|Publication number||US3574865 A|
|Publication date||Apr 13, 1971|
|Filing date||Aug 8, 1968|
|Priority date||Aug 8, 1968|
|Publication number||US 3574865 A, US 3574865A, US-A-3574865, US3574865 A, US3574865A|
|Inventors||Hamaker Ronald C|
|Original Assignee||Michigan Instr Inc|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (4), Non-Patent Citations (1), Referenced by (174), Classifications (8)|
|External Links: USPTO, USPTO Assignment, Espacenet|
States atent  lnventor Ronald C. Hamaker Royal Oak, Mich.
[211 Appl. No. 751,210
[22} Filed Aug. 8, 1968  Patented Apr. 13, 1971 [7 3] Assignee Michigan Instruments, Inc.
Grand Rapids, Mich.
[541 PROSTHETIC SUTURELESS HEART VALVE 8 Claims, 8 Drawing Figs.
 U.S. Cl 3/1, 128/303  lnt.Cl A6lf 1/22  Field of Search 128/334, 303; 3/1 (HV); 251/149.1
 References Cited UNITED STATES PATENTS 3,130,419 4/1964 Edwards 3/1 3,416,159 12/1968 Smeloffet a1 3/1 FORElGN PATENTS 1,180,087 10/1964 Germany 3/1l-lV 180,750 9/1966 U.S.S.R. 3/1HV OTHER REFERENCES Beall Mitral Valve Prosthesis" Surgitool Inc.
Advertisement, The Journal of Thoracic & Cardiovascular Surgery, Vol. 55, No. 2, Feb. 1968, Advertising Page 27. 3- ll-lV Primary Examiner-Richard A. Gaudet Assistant ExaminerRonald L. Frinks Att0rney-Price, l-leneveld, Huizenga and Cooper ABSTRACT: This disclosure relates to a prosthetic sutureless heart valve wherein a two-piece snapring is employed in fastening the valve to the heart. The valve has an annular base which contains a check valve and a plurality of pins which pierce the tissue around the valve. The annular snapring fits into the base near the pins to hold the valve and the tissue intact. A smooth, continuous surface is provided for passage of the blood through the valve.
Patent ed April 13, m1
2 Sheets-Sheet 1 INVENTOR Romp c. HAHAKER BY ,u' MI ATTORNEYS Patented A ril 13, 1971 3,574,865-
2 Sheets-Shut 2 INVENTOR RONALD C. HAMAKER I Y BY PaQMMW /W ATTOR NEYS PROSTIIETIC SUTURELESS HEART VALVE This invention relates to sutureless heart valves. In one of its aspects it relates to a sutureless heart valve containing an annular shaped base member having a central aperture with a check valve in the aperture, upwardly projecting pins on the base member spaced about the outer portion thereof, an annular snapring having a diameter sufficient to fit over the projecting pins, and means to provide a snap fit between said snapring and said base members, the snapring and the base being so shaped as to form a smooth, continuous surface through the central aperture and through the snapring.
In another of its aspects, the invention relates to a sutureless heart valve as has been hereinbefore described, wherein the check valve is a ball valve, a lenticular valve, or a leaflet valve.
It is not too uncommon to replace a heart valve with a permanent mechanical valve. The original development of these prosthetic valves was directed to sewing the valve into the heart tissue. This method, while being suitable in some instances, is a relatively long process which requires an extended period of cardiopulmonary bypass and protection of the heart by coronary profusion or reduced temperatures. It is highly desirable to have the valve placed in the heart as quickly as possible without suturing.
Cromie, U.S. Pat. No. 3,l43,742 discloses a prosthetic sutureless heart valve in which an upper and lower ring contain curved pins which project radially therefrom. A central ring is provided to squeeze the two rings together and cause the pins to rotate about a traverse axis to pierce the tissue surrounding the valve and thereafter lock the tissue in engagement with the valve.
The circulatory system is very delicate and important part of the body. If restrictions or rough surfaces appear within the circulatory system, blood clots can sometimes result. In the arteries and veins and other passageways through which blood flows. it is desirable to provide as smooth as possible a surface in order to avoid turbulent flow which is conducive to formation of blood clots. Thus, in the construction of heart valves, the surface over which the blood flows should be a relatively continuous and smooth surface.
I have now discovered a sutureless heart valve which can be rapidly installed in a heart and which, when assembled, has a smooth, continuous, inner surface through which the blood can flow.
By various aspects of this invention, one or more of the following, or other, objects can be obtained.
It is an object of this invention to provide a sutureless heart valve which can be quickly installed in a heart passage.
It is a further object of this invention to provide a prosthetic heart valve having a smooth, internal surface to minimize the possibility of turbulent flow of blood through the valves.
It is a still further object of this invention to provide a sutureless prosthetic heart valve having a smooth and continuous inner surface to minimize the traumatic effects of prosthetic valves on the circulatory system.
Other aspects, objects, and the several advantages of this invention are apparent to one skilled in the art from a study of this disclosure, the drawings, and the appended claims.
According to the invention there is provided a two-piece prosthetic sutureless heart valve. The valve contains an annular shaped base member having a central aperture with a smooth inner surface and with a check valve positioned therein. The valve also has pins projecting axially of the valve axis on the base and spaced about the outer portion thereof. Tissue is locked into the base structure by an annular shaped snapring which has a diameter sufficient to cooperate with the projecting pins on the base. The annular snapring also has means on the inner portion thereof for snapping into engagement with a cam engaging surface on the base member. The inner surface of the snapring is so shaped as to form a smooth, continuous path over the snapring and through the central aperture.
The invention will now be described with reference to the accompanying drawings in which:
FIG. 1 is a perspective view of an embodiment of the invention;
FIG. 2 is a sectional view through a base member of the valve shown in FIG. 1 as placed into a heart;
FIG. 3 is a sectional view of an assembled valve shown in part in FIG. 2;
FIG. 4 is a sectional view of a modified valve according to the invention;
FIG. 5 is a bottom view of the modified valve shown in FIG.
FIG. 6 is a side view, partly in section, of the valve shown in FIGS. 1 through 3, and a portion of an instrument for holding the valve while it is inserted into the heart;
FIG. 7 is a view similar to FIG. 6 showing the complete instrument for inserting the valve into the heart, and illustrating the method of inserting the valve into the heart; and
FIG. 8 is an exploded view of the holding and positioning instrument shown in FIGS. 6 and 7.
Referring now to the drawings, and FIGS. 1 through 3 in particular, a novel sutureless heart valve has a base 2 and a snap engaging ring 18. The base 2 has a plurality of spaced axially extending ball retaining legs 8 having their outer ends curved inwardly and joined at a central point along the longitudinal axis of the base member. The base also includes a ball valve I0 which is seated against inner annular surface 12 of base member 2. The inner annular surface is smooth and provides a central aperture in the base member. The ball 10 is free to reciprocate within the ball retaining legs 8 to open and close the valve. The base comprises an annular shoulder 14 and an axially and inwardly extending flange member 16. A base further contains a plurality of axially directed prongs 6 spaced about the outer periphery of the base. The snapring 18 comprises an annular ring of sufficient diameter to fit over the projecting pins 6 and has a smooth inner surface 24. Shoulder 20 of ring 18 abuts against shoulder 14 when the ring is snapped in place. The snapring has an inwardly and axially extending shoulder 28 which cooperates with flange 16 of the base member to snap into place. Shoulder 20 is slightly rounded so as to provide a camming surface against flange 16 in the snap engagement of ring 18 with base 2. The smooth inner surface 24 of ring 18 forms a continuous smooth surface with upper flange portion 19. The pins 6 fit into an annular recess 21 when the ring 18 is snapped into place in base 2.
In operation, the normal valve in a heart is removed, thereby leaving an aperture. The base member 2 is pushed through the aperture and pulled back slightly. Tissue 4 is then pulled over the outer annular recess in base 2 and over the projecting pins 6. The tissue does not extend over flange 16. The snapring is then pushed into place with the rounded shoulder 20 camming against flange 16. As can be seen from FIG. 3, the base 2 and the snapring 18 are so shaped as to provide a smooth, continuous surface through the inner aperture of the valve. As can also be seen from FIG. 3, the tissue is held in place between the base 2 and snapring 18 by pins 6.
Referring now to FIGS. 4 and 5, wherein a second embodiment is shown, a base 52 is provided with a bar 58 which retains flexible disc 60, the check valve formed by the flexible disc seating against the inner annular portion of the valve. The base 52 also contains a plurality of axially projecting pins 56 spaced about the outer periphery thereof. The base 52 also contains axially and outwardly extending flange 62 which has a smooth, continuous inner surface. The snapring 64 has a rounded shoulder 66 which cams against the flange 62. The inner annular portion of snapring 64 is shaped at an angle to the axial direction at flange 62 so that a locking engagement is provided between the base 52 and the snapring 64. The external diameter of snapring 64 is sufficient to fit over projecting pins 56 of base 52.
The snapring 64 can be provided with a plurality of axially projecting pins extending toward base 52 in intermediate positions between the outer and inner diameter thereof to further aid in holding tissue 4 in place.
As can be seen from FIGS. 4 and 5, the valve provides a smooth inner surface which mates with the upper snapring to provide a substantially continuous, smooth surface over which the fluid can flow without increasing dangers of turbulent flow.
Whereas the embodiment of FIG. 1 has been described with reference to a sutureless valve having a ball valve, it is also within the scope of the invention to provide other kinds of check valves in combination with recited structure. Thus, for example, a lenticular valve or the flat, leaflet-type of valve shown in the embodiment of FIGS. 4 and 5 can be provided. Similarly, the ball valve of FIGS. 1 through 3 could be employed in place of the leaflet valve of FIGS. 4 and 5.
EXAMPLE A valve of the type shown in the FIGS. 1 through 3 was placed into the heart of a dog. During the operation. the normal valve in the dogs heart was cut out and replaced by the valve of the invention. The base of the valve was pushed through the aperture'in the heart, and the tissue around the aperture was placed over the pins in the base member. The snapring was then placed on top of the valve and the dog was sewn up. The total time required for insertion of the valve was 7 minutes. An X-ray was taken of the valve, and indicated that the valve was successfully and suitably placed in the heart.
After the dog expired, the heart was removed and dissected. The valve was firmly intact, and operated successfully.
Referring now to FIGS. 6, 7, and 8, a holding tube 70 having a plurality of longitudinal slits 72 is employed in holding base 2 in position within the heart. Positioned within the holding tube 70 is a rod 76 having attached to the end thereof an expander 74. A drawing tube 78 has an end member 80 which threadably engages a threaded portion 82 of rod 76. Drawing tube 78 has a pair of oppositely spaced holes 92 in which is removably positioned a turning pin 84.
When the drawing tube 78 is rotated relative to the holding tube 70, for example in the direction of the arrow shown in FIG. 6, the expander is drawn into holding tube 72 to expand the end of that tube against the inner wall portion of base 2.
A snapring pusher 86 having a longitudinal slot 88 and an end member 90 is provided to push the snapring 18 into fixed engagement with base 2.
In operation, base 2 is positioned on the slotted end of holding tube 70. Drawing tube 78 is rotated with the aid of pin 84 until the expander 74 has forced the end of holding tube 70 against base 2 to firmly hold'the same. The base 2 is then positioned in the aperture in the heart and tissue 4 is folded over pins 6. The turning pin 84 is then removed from drawing tube 78 and the snapring I8 is placed over drawing tube 78 and holding tube 70 while the two tubes are held in position. The snapring pusher 86 is then placed over the end of drawing tube 78 while holding the slotted portion of holding tube 70. The longitudinal slots 88 of snapring pusher 86 are positioned opposite holes 92 of drawing tube 78. The turning pin 84 is then inserted through longitudinal slots 88 into holes 92. The snapring pusher 86 is then forced against the snapring by pushing the end 90 of snapring pusher 86, for example with the palm of the hand, while holding the turning pin 84 with two fingers of the same hand. In this manner, the snapring 18 is snapped into place on the base 2.
The tube 70 can be removed by the opposite procedure. The snapring pusher 86 is moved away from the heart while holding pin 84 until the pin reaches the end of slots 88. The holding tube 70 can then be held and the pin 84 is removed. After the snapring pusher 86 has been removed from the end of drawing tube 78, the drawing tube 78 is rotated relative to holding tube 70, with the aid of pin 84, in order to move the expander 74 out of the end of the holding tube 70. After this has been done, the holding tube 70 can be removed from the valve.
Reasonable variation and modification are possible within the scope of the foregoing disclosure, the drawings, and the appended claims to the invention without departing from the spirit thereof.
The embodiment of the invention in which an exclusive property or privilege is claimed are defined as follows:
l. A sutureless heart valve comprising:
an annular-shaped base member having a central aperture therein; valve means attached to said base member and operable within said apenure to block flow through said aperture;
an annular-shaped snapring for joining said base and valve means to the surrounding heart tissue, said snapring being joined to said base member through a snap fit so that the heart tissue is firmly held between said ring and base, the inner surfaces of said ring and base being so shaped to form a smooth continuous surface over said snapring and through said central aperture; and
a plurality of pins extending, in an axial direction between said base member and said snapring so that when said snapring is joined to said base, said pins pierce said heart tissue to anchor said tissue between said base and ring, said pins being spaced radially from said aperture.
2. A sutureless heart valve according to claim 1, wherein said base includes an axially and inwardly extending flange, and said ring includes an axially and outwardly extending surface in juxtaposed relationship with said base flange.
3. A sutureless heart valve according to claim 2, wherein said outwardly and axially extending surface on said ring has a rounded corner for camming against said base flange during assembly of said valve.
4. A sutureless heart valve according to claim 3 wherein said pins are mounted on said base, and said snapring flange is of sufficient diameter to fit over said pins when said snapring is joined to said base, said snapring flange further including an annular recess for receipt of said pins when said snapring is joined to said base to provide positive locking of the tissue between the base and ring. 7
5. A sutureless heart valve according to claim I, wherein said valve means is a ball and said base is provided with a plurality of spaced legs extending axially of said base member and having their outer ends curved inwardly and joined at a central point along the longitudinal axis of said base and enclosing said ball which is reciprocatable within said legs and seats against said annular base member to close off said central aperture.
6. A sutureless heart valve according to claim 1, wherein said valve means comprises a movable disc operably adjacent a face of said base member to block flow through said central aperture and means on said base enclosing said disc, said disc being reciprocable in said enclosing means to move away from said base to permit fluid flow through said central aperture.
7. A sutureless heart valve comprising, in combination:
an annular-shaped base member having a central aperture therein;
check valve means in said central aperture being attached to said base member;
an annular shaped snapring;
means attaching said snapring to said base member through a snap fit, the inner surface of said base member and said snapring being so shaped to form a smooth, continuous surface over said snapring and through said central aperture, said attaching means comprising an axially directed flange with an outwardly extending wall on said snapring and an axially and inwardly extending flange on said base, spaced from said central aperture in juxtaposed relationship with said snapring flange, the inner diameter of said base flange being slightly smaller than the outer diameter of said outwardly extending wall at opposing positions of said wall and said base flange; and
a plurality of pins extending in an axial direction between said base member and snapring spaced from said aperture.
8. A sutureless heart valve according to claim 7 wherein said outwardly extending wall of said snapring has a rounded edge which is adapted to cam against said inwardly extending flange during assembly of said valve.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3130419 *||Apr 24, 1961||Apr 28, 1964||Edwards Miles Lowell||Heart valve with shielded sewing ring|
|US3416159 *||May 24, 1965||Dec 17, 1968||Sutter Hospital Medical Res Fo||Double-cage heart valve with contoured oversize orifice|
|DE1180087B *||Mar 26, 1964||Oct 22, 1964||Dr Wolfgang Seidel||Herzklappenprothese|
|SU180750A *||Title not available|
|1||*||Beall Mitral Valve Prosthesis Surgitool Inc. Advertisement, The Journal of Thoracic & Cardiovascular Surgery, Vol. 55, No. 2, Feb. 1968, Advertising Page 27. 3-1HV|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3874388 *||Feb 12, 1973||Apr 1, 1975||Ochsner Med Found Alton||Shunt defect closure system|
|US3906549 *||Jul 17, 1974||Sep 23, 1975||Bucalo Louis||Implanting structure and method|
|US4506394 *||Jan 13, 1983||Mar 26, 1985||Molrose Management, Ltd.||Cardiac valve prosthesis holder|
|US4687483 *||Sep 11, 1985||Aug 18, 1987||University Court Of The University Of Glasgow||Heart valve prosthesis|
|US4932965 *||Dec 19, 1988||Jun 12, 1990||Phillips Steven J||Artificial valve, and needle and suture holder and method of using same|
|US5397351 *||May 13, 1991||Mar 14, 1995||Pavcnik; Dusan||Prosthetic valve for percutaneous insertion|
|US5423887 *||Aug 3, 1992||Jun 13, 1995||Autogenics||Rapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignment|
|US5489298 *||Mar 7, 1995||Feb 6, 1996||Autogenics||Rapid assembly concentric mating stent, tissue heart valve with enhanced clamping and tissue exposure|
|US5522885 *||May 5, 1994||Jun 4, 1996||Autogenics||Assembly tooling for an autologous tissue heart valve|
|US5531784 *||Mar 10, 1994||Jul 2, 1996||Autogenics||Test device for and method of testing rapid assembly tissue heart valve|
|US5571174 *||Nov 18, 1994||Nov 5, 1996||Autogenics||Method of assembling a tissue heart valve|
|US5571175 *||Jun 7, 1995||Nov 5, 1996||St. Jude Medical, Inc.||Suture guard for prosthetic heart valve|
|US5607470 *||May 1, 1995||Mar 4, 1997||Milo; Simcha||Suture rings for prosthetic heart valves|
|US5628789 *||Sep 11, 1995||May 13, 1997||St. Jude Medical, Inc.||Apparatus for attachment of heart valve holder to heart valve prosthesis|
|US5653749 *||Jun 2, 1994||Aug 5, 1997||Autogenics||Prefabricated, sterile and disposable kits for the rapid assembly of a tissue heart valve|
|US5697382 *||Jun 6, 1995||Dec 16, 1997||Autogenics||Heart valve assembly method|
|US5713952 *||Sep 11, 1995||Feb 3, 1998||St. Jude Medical, Inc.||Apparatus for attachment of heart valve holder to heart valve prosthesis|
|US5735842 *||Sep 11, 1995||Apr 7, 1998||St. Jude Medical, Inc.||Low profile manipulators for heart valve prostheses|
|US5776188 *||Nov 12, 1996||Jul 7, 1998||St. Jude Medical, Inc.||Direct suture orifice for mechanical heart valve|
|US5807405 *||Sep 11, 1995||Sep 15, 1998||St. Jude Medical, Inc.||Apparatus for attachment of heart valve holder to heart valve prosthesis|
|US5814101 *||Sep 25, 1996||Sep 29, 1998||St. Jude Medical, Inc.||Holder for heart valve prosthesis|
|US5824068 *||Aug 7, 1997||Oct 20, 1998||St. Jude Medical, Inc.||Cardiac valve holders|
|US5843178 *||Jun 20, 1996||Dec 1, 1998||St. Jude Medical, Inc.||Suture guard for annuloplasty ring|
|US5843179 *||Oct 21, 1996||Dec 1, 1998||St. Jude Medical, Inc.||Suture guard for prosthetic heart valve|
|US5855601 *||Jun 21, 1996||Jan 5, 1999||The Trustees Of Columbia University In The City Of New York||Artificial heart valve and method and device for implanting the same|
|US5876437 *||Apr 4, 1997||Mar 2, 1999||St. Jude Medical, Inc.||Apparatus for attachment of heart valve holder to heart valve prosthesis|
|US5957976 *||Mar 18, 1997||Sep 28, 1999||St. Jude Medical, Inc.||Apparatus for attachment of heart valve holder to heart valve prosthesis|
|US5984959 *||Sep 19, 1997||Nov 16, 1999||United States Surgical||Heart valve replacement tools and procedures|
|US6059827 *||May 4, 1998||May 9, 2000||Axya Medical, Inc.||Sutureless cardiac valve prosthesis, and devices and methods for implanting them|
|US6074418 *||Dec 1, 1998||Jun 13, 2000||St. Jude Medical, Inc.||Driver tool for heart valve prosthesis fasteners|
|US6096074 *||Jan 27, 1998||Aug 1, 2000||United States Surgical||Stapling apparatus and method for heart valve replacement|
|US6176877||Apr 20, 1998||Jan 23, 2001||St. Jude Medical, Inc.||Two piece prosthetic heart valve|
|US6197054||Sep 1, 1998||Mar 6, 2001||Sulzer Carbomedics Inc.||Sutureless cuff for heart valves|
|US6254642 *||Dec 9, 1997||Jul 3, 2001||Thomas V. Taylor||Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof|
|US6319280||Aug 3, 1999||Nov 20, 2001||St. Jude Medical, Inc.||Prosthetic ring holder|
|US6413274||Jan 18, 2000||Jul 2, 2002||United States Surgical Corporation||Stapling apparatus and method for heart valve replacement|
|US6468305||May 16, 2000||Oct 22, 2002||St. Jude Medical, Inc.||Two piece valve|
|US6558429||Mar 26, 2001||May 6, 2003||Reflux Corporation||Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof|
|US6786925||Oct 19, 2000||Sep 7, 2004||St. Jude Medical Inc.||Driver tool with multiple drive gear layers for heart prosthesis fasteners|
|US7147663 *||Apr 14, 2000||Dec 12, 2006||St. Jude Medical Atg, Inc.||Artificial heart valve attachment apparatus and methods|
|US7513909||Apr 10, 2006||Apr 7, 2009||Arbor Surgical Technologies, Inc.||Two-piece prosthetic valves with snap-in connection and methods for use|
|US7569072||Nov 23, 2005||Aug 4, 2009||St. Jude Medical Atg, Inc.||Artificial heart valve attachment apparatus and methods|
|US7641687 *||Nov 2, 2004||Jan 5, 2010||Carbomedics Inc.||Attachment of a sewing cuff to a heart valve|
|US7708775||May 24, 2006||May 4, 2010||Edwards Lifesciences Corporation||Methods for rapid deployment of prosthetic heart valves|
|US7717955||Feb 28, 2005||May 18, 2010||Medtronic, Inc.||Conformable prosthesis for implanting two-piece heart valves and methods for using them|
|US7722667||May 17, 2000||May 25, 2010||St. Jude Medical, Inc.||Two piece bioprosthetic heart valve with matching outer frame and inner valve|
|US7731757||Jun 1, 2004||Jun 8, 2010||Reflux Corporation||Obesity treatment|
|US7819915||Dec 19, 2003||Oct 26, 2010||Edwards Lifesciences Corporation||Heart valve holders and handling clips therefor|
|US7951197||Apr 6, 2009||May 31, 2011||Medtronic, Inc.||Two-piece prosthetic valves with snap-in connection and methods for use|
|US7959674||Mar 3, 2004||Jun 14, 2011||Medtronic, Inc.||Suture locking assembly and method of use|
|US7967857||Jan 29, 2007||Jun 28, 2011||Medtronic, Inc.||Gasket with spring collar for prosthetic heart valves and methods for making and using them|
|US7972377||Aug 29, 2008||Jul 5, 2011||Medtronic, Inc.||Bioprosthetic heart valve|
|US7981153||Mar 14, 2005||Jul 19, 2011||Medtronic, Inc.||Biologically implantable prosthesis methods of using|
|US8021161||May 1, 2006||Sep 20, 2011||Edwards Lifesciences Corporation||Simulated heart valve root for training and testing|
|US8021421 *||Aug 22, 2003||Sep 20, 2011||Medtronic, Inc.||Prosthesis heart valve fixturing device|
|US8025695 *||Jan 31, 2003||Sep 27, 2011||Medtronic, Inc.||Biologically implantable heart valve system|
|US8083793||Feb 28, 2005||Dec 27, 2011||Medtronic, Inc.||Two piece heart valves including multiple lobe valves and methods for implanting them|
|US8092523 *||Mar 12, 2007||Jan 10, 2012||St. Jude Medical, Inc.||Prosthetic heart valves with flexible leaflets|
|US8142496||Mar 13, 2009||Mar 27, 2012||Daidalos Solutions B.V.||Fixing device, in particular for fixing to vascular wall tissue|
|US8163014||Apr 5, 2010||Apr 24, 2012||Medtronic, Inc.||Conformable prostheses for implanting two-piece heart valves and methods for using them|
|US8211169||May 26, 2006||Jul 3, 2012||Medtronic, Inc.||Gasket with collar for prosthetic heart valves and methods for using them|
|US8308798||Dec 10, 2009||Nov 13, 2012||Edwards Lifesciences Corporation||Quick-connect prosthetic heart valve and methods|
|US8348998||Jun 23, 2010||Jan 8, 2013||Edwards Lifesciences Corporation||Unitary quick connect prosthetic heart valve and deployment system and methods|
|US8349003||Apr 12, 2011||Jan 8, 2013||Medtronic, Inc.||Suture locking assembly and method of use|
|US8435203 *||Jun 20, 2007||May 7, 2013||Covidien Lp||Gastric restrictor assembly and method of use|
|US8449625||Oct 27, 2009||May 28, 2013||Edwards Lifesciences Corporation||Methods of measuring heart valve annuluses for valve replacement|
|US8460373||Jul 1, 2011||Jun 11, 2013||Medtronic, Inc.||Method for implanting a heart valve within an annulus of a patient|
|US8500798||May 24, 2006||Aug 6, 2013||Edwards Lifesciences Corporation||Rapid deployment prosthetic heart valve|
|US8500802||Mar 8, 2011||Aug 6, 2013||Medtronic, Inc.||Two-piece prosthetic valves with snap-in connection and methods for use|
|US8506625||Aug 9, 2010||Aug 13, 2013||Edwards Lifesciences Corporation||Contoured sewing ring for a prosthetic mitral heart valve|
|US8535373||Jun 16, 2008||Sep 17, 2013||Sorin Group Italia S.R.L.||Minimally-invasive cardiac-valve prosthesis|
|US8539662||Jun 16, 2008||Sep 24, 2013||Sorin Group Italia S.R.L.||Cardiac-valve prosthesis|
|US8540768||Dec 30, 2011||Sep 24, 2013||Sorin Group Italia S.R.L.||Cardiac valve prosthesis|
|US8551162 *||Dec 20, 2002||Oct 8, 2013||Medtronic, Inc.||Biologically implantable prosthesis|
|US8574257||Aug 10, 2009||Nov 5, 2013||Edwards Lifesciences Corporation||System, device, and method for providing access in a cardiovascular environment|
|US8603161||Jul 6, 2009||Dec 10, 2013||Medtronic, Inc.||Attachment device and methods of using the same|
|US8623080 *||Sep 22, 2011||Jan 7, 2014||Medtronic, Inc.||Biologically implantable prosthesis and methods of using the same|
|US8641757||Jun 23, 2011||Feb 4, 2014||Edwards Lifesciences Corporation||Systems for rapidly deploying surgical heart valves|
|US8696742||Oct 10, 2012||Apr 15, 2014||Edwards Lifesciences Corporation||Unitary quick-connect prosthetic heart valve deployment methods|
|US8747463||Aug 3, 2011||Jun 10, 2014||Medtronic, Inc.||Methods of using a prosthesis fixturing device|
|US8790290||Apr 29, 2013||Jul 29, 2014||Covidien Lp||Gastric restrictor assembly and method of use|
|US8808369||Oct 5, 2010||Aug 19, 2014||Mayo Foundation For Medical Education And Research||Minimally invasive aortic valve replacement|
|US8821569||Apr 30, 2007||Sep 2, 2014||Medtronic, Inc.||Multiple component prosthetic heart valve assemblies and methods for delivering them|
|US8834563||Dec 16, 2009||Sep 16, 2014||Sorin Group Italia S.R.L.||Expandable prosthetic valve having anchoring appendages|
|US8840661||May 13, 2009||Sep 23, 2014||Sorin Group Italia S.R.L.||Atraumatic prosthetic heart valve prosthesis|
|US8840664||Jun 14, 2012||Sep 23, 2014||Edwards Lifesciences Corporation||Heart valve prosthesis anchoring device and methods|
|US8845720||Sep 20, 2011||Sep 30, 2014||Edwards Lifesciences Corporation||Prosthetic heart valve frame with flexible commissures|
|US8911493||Jul 30, 2013||Dec 16, 2014||Edwards Lifesciences Corporation||Rapid deployment prosthetic heart valves|
|US8920492||Aug 21, 2013||Dec 30, 2014||Sorin Group Italia S.R.L.||Cardiac valve prosthesis|
|US8986374||May 10, 2011||Mar 24, 2015||Edwards Lifesciences Corporation||Prosthetic heart valve|
|US9005277||Dec 21, 2012||Apr 14, 2015||Edwards Lifesciences Corporation||Unitary quick-connect prosthetic heart valve deployment system|
|US9005278||Oct 25, 2012||Apr 14, 2015||Edwards Lifesciences Corporation||Quick-connect prosthetic heart valve|
|US9078747||Nov 13, 2012||Jul 14, 2015||Edwards Lifesciences Corporation||Anchoring device for replacing or repairing a heart valve|
|US9125741||Mar 12, 2013||Sep 8, 2015||Edwards Lifesciences Corporation||Systems and methods for ensuring safe and rapid deployment of prosthetic heart valves|
|US9155617||Apr 18, 2014||Oct 13, 2015||Edwards Lifesciences Corporation||Prosthetic mitral valve|
|US9161836||Feb 10, 2012||Oct 20, 2015||Sorin Group Italia S.R.L.||Sutureless anchoring device for cardiac valve prostheses|
|US9248016||Mar 3, 2010||Feb 2, 2016||Edwards Lifesciences Corporation||Prosthetic heart valve system|
|US9248017||May 20, 2011||Feb 2, 2016||Sorin Group Italia S.R.L.||Support device for valve prostheses and corresponding kit|
|US9289289||Feb 10, 2012||Mar 22, 2016||Sorin Group Italia S.R.L.||Sutureless anchoring device for cardiac valve prostheses|
|US9314334||Nov 25, 2013||Apr 19, 2016||Edwards Lifesciences Corporation||Conformal expansion of prosthetic devices to anatomical shapes|
|US9333078||Nov 22, 2013||May 10, 2016||Medtronic, Inc.||Heart valve assemblies|
|US9370418||Mar 12, 2013||Jun 21, 2016||Edwards Lifesciences Corporation||Rapidly deployable surgical heart valves|
|US9402719||Apr 23, 2012||Aug 2, 2016||Medtronic, Inc.||Conformable prostheses for implanting two-piece heart valves and methods for using them|
|US9439762||Jan 23, 2013||Sep 13, 2016||Edwards Lifesciences Corporation||Methods of implant of a heart valve with a convertible sewing ring|
|US9468527||Jun 12, 2014||Oct 18, 2016||Edwards Lifesciences Corporation||Cardiac implant with integrated suture fasteners|
|US9486313||Nov 19, 2014||Nov 8, 2016||Sorin Group Italia S.R.L.||Cardiac valve prosthesis|
|US9504563||Jan 27, 2014||Nov 29, 2016||Edwards Lifesciences Corporation||Rapidly deployable surgical heart valves|
|US9504566||Jun 19, 2015||Nov 29, 2016||Edwards Lifesciences Corporation||Surgical heart valves identifiable post-implant|
|US9549816||Apr 2, 2015||Jan 24, 2017||Edwards Lifesciences Corporation||Method for manufacturing high durability heart valve|
|US9554901||May 11, 2011||Jan 31, 2017||Edwards Lifesciences Corporation||Low gradient prosthetic heart valve|
|US9554903||Dec 15, 2014||Jan 31, 2017||Edwards Lifesciences Corporation||Rapid deployment prosthetic heart valve|
|US9561100||Apr 10, 2015||Feb 7, 2017||Edwards Lifesciences Corporation||Systems for quickly delivering a prosthetic heart valve|
|US9585749 *||Sep 18, 2014||Mar 7, 2017||Boston Scientific Scimed, Inc.||Replacement heart valve assembly|
|US9585752||Apr 29, 2015||Mar 7, 2017||Edwards Lifesciences Corporation||Holder and deployment system for surgical heart valves|
|US9603553||Feb 7, 2013||Mar 28, 2017||Edwards Lifesciences Corporation||Methods of measuring heart valve annuluses for valve replacement|
|US20010020190 *||Mar 26, 2001||Sep 6, 2001||Taylor Thomas V.||Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof|
|US20040122514 *||Jan 31, 2003||Jun 24, 2004||Fogarty Thomas J.||Biologically implantable prosthesis and methods of using the same|
|US20040138741 *||Dec 19, 2003||Jul 15, 2004||Robert Stobie||Heart valve holders and handling clips therefor|
|US20040243152 *||Jun 1, 2004||Dec 2, 2004||Taylor Thomas V.||Obesity treatment|
|US20050228494 *||Mar 29, 2004||Oct 13, 2005||Salvador Marquez||Controlled separation heart valve frame|
|US20060095125 *||Nov 2, 2004||May 4, 2006||Chinn Joseph A||Attachment of a sewing cuff to a heart valve|
|US20060136054 *||Nov 23, 2005||Jun 22, 2006||Berg Todd A||Artificial heart valve attachment apparatus and methods|
|US20060195184 *||Feb 28, 2005||Aug 31, 2006||Ernest Lane||Conformable prosthesis for implanting two-piece heart valves and methods for using them|
|US20060195185 *||Feb 28, 2005||Aug 31, 2006||Ernest Lane||Two piece heart valves including multiple lobe valves and methods for implanting them|
|US20060195186 *||Feb 28, 2005||Aug 31, 2006||Drews Michael J||Connectors for two piece heart valves and methods for implanting such heart valves|
|US20060235508 *||Apr 10, 2006||Oct 19, 2006||Ernest Lane||Two-Piece Prosthetic Valves with Snap-In Connection and Methods for Use|
|US20060287717 *||May 24, 2006||Dec 21, 2006||Rowe Stanton J||Methods for rapid deployment of prosthetic heart valves|
|US20060287719 *||May 24, 2006||Dec 21, 2006||Rowe Stanton J||Rapid deployment prosthetic heart valve|
|US20070016288 *||Jul 13, 2006||Jan 18, 2007||Gurskis Donnell W||Two-piece percutaneous prosthetic heart valves and methods for making and using them|
|US20070150053 *||Dec 7, 2006||Jun 28, 2007||Gurskis Donnell W||Connection Systems for Two Piece Prosthetic Heart Valve Assemblies and Methods for Using Them|
|US20070254273 *||May 1, 2006||Nov 1, 2007||Hugues Lafrance||Simulated heart valve root for training and testing|
|US20080228264 *||Mar 12, 2007||Sep 18, 2008||St. Jude Medical, Inc.||Prosthetic heart valves with flexible leaflets|
|US20080255662 *||Jun 16, 2008||Oct 16, 2008||Sorin Biomedica Cardio S.R.L.||Minimally-invasive cardiac-valve prosthesis|
|US20080319470 *||Jun 20, 2007||Dec 25, 2008||Viola Frank J||Gastric restrictor assembly and method of use|
|US20090171363 *||Dec 22, 2008||Jul 2, 2009||Universite De Franche-Comte||Automated insertion device for heart valve prosthesis|
|US20090234446 *||Mar 13, 2009||Sep 17, 2009||Eric Berreklouw||Fixing device, in particular for fixing to vascular wall tissue|
|US20090287296 *||May 13, 2009||Nov 19, 2009||Sorin Biomedica Cardio S.R.L.||Atraumatic prosthetic heart valve prosthesis|
|US20100063363 *||Aug 10, 2009||Mar 11, 2010||Hamman Baron L||System, device, and method for providing access in a cardiovascular environment|
|US20100161036 *||Dec 10, 2009||Jun 24, 2010||Edwards Lifesciences Corporation||Quick-connect prosthetic heart valve and methods|
|US20100161045 *||Dec 16, 2009||Jun 24, 2010||Sorin Biomedica Cardio S.R.L.||Expandable prosthetic valve having anchoring appendages|
|US20100191327 *||Apr 5, 2010||Jul 29, 2010||Medtronic, Inc.||Conformable prostheses for implanting two-piece heart valves and methods for using them|
|US20100249894 *||Mar 3, 2010||Sep 30, 2010||Edwards Lifesciences Corporation||Prosthetic heart valve system|
|US20100249908 *||Mar 2, 2010||Sep 30, 2010||Edwards Lifesciences Corporation||Prosthetic heart valve system with positioning markers|
|US20100331972 *||Jun 23, 2010||Dec 30, 2010||Edwards Lifesciences Corporation||Unitary Quick Connect Prosthetic Heart Valve and Deployment System and Methods|
|US20110054598 *||Aug 9, 2010||Mar 3, 2011||Edwards Lifesciences Corporation||Contoured Sewing Ring for a Prosthetic Mitral Heart Valve|
|US20110098602 *||Oct 27, 2009||Apr 28, 2011||Edwards Lifesciences Corporation||Apparatus and Method for Measuring Body Orifice|
|US20110190877 *||Mar 8, 2011||Aug 4, 2011||Medtronic, Inc.||Two-Piece Prosthetic Valves with Snap-In Connection and Methods for Use|
|US20120053688 *||Sep 22, 2011||Mar 1, 2012||Medtronic, Inc.||Biologically Implantable Prosthesis and Methods of Using the Same|
|US20150073541 *||Sep 18, 2014||Mar 12, 2015||Sadra Medical, Inc.||Repositionable Heart Valve and Method|
|USRE40377||Jun 7, 2004||Jun 10, 2008||Cardiovascular Technologies Llc||Means and method of replacing a heart valve in a minimally invasive manner|
|USRE44075 *||Jun 5, 2008||Mar 12, 2013||Medtronic, Inc.||Means and method of replacing a heart valve in a minimally invasive manner|
|DE2345275A1 *||Sep 7, 1973||Mar 21, 1974||Medical Inc||Ansatzhuelse|
|EP0179562A1 *||Sep 16, 1985||Apr 30, 1986||The University of Glasgow, University Court||A heart valve prosthesis|
|EP0569450A1 *||Jan 13, 1992||Nov 18, 1993||Autogenics||Heart valve with tissue alignment and clamping|
|EP0569450A4 *||Jan 13, 1992||Jul 13, 1994||Autogenics||Heart valve with tissue alignment and clamping|
|EP1076532A1 *||Apr 13, 1999||Feb 21, 2001||Axya Medical Inc.||Sutureless cardiac valve prosthesis, and devices and methods for implanting them|
|EP1076532A4 *||Apr 13, 1999||Jul 15, 2009||Axya Medical Inc||Sutureless cardiac valve prosthesis, and devices and methods for implanting them|
|EP1584307A2 *||Apr 14, 2000||Oct 12, 2005||St.Jude Medical ATG, Inc.||Artificial heart valve with attachment fingers|
|EP1584307A3 *||Apr 14, 2000||Oct 19, 2005||St.Jude Medical ATG, Inc.||Artificial heart valve with attachment fingers|
|EP1967163A2||Apr 25, 2000||Sep 10, 2008||Eric Berreklouw||Fixing device, in particular for fixing to vascular wall tissue|
|EP2258313A2||Apr 25, 2000||Dec 8, 2010||Eric Berreklouw||Assembly comprising a fixing device for fixing to vascular wall tissue|
|EP2258314A2||Apr 25, 2000||Dec 8, 2010||Eric Berreklouw||Portal and/or obturator assembly comprising a fixing device for fixing to vascular wall tissue surrounding a passage|
|EP2258315A2||Apr 25, 2000||Dec 8, 2010||Eric Berreklouw||Arrangement comprising a fixing device for fixing to vascular wall tissue and a sleeve|
|EP2258316A2||Apr 25, 2000||Dec 8, 2010||Eric Berreklouw||Ring prosthesis for reducing the size of the passage of a heart valve|
|EP2486893A1||Feb 14, 2011||Aug 15, 2012||Sorin Biomedica Cardio S.r.l.||Sutureless anchoring device for cardiac valve prostheses|
|EP2486894A1||Feb 14, 2011||Aug 15, 2012||Sorin Biomedica Cardio S.r.l.||Sutureless anchoring device for cardiac valve prostheses|
|WO1996040011A1 *||Jun 7, 1996||Dec 19, 1996||St. Jude Medical, Inc.||Direct suture orifice for mechanical heart valve|
|WO1999053845A1||Apr 19, 1999||Oct 28, 1999||St. Jude Medical, Inc.||Driver tool for heart valve prosthesis fasteners|
|WO1999053869A1||Apr 19, 1999||Oct 28, 1999||St. Jude Medical, Inc.||Two piece prosthetic heart valve|
|WO1999056665A1 *||Apr 13, 1999||Nov 11, 1999||Axya Medical, Inc.||Sutureless cardiac valve prosthesis, and devices and methods for implanting them|
|WO2000012032A1 *||Sep 1, 1999||Mar 9, 2000||Sulzer Carbomedics Inc.||Sutureless cuff for heart valves|
|WO2000044311A2||Apr 25, 2000||Aug 3, 2000||Eric Berreklouw||Fixing device, in particular for fixing to vascular wall tissue|
|WO2012110928A1||Feb 10, 2012||Aug 23, 2012||Sorin Biomedica Cardio S.R.L.||"sutureless anchoring device for cardiac valve prostheses"|
|WO2012110929A1||Feb 10, 2012||Aug 23, 2012||Sorin Biomedica Cardio S.R.L.||Sutureless anchoring device for cardiac valve prostheses|
|U.S. Classification||623/2.34, 606/220, 623/2.38|
|Cooperative Classification||A61F2/2424, A61F2/2409|
|European Classification||A61F2/24F2, A61F2/24C|