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Publication numberUS3595531 A
Publication typeGrant
Publication dateJul 27, 1971
Filing dateNov 4, 1969
Priority dateNov 4, 1969
Publication numberUS 3595531 A, US 3595531A, US-A-3595531, US3595531 A, US3595531A
InventorsStarnes Charles J, Williams Alan J
Original AssigneeDow Chemical Co
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Mixer apparatus
US 3595531 A
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Description  (OCR text may contain errors)

United States Patent l l l I 3,595,533 I [72] lnvc mors Alan J. Williams; [56] References Cited Charles .I. Starnes, both of Midland, Mich. UNITED STATES PATENTS "P 8733 2,518,758 8/1950 Cook 259 010. 46 2,999,673 9/l96l Kessler 259/010. 46 Paemd My 3 520 51s 7/1970 Knedlik 259/7 [73] Assignee The Dow Chemical Company Midland, Mich. Primary ExaminerWilliam 1. Price Assistant Examiner-Philip R. Coe Attorneys-Griswold & Burdick and Earl D. Ayers ABSTRACT: This invention relates to apparatus for use in indicatin the presence of substances in a small stream of liquid, [54] APPAMTus and pa rticularly to mixing apparatus for use in connection 6 clmms 2 Drawmg with chromatographic apparatus utilizing microcolumns. [52] US. Cl 259/7, The apparatus is a spherical chamber having a close-fitting 259/DlG. 46 ball therein, a pair of inputs and an output. The ball is non- [5l] Int. Cl B01! 7/02, reactive with the materials to be mixed and has a magnet em- BOlf 13/08 bedded therein. The sphere is in two parts to permit easy [50] Field of Search 259/DIG. cleaning and/or replacement of the ball. External magnetic 46, 7, 5, 8;'4l6/3 means cause rotation of the ball.

MIXER APPARATUS BACKGROUND OF THE INVENTION This invention relates to apparatus for use in indicating the presence of substances in a small stream of liquid, and particularly to mixing apparatus for use in connection with liquid chromatographic apparatus utilizing microcolumns.

in many automated organic analysis systems the effluent stream from a chromatographic column is mixed with an excess of indicator salt solution delivered at a constant rate. When so-called microcolumns are used in the chromatographic apparatus, special problems occur in mixing the salt (or other) solution with the effluent stream.

For example, the amount of column effluent representing any one substance is very small and often is not widely separated from that part of the effluent representing other materials.

Thus, difficulty has been encountered when mixing the effluent and indicator in that the volume of material either results in a great amount of indicator for a small amount of effluent or the inventory in the mixer results in the effiuent representing more than one 'material being present in the mixer.

.Accordingly, a principal object of this invention is to provide improved apparatus for mixing small volumes of materials.

Another object of the invention is to provide improved, low inventory volume mixing apparatus.

A further object of this invention is to provide improved, easy to assemble apparatus for mixing small volumes of material.

in accordance with this invention there is provided a two part housing having a spherical inner chamber.

A sphere having magnetic means disposed therein fits closely but slidably in the chamber. A pair of input means and an output means spaced from the input means communicate with the chamber.

The chamber and the sphere are nonreactive with the materials to be mixed. The sphere is rotated by means of an externally disposed rotating magnetic field.

Because of the close spacing between the sphere and the chamber walls, only a few microliters of liquid inventory occurs and excellent mixing is accomplished.

The invention, as well as additional objects and advantages thereof, may best be understood when the following detailed description is read in connection with the accompanying drawing, in which:

FIG. lis a diagrammatical view of chromatographic apparatus incorporating this invention, and

FIG. 2 is a side elevational view, partly broken away and in section, of mixing apparatus in accordance with this invention.

Referring to the drawing, and particularly to FIG. I, there is shown chromatographic apparatus including a chromatographic column 10, a reservoir or source of material to beanalyzed 12, and a feed tube 14 and pump 16 coupledbetween the reservoir 12 and the top of the column 10.

A tube 18 is coupled between the output or bottom of the column and a mixer, indicated generally by the numeral 30. A source of indicator material 20 is coupled through a constant volume pump 24 and tube 22 to the mixer 30.

The output of the mixer 30 is coupled through the tube 32 to a detector 34. A line 36 goes to waste or liquid utilization means from the output of the detector.

The output of the detector, an electrical signal, is coupled are se arated. The mating groun to provide a liqui tight seal and the parts 38, 40 are sealed together usually by a shrink-fitted adhesive strip 42.

The sphere 44, made of polytetrafluorethylene, for example, has magnetic means 46, such as a bar magnet, disposed within it.

A motor 48, mounted on a base 50 adjacent to the mixer 30, has a'magnet 52 fixedly coupled to the rotatable shaft of the motor. i

In operation, with the effiuent of the column 10 being fed directly to the mixer 30 along with indicator liquid from the reservoir 20, the rotation of the magnet 52 by meanspf the motor 12 causes a rotating magnetic field which induces rotation of the sphere 44 in the chamber 54.

The liquid is subjected to a shearing action caused by the rotation of the sphere 44, causing excellent mixing of the effluent and the indicator liquid, yet the liquid inventory in the mixer is only of the order of a few microliters.

The detector used with one apparatus in accordance with this invention may be a Gilford Monitor or other suitable spectrophotometer, for example.

It has also been 'foundthat mixing devices made in accordance with this invention either greatly reduce or eliminate the pulsations due to the pumping systems, thus offering more constant flow.

Because the mixer may be closely coupled to the output of the chromatographic column and to the detector, and because of the small inventoryin the mixer, (see FIG. 2), sharper, better defined output of the instrument may be obtained.

What I claim is:

1. Apparatus for mixing very small volumes of fluids, comprising a two part body which, when the parts are joined in operative relationship, has a spherical chamber therein, a spherical element having magnetic means incorporated therein, said element having a diameter such that it fits closely but loosely slidably within said spherical chamber, said eleme'nt being made of a material which is nonreactive with materials to be mixed in said apparatus, means for introducing materials to be mixed to said chamber, means remote from said means for introducing materials for withdrawing mixed materials from said chamber, means for joining said body parts together in a fluidtight manner, and means for imposing a moving magnetic field on said spherical element to induce rotation thereof.

2. Apparatus in accordance with claim 1, wherein said body is made of a vitreous material.

3. Apparatus in accordance with claim 1, wherein said body parts having mating ends with a hemispherially shaped surface extending inwardly therefrom, said parts being joined at said mating ends.

4. Apparatus in accordance with claim 1, wherein said means for imposing a moving magnetic field comprises a rotatable magnet disposed adjacent to said body part.

5. Apparatus in accordance with claim 1, wherein said magnetic means in said spherical element is a bar magnet.

6. Apparatus in accordance with claim 1, wherein said means for joining said body parts together comprises a fluid impervious tightly adhering tapelike element.

edges of the two parts 38, 40 are

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2518758 *Jun 22, 1949Aug 15, 1950George B CookMagnetic stirring apparatus
US2999673 *Aug 5, 1959Sep 12, 1961Technicon InstrLiquid mixing means
US3520518 *Aug 12, 1968Jul 14, 1970Omar Knedlik Enterprises IncFluid blending pump
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3862442 *May 18, 1972Jan 21, 1975David Vernon JElectric motor orbitor structure
US4876069 *Oct 27, 1986Oct 24, 1989Siegfried JochimsenBlood clotting time measuring apparatus
US4882062 *Apr 29, 1988Nov 21, 1989Rainin Instrument Co., Inc.Compact, reliable, permitting manual access
US6382827 *Nov 1, 2000May 7, 2002Dade Behring Inc.Method and apparatus for mixing liquid solutions using a rotating magnet to generate a stirring vortex action
US6461034 *Nov 14, 2001Oct 8, 2002V & P Scientific, Inc.Use of a bubble paddle tumble stirrer to mix the contents of a vessel while the contents are being removed
US6467946 *Apr 24, 2001Oct 22, 2002Dade Microscan Inc.Method and apparatus for mixing liquid samples in a container using rotating magnetic fields
US6471392 *Mar 7, 2001Oct 29, 2002Holl Technologies CompanyMethods and apparatus for materials processing
US6723999May 10, 2001Apr 20, 2004Holl Technologies CompanyElectromagnetic wave assisted chemical processing
US6742774Jun 27, 2001Jun 1, 2004Holl Technologies CompanyProcess for high shear gas-liquid reactions
US6752529Oct 3, 2002Jun 22, 2004Holl Technologies CompanyMethods and apparatus for materials processing
US6787246Oct 5, 2001Sep 7, 2004Kreido LaboratoriesManufacture of flat surfaced composites comprising powdered fillers in a polymer matrix
US6830806Apr 11, 2002Dec 14, 2004Kreido LaboratoriesMethods of manufacture of electric circuit substrates and components having multiple electric characteristics and substrates and components so manufactured
US6938687Oct 3, 2003Sep 6, 2005Holl Technologies CompanyApparatus for transfer of heat energy between a body surface and heat transfer fluid
US6994330May 28, 2004Feb 7, 2006Kriedo LaboratoriesProcess for high shear gas-liquid reactions
US7098360Jul 16, 2002Aug 29, 2006Kreido LaboratoriesProcesses employing multiple successive chemical reaction process steps and apparatus therefore
US7165881Sep 11, 2003Jan 23, 2007Holl Technologies CorporationMethods and apparatus for high-shear mixing and reacting of materials
US7538237May 28, 2004May 26, 2009Kreido Laboratoriesgas-in-liquid emulsion in a reactor to continuously process relatively large quantities of materials; hydrogen peroxide synthesis by reacting a solution of DI H2O with oxygen and hydrogen gases; p-xylene oxidation by reacting p-xylene in water with oxygen
US7718072Apr 25, 2003May 18, 2010Abbott Laboratoriesautomated pipettes; for particles suspended in fluid; nucleic acid isolation
US8211301Mar 4, 2010Jul 3, 2012Abbott LaboratoriesStructure and method for handling magnetic particles in biological assays
US8398838 *Oct 10, 2008Mar 19, 2013Wealtec Bioscience Co., Ltd.Technical measure for gel electrophoresis shaping
US8728311Jun 1, 2012May 20, 2014Abbott LaboratoryStructure and method for handling magnetic particles in biological assays
US20100089755 *Oct 10, 2008Apr 15, 2010Wealtec Bioscience Co., Ltd.Technical measure for gel electrophoresis shaping
US20130315024 *Mar 15, 2013Nov 28, 2013Halliburton Energy Services, Inc.System and Method of Mixing a Formation Fluid Sample Obtained in a Downhole Sampling Chamber
DE19963542A1 *Dec 22, 1999Sep 20, 2001Freyer ThomasMixer for medium and average viscous fluids driven by magnetic force exerted from outside mixer chamber
DE19963542C2 *Dec 22, 1999Aug 28, 2003Freyer ThomasVorrichtung zur Mischung mehrkomponentiger Fluide
EP0411068A1 *Nov 7, 1989Feb 6, 1991Applied Biosystems, Inc.Assayomate
WO1983000228A1 *Jul 2, 1982Jan 20, 1983Siegfried JochimsenApparatus for measuring the blood clotting time and method for taking and measuring the time
WO2002072251A1 *Feb 21, 2002Sep 19, 2002Richard A HollMethods and apparatus for materials processing
WO2002085505A1 *Apr 8, 2002Oct 31, 2002Dade Microscan IncMethod and apparatus for mixing liquid samples in a container using rotating magnetic fields
Classifications
U.S. Classification366/273, 366/279, 366/140
International ClassificationB01F13/08, G01N30/84, B01F13/00, G01N30/34, G01N30/00
Cooperative ClassificationG01N30/84, G01N2030/347, B01F13/0818
European ClassificationB01F13/08C, G01N30/84