|Publication number||US3604425 A|
|Publication date||Sep 14, 1971|
|Filing date||Apr 11, 1969|
|Priority date||Apr 11, 1969|
|Publication number||US 3604425 A, US 3604425A, US-A-3604425, US3604425 A, US3604425A|
|Inventors||Pierre L Le Roy|
|Original Assignee||New Research And Dev Lab Inc|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (7), Referenced by (169), Classifications (7)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patet  Inventor Pierre L. Le Roy Wilmington, Del.  Appl. No. 815,395  Filed Apr. 11,1969  Patented Sept. 14, 1971  Assignee New Research and Development Laboratories, Inc. Continuation-impart of application Ser. No. 473,055, July 19, 1965, now Patent No. 3,446,212.
 HEMOSTATIC CLIP 6 Claims, 17 Drawing Figs.
 U.S.Cl 128/325, 24/255, 128/346 [51} Int. Cl A611) 17/08, A61b 17/12  Field of Search 128/325, 334, 335, 337, 346; 24/255  References Cited UNITED STATES PATENTS 992,995 5/1911 Staples 24/255 U 3,326,217 6/1967 Kerr 128/325 3,446,212 5/1969 Le Roy. 128/325 3,509,882 5/1970 Blake 128/325 FOREIGN PATENTS 865,475 21194] France 24/3().5
1,058,094 2/1967 Great Britain.. 24/255.l
464,802 7/1951 Italy 128/337 Primary Examiner-Dalton L. Truluck AttorneyConnolly and Hutz Pmeminswmsn 3.604.425
SHEET 2 [IF 2 I'IEMOSTATIC CLIP CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation-in-part of copending application Ser. No. 473,055, filed July 19, 1965, now US Pat. No. 3,446,212 issued May 27,1969.
BACKGROUND OF INVENTION This invention relates to hemostatic clips for use in clamping wound flaps to prevent the flow of blood from severed arteries, capillaries and the like.
Applicants patent previously referred to describes and claims a highly successful hemostatic clip which is inexpensive, easily sterilized so that it can be prepackaged, disposable, adapted to be made in a variety of dimensions and can be easily applied and removed by a relatively unskilled worker. The clip disclosed in that application is essentially a tubular member having a slit completely across its body so that it can be distended from its original shape to receive the wound flap therein. As particularly disclosed in the parent application the tubular body can be distended from its original shape because of the provision of a pair of parallel slots which are disposed about 90 from the longitudinal slit whereby a plierslike applicating tool can be inserted into the slots and upon application of force thereto the longitudinal slit will be spread apart to receive the wound flap.
SUMMARY OF INVENTION An object of this invention is to provide a modified form of the above-type clip which still retains all of its advantages.
In accordance with this invention a pair of projections are disposed on the body instead of the parallel slots. The projections are connected to the body along longitudinal lines which are similarly disposed about 90 from the wound flap receiving slit. When force is applied to the projections they act as levers to spread the longitudinal slit and facilitate the insertion of the wound flap therein.
Advantageously, each projection includes a stem portion connected to the clip body and an enlarged head portion on the stem. The body may be horseshoe shaped to accommodate a greater portion of the wound flap. Furthermore the body may terminate in flanges which are perpendicular to the leg sections of the horseshoe and which have parallel undulations to provide greater traction of the wound flap while minimizing tissue damage and pain.
In another form of this invention the body is provided with a plurality of parallel peripheral slots which terminate adjacent the wound flap receiving slit whereby a longitudinal margin is formed on each side of the slit to provide stability and to control flexibility of the body. Such a clip has the advantages of greater visibility, ventilation and drainage of the wound flap and can be utilized for clamping relatively long wound flaps.
THE DRAWINGS FIG. 1 is a side view in elevation and partly in section showing a clip applied to a wound flap in accordance with one aspect of this invention;
FIG. 2 is a top plan view of the clip shown in FIG. 1;
FIG. 3 is a side view of the clip shown in FIGS. 1-2;
FIG. 4 is a bottom plan view of the clip shown in FIGS. 1-3;
FIG. 5 is an enlarged view taken through FIG. 4 along the line 5-5 and showing the clip clamping against a wound flap;
FIG. 6 is a side view of an applicator in accordance with another embodiment of this invention;
FIG. 7 is a front view ofthe applicator shown in FIG. 6;
F IG. 8 is a cross-sectional view taken through FIG. 6 along the line 88;
FIG. 9 is a plan view of a portion of the applicator shown in FIGS. 6-8;
FIGS. IO-II are side views of the applicator and its clip in different phases of operation;
FIG. 12 is a cross-sectional view taken through FIG. 11 along the line l2-l2;
FIGS. 13-15 are front, top and side views, respectively, of the clip shown in FIGS. 10-12; and
FIGS. 16-17 are side views of modified clips in accordance with this invention.
DETAILED DESCRIPTION FIGS. l-5 show a clip in accordance with one embodiment of this invention. As indicated therein clip 10 is generally of tubular form in that it is in the shape of a hollow body open at both ends. The clip can be constructed from any material possessing the required elastic modulus and physical properties. Nylon tubing for example as well as Delrin, Teflon polyethylene, polypropylene and other suitable polymers and/or plastics are particularly adapted for this invention. Additionally, thin metal tubes or other alloys are also suitable. The tubular body can be formed into a circular, rectangular, triangular, square, elliptical or other adaptable cross section having the appropriate physical properties and being clinically acceptable. As illustrated in the drawings, however, the tubular body is advantageously of generally horseshoe shape to increase its wound-flap-receiving capability.
Clip 10 may be of any desired length required by the specific purpose to which it is to be used. Some advantageous lengths for example are one-fourth, one-half, and l inch, with the longer length being suitable for large wound flaps.
Clip 10 includes a longitudinal slit 12 across its entire length so that it can be distended by for example any suitable applicator 14. Upon being distended the slit 12 is spread apart whereby the wound flap 16 can easily be inserted therein. Upon release of force from the applicator the slit edges are then applied to the two sides of wound flap 16 or other tissue to prevent the flow of blood from severed arteries, capillaries or the like. At approximately to the longitudinal slit 12 are two parallel projections 18, 18 which are longitudinally centered on the clip body. Each projection includes a stem portion 20 which, as best shown in FIG. 5, is integral with the clip body and is tangential thereto. Stem 20 actually forms an extension of the leg sections 24 of the horseshoe-shaped clip body. Stem 20 terminates in an enlarged arcuate head 22 to facilitate the reception of applicator tool 14 thereon. Projections 18 extend at least one-third of the length of the clip body to provide a sufficient area for the reception of applicator 14.
As best shown in FIG. 5 the clip body is horseshoe shaped having an arcuate bridging section 26 between projections 18 with the straight leg sections 24 connected to the bridging section. Leg sections 24 terminate in substantially perpendicular flanges 28 which are spaced from each other to form the slit 12. The flanges 28, as shown in FIG. 4, terminate in parallel undulations 30 disposed generally parallel to the longitudinal axis of the clip body with the sinusoidal teeth being generally parallel and having gently merging hills and valleys. As shown in FIG. 5 the undulations taper in a converging direction toward the slit with the inner surfaces 32 of the flanges 28 being coplanar and with the flanges terminating in blunt or rounded ends 34. This particular configuration of slit 12 is particularly effective in providing sufficient traction to the wound flap while minimizing any pain thereto or undue damage to the tissue.
Clip 10 can be easily and rapidly removed either with applicator 14 or by hand. Manual removal is accomplished by squeezing projections 18 toward each other so that the projections act as levers to spread flanges 28 away from each other. The clip 10 can then be merely slipped off the wound flap 16 without noticeable damage to the tissue. Additionally, no special training is necessary for the scrub nurse, assistant, or surgeon in applying or removing clips 10.
Other advantages of clip 10 are that it can be sterilized by either the flash or routine method employing high pressure and high temperature. Clip 10 can also be sufficiently inexpensive to be disposable and thus packaged in presterile units.
When desired or necessary, however, clips can be reused. Even if the clips are unduly abused by, for example, being dropped, the clips show no structural fatigue or cracks and maintain their elastic state to a high degree.
correspondingly, the operative maintenance of applicator 14 is minimal. Applicator 14 may for example be made of a metal which can be autoclaved and handled without any unusual difficulty.
Advantageously, clip 10 may incorporate an X-ray or radiopaque material such as barium sulfate. Accordingly, the clip can be easily located if it should be lost within the operative site. Additionally, a bacteriostatic material may be used for clip 10. Accordingly, items such as iodonated compounds and an alpha or a low energy beta emitter may be added.
As indicated above clip 10 has proven to be exceptionally effective. For example, its ease of application, the lack of tissue irritability, the ease of adjustment, and the rapid removal enable the surgeon to move more quickly on entering the operative field. Clip 10 is particularly effective with scalp and back wounds, and can also be advantageously used on abdominal or long flap wounds as may be necessary in extremity work. Moreover, the gentleness with which the blood vessels are compressed and the lack of tissue irritability are especially notable.
FIGS. 6l7 illustrate another clip 40 formed in accordance with this invention. Clip 40 is for example made of a disposable plastic material or materials previously enumerated with respect to clip 10. Clip 40 is of extended or continuous length, being at least 10 inches long, so that it can be cut to the desired size for individual application. Additionally, clip 40 is specifically designed to provide maximum ventilation and drainage of the wound as well as increased visibility thereof.
As indicated most clearly in FIGS. 1345, clip 40 is of tubular form having a suitable wall thickness and a continuous elongated longitudinal slit 42. Clip 40 may be of any length such as the medium-size clip as indicated in FIGS. 14-15 or the extra-long clip shown in FIG. 16. The border or margin on each side of slit 42 forms a pair of elongated longitudinal backbones 44 and 46. Additionally, clip 40 includes a plurality of parallel-spaced peripheral slots 48 which are separated by ribs 50 spanning backbones 44 and 46. The provision of these perforations or slots 48 not only provides visibility, ventilation, and drainage of the wound flap 52 (FIG. 11), but also permits the delicate adjustment of a balance between the clamping strength and ease of application of clip 40. The thickness of backbones 44 and 46 determines the flexibility of clip 40 and its ability to conform to any wound configurations. Thus clip 40 can be applied in a bent or curved manner, as well as in a relatively straight line.
Although slots 48 are an exceptionally effective manner of forming perforations in clip 40 it is also possible to form the perforations in other ways, as long as the perforations permit flexibility, adequate clamping force, and visibility of the wound.
One modification of clip 40 is shown in FIG. 17 in which backbones 44 and 46 are serrated along slit 42 to provide more positive traction on the wound flap.
FIGS. 6-12 illustrate the applicator 60 which is particularly adapted for clips 40. As indicated therein, applicator 60 is made of two parts. One part 62 is a relatively long support rod, one end of which may be conveniently held and used as a handle as shown in FIG. 15. The second member or part is guide rod 64. Guide rod 64 includes a feed end 66 and a discharge end 68. Discharge end 68 is secured to the remote end 70 of support rod 62 to form the dispensing end 76 of applicator 60. Members 62 and 64 are made, for example, in the form of flattened tubular elements as best shown in FIG. 16. Accordingly, a pair of grooves 72 and 74 are formed at the juncture of discharge end 68 and remote end 70. As shown in FIGS. 7 and 9 dispensing end 76 of applicator 60 tapers or widens outwardly. Thus the distance between grooves 72 and 74 also increases.
In use the tubular clip 40 is inserted around feed end 66 of guide member 64 as shown in FIG. 10. Since feed end 66 is spaced from support rod 62, clip 40 can easily be loaded around guide rod 64. Applicator 60 is then brought into the vicinity of wound flap 52. Advantageously, dispensing end 76 of applicator 60 is concave and tapered to act as a registry means for wound flap 52 so that wound flap can be inserted in the concave portion 78 and maintained in position for the application of clip 40 as most clearly shown in FIG. 15. Additionally, this registry is facilitated by the tapered end of applicator 60 in which guide member 64 projects slightly beyond support member 62.
After wound flap 52 has been brought into registry in tapered concave portion 78 clip 40 is slid down guide member 64. The end of clip 40 is open or distended by the outwardly tapering dispensing end 76 of applicator 60. Accordingly, clip 40 is simply progressively slid off applicator 60 in an open position onto flap 52.
Applicator 60 which is made of a clinically acceptable material such as steel or other metal or plastic, and can easily be held in either hand with the clip 40 being advanced by the thumb of the other hand. When the required length of clip 40 has been applied to wound flap 52, the excess clip can be cut off by, for example, a scissors. Clip 40 can thereby be easily applied in a simple sweeping fashion. Thus for example for the first time a large area can be clamped by employing two large continuous hemostatic clips 40 by using only two maneuvers, in contrast to the multiple repeated maneuvers which have been required with conventional small clamps. In addition to the above noted advantages of ease of application and removal of clip 40, the clip also renders the operative area free of clutter.
For removal, clip 40 can be fractionally withdrawn from wound flap 52 to allow for surgical closure by interrupted sutures for controlling hemostasis and approximation of tissue planes. This can be done manually, without requiring an instrument, as is ordinarily necessary for conventional clips. Alternatively, the clip 40 can be removed in one sweeping motion, if necessary, rather than fractionally or with the conventional multiple actions.
1. A hemostatic clip comprising a body in the form of an elongated tubular element, said tubular element having an ellipsoidal cross section, wound-flap-engaging means on said body, said wound-flap-engaging means being an elongated longitudinal slit extended completely across said body whereby said body may be distended from its original shape, a pair of outwardly extending projections connected to said body remote from said slit for accommodating a force-applying tool, said body being resiliently urged to maintain its original tubular shape whereby the original tubular shape of said body may be distended upon application of force to said projections to cause said slit to widen and permit the insertion of a wound flap therein and said body will return toward its original undistended tubular shape upon cessation of the application of force for firmly engaging the wound flap, said slit being defined by a pair of longitudinal edges, and said edges being shaped as sinusoidal teeth having gently merging hills and valleys and wherein said teeth taper outwardly away from said edges, said teeth being defined in cross section by an inner wall disposed toward the interior of said tubular body, said inner walls of said teeth being generally aligned, and each outer wall being inclined from its edge where it merges with its inner wall outwardly away from its inner wall.
2. A clip as set forth in claim 1 wherein said body is made of a polymer material.
3. A clip as set forth in claim 2 wherein the sinusoidal curvatures of said teeth are generally parallel.
4. A clip as set forth in claim 3 wherein each of said projections is joined to said body along a longitudinal line disposed about from said longitudinal slit, each of said projections comprising a stem portion connected to said body and a head portion connected to said stern portion, said stern portion and body may be distended from its original shape, a plurality of parallel peripheral slots being in said body and terminating adjacent said longitudinal slit with a longitudinal margin on each side of said slit forming a thin backbone to provide stability and to control the flexibility of said body, and said body being at least 10 inches long and being axially bendable for clamping a relatively long wound flap.
6 A clip as set forth in claim 5 wherein the edges of said slit are serrated to provide positive traction on the wound flap.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US992995 *||Sep 23, 1910||May 23, 1911||Augustine E Staples||Cow-tail holder.|
|US3326217 *||Apr 27, 1964||Jun 20, 1967||Sydney Kerr Harry||Hemostatic clamp|
|US3446212 *||Jul 19, 1965||May 27, 1969||New Research & Dev Lab Inc||Hemostatic clip and applicator therefor|
|US3509882 *||Sep 18, 1967||May 5, 1970||American Hospital Supply Corp||Parallel jaw spring clip and applicator|
|FR865475A *||Title not available|
|GB1058094A *||Title not available|
|IT464802A *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3863301 *||Dec 29, 1972||Feb 4, 1975||Leveen Harry H||Elastic bandage and fastener therefor|
|US4177818 *||Dec 5, 1977||Dec 11, 1979||Pedro Francisco L De||Self attachable small-toothed electrode and a forceps for maneuvering it|
|US4217902 *||Nov 14, 1978||Aug 19, 1980||March Alfred L||Hemostatic clip|
|US4317451 *||Feb 19, 1980||Mar 2, 1982||Ethicon, Inc.||Plastic surgical staple|
|US4340061 *||Oct 25, 1977||Jul 20, 1982||Mayfield Education And Research Fund||Aneurysm clip|
|US4416266 *||May 15, 1981||Nov 22, 1983||The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration||Medical clip|
|US4447943 *||Feb 10, 1983||May 15, 1984||The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration||Process of making medical clip|
|US4465071 *||Sep 22, 1982||Aug 14, 1984||Samuels Peter B||Method of applying skin clips|
|US4490326 *||Oct 6, 1982||Dec 25, 1984||Ethicon, Inc.||Molding process for polydioxanone polymers|
|US4506669 *||Sep 22, 1982||Mar 26, 1985||Blake Joseph W Iii||Skin approximator|
|US4586503 *||Dec 1, 1983||May 6, 1986||University Of New Mexico||Surgical microclip|
|US4612932 *||Oct 2, 1984||Sep 23, 1986||Aesculap-Werke Ag Vormals Jetter & Scheerer||Magazine for C-shaped scalp clips|
|US4637395 *||Oct 2, 1984||Jan 20, 1987||Aesculap-Werke Ag||Applicator for C-shaped scalp clips|
|US4733664 *||Oct 15, 1985||Mar 29, 1988||University Of New Mexico||Surgical clip, applier, and method|
|US4796627 *||Aug 26, 1986||Jan 10, 1989||Tucker Wilson H||Clip applicator and spreadable clips for use therein|
|US4835824 *||Apr 13, 1988||Jun 6, 1989||Durham Vaughn L||Medical clamp|
|US4929239 *||Feb 5, 1988||May 29, 1990||Aesculap-Werke Ag Vormals Jetter & Scheerer||Device for filling the magazine of a scalp clip applicator with C-shaped scalp clips|
|US5147306 *||Jul 1, 1991||Sep 15, 1992||Gubich Stephen J||Device for puckering the flesh to facilitate injections|
|US5207692 *||Jul 30, 1990||May 4, 1993||Codman & Shurtleff, Inc.||Surgical clip applier with reciprocating clip sleeve and dual ratchet mechanism|
|US5366458 *||Dec 13, 1990||Nov 22, 1994||United States Surgical Corporation||Latchless surgical clip|
|US5474732 *||Jul 28, 1994||Dec 12, 1995||United States Surgical Corporation||Forming latchless surgical clip and fixture for use therein|
|US5640742 *||Dec 27, 1995||Jun 24, 1997||Temtec, Inc.||Spring badge clip|
|US5665097 *||Apr 21, 1995||Sep 9, 1997||Baker; John W.||Clip applicator|
|US5695505 *||Mar 9, 1995||Dec 9, 1997||Yoon; Inbae||Multifunctional spring clips and cartridges and applicators therefor|
|US5725542 *||Feb 27, 1997||Mar 10, 1998||Yoon; Inbae||Multifunctional spring clips and cartridges and applicators therefor|
|US5782844 *||Mar 5, 1996||Jul 21, 1998||Inbae Yoon||Suture spring device applicator|
|US5810851 *||Mar 5, 1996||Sep 22, 1998||Yoon; Inbae||Suture spring device|
|US5810853 *||Jan 16, 1996||Sep 22, 1998||Yoon; Inbae||Knotting element for use in suturing anatomical tissue and methods therefor|
|US5827306 *||Jun 13, 1997||Oct 27, 1998||Yoon; Inbae||Multifunctional spring clips and cartridges and applicators therefor|
|US5849019 *||Oct 7, 1997||Dec 15, 1998||Yoon; Inbae||Multifunctional spring clips and cartridges and applications therefor|
|US5972001 *||Jan 23, 1998||Oct 26, 1999||Yoon; Inbae||Method of ligating anatomical tissue with a suture spring device|
|US6197042||Jan 5, 2000||Mar 6, 2001||Medical Technology Group, Inc.||Vascular sheath with puncture site closure apparatus and methods of use|
|US6241740||Apr 9, 1998||Jun 5, 2001||Origin Medsystems, Inc.||System and method of use for ligating and cutting tissue|
|US6277140||Jan 16, 2001||Aug 21, 2001||Integrated Vascular Systems, Inc.||Vascular sheath with puncture site closure apparatus and methods of use|
|US6349727||May 25, 2000||Feb 26, 2002||Pos-T-Vac, Inc.||Penile clamp for inhibiting incontinence|
|US6391048||Jul 5, 2000||May 21, 2002||Integrated Vascular Systems, Inc.||Integrated vascular device with puncture site closure component and sealant and methods of use|
|US6461364||Apr 11, 2000||Oct 8, 2002||Integrated Vascular Systems, Inc.||Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use|
|US6527786||Jun 21, 1999||Mar 4, 2003||Origin Medsystems, Inc.||System and method of use for ligating and cutting tissue|
|US6632238||Aug 20, 2001||Oct 14, 2003||Integrated Vascular Systems, Inc.||Vascular sheath with puncture site closure apparatus and methods of use|
|US6695867||Feb 21, 2002||Feb 24, 2004||Integrated Vascular Systems, Inc.||Plunger apparatus and methods for delivering a closure device|
|US6719777||Dec 7, 2000||Apr 13, 2004||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US6749621||Feb 21, 2002||Jun 15, 2004||Integrated Vascular Systems, Inc.||Sheath apparatus and methods for delivering a closure device|
|US6780197||Dec 7, 2000||Aug 24, 2004||Integrated Vascular Systems, Inc.||Apparatus and methods for delivering a vascular closure device to a body lumen|
|US6942674||Feb 21, 2002||Sep 13, 2005||Integrated Vascular Systems, Inc.||Apparatus and methods for delivering a closure device|
|US7712190 *||Feb 18, 2004||May 11, 2010||Peter Weingartner||Clip for clipping sheets together|
|US7806904||Feb 24, 2004||Oct 5, 2010||Integrated Vascular Systems, Inc.||Closure device|
|US7806910||Jul 31, 2006||Oct 5, 2010||Abbott Laboratories||Multi-element biased suture clip|
|US7819895||Apr 18, 2006||Oct 26, 2010||Integrated Vascular Systems, Inc.||Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use|
|US7828817||Aug 4, 2005||Nov 9, 2010||Integrated Vascular Systems, Inc.||Apparatus and methods for delivering a closure device|
|US7841502||Dec 18, 2007||Nov 30, 2010||Abbott Laboratories||Modular clip applier|
|US7842068||Nov 30, 2010||Integrated Vascular Systems, Inc.||Apparatus and methods for providing tactile feedback while delivering a closure device|
|US7850709||Jun 4, 2003||Dec 14, 2010||Abbott Vascular Inc.||Blood vessel closure clip and delivery device|
|US7850797||Dec 14, 2010||Integrated Vascular Systems, Inc.||Methods for manufacturing a clip and clip|
|US7854810||Dec 17, 2003||Dec 21, 2010||Integrated Vascular Systems, Inc.||Methods for manufacturing a clip and clip|
|US7857828||Feb 1, 2005||Dec 28, 2010||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US7867249||Aug 8, 2003||Jan 11, 2011||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US7879071||May 9, 2003||Feb 1, 2011||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US7887553||Jul 8, 2002||Feb 15, 2011||Tyco Healthcare Group Lp||Right angle clip applier apparatus and method|
|US7887555||Jul 9, 2003||Feb 15, 2011||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US7887563||Jun 14, 2005||Feb 15, 2011||Abbott Vascular Inc.||Surgical staple|
|US7896895 *||Nov 23, 2005||Mar 1, 2011||Ethicon Endo-Surgery, Inc.||Surgical clip and applier device and method of use|
|US7896896||Mar 1, 2011||Tyco Healthcare Group Lp||Endoscopic surgical clip|
|US7901428||Mar 8, 2011||Integrated Vascular Systems, Inc.||Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use|
|US7905900||Mar 15, 2011||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US7918873||Sep 18, 2006||Apr 5, 2011||Abbott Vascular Inc.||Surgical staple|
|US7931669||Apr 26, 2011||Integrated Vascular Systems, Inc.||Integrated vascular device with puncture site closure component and sealant and methods of use|
|US8048108||Feb 4, 2009||Nov 1, 2011||Abbott Vascular Inc.||Vascular closure methods and apparatuses|
|US8128644||Sep 19, 2003||Mar 6, 2012||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8182497||May 22, 2012||Integrated Vascular Systems, Inc.||Closure device|
|US8187290 *||May 29, 2012||Damage Control Surgical Technologies, Inc.||Method and apparatus for vascular and visceral clipping|
|US8192459||Jun 5, 2012||Abbott Vascular Inc.||Blood vessel closure clip and delivery device|
|US8202283||Jun 19, 2012||Integrated Vascular Systems, Inc.||Methods for manufacturing a clip and clip|
|US8202293||Jun 20, 2008||Jun 19, 2012||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US8202294||Dec 20, 2010||Jun 19, 2012||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US8226681||Jul 24, 2012||Abbott Laboratories||Methods, devices, and apparatus for managing access through tissue|
|US8236026||Aug 7, 2012||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8257390||Sep 4, 2012||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8303624||Mar 15, 2010||Nov 6, 2012||Abbott Cardiovascular Systems, Inc.||Bioabsorbable plug|
|US8313497||Nov 20, 2012||Abbott Laboratories||Clip applier and methods of use|
|US8323312||Jun 9, 2009||Dec 4, 2012||Abbott Laboratories||Closure device|
|US8372095||Feb 12, 2013||Covidien Lp||Endoscopic surgical clip|
|US8398656||Mar 2, 2011||Mar 19, 2013||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US8398676||Mar 19, 2013||Abbott Vascular Inc.||Closure device|
|US8469995||Jun 4, 2012||Jun 25, 2013||Abbott Vascular Inc.||Blood vessel closure clip and delivery device|
|US8486092||Mar 11, 2009||Jul 16, 2013||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8486108||Feb 1, 2006||Jul 16, 2013||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8518057||Sep 13, 2012||Aug 27, 2013||Abbott Laboratories||Clip applier and methods of use|
|US8529587||Jun 6, 2012||Sep 10, 2013||Integrated Vascular Systems, Inc.||Methods of use of a clip applier|
|US8556930||Jun 28, 2006||Oct 15, 2013||Abbott Laboratories||Vessel closure device|
|US8556932||May 19, 2011||Oct 15, 2013||Abbott Cardiovascular Systems, Inc.||Collapsible plug for tissue closure|
|US8579932||Feb 24, 2004||Nov 12, 2013||Integrated Vascular Systems, Inc.||Sheath apparatus and methods for delivering a closure device|
|US8585836||Jun 18, 2012||Nov 19, 2013||Integrated Vascular Systems, Inc.||Methods for manufacturing a clip and clip|
|US8590760||May 24, 2005||Nov 26, 2013||Abbott Vascular Inc.||Surgical stapler|
|US8591530||Jan 9, 2009||Nov 26, 2013||Cook Medical Technologies Llc||Suture guide clip and laparoscopic techniques|
|US8597310||Nov 29, 2010||Dec 3, 2013||Cook Medical Technologies Llc||Laparoscopic anastomosis tools and technique|
|US8597325||Nov 29, 2010||Dec 3, 2013||Integrated Vascular Systems, Inc.||Apparatus and methods for providing tactile feedback while delivering a closure device|
|US8603116||Aug 4, 2010||Dec 10, 2013||Abbott Cardiovascular Systems, Inc.||Closure device with long tines|
|US8603136||May 3, 2007||Dec 10, 2013||Integrated Vascular Systems, Inc.||Apparatus and methods for providing tactile feedback while delivering a closure device|
|US8617184||Feb 15, 2011||Dec 31, 2013||Abbott Cardiovascular Systems, Inc.||Vessel closure system|
|US8623009 *||Apr 5, 2006||Jan 7, 2014||The Brigham And Women's Hospital, Inc.||Endoscopic gastric bypass defect repair|
|US8652151||Jan 13, 2011||Feb 18, 2014||Covidien Lp||Right angle clip applier apparatus and method|
|US8657852||Mar 8, 2013||Feb 25, 2014||Abbott Vascular Inc.||Closure device|
|US8672953||Jun 6, 2011||Mar 18, 2014||Abbott Laboratories||Tissue closure system and methods of use|
|US8690910||Mar 31, 2006||Apr 8, 2014||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US8728119||Feb 18, 2011||May 20, 2014||Abbott Vascular Inc.||Surgical staple|
|US8758396||Apr 27, 2006||Jun 24, 2014||Integrated Vascular Systems, Inc.||Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use|
|US8758398||Sep 7, 2007||Jun 24, 2014||Integrated Vascular Systems, Inc.||Apparatus and method for delivering a closure element|
|US8758399||Aug 2, 2010||Jun 24, 2014||Abbott Cardiovascular Systems, Inc.||Expandable bioabsorbable plug apparatus and method|
|US8758400||Nov 8, 2010||Jun 24, 2014||Integrated Vascular Systems, Inc.||Closure system and methods of use|
|US8784447||Apr 25, 2005||Jul 22, 2014||Abbott Vascular Inc.||Surgical stapler|
|US8808310||Feb 14, 2007||Aug 19, 2014||Integrated Vascular Systems, Inc.||Resettable clip applier and reset tools|
|US8820602||Nov 19, 2010||Sep 2, 2014||Abbott Laboratories||Modular clip applier|
|US8821534||Dec 6, 2010||Sep 2, 2014||Integrated Vascular Systems, Inc.||Clip applier having improved hemostasis and methods of use|
|US8858594||Dec 18, 2009||Oct 14, 2014||Abbott Laboratories||Curved closure device|
|US8882786||Feb 17, 2004||Nov 11, 2014||Lawrence Livermore National Security, Llc.||System for closure of a physical anomaly|
|US8893947||Dec 17, 2007||Nov 25, 2014||Abbott Laboratories||Clip applier and methods of use|
|US8905937||Feb 26, 2009||Dec 9, 2014||Integrated Vascular Systems, Inc.||Methods and apparatus for locating a surface of a body lumen|
|US8915931||Feb 14, 2011||Dec 23, 2014||Ethicon Endo-Surgery, Inc.||Surgical clip and applier device and method of use|
|US8920442||Aug 23, 2006||Dec 30, 2014||Abbott Vascular Inc.||Vascular opening edge eversion methods and apparatuses|
|US8926633||Jun 19, 2006||Jan 6, 2015||Abbott Laboratories||Apparatus and method for delivering a closure element|
|US8926656||Jan 10, 2011||Jan 6, 2015||Integated Vascular Systems, Inc.||Clip applier and methods of use|
|US8956388||Apr 21, 2008||Feb 17, 2015||Integrated Vascular Systems, Inc.||Integrated vascular device with puncture site closure component and sealant|
|US9050068||May 20, 2013||Jun 9, 2015||Abbott Laboratories||Clip applier and methods of use|
|US9050087||May 14, 2008||Jun 9, 2015||Integrated Vascular Systems, Inc.||Integrated vascular device with puncture site closure component and sealant and methods of use|
|US9060769||May 1, 2008||Jun 23, 2015||Abbott Vascular Inc.||Surgical stapler|
|US9089311||Jan 8, 2010||Jul 28, 2015||Abbott Vascular Inc.||Vessel closure devices and methods|
|US9089674||Sep 15, 2006||Jul 28, 2015||Integrated Vascular Systems, Inc.||Apparatus and methods for positioning a vascular sheath|
|US9149276||Mar 21, 2011||Oct 6, 2015||Abbott Cardiovascular Systems, Inc.||Clip and deployment apparatus for tissue closure|
|US9173644||Jan 8, 2010||Nov 3, 2015||Abbott Vascular Inc.||Closure devices, systems, and methods|
|US9173656||Sep 14, 2012||Nov 3, 2015||Boston Scientific Scimed, Inc.||Methods and devices for folding and securing tissue|
|US9241696||Oct 29, 2009||Jan 26, 2016||Abbott Vascular Inc.||Closure device|
|US9271707||Mar 8, 2013||Mar 1, 2016||Integrated Vascular Systems, Inc.||Clip applier and methods of use|
|US9282965||May 16, 2008||Mar 15, 2016||Abbott Laboratories||Apparatus and methods for engaging tissue|
|US9295469||Jun 3, 2013||Mar 29, 2016||Abbott Vascular Inc.||Blood vessel closure clip and delivery device|
|US9314230||Aug 22, 2014||Apr 19, 2016||Abbott Vascular Inc.||Closure device with rapidly eroding anchor|
|US9320522||Aug 31, 2011||Apr 26, 2016||Integrated Vascular Systems, Inc.||Closure device and methods for making and using them|
|US9332976||Nov 30, 2011||May 10, 2016||Abbott Cardiovascular Systems, Inc.||Tissue closure device|
|US9364209||Dec 21, 2012||Jun 14, 2016||Abbott Cardiovascular Systems, Inc.||Articulating suturing device|
|US9398914||Sep 3, 2013||Jul 26, 2016||Integrated Vascular Systems, Inc.||Methods of use of a clip applier|
|US9402625||May 2, 2008||Aug 2, 2016||Abbott Vascular Inc.||Surgical stapler|
|US9414820||Jan 8, 2010||Aug 16, 2016||Abbott Vascular Inc.||Closure devices, systems, and methods|
|US9414824||Jul 3, 2014||Aug 16, 2016||Abbott Vascular Inc.||Closure devices, systems, and methods|
|US20020082621 *||Sep 21, 2001||Jun 27, 2002||Schurr Marc O.||Methods and devices for folding and securing tissue|
|US20020193808 *||Feb 21, 2002||Dec 19, 2002||Belef W. Martin||Apparatus and methods for delivering a closure device|
|US20030229368 *||Apr 22, 2003||Dec 11, 2003||Viola Frank J.||Endoscopic surgical clip|
|US20040097927 *||Feb 13, 2002||May 20, 2004||Yeung Jeffrey E.||Intervertebral disc repair|
|US20040249414 *||Dec 11, 2003||Dec 9, 2004||Christian Kissel||Medical clip and apparatus for the application of such a clip|
|US20060224170 *||Mar 30, 2006||Oct 5, 2006||Michael Duff||Surgical marker clip and method for cholangiography|
|US20060277725 *||Feb 18, 2004||Dec 14, 2006||Peter Weingartner||Clip for clipping sheets together|
|US20070118163 *||Nov 23, 2005||May 24, 2007||Ethicon Endo-Surgery, Inc.||Surgical clip and applier device and method of use|
|US20080132915 *||Jan 28, 2008||Jun 5, 2008||Buckman Robert F||Method and apparatus for vascular and visceral clipping|
|US20100179569 *||Jan 9, 2009||Jul 15, 2010||Salky Barry A||Laparoscopic Anastomosis Tools And Technique|
|US20100268022 *||Apr 5, 2006||Oct 21, 2010||Thompson Christopher C||Endoscopic gastric bypass defect repair|
|US20110077669 *||Mar 31, 2011||Salky Barry A||Laparoscopic Anastomosis Tools And Technique|
|US20110112558 *||Oct 4, 2010||May 12, 2011||OC2, LLC, a Massachusetts limited liability company||Tissue fixation system with single component anchor|
|US20110125171 *||May 26, 2011||Tyco Healthcare Group Lp||Endoscopic surgical clip|
|US20110137324 *||Jun 9, 2011||Ethicon Endo-Surgery, Inc.||Surgical clip and applier device and method of use|
|US20150088173 *||Mar 15, 2013||Mar 26, 2015||Arnoldo Guzman Sanchez||Compressive system for reducing edge bleeding in classical hysterotomy in cases of placenta praevia|
|USD611144||Mar 2, 2010||Abbott Laboratories||Apparatus for delivering a closure element|
|DE3008122A1 *||Mar 3, 1980||Sep 17, 1981||Zeppelin Dieter Von||Gefaess-klemme|
|DE3019116A1 *||May 20, 1980||Dec 3, 1981||Aesculap Werke Ag||Tissue ligature clamp - has convex-faced jaws of radius large enough to avoid tissue damage|
|DE3335985A1 *||Oct 4, 1983||May 2, 1985||Aesculap Werke Ag||Magazin zur aufnahme von c-foermigen scalpclips|
|DE3335986C1 *||Oct 4, 1983||Apr 4, 1985||Aesculap Werke Ag||Application device for C-shaped scalp clips|
|DE3443367A1 *||Nov 28, 1984||Jun 13, 1985||Kirsch Wolff Mayer||Chirurgischer mikroklip|
|DE19737976A1 *||Aug 30, 1997||Mar 18, 1999||Aesculap Ag & Co Kg||Surgical ligature clamp, especially useful as scalp clamp|
|DE19737976C2 *||Aug 30, 1997||Aug 14, 2003||Aesculap Ag & Co Kg||Chirurgische Ligaturklemme|
|EP0469524A1 *||Jul 29, 1991||Feb 5, 1992||JOHNSON & JOHNSON PROFESSIONAL, INC.||Surgical clip and surgical clip applier with reciprocating sleeve and dual rachet mechanism|
|EP0490411A1 *||Dec 13, 1991||Jun 17, 1992||United States Surgical Corporation||Latchless surgical clip|
|WO1988001486A1 *||Aug 19, 1987||Mar 10, 1988||Tucker Wilson H||Clip applicator and spreadable clips for use therein|
|U.S. Classification||606/158, 24/562, 24/DIG.220|
|Cooperative Classification||A61B17/1227, Y10S24/22|