|Publication number||US3624224 A|
|Publication date||Nov 30, 1971|
|Filing date||Dec 22, 1969|
|Priority date||Dec 22, 1969|
|Also published as||CA949451A, CA949451A1, DE2031889A1, US3730960|
|Publication number||US 3624224 A, US 3624224A, US-A-3624224, US3624224 A, US3624224A|
|Inventors||Ling Wei, Robert Marchisotto|
|Original Assignee||Schering Corp|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (11), Referenced by (49), Classifications (32)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent Inventors Ling Wei Watcbung; Robert Marchisotto, East Brunswick, both of NJ. Appl. No. 887,355 Filed Dec. 22, 1969 Patented Nov. 30, 1971 Assignee Scherlng Corporation Bloomfield, NJ.
NOVEL FIRST AID PRQDU TS 8 Claims, No Drawings US. Cl 424/28, 15/506, 128/156, 128/260, 206/57, 206/63.2,
424/329 A61! 13/00, A611 15/00 Field of Search 424/25, 27, 28, 78, 310, 329; 15/506; 252/106; 206/57, 63.2;
 References Cited UNITED STATES PATENTS 1,353,954 9/1920 Henry... 206/57 2,379,657 7/1945 Ryberg 206/63.2 2,689,814 9/1954 Nicholls 424/195 2,702,780 2/1955 Lerner 424/25 X 2,801,201 7/1957 Kipnis 424/310 X 2,921,885 1/1960 Bouchal 424/54 2,999,265 9/1961 Duane et al.. 15/506 3,138,533 6/1964 Heim 424/25 3,264,188 8/1966 Gresham 424/28 3,283,357 11/1966 Decker et a1. 15/506 3,539,520 11/1970 Cantor et a1 252/106 Primary Examiner-Shep K. Rose Anomeys Stephen B. Coan and Bruce M. Eisen ABSTRACT: Disclosed herein is a portable disposable first aid FIRST AID PRODUCTS This invention relates to novel compositions of matter and to an article incorporating these compositions which uniquely fully exploits all their beneficial properties.
These novel compositions can be used to treat minor skin wounds, abrasions, burns, and similar first aid problems. They fight infection, relieve pain on contact and generally soothe the injured area. Furthermore, this antiseptic action is effected without a stinging sensation, thus rendering these compositions especially valuable for treating children and pets who are often reluctant to receive commonly used first aid treatments because of their stinging effect. Moreover, shortly after application, these compositions air-dry and deposit an invisible film which prolongs the activity and aids in protecting the injured area from further immediate contamination. These novel compositions broadly comprise aqueous solutions of a germicidal quaternary ammonium compound, a local anesthetic, and a polyoxyethylene-polyoxypropylene block polymer.
Germicidal quaternary ammonium compounds are wellknown in the art. They are generally used in the form of their halides and preferably as chlorides. Preferred quaternary ammonium compound for use in the compositions of this invention are the alkylarylether dimethylbenzylammonium chlorides, an example of which is 2-[2-(p-octylcresoxy)ethoxy]ethyl dimethylbenzylammonium chloride, available under the name of methylbenzethonium chloride or l-lyamine X and the corresponding p-octylphenoxy compound available as benzethonium chloride or Hyamine 1622, and the alkyldimethylbenzyl ammonium chlorides available under the name benzalkonium chloride. Other suitable germicidal quaternary ammonium compounds are alkyltrimethyl ammonium chloride, such as cetyltrimethylammonium chloride available under the trade name Cetab; alkyldimethylethylammonium halide such as alkenyldimethylethylammonium bromide known under the trade name Onyxide; alkylpyridinium chloride, such as cetylpyridinium chloride; alkylimidazolinium chloride such as alkylhydroxyethylimidazolinium chloride known as Alrosept MB; alkyldimethyldichlorobenzylammonium chloride such as alkyldimethyl-3,4-dichloro benzylammonium chloride known as Tetrosan; acylcolaminoformylmethyl pyridinium chloride available under the name of Emulsept; and alkarylmethylpyridinium chloride such as polyalkulnapthalene methylpyridinium chloride available under the trade name Emcol. In the foregoing compounds the term alkyl" is understood to encompass C l-l to C I-l radicals including mixtures within this range, this being the range in which quaternary ammonium compounds are considered to have good germicidal activity.
Similarly, local anesthetics are a well-known class of materials. The preferred subclass of local anesthetics for use in a composition of this invention are those amino-substituted phenyl esters and amides distinguishable by having a generic name ending in the syllable caine" This class of local anesthetic compounds will be referred to hereinafter as caine-type. Exemplary of these are lidocaine, tetracaine, benzocaine, procaine, cocaine, mepivacaine and bupivacaine. These can be used as the free base or in a form of their pharmaceutically acceptable acid addition salts, particularly as the hydrochloride. Preferred local anesthetics for use in compositions of this invention are tetracaine and lidocaine. Other local anesthetics which are not of the caine-type" can also be used, for example, benzyl alcohol.
The p0lyoxyethylene-polyoxypropylene block polymers to be used in the composition of this invention are also well known in the art and may be represented by the structural formula:
2 )n( 3 6 )I|( 2 -I )r wherein the (C H O) represents the polyoxypropylene hydrophobic base component and the HO(C H ,O),, and (C H,O)H represent the polyoxyethylene hydrophilic constituents. The polyoxyethylene portion of the polymer may vary from as little as l0 percent to as high as 90 percent. The higher the polyoxyethylene percentage, the more water-soluble becomes the total molecule or polymer. The substantially water-soluble polymers in the molecular weight range of between about 5 and about 1 L000 are preferable. These materials are readily available under the trade name Pluronic polyols. A preferred material of this class for use in the compositions of this invention is available under the trade name of Pluronic F68 and has an average molecular weight of about 8350, although it may vary in range between about 6000 and 9000. in this material a and c in the above formula can, for example, each be 72 and b can be 26.
Both the antimicrobial quaternary ammonium compounds and the local anesthetics should be present in the aqueous composition of this invention in a range of 0.1 to 2 percent by weight. The polyoxyethylene-polyoxypropylene block polymers should be present in the amount of 2 to l5 percent by weight of the total composition and preferably 3 to 7 percent. The bulk of the composition is of course water.
The aqueous compositions of this invention can optionally contain, in addition to the above ingredients, other materials to maximize effectiveness.
Nonionic polyethenoxy surface active agents such as the well-known polyethenoxy mono-ethers, polyethenoxy monoesters and polyethenoxy mono-amides are advantageously included in the composition of this invention, preferably in an amount of 0.2 to 3 percent by weight of the composition. These nonionic surface active agents provide detergent action to a much greater extent than the free polyoxyethylenepolyoxypropylene block polymer polyols. Such compounds are well known in the art. The preferred class of materials of this type for use in this invention are the polyethenoxy monoethers of alkylphenols as exemplified by polyethenoxy monoisooctylphenylether, available under the trade name Triton X-100. Other suitable nonionic surface active agents are polyoxyethylenesorbitan monooleate, and the corresponding mono-stearate.
Desirably, the composition of this invention also included a humectant such as propylene glycol, glycerine, sorbitol, diethylene glycol or polyethylene glycol. ln addition to their humectant effect, these materials also serve in aiding dissolution or emulsion of the composition of this invention. These materials are desirably employed within the range of about 1 to 10 percent.
A chelating agent such as ethylenediamine tetraacetic acid (EDTA) can optionally be added to enhance the antibacterial activity of these compositions.
A minor amount (e.g. 3 percent) of isopropanol can be added to impart a medicinal odor." Similarly, a small amount (e.g., 0.5 percent) of menthol provides a soothing cool feeling." Calming an injured child or other patient is a desirable part of first aid treatment.
Auxiliary medicaments may be incorporated into the compositions of this invention to broaden the scope of treatment, as for example, the inclusion of a minor amount of chlorothymol to impart fungicidal properties.
The compositions of this invention can be applied to the injured area in numerous ways. They can be directly applied from a squeeze bottle or dropper, for example, or sprayed on employing an aerosol canister containing a conventional propellant such as the Freons. Alternatively, a swab can be introduced into a container of the formulation and saturated therewith and applied to the injured area. Similarly, the solutions can be applied by means of a handkerchief or other extraneous cloth or tissue. Each of these methods has disadvantages, however, with regard to convenience, hygiene and/or effectiveness.
As a highly preferred embodiment of this invention, we have found that the maximum benefit of the compositions of this invention can be realized in the embodiment of a hermetically sealed packet containing a pad impregnated with these compositions. The pad should be an absorptive sheet preferably made of nonwoven cellulosic material. Nonwoven rayon has been found to be particularly good for this purpose. The packet should be impervious to liquid or vapor and its interior should be inert to the composition of this invention. Such packets are well known in the art and preferably comprises an outer surface of a metal foil such as aluminum whose inner surface is lined with a thermoplastic film such as polyethylene, polyvinyl resin or cellulose acetate as described, for example, in U.S. Pat. No. 3,057,467 A laminate having an intermediate layer of paper is an advantageous variation. This sealed packet protects both the composition and the applicator against'contamination occurring after manufacture and before application to the wounded area.
The invention in this preferred embodiment furthermore provides a sanitary means to cleanse the wounded area thoroughly of dirt and other particles. Thus, it aids in preventing further infection by removal of superficial organisms that have not yet infected the wound, and by prophylaxis of the surrounding area, while at the same time fighting infection by any organisms already in the wound. Use of this pad also permits the application of a thin uniform coating of the composition, thereby minimizing the time necessary for the skin to dry and the film to form. In this embodiment it is preferred that the compositions additionally contain a nonionic polyethenoxy surface active agent as described above to further aid in the cleansing operation.
This preferred embodiment provides an ideal means to have the compositions of this invention readily available at the time the injury is sustained since it can be carried in the pocket, handbag, as well as stored on vehicles or at home or work. The entire packet is inexpensive enough to be disposed of after a single use. Moreover, the open foil packet provides a hygienic place to temporarily store the used pad until suitable disposal facilities become available.
The following example illustrates a preferred embodiment of this invention.
EXAMPLE A piece of nonwoven rayon pad measuring 3 inches X 3%inches is folded longitudinally and transversely and is inserted into a pouch formed by two sheets of a laminate of aluminum foil and paper, coated (on the paper'side) with polyethylene. Two milliliters of a formulation consisting of:
methylbenzethonium chloride 0.5% telracnine hydrochloride 0.6% polyoxyelhylene-polyoxypropylene 5.0%
(Pluronic F68) polyethenoxy alkylaryl ether 2.0%
(Triton X I) propylene glycol 3.0% isopropyl alcohol 3.0% methanol 0.11
purified water 85.8%
are injected into the folds of the pad and the aluminum laminate is then heat sealed on the open fourth side to complete the packet.
The pad could alternatively be folded in a zigzag or accordian-pleating" fold. Numerous other variations of the above-described nonstinging products and processes that within the spirit of this invention will become apparent to one skilled in the art.
1. An absorptive nonwoven cellulosic sheet of single use disposable pad material impregnated with a nonstinging antiseptic composition which air-dries and forms a protective and activity-prolonging film coating, said composition consisting essentially of an aqueous solution of effective amounts within the range of 0.1-2 percent by weight of each of a germicidal quaternary ammonium halide and a local anesthetic compound, and 2-150 by weight of a water soluble polyoxyethylene-polyoxypropylene block polymer and 0.2-3 percent by weight of a nonionic surface active agent selected from the class consisting of polyethenoxy ethers, polyethenoxy esters and polyethenoxy amides, said disposable pad being of suitabl small dimensions to be folded and filled into a hermetica ly sealed packet that can be earned in the pocket or handbag.
2. A pad material according to claim 1 wherein said local anesthetic compound is of the "caine" type.
3. A pad material according to claim 1 wherein said block polymer has an average molecular weight between about 6000 and 9000.
4. A pad material according to claim 1 wherein said local anesthetic is selected from the group consisting of tetracaine and lidocaine.
5. A pad material according to claim 4 wherein said nonionic surface active agent is a polyethenoxy mono-alkylaryl ether.
6. A pad material according to claim I wherein said cellulosic sheet material is rayon.
7. A method of painlessly forming a thin invisible uniform protective and activity-prolonging film coating on a skin wound comprising applying to said would by means of an absorptive nonwoven cellulosic sheet of single use disposable pad material impregnated in accordance with claim 14, said composition comprising a germicidal quaternary ammonium halide, said local anesthetic, said oxyethylene-oxypropylene block polymer and said nonionic surface active agent.
8. A method according to claim 7 wherein said cellulosic sheet material is rayon.
UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 5, 62%, 22 Dated November 50, 19?].
Inventor) Ling Wei and Robert Marchisotto It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:
F. Column 1, lines ML and 1L5, "polyalkulnapthalene" should read polyalklynapthalene Column 1, line 72, (C H O)H" should read (C H O) H Column 3, lines 2 and 5 "comprises" should read comprise Column 5, line +8, "methamof should read menthol Column line 18,
"2-150" should read 2l5/ Column line +1, "said would" should read said wound Signed and sealed this 13th day of June 1972.
EDWARD M.FLETCHER, JR. ROBERT GOTTSCHALK Attesting Officer Commissioner of Patents
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1353954 *||May 23, 1919||Sep 28, 1920||Combined towel and antiseptic pad|
|US2379657 *||Aug 22, 1942||Jul 3, 1945||Ryco Lab Inc||Package|
|US2689814 *||Apr 5, 1951||Sep 21, 1954||Miles Lab||Anesthetic and fungicidal chlorothymol composition and solution thereof|
|US2702780 *||Oct 10, 1950||Feb 22, 1955||Jack I Le Vant||Measuring dispensing sheet for germicides and process of forming same|
|US2801201 *||Apr 9, 1953||Jul 30, 1957||Lincoln Lab Inc||Burn treatment filling for pressure packaged dispenser|
|US2921885 *||Nov 25, 1955||Jan 19, 1960||Colgate Palmolive Co||Antibacterial composition|
|US2999265 *||Sep 23, 1957||Sep 12, 1961||Dorothy B Tarnoff||Saturated pad for cleansing and deodorizing|
|US3138533 *||May 27, 1958||Jun 23, 1964||Heim Leo J||Sanitary tissues|
|US3264188 *||Jan 16, 1963||Aug 2, 1966||Kimberly Clark Co||Sanitary impregnated skin wiper|
|US3283357 *||Oct 6, 1964||Nov 8, 1966||Michigan Tool Co||Disinfecting cleansing pad|
|US3539520 *||Jul 12, 1967||Nov 10, 1970||West Laboratories Inc||Compositions comprising quaternary ammonium germicides and nonionic surfactants|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3814095 *||Mar 24, 1972||Jun 4, 1974||H Lubens||Occlusively applied anesthetic patch|
|US3902559 *||Jun 28, 1973||Sep 2, 1975||Water Jel Int Pty Ltd||Fire fighting appliances|
|US4259103 *||May 14, 1979||Mar 31, 1981||Dow Corning Corporation||Method of reducing the number of microorganisms in a media and a method of preservation|
|US4307143 *||Jul 21, 1980||Dec 22, 1981||Kimberly-Clark Corporation||Microfiber oil and water pipe|
|US4321277 *||Feb 4, 1980||Mar 23, 1982||Research Lab Products, Inc.||Germicidal use of compositions containing certain quaternary ammonium compounds|
|US4340043 *||Nov 15, 1979||Jul 20, 1982||Smith & Nephew Research Ltd.||Adhesive-coated sheet material incorporating anti-bacterial substances|
|US4460369 *||Dec 21, 1981||Jul 17, 1984||Smith & Nephew Research Ltd.||Adhesive-coated sheet material incorporating anti-bacterial substances|
|US4464293 *||Apr 12, 1982||Aug 7, 1984||Dobrin Robert J||Liquid cleaner-disinfectant composition for use in wiping down dental operatories|
|US4615937 *||Sep 5, 1985||Oct 7, 1986||The James River Corporation||Antimicrobially active, non-woven web used in a wet wiper|
|US4692374 *||Jul 16, 1986||Sep 8, 1987||James River Corporation||Antimicrobially active, non-woven web used in a wet wiper|
|US4721511 *||Oct 5, 1984||Jan 26, 1988||W. R. Grace & Co.||Leach resistant antimicrobial fabric|
|US4732797 *||Feb 27, 1987||Mar 22, 1988||James River Corporation||Wet wiper natural acid preservation system|
|US4737405 *||Oct 31, 1986||Apr 12, 1988||James River Corporation||Binder catalyst for an antimicrobially active, non-woven web|
|US4740398 *||Sep 30, 1985||Apr 26, 1988||James River Corporation||Binder catalyst for an antimicrobially active, non-woven web|
|US4746509 *||Feb 3, 1987||May 24, 1988||Rhone-Poulenc Sante||Transdermal medicament|
|US4781974 *||Mar 9, 1987||Nov 1, 1988||James River Corporation||Antimicrobially active wet wiper|
|US4834076 *||Apr 15, 1986||May 30, 1989||Millet Jean M||Device for treating the external human epithelium, process for its manufacture and process for using such a device|
|US4920158 *||Aug 22, 1988||Apr 24, 1990||Medipro Sciences Limited||Hydrogel-forming wound dressing or skin coating material|
|US5013769 *||Feb 6, 1990||May 7, 1991||Medipro Sciences Limited||Method of making a hydrogel-forming wound dressing or skin coating material|
|US5286538 *||Aug 3, 1992||Feb 15, 1994||Leonard Pearlstein||Disposable container for moist paper towels the same|
|US5409747 *||Nov 19, 1993||Apr 25, 1995||Leonard Pearlstein||Disposable container for moist paper towels and a method of making the same|
|US5458933 *||Dec 17, 1993||Oct 17, 1995||Leonard Pearlstein||Compostable packaging for containment of liquids|
|US5512333 *||Apr 6, 1994||Apr 30, 1996||Icd Industries||Method of making and using a degradable package for containment of liquids|
|US5540962 *||Apr 6, 1994||Jul 30, 1996||Leonard Pearlstein||Degradable package for containment of liquids|
|US5895504 *||Jul 9, 1997||Apr 20, 1999||S. C. Johnson & Son, Inc.||Methods for using a fabric wipe|
|US6364862 *||Sep 17, 1999||Apr 2, 2002||Daniel Bonilla||Single pad for providing both an anesthetic and an antiseptic for an injection site|
|US6702925||Dec 21, 2001||Mar 9, 2004||Vibre-Tech Llc||Method and apparatus for forming a paper or tissue web|
|US6986897||Aug 4, 2000||Jan 17, 2006||Johnson & Johnson Consumer Companies, Inc.||Alcohol-free anti-bacterial wipes|
|US7101462||Aug 22, 2003||Sep 5, 2006||Vibre-Tech, Llc||Method and apparatus for forming a paper or tissue web|
|US7169262||Feb 2, 2004||Jan 30, 2007||Vibre-Tech Llc||Method and apparatus for forming a paper or tissue web|
|US7947086||May 31, 2006||May 24, 2011||The Procter & Gamble Company||Method for cleaning household fabric-based surface with premoistened wipe|
|US20030165403 *||Mar 28, 2001||Sep 4, 2003||Marsden James L.||Decontamination of surface exposed to biological warfare agents|
|US20040140077 *||Aug 22, 2003||Jul 22, 2004||Bricco Michael J.||Method and apparatus for forming a paper or tissue web|
|US20040149415 *||Feb 2, 2004||Aug 5, 2004||Vibre-Tech Llc||Method and apparatus for forming a paper or tissue web|
|US20060052269 *||Aug 31, 2005||Mar 9, 2006||Panandiker Rajan K||Premoistened disposable wipe|
|US20060276356 *||May 31, 2006||Dec 7, 2006||Global General||Premoistened wipe|
|US20060277706 *||Apr 11, 2006||Dec 14, 2006||Clark Melissa D||Implement for use with a cleaning sheet|
|US20070037721 *||Aug 31, 2006||Feb 15, 2007||The Procter & Gamble Company||Moistened disposable wipe for controlling allergens|
|US20070068644 *||Aug 22, 2006||Mar 29, 2007||Vibre-Tech, Llc.||Method and apparatus for forming a paper or tissue web|
|US20080206188 *||Apr 20, 2005||Aug 28, 2008||Alverdy John C||Therapeutic Delivery System Comprising a High Molecular Weight Peg-Like Compound|
|US20090088705 *||Oct 2, 2007||Apr 2, 2009||Sirkin Neil||Application system for topically applied compositions|
|USRE31885 *||Dec 20, 1983||May 14, 1985||Kimberly-Clark Corporation||Microfiber oil and water wipe|
|EP0954312A1 *||Aug 12, 1997||Nov 10, 1999||Bruce Miller||Topical composition for burn healing|
|EP0954312A4 *||Aug 12, 1997||Dec 1, 1999||Title not available|
|EP1744767A2 *||Apr 20, 2005||Jan 24, 2007||The University of Chicago||Therapeutic delivery system comprising a high molecular weight peg-like compound|
|EP1744767A4 *||Apr 20, 2005||Aug 13, 2008||Univ Chicago||Therapeutic delivery system comprising a high molecular weight peg-like compound|
|WO2000050004A2 *||Feb 23, 2000||Aug 31, 2000||Ioteck, Inc.||Surgical anesthesia delivery system|
|WO2000050004A3 *||Feb 23, 2000||Sep 7, 2001||Ioteck Inc||Surgical anesthesia delivery system|
|WO2004019682A1 *||Aug 28, 2002||Mar 11, 2004||Torres Luis Buil||Pharmaceutical composition for the treatment of viral, fungal and bacterial infections and applications of same|
|U.S. Classification||424/443, 514/626, 15/104.93, 514/535, 602/904, 510/438, 604/290, 510/131, 206/438, 510/384, 206/570, 206/812, 206/205, 510/442, 206/828|
|International Classification||A61L15/26, A61K31/77, A61L15/46|
|Cooperative Classification||A61L2300/802, A61L15/46, A61L2300/45, Y10S602/904, A61L2300/404, Y10S206/828, A61L15/26, A61K31/77, A61L2300/402, A61L2300/208, Y10S206/812|
|European Classification||A61K31/77, A61L15/26, A61L15/46|