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Publication numberUS3624224 A
Publication typeGrant
Publication dateNov 30, 1971
Filing dateDec 22, 1969
Priority dateDec 22, 1969
Also published asCA949451A1, DE2031889A1, US3730960
Publication numberUS 3624224 A, US 3624224A, US-A-3624224, US3624224 A, US3624224A
InventorsLing Wei, Robert Marchisotto
Original AssigneeSchering Corp
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Novel first aid products
US 3624224 A
Abstract
Disclosed herein are novel antiseptic compositions comprising an aqueous solution of a quaternary ammonium compound, a local anesthetic and a polyoxyethylene-polyoxypropylene block polymer. They are most advantageously supplied as impregnants of a hermetically sealed pad.
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Description  (OCR text may contain errors)

United States Patent Inventors Ling Wei Watcbung; Robert Marchisotto, East Brunswick, both of NJ. Appl. No. 887,355 Filed Dec. 22, 1969 Patented Nov. 30, 1971 Assignee Scherlng Corporation Bloomfield, NJ.

NOVEL FIRST AID PRQDU TS 8 Claims, No Drawings US. Cl 424/28, 15/506, 128/156, 128/260, 206/57, 206/63.2,

424/329 A61! 13/00, A611 15/00 Field of Search 424/25, 27, 28, 78, 310, 329; 15/506; 252/106; 206/57, 63.2;

Int.

[56] References Cited UNITED STATES PATENTS 1,353,954 9/1920 Henry... 206/57 2,379,657 7/1945 Ryberg 206/63.2 2,689,814 9/1954 Nicholls 424/195 2,702,780 2/1955 Lerner 424/25 X 2,801,201 7/1957 Kipnis 424/310 X 2,921,885 1/1960 Bouchal 424/54 2,999,265 9/1961 Duane et al.. 15/506 3,138,533 6/1964 Heim 424/25 3,264,188 8/1966 Gresham 424/28 3,283,357 11/1966 Decker et a1. 15/506 3,539,520 11/1970 Cantor et a1 252/106 Primary Examiner-Shep K. Rose Anomeys Stephen B. Coan and Bruce M. Eisen ABSTRACT: Disclosed herein is a portable disposable first aid FIRST AID PRODUCTS This invention relates to novel compositions of matter and to an article incorporating these compositions which uniquely fully exploits all their beneficial properties.

These novel compositions can be used to treat minor skin wounds, abrasions, burns, and similar first aid problems. They fight infection, relieve pain on contact and generally soothe the injured area. Furthermore, this antiseptic action is effected without a stinging sensation, thus rendering these compositions especially valuable for treating children and pets who are often reluctant to receive commonly used first aid treatments because of their stinging effect. Moreover, shortly after application, these compositions air-dry and deposit an invisible film which prolongs the activity and aids in protecting the injured area from further immediate contamination. These novel compositions broadly comprise aqueous solutions of a germicidal quaternary ammonium compound, a local anesthetic, and a polyoxyethylene-polyoxypropylene block polymer.

Germicidal quaternary ammonium compounds are wellknown in the art. They are generally used in the form of their halides and preferably as chlorides. Preferred quaternary ammonium compound for use in the compositions of this invention are the alkylarylether dimethylbenzylammonium chlorides, an example of which is 2-[2-(p-octylcresoxy)ethoxy]ethyl dimethylbenzylammonium chloride, available under the name of methylbenzethonium chloride or l-lyamine X and the corresponding p-octylphenoxy compound available as benzethonium chloride or Hyamine 1622, and the alkyldimethylbenzyl ammonium chlorides available under the name benzalkonium chloride. Other suitable germicidal quaternary ammonium compounds are alkyltrimethyl ammonium chloride, such as cetyltrimethylammonium chloride available under the trade name Cetab; alkyldimethylethylammonium halide such as alkenyldimethylethylammonium bromide known under the trade name Onyxide; alkylpyridinium chloride, such as cetylpyridinium chloride; alkylimidazolinium chloride such as alkylhydroxyethylimidazolinium chloride known as Alrosept MB; alkyldimethyldichlorobenzylammonium chloride such as alkyldimethyl-3,4-dichloro benzylammonium chloride known as Tetrosan; acylcolaminoformylmethyl pyridinium chloride available under the name of Emulsept; and alkarylmethylpyridinium chloride such as polyalkulnapthalene methylpyridinium chloride available under the trade name Emcol. In the foregoing compounds the term alkyl" is understood to encompass C l-l to C I-l radicals including mixtures within this range, this being the range in which quaternary ammonium compounds are considered to have good germicidal activity.

Similarly, local anesthetics are a well-known class of materials. The preferred subclass of local anesthetics for use in a composition of this invention are those amino-substituted phenyl esters and amides distinguishable by having a generic name ending in the syllable caine" This class of local anesthetic compounds will be referred to hereinafter as caine-type. Exemplary of these are lidocaine, tetracaine, benzocaine, procaine, cocaine, mepivacaine and bupivacaine. These can be used as the free base or in a form of their pharmaceutically acceptable acid addition salts, particularly as the hydrochloride. Preferred local anesthetics for use in compositions of this invention are tetracaine and lidocaine. Other local anesthetics which are not of the caine-type" can also be used, for example, benzyl alcohol.

The p0lyoxyethylene-polyoxypropylene block polymers to be used in the composition of this invention are also well known in the art and may be represented by the structural formula:

2 )n( 3 6 )I|( 2 -I )r wherein the (C H O) represents the polyoxypropylene hydrophobic base component and the HO(C H ,O),, and (C H,O)H represent the polyoxyethylene hydrophilic constituents. The polyoxyethylene portion of the polymer may vary from as little as l0 percent to as high as 90 percent. The higher the polyoxyethylene percentage, the more water-soluble becomes the total molecule or polymer. The substantially water-soluble polymers in the molecular weight range of between about 5 and about 1 L000 are preferable. These materials are readily available under the trade name Pluronic polyols. A preferred material of this class for use in the compositions of this invention is available under the trade name of Pluronic F68 and has an average molecular weight of about 8350, although it may vary in range between about 6000 and 9000. in this material a and c in the above formula can, for example, each be 72 and b can be 26.

Both the antimicrobial quaternary ammonium compounds and the local anesthetics should be present in the aqueous composition of this invention in a range of 0.1 to 2 percent by weight. The polyoxyethylene-polyoxypropylene block polymers should be present in the amount of 2 to l5 percent by weight of the total composition and preferably 3 to 7 percent. The bulk of the composition is of course water.

The aqueous compositions of this invention can optionally contain, in addition to the above ingredients, other materials to maximize effectiveness.

Nonionic polyethenoxy surface active agents such as the well-known polyethenoxy mono-ethers, polyethenoxy monoesters and polyethenoxy mono-amides are advantageously included in the composition of this invention, preferably in an amount of 0.2 to 3 percent by weight of the composition. These nonionic surface active agents provide detergent action to a much greater extent than the free polyoxyethylenepolyoxypropylene block polymer polyols. Such compounds are well known in the art. The preferred class of materials of this type for use in this invention are the polyethenoxy monoethers of alkylphenols as exemplified by polyethenoxy monoisooctylphenylether, available under the trade name Triton X-100. Other suitable nonionic surface active agents are polyoxyethylenesorbitan monooleate, and the corresponding mono-stearate.

Desirably, the composition of this invention also included a humectant such as propylene glycol, glycerine, sorbitol, diethylene glycol or polyethylene glycol. ln addition to their humectant effect, these materials also serve in aiding dissolution or emulsion of the composition of this invention. These materials are desirably employed within the range of about 1 to 10 percent.

A chelating agent such as ethylenediamine tetraacetic acid (EDTA) can optionally be added to enhance the antibacterial activity of these compositions.

A minor amount (e.g. 3 percent) of isopropanol can be added to impart a medicinal odor." Similarly, a small amount (e.g., 0.5 percent) of menthol provides a soothing cool feeling." Calming an injured child or other patient is a desirable part of first aid treatment.

Auxiliary medicaments may be incorporated into the compositions of this invention to broaden the scope of treatment, as for example, the inclusion of a minor amount of chlorothymol to impart fungicidal properties.

The compositions of this invention can be applied to the injured area in numerous ways. They can be directly applied from a squeeze bottle or dropper, for example, or sprayed on employing an aerosol canister containing a conventional propellant such as the Freons. Alternatively, a swab can be introduced into a container of the formulation and saturated therewith and applied to the injured area. Similarly, the solutions can be applied by means of a handkerchief or other extraneous cloth or tissue. Each of these methods has disadvantages, however, with regard to convenience, hygiene and/or effectiveness.

As a highly preferred embodiment of this invention, we have found that the maximum benefit of the compositions of this invention can be realized in the embodiment of a hermetically sealed packet containing a pad impregnated with these compositions. The pad should be an absorptive sheet preferably made of nonwoven cellulosic material. Nonwoven rayon has been found to be particularly good for this purpose. The packet should be impervious to liquid or vapor and its interior should be inert to the composition of this invention. Such packets are well known in the art and preferably comprises an outer surface of a metal foil such as aluminum whose inner surface is lined with a thermoplastic film such as polyethylene, polyvinyl resin or cellulose acetate as described, for example, in U.S. Pat. No. 3,057,467 A laminate having an intermediate layer of paper is an advantageous variation. This sealed packet protects both the composition and the applicator against'contamination occurring after manufacture and before application to the wounded area.

The invention in this preferred embodiment furthermore provides a sanitary means to cleanse the wounded area thoroughly of dirt and other particles. Thus, it aids in preventing further infection by removal of superficial organisms that have not yet infected the wound, and by prophylaxis of the surrounding area, while at the same time fighting infection by any organisms already in the wound. Use of this pad also permits the application of a thin uniform coating of the composition, thereby minimizing the time necessary for the skin to dry and the film to form. In this embodiment it is preferred that the compositions additionally contain a nonionic polyethenoxy surface active agent as described above to further aid in the cleansing operation.

This preferred embodiment provides an ideal means to have the compositions of this invention readily available at the time the injury is sustained since it can be carried in the pocket, handbag, as well as stored on vehicles or at home or work. The entire packet is inexpensive enough to be disposed of after a single use. Moreover, the open foil packet provides a hygienic place to temporarily store the used pad until suitable disposal facilities become available.

The following example illustrates a preferred embodiment of this invention.

EXAMPLE A piece of nonwoven rayon pad measuring 3 inches X 3%inches is folded longitudinally and transversely and is inserted into a pouch formed by two sheets of a laminate of aluminum foil and paper, coated (on the paper'side) with polyethylene. Two milliliters of a formulation consisting of:

methylbenzethonium chloride 0.5% telracnine hydrochloride 0.6% polyoxyelhylene-polyoxypropylene 5.0%

(Pluronic F68) polyethenoxy alkylaryl ether 2.0%

(Triton X I) propylene glycol 3.0% isopropyl alcohol 3.0% methanol 0.11

purified water 85.8%

are injected into the folds of the pad and the aluminum laminate is then heat sealed on the open fourth side to complete the packet.

The pad could alternatively be folded in a zigzag or accordian-pleating" fold. Numerous other variations of the above-described nonstinging products and processes that within the spirit of this invention will become apparent to one skilled in the art.

We claim:

1. An absorptive nonwoven cellulosic sheet of single use disposable pad material impregnated with a nonstinging antiseptic composition which air-dries and forms a protective and activity-prolonging film coating, said composition consisting essentially of an aqueous solution of effective amounts within the range of 0.1-2 percent by weight of each of a germicidal quaternary ammonium halide and a local anesthetic compound, and 2-150 by weight of a water soluble polyoxyethylene-polyoxypropylene block polymer and 0.2-3 percent by weight of a nonionic surface active agent selected from the class consisting of polyethenoxy ethers, polyethenoxy esters and polyethenoxy amides, said disposable pad being of suitabl small dimensions to be folded and filled into a hermetica ly sealed packet that can be earned in the pocket or handbag.

2. A pad material according to claim 1 wherein said local anesthetic compound is of the "caine" type.

3. A pad material according to claim 1 wherein said block polymer has an average molecular weight between about 6000 and 9000.

4. A pad material according to claim 1 wherein said local anesthetic is selected from the group consisting of tetracaine and lidocaine.

5. A pad material according to claim 4 wherein said nonionic surface active agent is a polyethenoxy mono-alkylaryl ether.

6. A pad material according to claim I wherein said cellulosic sheet material is rayon.

7. A method of painlessly forming a thin invisible uniform protective and activity-prolonging film coating on a skin wound comprising applying to said would by means of an absorptive nonwoven cellulosic sheet of single use disposable pad material impregnated in accordance with claim 14, said composition comprising a germicidal quaternary ammonium halide, said local anesthetic, said oxyethylene-oxypropylene block polymer and said nonionic surface active agent.

8. A method according to claim 7 wherein said cellulosic sheet material is rayon.

UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 5, 62%, 22 Dated November 50, 19?].

Inventor) Ling Wei and Robert Marchisotto It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

F. Column 1, lines ML and 1L5, "polyalkulnapthalene" should read polyalklynapthalene Column 1, line 72, (C H O)H" should read (C H O) H Column 3, lines 2 and 5 "comprises" should read comprise Column 5, line +8, "methamof should read menthol Column line 18,

"2-150" should read 2l5/ Column line +1, "said would" should read said wound Signed and sealed this 13th day of June 1972.

(SEAL) Attest:

EDWARD M.FLETCHER, JR. ROBERT GOTTSCHALK Attesting Officer Commissioner of Patents

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US1353954 *May 23, 1919Sep 28, 1920 Combined towel and antiseptic pad
US2379657 *Aug 22, 1942Jul 3, 1945Ryco Lab IncPackage
US2689814 *Apr 5, 1951Sep 21, 1954Miles LabAnesthetic and fungicidal chlorothymol composition and solution thereof
US2702780 *Oct 10, 1950Feb 22, 1955Jack I Le VantMeasuring dispensing sheet for germicides and process of forming same
US2801201 *Apr 9, 1953Jul 30, 1957Lincoln Lab IncBurn treatment filling for pressure packaged dispenser
US2921885 *Nov 25, 1955Jan 19, 1960Colgate Palmolive CoAntibacterial composition
US2999265 *Sep 23, 1957Sep 12, 1961Dorothy B TarnoffSaturated pad for cleansing and deodorizing
US3138533 *May 27, 1958Jun 23, 1964Heim Leo JSanitary tissues
US3264188 *Jan 16, 1963Aug 2, 1966Kimberly Clark CoSanitary impregnated skin wiper
US3283357 *Oct 6, 1964Nov 8, 1966Michigan Tool CoDisinfecting cleansing pad
US3539520 *Jul 12, 1967Nov 10, 1970West Laboratories IncCompositions comprising quaternary ammonium germicides and nonionic surfactants
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3814095 *Mar 24, 1972Jun 4, 1974H LubensOcclusively applied anesthetic patch
US3902559 *Jun 28, 1973Sep 2, 1975Water Jel Int Pty LtdFire fighting appliances
US4259103 *May 14, 1979Mar 31, 1981Dow Corning CorporationAdsorption on substrate by ion exchange
US4307143 *Jul 21, 1980Dec 22, 1981Kimberly-Clark CorporationAbsorbent wiper of polypropylene
US4321277 *Feb 4, 1980Mar 23, 1982Research Lab Products, Inc.Germicidal use of compositions containing certain quaternary ammonium compounds
US4340043 *Nov 15, 1979Jul 20, 1982Smith & Nephew Research Ltd.Adhesive-coated sheet material incorporating anti-bacterial substances
US4460369 *Dec 21, 1981Jul 17, 1984Smith & Nephew Research Ltd.Adhesive-coated sheet material incorporating anti-bacterial substances
US4464293 *Apr 12, 1982Aug 7, 1984Dobrin Robert JLiquid cleaner-disinfectant composition for use in wiping down dental operatories
US4615937 *Sep 5, 1985Oct 7, 1986The James River CorporationAntimicrobially active, non-woven web used in a wet wiper
US4692374 *Jul 16, 1986Sep 8, 1987James River CorporationBinding antimicrobial agent in unbonded fibers; drying, curing, bonding
US4721511 *Oct 5, 1984Jan 26, 1988W. R. Grace & Co.Leach resistant antimicrobial fabric
US4732797 *Feb 27, 1987Mar 22, 1988James River CorporationMixture of citric and sorbic acid
US4737405 *Oct 31, 1986Apr 12, 1988James River CorporationWet wiper from cellulose fibers; leachable, nontoxic
US4740398 *Sep 30, 1985Apr 26, 1988James River CorporationBinder catalyst for an antimicrobially active, non-woven web
US4746509 *Feb 3, 1987May 24, 1988Rhone-Poulenc SanteDispersion in film-forming polymer
US4781974 *Mar 9, 1987Nov 1, 1988James River CorporationBonded fibers and microbiocide
US4834076 *Apr 15, 1986May 30, 1989Millet Jean MDevice for treating the external human epithelium, process for its manufacture and process for using such a device
US4920158 *Aug 22, 1988Apr 24, 1990Medipro Sciences LimitedHydrogel-forming wound dressing or skin coating material
US5013769 *Feb 6, 1990May 7, 1991Medipro Sciences LimitedMethod of making a hydrogel-forming wound dressing or skin coating material
US5286538 *Aug 3, 1992Feb 15, 1994Leonard PearlsteinDisposable container for moist paper towels the same
US5409747 *Nov 19, 1993Apr 25, 1995Leonard PearlsteinPaperboard having barrier polymeric coating resistant to water, abrasion and contamination; biodegradable
US5458933 *Dec 17, 1993Oct 17, 1995Leonard PearlsteinCompostable packaging for containment of liquids
US5512333 *Apr 6, 1994Apr 30, 1996Icd IndustriesTreating interior surfaces of paperboard with corona discharge, coating with biodegradable polymer, coating exterior surface with polymer containing photodegradable polyolefin
US5540962 *Apr 6, 1994Jul 30, 1996Leonard PearlsteinBiodegradable
US5895504 *Jul 9, 1997Apr 20, 1999S. C. Johnson & Son, Inc.Methods for using a fabric wipe
US6364862 *Sep 17, 1999Apr 2, 2002Daniel BonillaSingle pad for providing both an anesthetic and an antiseptic for an injection site
US6702925Dec 21, 2001Mar 9, 2004Vibre-Tech LlcTransferring vibrational force to wire of papermaking machine in order to re-align fibers of the web forming on the wire or to clean press section felts
US6986897Aug 4, 2000Jan 17, 2006Johnson & Johnson Consumer Companies, Inc.Alcohol-free anti-bacterial wipes
US7101462Aug 22, 2003Sep 5, 2006Vibre-Tech, LlcMethod and apparatus for forming a paper or tissue web
US7169262Feb 2, 2004Jan 30, 2007Vibre-Tech LlcMethod and apparatus for forming a paper or tissue web
US7947086May 31, 2006May 24, 2011The Procter & Gamble CompanyMethod for cleaning household fabric-based surface with premoistened wipe
USRE31885 *Dec 20, 1983May 14, 1985Kimberly-Clark CorporationMicrofiber oil and water wipe
EP0954312A1 *Aug 12, 1997Nov 10, 1999Bruce MillerTopical composition for burn healing
EP1744767A2 *Apr 20, 2005Jan 24, 2007The University of ChicagoTherapeutic delivery system comprising a high molecular weight peg-like compound
WO2000050004A2 *Feb 23, 2000Aug 31, 2000Adelman Thomas GSurgical anesthesia delivery system
WO2004019682A1 *Aug 28, 2002Mar 11, 2004Torres Luis BuilPharmaceutical composition for the treatment of viral, fungal and bacterial infections and applications of same
Classifications
U.S. Classification424/443, 514/626, 15/104.93, 514/535, 602/904, 510/438, 604/290, 510/131, 206/438, 510/384, 206/570, 206/812, 206/205, 510/442, 206/828
International ClassificationA61L15/26, A61K31/77, A61L15/46
Cooperative ClassificationA61L2300/802, A61L15/46, A61L2300/45, Y10S602/904, A61L2300/404, Y10S206/828, A61L15/26, A61K31/77, A61L2300/402, A61L2300/208, Y10S206/812
European ClassificationA61K31/77, A61L15/26, A61L15/46