|Publication number||US3605123 A|
|Publication date||Sep 20, 1971|
|Filing date||Apr 29, 1969|
|Priority date||Apr 29, 1969|
|Publication number||US 3605123 A, US 3605123A, US-A-3605123, US3605123 A, US3605123A|
|Original Assignee||Melpar Inc|
|Export Citation||BiBTeX, EndNote, RefMan|
|Referenced by (305), Classifications (14), Legal Events (4) |
|External Links: USPTO, USPTO Assignment, Espacenet|
US 3605123 A
Sept. 20, 1971 H BONE IMPLANT Filed April 29,
G I I Inventor HENRY HAHN A rfornevs United States Patent 3,605,123 BONE IMPLANT Henry Hahn, Fairfax, Va., assignor to Melpar, Inc., Falls Church, Va. Filed Apr. 29, 1969, Ser. No. 820,184 Int. Cl. A61f 1/22 US. Cl. 3-1 31 Claims ABSTRACT OF THE DISCLOSURE A permanent implant for bone tissue which has a dense cast or wrought base portion of high strength metal, and a porous metal layer overlying and bonded to the base portion. The porous layer is thin in comparison with the thickness of the base portion and is preferably plasma flame coated on the base portion. The shape of the base portion depends upon the specific requirements of the bone tissue it is to replace or repair. The porous layer may cover only that part of the surface of the base portion which is to be in contact with the bone tissue after implantation, and permits the growth of bone tissue into the pores.
BACKGROUND OF THE INVENTION The present invention relates generally to prosthetic parts, and is particularly concerned with improvements in prosthetic devices for use as high strength artificial bone implants adapted to promote a strong union with the bone matter into which such devices are implanted.
Devices in the form of plates, nails, pins, screws, and specially formed parts are commonly implanted into the skeletal structure of humans as artificial prosthetic means for permanent replacement of missing structural parts, or as permanent anchoring devices for maintaining a fixed relationship between the portions of a fractured bone. Clearly, in those situations where permanency is necessary or desirable, the implanted part should remain permanently adhered to the contacting bone surface. This requirement has been a source of some difliculty in the past, where prosthetic parts composed of high strength materials such as titanium, stainless steel, tantalum, or Vitallium (an alloy of cobalt, chromium, and molybdenum) have generally been found incapable of forming a strong union with the natural bone structure into which the implantation is made. Highly magnified photographs of sections taken through bone and implant where failure has occurred have revealed What appears .to be an absence of coalescence between the artificial and natural parts, and in fact an actual separation between the implant surface and the bone matter adjacent thereto is often apparent.
Several techniques have been proposed in an effort to overcome this difliculty. For example, it has been suggested, in US. Pat. No. 2,537,070, that a bone reinforcing member in the form of a perforated stainless steel tube be used as a permanent artificial member to assure union between portions of a fractured bone. According to that disclosure, the tube is inserted into a hole drilled in the bone through the fracture line, and is then filled with pulverized bone matter. The bone matter is packed by tamping with a ram to force it through the apertures in the tube wall and against the bones to be mended. The purpose is said to be subsequent solidification of the bone matter and union with the bone.
Another technique, advanced in US. Pat. No. 3,228,- 393, involves providing a portion of the prosthesis With fenestr-ae. Bone grafts pass through the fenestrae, and cancellous bone is packed into remaining recesses and grooves in the fenestrae to eventually unite with the cortical bone of the grafts.
There is no evidence that either of these techniques has proven successful. Furthermore, they require lengthy and relatively difficult procedures in the midst of the implant operation, dealing with introduction and packing of foreign bone matter into the patients bone structure. There is also the question of compatibility of the added bone matter with the existing bone.
Still another technique is described in US. Pat. No. 3,314,420, in which the implant is formed from a porous ceramic material filled with a synthetic organic plastic resin that adheres to the walls of the pores. The implant accepts growth of bone tissue against its surface to incorporate the artificial part into the skeletal structure of the patient. While this constitutes a generally easier and more efiicient technique of implantation and skeletal repair, it suffers from the use of a structurally weak implant material.
SUMMARY OF THE INVENTION The principal object of the present invention is to provide a prosthesis of high structural strength, with a capability of promoting substantially complete integration with the bone structure in which it is implanted.
I achieve that object by first providing a dense metal structure, preferably fabricated from wrought or cast metal, of appropriate shape for the part it is to replace or the function it is to serve, and capable of resisting the stresses to which it will be subjected during the normal activity of the person or animal into whose skeletal structure it is to be implanted. It is essential that the material of which this dense structure is composed have high strength; but, beyond that, it must also be easily formed in a desired shape, and it must be non-toxic to its host. Metals such as titanium, tantalum, stainless steel, and Vitallium have demonstrated these desirable properties over many years of use as prosthetic parts, but, as observed above, each has also demonstrated a failure to provide a strong bond with the bone structure into which it is implanted. As an important aspect of my invention, I provide on the surface of a dense structure composed of one of those metals, or of a metal of similar properties, and having the desired shape, a relatively thin highly porous layer that is effective in promoting the growth of bone tissue into the pores to produce a union between bone and artificial part. This poses a great number of problems, however, such as providing a strong bond between the =base metal and the overlying porous layer, while assuring the provision of an extremely thin layer; ensuring compatibility of the base metal and the ovrrlying material; elimination of any possibility of toxicity of the overlyng material to the system of the host into whom the artificial part is implanted; prevention of electrolytic elfect between material of which the overlying layer is composed and the base metal; and maintenance of at least similar coefiicients of thermal expansion between base metal and overlying layer to assure the continuance of a strong bond therebetween, to name a few of the problems.
Preferably, I coat the dense base metal with a thin porous film of the same metal to provide the desired chemical, electrochemical, and thermal compatibility and to overcome most of the problems noted above. The initial high strength bond between coating and base is preferably achieved by a flame spray process such as the plasma flame process. The result of this process is a densely adherent layer of the same metal as the base metal on the surface of the base metal, with no porosity or practically no porosity at the interface between coating and base metal and with gradually increasing porosity, including pore size and pore density, from the interface to the surface of the coating.
While I prefer to use the plasma flame process, I do not desire to limit my invention to such a process. For example, it is quite conceivable that a thin porous region can be provided at the surface of a dense wrought or cast metal prosthesis by a conventional chemical milling process, that is to say, without an actual application of a coating to the surface. At present, however, it appears questionable that suitable pore openings such as those obtained by plasma flame spray coating can be obtained by chemical milling.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a side view, partly in section, of a prosthetic part according to my invention;
FIG. 2 is a rendering of an actual photograph of a section, magnified 100 times, taken through the bone of an animal into which a prosthetic pin structurally similar to the member of FIG. 1 has been implanted several months earlier, and showing a portion of the pin, the coating thereon, and the bone;
FIG. 3 is a rendering of an actual photograph of a section like that of FIG. 2, but magnified 500 times, and showing only bone and pin coating; and
FIG. 4 is an exaggerated side view of the exterior of a pin with porous coating, similar to the pin used as the implant of FIGS. 2 and 3.
DESCRIPTION OF THE PREFERRED EMBODIMENT Referring to FIG. 1, a typical prosthesis includes a long shaft or nail 11 and a ball 12 integral with the shaft. The prosthesis may be composed of a metal conventionally used for that purpose, such as titanium, stainless steel, tantalum, or Vitallium. Purely for the sake of example, reference will hereinafter be made to the use of titanium as the base metal. Ball 12 is to be smooth and to constitute with the pelvic socket a hip joint normally formed by a thigh bone and the pelvis. The lower portion of shaft or nail 11, that is, the end opposite ball 12, however, is to be anchored within the remaining portion of the thigh bone (femur) of the human or animal patient. To that end, the normally smooth surface of the dense titanium member 10 is coated, in the region 11 at which a strong bond is to be formed with the bone, with a thin porous layer 13 of titanium.
For the purpose of clarity, layer 13 is exaggerated in thickness relative to the thickness of the prosthetic part. In practice, the porous surface layer will be extremely thin in comparison to the thickness of the base metal on which it is coated. As an example, the coating thickness may be up to approximately 0.1 inch, but the optimum thickness (or thinness, depending on point of view), and the preferred thickness, is from about 0.015 to about 0.030 inch.
At the interface between layer 13 and the surface of I the base metal (shaft 11) the layer is almost completely dense, i.e., is for practical purposes free of pores or interstices. However, in approaching the exterior surface of layer 13, the layer becomes progressively more porous, with some pores cut off from the surrounding environment by metal portions, others exposed at the exterior surface, and still others connected by interior passageways. In practice, the pores will range from about 30 microns to about 200 wide at the opening, although the range of widths from about 40 to about 70,11. appears to be optimum.
In producing a prosthetic part such as 10, the base metal is first formed, for example as a cast or wrought structure, in the shape desired for the specific application. As in the application exemplified by FIG. 1, it may be desired that the prosthetic part or implant have a smooth surface in one or more portions (as at 12), and that it promote adherence with the bone tissue in one or more of its other portions. In accordance with the present invention, the surface areas to be coated with a porous 4 layer may be selected commensurate with these criteria, as by masking specified locales of the base metal surface that are to be free of any coating.
Preferably, the coating or layer 13 is applied to the base metal by a plasma spraying process, as is generally described in Nuclear Applications of Nonfisssionable Ceramics, Boltax and Handwerk ct. (American Nuclear Society, 1966), in the section authored by myself and Joseph Pentacost, at pages 359 et seq., and elsewhere in Flame Spray Handbook, vol. III, Plasma Flame Process (Metco Ltd., 1965), for example. Briefly, in the plasma spray process, a mixture of nitrogen and hydrogen gases is fed under pressure of about 200 pounds or more toward the space between a central electrode and a surrounding outer electrode between which an arc is created by virtue of a voltage across the electrodes and a high current that flows upon breakdown of the central air gap. The combination of the electrode arc and the high pressure gas flow create a rapidly moving high energy flux at a temperature generally ranging from about 30,000 F. at its center to 20,000 F. at its periphery. It is into this high energy, high temperature flux that the material to be deposited (or more aptly, a material from which the material to be deposited is to be derived in a reaction with the heat of the flame) is fed. In the case of titanium as a base metal, titanium hydride powder carried by an inert carrier gas such as argon is delivered under pressure into the electrode area at which the flux is created, resulting in a plasma coating of substantially pure titanium metal on that portion of the titanium base metal of the prosthetic part which is unmasked and held in a region adjacent the high temperature fiux. The coating thickness specified above and the size of the pore openings may be readily controlled by timing the delivery and amount of titanium hydride to the electrode region and the manner of exposure of the part to be coated to the plasma flux. Again, I do not restrict my invention to use of the plasma spray process, although that is preferred, and I again emphasize that a porous surface region may be provided on the base metal Without use of any coating process, but instead by employing a chemical milling process. In the latter situation, undercut pores (i.e., pores having relatively small openings in the size range mentioned above, but having wider interiors) are obtained in the immediate vicinity of the surface of the base metal.
The improved surface adherence of bone to plasma coated titanium pins (although plasma coated stainless steel, tantalum, or Vitallium pins are similarly effective) was demonstrated in one experiment by implanting a total of six pins in the right and left femurs of a sheep. Of the three pins in each femur, one was a solid titanium. pin used as a control specimen, and the others were coarse and fine plasma coated titanium pins, respectively, differing only in the general size of the pore openings at either end of the aforementioned 30 to 200 range, and each of the latter two pins having a coating thickness of approximately 0.035 inch. Each pin, including the control specimen, was provided with a head left exposed at the surface of the bone to permit subsequent attempts at rotation and/ or removal with a torque wrench. The character and general appearance of the coating 13 on the plasma coated pins is quite vividly presented in FIG. 4, a rendering of an actual photograph of such a coated pin, magnified approximately six times. Some three months after the implantation of the six pins, the sheep was returned to the laboratory to permit tests of the extent of union of pins and bone tissue, and to attempt rotation of the pins in each femur. Prior to torque testing, suflicient bone material was removed from the underside of the head of each pin to ensure an absence of any interference between the bone and the underhead area of the ins. It was found that in both the right and the left femurs the solid titanium pin (control specimen) was easily rotated and removed from the bone, at a torque of 406,600 dynes per square centimeter on the control pin in the right femur, and of 1,617,800 dynes/cm. on the control pin in the left femur. On the other hand, each of the coated pins failed as a result of plastic deformation or shearing of the head during the torque tests. Failure occurred at the following torques, each value of which was therefore lower than the value of torque that would have been required to rotate the respective pin: for the coarse plasma coated pin 21,987,600 dynes/cm. in the right femur, and 16, 61 1,100 dynes/cm. in the left femur; and for the fine plasma coated pin, 22,153,600 dynes/cm. in the right femur, and 22,402,500 dynm/cm. in the left femur.
The easy removal of the solid titanium control pins was followed by observation of the holes in the bones from which those pins had been removed, and each of these holes was found to be clean, i.e., to possess clean smooth walls, free of disruption. However, only one of the plasma coated pins could be removed, even under attempts at hammering out, and that was the fine plasma coated pin in the right femur. Removal of the latter pin resulted from shearing of the interface between the plasma coating and the base metal. Renderings of actual photographs of sections through bone and coated pin, magnified 100 and 500 times, are presented in FIGS. 2 and 3 respectively, and clearly demonstrate the manner in which the bone tissue has grown against and into the porous surface of the coating in each instance. In FIG. 2, the bone is designated by reference numeral 20, the pin by reference numeral 21, and the plasma coating by reference numeral 22. If complete adherence were not present, a void or gap would have remained between bone tissue 20 and coating 22 in the region 25 of FIG. 2. Similar bonding or union is indicated in FIG. 3 with the bone designated 30 and the plasma coating designated 32. Here again, it is readily observable that the bone tissue completely follows the rough contour of the coating surface. The dark areas at the interface between bone and coating in FIGS. 2 and 3, and between coating and base in FIG. 2, have been eXaggerated slightly for the purpose of clarity. Actually, the photographs indicate a thorough bond between the materials at the respective interfaces.
A histological study of the coated pins in the bone revealed growth of bone tissue into the pores at the surface of the coating. Thus, the plasma coated prosthetic part was firmly anchored in place.
The present invention is applicable to prosthetic devices of all types and purposes, including dental applications such as the anchoring of one or more permanent artificial teeth in the jawbone. Whatever the application in which the prosthesis is used, it has been found that those parts produced according to the present invention possess impact strengths ranging up to 80 times that of prior art prosthetic parts. Reported failures caused by fatigue and impact in completely porous ceramic implants were completely absent in tests on dense metal implants having only a thin porous surface region.
1. A prosthetic part for use on a bone implant, comprising a strong metal base, said metal base being substantially non-toxic to the biological system of the host into whose bone structure said prosthetic part is to be implanted, and a highly porous metallic region at a surface of said base, said porous region being extremely thin relative to the thickness of said base and extending over substantially that portion of the surface of said base which is to 'be in contact with the bone structure after implantation.
2. The prosthetic part according to claim 1 wherein the metal of which said base is composed is selected from the group consisting of titanium, stainless steel, tantalum, and Vitallium.
3. The prosthetic part according to claim 1 wherein said porous region is a layer bonded to the surface of said base, said layer being relatively dense at the inter- 6 face with the base metal and of progressively greater porosity toward the exterior surface of said layer.
4. The prosthetic part according to claim 3 wherein said layer is composed of a material having a coefficient of thermal expansion substantially equivalent to that of said base metal.
-5. The prosthetic part according to claim 4 wherein said layer is a plasma coating on the surface of said base.
6. The prosthetic part according to claim 5 wherein said layer has a thickness less than 0.1 inch.
7. The prosthetic part according to claim 6 wherein the pore openings at the exterior surface of said layer have widths in the range from about 30 microns to about 200 microns.
8. The prosthetic part according to claim 7 wherein said base metal is titanium and said porous layer is titanium.
9. The prosthetic part according to claim 3 wherein said porous layer is composed of at least substantially the same metal as said base metal.
10. A member adapted to promote adherence of bone tissue thereto, said member comprising a highly dense base portion of metal, and a region of high porosity metal coating on the surface of said base portion, said region being thin relative to the thickness of said base portion and arranged for promoting the growth of bone tissue to said member when said member is implanted with said region adjacent living bone tissue.
11. The invention according to claim 10 wherein said region is a layer of material overlying the surface of said base portion and bonded thereto.
12. The invention according to claim 11 wherein said layer extends over only a part of the surface of said base portion.
13. The invention according to claim 11 wherein the material of which said layer is composed is substantially the same metal as the metal of which said base portion is composed.
14. For use as a permanent home implant, a structural member including a base composed of metal substantially free of interstices, said member possessing a shape commensurate with a bone repair function; and a porous metallic region, thin relative to the thickness of said base located on the surface of said base.
15. The invention according to claim 14 wherein said porous region covers only a part of the surface of said base conforming substantially to that portion of the member to be in contact with bone tissue.
16. The invention according to claim 14 wherein said porous region is a metal layer overlying and bonded to the surface of said base.
17. The invention according to claim 16 wherein both said base and said layer are composed of titanium.
18. An implant for bone tissue including a base portion of high strength metal and a porous metal layer overlying and bonded to said base portion.
19. The combination according to claim 18, wherein said porous metal layer is plasma flame coated on said base portion.
20. The combination according to claim 19, wherein said high strength metal and said porous metal layer are essentially the same metals.
21. The combination according to claim 18, wherein said high strength metal and said porous metal layer are of essentially the same metal.
22. The combination according to claim 18, wherein said high strenght metal is incapable of forming a strong union with said bone tissue absent said layer.
23. The combination according to claim 19, wherein said high strength metal is incapable of forming a strong union with said bone tissue absent said layer.
24. The combination according to claim 19, wherein said metal is selected from the group consisting of titanium, stainless steel, tantalum, and Vitallium.
25. A bone implant, including a base portion composed of high strength metal and a porous layer overlying said base portion, said metal and layer being non-toxic to said bone, and being chemically, electrochemically and thermally compatible with each other, said porous layer being of gradually increasing porosity in proceeding from the interface of said base portion layer to the outer surface of said layer and of negligible porosity at said interface.
26. The combination according to claim 25, wherein said porous layer is plasma flame coated metal.
27. The combination according to claim 25, wherein said porous layer is metallic.
28. The combination according to claim 25, wherein said porous layer has a thickness of between about .030" to .015".
29. A metallic bone implant having a porous metallic surface layer.
30. The combination according to claim 29, wherein said implant and said surface layer are chemically, electrochemically, and thermally compatible and non-toxic to said bone.
31. The combination according to claim 30, wherein said implant and said surface layer are of essentially the same metals.
References Cited UNITED STATES PATENTS 448,745 3/1891 Wright 32--l0 2,688,139 9/1954 Jardon 313 3,314,420 4/1967 Smith et a1. 12892 FOREIGN PATENTS 1,122,634 5/1956 France 12892 LAWRENCE W. TRAPP, Primary Examiner US. Cl. X.R. 12892C
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3700380 *||Oct 1, 1970||Oct 24, 1972||Tecna Corp||Surface or lining compatible with blood or other tissue|
|US3707967 *||Oct 1, 1970||Jan 2, 1973||Tecna Corp||Steady flow regenerative peritoneal dialysis system and method|
|US3808606 *||Mar 19, 1973||May 7, 1974||R Tronzo||Bone implant with porous exterior surface|
|US3840904 *||Apr 30, 1973||Oct 15, 1974||R Tronzo||Acetabular cup prosthesis|
|US3843974 *||Jan 5, 1972||Oct 29, 1974||Us Health Education & Welfare||Intimal lining and pump with vertically drafted webs|
|US3843975 *||Apr 9, 1973||Oct 29, 1974||Tronzo R||Prosthesis for femoral shaft|
|US3848273 *||Jan 29, 1973||Nov 19, 1974||Sulzer Ag||Shank for bone implants|
|US3852045 *||Aug 14, 1972||Dec 3, 1974||Battelle Memorial Institute||Void metal composite material and method|
|US3855638 *||May 16, 1973||Dec 24, 1974||Ontario Research Foundation||Surgical prosthetic device with porous metal coating|
|US3905777 *||Jan 28, 1974||Sep 16, 1975||Louyot Comptoir Lyon Alemand||Composite and porous metallic members which can be used for bone prosthesis|
|US3906549 *||Jul 17, 1974||Sep 23, 1975||Bucalo Louis||Implanting structure and method|
|US3916905 *||Nov 9, 1973||Nov 4, 1975||William E Kuhn||Method and means for the repair of severed peripheral nerves|
|US3918100 *||May 13, 1974||Nov 11, 1975||Us Navy||Sputtering of bone on prostheses|
|US3919773 *||Dec 20, 1973||Nov 18, 1975||Sybron Corp||Direct moldable implant material|
|US3971134 *||Jan 31, 1975||Jul 27, 1976||General Atomic Company||Carbon dental implant with artificial periodontal ligament|
|US3976547 *||Nov 19, 1974||Aug 24, 1976||Merck & Co., Inc.||Cell and vaccine production|
|US4026304 *||Nov 6, 1974||May 31, 1977||Hydro Med Sciences Inc.||Bone generating method and device|
|US4047523 *||Apr 26, 1976||Sep 13, 1977||Downs Surgical Limited||Surgical sacral anchor implant|
|US4073999 *||May 9, 1975||Feb 14, 1978||Minnesota Mining And Manufacturing Company||Porous ceramic or metallic coatings and articles|
|US4074366 *||Jul 22, 1976||Feb 21, 1978||American Cyanamid Company||Poly(N-acetyl-D-glucosamine) products|
|US4074713 *||Jul 22, 1976||Feb 21, 1978||American Cyanamid Company||Poly(N-acetyl-D-glucosamine) products|
|US4145764 *||Jul 21, 1976||Mar 27, 1979||Matsumoto Dental College||Endosseous implants|
|US4158684 *||Dec 13, 1976||Jun 19, 1979||The United States Of America As Represented By The Secretary Of The Navy||Method of making ceramic prosthetic implant suitable for a knee joint|
|US4179485 *||Jan 13, 1978||Dec 18, 1979||Ceraver||Bone prosthesis and method of manufacture thereof|
|US4195409 *||Feb 13, 1978||Apr 1, 1980||Child Laboratories Inc.||Dental implant|
|US4198713 *||Mar 29, 1979||Apr 22, 1980||Swanson Alfred B||Protective member for implantable prosthesis and method of protecting the prosthesis|
|US4237559 *||May 11, 1979||Dec 9, 1980||General Electric Company||Bone implant embodying a composite high and low density fired ceramic construction|
|US4252525 *||Dec 17, 1979||Feb 24, 1981||Child Frank W||Dental implant|
|US4263681 *||May 30, 1978||Apr 28, 1981||Johnson, Matthey & Co., Limited||Coated metallic bone joint prosthesis resistant to synovial fluid corrosion|
|US4278630 *||Jan 2, 1979||Jul 14, 1981||Hans Scheicher||Method for the preparation of implants, and implants|
|US4292694 *||Jun 25, 1980||Oct 6, 1981||Lord Corporation||Prosthesis anchoring means|
|US4292695 *||Jun 25, 1980||Oct 6, 1981||Lord Corporation||Prosthesis stem|
|US4314381 *||Jun 25, 1980||Feb 9, 1982||Lord Corporation||Hip joint prosthesis|
|US4330891 *||Feb 28, 1980||May 25, 1982||Branemark Per Ingvar||Element for implantation in body tissue, particularly bone tissue|
|US4446857 *||Sep 4, 1979||May 8, 1984||Schwarzkopf Development Corporation||Medullary nail and process for the production thereof|
|US4479271 *||Oct 26, 1981||Oct 30, 1984||Zimmer, Inc.||Prosthetic device adapted to promote bone/tissue ingrowth|
|US4488319 *||Oct 26, 1981||Dec 18, 1984||Clemson University||Method of two-stage implantation of a joint prosthesis and prosthetic product|
|US4542539 *||Jan 31, 1984||Sep 24, 1985||Artech Corp.||Surgical implant having a graded porous coating|
|US4550448 *||Feb 18, 1985||Nov 5, 1985||Pfizer Hospital Products Group, Inc.||Bone prosthesis with porous coating|
|US4566138 *||Apr 24, 1985||Jan 28, 1986||Zimmer, Inc.||Prosthetic device with spacers|
|US4608052 *||Apr 25, 1984||Aug 26, 1986||Minnesota Mining And Manufacturing Company||Implant with attachment surface|
|US4612160 *||Apr 2, 1984||Sep 16, 1986||Dynamet, Inc.||Porous metal coating process and mold therefor|
|US4626209 *||Apr 17, 1984||Dec 2, 1986||Unitek Corporation||Orthodontic bracket with metallic coated bonding base|
|US4673409 *||Mar 27, 1986||Jun 16, 1987||Minnesota Mining And Manufacturing Company||Implant with attachment surface|
|US4704126 *||Apr 15, 1985||Nov 3, 1987||Richards Medical Company||Chemical polishing process for titanium and titanium alloy surgical implants|
|US4715860 *||Aug 23, 1985||Dec 29, 1987||The Regents Of The University Of California||Porous acetabular hip resurfacing|
|US4722870 *||Jan 22, 1985||Feb 2, 1988||Interpore International||Metal-ceramic composite material useful for implant devices|
|US4731088 *||Jun 2, 1986||Mar 15, 1988||Boehringer Mannheim Corp||Enclosure member for prosthetic joint|
|US4813963 *||Aug 24, 1987||Mar 21, 1989||Zimmer, Inc.||Femoral component for a hip prosthesis|
|US4829152 *||Nov 16, 1987||May 9, 1989||Rostoker, Inc.||Method of resistance welding a porous body to a substrate|
|US4834756 *||Oct 15, 1985||May 30, 1989||Pfizer Hospital Products Group, Inc.||Bone prosthesis with porous coating|
|US4846839 *||Apr 8, 1988||Jul 11, 1989||Joint Medical Products Corporation||Apparatus for affixing a prosthesis to bone|
|US4851008 *||Feb 1, 1988||Jul 25, 1989||Orthomet, Inc.||Bone implant prosthesis with substantially stress-free outer surface|
|US4865603 *||Feb 4, 1988||Sep 12, 1989||Joint Medical Products Corporation||Metallic prosthetic devices having micro-textured outer surfaces|
|US4883488 *||Jun 13, 1988||Nov 28, 1989||Harrington Arthritis Research Center||Tibial component for a knee prosthesis|
|US4938769 *||May 31, 1989||Jul 3, 1990||Shaw James A||Modular tibial prosthesis|
|US4944742 *||Jun 5, 1989||Jul 31, 1990||Johnson & Johnson Orthopaedics, Inc.||Bone pin|
|US4997445 *||Dec 8, 1989||Mar 5, 1991||Zimmer, Inc.||Metal-backed prosthetic implant with enhanced bonding of polyethylene portion to metal base|
|US5004476 *||Oct 31, 1989||Apr 2, 1991||Tulane University||Porous coated total hip replacement system|
|US5007931 *||May 4, 1990||Apr 16, 1991||Boehringer Mannheim Corporation||Porous coated prosthesis|
|US5013324 *||Nov 28, 1988||May 7, 1991||Zimmer, Inc.||Prosthetic implant with wrapped porous surface|
|US5018285 *||Jan 16, 1990||May 28, 1991||Zimmer, Inc.||Method of constructing prosthetic implant with wrapped porous surface|
|US5035713 *||Feb 12, 1990||Jul 30, 1991||Orthopaedic Research Institute, Inc.||Surgical implants incorporating re-entrant material|
|US5080671 *||Jul 31, 1989||Jan 14, 1992||Uri Oron||Method of treating a metal prosthetic device prior to surgical implantation to enhance bone growth relative thereto following implantation|
|US5080674 *||Sep 20, 1990||Jan 14, 1992||Zimmer, Inc.||Attachment mechanism for securing an additional portion to an implant|
|US5098434 *||Nov 28, 1990||Mar 24, 1992||Boehringer Mannheim Corporation||Porous coated bone screw|
|US5100323 *||Sep 5, 1990||Mar 31, 1992||Impla-Med Incorporated||Dental implant|
|US5108432 *||Jun 24, 1990||Apr 28, 1992||Pfizer Hospital Products Group, Inc.||Porous fixation surface|
|US5108435 *||Dec 19, 1990||Apr 28, 1992||Pfizer Hospital Products Group, Inc.||Cast bone ingrowth surface|
|US5147403 *||Mar 15, 1989||Sep 15, 1992||United States Gypsum Company||Prosthesis implantation method|
|US5192324 *||Jan 2, 1990||Mar 9, 1993||Howmedica Inc.||Bone prosthesis with porous coating|
|US5198308 *||Dec 21, 1990||Mar 30, 1993||Zimmer, Inc.||Titanium porous surface bonded to a cobalt-based alloy substrate in an orthopaedic implant device|
|US5217496 *||Sep 30, 1992||Jun 8, 1993||Ab Idea||Implant and method of making it|
|US5263986 *||Jan 22, 1993||Nov 23, 1993||Joint Medical Products Corporation||Sintered coatings for implantable prostheses|
|US5323954 *||Nov 30, 1992||Jun 28, 1994||Zimmer, Inc.||Method of bonding titanium to a cobalt-based alloy substrate in an orthophedic implant device|
|US5358533 *||Jan 21, 1993||Oct 25, 1994||Joint Medical Products Corporation||Sintered coatings for implantable prostheses|
|US5360452 *||Dec 6, 1993||Nov 1, 1994||Depuy Inc.||Enhanced fixation system for a prosthetic implant|
|US5370698 *||May 18, 1993||Dec 6, 1994||Clemson University||Isoelastic implants with improved anchorage means|
|US5373621 *||Jul 26, 1993||Dec 20, 1994||The Trustees Of The University Of Pennsylvania||Porous coated implants having improved fatigue behavior|
|US5387243 *||Nov 23, 1992||Feb 7, 1995||Zimmer, Inc.||Method for converting a cementable implant to a press fit implant|
|US5405389 *||Feb 18, 1993||Apr 11, 1995||Joint Medical Products Corporation||Sintered coatings for implantable prostheses|
|US5441537 *||Dec 4, 1992||Aug 15, 1995||Howmedica Inc.||Bone prosthesis with porous coating|
|US5480444 *||Jun 2, 1994||Jan 2, 1996||Incavo; Stephen J.||Hybrid tibial tray knee prosthesis|
|US5489306 *||Jan 3, 1995||Feb 6, 1996||Gorski; Jerrold M.||Graduated porosity implant for fibro-osseous integration|
|US5505984 *||Jan 21, 1993||Apr 9, 1996||England; Garry L.||Method for forming biocompatible components using an isostatic press|
|US5522817 *||Feb 24, 1994||Jun 4, 1996||United States Surgical Corporation||Absorbable surgical fastener with bone penetrating elements|
|US5540697 *||Oct 7, 1994||Jul 30, 1996||U.S. Medical Products, Inc.||Prosthetic socket installation apparatus and method|
|US5549697 *||Sep 22, 1994||Aug 27, 1996||Johnson & Johnson Professional, Inc.||Hip joint prostheses and methods for manufacturing the same|
|US5641323 *||Jan 16, 1996||Jun 24, 1997||Johnson & Johnson Professional, Inc.||Self-lubricating implantable articulation member|
|US5653765 *||Jan 3, 1995||Aug 5, 1997||Ortho Development Corporation||Modular prosthesis|
|US5662158 *||Jun 2, 1995||Sep 2, 1997||Johnson & Johnson Professional, Inc.||Self-lubricating implantable articulation member|
|US5672284 *||Mar 1, 1996||Sep 30, 1997||Zimmer, Inc.||Method of making orthopaedic implant by welding|
|US5674285 *||Dec 12, 1995||Oct 7, 1997||Medical Products Development, Inc.||Mammary implant having shell with unitary rough-textured outer layer|
|US5683471 *||Sep 12, 1995||Nov 4, 1997||Incavo; Stephen J.||Hybrid tibial tray knee prosthesis|
|US5716414 *||Feb 10, 1997||Feb 10, 1998||Johnson & Johnson Professional, Inc.||Ceramic/metallic articulation component and prothesis|
|US5725594 *||Feb 12, 1996||Mar 10, 1998||Ortho Development Corporation||Proximal conical stem|
|US5741253 *||Oct 29, 1992||Apr 21, 1998||Michelson; Gary Karlin||Method for inserting spinal implants|
|US5755810 *||Nov 13, 1996||May 26, 1998||Cunningham; Robert A.||Hip implant prosthesis|
|US5772661 *||Feb 27, 1995||Jun 30, 1998||Michelson; Gary Karlin||Methods and instrumentation for the surgical correction of human thoracic and lumbar spinal disease from the antero-lateral aspect of the spine|
|US5773789 *||May 23, 1996||Jun 30, 1998||Bristol-Myers Squibb Company||Method of making an orthopaedic implant having a porous metal pad|
|US5788916 *||Apr 30, 1996||Aug 4, 1998||Johnson & Johnson Professional, Inc.||Hip joint prostheses and methods for manufacturing the same|
|US5797909 *||Jun 7, 1995||Aug 25, 1998||Michelson; Gary Karlin||Apparatus for inserting spinal implants|
|US5807407 *||May 4, 1992||Sep 15, 1998||Biomet, Inc.||Medical implant device and method for making same|
|US5876454 *||Jun 28, 1996||Mar 2, 1999||Universite De Montreal||Modified implant with bioactive conjugates on its surface for improved integration|
|US5945153 *||Jul 29, 1997||Aug 31, 1999||Southwest Research Institute||Non-irritating antimicrobial coating for medical implants and a process for preparing same|
|US5973222 *||Jan 16, 1998||Oct 26, 1999||Bristol-Myers Squibb Co.||Orthopedic implant having a porous metal pad|
|US5984905 *||Mar 18, 1997||Nov 16, 1999||Southwest Research Institute||Non-irritating antimicrobial coating for medical implants and a process for preparing same|
|US6008432 *||Oct 1, 1997||Dec 28, 1999||Osteonics Corp.||Metallic texture coated prosthetic implants|
|US6049054 *||Aug 21, 1997||Apr 11, 2000||Bristol-Myers Squibb Company||Method of making an orthopaedic implant having a porous metal pad|
|US6096038 *||Jun 7, 1995||Aug 1, 2000||Michelson; Gary Karlin||Apparatus for inserting spinal implants|
|US6105235 *||Jun 1, 1995||Aug 22, 2000||Johnson & Johnson Professional, Inc.||Ceramic/metallic articulation component and prosthesis|
|US6120502 *||May 27, 1994||Sep 19, 2000||Michelson; Gary Karlin||Apparatus and method for the delivery of electrical current for interbody spinal arthrodesis|
|US6123705 *||Oct 1, 1996||Sep 26, 2000||Sdgi Holdings, Inc.||Interbody spinal fusion implants|
|US6127596 *||Jan 23, 1998||Oct 3, 2000||Sulzer Orthopedics Inc.||Implantable orthopedic prosthesis having tissue attachment surface and method of manufacture|
|US6149650 *||May 8, 1998||Nov 21, 2000||Michelson; Gary Karlin||Threaded spinal implant|
|US6210412||Jun 7, 1995||Apr 3, 2001||Gary Karlin Michelson||Method for inserting frusto-conical interbody spinal fusion implants|
|US6224595||Apr 20, 1998||May 1, 2001||Sofamor Danek Holdings, Inc.||Method for inserting a spinal implant|
|US6264656||May 8, 1998||Jul 24, 2001||Gary Karlin Michelson||Threaded spinal implant|
|US6270498||Jun 7, 1995||Aug 7, 2001||Gary Karlin Michelson||Apparatus for inserting spinal implants|
|US6332896||Nov 12, 1998||Dec 25, 2001||Ortho Development Corporation||Orthopaedic implant with proximal collar|
|US6361567||Nov 12, 1999||Mar 26, 2002||Southwest Research Institute||Non-irritating antimicrobial coating for medical implants and a process for preparing same|
|US6491723||Mar 1, 1999||Dec 10, 2002||Implant Innovations, Inc.||Implant surface preparation method|
|US6599322||Oct 12, 2001||Jul 29, 2003||Tecomet, Inc.||Method for producing undercut micro recesses in a surface, a surgical implant made thereby, and method for fixing an implant to bone|
|US6605089||Sep 23, 1999||Aug 12, 2003||Gary Karlin Michelson||Apparatus and method for the delivery of electrical current for interbody spinal arthrodesis|
|US6620332||Dec 12, 2001||Sep 16, 2003||Tecomet, Inc.||Method for making a mesh-and-plate surgical implant|
|US6652765||Feb 6, 2001||Nov 25, 2003||Implant Innovations, Inc.||Implant surface preparation|
|US6682567||Sep 19, 2001||Jan 27, 2004||Biomet, Inc.||Method and apparatus for providing a shell component incorporating a porous ingrowth material and liner|
|US6758849||Aug 18, 2000||Jul 6, 2004||Sdgi Holdings, Inc.||Interbody spinal fusion implants|
|US6770074||Nov 17, 2001||Aug 3, 2004||Gary Karlin Michelson||Apparatus for use in inserting spinal implants|
|US6875213||Feb 21, 2003||Apr 5, 2005||Sdgi Holdings, Inc.||Method of inserting spinal implants with the use of imaging|
|US6913624||Oct 9, 2001||Jul 5, 2005||Ortho Development Corporation||Orthopaedic implant with proximal collar|
|US6923810||Jun 7, 1995||Aug 2, 2005||Gary Karlin Michelson||Frusto-conical interbody spinal fusion implants|
|US6945448 *||Jun 6, 2003||Sep 20, 2005||Zimmer Technology, Inc.||Method for attaching a porous metal layer to a metal substrate|
|US6969474||Nov 5, 2003||Nov 29, 2005||Implant Innovations, Inc.||Implant surface preparation|
|US7018418||Jul 24, 2002||Mar 28, 2006||Tecomet, Inc.||Textured surface having undercut micro recesses in a surface|
|US7044972||Jul 30, 2003||May 16, 2006||Synthes Ag Chur||Bone implant, in particular, an inter-vertebral implant|
|US7169317||Jul 1, 2005||Jan 30, 2007||Implant Innovations, Inc.||Implant surface preparation|
|US7207991||Mar 18, 2002||Apr 24, 2007||Warsaw Orthopedic, Inc.||Method for the endoscopic correction of spinal disease|
|US7255698||Aug 11, 2003||Aug 14, 2007||Warsaw Orthopedic, Inc.||Apparatus and method for anterior spinal stabilization|
|US7264622||Oct 24, 2003||Sep 4, 2007||Warsaw Orthopedic, Inc.||System for radial bone displacement|
|US7291149||Oct 4, 1999||Nov 6, 2007||Warsaw Orthopedic, Inc.||Method for inserting interbody spinal fusion implants|
|US7323013||Sep 13, 2002||Jan 29, 2008||Encore Medical Asset Corporation||Differential porosity prosthetic hip system|
|US7326214||Aug 9, 2003||Feb 5, 2008||Warsaw Orthopedic, Inc.||Bone cutting device having a cutting edge with a non-extending center|
|US7399303||Aug 20, 2002||Jul 15, 2008||Warsaw Orthopedic, Inc.||Bone cutting device and method for use thereof|
|US7431722||Jun 6, 2000||Oct 7, 2008||Warsaw Orthopedic, Inc.||Apparatus including a guard member having a passage with a non-circular cross section for providing protected access to the spine|
|US7452359||Jun 7, 1995||Nov 18, 2008||Warsaw Orthopedic, Inc.||Apparatus for inserting spinal implants|
|US7455672||Jul 31, 2003||Nov 25, 2008||Gary Karlin Michelson||Method for the delivery of electrical current to promote bone growth between adjacent bone masses|
|US7491205||Jun 7, 1995||Feb 17, 2009||Warsaw Orthopedic, Inc.||Instrumentation for the surgical correction of human thoracic and lumbar spinal disease from the lateral aspect of the spine|
|US7507256||Dec 14, 2005||Mar 24, 2009||Depuy Products, Inc.||Modular implant system and method with diaphyseal implant|
|US7531518||May 11, 2005||May 12, 2009||Unigene Laboratories Inc.||Method for fostering bone formation and preservation|
|US7534254||Jun 7, 1995||May 19, 2009||Warsaw Orthopedic, Inc.||Threaded frusto-conical interbody spinal fusion implants|
|US7537664 *||Nov 7, 2003||May 26, 2009||Howmedica Osteonics Corp.||Laser-produced porous surface|
|US7547399||Jan 9, 2007||Jun 16, 2009||Biomet 3I, Llc||Implant surface preparation|
|US7550091||Feb 19, 2008||Jun 23, 2009||Biomet 3I, Llc||Implant surface preparation|
|US7569054||Nov 8, 2005||Aug 4, 2009||Warsaw Orthopedic, Inc.||Tubular member having a passage and opposed bone contacting extensions|
|US7597715||Feb 17, 2006||Oct 6, 2009||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US7635447||Feb 17, 2006||Dec 22, 2009||Biomet Manufacturing Corp.||Method and apparatus for forming porous metal implants|
|US7648700||Aug 16, 2007||Jan 19, 2010||Unigene Laboratories, Inc.||Method for fostering bone formation and preservation|
|US7648965||Nov 7, 2005||Jan 19, 2010||Unigene Laboratories Inc.||Method for fostering bone formation and preservation|
|US7686805||Jul 1, 2004||Mar 30, 2010||Warsaw Orthopedic, Inc.||Methods for distraction of a disc space|
|US7691148||Mar 19, 2005||Apr 6, 2010||Warsaw Orthopedic, Inc.||Frusto-conical spinal implant|
|US7699203||Nov 13, 2006||Apr 20, 2010||Warsaw Orthopedic, Inc.||Variable angle surgical staple inserter|
|US7713307 *||May 23, 2000||May 11, 2010||Nobel Biocare Ab (Publ.)||Layer arranged on implant for bone or tissue structure|
|US7722619||Apr 25, 2006||May 25, 2010||Warsaw Orthopedic, Inc.||Method of maintaining distraction of a spinal disc space|
|US7722735||Apr 6, 2007||May 25, 2010||C3 Materials Corp.||Microstructure applique and method for making same|
|US7776826||Mar 31, 2008||Aug 17, 2010||Unigene Laboratories, Inc.||Method for fostering bone formation and preservation|
|US7789914||Aug 26, 2004||Sep 7, 2010||Warsaw Orthopedic, Inc.||Implant having arcuate upper and lower bearing surfaces along a longitudinal axis|
|US7796791||Nov 7, 2003||Sep 14, 2010||Conformis, Inc.||Methods for determining meniscal size and shape and for devising treatment|
|US7799077||Oct 7, 2003||Sep 21, 2010||Conformis, Inc.||Minimally invasive joint implant with 3-dimensional geometry matching the articular surfaces|
|US7799085||Apr 2, 2004||Sep 21, 2010||Depuy Products, Inc.||Modular implant system with fully porous coated sleeve|
|US7828800||May 18, 2009||Nov 9, 2010||Warsaw Orthopedic, Inc.||Threaded frusto-conical interbody spinal fusion implants|
|US7850862||Feb 1, 2006||Dec 14, 2010||Tecomet Inc.||Textured surface having undercut micro recesses in a surface|
|US7854958 *||Mar 18, 2009||Dec 21, 2010||Advanced Cardiovascular Systems, Inc.||Method and apparatus for spray processing of porous medical devices|
|US7857987||Feb 13, 2008||Dec 28, 2010||Biomet 3I, Llc||Implant surface preparation|
|US7867282||Dec 14, 2005||Jan 11, 2011||Depuy Products, Inc.||Modular implant system and method with diaphyseal implant and adapter|
|US7881768||Apr 24, 2007||Feb 1, 2011||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|US7887565||Feb 18, 2006||Feb 15, 2011||Warsaw Orthopedic, Inc.||Apparatus and method for sequential distraction|
|US7914530||Apr 25, 2006||Mar 29, 2011||Warsaw Orthopedic, Inc.||Tissue dilator and method for performing a spinal procedure|
|US7914554||Mar 15, 2002||Mar 29, 2011||Warsaw Orthopedic, Inc.||Spinal implant containing multiple bone growth promoting materials|
|US7918382||Apr 18, 2005||Apr 5, 2011||Zimmer Technology, Inc.||Method for attaching a porous metal layer to a metal substrate|
|US7935116||Nov 25, 2008||May 3, 2011||Gary Karlin Michelson||Implant for the delivery of electrical current to promote bone growth between adjacent bone masses|
|US7942933||Apr 3, 2010||May 17, 2011||Warsaw Orthopedic, Inc.||Frusto-conical spinal implant|
|US7976566||Mar 25, 2002||Jul 12, 2011||Warsaw Orthopedic, Inc.||Apparatus for insertion into an implantation space|
|US7981158||Jun 9, 2008||Jul 19, 2011||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US7993347||Jul 27, 2000||Aug 9, 2011||Warsaw Orthopedic, Inc.||Guard for use in performing human interbody spinal surgery|
|US7998523||Oct 12, 2006||Aug 16, 2011||Smith And Nephew Orthopaedics Ag||Open-pore biocompatible surface layer for an implant, methods of production and use|
|US8021427||Jul 16, 2010||Sep 20, 2011||Mark Spoonamore||Intervertebral disk prosthesis with elastomeric insert|
|US8021430||Sep 7, 2010||Sep 20, 2011||Warsaw Orthopedic, Inc.||Anatomic spinal implant having anatomic bearing surfaces|
|US8021432||Oct 11, 2006||Sep 20, 2011||Biomet Manufacturing Corp.||Apparatus for use of porous implants|
|US8029573||Dec 7, 2006||Oct 4, 2011||Ihip Surgical, Llc||Method and apparatus for total hip replacement|
|US8036729||Jan 22, 2004||Oct 11, 2011||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|US8057475||Nov 9, 2010||Nov 15, 2011||Warsaw Orthopedic, Inc.||Threaded interbody spinal fusion implant|
|US8062302||Jun 9, 2008||Nov 22, 2011||Conformis, Inc.||Surgical tools for arthroplasty|
|US8066705||Feb 21, 2003||Nov 29, 2011||Warsaw Orthopedic, Inc.||Instrumentation for the endoscopic correction of spinal disease|
|US8066708||Feb 6, 2007||Nov 29, 2011||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8066778||Feb 22, 2007||Nov 29, 2011||Biomet Manufacturing Corp.||Porous metal cup with cobalt bearing surface|
|US8077950||Aug 10, 2010||Dec 13, 2011||Conformis, Inc.||Methods for determining meniscal size and shape and for devising treatment|
|US8083745||Mar 14, 2008||Dec 27, 2011||Conformis, Inc.||Surgical tools for arthroplasty|
|US8100982||Dec 14, 2005||Jan 24, 2012||Depuy Products, Inc.||Modular diaphyseal and collar implant|
|US8105330||Jun 9, 2008||Jan 31, 2012||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8112142||Jun 27, 2007||Feb 7, 2012||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|US8114156 *||Mar 12, 2009||Feb 14, 2012||Edwin Burton Hatch||Flexibly compliant ceramic prosthetic meniscus for the replacement of damaged cartilage in orthopedic surgical repair or reconstruction of hip, knee, ankle, shoulder, elbow, wrist and other anatomical joints|
|US8122582||Jan 28, 2009||Feb 28, 2012||Conformis, Inc.||Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty|
|US8123814||Jun 26, 2007||Feb 28, 2012||Biomet Manufacturing Corp.||Method and appartus for acetabular reconstruction|
|US8133553||Jun 18, 2007||Mar 13, 2012||Zimmer, Inc.||Process for forming a ceramic layer|
|US8142510||Mar 17, 2008||Mar 27, 2012||Depuy Products, Inc.||Mobile bearing assembly having a non-planar interface|
|US8142886||Jul 24, 2008||Mar 27, 2012||Howmedica Osteonics Corp.||Porous laser sintered articles|
|US8147557||Mar 30, 2007||Apr 3, 2012||Depuy Products, Inc.||Mobile bearing insert having offset dwell point|
|US8147558||Mar 17, 2008||Apr 3, 2012||Depuy Products, Inc.||Mobile bearing assembly having multiple articulation interfaces|
|US8147861||Aug 15, 2006||Apr 3, 2012||Howmedica Osteonics Corp.||Antimicrobial implant|
|US8152856||Mar 29, 2010||Apr 10, 2012||Nobel Biocare Ab (Publ.)||Layer arranged on implant for bone or tissue structure, such an implant, and a method for application of the layer|
|US8191760||Feb 15, 2011||Jun 5, 2012||Zimmer Technology, Inc.||Method for attaching porous metal layer to a metal substrate|
|US8197550||Sep 14, 2009||Jun 12, 2012||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US8206387||Apr 21, 2011||Jun 26, 2012||Gary Karlin Michelson||Interbody spinal implant inductively coupled to an external power supply|
|US8211183||Mar 16, 2011||Jul 3, 2012||Ihip Surgical, Llc||Methods and systems for total hip replacement|
|US8221499||Jan 25, 1999||Jul 17, 2012||Biomet 3I, Llc||Infection-blocking dental implant|
|US8226652||Nov 14, 2011||Jul 24, 2012||Warsaw Orthopedic, Inc.||Threaded frusto-conical spinal implants|
|US8234097||Feb 24, 2010||Jul 31, 2012||Conformis, Inc.||Automated systems for manufacturing patient-specific orthopedic implants and instrumentation|
|US8241357||Apr 25, 2007||Aug 14, 2012||Jmea Corporation||Prosthesis with a selectively applied bone growth promoting agent|
|US8251700||May 12, 2004||Aug 28, 2012||Biomet 3I, Llc||Surface treatment process for implants made of titanium alloy|
|US8251997||Nov 29, 2011||Aug 28, 2012||Warsaw Orthopedic, Inc.||Method for inserting an artificial implant between two adjacent vertebrae along a coronal plane|
|US8257395||Sep 21, 2007||Sep 4, 2012||Jmea Corporation||Spinal fixation with selectively applied bone growth promoting agent|
|US8265730||Jun 15, 2001||Sep 11, 2012||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and preventing damage|
|US8266780||Feb 27, 2008||Sep 18, 2012||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US8268100||Jul 26, 2010||Sep 18, 2012||Howmedica Osteonics Corp.||Laser-produced porous surface|
|US8292967||Dec 5, 2005||Oct 23, 2012||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US8306601||Aug 13, 2011||Nov 6, 2012||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|US8309521||Jun 19, 2007||Nov 13, 2012||Zimmer, Inc.||Spacer with a coating thereon for use with an implant device|
|US8328874||Mar 17, 2008||Dec 11, 2012||Depuy Products, Inc.||Mobile bearing assembly|
|US8337501||May 10, 2010||Dec 25, 2012||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8337507||Dec 22, 2008||Dec 25, 2012||Conformis, Inc.||Methods and compositions for articular repair|
|US8343188||Apr 23, 2012||Jan 1, 2013||Warsaw Orthopedic, Inc.||Device and method for locking a screw with a bendable plate portion|
|US8343218||Dec 22, 2008||Jan 1, 2013||Conformis, Inc.||Methods and compositions for articular repair|
|US8350186||Dec 29, 2006||Jan 8, 2013||Howmedica Osteonics Corp.||Laser-produced implants|
|US8353909||Apr 25, 2006||Jan 15, 2013||Warsaw Orthopedic, Inc.||Surgical instrument for distracting a spinal disc space|
|US8366771||May 10, 2010||Feb 5, 2013||Conformis, Inc.||Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty|
|US8369926||Jan 31, 2011||Feb 5, 2013||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|US8377129||Oct 27, 2009||Feb 19, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8409292||May 17, 2011||Apr 2, 2013||Warsaw Orthopedic, Inc.||Spinal fusion implant|
|US8409294||Feb 26, 2009||Apr 2, 2013||Depuy (Ireland)||Cup component of an orthopaedic joint prosthesis|
|US8439926||Mar 5, 2009||May 14, 2013||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8444696||Sep 19, 2011||May 21, 2013||Warsaw Orthopedic, Inc.||Anatomic spinal implant having anatomic bearing surfaces|
|US8444699 *||Feb 18, 2010||May 21, 2013||Biomet Manufacturing Corp.||Method and apparatus for augmenting bone defects|
|US8460304||Oct 27, 2009||Jun 11, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8480754||Feb 25, 2010||Jul 9, 2013||Conformis, Inc.||Patient-adapted and improved articular implants, designs and related guide tools|
|US8500740||Apr 16, 2010||Aug 6, 2013||Conformis, Inc.||Patient-specific joint arthroplasty devices for ligament repair|
|US8506642 *||Apr 24, 2006||Aug 13, 2013||Philip Scott Lyren||Hip implant with porous body|
|US8529630||Sep 24, 2012||Sep 10, 2013||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8535385 *||Aug 8, 2011||Sep 17, 2013||Zimmer, Inc.||Prosthetic implant support structure|
|US8545569||Jan 5, 2004||Oct 1, 2013||Conformis, Inc.||Patient selectable knee arthroplasty devices|
|US8551099||May 10, 2010||Oct 8, 2013||Conformis, Inc.||Surgical tools for arthroplasty|
|US8551102||Sep 24, 2012||Oct 8, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8551103||Sep 24, 2012||Oct 8, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8551169||Sep 24, 2012||Oct 8, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8551181||Feb 27, 2012||Oct 8, 2013||Biomet Manufacturing, Llc||Method and apparatus for acetabular reconstruction|
|US8556906||Sep 24, 2012||Oct 15, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8556907||Sep 24, 2012||Oct 15, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8556983||Mar 9, 2011||Oct 15, 2013||Conformis, Inc.||Patient-adapted and improved orthopedic implants, designs and related tools|
|US8561278||Sep 24, 2012||Oct 22, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8562611||Sep 24, 2012||Oct 22, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8562618||Sep 24, 2012||Oct 22, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8568479||Sep 24, 2012||Oct 29, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8568480||Sep 24, 2012||Oct 29, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8579985||Dec 22, 2011||Nov 12, 2013||Ihip Surgical, Llc||Method and apparatus for hip replacement|
|US8585708||May 11, 2010||Nov 19, 2013||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8585770||Jul 12, 2011||Nov 19, 2013||Biomet Manufacturing, Llc||Implant sleeve for cement hip stems|
|US8602290||Apr 22, 2011||Dec 10, 2013||Zimmer, Inc.||Method for bonding a tantalum structure to a cobalt-alloy substrate|
|US8608049||Oct 10, 2007||Dec 17, 2013||Zimmer, Inc.||Method for bonding a tantalum structure to a cobalt-alloy substrate|
|US8617172||Jul 20, 2012||Dec 31, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8617242||Feb 14, 2008||Dec 31, 2013||Conformis, Inc.||Implant device and method for manufacture|
|US8623026||Aug 10, 2011||Jan 7, 2014||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief|
|US8634617||Dec 6, 2011||Jan 21, 2014||Conformis, Inc.||Methods for determining meniscal size and shape and for devising treatment|
|US8641716||Jul 19, 2012||Feb 4, 2014||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US20110202141 *||Feb 18, 2010||Aug 18, 2011||Biomet Manufacturing Corp.||Method and apparatus for augmenting bone defects|
|US20110295382 *||Aug 8, 2011||Dec 1, 2011||Zimmer, Inc.||Prosthetic implant support structure|
|USRE43282||Aug 19, 2008||Mar 27, 2012||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|DE3527136A1 *||Jul 29, 1985||Mar 13, 1986||Bristol Myers Co||Implantat und verfahren zur herstellung desselben|
|DE3527136C2 *||Jul 29, 1985||Apr 13, 1989||Bristol-Myers Co., New York, N.Y., Us||Title not available|
|DE3822153C2 *||Jun 30, 1988||Feb 8, 2001||Bristol Myers Squibb Co||Femoralkomponente für eine Hüftprothese|
|DE3909545A1 *||Mar 22, 1989||Oct 5, 1989||Bristol Myers Co||Knochenimplantat|
|DE3909545C2 *||Mar 22, 1989||Oct 1, 1998||Squibb Bristol Myers Co||Knochenimplantat|
|DE4133877C1 *||Oct 12, 1991||May 19, 1993||S + G Implants Gmbh, 2400 Luebeck, De||Title not available|
|EP0008758A1||Aug 27, 1979||Mar 19, 1980||Metallwerk Plansee Gesellschaft M.B.H.||Process for the manufacture of an intramedullary nail|
|EP0075378A1 *||Apr 14, 1982||Mar 30, 1983||Crucible Materials Corporation||Prosthesis device and method of manufacture|
|EP0149527A2 *||Jan 10, 1985||Jul 24, 1985||University Of Exeter||Fixation of implants in bone|
|EP0162604A1 *||Apr 25, 1985||Nov 27, 1985||Minnesota Mining And Manufacturing Company||Implant with attachment surface|
|EP0191152A1 *||Nov 19, 1985||Aug 20, 1986||Gebrüder Sulzer Aktiengesellschaft||Metallic implant for bones|
|EP0202031A2 *||Apr 15, 1986||Nov 20, 1986||Richards Medical Company||Chemical polishing process for titanium and titanium alloy surgical implants|
|EP0388576A1 *||Nov 9, 1989||Sep 26, 1990||Institut Straumann Ag||Metallic implant|
|EP1229147A1 *||Jan 23, 2002||Aug 7, 2002||Tecomet Inc.||Method for producing undercut recesses in a surface, a surgical implant made thereby and a method for fixing an implant to bone|
|EP2292188A2||Nov 25, 2003||Mar 9, 2011||Conformis, Inc.||Patient selectable surgical tools|
|EP2292189A2||Nov 25, 2003||Mar 9, 2011||Conformis, Inc.||Patient selectable surgical tools|
|EP2324799A2||Nov 22, 2005||May 25, 2011||Conformis, Inc.||Patient selectable knee joint arthroplasty devices|
|EP2335654A1||Nov 24, 2004||Jun 22, 2011||Conformis, Inc.||Patient selectable knee joint arthoplasty devices|
|EP2397110A1||Jun 24, 2004||Dec 21, 2011||BIEDERMANN MOTECH GmbH||Tissue integration design for seamless implant fixation|
|EP2520255A1||Nov 21, 2006||Nov 7, 2012||Vertegen, Inc.||Devices and methods for treating facet joints, uncovertebral joints, costovertebral joints and other joints|
|EP2649951A2||Feb 6, 2007||Oct 16, 2013||ConforMIS, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|EP2671520A2||Feb 6, 2007||Dec 11, 2013||ConforMIS, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|EP2671521A2||Feb 6, 2007||Dec 11, 2013||ConforMIS, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|EP2671522A2||Feb 6, 2007||Dec 11, 2013||ConforMIS, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|WO1986006617A1 *||May 7, 1986||Nov 20, 1986||Plasmainvent Ag||Coating of an implant body|
|WO1990009154A1 *||Feb 15, 1990||Aug 23, 1990||Furlong Res Found||Femoral prosthesis|
|WO1993016656A2 *||Feb 18, 1993||Sep 2, 1993||Joint Medical Products Corp||Sintered coatings for implantable prostheses|
|WO1997028760A1 *||Feb 10, 1997||Aug 14, 1997||Wilfried Schilli||Pin or screw-like securing device for osteosynthesis|
|WO2011004217A1 *||Jul 7, 2009||Jan 13, 2011||Eurocoating S.P.A.||Process for depositing a coating on metal or non- metal items, and item obtained therefrom|
| || |
|U.S. Classification||623/23.55, 428/613, 433/172, 428/610, 428/636|
|International Classification||B22F7/00, A61F2/30, A61F2/00|
|Cooperative Classification||A61F2310/00023, A61F2310/00407, A61F2/30767, B22F7/002|
|European Classification||A61F2/30L, B22F7/00B|
|Nov 14, 1997||AS||Assignment|
Owner name: AMERICAN STANDARD, INC., NEW JERSEY
Free format text: RELEASE OF SECURITY INTEREST;ASSIGNOR:CHASE MANHATTAN BANK, THE (FORMERLY KNOWN AS CHEMICAL BANK);REEL/FRAME:008869/0001
Effective date: 19970801
|Nov 13, 1997||AS||Assignment|
Owner name: AMERICAN STANDARD, INC., NEW JERSEY
Free format text: RELEASE OF SECURITY INTEREST (RE-RECORD TO CORRECT DUPLICATES SUBMITTED BY CUSTOMER. THE NEW SCHEDULE CHANGES THE TOTAL NUMBER OF PROPERTY NUMBERS INVOLVED FROM 1133 TO 794. THIS RELEASE OF SECURITY INTEREST WAS PREVIOUSLY RECORDED AT REEL 8869, FRAME 0001.);ASSIGNOR:CHASE MANHATTAN BANK, THE (FORMERLY KNOWN AS CHEMICAL BANK);REEL/FRAME:009123/0300
Effective date: 19970801
|Jun 2, 1993||AS||Assignment|
Owner name: CHEMICAL BANK, AS COLLATERAL AGENT, NEW YORK
Free format text: ASSIGNMENT OF SECURITY INTEREST;ASSIGNOR:BANKERS TRUST COMPANY, AS COLLATERAL TRUSTEE;REEL/FRAME:006565/0753
Effective date: 19930601
|Jun 28, 1988||AS||Assignment|
Owner name: BANKERS TRUST COMPANY
Free format text: SECURITY INTEREST;ASSIGNOR:AMERICAN STANDARD INC., A DE. CORP.,;REEL/FRAME:004905/0035
Effective date: 19880624