|Publication number||US3590808 A|
|Publication date||Jul 6, 1971|
|Filing date||Sep 4, 1968|
|Priority date||Sep 4, 1968|
|Publication number||US 3590808 A, US 3590808A, US-A-3590808, US3590808 A, US3590808A|
|Inventors||Wolf F Muller|
|Original Assignee||Us Catheter & Instr Corp|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (8), Referenced by (120), Classifications (13)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent W011 F. Muller Southampton, N.Y.  AppLNo. 757,366
 Inventor  Filed Sept. 4, 1968  Patented July 6, 1971  Assignee United States Catheter & Instrument Corporation Glens Falls, N.Y.
 BIOPSY TOOL 9 Claims, 12 Drawing Figs.
 US. Cl 128/2 B, 128/305  lnt.C1 ..A61b 10/00 (50] Field of Search 128/2, 2 B, 349, 356, 305, 309, 303-314  References Cited UNITED STATES PATENTS 2,212,133 8/1940 Stadle 128/305 2,684,069 7/1954 Donaldson et al 128/303 2,708,437 5/1955 Hutchins 128/7 3,033,194 5/1962 Lippert 128/2 3,253,524 5/1966 Ashizawa et al. 128/2 UX 3,289,669 12/1966 Dwyer et a1 128/2 3,401 ,684 9/1968 Dremann 128/2 FOREIGN PATENTS 1,451,726 7/1966 France 128/2 Primary Examiner-Richard A. Gaudet Assistant Examiner-Kyle L. Howell Attorney-Saxton Seward ABSTRACT: A biopsy tool that includes a rigid tip affixed to the distal end of a flexible intestinal intubation tube and is provided with a body portion having a longitudinal duct for the passage of an exchange guide and a radial cavity connected through the lumen of the tube to a vacuum source to draw a tissue sample thereinto. A pneumatically operable knife is 1ongitudinally reciprocable across the open end of the cavity to sever the tissue sample contained therein.
PATENTEUJUL 61971 3,590,808
SHEET 2 BF 2 INVENTOR.
BIOPSY TOOL THE INVENTION This invention relates generally to new and useful improvements in biopsy tools and particularly seeks to provide a novel biopsy tool that is affixed to and forms the distal tip of a flexible intestinal intubation tube, particularly of the type of intubation tube that is adapted to be advanced along a previously inserted exchange guide.
Heretofore it has been a long and difficult procedure to insert intubation tubes into the upper gastrointestinal tract through a patients nostril because it was necessary to slowly advance (over a period of several hours) the tube under fluoroscopic control while manipulating the patient through many difflcult postures or positions so that the distal end of the tube would follow the desired path of travel into the stomach and the several sections of the duodenum.
More recently techniques have been developed through which a soft woven catheter containing a proximally controllable distal tip spring guide may be fully inserted into a patient in from -l5 minutes under fluoroscopic control with a minimum of manipulation of the patient. After this initial insertion has been completed the spring guide is withdrawn from its associated catheter and is replaced by an exchange guide normally having a length somewhat greater than twice the inserted length of the catheter so that its exposed proximal end portion is sufficiently long to accept the full length of the intubation tube to be inserted. Then the catheter is withdrawn over the exchange guide, leaving the exchange guide in place ready to receive and lead the intubation tube into its fully inserted position.
A particularly suitable type of controllable tip spring guide for these techniques is disclosed and claimed in my copending application Ser. No. 563,927, filed June 29, 1966, now U.S. Pat. No. 3,452,742 and a particularly suitable exchange guide therefor is disclosed and claimed in my copending application Ser. No. 757,326, filed Sept. 4, 1968.
Although the above-described techniques and equipment are effective for the simple and rapid insertion of intubation tubes, the problem still remains of how to quickly and safely obtain biopsy samples, especially from locations in the upper gastrointestinal tract.
A past approach to solving this problem has been through the use of an intubation tube having its distal end closed by a rigid hollow tip with a radial aperture extending through the wall of the tip and of the tube. A wire-operated cylindrical knife is reciprocable within the tip to sever a tissue sample that has been drawn through the wall aperture by vacuum applied from within the tube.
Even though such knife-containing tubes are believed to be the best currently available for obtaining biopsy samples, several objections have been made thereto; principally that they can be inserted only through the above-mentioned hours long technique and cannot be used with the short time exchange guide technique, and that there is no way to control the total force of the vacuum so that there is a substantial risk of rupturing the tissue wall by drawing too much tissue through the wall aperture of the tube. Furthermore, there is no positive control over operation of the cylinder knife and it is difficult to determine whether or not a tissue sample has been fully and cleanly severed.
However, a biopsy tool constructed in accordance with this invention overcomes the abovediscussed problems and is fully compatible with the exchange guide technique of insertIon.
Therefore, an object of this invention is to provide a novel tool for taking biopsy samples, especially those from the upper gastrointestinal tract.
Another object of this invention is to provide a tool of the character stated that may be quickly and simply inserted to its final position over a prepositioned exchange guide.
Another object of this invention is to provide a tool of the character stated that includes a rigid tip affixed to the distal end of a flexible intubation tube and is provided with a body portion having a longitudinal duct for the passage of an exchange guide.
Another object of this invention is to provide a tool of the character stated in which the body portion thereof is provided with a radial cavity having a flat outer end and having its inner end connected through the lumen of the tube to a source of vacuum whereby a predetermined and controllable quantity of tissue sample is drawn into the cavity.
A further object of this invention is to provide a tool of the character stated that includes a pneumatically operated knife assembly removably attached to the tip body to clearly and positively sever the tissue sample contained within the radial cavity.
A further object of this invention is to provide a tool of the character stated in which a friction-reducing tube is positioned within the lumen of the tube and extends from the proximal end of the exchange guide-receiving duct in the tip body to the proximal end of the tube to facilitate advance of the tube over the guide.
A further object of this invention is to provide a tool of the character stated in which vacuum is applied to the radial cavity through the lumen of the tube and air under positive or negative pressure is supplied to the knife assembly for reciprocation of the knife through a separate tube positioned within the lumen of the tube and extending from the proximal end of the knife assembly to the proximal end of the tube.
A further object of this invention is to provide a tool of the character stated in which the reciprocable knife is a flat spearpointed blade arranged to have its point pass across a diameter of the body cavity whereby to first pierce the tissue sample and then clearly sever same as the knife is advanced.
With these and other objects in view, the nature of which will become apparent, the invention will be more fully understood by reference to the drawings, the accompanying detailed description and the appended claims.
IN THE DRAWINGS:
FIG. I is a side elevation of an assembled unit constructed in accordance with this invention;
FIG. 2 is a top plan view of the body 'of the biopsy tool;
FIG. 3 is a transverse section taken along line 3-3 of FIG. 2;
FIG. 4 is a side elevation of the body thereof;
FIG. 5 is a left end elevation of the body thereof;
FIG. 6 is a right end elevation of the body thereof;
FIG. 7 is a top plan view of the operating cylinder;
FIG. 8 is a side elevation of the operating cylinder;
FIG. 9 is a left end elevation of the cylinder;
FIG. 10 is a top plan view of the piston and knife blade assembly;
FIG. 11 is a side elevation of the piston and knife blade assembly; and
FIG. 12 is an isometric view of the cylinder retaining split sleeve.
Referring to the drawings in detail, the invention as illustrated is embodied in a biopsy tool assembly generally designated 5 and includes a body 6 (see FIGS. 26) machined from solid rod stock and having a rounded distal end 7 and a flanged proximal end 8 adapted to be secured within the distal end of a long flexible plastic catheter or intestinal intubation tube indicated at 9 by dotted lines on FIG. I.
A transverse channel 10 of rectangular cross section is machined across the top of the body 6 intermediate the ends thereof and has its flat bottom 11 forming a plane surface passing through the centerline of the body. The channel 10 is adapted to receive the knife guiding portion of an operating cylinder as will be hereinafter more fully explained. A longitudinal channel 12 of rectangular cross section is machined along the top of the body 6 at the proximal end thereof and has its flat bottom 13.l'ying ina plane slightly above that of the channel bottom 11.
The top of the distal end of the body 6 is machined to a flat surface 14 which in turn is machined to define an open-ended U-shaped pocket 15 having undercut lateral walls 16 to receive and guide the lateral edges of a knife blade as will be hereinafter more fully described.
A cylindrical cavity 17 for receiving and retaining a biopsy sample extends downwardly from the surface 14 and terminates at a plane slightly below that containing the centerline of the body 6. A short radial duct 18, located adjacent the wall of the cavity 17, has its upper end in open communication with the cavity and its lower end in open communication with a longitudinal duct 19 extending therefrom to the proximal end of the body 6. A fitting 20 is affixed within the proximal end of the duct 19 for connection through tubing (not shown) to a source of vacuum so that a biopsy sample may be drawn into the cavity "when the tool has become properly positioned within a patient.
A duct 21 is disposed in spaced parallel relation to the duct 19 and extends the full length of the body 6 to permit passage of an exchange guide therethrough. The proximal end of the duct 21 is provided with a fitting 22 for connection with the distal end of a friction-reducing tubular sheath (not shown) so that the tool and its associated intubation tube 9 may be more readily advanced over the exchange guide.
The body 6 also carries a pneumatically operable knife to sever the biopsy sample that has been drawn into the cavity 17. To this end (see FIGS. 7, 8 and 9) a cylinder having a generally hemicylindrical distal portion 23 and a tubular proximal extension 24, is fitted in the transverse and.longitudinal channels and 12 and is provided with a horizontal knife receiving and guiding slot 25, the bottom of which is coplanar with the bottom of the U-shaped pocket 15. The upper portion of the distal end portion 23 is bevelled as at 26 to reduce resistence when the tool is being inserted into a patient.
A cylindrical piston 27 is reciprocable within the bore of the cylinder 24 and is provided at its distal end with a flat knife blade 28 having a double bevel spear point cutting edge 29.
The cylinder and knife assembly is removably retained within the body 6 by a sleeve 30 (see FIG. I and 12) having a longitudinal split 31 of a width somewhat greater than the outside diameter of the tubular extension 24 so that when the sleeve is rotated until the split 31 is aligned therewith, the entire cylinder and knife assembly may be readily removed for cleaning and for replacement of the knife whenever it becomes too dull for further use. The proximal end 8 of the body 6 is provided with a round-headed stud 32 that is received within the split 31 when the sleeve 30 has been rotated to its cylinder-securing position. Springiness of the sleeve 30 permits the edge of the split 31 to ride up over the stud 32 when the sleeve is rotated.
A fitting 33 is affixed to the proximal end of the tubular extension 24 for connection through suitable tubing to an air syringe (not shown) for actuation of the piston 27 and its knife blade 28. Advancement of the plunger of the syringe will compress air to effect advancement of the knife to sever the tissue sample that has been drawn into the cavity 17, and withdrawal of the syringe plunger will create a vacuum to retract the knife. After the knife has thus been reciprocated one or two times, it is again advanced to cover the cavity 17 and the biopsy sample contained therein and is kept in this advanced position until the tool has been withdrawn from the patient, thus assuring retention of the sample and preventing it from being contaminated during withdrawal of the tool.
It will be appreciated from the foregoing description that the biopsy tool of this invention must be quite small, otherwise it would not be readily insertable throughthe designated internal passages. Typically, the body 6 would have an outside diameter in a range ofO. 10 inch to 0.65 inch, preferably about 0.25 inch and a length in a range of 0.30 inch to 2.0 inch,
preferabl about0.75 inch. h I
Thus I will be seen that this invention provides a novel biopsy tool in which a tissue sample is vacuum displaced within a cavity of fixed volume and severed by a reciprocable knife that can be actuated to close the sample-containing cavity as the tool is withdrawn. 7
It is, of course, to be understood that variations in arrangement and proportions of parts may be made within the scope of the appended claims.
1. A biopsy tool comprising a generally cylindrical body having a smoothly rounded distal end, a proximal end and a longitudinal axis, a plane surface extending proximally from the distal end of said body, a sample-receiving cavity extending into said body from said plane surface, aflat-bladed knife reciprocable across said cavity along said surface, knife actuating means adjacent to said surface, a first bore extending axially from end-to-end of the body and open at both ends, and a second bore extending axially from the proximal end of the body to a point adjacent said cavity and being in communication with said cavity.
2. A biopsy tool according to claim 1 in which said surface lies parallel to said axis and said knife is reciprocable axially.
3. A biopsy tool according to claim 1 in which the knife actuating means includes a piston fixed to the knife, a cylinder adapted to receive said piston and a fitting for connection of the cylinder to a source of actuating fluid.
4. A biopsy tool according to claim 3 in which the cylindrical body is longitudinally recessed adjacent its proximal end, the cylinder is formed in the distal end of a separate cylinder block, said block is fitted in said longitudinal recess, and which includes releasable means for holding said block in said recess.
5. A biopsy tool according to claim 4 in which said releasable means is a rotatable collar.
6. A biopsy tool according to claim 2 in which the knife has parallel sides and a double bevel spear point cutting edge, the distance between said sides being greater than the corresponding dimension of the sample-receiving cavity.
7. A biopsy tool according to claim 6 in which the plane surface is bounded by a U-shaped rim around the distal and lateral edges of said surface, the lateral portions of said rim being parallel and spaced to guide freely the parallel sides of the knife.
8. A biopsy tool according to claim 4 in which the cylinder block is provided with a distally extending portion slotted in a plane parallel to the axis of the cylinder, the knife being slidable in said slot.
9. A biopsy tool according to claim 1 which includes a fitting at the proximal end of said second bore for connection thereof to a source of vacuum.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2212133 *||May 4, 1937||Aug 20, 1940||Fred J Melges||Surgical instrument|
|US2684069 *||Jul 5, 1952||Jul 20, 1954||Donaldson||Precision linear-fracture instrument for heart valve surgery|
|US2708437 *||Mar 31, 1952||May 17, 1955||Elizabeth Painter Hutchins||Surgical instrument|
|US3033194 *||Nov 8, 1960||May 8, 1962||Lippert Henry E||Biopsy capsule and apparatus|
|US3253524 *||Jan 2, 1963||May 31, 1966||Olympus Optical Co||Flexible tube assembly|
|US3289669 *||Feb 25, 1964||Dec 6, 1966||Dwyer Donald J||Biopsy capsule arrangement|
|US3401684 *||Dec 16, 1965||Sep 17, 1968||Weck & Co Edward||Biopsy capsules|
|FR1451726A *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4620547 *||Dec 28, 1984||Nov 4, 1986||Richard Wolf Gmbh||Instrument for sampling tissue specimens|
|US4781202 *||Aug 31, 1987||Nov 1, 1988||Janese Woodrow W||Biopsy cannula|
|US5526822 *||Mar 24, 1994||Jun 18, 1996||Biopsys Medical, Inc.||Method and apparatus for automated biopsy and collection of soft tissue|
|US5542432 *||Feb 1, 1994||Aug 6, 1996||Symbiosis Corporation||Endoscopic multiple sample bioptome|
|US5649547 *||Feb 10, 1995||Jul 22, 1997||Biopsys Medical, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US5665099 *||May 12, 1995||Sep 9, 1997||Pilo; Giuseppe||Surgical scalpel with automatically retractable blade|
|US5674232 *||Sep 20, 1996||Oct 7, 1997||Halliburton; Alexander George||Catheter and method of use thereof|
|US5775333 *||May 13, 1996||Jul 7, 1998||Ethicon Endo-Surgery, Inc.||Apparatus for automated biopsy and collection of soft tissue|
|US5810744 *||Nov 18, 1997||Sep 22, 1998||Boston Scientific Corporation||Instrument for collecting multiple biopsy specimens|
|US5817115 *||Dec 4, 1995||Oct 6, 1998||Chiron Vision Corporation||Apparatus for resecting corneal tissue|
|US5860993 *||Sep 25, 1996||Jan 19, 1999||Medworks Corp.||Suture cutter|
|US5871453 *||Aug 29, 1996||Feb 16, 1999||Boston Scientific Corporation||Moveable sample tube multiple biopsy sampling device|
|US5895370 *||Jan 7, 1997||Apr 20, 1999||Vidamed, Inc.||Medical probe (with stylets) device|
|US5897507 *||Nov 25, 1996||Apr 27, 1999||Symbiosis Corporation||Biopsy forceps instrument having irrigation and aspiration capabilities|
|US5928164 *||Jan 9, 1998||Jul 27, 1999||Ethicon Endo-Surgery, Inc.||Apparatus for automated biopsy and collection of soft tissue|
|US5944673 *||May 14, 1998||Aug 31, 1999||Ethicon Endo-Surgery, Inc.||Biopsy instrument with multi-port needle|
|US5951488 *||Dec 3, 1996||Sep 14, 1999||Symbiosis Corporation||Endoscopic multiple sample bioptome|
|US5964716 *||May 14, 1998||Oct 12, 1999||Ethicon Endo-Surgery, Inc.||Method of use for a multi-port biopsy instrument|
|US5980469 *||Jan 9, 1998||Nov 9, 1999||Ethicon Endo-Surgery, Inc.||Method and apparatus for automated biopsy and collection of soft tissue|
|US6017316 *||Jun 18, 1997||Jan 25, 2000||Biopsys Medical||Vacuum control system and method for automated biopsy device|
|US6019733 *||Sep 18, 1998||Feb 1, 2000||United States Surgical Corporation||Biopsy apparatus and method|
|US6050955 *||Sep 18, 1998||Apr 18, 2000||United States Surgical Corporation||Biopsy apparatus and method|
|US6053877 *||Nov 17, 1998||Apr 25, 2000||Boston Scientific Corporation||Movable sample tube multiple biopsy sampling device|
|US6077230 *||May 14, 1998||Jun 20, 2000||Ethicon Endo-Surgery, Inc.||Biopsy instrument with removable extractor|
|US6142955 *||Feb 20, 1998||Nov 7, 2000||United States Surgical Corporation||Biopsy apparatus and method|
|US6142956 *||Feb 3, 1997||Nov 7, 2000||Symbiosis Corporation||Proximal actuation handle for a biopsy forceps instrument having irrigation and aspiration capabilities|
|US6142957 *||Jan 27, 1997||Nov 7, 2000||Boston Scientific Corporation||Multiple biopsy sampling device|
|US6174292||Feb 24, 1999||Jan 16, 2001||Symbiosis Corporation||Biopsy forceps instrument having irrigation and aspiration capabilities|
|US6193671||May 4, 1998||Feb 27, 2001||Symbiosis Corporation||Endoscopic multiple sample bioptome with enhanced biting action|
|US6193673||Feb 19, 1999||Feb 27, 2001||United States Surgical Corporation||Biopsy instrument driver apparatus|
|US6206847 *||Mar 17, 1999||Mar 27, 2001||Vidamed, Inc.||Medical probe device|
|US6231522||Feb 18, 2000||May 15, 2001||Ethicon Endo-Surgery, Inc.||Biopsy instrument with breakable sample segments|
|US6241687||Feb 18, 2000||Jun 5, 2001||Ethicon Endo-Surgery, Inc.||Method of use for a biopsy instrument with breakable sample segments|
|US6402701||Mar 17, 2000||Jun 11, 2002||Fna Concepts, Llc||Biopsy needle instrument|
|US6428486||Dec 21, 2000||Aug 6, 2002||Ethicon Endo-Surgery, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US6436054||Nov 24, 1999||Aug 20, 2002||United States Surgical Corporation||Biopsy system|
|US6464661||Mar 27, 2001||Oct 15, 2002||Vidamed, Inc.||Medical probe with stylets|
|US6488636||Jun 7, 2001||Dec 3, 2002||United States Surgical Corporation||Biopsy apparatus|
|US6544194||Jun 22, 2000||Apr 8, 2003||Symbiosis Corporation||Proximal actuation handle for a biopsy forceps instrument having irrigation and aspiration capabilities|
|US6554779||Feb 16, 2001||Apr 29, 2003||United States Surgical Corporation||Biopsy instrument driver apparatus|
|US6561988||Nov 20, 2000||May 13, 2003||Symbiosis Corporation||Endoscopic multiple sample bioptome with enhanced biting action|
|US6689072||Nov 13, 2001||Feb 10, 2004||Leopold S. Kaplan||Biopsy needle instrument|
|US6712773||Sep 11, 2000||Mar 30, 2004||Tyco Healthcare Group Lp||Biopsy system|
|US6832990||Aug 27, 2002||Dec 21, 2004||Symbiosis Corporation||Biopsy instrument having aspiration capabilities|
|US6860860||Nov 19, 2001||Mar 1, 2005||Tyco Healthcare Group, Lp||Tissue sampling and removal apparatus and method|
|US6926676||Oct 16, 2001||Aug 9, 2005||Boston Scientific Scimed, Inc.||Biopsy instrument having irrigation and aspiration capabilities|
|US7189207||May 23, 2003||Mar 13, 2007||Tyco Healthcare Group Lp||Biopsy system having a single use loading unit operable with a trocar driver, a knife driver and firing module|
|US7204811||Jul 7, 2004||Apr 17, 2007||Boston Scientific Miami Corporation||Proximal actuation handle for a biopsy forceps instrument having irrigation and aspiration capabilities|
|US7226424||Feb 11, 2003||Jun 5, 2007||Ethicon Endo-Surgery, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US7297121||Jun 13, 2005||Nov 20, 2007||Boston Scientific Scimed, Inc.||Biopsy instrument having irrigation and aspiration capabilities|
|US7297147 *||Mar 9, 2006||Nov 20, 2007||Gary Karlin Michelson||Method for cutting bone or cartilage with a rongeur|
|US7347828||Oct 16, 2001||Mar 25, 2008||Boston Scientific Miami Corporation||Suction adapter for medical instrument|
|US7513877||Jun 3, 2004||Apr 7, 2009||Tyco Healthcare Group Lp||Tissue sampling and removal apparatus and method|
|US7588545||Sep 10, 2003||Sep 15, 2009||Boston Scientific Scimed, Inc.||Forceps and collection assembly with accompanying mechanisms and related methods of use|
|US7591790||Jul 30, 2007||Sep 22, 2009||Stryker Puerto Rico Limited||Micro-invasive device|
|US7648466||Oct 24, 2007||Jan 19, 2010||Ethicon Endo-Surgery, Inc.||Manually rotatable piercer|
|US7762960||Jul 27, 2010||Boston Scientific Scimed, Inc.||Biopsy forceps assemblies|
|US7794411||Sep 14, 2010||Devicor Medical Products, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US7833167||Nov 16, 2010||Boston Scientific Miami Corporation|
|US7909850||Dec 28, 2005||Mar 22, 2011||Boston Scientific Scimed, Inc.||Forceps for medical use|
|US7918803||Aug 4, 2009||Apr 5, 2011||Devicor Medical Products, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US7922723 *||Apr 12, 2011||Gary Karlin Michelson||Method for using a surgical rongeur|
|US7942896||May 17, 2011||Scimed Life Systems, Inc.||Forceps and collection assembly and related methods of use and manufacture|
|US7981050||Jul 19, 2011||Devicor Medical Products, Inc.||Methods and devices for automated biopsy and collection of soft tissue|
|US8083686||Aug 5, 2009||Dec 27, 2011||Boston Scientific Scimed, Inc.||Forceps and collection assembly with accompanying mechanisms and related methods of use|
|US8128577||Jan 16, 2007||Mar 6, 2012||Tyco Healthcare Group Lp||Biopsy system|
|US8241290||Apr 12, 2011||Aug 14, 2012||Michelson Gary K||Surgical rongeur|
|US8317726||Nov 27, 2012||Boston Scientific Scimed, Inc.||Biopsy forceps assemblies|
|US8439940||Dec 22, 2010||May 14, 2013||Cabochon Aesthetics, Inc.||Dissection handpiece with aspiration means for reducing the appearance of cellulite|
|US8460205||Nov 29, 2011||Jun 11, 2013||Boston Scientific Scimed, Inc.||Forceps and collection assembly with accompanying mechanisms and related methods of use|
|US8518069||May 25, 2010||Aug 27, 2013||Cabochon Aesthetics, Inc.||Dissection handpiece and method for reducing the appearance of cellulite|
|US8591435||Mar 11, 2011||Nov 26, 2013||Devicor Medical Products, Inc.||Methods and devices for biopsy and collection of soft tissue|
|US8672859||Oct 23, 2012||Mar 18, 2014||Boston Scientific Scimed, Inc.||Biopsy forceps assemblies|
|US8790276||Mar 14, 2013||Jul 29, 2014||Devicor Medical Products, Inc.||Methods and devices for biopsy and collection of soft tissue|
|US8808199||Mar 14, 2013||Aug 19, 2014||Devicor Medical Products, Inc.||Methods and devices for biopsy and collection of soft tissue|
|US8894678||May 29, 2014||Nov 25, 2014||Ulthera, Inc.||Cellulite treatment methods|
|US8900261||May 29, 2014||Dec 2, 2014||Ulthera, Inc.||Tissue treatment system for reducing the appearance of cellulite|
|US8900262||May 29, 2014||Dec 2, 2014||Ulthera, Inc.||Device for dissection of subcutaneous tissue|
|US8906054||May 29, 2014||Dec 9, 2014||Ulthera, Inc.||Apparatus for reducing the appearance of cellulite|
|US8920452||May 29, 2014||Dec 30, 2014||Ulthera, Inc.||Methods of tissue release to reduce the appearance of cellulite|
|US8979881||May 29, 2014||Mar 17, 2015||Ulthera, Inc.||Methods and handpiece for use in tissue dissection|
|US9005229||Dec 12, 2012||Apr 14, 2015||Ulthera, Inc.||Dissection handpiece and method for reducing the appearance of cellulite|
|US9011473||Dec 12, 2012||Apr 21, 2015||Ulthera, Inc.||Dissection handpiece and method for reducing the appearance of cellulite|
|US9039722||Feb 27, 2013||May 26, 2015||Ulthera, Inc.||Dissection handpiece with aspiration means for reducing the appearance of cellulite|
|US9044259||Dec 22, 2014||Jun 2, 2015||Ulthera, Inc.||Methods for dissection of subcutaneous tissue|
|US9078688||Dec 22, 2014||Jul 14, 2015||Ulthera, Inc.||Handpiece for use in tissue dissection|
|US9179928||Aug 2, 2013||Nov 10, 2015||Ulthera, Inc.||Dissection handpiece and method for reducing the appearance of cellulite|
|US9226757||Jun 28, 2011||Jan 5, 2016||Globus Medical, Inc.||Bone removal instrument|
|US9241692||Apr 28, 2011||Jan 26, 2016||Sanovas, Inc.||Pressure/vacuum actuated catheter forceps|
|US9248317||Jun 29, 2007||Feb 2, 2016||Ulthera, Inc.||Devices and methods for selectively lysing cells|
|US9272124||Nov 7, 2014||Mar 1, 2016||Ulthera, Inc.||Systems and devices for selective cell lysis and methods of using same|
|US20020029006 *||Oct 16, 2001||Mar 7, 2002||Scimed Life Systems, Inc.||Biopsy instrument having irrigation and aspiration capabilities|
|US20020107457 *||Oct 16, 2001||Aug 8, 2002||Francese Jose L.||Suction adapter for medical instrument|
|US20030216740 *||Jun 9, 2003||Nov 20, 2003||Gary Karlin Michelson||Method for using a surgical rongeur|
|US20040019299 *||Feb 11, 2003||Jan 29, 2004||Ritchart Mark A.||Methods and devices for automated biopsy and collection of soft tissue|
|US20040059254 *||Sep 22, 2003||Mar 25, 2004||Stryker Puerto Rico Limited||Micro-invasive breast biopsy device|
|US20050054945 *||Sep 10, 2003||Mar 10, 2005||Scimed Life Systems, Inc||Forceps and collection assembly with accompanying mechanisms and related methods of use|
|US20050080441 *||Oct 10, 2003||Apr 14, 2005||Duke University||Surgical instruments which are especially useful for ophthalmic surgical procedures, and methods of making the same|
|US20050209530 *||May 20, 2005||Sep 22, 2005||Stryker Puerto Rico Limited||Micro-invasive tissue removal device|
|US20050245841 *||Jun 13, 2005||Nov 3, 2005||Vincent Turturro||Biopsy instrument having irrigation and aspiration capabilities|
|US20060100492 *||Oct 28, 2005||May 11, 2006||Medtronic, Inc.||Intra-esophageal catheter|
|US20060129185 *||Dec 28, 2005||Jun 15, 2006||Boston Scientific Scimed, Inc.||Forceps for medical use|
|US20060149271 *||Mar 9, 2006||Jul 6, 2006||Michelson Gary K||Method for cutting bone or cartilage with a rongeur|
|US20060167377 *||Mar 24, 2006||Jul 27, 2006||Ritchart Mark A||Methods and devices for automated biopsy and collection of soft tissue|
|US20070255172 *||Jun 5, 2007||Nov 1, 2007||Stryker Puerto Rico Limited||Micro-invasive nucleotomy device and method|
|US20070270709 *||Mar 20, 2007||Nov 22, 2007||Boston Scientific Miami Corporation|
|US20080132804 *||Oct 24, 2007||Jun 5, 2008||Stephens Randy R||Remote Thumbwheel For Surgical Biopsy Device|
|US20080154151 *||Oct 31, 2007||Jun 26, 2008||Ritchart Mark A||Methods and Devices for Automated Biopsy and Collection of Soft Tissue|
|US20090299219 *||Dec 3, 2009||Stryker Puerto Rico Limited||Micro-invasive device|
|US20100063415 *||Aug 4, 2009||Mar 11, 2010||Ritchart Mark A||Methods and devices for automated biopsy and collection of soft tissue|
|US20100152663 *||Feb 19, 2010||Jun 17, 2010||Darr Allan J||Stylet for bilumenal flexible medical device|
|US20110028898 *||Aug 6, 2010||Feb 3, 2011||Cabochon Aesthetics, Inc.||Dissection handpiece and method for reducing the appearance of cellulite|
|US20110160611 *||Jun 30, 2011||Devicor Medical Products, Inc.||Methods and devices for biopsy and collection of soft tissue|
|US20110190773 *||Aug 4, 2011||Gary Karlin Michelson||Surgical rongeur|
|EP0647121A1 *||Jun 15, 1993||Apr 12, 1995||MANN, David||Apparatus and method to obtain arterial biopsies|
|EP0751744A1 *||Mar 20, 1995||Jan 8, 1997||Biopsys Medical, Inc.||Method and apparatus for automated biopsy and collection of soft tissue|
|EP1031320A1 *||Jun 15, 1993||Aug 30, 2000||MANN, David||Method for obtaining an arterial biopsy|
|EP2382923A1||Apr 28, 2011||Nov 2, 2011||Sanovas Inc.||Pressure/vaccum actuated biopsy device|
|WO1994028803A1 *||Jun 10, 1994||Dec 22, 1994||Hec Medical Arts Ltd.||Catheter and method of use thereof|
|WO1999007288A1||Aug 8, 1997||Feb 18, 1999||Endonetics, Inc.||Multiple sample biopsy forceps|
|U.S. Classification||600/565, 606/171|
|International Classification||A61B17/30, A61B10/00, A61B17/00, A61B10/02, A61B17/22, A61B10/04|
|Cooperative Classification||A61B17/320783, A61B2017/00535, A61B2017/306, A61B10/04|