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Publication numberUS3637072 A
Publication typeGrant
Publication dateJan 25, 1972
Filing dateJan 2, 1970
Priority dateJan 9, 1969
Also published asDE2000772A1, DE2000772B2, DE2000772C3, US3696579
Publication numberUS 3637072 A, US 3637072A, US-A-3637072, US3637072 A, US3637072A
InventorsIizuka Noritoshi, Narusawa Shozo
Original AssigneeYurin Tokushu Kogyo Co Ltd
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Device for preserving drugs for injection
US 3637072 A
Abstract
A drug preservation container unit for use in connection with injection. It comprises a vertically elongated casing sealed with a cap and a needle assembly held in an upright position within said casing, said needle assembly containing a freeze-drying processed drug for use in injection and arranged to be connected to a syringe. The unit contains such drug in such a small quantity as to be conveniently dispensed to a small number of persons.
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Description  (OCR text may contain errors)

Unit

tates 1' int hall Narnsawa et al.

DEWMZE FUR PRESENT/ENG DRUGS FUR lINJE CTIIUN Inventors: Shozo Narusawa; Noritoslhi llizulta, both of Tokyo, Japan Yurin 'llolrushu lKogyo (10., lLtcL, Tokyo, Japan Jan. 2, 1970 Assignee:

Filed:

Appl. N0.:

Foreign Application Priority Data Jan. 9, l969 Japan ..44/l840 U.S. Cl .206/632 M, 206/43, 206/47 A lint. 'Cl. ..ll365d 65/54, A611 5/32 Field of Search ..206/43, 47 A, 63.2 R, 17.5

[56] References (Jilted UNITED STATES PATENTS 3,337,041 8/1967 Damaskus ..206/63.2 3,255,873 6/1966 Speelman... ...206/43 X 3,107,785 10/1963 Roehr 206/632 2,400,722 5/1946 Swan ..206/43 Primary Examiner- Leonard Summer Attorney-McGlew and Toren [57] ABSTRACT 8 Claims, 4 Drawing Figures agsamm PATENTEU JAMES I972 INVENTOR M w m Jul-rm: 1

Mmm mm IDIEVICIE IFOR PRIESERVING DRUGS IFUIR INJECTION SUMMARY OF THE INVENTION This invention relates to a method of and device for preserving drugs, and more particularly to a method of and device for preserving inoculums, such as BCG, PPD etc., or other drugs for injection, such as SLO, in such a small quantity as to be used for a small number of persons such, for example, as several persons.

In general, inoculums for use in preventive inoculation are preserved in large containers, such as a large bottle, capable of containing such inoculums for a large number of persons, such for example, as 20 to 100 or more, for the purpose of making a collective inoculation.

However, when it is desired to inoculate only several persons or less, to open such container containing such a large amount of inoculum is disadvantageous from an economical point of view, since once the container is opened and part of the contents is used, the remainder is inevitably wasted.

On the other hand, in the case a small amount of inoculum is preserved in a small bottle or the like, the disadvantage is that lots of the inoculum contained in the container, for example, more than a half of it will adhere to the interior face of the container and will become useless.

The present invention is intended to eliminate such inconveniences and disadvantages indicated with conventional containers of this kind.

It is, therefore, one object of the present invention to provide a device for preserving inoculums, injections or other drugs for use in injection in such a small quantity as to be suitable for use for a small number of persons such, for example, as several persons of less, so that when it is desired to in oculate or inject such a small number of persons, the injector can economically use the drug preserved in the container.

It is another object of the present invention to provide a drug container unit for use in connection with inoculation or injection, comprising a needle assembly and a drug for injection preserved in said needle assembly, and adapted to be used conveniently.

It is a further object of the present invention to provide a drug container unit of the type stated, which is small in size and light in weight so as to be freely portable.

It is a still further object of the present invention to provide a method of preserving drugs for use in injection in such a small quantity as to be conveniently dispensed to a small number of persons, such, for example, as several persons or less.

It is yet another object of the invention to provide a method for the purpose stated, which is capable of preserving such drugs for a considerably long period of time.

These and other objects an advantages of the invention will become apparent upon reading the following detailed descrip tion of the invention in conjunction with the accompanying drawings in which:

FIGS. I through d are longitudinal cross-sectional views, in an enlarged scale, of embodiments of the present invention, respectively.

In the drawing like portions or parts are designated with like characters or numerals.

Referring to FIG. I, there is shown a drug preservation container unit A for use in inoculation or injection. The unit A comprises a relatively small vertically elongated cylindrical casing I with its upper end In opened which may be made ofa glass, a metal or a synthetic resin, a support member 2 made of a flexible and soft rubber or synthetic resin, a needle assembly S composed of a needle 3 and a cup member 4i fixed to the base 3a of the needle and intercommunicating with the nee dle, and a cap 5 for closing the opening of the casing I.

The support member 2 is provided with a base portion 2a adapted to be snugly inserted in the casing l and to he placed on the bottom wall 1b, and with a protrusion 2b protruding upwardly from the upper face of the base portion 2a and adapted to be pricked by the sharpened tip 3b of needle 3.

The cap 5 has a flat portion 5a having the diameter corresponding substantially to the outside diameter of the cylindrical casing ll and is provided with an inverted cup-shaped portion 5b depending from the flat portion 5a and arranged to be snugly inserted in the cup member 4! of needle assembly S.

The depth or height of the casing l is designed so that when the cap 5 is placed on the upper end Ila of casing t after the needle 3 of the needle assembly S has been stuck into the support 2 at its tip portion, the cup-shaped portion 5b of the cap is brought into engagement with the upper portion of the inner peripheral face of cup member 4i of the needle assembly.

Before sealing the upper opening of easing l, and after the needle assembly 5 has been vertically held within the casing l by pricking the tip 3b of needle 3 into the support member 2, a predetermined amount of inoculum 6 or drug for injection is put into the cup member 4. In this case, the inoculum or drug thus put into the cup member is prevented from flowing off through the needle 3, because the opening of the tip 3b is sealingly closed by the portion, surrounding the tip portion, of the elastic support 2 which is in pressure contact with said tip portion. Then, the inoculum or drug in the cup member 4 is subjected to application of the process of freezedrying which is often applied to, for example, foods for preservation.

Upon application of the process of freeze'drying to the drug, the upper opening of easing l is sealed with the cap 5 airtight by interposing between the entire top face of casing I and the underside of the cap 5 a packing material 7 and by applying a pressure to said cap to press the same against the top face of said casing. The packing material which is suitable for use in the sealing is, for example, an atactic polypropylene, an atactic polyethylene, their mixed compounds, etc. In the illustrated embodiment, the casing I is sealed under a reduced atmospheric pressure.

When it is desired to sue the container unit A for inoculation or injection, first, the cap 5 is removed and the needle assembly S is drawn out and attached to the glass cylinder of a conventional syringe, not shown, and then a necessary liquid for dissolving the contents is fed into the cup member 4 through the needle 3 by manipulating the plunger of the syringe in conventional manner. With this operation, the preserved contents is easily dissolved and flows into the glass cylinder in a liquid state, thus enabling the injector to practice injection.

The drugs to be preserved in accordance with the present invention may either be of liquid or powder or of any other form as long as they are for use in injection and are suited for the application of the process of freeze-drying.

Referring now to FIG. 2, there is shown a variant B of the drug preservation container unit A shown in FIG. I. As shown in FIG. 2, the unit B is provided with a cuplike portion 20 having bore 2d and extending vertically upwardly from the protruding portion 2b of the support 2. The depth of the bore 20. is made slightly shorter than the length of the needle 3 so that when the needle 3 is stuck at its tip into the protruding portion 2b, the cup member 4 of the needle assembly S is brought into contact at its bottom portion with the top surface of the cuplike portion 20, thereby enabling the needle assembly S to be securely supported by the support member 2.

Thus, the embodiment illustrated in FIG. 2 is the same as the embodiment previously described. in construction, with the exception of the provision of the cuplike portion 2c. The manner of assembling the unit and the method of preserving drugs in this instance are also the same as those in the first em bodiment and further description as to these and other matters will be omitted.

Referring now to FIG. 3, there is shown another drug preservation container unit C according to the present invention. In the illustrated embodiment, the: casing IA is made ofa metal, such as aluminum and is provided at its upper portion adjacent the upper end lAa with a contracted portion llAc defining the upper opening of the casing. The support 2A inserted in the casing IA is composed of an open-ended cylinder ZAc of plastics, such as polyethylene, and a pad member 2Aa of flexible and soft rubber or plastics into which the tip portion of the needle 3 is stuck. The support 2A is placed on the bottom lAb of casing 1A in an upright positioned as shown.

The cup member 4A of the needle assembly S vertically supported by the support 2A within casing 1A is covered with a packing 8 of plastics, such as an urethane foam, inserted in the upper opening of easing 1A. After the packing 8 has been inserted in the opening, the casing 1A is sealed with a flat cap 5A with the intermediary of the packing material 7 previously described. In the illustrated embodiment, the casing 1A is sealed under a reduced atmospheric pressure.

After the opening of easing 1A has been sealed with cap 5A, the head portion of casing 1A with cap 5A is covered with an aluminum foil 5A for the purpose of protection of the cap 5A.

The manner of assembling the unit C and the method of preserving drugs in this instance are almost the same as those in the second embodiment B and further description as to these and other matters will not be made.

Referring now to FIG. 4, there is depicted another drug preservation container unit D according to the invention. In this embodiment, the casing 18 is made of a solid synthetic resin and is tapered inwardly upwardly at [B and terminates in the open end lBa. The casing 1B is also formed inside thereof with shoulder portions lBd for receiving the lower portion of cup member 48 of the needle assembly S. A support member 2B is inserted in the casing 18 and placed on the bottom lBb of casing 18.

The cap 58 is provided with a cylindrical skirt B0 depending from the top portion 58a and having the same diameter as the casing 1B, and also with a inverted cuplike portion 58b, and is arranged to be snugly mounted on the tapered portion 18C of the casing 1B. In this embodiment, the casing 18 is sealed with the cap 53 under a normal atmospheric pressure. The casing 13 covered with the cap 58 is sealed in an aluminum foil wrapper 9, as shown in FIG. 4, to prevent moisture. In this instance, the casing 1B is preferably filled with nitrogen gas. The manner of assembling the unit and the method of preserving drugs in this instance are almost the same as those of the foregoing embodiments and, to avoid repetition further explanation as to these and other matters will be omitted.

As may be seen from the foregoing, in accordance with the present invention, the drug for use in inoculation or injection is preserved in the cup member of the needle assembly and, for example, when several persons are inoculated with the preserved substance, the inoculation for at least the first person can be made by the needle without using other needle. Further, in accordance with the invention, the tip of the needle is protected by the flexible support by being kept stuck into therein, so that the tip of the needle can be kept free from damage.

What we claim is:

l. A drug preservation container unit for use in connection with injection, comprising a relatively small vertically elongated casing with its upper end opened, a support of flexible and soft rubber mounted within said casing, a needle assembly composed of a needle and a cup member fixed to the base thereof and connectable to the cylinder of a syringe, said needle assembly being held in an upright position within said casing, the needle of said needle assembly being stuck into said support at its tip portion, a predetermined amount of drug for use in injection, said drug being contained in said cup member and subjected to the process of freeze-drying for preservation and a cap sealing the upper opening of said casing and of said cup.

2. A drug preservation container unit as set forth in claim I, wherein said cap is provided with an inverted cuplike portion depending therefrom and arranged to cover the opening of the cup member of said needle assembly.

3. A drug preservation container unit as set forth in claim 1, wherein said support is provided with a hollow cylindrical portion arranged to receive at its upper end the cup member of said needle assembly.

4. A drug preservation container unit as set forth in claim 1,

wherein said support is composed of a pad and an open-ended cylinder in which said pad is inserted, said pad being of flexible and soft rubber and arranged to allow the tip portion of said needle to stick thereinto, said open-ended cylinder being arranged to receive at its upper end the cup member of said needle assembly.

5. A drug preservation container unit as set forth in claim 4, wherein a packing is inserted in said casing between said cap and said cup member to cover the latter.

6. A drug preservation container unit as set forth in claim 1, wherein said unit is sealed in an aluminum foil wrapper.

7. A drug preservation container unit as set forth in claim 1, wherein said casing is of metal.

8. A drug preservation container unit as set forth in claim I, wherein said casing is of plastic material.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2400722 *Jul 10, 1944May 21, 1946Swan Harry LHypodermic needle case
US3107785 *Oct 4, 1960Oct 22, 1963Brunswick CorpSyringe-container structure
US3255873 *Oct 11, 1963Jun 14, 1966Propper Mfg Company IncCombination sealing and dispensing device
US3337041 *Oct 23, 1965Aug 22, 1967Damaskus Charles WLayered lyophilized product in a disposable syringe
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3868015 *Sep 14, 1973Feb 25, 1975Thompson Larry GInsect bite kit
US4446967 *May 7, 1982May 8, 1984Halkyard Douglas RGermicide sleeve for dental and medical instruments
US4735311 *Apr 9, 1986Apr 5, 1988The West CompanyNeedle shield assembly
US4848569 *Sep 20, 1988Jul 18, 1989Leishman Layne SApparatus and method for disposing of contaminated needles
US5085647 *Mar 7, 1991Feb 4, 1992Sherwood Medical CompanyRigid needle cover with needle sealing plug and method of manufacture thereof
US5152394 *Sep 10, 1991Oct 6, 1992Mcdonald, Withers & Hughes, Inc.Personal use syringe dispensing and collecting system
US5161681 *May 3, 1991Nov 10, 1992Kemp David RSafety container for hypodermic syringes
US5167193 *May 14, 1991Dec 1, 1992Mcdonald, Withers & Hughes, Inc.Medical wastes disposal system
US5172808 *May 17, 1989Dec 22, 1992John BrunoDevice for safely transporting one or more hypodermic needles or the like from point of use to point of ultimate disposal
US5230428 *Sep 26, 1991Jul 27, 1993Mcshane Jerry MApparatus for the disposal of contaminated needles
US5259501 *Sep 10, 1991Nov 9, 1993Mcdonald, Withers & Hughes, Inc.Personal use syringe collecting and disposing system
US5385105 *May 23, 1994Jan 31, 1995Mcdonald, Withers & Hughes, Inc.Burnable wastes collector with liquid absorber and identifier
US5431280 *Mar 17, 1994Jul 11, 1995Humagen Fertility Diagnostics Inc.Closure cap for holding pipets during shipping
US5458072 *Apr 6, 1994Oct 17, 1995Hughes; David W.Disposable medical wastes collector with liquid absorber
US5483973 *Sep 23, 1993Jan 16, 1996Becton, Dickinson And CompanyNeedle stopper and needle removal device
US6503230Aug 1, 2001Jan 7, 2003Robert B. OdellNeedle shield for a prefillable syringe
Classifications
U.S. Classification206/229, 206/365
International ClassificationA61M5/00, B65B31/02, A61J1/00, A61M5/32, A61J1/06, A61M5/31
Cooperative ClassificationA61J1/00, A61M5/3202, A61M5/002, A61J1/06, A61M2005/3109, A61M5/00
European ClassificationA61J1/00, A61M5/00, A61M5/00P, A61J1/06, A61M5/32B