Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.


  1. Advanced Patent Search
Publication numberUS3587899 A
Publication typeGrant
Publication dateJun 28, 1971
Filing dateApr 10, 1967
Priority dateApr 10, 1967
Publication numberUS 3587899 A, US 3587899A, US-A-3587899, US3587899 A, US3587899A
InventorsBender Charles E, Fraser Douglas, Thompson Taylor N
Original AssigneeBender Charles E, Fraser Douglas, Thompson Taylor N
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Freeze drying container
US 3587899 A
Abstract  available in
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

United States Patent [72] inventors Charles E. Bender 61 Millrock Road: Taylor N. Thompson. 31 Horsenden Road; Douglas Fraser, 12 S. Oakwood Terrace. New Pa1tz,.\.i'. 13561 [211 App]. No. 629,469 [22 Filed Apr. 10, 1967 [45] Patented June 28,1971

[541 FREEZE DRYING CONTAINER 2 Claims, 4 Drawing Figs.

[52] [1.5. CI 215/73, 285/177 [51} 1nt.Cl f B65d 47/14 [50] Field of Search 215/7147 (Cursory); 285/177, 302, 355 (lnquired) [56] References Cited UNITED STATES PATENTS 1.152546 9/1915 Phillips 215/73 1,760,841 5/1930 Garhart 215/73 2,677,482 5/1954 Lehmann 215/73UX 652.793 7/1900 Low 215/73 Primary ExaminerDonald F. Norton Attorneyl. Walton Bader ABSTRACT: A freeze drying container for animal organs is shown which is formed of a transparent bottle having a wide mouth opening. The mouth opening carries a side portion which bears lateral threads. A cover member overlies the mouth portion and bears additional lateral threads disposed upon a downwardly depending portion. The additional lateral threads mate with the first-named lateral threads upon the side portion of the mouth opening. The cover member is provided with a narrower opening therewithin. An open tube member is formed with an outwardly extending flange which underlies the narrower opening. The tube member projects upwardly from the opening. The tube member is adapted to be connected to a vacuum pump.

FREEZE DRYING CONTAINER DESCRIPTION OF THE INVENTION This invention relates to a freeze drying container for animal organs and is particularly utilizable in preparing freeze dried organs for use in organ banks and the like.

With the increased use of tissue transplants it has become general practice to store organs which have been removed from those who have died in organ banks where these organs can be used to advantage for such tissue transplant into others. These organs are generally preserved by the freeze drying process and held in a sealed sterile container under vacuum dried conditions until ready to be used. Since these organs are of large size a relatively large diameter container is required. Also, of course, the mouth portion of the container must also be relatively large to permit the organ to be inserted therein. A large mouth container is unsatisfactory in freeze drying procedures for various reasons. In the first place, a large mouth would require a large stopper and use ofa large stopper means that high stoppering pressure must be applied to the container in order to seal the same. Furthermore, the use of such large stopper means that there is a large surface area permitting large permeation of air and great possibilities of leakage.

The invention described in this specification eliminates the disadvantages set forth above. While the holding portion for the organs is of relatively large size and provided with a wide mouth, structure is provided which permits the use of a narrow mouth for aspiration connection to a vacuum freeze drying system. This is accomplished by providing a cover secured to the mouth of the container which bears an additional opening therewithin which is narrower than the mouth opening. An open tube member is disposed within the narrower opening and this narrower tube member is in turn connected to a vacuum pump. Optionally the tube member bears a lateral outwardly projecting flange which underlies the narrower opening, a gasket is provided between the flange and the wide mouth of the holding portion, and automatic stoppering means are provided within an end portion of the tube to permit utilization of the container as a storage means for the organs or organ involved.

The invention described herein can also be used as a bulk container for freeze drying of material such as blood plasma, whole blood, etc. While such liquid materials could be simply inserted into a narrow mouth container the use of such material would present serious problems since it might be difficult to get to the contents of a wide container through a narrow mouth.

The above constitutes a brief description of this invention and some of the objects and advantages thereof. Other objects and advantages of this invention will become apparent to the reader ofthis specification as the description proceeds.

The invention will be further described by reference to the accompanying drawings which are made a part of this specification.

FIG. 1 is a plan view of the freeze drying container made in accordance with this invention. This view also shows the mechanism for automatic stoppering of the container after the freeze drying process is completed. The automatic stoppering mechanism per se is disclosed and claimed in our copending application Ser. No. 611,941 filed Jan. 26, 1967, now U.S. Pat. No. 3,465,342 and is not separately claimed in this application. No disclaimer of this subject matter is intended by reason ofthe failure to separately claim the same per se in this application.

FIG. 2 is a perspective view, partly in section, of the freeze drying container as shown in FIG. 1. In this view the organ contained with the holding portion and the gasket optionally employed between the base of the tube and the mouth of the container are not shown for clarity ofillustration and the automatic stoppering mechanism is shown in the closed position that the parts assume after completion of the freeze drying process.

FIG. 3 is a view generally similar to that of FIG. 2 but showing the position of the parts of the automatic stoppering mechanism that they assume when the freeze drying process is operating.

FIG. 4 is a view of the container of this invention with the parts shown in the position that they assume after the freeze drying process is completed and the container is stored.

The invention will now be further described by reference to the specific form thereof as shown in the drawings. In this connection, however, the reader is cautioned to note that the specific form of this invention as set forth in this specification herein is for illustrative purposes and for purposes of example only. Various changes and modifications can obviously be made within the spirit and scope of this invention.

Now referring to the drawings of this specification for a detailed description of this invention the device involved is formed with a holding or organ receiving portion 11. Portion 11 is preferably a glass transparent bottle of suitable size to receive the organ to be freeze dried and thence stored. The organ itself is not shown in the drawings.

The organ receiving portion 11 is provided with a relatively wide mouth 12 which is formed with a lateral portion 13 carrying threads 14.

Overlying mouth 12 is a cover 15 having a downwardly depending portion 16 which carries mating threads 17. Within cover 15 is an opening 18 which is preferably centrally disposed therewithin. An adapter includes a tube 19 projecting through opening 18 and carries an outwardly extending lateral portion 20 disposed on the underside of cover 15.

Between the lower portion of tube 19 and the abutting portion 21 of portion 11 a gasket (not shown) is preferably disposed so as to permit proper seal of the parts. The gasket is provided with a centrally disposed hole (also not shown) which registers with hole 22 located within tube 19. At the upper portion of tube 19 is a threaded lateral portion 23. A stopper 24 is adapted to be placed within the upper portion of tube 19 in order to seal the same. Stopper 24 is provided with a cutout portion 25 whose function will be subsequently described.

Overlying tube 19 is a sealing mechanism 26. This sealing mechanism 26 is specifically disclosed and claimed in our copending application Ser. No. 611,941 filed Jan. 26, 1967. The sealing mechanism consists of a side portion 27, an O-ring 28, a projecting tube portion 29, and an opening 30 provided therewithin. A cap portion 31 is also provided which carries a hole 32 which is in registering relationship with hole 30. Cap 31 bears threads 33 which are adapted to mate with threads 23 to provide axial movement of the adapter on rotation of the adapter relative to the sealing mechanism, thereby seating the stopper 24.

Overlying threads 23 is a storage cap 40. Cap 40 bears mating threads 41 and is not placed into position until the freeze drying process is completed, the sealing mechanism removed, and the container including the freeze dried material stored.

With the foregoing specific description the operation of this invention may now be explained.

Cover 15 is removed from portion 11 and the organ to be freeze dried is deposited into portion 11 through mouth 12. Cover 15 bearing tube 19 is then screwed into position. The remaining structure is then placed into position upon tube 19 as shown in FIG. 3.

Element 29 is then connected to a vacuum freeze drying system and freeze drying'commences with the air being exhausted in the direction of the arrows shown in FIG. 3. When the freeze drying process is completed the parts are placed in the position shown in FIG. 2 which automatically seals the container. Thereafter all of the parts with the exception of member 26 are removed from position about tube 19. At this point, cap 40 is placed in position overlying threads 23.

The foregoing sets forth the manner in which the objects of this invention are achieved.

We claim.

1 A container and stoppering means particularly adapted for use in freeze drying large masses of tissue, organs and the like and thereafter stoppering said container while under vacuum, said container including an organ receiving portion having a relatively large opening forming a mouth, an apertured cover member adapted to cover said mouth, means for fluidtightly and removably attaching said cover to said organ receiving portion, tube means extending from said apertured cover away from said mouth, said tube means having an elongated smooth circumferential portion adapted for circumferential sealing engagement with said stoppering means, thread means on a terminal portion of said tube means for engagement with corresponding thread means in said stoppering means to cause axial movement between said tube and stoppering means and stopper means received in said terminal portion of said tube means for seating therein on axial movement of said stoppering means.

2. An adapter and stoppering means for use in joining wide mouth containers to a source of vacuum and stoppering off said container while under vacuum, said adapter comprising tube means for vacuumtight attachment to said wide mouth container, said tube means including an open end for receiving a stopper, an axially extending circumferentially smooth portion adapted for fluidtight engagement with said stoppering means, thread means on said tube means for engagement with complementary thread means in said stoppering means whereby rotation of said tube means relative to said stoppering means causes axial movement of said open end to seat said stopper, said circumferentially smooth portion maintaining sealing engagement with said stoppering means throughout said axial movement whereby said wide mouth container may be stoppered under vacuum.

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US4060911 *Aug 7, 1975Dec 6, 1977Behringwerke AktiengesellschaftProcess for the preparation of a container closed under sterile conditions and containing lyophilized material
US4251003 *Jan 19, 1979Feb 17, 1981Toni CasuttBottle closing device
US5253900 *Dec 14, 1992Oct 19, 1993Snyder Glenn WConversion adapter for airbrush liquid media reservoir
US7993681 *Oct 22, 2004Aug 9, 2011Fred Hutchinson Cancer Research CenterMethods, compositions and devices for inducing stasis in tissues and organs
US8822535Apr 20, 2006Sep 2, 2014Fred Hutchinson Cancer Research CenterMethods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms
US20120052479 *Jun 21, 2011Mar 1, 2012Roth Mark BMethods, compositions and devices for inducing stasis in tissues and organs
US20130240476 *Nov 23, 2011Sep 19, 2013West Pharmaceutical Services Deautschland GmbH & Co. KGDevice for stopping a container, container provided with such a device, and method for closing a batch of such containers
WO1992019941A1 *Apr 30, 1992Nov 12, 1992Krm Consolidated IncSelf-measuring dispensing device
U.S. Classification215/307
International ClassificationA61B19/00, A61B19/02
Cooperative ClassificationA61B19/02
European ClassificationA61B19/02