volume control in prefilled syringes|
|US20060162501 *||Mar 24, 2006||Jul 27, 2006||Ragan Philip J||Bottle injector|
|US20070225656 *||Mar 24, 2006||Sep 27, 2007||Hoyle John D Jr||Dosage Control Syringe|
|US20070265580 *||Jul 20, 2007||Nov 15, 2007||Terumo Kabushiki Kaisha||Syringe|
|US20080114304 *||Nov 9, 2007||May 15, 2008||Medical Components, Inc||Syringe for sequential expression of different liquids and method of using same|
|US20080142554 *||Dec 14, 2006||Jun 19, 2008||John Lafferty||Multiple Drug Injection Apparatus|
|US20080171996 *||Jun 17, 2007||Jul 17, 2008||John Peter Lafferty||Multiple Drug Injection Apparatus|
|US20100152668 *||Jan 29, 2010||Jun 17, 2010||Medical Components, Inc||Method of Using a Syringe|
|US20100174236 *||Nov 25, 2009||Jul 8, 2010||Steven Burns||Single-use auto-disable syringe|
|US20120136334 *||Jun 1, 2010||May 31, 2012||Sanofi-Aventis Deutschland Gmbh||Delivery of Two or More Medicaments Through a Single Dose Selection and Dispense Interface|
|USRE37047||Dec 5, 1995||Feb 6, 2001||Daniel Py||Cartridge for applying medicament to an eye from a dispenser|
|CN102458531A *||Jun 1, 2010||May 16, 2012||赛诺菲-安万特德国有限公司||Delivery of two or more medicaments through a single dose selection and dispense interface|
|CN102458531B||Jun 1, 2010||Aug 20, 2014||赛诺菲-安万特德国有限公司||Delivery of two or more medicaments through a single dose selection and dispense interface|
|CN102858395A *||Mar 23, 2011||Jan 2, 2013||赛诺菲-安万特德国有限公司||Dedicated needle assembly|
|CN102858395B *||Mar 23, 2011||Apr 22, 2015||赛诺菲-安万特德国有限公司||Dedicated needle assembly|
|DE2753609A1 *||Dec 1, 1977||Jan 4, 1979||Silver Jules||Injektionsspritze|
|EP0022987A1 *||Jul 10, 1980||Jan 28, 1981||Cutter Laboratories, Inc.||Syringe|
|EP0493639A1||Dec 31, 1990||Jul 8, 1992||Jules Dr. Silver||Syringe for dispensing measured quantities of a material|
|EP2094336A2 *||Nov 9, 2007||Sep 2, 2009||Medical Components, Inc.||Syringe for sequential expression of different liquids and method of using same|
|WO1981001104A1 *||Oct 29, 1980||Apr 30, 1981||J Silver||Adjustable dosage syringe|
|WO1999007421A1 *||Aug 8, 1997||Feb 18, 1999||Genesis Industries Incorporated||Incrementally adjustable dose syringe|
|WO2002026298A2||Sep 24, 2001||Apr 4, 2002||Bayer Healthcare Llc||Adjustable dosage syringe|
|WO2003057288A1 *||Dec 26, 2002||Jul 17, 2003||Terumo Kabushiki Kaisha||Pre-filled syringe|
|WO2010139666A1 *||Jun 1, 2010||Dec 9, 2010||Sanofi-Aventis Deutschland Gmbh||Delivery of two or more medicaments through a single dose selection and dispense interface|
|WO2010139669A1 *||Jun 1, 2010||Dec 9, 2010||Sanofi-Aventis Deutschland Gmbh||Medicated module with premix medicament|
|WO2010139670A1 *||Jun 1, 2010||Dec 9, 2010||Sanofi-Aventis Deutschland Gmbh||Medicated module for a drug delivery device|
|WO2011040900A1 *||Nov 13, 2009||Apr 7, 2011||Salzman Marc J||Syringe-attached topical anesthetic dispenser|
|WO2011117282A1 *||Mar 23, 2011||Sep 29, 2011||Sanofi-Aventis Deutschland Gmbh||Dedicated needle assembly|
|U.S. Classification||604/87, 604/211|
|International Classification||A61M3/00, A61M5/315|
|Cooperative Classification||A61M5/31551, A61M5/31596, A61M5/31561, A61M3/005, A61M5/31591|
|European Classification||A61M5/315E2B1A, A61M5/315F3A, A61M5/315M, A61M3/00M|
|Mar 13, 1981||AS04||License|
Owner name: HARTFORD NATIONAL BANK AND TRUT COMPANY (A NATIONA
Owner name: SILVER INDUSTRIES, INC., ONE WISCONSIN AVE., NORWI
Effective date: 19801119
|Mar 13, 1981||AS06||Security interest|
Owner name: HARTFORD NATIONAL BANK AND TRUST COMPANY, 777 MAIN
Effective date: 19801119
Owner name: SILVER INDUSTRIES, INC., A CORP. OF CT.
|Mar 13, 1981||AS||Assignment|
Owner name: HARTFORD NATIONAL BANK AND TRUST COMPANY, 777 MAIN
Free format text: SECURITY INTEREST;ASSIGNOR:SILVER INDUSTRIES, INC., A CORP. OF CT.;REEL/FRAME:003844/0146
Owner name: SILVER INDUSTRIES, INC., ONE WISCONSIN AVE., NORWI
Free format text: LICENSE;ASSIGNOR:HARTFORD NATIONAL BANK AND TRUT COMPANY (A NATIONAL BANKING ASSOCIATION);REEL/FRAME:003844/0153
Effective date: 19801119
|Sep 2, 1980||AS02||Assignment of assignor's interest|
Owner name: SILVER INDUSTRIES, INC., ONE WISCONSIN AVE.,NORWIC
Owner name: SILVER, JULES
Effective date: 19800609