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Publication numberUS3607098 A
Publication typeGrant
Publication dateSep 21, 1971
Filing dateOct 17, 1968
Priority dateOct 23, 1967
Also published asDE1803281A1, DE1803281B2, DE1803281C3
Publication numberUS 3607098 A, US 3607098A, US-A-3607098, US3607098 A, US3607098A
InventorsCarl Sloth Strande
Original AssigneeCarl Sloth Strande
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Containers for laboratory use
US 3607098 A
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Description  (OCR text may contain errors)

United States Patent CONTAINERS FOR LABORATORY USE 6 Claims, 1 Drawing Fig.

U.S. Cl 23/259, 215/41 Int. Cl B01l 3/14, 865d 41/20 Field of Search 23/259,

292; 215/41, DIG. 3, 37, 38

[56] References Cited UNITED STATES PATENTS 2,693,892 11/1954 Guinet 215/41 Primary Examiner-Morris O.- Wolk Assistant Examiner-R. M. Reese Attorney-Michael S. Striker ABSTRACT: A container having an upper open end through which the container can be filled with liquid, such as a specimen of blood, and a closure fluid-tightly closing the open end of the container. The closure has a portion within the opening which is pierceable by a sedimentation tube or the like and the portion of the closure within the opening is constructed to close fluid-tightly about the outer surface of the tube when the latter is pushed through the closure.

PATENTED am] 1921 3,607,098

INVENTOR a 160m 24004 ATTORNEY CONTAINERS FOR LABORATORY USE This invention relates to a container for laboratory use, particularly but not exclusively for use in collecting blood for sedimentation tests, i.e. determining the rate of sinking of blood corpuscles.

For various purposes in medicine, including veterinary medicine, a large number of experiments are carried out with blood, urine and other liquids, and it is important for the sake of efiiciency that the many small specimens of liquid be easily protected and transported and subsequently be readily available for use.

When it is required to measure the rate of sinking of blood corpuscles, transfer of a mixture of blood and citrate solution from a specimen in a glass container to a sedimentation tube is effected by dipping the sedimentation tube into the specimen and then by mouth sucking the mixture into the sedimentation tube to a height of a little more than 200 mms. The sedimentation tube is then closed with a finger and by means of the finger the height of the mixture is adjusted to 200 mm. after which the sedimentation tube is placed in a frame. This wellknown method is diflicult to operate, is repulsive to some persons and involves the danger that one may easily suck the mixture into ones mouth and therefore expose oneself to disease, e.g. infectious jaundice.

Numerous attempts have been made to avoid the sucking of the mixture into the sedimentation tubes without a method being found which, in practice, does not result in increased exenses. For example, the sedimentation tube has been provided with a nonreturn valve, which is not only expensive but also makes it difficult to fill the sedimentation tube to the correct height and in particular to clean the sedimentation tube after use. lntemally ground cylinders have also been proposed which have a diameter such that the sedimentation tube upon being inserted into the cylinder, acts as a piston so that the mixture is pressed upwardly into the tube. Such cylinders are expensive and therefore cannot be thrown away after use but must be cleaned. Also, without additional measures, they are not suited for transporting a specimen.

The present invention provides a container for laboratory use, having a closure which has a thick peripheral part adapted to tighten against an edge of the container and having a thinner middle part adapted to tighten around a sedimentation tube or pipette upon being pierced by such tube or pipette.

This arrangement ensures that the liquid, which is tightly enclosed in the container and which can therefore be readily transported, can be removed in the desired amounts from the container by insertion of a sedimentation tube or a pipette into the container, the liquid being forced into the sedimentation tube or the pipette following the insertion thereof. Moreover, it ensures that the laboratory technician does not get into contact with the liquid. The container, together with the remaining liquid, may be thrown away after use.

The container is particularly suited for collecting blood for measurement of the rate of sinking of the blood corpuscles, in which case the container, together with the inserted sedimentation tube can be placed in a frame until the sedimentation test has been completed, after which both can be thrown away. Instead of this, the sedimentation tube can be drawn from the container, whereby the surface of the sedimentation tube is cleaned of the fluid mixture by its passage through the closure, while the container with its blood and citrate may be thrown away.

According to the invention the diameter of the thinner middle part of the closure may correspond to the outer diameter of asedimentation tube, so that the thinner middle part by insertion of a sedimentation tube into the container is pressed apart and the sedimentation tube bears against the inner side of the peripheral part of the closure to ensure good sealing.

To facilitate the insertion of the sedimentation tube, the middle part of the closure may have a rupturing mark.

The middle part of the container may have a wall thickness which is so small that this part is resilient and can be pressed together, so that liquid can be readil pressed up from the contamer into, for example, a pipette. a sedimentation tube is to be filled with blood from the container the required height of liquid in the sedimentation tube can be adjusted by squeezing the middle part of the container.

The invention is illustrated in the drawing, which shows a vertical, longitudinal section through one embodiment of the container.

A container 1 is made of a suitable plastics material and is provided with an opening defined by annular wall and with a closure 2 which closes the opening of the container in an air: tight manner since the closure 2 has a thick peripheral part adapted to close tightly around the outer surface of the annu lar wall of the container. The closure 2 also has a thin middle part 5 which can be pierced by a sedimentation tube or a pipette. The closure has a substantial inner frustoconical part 6, located within the opening spaced from the inner surface of the annular wall and which is closed at the bottom by the mid dle part 5 and against the inner side of which the sediment..- tion tube can bear so that good sealing is obtained by insertion of the sedimentation tube. The upper part 4 of the container has a wall thickness which is sufficiently large to ensure that when the closure is fitted good sealing can be obtained, the upper part of the container having a corresponding stiffness. The middle part of the container has a wall thickness which is so small that this part can be easily pressed together, whereby for example liquid can be pressed upward to exactly the required height in a sedimentation tube. The position at which the large and small wall thicknesses meet each other can indicate the height which the mixture of blood and citrate solution should reach in the container. The lower part or bottom 3 of the container has such a shape that it fits closely around the tip or lower part of the sedimentation tube. In this way sufficient sealing is obtained to ensure that when the sedimentation tube is pushed right into the container the mixture of blood and citrate solution remains at the same height in the sedimentation tube until the rate of sinking of the blood corpuscles is measured.

What we claim is:

l. A device for laboratory use comprising a container having an opening defined by an annular wall having an outer surface; and closure means for tightly closing said opening, said closure means having an outer peripheral part tightly engaging said outer surface of said annular wall and wall means within said opening integral with said outer part, and a thin pierceable bottom portion integral with said wall means so as to close said opening, said bottom portion having a wall thickness smaller than that of said outer part, and said wall means being constructed to close fluidtightly about a sedimentation tube when said bottom portion is pierced by said tube.

2. A device as defined in claim 1, wherein said wall means comprise an inner frustoconical part which is closed at the bottom by said pierceable bottom portion, said frustoconical part having an outer surface radially inwardly spaced from the inner surface of said annular wall.

3. A device as defined in claim 2, wherein said pierceable bottom portion and the sedimentation tube to be inserted into said container have substantially equal outer diameters.

4. A device as defined in claim 1, wherein said container has spaced from said annular wall defining said opening a flexible wall portion.

5. A device as defined in claim 4, wherein said container is substantially cylindrical, and wherein said flexible wall portion is an annular wall portion.

6. A device as defined in claim 5, wherein said container has a closed bottom end portion having an inner cylindrical surface of a diameter to tightly engage about a sedimentation tube extending downwardly in said container in engagement with said bottom end portion of the latter.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2693892 *Jun 28, 1950Nov 9, 1954William Jacques HerterContainer sealing means
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US4024857 *Dec 11, 1975May 24, 1977Becton, Dickinson And CompanyMicro blood collection device
US4056361 *Jun 11, 1976Nov 1, 1977The Secretary Of State For Social Services In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern IrelandVial or other container, and carrier therefor
US4106907 *Feb 3, 1977Aug 15, 1978The Radiochemical Centre LimitedCentrifuge tube and method for performing assay with same
US4215700 *Aug 25, 1978Aug 5, 1980Sherwood Medical Industries Inc.Blood collection device
US4278437 *Apr 9, 1979Jul 14, 1981Jan HaggarFluid specimen holder for biological fluid testing
US4308028 *Apr 14, 1980Dec 29, 1981Elkins Carlos DDevice and method for the chemical testing and microscopic examination of liquid specimens
US4652429 *Jan 10, 1985Mar 24, 1987C. A. Greiner & Sohne Gesellschaft M.B.H.Biological sampling tube
US4769335 *Dec 2, 1985Sep 6, 1988Ncs Diagnostics Inc.Method and apparatus for transporting photosensitive fluids
US4799599 *Jul 30, 1982Jan 24, 1989Ciba Corning Diagnostics Corp.Specimen cup and cap assembly for clinical analyzer
US4933145 *Jun 3, 1988Jun 12, 1990Terumo Kabushiki KaishaAdding organic acid to adjust ph
US4960219 *Sep 8, 1989Oct 2, 1990Abbott LaboratoriesSnap cap
US5092855 *Jan 22, 1990Mar 3, 1992Reseal International Limited PartnershipEnclosing sleeve for one-way valve
US5224515 *Jan 30, 1992Jul 6, 1993Porex Technologies Corp.Tube closure
US5285253 *Aug 16, 1991Feb 8, 1994Bernd KlothCuvette for holding substances to be analyzed by optical means
US5573567 *Dec 12, 1995Nov 12, 1996Shigemi Co., Ltd.Method of manufacturing sample tube for nuclear magnetic resonance
US5602756 *Dec 8, 1995Feb 11, 1997The Perkin-Elmer CorporationThermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5795784 *Sep 19, 1996Aug 18, 1998Abbott LaboratoriesMethod of performing a process for determining an item of interest in a sample
US5856194 *Sep 19, 1996Jan 5, 1999Abbott LaboratoriesMethod for determination of item of interest in a sample
US5881596 *Sep 28, 1994Mar 16, 1999Itochu CorporationUrine sampling vessel
US5915583 *May 21, 1997Jun 29, 1999Abbott LaboratiesFor holding a patient sample
US5916525 *Dec 3, 1992Jun 29, 1999Eppendorf-Netheler-Hinz GmbhFor use inlaboratory work at extreme temperatures, excellent sealing charactaristics; as a safty vessel for storage and transporting fluid; as a vessel for denaturation of albumin in water bath
US6015534 *Apr 14, 1995Jan 18, 2000The Perkin-Elmer CorporationPCR sample tube
US6056925 *Nov 18, 1997May 2, 2000Sarstedt Ag & Co.Sample vessel for taking blood samples
US6562298Apr 23, 1999May 13, 2003Abbott LaboratoriesStructure for determination of item of interest in a sample
US6660228 *Dec 21, 1999Dec 9, 2003CepheidApparatus for performing heat-exchanging, chemical reactions
US6716396Nov 1, 2000Apr 6, 2004Gen-Probe IncorporatedAperture defined by inner circumference of annular top wall; inner wall with plurality of striations extending radial; leak-proof seal; clinical analysis and diagnosis vessel
US6723289May 18, 2001Apr 20, 2004Gen-Probe IncorporatedPenetratable cap allows withdrawal of fluid via pippette without removal of lid; contamination minimization
US6806094Mar 29, 2001Oct 19, 2004Gen-Probe IncorporatedMethod for removing a fluid substance from a collection device
US6893612Mar 8, 2002May 17, 2005Gen-Probe IncorporatedTransfer fluids to or from a fluid-holding vessel, and remain physically and sealably associated during transfer
US7276383Apr 18, 2003Oct 2, 2007Gen-Probe IncorporatedRelates to a cap penetrable by a fluid transfer device used to transfer fluids to or from a fluid- holding vessel, where the vessel and cap remain physically and sealably associated during a fluid transfer
US7294308Sep 29, 2004Nov 13, 2007Gen-Probe IncorporatedPenetrable cap
US7306129Nov 3, 2005Dec 11, 2007Stewart SwissOne way valve assembly
US7309469Nov 17, 2003Dec 18, 2007Gen-Probe IncorporatedOpened vessel; cap configurated to position sample in interior of vessel
US7435389Jan 14, 2004Oct 14, 2008Gen-Probe IncorporatedSealed collection device having striated cap
US7462323Nov 21, 2003Dec 9, 2008CepheidApparatus for performing heat-exchanging chemical reactions
US7513396Dec 3, 2007Apr 7, 2009Reseal International Limited PartnershipOne way valve assembly
US7648680Oct 26, 2004Jan 19, 2010Gen-Probe IncorporatedMethod for accessing the contents of a closed vessel containing a specimen retrieval device
US7691332Oct 9, 2007Apr 6, 2010Gen-Probe IncorporatedPenetrable cap
US7795036Oct 18, 2007Sep 14, 2010Gen-Probe IncorporatedUsing air displacement pipette to isolate and analyze fluids in closed reaction vessel; recovering nucleic acid ampification products
US7824922Mar 26, 2009Nov 2, 2010Gen-Probe IncorporatedUsing cap comprising frangible seal which is penetrable by a plastic pipette which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis
US7927549Oct 30, 2007Apr 19, 2011Gen-Probe IncorporatedMethod for accessing the contents of a closed collection device with a modified pipette tip
US8038967Apr 23, 2010Oct 18, 2011Gen-Probe IncorporatedMethod for accessing the contents of a closed vessel containing a specimen retrieval device
US8052944Apr 1, 2010Nov 8, 2011Gen-Probe IncorporatedPenetrable cap
US8057762Dec 2, 2010Nov 15, 2011Gen-Probe IncorporatedPenetrable cap
US8177084Feb 13, 2006May 15, 2012Tripath Imaging, Inc.Container assembly and pressure-responsive penetrable cap for the same
US8206662Oct 29, 2007Jun 26, 2012Gen-Probe IncorporatedApparatus comprising cap penetratable by air displacement pipette for use in monitoring biological fluids
US8211710Oct 30, 2007Jul 3, 2012Dickey Kathleen AUsing air displacement pipette to isolate and analyze fluids in closed reaction vessel; recovering nucleic acid ampification products
US8334145Jul 21, 2008Dec 18, 2012Gen-Probe IncorporatedPierceable cap having spaced-apart grooves
US8535621Jun 17, 2008Sep 17, 2013Gen-Probe IncorporatedPenetrable cap having rib structures
US8573072Aug 18, 2009Nov 5, 2013Gen-Probe IncorporatedMethod for removing a fluid substance from a sealed collection device
US8685347Nov 15, 2011Apr 1, 2014Gen-Probe IncorporatedPenetrable cap
Classifications
U.S. Classification422/550, 422/913, D24/224, 215/317, 356/246, 215/247
International ClassificationB01L3/14
Cooperative ClassificationB01L3/5082
European ClassificationB01L3/5082