|Publication number||US3563415 A|
|Publication date||Feb 16, 1971|
|Filing date||Jun 4, 1969|
|Priority date||Jun 4, 1969|
|Publication number||US 3563415 A, US 3563415A, US-A-3563415, US3563415 A, US3563415A|
|Inventors||Ogle Robert W|
|Original Assignee||Multi Drop Adapter Corp|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (7), Referenced by (80), Classifications (16)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent Primary Examiner-Samuel F. Coleman Assistant Examiner-Norman L. Stack, Jr. Attorney-Finkelstein and Mueth ABSTRACT: A multidrop adapter or dispenser in which a tubular member which may have an enlarged head for containing a powder or substance to be mixed with a liquid in the remainder of the tubular member is telescopically received in a second tubular member which seals one end of a piston which extends into the first tubular member and has a bore which extends out of said second tubular member to expel a drop of liquid when said first tubular :member is telescopically moved into said second tubular member and over said piston; and resilient means biasing said first tubular member out of said second tubular member. A plug in said first tubular member is dispelled into said enlarged head upon movement of said first tubular member over said piston when said enlarged head is employed in the invention.
PATENTED m1 6l97| SHEET 1 BF 2 INVENTOR 605667- W. 0646 a ax Arrow/6V5 MUL'IIDROP ADAPTER BACKGROUND OF INVENTION Devices for dispensing repeated drops of medicine or other liquids for a variety of purposes are of great antiquity hence the man skilled in the art hasa wealth of historic development from which to draw. Perhaps the simplest such device constitutes a mere short length of tubing, such as a straw, which can be filled or partially filled with water or other liquid and drops dispensed by alternately placing and removing a finger from the upper end of such an inverted straw. The eyedropper with its squeezable rubber bulb affixed to a glass tubing dispenser is a familiar occupant of nearly every medicine cabinet. Nevertheless, when it is desired for example, to give a vaccination by applying a drop of vaccine over an opened portion of the skin of a patient it is still common practice to resort to a syringe or other costly or complicated device for dispensing the single drop of vaccine required. More particularly, the problem becomes compounded when the liquid to be dispensed is one which must be made up just before it is dispensed, as for example, where a powder is mixed with a liquid just before application or where two liquids which are not compatible over any extended period of time are to be mixed just prior to application.
Accordingly, it is one object of the present invention to provide a multidrop adapter which retains the traditional simplicity of such devices and yet is capable of dispensing a plurality of carefully measured single drops of liquid,which may be in one of the embodiments of this invention a liquid which has just been constituted, in situ, by mixing together a powder and a liquid or two liquids just prior to their use.
These and other objects and advantages of this invention will be apparent from the more detailed description which follows.
DESCRIPTION OF PREFERRED EMBODIMENTS Turning to the drawings:
FIG. I is a sectional view of a preferred embodiment of the present invention;
FIG. 2 is a view similar to FIG. 1 showing the plug after displacement;
FIG. 3 is a view similar to FIGS. 1 and 2 after a complete depressing of the cylinder and the formation of a drop of liquid about to be released; I
FIG. 4 is a vertical section of the device illustrated in FIG. 1 and taken along the line 4-4;
FIG. 5 is a perspective view of a preferred form of resilient means utilized in the present invention;
FIG. 6 is a vertical section of another embodiment of the invention;
FIG. 7 is a vertical section of a further embodiment of the invention; and
FIG. 8 is a vertical section of the device shown in FIG. 7 in a fully depressed condition of the cylinder.
Referring now more particularly to the drawings, there is illustrated a multidrop adapter in the preferred embodiment of which there is utilized a device 10 which is termed herein a cylinder because it receives a plug 11 and a piston 12 but which has an enlarged, hollow head 13 as illustrated. The plug 11 normally fits in the cylinder 10 as indicated in FIG. I but is displaced into the head 13 prior to the dispensing of a drop of liquid as hereinafter described.
Head I3 is normally partially filled with a dry substance or powder 14 but the number 14 can be taken to illustrate a liquid other than the liquid 15 which fills the space between the piston I2 and the plug 11.
The remaining parts constituting the preferred embodiment are the applicator l6 and the compression pad 17.
The applicator I6 is in the form of a cylinder having a flange 18 and an annular skirt I9 the interior of which cylinder receives in sliding fit the exterior of the cylinder 10.
Piston 12 is generally in the form of a solid flexible member of rubber or rubberlike material having a longitudinal central passage or bore 20. A nose 21 of reduced cross section, and an enlarged upper end 22 having a pair ofspaced sealing rings 23 and 24 formed thereon and adapted to sealingly engage the exterior of the cylinder 10. The tapered underside 25 of end 22 is cemented or glued to inner cylinder 26 by joining material 27 so that piston 12 is effectively held in place during operation of the device.
The compression pad 17 is preferably made of rubber and has the form of a ring with three downturned legs 28 which in use rest upon the bottom of applicator 16 in the annular space between the outer wall of applicator I6 and cylinder 26.
For storage, the device may be provided with a cap 29 which seals on both skirt l9 and nose 21 to maintain sterility. The cap is removed prior to operation of the device.
The operation of the above-described device is as follows: Assuming the device illustrated to be filled with a liquid 15 between the plug 11 and the piston 12 and a powder 14in the head 13. The device is held in an upright position with the head 13 low and the nose 21 high. In this position a collapsing of the device by pressing the cylinder 10 into the applicator l6 and over the piston I2 will cause the plug 11 to be blown into the head 13 as indicated in FIG. 2. In this condition the liquid 15 may mix with the powder 14 (or two liquids may mix). Thereafter, the device is inverted, the nose 21 is pointed at the spot where a drop of liquid 30 is desired and the device is further collapsed to the condition shown in FIG. 3 in which the end of cylinder 10 contacts the ring portion of pad 17, collapses the legs 28 thereof and forces a drop or bead of liquid 30 to fall from the nose 21. Thereafter, the head 13 may be released and the device will return to its original expanded condition, with the plug 11, however, still in head 13, under the force of the resilience of the legs 28 of pad 17. The return of the device to the expanded position draws air into the head 13 through bore 20 to permit the forming of a succeeding drop.
Referring now more particularly to FIG. 6, there is shown an embodiment of the invention wherein the cylinder 31 differs from the cylinder 10 by not having an enlarged head 13 and by having a closed end 32 instead of a plug 11. Obviously, this device merely dispenses a drop of liquid and does not perform any mixing function. All of the remaining parts are identical with those of the previous embodiment.
Turning now to FIGS. 7 and 8, there is shown a further embodiment of the invention wherein a cylinder 33 has a plug 34, a piston 35 and an enlarged head 36 generally comparable to the correlative numbers 10--I3 of the first embodiment. An applicator 37 similar to the applicator 116 has a flange 38 and a reduced hub 39. The applicator 37 includes an integral upstanding cylindrical portion 40 preferably formed integrally with the remainder of the applicator 37 and spaced inwardly from the sidewall of the applicator to leave an annular space 41. A coil spring 42 surrounds the member 40 in the annular space 41 and has its upper end engaging the flange 43 of a member 44. Member 44 is preferably formed of plastic and is a cylindrical sleeve adapted to fit over the upstanding member 7 40 and have its flange 43 also engaged by the end of the cylinder 33 as clearly shown in FIGS. 7 and 8. The upstanding member 40 may be internally threaded as at 49 to receive the external threads 45 of a rubber piston 35 threaded therein as indicated. A tube 46 is cemented in the bore 47 of the hub 39 and extends upwardly within the member 40 and into the bore 48 of piston 35 as shown.
The operation of the device shown in FIGS. 7 and 8 is identical with that of FIGS. 1-6 with the coil spring 42 I claim:
1. A multidrop dispenser comprising:
a first tubular member having an open end and a closed end;
a second tubular member having an open end and a partially closed end, said first tubular member being telescopically slidable in said second tubular member;
a piston in said first tubular member and having a portion extending into and through the partially closed end of said second tubular member;
a central bore in said piston; and
resilient means having extended and collapsed positions carried by said second tubular member and adapted to engage said first tubular member and biasing said first tubular member towards extended rather than collapsed position of said resilient means.
2. A multidrop dispenser as set forth in claim 1 in which said first tubular member is provided with an enlarged head and a stopper adapted to be forced into said enlarged head upon partial telescopic movement of said first tubular member into said second tubular member.
3. A multidrop dispenser as set forth in claim 1 in which said piston terminates in a nose upon which a bead, a drop, of liquid is formed upon expulsion of such liquid from said first tubular member through said bore by telescopic movement of said first tubular member into said second tubular member and over said piston.
4. A multidrop dispenser as set forth in claim 2 in which said piston terminates in a nose upon which a bead, a drop, of liquid is formed upon expulsion of such liquid from said first tubular member through said bore by telescopic movement of said first tubular member into said second tubular member and over said piston.
5. A multidrop dispenser as set forth in claim 1 in which said resilient means comprises a rubberlike ring member adapted to be compressed upon movement of said first tubular member into said second tubular member.
6. A multidrop dispenser as set forth in claim 2 in which said resilient means comprises a rubberlike ring member adapted to be compressed upon movement of said first tubular member into said second tubular member.
7. A multidrop dispenser as set forth in claim 3 in which said resilient means comprises a rubberlike ring member adapted to be compressed upon movement of said first tubular member into said second tubular member.
8. A multidrop dispenser as set forth in claim 1 in which said resilient means comprises a coil spring seated in said second tubular member and adapted to engage the partially closed end thereof at one end and the inner end of said first tubular member at the other end thereof.
9. A multidrop dispenser as set forth in claim 2 in which said resilient means comprises a coil spring seated in said second tubular member and adapted to engage the partially closed end thereof at one end and the inner end of said first tubular member at the other end thereof.
10. A multidrop dispenser as set forth in claim 4 in which said resilient means comprises a coil spring seated in said second tubular member and adapted to engage the partially closed end thereof at one end and the inner end of said first tubular member at the other end thereof.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US487732 *||Apr 5, 1892||Dec 13, 1892||Watch-oiler|
|US2695614 *||Dec 10, 1952||Nov 30, 1954||Compule Corp||Plural-compartment admixing vial|
|US2773591 *||Oct 15, 1953||Dec 11, 1956||Novo Terapeutisk Labor As||Vessel with sterile closure for separate storage of at least two substances|
|US3187960 *||May 8, 1964||Jun 8, 1965||Sterling Drug Inc||Non-metallic pump dispenser|
|US3370754 *||Dec 21, 1966||Feb 27, 1968||Products Res & Chemical Corp||Syringe for mixing and dispensing two ingredients|
|US3494359 *||Mar 17, 1969||Feb 10, 1970||Silver Jules||Two compartment syringe with a single barrel|
|US3514017 *||Mar 3, 1969||May 26, 1970||Afa Corp||Pressure regulating structure for piston pump|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3788528 *||Aug 23, 1971||Jan 29, 1974||Ims Ltd||Mini dropper|
|US3968872 *||Aug 2, 1974||Jul 13, 1976||Sigma-Tau||Device, provided with a puncher and a dripper, for the hermetic sealing of containers|
|US4142656 *||Dec 17, 1976||Mar 6, 1979||Eastman Kodak Company||Drop former utilizing gas pressure|
|US4657534 *||Nov 4, 1985||Apr 14, 1987||Alcon Laboratories, Inc.||Dual compartment, disposable, mixing and dispensing container|
|US4741737 *||Oct 2, 1986||May 3, 1988||Medicorp Holding S.A.||Prefilled ampoule-syringe|
|US4776704 *||Dec 15, 1986||Oct 11, 1988||Dentsply Research & Development Corp.||Mixing and dispensing syringe|
|US4941876 *||Mar 23, 1987||Jul 17, 1990||Medicorp Holding S.A.||Device for conditioning liquids or liquid and solid substances|
|US4979941 *||Dec 5, 1989||Dec 25, 1990||International Medication Systems, Limited||Device suitable for mixing medication|
|US5114411 *||Nov 19, 1990||May 19, 1992||Habley Medical Technology Corporation||Multi-chamber vial|
|US5169388 *||Jun 7, 1990||Dec 8, 1992||Gensia Pharmaceuticals, Inc.||Pressure-activated medication dispenser|
|US5176634 *||Aug 2, 1990||Jan 5, 1993||Mcgaw, Inc.||Flexible multiple compartment drug container|
|US5267986 *||Apr 6, 1992||Dec 7, 1993||Self-Instill & Co., Inc.||Cartridge for applying medicament to an eye from a dispenser|
|US5330048 *||Jul 9, 1993||Jul 19, 1994||Habley Medical Technology Corporation||Controlled access mixing vial|
|US5401259 *||Oct 6, 1993||Mar 28, 1995||Py Daniel C||Cartridge for applying medicament to an eye|
|US5478324 *||Feb 18, 1994||Dec 26, 1995||Medicorp Holding S.A.||Prefilled syringe for storing and for transfer of liquid and sterile medicinal substances|
|US5487737 *||Oct 18, 1993||Jan 30, 1996||Becton, Dickinson And Company||Storage and transfer bottle designed for storing a component of a medicamental substance|
|US5526853 *||Aug 17, 1994||Jun 18, 1996||Mcgaw, Inc.||Pressure-activated medication transfer system|
|US5533994 *||Oct 18, 1993||Jul 9, 1996||Becton Dickinson France S.A.||Storage and transfer bottle designed for storing two components of a medicamental substance|
|US5613957 *||Mar 11, 1994||Mar 25, 1997||Daniel Py||Apparatus for applying medicament to an eye|
|US5641010 *||Jun 2, 1995||Jun 24, 1997||International Medication Systems, Limited||Mixing and dispensing apparatus|
|US5685869 *||May 2, 1995||Nov 11, 1997||Daniel Py||Apparatus for applying medicament to an eye|
|US5944702 *||Sep 11, 1997||Aug 31, 1999||Instill & Co.||Method for instilling a predetermined volume of medicament into an eye|
|US6213597 *||Feb 29, 2000||Apr 10, 2001||Win-Yin Liu||Apparatus for ink cartridge of a jet printer|
|US6427682||Jan 14, 2000||Aug 6, 2002||Aerogen, Inc.||Methods and apparatus for aerosolizing a substance|
|US6719729 *||Nov 8, 2001||Apr 13, 2004||Dentaco Dentalindustrie Und-Marketing Gmbh||Prefilled telescoping multiple chamber ampoule device|
|US6978941||Apr 9, 2004||Dec 27, 2005||Aerogen, Inc.||Base isolated nebulizing device and methods|
|US7032590||Jan 5, 2004||Apr 25, 2006||Aerogen, Inc.||Fluid filled ampoules and methods for their use in aerosolizers|
|US7040549||Mar 21, 2003||May 9, 2006||Aerogen, Inc.||Systems and methods for controlling fluid feed to an aerosol generator|
|US7066398||Mar 30, 2001||Jun 27, 2006||Aerogen, Inc.||Aperture plate and methods for its construction and use|
|US7104463||Oct 6, 2005||Sep 12, 2006||Aerogen, Inc.||Base isolated nebulizing device and methods|
|US7174888||Sep 5, 2003||Feb 13, 2007||Aerogen, Inc.||Liquid dispensing apparatus and methods|
|US7195011||Jun 30, 2004||Mar 27, 2007||Aerogen, Inc.||Convertible fluid feed system with comformable reservoir and methods|
|US7201167||Mar 14, 2005||Apr 10, 2007||Aerogen, Inc.||Method and composition for the treatment of lung surfactant deficiency or dysfunction|
|US7207970 *||Jun 25, 2004||Apr 24, 2007||Nipro Corporation||Displaceable-plug-containing filling/discharging port and medical container having the same|
|US7267121||Sep 30, 2004||Sep 11, 2007||Aerogen, Inc.||Aerosol delivery apparatus and method for pressure-assisted breathing systems|
|US7290541||Jun 30, 2004||Nov 6, 2007||Aerogen, Inc.||Aerosol delivery apparatus and method for pressure-assisted breathing systems|
|US7322349||Jun 18, 2003||Jan 29, 2008||Aerogen, Inc.||Apparatus and methods for the delivery of medicaments to the respiratory system|
|US7331339||Nov 23, 2004||Feb 19, 2008||Aerogen, Inc.||Methods and systems for operating an aerosol generator|
|US7360536||Jan 7, 2003||Apr 22, 2008||Aerogen, Inc.||Devices and methods for nebulizing fluids for inhalation|
|US7600511||Oct 30, 2002||Oct 13, 2009||Novartis Pharma Ag||Apparatus and methods for delivery of medicament to a respiratory system|
|US7628339||May 5, 2006||Dec 8, 2009||Novartis Pharma Ag||Systems and methods for controlling fluid feed to an aerosol generator|
|US7677467||Apr 20, 2005||Mar 16, 2010||Novartis Pharma Ag||Methods and devices for aerosolizing medicament|
|US7748377||Oct 30, 2007||Jul 6, 2010||Novartis Ag||Methods and systems for operating an aerosol generator|
|US7771642||Apr 1, 2005||Aug 10, 2010||Novartis Ag||Methods of making an apparatus for providing aerosol for medical treatment|
|US7861897 *||Oct 31, 2006||Jan 4, 2011||Dentaco Dentalindustrie-Und Marketing Gmbh||Applicator device|
|US7946291||Apr 20, 2004||May 24, 2011||Novartis Ag||Ventilation systems and methods employing aerosol generators|
|US7971588||Mar 24, 2005||Jul 5, 2011||Novartis Ag||Methods and systems for operating an aerosol generator|
|US8196573||Jan 23, 2008||Jun 12, 2012||Novartis Ag||Methods and systems for operating an aerosol generator|
|US8235953 *||May 16, 2006||Aug 7, 2012||Robert Bosch Gmbh||Metering device and method for operating same|
|US8336545||Jan 16, 2007||Dec 25, 2012||Novartis Pharma Ag||Methods and systems for operating an aerosol generator|
|US8398001||Jun 19, 2006||Mar 19, 2013||Novartis Ag||Aperture plate and methods for its construction and use|
|US8539944||Apr 8, 2008||Sep 24, 2013||Novartis Ag||Devices and methods for nebulizing fluids for inhalation|
|US8561604||Feb 12, 2007||Oct 22, 2013||Novartis Ag||Liquid dispensing apparatus and methods|
|US8616195||Apr 27, 2004||Dec 31, 2013||Novartis Ag||Nebuliser for the production of aerosolized medication|
|US8647114 *||Nov 17, 2008||Feb 11, 2014||Dispensys Ag||Apparatus for applying a powdery or liquid material|
|US8728986||Jun 14, 2012||May 20, 2014||Robert Bosch Gmbh||Metering device and method for operating same|
|US9108211||Apr 17, 2006||Aug 18, 2015||Nektar Therapeutics||Vibration systems and methods|
|US20010013554 *||Mar 30, 2001||Aug 16, 2001||Scott Borland||Aperture plate and methods for its construction and use|
|US20040188534 *||Apr 9, 2004||Sep 30, 2004||Aerogen, Inc.||Base isolated nebulizing device and methods|
|US20040256488 *||Jun 30, 2004||Dec 23, 2004||Aerogen, Inc.||Convertible fluid feed system with comformable reservoir and methods|
|US20050011514 *||Apr 27, 2004||Jan 20, 2005||Aerogen, Inc.||Nebuliser for the production of aerosolized medication|
|US20050075613 *||Jun 25, 2004||Apr 7, 2005||Mitsuru Hasegawa||Displaceable-plug-containing filling/discharging port and medical container having the same|
|US20050172954 *||Nov 23, 2004||Aug 11, 2005||Aerogen Inc.||Methods and systems for operating an aerosol generator|
|US20050178847 *||Apr 1, 2005||Aug 18, 2005||Aerogen, Inc.||Methods of making an apparatus for providing aerosol for medical treatment|
|US20050199236 *||Apr 20, 2005||Sep 15, 2005||Aerogen, Inc.||Methods and devices for aerosolizing medicament|
|US20050205089 *||Jan 19, 2005||Sep 22, 2005||Aerogen, Inc.||Methods and devices for aerosolizing medicament|
|US20050217666 *||Mar 24, 2005||Oct 6, 2005||Aerogen, Inc.||Methods and systems for operating an aerosol generator|
|US20050229926 *||Mar 14, 2005||Oct 20, 2005||Aerogen, Inc.||Method and composition for the treatment of lung surfactant deficiency or dysfunction|
|US20050229928 *||Jun 30, 2004||Oct 20, 2005||Aerogen, Inc.||Aerosol delivery apparatus and method for pressure-assisted breathing systems|
|US20060264817 *||May 16, 2006||Nov 23, 2006||Thomas Brinz||Metering device and method for operating same|
|US20070023547 *||Jun 19, 2006||Feb 1, 2007||Aerogen, Inc.||Aperture plate and methods for its construction and use|
|US20070044792 *||Aug 30, 2005||Mar 1, 2007||Aerogen, Inc.||Aerosol generators with enhanced corrosion resistance|
|US20100248179 *||Nov 17, 2008||Sep 30, 2010||Sogaro Alberto C||Apparatus for applying a powdery or liquid material|
|USRE37047 *||Dec 5, 1995||Feb 6, 2001||Daniel Py||Cartridge for applying medicament to an eye from a dispenser|
|EP0431779A1 *||Nov 16, 1990||Jun 12, 1991||International Medication Systems Ltd||Device suitable for mixing medication|
|EP1464409A2 *||Mar 31, 2004||Oct 6, 2004||Ing. Erich Pfeiffer Gmbh||Device for discharging at least one fluid|
|WO1990007318A1 *||Dec 27, 1989||Jul 12, 1990||Medicorp Holding||Storage and transfer bottle designed for storing a component of a medicamental substance|
|WO1990007319A1 *||Dec 27, 1989||Jul 12, 1990||Medicorp Holding||Storage and transfer bottle designed for storing two components of a medicamental substance|
|WO2001051110A1 *||Jan 9, 2001||Jul 19, 2001||Aerogen Inc||Methods and apparatus for aerosolizing a substance|
|WO2006025902A1 *||May 31, 2005||Mar 9, 2006||Allergan Inc||Botox® needle injector|
|U.S. Classification||222/145.4, 604/198, 222/420, 604/231, 604/90|
|International Classification||A61M5/24, A61J1/00, A61J1/14, A61J1/20|
|Cooperative Classification||A61J2001/2044, A61J1/2093, A61M5/2448, A61M5/2429, A61J2001/2041|
|European Classification||A61M5/24E2, A61J1/20D|