|Publication number||US3608539 A|
|Publication date||Sep 28, 1971|
|Filing date||Nov 6, 1968|
|Priority date||Nov 6, 1968|
|Publication number||US 3608539 A, US 3608539A, US-A-3608539, US3608539 A, US3608539A|
|Inventors||Miller Daniel G|
|Original Assignee||Miller Daniel G|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (5), Referenced by (134), Classifications (7)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent  lnventor Daniel G. Miller 430 E. 86th St., New York, N.Y. 10028  Appl. No. 773,787  Filed Nov. 6, 1968  Patented Sept. 28, 1971  METHOD FOR THE BIOPSY OF SUBCUTANEOUS MASSES 6 Claims, 9 Drawing Figs.
 11.8. CI. 128/2, 128/314, 128/329, 128/347  Int. Cl ..A61bl0/00, A61b 17/34, A61b 17/32  Field of Search 128/2, 305, v 314, 329, 347
 References Cited UNITED STATES PATENTS 2,919,692 l/1960 v Ackermann 128/314 X 3,342,175 9/1967 Bulloch 128/2 1,485,298 2/l924 Schroyer 128/347 UX 2,865,374 12/1958 Brown et al.... 128/347 X 3,496,932 2/1970 Prisk et a1. 129/347 X Primary Examiner-Channing L. Pace Attorney-Howard C. Miskin ABSTRACT: An instrument for the biopsy of subcutaneous masses includes an arcuate cannula having a serrated distal cutting end and is provided for alternative insertion, a correspondingly curved pointed stylet and a flexible ejector element. In performing a biopsy, and the skin is punctured and the cannula engaged stylet inserted through the puncture into the surface of the mass from its lateral or inferior aspect. The stylet is removed and the cannula advanced through the mass to cut and draw a specimen thereof into the cannula and the cannula is pushed through the overlying tissue to the skin. which is then punctured and the distal end of the cannula pushed through the puncture. The ejector is then pushed through the proximal end of the cannula to eject the specimen.
PATENTED SEP28I9TI 3.808.539
SHEET 1 BF 2 INVEN'I'OR. DANIEL G. MILLER AT TORNEY PATENTED SEP28 I97! 3.608.539
sum 2 0F 2 EN'I'UR. DAME MILLER ATTORNEY METHOD FOR THE BIOPSY OF SUBCUTANEOUS MASSES BACKGROUND OF THE INVENTION The present invention relates generally to improvements in sampling methods and instruments and it relates particularly to an improved method and instrument for obtaining biopsy specimens from subcutaneous masses, such as lymph nodes or tumors. I
The procedures conventionally employed for obtaining biopsy specimens pose numerous drawbacks and disadvantages, particularly when applied to subcutaneous masses. They are usually accompanied by damage to the surrounding tissue as the result of surgical incision and disection, and frequently effect the transfer of some of the sampled mass to the surrounding tissue, a consequence which is highly undesirable and should be assiduously avoided. Moreover, when straight needles are employed to obtain biopsies of lymph nodes or subcutaneous masses, the plug which is impaled in the barrel, in most instances will remain in situ when the needle is withdrawn, because its distal end has not been severed from the bulk of the mass. These tissues possess an inherent elasticity and connective tissue framework, which is resilient and has sufficient strength to retain a specimen which is cut on only three sides. It is because of this common experience that needles previously used for this purpose employed various undercutting mechanisms for retaining the cut plug, e.g. a screw, a hook, compressible jaws or a side cutting device.
SUMMARY OF THE INVENTION It is a principal object of the present invention to provide an improved sampling method and instrument.
Another object of the present invention is to provide an improved method and instrument for obtaining biopsy specimens.
Still another object of the presentinvention is to provide an improved method and instrument for obtaining biopsy specimens of subcutaneous masses.
A further object of the present invention is to provide an improved method and instrument for obtaining biopsy specimens of subcutaneous masses with a minimum of damage to the surrounding tissue and the obviation of any transfer of the sampled mass to the surrounding tissue.
Still a further object of the present invention is to provide a method of the above nature, characterized by its convenience, simplicity, high reliability, versatility and minimum discomforture to the subject.
The above and other objects of the present invention will become apparent from a reading of the following description taken in conjunction with the accompanying drawing, which illustrates a preferred embodiment thereof.
In a sense the present invention contemplates the provision of the method for obtaining a biopsy of a subcutaneous masscomprising the steps of advancing a curved cannula through a first area of the skin, through said mass to cut and receive a specimen thereof, and thence through a second area of the skin, and thereafter ejecting said specimen from said cannula while projecting through the skin of the second area. The cannula is advantageously curved and preferably arcuate with a radius of curvature advantageously between 3 and centimeters and advantageously extends between 45 and 180 preferably between 120 and 130, and is of a length between 5 and 12 centimeters. The distal end of the cannula is provided with a serrated cutting edge and the proximal end is provided with finger engageable wings. A similarly curved stylet is slidably received within the cannula and is provided with a proximal button and a distal pointed tip projecting through the cannula distal end. A blunt ended flexible ejector is slidably received within the cannula alternatively with the stylet. According to the preferred procedure, the skin on one side of the mass is punctured and the stylet engaged cannula inserted therethrough and advanced into engagement with the mass. The stylet is then removed and the cannula advanced through The improved procedure is simple, rapid, convenient, versatile and reliable. It results in a minimum of damage to the surrounding tissue and prevents any transfer of the biopsied mass to the surrounding tissue.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a front elevational view of the cannula section of an instrument embodying the present invention;
FIG. 2 is a front elevational view of the stylet section thereof;
FIG. 3 is a front elevational view of the ejector section thereof;
FIG. 4 is a enlarged longitudinal sectional view of the distal end of the assembled instrument;
FIG. 5 is an elevational view illustrating a step of preparing the site in the practice of the improved process;
FIG. 6 illustrates the insertion of the cannula into the explored mass;
FIG. 7 illustrates the obtaining of the biopsy specimen;
FIG. 8 illustrates the preparation of the skin exit site; and
FIG. 9 illustrates the ejection of the biopsy specimen.
DESCRIPTION THE PREFERRED EMBODIMENT Referring now to the drawing, and particularly FIGS. 1 to 4 thereof, which illustrate an instrument embodying the present invention, the improved instrument includes a cannula 11, a stylet or piercing member 12, and an ejector member 13. The cannula 11 comprises an arcuate tubular body member or barrel 14, provided at its distal end with a sharp serrated cutting edge 16, as bestseen in FIG. I. The bore of the cannula barrel 14 is uniform throughout its length, the outer face at the distal end being tapered to the cutting edge 16.
An annulus 17 is fitted over the proximal end of the barrel 14 and a wing-shaped finger piece provided with a medial opening is also fitted over the proximal border of the barrel l4 and rests on the annulus 17. A standard Luer-lok receptacle or coupling collar 19engages the distal end of the barrel l4 and is affixed to the barrel 14 with the annulus l7 and finger piece 18, by soldering, welding or the like.
The stylet 12 includes an accurately shaped rod 20 of the same curvature as the cannula barrel l4, and is of lesser crosssectional diameter than the bore of the barrel 14. The rod 20 terminates at its distal end in an enlarged pointed tip 21 and is provided at its proximal end with a thumb rest or button 22. The cannula l1 and stylet 12 are so dimensioned that when the stylet 12 is fully inserted in the cannula 11, the button 22 rests on the coupling collar 19 and the tip 21 projects through the distal end of the cannula barrel 14 with its face forming a smooth continuous surface with the outside face of the cannula barrel distal border, as seen best in FIG. 4.
The ejector member 13, is a flexible rod or wire of an outside diameter, about equal to the inside diameter of the barrel l4, and is provided with a blunt distal end face 23. The ejector member 13 is advantageously formed of Teflon rod or other suitable material.
As a specific example, the cannula barrel 14 is formed of stainless steel with an inside diameter of 3 millimeters and an outside diameter of 4 millimeters. The overall length of the cannula barrel 14 is 10 centimeters and the chord distance from end to end is about 9 centimeters. It has a radius of curvature of about 4.5 cm. and extends for about 120. The taper leading to the cutting edge 16 is about 4 millimeters long. The rod 20 is stainless steel of 2 millimeters diameter and the conical tip 21 is 6 millimeter long.
Considering now the practice of the improved method employing the instrument described above, and referring to FIGS. 5-.-9 of the drawing, the skin S, about 2 centimeters from the mass M which is to be biopsied, is infiltrated with procaine and from this side additional procaine is injected subcutaneously about mass M. Skin S is punctured, as seen in FIG. 5, with a surgical blade 26 in an area slightly offset from the side of mass M. The opening in the skin is further enlarged by stretching with a small curved hemostat or pointed scissors, not shown. With the same instrument a tract is made to the mass M by penetration and separation of the subutaneous tissue. The cannula l l with the pointed stylet 12 in place is then inserted along the prepared tract and inserted into the side of or the undersurface of the mass M, as seen in P10. 6. The free hand can often assist by holding the mass. After entry has been confirmed by moving the cannula 11 and mass M as one, the pointed stylet 12 is removed. With the thumb of the free hand, the mass M is pushed down and in this manner the open cannula ll traverses one entire diameter of the mass M, as seen in H0. 7. ln some situations it is advantageous to rock the proximal end of the cannula to and fro; this turns serrated cutting edge 16 of barrel l4 and facilitates its passage through the mass M. When the mass M has been penetrated, the arc is further extended to raise the skin S at the opposite side of the mass M. With procaine, puncture and tract prepared as above, as seen in FIG. 8, the specimen loaded cannula 11 emerges. The clearing stylet or ejector 13 is inserted in the cannula 11, as shown in FIG. 9, and the specimen is picked up on either a square of blotting paper or with thumb forceps and dropped into a bottle containing the fixing solution. The cannula 11, is easily withdrawn by reversing the direction of the arc. Pressure is applied to the punctures for 2 minutes and two Band- Aids are applied to each of the two puncture sites and left in place for 24 hours.
In employing the improved instrument in the method described above, highly satisfactory biopsy specimens were obtained and the proper diagnosis made in a large number of patients. No false negative diagnosis were encountered. It is important to note that there were no complications associated with the improved procedure. The specimens biopsied represented a variety of lesions from the point of view of size, consistency and diagnosis and the improved method has proven sufficiently versatile to adapt to most of the situations encountered.
While there has been described and illustrated a preferred embodiment of the present invention, it is apparent that numerous alterations, omissions and additions may be made without departing from the spirit thereof.
What I claim is:
l. The method for obtaining a biopsy of a subcutaneous mass comprising the steps of advancing a cannula inwardly through a first area of the skin laterally of the area above the mass and through said mass to undercut and receive a specimen from said mass and thence advancing outwardly cannula with the specimen therein out through a second area of the skin, on the side of the area above the mass opposite the first area and thereafter ejecting said specimen from said cannula while projecting through said skin.
2. The method of claim 1 wherein said cannula is advanced through said first skin area to said mass, while engaged by a stylet provided with a pointed end positioned at the distal end of said cannula, and removing said stylet from said cannula prior to said cannula being advanced through said mass.
3. The method of claim 1 wherein said specimen is ejected through said cannula by advancing a plunger through said cannula.
4. The method of claim 1 including the step of puncturing said first area of said skin with a sharp instrument prior to the insertion of said cannula.
5. The method of claim 1, including the step of puncturing the skin at said second area following the penetration of the mass by the cannula and before the emergence of the cannula through said second area.
6. The method of claim 1, including the step of applying pressure to said mass through the surrounding tissue in a direction towards said cannula during the advance of said cannula through said mass.
mg? NITEE STATES PATENT @F'FECE (IERHFECATE @F GORREQTEGN Patent No. 3,608, 539 Dated Becember 13, 1971 It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:
Abstract: 1. 5 "ment. In performing a biopsy, and
the skin is punctured and" Change to ment. In performing a biopsy, the skin is punctured, end-- Column 2, 1.. l9 "Fig. t is e enlarged longitudinal" Change to Fig. t is an enlarged longitudinal-- Column 4, l. i i-l5 said mess and thence advancing outwardly cannula with the specimen therein out through second area of the skin, on the Change to --said mass and thence advancing said cannula with the specimen therein outwardly through a second area of the skin, on the-- Signed and sealed this 25th day of April 1%?2.
At to e L:
MJNARD MJLEJJ EMEJR. ROBERT GOTTSCHALK Attesting Officer Commissioner of Patents
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1485298 *||Apr 26, 1923||Feb 26, 1924||William O Schroyer||Embalming implement|
|US2865374 *||Sep 16, 1957||Dec 23, 1958||Sierra Eng Co||Tracheotomy instrument|
|US2919692 *||Feb 23, 1956||Jan 5, 1960||Wolfgang Ackermann||Vertebral trephine biopsy instruments|
|US3342175 *||Nov 23, 1964||Sep 19, 1967||Bulloch Robert T||Cardiac biopsy instrument|
|US3496932 *||Dec 22, 1967||Feb 24, 1970||Gen Motors Corp||Method and apparatus for substernal cardiac massage|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3870043 *||Mar 28, 1974||Mar 11, 1975||Dunn Allan R||U-shaped intravenous needle structure|
|US4013080 *||Jun 5, 1975||Mar 22, 1977||Froning Edward C||Cannula connector and direction indicator means for injection system|
|US4244370 *||Nov 20, 1978||Jan 13, 1981||American Medical Systems, Inc.||Tool for positioning implantable medical prosthetic device _and method of using same|
|US4493323 *||Dec 13, 1982||Jan 15, 1985||University Of Iowa Research Foundation||Suturing device and method for using same|
|US4530359 *||Feb 8, 1983||Jul 23, 1985||Helfgott Maxwell A||Ophthalmic perforating instrument and surgical method employing said instrument|
|US4684369 *||Aug 19, 1985||Aug 4, 1987||Wildemeersch Dirk A A||Instrument for suprapubic drainage of the bladder, inserted through the urethra|
|US4802475 *||Jun 22, 1987||Feb 7, 1989||Weshahy Ahmed H A G||Methods and apparatus of applying intra-lesional cryotherapy|
|US4842589 *||Nov 26, 1986||Jun 27, 1989||Sherwood Medical Company||Intercavity catheter|
|US5025797 *||Mar 29, 1989||Jun 25, 1991||Baran Gregory W||Automated biopsy instrument|
|US5047040 *||Feb 16, 1989||Sep 10, 1991||Devices For Vascular Intervention, Inc.||Atherectomy device and method|
|US5125413 *||Apr 17, 1991||Jun 30, 1992||Baran Gregory W||Automated biopsy instrument|
|US5342376 *||May 3, 1993||Aug 30, 1994||Dermagraphics, Inc.||Inserting device for a barbed tissue connector|
|US5417700 *||Mar 25, 1993||May 23, 1995||Thomas D. Egan||Automatic suturing and ligating device|
|US6241747||Oct 18, 1994||Jun 5, 2001||Quill Medical, Inc.||Barbed Bodily tissue connector|
|US6264675 *||Feb 4, 2000||Jul 24, 2001||Gregory R. Brotz||Single suture structure|
|US6364859||May 31, 2000||Apr 2, 2002||Robbins Scientific Corporation||Locking cap for replaceable needle assembly|
|US6478809 *||Jul 23, 2001||Nov 12, 2002||Gregory R. Brotz||Suture and method of use|
|US6599310||Jun 29, 2001||Jul 29, 2003||Quill Medical, Inc.||Suture method|
|US6942684 *||Feb 19, 2002||Sep 13, 2005||Bonutti Ip, Llc||Method and apparatus for positioning an anchor member|
|US7056331||Sep 30, 2002||Jun 6, 2006||Quill Medical, Inc.||Suture method|
|US7225512||Aug 29, 2002||Jun 5, 2007||Quill Medical, Inc.||Method of forming barbs on a suture and apparatus for performing same|
|US7226468||Apr 21, 2003||Jun 5, 2007||Quill Medical, Inc.||Barbed bodily tissue connector|
|US7624487||May 13, 2003||Dec 1, 2009||Quill Medical, Inc.||Apparatus and method for forming barbs on a suture|
|US7758614||Apr 5, 2002||Jul 20, 2010||Tornier, Inc.||Coupling member for knotless sutures and ligatures|
|US7806908||Jan 2, 2008||Oct 5, 2010||Quill Medical, Inc.||Barbed tissue connector|
|US7857827||Apr 14, 2006||Dec 28, 2010||Ethicon Endo-Surgery, Inc.||Endoscopic device|
|US7857829||May 11, 2007||Dec 28, 2010||Quill Medical, Inc.||Suture method|
|US7913365||Mar 27, 2007||Mar 29, 2011||Quill Medical, Inc.||Method of forming barbs on a suture and apparatus for performing same|
|US7996967||Aug 4, 2010||Aug 16, 2011||Quill Medical, Inc.||System for variable-angle cutting of a suture to create tissue retainers of a desired shape and size|
|US7996968||Aug 4, 2010||Aug 16, 2011||Quill Medical, Inc.||Automated method for cutting tissue retainers on a suture|
|US7998167||Apr 14, 2006||Aug 16, 2011||Ethicon Endo-Surgery, Inc.||End effector and method of manufacture|
|US8011072||Aug 4, 2010||Sep 6, 2011||Quill Medical, Inc.||Method for variable-angle cutting of a suture to create tissue retainers of a desired shape and size|
|US8015678||Aug 4, 2010||Sep 13, 2011||Quill Medical, Inc.||Method for cutting a suture to create tissue retainers of a desired shape and size|
|US8020263||Aug 4, 2010||Sep 20, 2011||Quill Medical, Inc.||Automated system for cutting tissue retainers on a suture|
|US8025664||Jul 31, 2007||Sep 27, 2011||Innovative Spine, Llc||System and method for providing surgical access to a spine|
|US8028387||Aug 4, 2010||Oct 4, 2011||Quill Medical, Inc.||System for supporting and cutting suture thread to create tissue retainers thereon|
|US8028388||Aug 4, 2010||Oct 4, 2011||Quill Medical, Inc.||System for cutting a suture to create tissue retainers of a desired shape and size|
|US8032996||May 13, 2004||Oct 11, 2011||Quill Medical, Inc.||Apparatus for forming barbs on a suture|
|US8034070||Feb 24, 2006||Oct 11, 2011||Yale University||Varicose vein dissector and removal apparatus|
|US8057481||Jul 31, 2007||Nov 15, 2011||Innovative Spine, Llc||System and method for providing surgical access to a spine|
|US8083770||May 13, 2008||Dec 27, 2011||Quill Medical, Inc.||Suture anchor and method|
|US8118834||Dec 19, 2008||Feb 21, 2012||Angiotech Pharmaceuticals, Inc.||Composite self-retaining sutures and method|
|US8216273||Feb 25, 2009||Jul 10, 2012||Ethicon, Inc.||Self-retainers with supporting structures on a suture|
|US8246652||Aug 4, 2010||Aug 21, 2012||Ethicon, Inc.||Suture with a pointed end and an anchor end and with equally spaced yieldable tissue grasping barbs located at successive axial locations|
|US8313500||Apr 14, 2006||Nov 20, 2012||Ethicon Endo-Surgery, Inc.||Endoscopic device|
|US8496657||Aug 29, 2008||Jul 30, 2013||P Tech, Llc.||Methods for utilizing vibratory energy to weld, stake and/or remove implants|
|US8597299||Nov 2, 2007||Dec 3, 2013||Innovative Spine, Llc||Instrumentation and method for providing surgical access to a spine|
|US8608767||Jul 21, 2011||Dec 17, 2013||Yale University||Varicose vein dissector and removal apparatus|
|US8615856||Jan 30, 2009||Dec 31, 2013||Ethicon, Inc.||Apparatus and method for forming self-retaining sutures|
|US8617185||Feb 13, 2008||Dec 31, 2013||P Tech, Llc.||Fixation device|
|US8632550||Sep 27, 2011||Jan 21, 2014||Innovative Spine LLC.||System and method for providing surgical access to a spine|
|US8641732||Feb 25, 2009||Feb 4, 2014||Ethicon, Inc.||Self-retaining suture with variable dimension filament and method|
|US8652170||Aug 4, 2010||Feb 18, 2014||Ethicon, Inc.||Double ended barbed suture with an intermediate body|
|US8679158||Aug 4, 2010||Mar 25, 2014||Ethicon, Inc.||Multiple suture thread configuration with an intermediate connector|
|US8690914||Aug 4, 2010||Apr 8, 2014||Ethicon, Inc.||Suture with an intermediate barbed body|
|US8721664||Mar 12, 2013||May 13, 2014||Ethicon, Inc.||Suture methods and devices|
|US8721681||Jun 30, 2009||May 13, 2014||Ethicon, Inc.||Barbed suture in combination with surgical needle|
|US8734485||Aug 4, 2010||May 27, 2014||Ethicon, Inc.||Sutures with barbs that overlap and cover projections|
|US8734486||Aug 4, 2010||May 27, 2014||Ethicon, Inc.||Multiple suture thread configuration with an intermediate connector|
|US8740853||Apr 14, 2006||Jun 3, 2014||Ethicon Endo-Surgery, Inc.||Endoscopic device and method of packaging|
|US8747437||Aug 4, 2010||Jun 10, 2014||Ethicon, Inc.||Continuous stitch wound closure utilizing one-way suture|
|US8747439||Jul 10, 2006||Jun 10, 2014||P Tech, Llc||Method of using ultrasonic vibration to secure body tissue with fastening element|
|US8764776||Aug 4, 2010||Jul 1, 2014||Ethicon, Inc.||Anastomosis method using self-retaining sutures|
|US8764796||Feb 10, 2006||Jul 1, 2014||Ethicon, Inc.||Suture method|
|US8771313||Dec 19, 2008||Jul 8, 2014||Ethicon, Inc.||Self-retaining sutures with heat-contact mediated retainers|
|US8777987||Sep 26, 2008||Jul 15, 2014||Ethicon, Inc.||Self-retaining sutures including tissue retainers having improved strength|
|US8777988||Aug 4, 2010||Jul 15, 2014||Ethicon, Inc.||Methods for using self-retaining sutures in endoscopic procedures|
|US8777989||Aug 4, 2010||Jul 15, 2014||Ethicon, Inc.||Subcutaneous sinusoidal wound closure utilizing one-way suture|
|US8793863||Apr 11, 2008||Aug 5, 2014||Ethicon, Inc.||Method and apparatus for forming retainers on a suture|
|US8795332||Sep 30, 2002||Aug 5, 2014||Ethicon, Inc.||Barbed sutures|
|US8808329||Apr 3, 2012||Aug 19, 2014||Bonutti Skeletal Innovations Llc||Apparatus and method for securing a portion of a body|
|US8814902||Jul 31, 2006||Aug 26, 2014||Bonutti Skeletal Innovations Llc||Method of securing body tissue|
|US8821540||Aug 4, 2010||Sep 2, 2014||Ethicon, Inc.||Self-retaining sutures having effective holding strength and tensile strength|
|US8840621||Jan 22, 2009||Sep 23, 2014||Innovative Spine, Inc.||Spinal access systems and methods|
|US8845687||Sep 17, 2013||Sep 30, 2014||Bonutti Skeletal Innovations Llc||Anchor for securing a suture|
|US8845699||Mar 6, 2012||Sep 30, 2014||Bonutti Skeletal Innovations Llc||Method of securing tissue|
|US8852232||Aug 4, 2010||Oct 7, 2014||Ethicon, Inc.||Self-retaining sutures having effective holding strength and tensile strength|
|US8875607||Jan 30, 2009||Nov 4, 2014||Ethicon, Inc.||Apparatus and method for forming self-retaining sutures|
|US8876865||Apr 14, 2009||Nov 4, 2014||Ethicon, Inc.||Self-retaining sutures with bi-directional retainers or uni-directional retainers|
|US8882715 *||Jun 28, 2007||Nov 11, 2014||Carlos Jaramillo||Catheterization device and method|
|US8915943||Apr 3, 2008||Dec 23, 2014||Ethicon, Inc.||Self-retaining systems for surgical procedures|
|US8916077||Dec 19, 2008||Dec 23, 2014||Ethicon, Inc.||Self-retaining sutures with retainers formed from molten material|
|US8926659||Dec 20, 2010||Jan 6, 2015||Ethicon, Inc.||Barbed suture created having barbs defined by variable-angle cut|
|US8932328||Nov 3, 2009||Jan 13, 2015||Ethicon, Inc.||Length of self-retaining suture and method and device for using the same|
|US8961560||Dec 16, 2010||Feb 24, 2015||Ethicon, Inc.||Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods|
|US9044225||Jan 12, 2012||Jun 2, 2015||Ethicon, Inc.||Composite self-retaining sutures and method|
|US9060767||Mar 2, 2009||Jun 23, 2015||P Tech, Llc||Tissue fastener and methods for using same|
|US9067362||Oct 31, 2007||Jun 30, 2015||P Tech, Llc||Method of using ultrasonic vibration to secure body tissue with fastening element|
|US9089323||Feb 21, 2006||Jul 28, 2015||P Tech, Llc||Device and method for securing body tissue|
|US9125647||Feb 20, 2009||Sep 8, 2015||Ethicon, Inc.||Method and apparatus for elevating retainers on self-retaining sutures|
|US9138222||Feb 17, 2004||Sep 22, 2015||P Tech, Llc||Method and device for securing body tissue|
|US9149281||Jun 7, 2013||Oct 6, 2015||P Tech, Llc||Robotic system for engaging a fastener with body tissue|
|US9155544||Mar 20, 2002||Oct 13, 2015||P Tech, Llc||Robotic systems and methods|
|US9173647||Feb 21, 2006||Nov 3, 2015||P Tech, Llc||Tissue fixation system|
|US9173650||May 31, 2011||Nov 3, 2015||P Tech, Llc||Methods and devices for trauma welding|
|US9192395||May 7, 2013||Nov 24, 2015||P Tech, Llc||Robotic fastening system|
|US9226828||Sep 20, 2013||Jan 5, 2016||P Tech, Llc||Devices and methods for stabilizing tissue and implants|
|US9248580||Dec 22, 2011||Feb 2, 2016||Ethicon, Inc.||Barb configurations for barbed sutures|
|US9271741||Aug 8, 2013||Mar 1, 2016||P Tech, Llc||Robotic ultrasonic energy system|
|US9271766||Nov 11, 2013||Mar 1, 2016||P Tech, Llc||Devices and methods for stabilizing tissue and implants|
|US9271779||Aug 13, 2013||Mar 1, 2016||P Tech, Llc||Methods of using a robotic spine system|
|US9402668||Dec 4, 2013||Aug 2, 2016||P Tech, Llc||Tissue fixation system and method|
|US9421005||Feb 6, 2007||Aug 23, 2016||P Tech, Llc||Methods and devices for intracorporeal bonding of implants with thermal energy|
|US9439642||Feb 24, 2010||Sep 13, 2016||P Tech, Llc||Methods and devices for utilizing bondable materials|
|US9463012||Oct 5, 2005||Oct 11, 2016||P Tech, Llc||Apparatus for guiding and positioning an implant|
|US9486227||Jul 25, 2013||Nov 8, 2016||P Tech, Llc||Robotic retractor system|
|US9498893||Jun 18, 2014||Nov 22, 2016||Ethicon, Inc.||Self-retaining sutures including tissue retainers having improved strength|
|US20020087189 *||Feb 19, 2002||Jul 4, 2002||Bonutti Peter M.||Method and apparatus for positioning a suture anchor|
|US20040030354 *||Aug 9, 2002||Feb 12, 2004||Leung Jeffrey C.||Suture anchor and method|
|US20040087956 *||Oct 22, 2003||May 6, 2004||Synthes (U.S.A)||Tools and methods for creating cavities in bone|
|US20040093028 *||Apr 21, 2003||May 13, 2004||Ruff Gregory L.||Barbed bodily tissue connector|
|US20040210245 *||Jul 25, 2003||Oct 21, 2004||John Erickson||Bendable needle with removable stylet|
|US20040237736 *||Aug 29, 2002||Dec 2, 2004||Genova Perry A.||Method of forming barbs on a suture and apparatus for performing same|
|US20050240227 *||Jun 29, 2005||Oct 27, 2005||Bonutti Peter M||Method and apparatus for positioning an anchor member|
|US20060241695||Jul 10, 2006||Oct 26, 2006||Bonutti Peter M||Method of using ultrasonic vibration to secure body tissue with fastening element|
|US20070187861 *||Mar 27, 2007||Aug 16, 2007||Quill Medical, Inc.||Method of Forming Barbs on a Suture and Apparatus for Performing Same|
|US20070208355 *||May 10, 2007||Sep 6, 2007||Ruff Gregory L||Barbed tissue connector|
|US20070208377 *||May 11, 2007||Sep 6, 2007||Andrew Kaplan||Suture Method|
|US20080027390 *||Jun 28, 2007||Jan 31, 2008||Carlos Jaramillo||Catheterization device and method|
|US20080039845 *||Feb 6, 2007||Feb 14, 2008||Bonutti Peter M||Methods and devices for intracorporeal bonding of implants with thermal energy|
|US20080071304 *||Feb 24, 2006||Mar 20, 2008||Tal Michael G||Varicose Vein Dissector and Removal Apparatus|
|US20080114399 *||Oct 31, 2007||May 15, 2008||Bonutti Peter M||Method of securing body tissue|
|US20080215072 *||Jan 21, 2008||Sep 4, 2008||Graham Kelly||Methods and apparatus for utilization of barbed sutures in human tissue including a method for eliminating or improving blood flow in veins|
|US20080221617 *||Jan 2, 2008||Sep 11, 2008||Quill Medical, Inc.||Barbed tissue connector|
|US20080255563 *||Nov 2, 2007||Oct 16, 2008||Innovative Spine||Instrumentation and method for providing surgical access to a spine|
|US20080281224 *||May 9, 2008||Nov 13, 2008||Johnson Michael E||Biopsy device needle tip|
|US20080306481 *||Jul 31, 2007||Dec 11, 2008||Innovative Spine||System and method for providing surgical access to a spine|
|US20100153335 *||Dec 12, 2008||Jun 17, 2010||Microsoft Corporation||Synchronizing multiple classes with disparate schemas in the same collection|
|US20100298871 *||Aug 4, 2010||Nov 25, 2010||Quill Medical, Inc.||Self-retaining wound closure device including an anchoring loop|
|US20100298876 *||Aug 4, 2010||Nov 25, 2010||Quill Medical, Inc.||Self-retaining sutures having effective holding strength and tensile strength|
|USRE30966 *||Dec 8, 1980||Jun 15, 1982||The Regents Of The University Of California||Wick catheter pressure sensing probe and method of use|
|USRE45426||Jul 31, 2001||Mar 17, 2015||Ethicon, Inc.||Surgical methods using one-way suture|
|WO1999065545A1 *||Jun 15, 1999||Dec 23, 1999||Robbins Scientific Corporation||Syringe with various needle assemblies|
|WO2006093787A3 *||Feb 24, 2006||Apr 16, 2009||Michael G Tal||Varicose vein dissector and removal apparatus|
|U.S. Classification||600/567, 606/187, 606/117|
|International Classification||A61B10/02, A61B10/00|