|Publication number||US3640269 A|
|Publication date||Feb 8, 1972|
|Filing date||Oct 24, 1969|
|Priority date||Oct 24, 1969|
|Publication number||US 3640269 A, US 3640269A, US-A-3640269, US3640269 A, US3640269A|
|Inventors||Delgado Jose M R|
|Original Assignee||Delgado Jose M R|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (8), Referenced by (92), Classifications (8)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent Delgado Feb. 8, 1972  FLUID-CONDUCTING INSTRUMENT INSERTABLE IN LIVING ORGANISMS  Inventor: Jose M. R. Delgado, 50 Autumn St., New
Haven, Conn. 06511  Filed: Oct. 24, 1969 [211 App]. No.: 869,170
 US. Cl. ..128/2 R, 128/2 F, l28/2.1,
128/213, 128/260, 128/348  Int. Cl. ..A6lb 5/00  FieldofSearch ..l28/2,2.05,2 1,213,214, 128/260, 261, 348-351, 240-241, 239; 424/16, 19;
 References Cited UNITED STATES PATENTS 3,093,831 6/1963 Jordan ..3/1 3,279,996 10/ 1 966 Long et a1 ..424/ 19 3,310,051 3/1967 Schulte ..128/350 X 3,313,289 4/1967 Kapral ..3/1 X 3,504,664 4/1970 Haddad 128/2.l R 3,512,517 5/1970 Kadish et al. ..128/2 3,520,298 7/1970 Lange ...128/213 3,527,220 9/1970 Summers ..128/260 Primary Examiner-Dalton L. Truluck Att0rneyWalter Spruegel ABSTRACT An instrument for insertion in living organisms, having two flexible fluid-impermeable tubes open at one end and provided at the other end with enlarged bag formations which are self-sealing after being punctured with a needle, and a porous bag closed except for an open end with which the open tube ends communicate, with the latter being received in and attached to the open bag end and sealed from the outside of the bag.
5 Claims, 3 Drawing Figures FLUID-CONDUCTING INSTRUMENT INSERTABLE IN LHVING ORGANISMS This invention relates to medical instruments in general, and to instruments for passing fluids into and from living organisms in particular.
The present invention is concerned with instruments that are insertable or implantable in living organisms for passing fluids therefrom and/or thereinto for medical-scientific and therapeutic purposes. Prior instruments of this type are known, but these aremostly in the form of needles or cannulae which, while serving for highly useful purposes, are limited in their applications. Particularly lacking among these prior.
instruments is one single instrument which readily lends itself to any of various procedures involved in medical techniques, such as supplying a liquid medium to a localized part of a living organism at a prescribed rate over a desired, including relatively long, time span with or without human supervision, extracting matter in liquid form from a localized part of .a living organism, and circulating liquid medium through a localized part of a living organism for any desired length of time. Further, in using prior instruments of this type in living organisms, there is always the risk of introducing micro-organisms into,.and thus contaminating, these organisms.
It is among the objects of the present invention to provide an instrument of this type which not only lends itself readily to any -of the aforementioned various procedures involved in medical techniques, but the use of which in any part of a living organism does not involve any risk of introducing micro-organisms into the organism dealt with.
It is another object of the present invention to provide an instrument of this type which for insertion in a-living organism includes preferably flexible tubing, and for displacement of fluid into or from an organism provides the tubing with a closed lead end and with a porous wall over a length of the tubing near, and preferably extending to, the closed lead end. With this arrangement, the inserted instrument with its porous wall in a desired location in a living organism, may be attended to at its outer end, either to introduce into the tubing a liquid for its gradual, dosed, seepage through the porous wall and perfusion of the organism, or to draw liquid from the organism through the porous wall into and out of the tubing.
It is a further object of the present invention to provide an instrument of this type in which the porosity of the aforementioned wall of the tubing is such that the pores willblock the passage of micro-organisms but will permit the passage of fluids involved in the various medical procedures.
Another object of the present invention is to provide an instrument of this type in which the aforementioned lead end and porous wall of the tubing are formed by a separate porous application bag which is joined and open to the tubing and is preferably flexible and of sufiicient volume to hold a substantial quantity of liquid. With this arrangement, the tubing may be of any nonporous material well tolerated by living tissue, such as stainless steel or Teflon, for example, while the application bag may be of any suitable porous material, such as polypropylene sheet of proper pore size, for example, which may readily be joined to the tubing either directly or by a binder. Further, the bag mayrhold liquid, such as a medicating drug, for instance, in sufficient quantity to perfuse an affected part of a living organism for a relatively long period.
A further object of the present invention is to provide an instrument of this type of which the tubing is in the form of twin tubes side-by-side at least over their insertable length, and the aforementioned porous application bag is joined and open to both tubes. With this arrangement, charging the bag of the inserted instrument with a liquid is expedited as well as facilitated, in that the liquid may be introduced through one tube while the bag is vented through the other tube. Further, the inserted instrument lends itself to the additional procedure of circulating a liquid for any length of time through the affected area within an organism without possible contamination of the latter by micro-organisms. This is achieved by connccting the outer ends of the tube with the outlet and inlet of a pump so as to form through the tubes and bag a circulatory passage via the pump andkeep this passage filled with liquid. With the liquid in this circulatory passage being then subjected to the positive and negative pressure from the operating pump, the liquid is displaced from the application bag into the organism and back from the organism into the bag. The inserted'instrument'also lends itself still further to electric stimulation of, and recording from, a living organism, such as the brain, for example, by introducing through the tubing an insulated conductor with its bare conductive tip extending into the application bag, and filling the bag with an electrolite, such as spinal fluid, which by its perfusion of the cerebral tissue around the bag establishes electrical contact between the tissue and conductor. j
It is another object of the present invention to provide instrument of this type of which the outer ends of the twin tubes are closed, and are preferably formed as enlarged reservoir bags of a material which allows repeated puncturing with a needle without giving rise to leakage after retraction of the needle. With this arrangement, the instrument lends itself particularly well, though not exclusively, to implantation, with the reservoir bags being arranged subcutaneously but readily accessible with needles through the skin overlying these bags, so that the instrument lends itself to any and all of the aforementioned procedures. Further, with the entire instrument closed except for the pores in the application bag, the rate of seepage of a liquid from theapplication bag into a living organism, or vice v'ersa, may be varied considerably by superatmospheric or subatmospheric air or gas pressure applied to the closed instrument through a needle into either of the reservoir bags.
Further objects and advantages will appear to'those skilled in the art fromthe following, considered in conjunction with the accompanying drawings.
In the accompanying drawings, in which certain modes of carrying out the present invention are shown for illustrative purposes:
FIG. 1 is a section through an instrument embodying the present invention, with the instrument shown in this instance implanted in a living organism;
FIG. 2 is a section through an instrument embodying the invention in a modified manner; and
FIG. 3 is a fragmentary enlarged view of a prominent part of either instrument of FIG. 1 or FIG. 2.
Referring to the drawings, and more particularly to FIG. 1 thereof, the reference numeral 10 designates an instrument which is insertable into living organisms for passing fluids therefrom and/or thereinto for medical-scientific and therapeutic purposes. The present instrument is shown in this instance inserted, and more particularly implanted, in a living brain B beneath a skull S. The instrument is adapted for injecting into, or retracting from, a living organism fluid, and more particularly various liquids. To this end, the instrument has as its major components fluid-conducting tubing 12 and an application bag 14 at the inner end 16 of the tubing 12. The tubing 12 consists of a plurality of tubes 18, two in this instance, which are of a material that is impermeable to fluids and well tolerated by the tissue, such as Teflon or some other suitable plastic, or stainless steel. Some of these materials lend flexibility to various desired degrees to the tubes.
The application bag 14, which is preferably a separate part, is in this instance elongated and is closed at its lead-in end 20 and open at its other end 22. The tubes 18 project with their open ends 16 into the open end 22 of the bag 14 and are there suitably attached to each other so that the tubes and bag are sealed from the outside of the bag. In accordance with an important aspect of the invention, the application bag 14 is porous for the displacement of fluid, and especially liquids, thereinto and therefrom. The bag 14 may be formed of any suitable porous material, such as polypropylene, polysulfone or cellulose acetate, for example. The tube ends [6 may be attached to each other and to the surrounding bag end 22 by any known method of bonding plastic to plastic or stainless steel, depending on the materials used. The remainder of the tubes L8 are preferably unattached to each other so that they may be separated, for example to diverge with their outer ends 24 in the fashion shown in FIG. 1.
The outer ends 24 of the tubes 18 may be open for injection or retraction of fluid into or from the tubes. Preferably and advantageously, however, the outer ends 24 of the tubes 18 are formed as closed reservoirs in the form of bags 26 which may be formed integrally with, or suitably joined to, the respective tubes 18. These bags 26 are of any suitable material which allows repeated puncturing with a needle 28 and self-seals after each needle retraction. Among such suitable materials is silicone rubber, for example.
While dimensions of the tubes 18, application bag 14 and reservoir bags 26 may obviously vary for applications of the instrument to difierent living organisms, there are given, by way of example only, the dimensions of a specific instrument actually implanted in a living brain as shown. Thus, each of the tubes 18 had an outer diameter of about 0.9 mm., the application bag 14 measured about 1.8 mm. in diameter and about 5 mm. in length, while each of the reservoir bags measured about 5 mm. in width w and about mm. in diameter. The instrument was implanted in the brain B by conventional surgical procedure, with the tubes 18 being secured in the drilled hole h in the skull S with a suitable cement c, in this instance acrylic cement, and the reservoir bags 26 being in this instance placed subcutaneously, i.e., below the scalp s, as shown, and anchored to the skull S as by the vitallium screws (not shown). In introducing the instrument in the brain, the application bag 14 was directed to the desired location and also depth in the brain with the aid of a fine metallic introductor directed by the rnicromanipulator of a stereotaxic instrument.
The instrument thus implanted in the exemplary brain B can be used for various purposes. One of these purposes is intracerebral injection of a drug solution. To this end, the needle 28 of a charged syringe 32 is entered through the scalp 5 into the subcutaneous bag 26a, for example, whereupon the plunger of the syringe is driven forward to eject the drug charge into the bag 26a while the instrument is being simultaneously vented at the other subcutaneous bag 26 through a needle 28 of another syringe 34 (FIG. 1). Drug solution of any desired amount may thus be introduced in the instrument. This drug solution will then enter the brain area around the application bag 14 at a readily controlled volumetric rate. Control over the rate of displacement of the solution from the application bag 14 is achieved by the pores p in this bag (FIG. 3) which lend it the desired porosity, by the total volume of drug solution injected into the instrument, by the selective pressure within the instrument, and by the concentration of the drug solution. The particular application bag used in the aforementioned specific instrument had a pore size below 0.2 microns and water permeability above 60 ml./min./cm. but these data are given only by way of example and not limitation. Insofar as the pressure within the instrument is concerned, this may be regulated anywhere from the subatmospheric to superatmospheric by proper manipulation of the syringes 32 and 34, as will be readily understood. Further, the higher the concentration of the drug solution, the more rapid will be its displacement from the application bag 14 into the brain regardless of the pressure of the instrument. Thus, even if there is no pressure on the solution in the instrument, i.e., if the pressure therein is approximately atmospheric, the solution will pass from the porous bag 14 into the brain at a rate depending on its concentration. It is thus readily apparent that by means of the present instrument a drug solution may perfuse the brain at a rate and over a time span within relatively wide limits.
The exemplary instrument may serve for numerous other purposes. Thus, it may serve for intracerebral collection. To this end, the instrument is filled with a suitable solution, such as synthetic spinal fluid, for example, and a negative pressure is maintained in the instrument by injecting slowly and placing the collecting syringe below the level of the head, with the negative pressure being proportional to the diameter of the needle used and to the differential levels between the injection and collection syringes.
Another application of the instrument is for recirculation of a fluid. To this end, a pump is interposed between the applied syringes to complete a recirculation path through the instrument, with the collected fluid being reintroduced into the subcutaneous injection bag and recirculated intracerebrally for as long as desired. In this application, for example, neurochemical equilibrium between brain and perfused fluids may be established within a certain period of time, increasing the concentration of neurohumors released from the brain into the synthetic spinal fluid.
Still another exemplary application of the instrument is for electrical stimulation and recording. To this end, one of the subcutaneous bags is punctured with a fine needle, whereupon an insulated Teflon-coated stainless steel wire with a bare conductive tip is through the needle introduced as a stylet to establish electric contact with the cerebral tissues around the application bag through intermediation of an electrolite, such as spinal fluid, in the instrument.
In all of these and still other applications, no micro-organisms may enter the living organ because the pore size of the porous application bag is in any event such as to block the passage of organisms. Pore sizes of below 0.5 microns are recommended to that end.
With the instrument implanted as in the example shown, the same is ready for use at any time, but during periods of rest there is no instrumentation breaking the continuity of the skin.
Short or long term intracerebral injections will have important scientific and therapeutic applications. Following are a few exemplary ones of these applications:
a. to increase the dopamine content of the pallidum in patients with Parkinsons disease,
b. to inhibit the abnormal functioning of localized areas of the brain by slow, chronic infiltration with blocking agents,
c. to administer antiepileptic medication to the site of the origin of disturbed electrical activity in patients with epilepsy, and
d. electrical stimulations and recordings which may provide basic information for diagnostic and therapeutic purposes. In addition, analysis of chemicals released locally by the brain may orient the diagnosis of cerebral disturbances and may guide the administration of drugs.
While the instrument is shown implanted in a brain in the example shown in FIG. I, it may, of course, be implanted, or merely inserted, in any other living organism with or without requiring surgery for its introduction into the organism.
Reference is now had to FIG. 2 which shows a modified instrument 10a that is like the described instrument 10 of FIG. 1, except that there is only one tube 18a and one outer bag 26b. The application bag 14a is porous, the same as the bag 14 of the instrument 10. The present instrument 10a lends itself to similar applications as the instrument 10, though with obvious limitations owing to the single tube 18a and single outer bag 26b.
1. An instrument insertable into living organisms, comprising two flexible fluid-impermeable tubes of the same uniform cross-sectional size, with said tubes being open at one end and provided at their other ends with enlarged flexible fluid-impermeable bag formations which are puncturable with a hypodermic needle and self-sealing on needle retractions; and a separate elongated porous bag having an open end and being otherwise closed, and receiving in its open end side-by-side disposed endlengths of said tubes including said open ends thereof, and said tube endlengths being attached to said open bag end and sealed from the outside of said bag, with other endlengths of said tubes including said bag formations being unattached to each other, and said porous bag defining a counterflow path from either of said open tube ends to the other open tube end.
2. An instrument as in claim 1, in which said bag formations are of substantially the same volume.
3. An instrument as in claim I, in which said tubes are unattached to each other except at their attachment to said open bag end.
4. An instrument as in claim 1, in which said endlengths of said tubes received in said open bag end are of the same length. I
5. An instrument as in claim 1, in which the pores of said porous bag are of a size below 0.5 microns. 5
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3093831 *||Oct 22, 1959||Jun 18, 1963||Jordan Gerhard Paul Wilhelm||Artificial gland|
|US3279996 *||Aug 28, 1962||Oct 18, 1966||Folkman Moses Judah||Polysiloxane carrier for controlled release of drugs and other agents|
|US3310051 *||Dec 10, 1963||Mar 21, 1967||Schulte Rudolf R||Surgical reservoir for implantation beneath the skin|
|US3313289 *||Jun 23, 1964||Apr 11, 1967||Kapral Frank A||Implant chamber|
|US3504664 *||Dec 17, 1965||Apr 7, 1970||Instrumentation Labor Inc||Sensing element support|
|US3512517 *||Nov 30, 1964||May 19, 1970||Beckman Instruments Inc||Polarographic method and apparatus for monitoring blood glucose concentration|
|US3520298 *||Aug 10, 1967||Jul 14, 1970||Lange Kurt||Peritoneal dialysis apparatus|
|US3527220 *||Jun 28, 1968||Sep 8, 1970||Fairchild Hiller Corp||Implantable drug administrator|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3765414 *||Mar 10, 1972||Oct 16, 1973||Hydro Med Sciences Inc||Drug release system|
|US3783868 *||May 6, 1971||Jan 8, 1974||Gulf Oil Corp||Percutaneous implant|
|US3797485 *||Mar 26, 1971||Mar 19, 1974||Alza Corp||Novel drug delivery device for administering drug into blood circulation in blood vessel|
|US3971376 *||Oct 2, 1974||Jul 27, 1976||Ceskoslovenska Akademie Ved||Method and apparatus for introducing fluids into the body|
|US3983864 *||Jul 7, 1975||Oct 5, 1976||Airco, Inc.||Method and apparatus for in vivo blood gas analysis|
|US3996933 *||Oct 4, 1975||Dec 14, 1976||Morton Gutnick||Intrauterine contraceptive devices and processes|
|US4016864 *||Sep 8, 1975||Apr 12, 1977||Airco, Inc.||Blood gas catheter|
|US4102998 *||Jul 1, 1976||Jul 25, 1978||Morton Gutnick||Process for the prevention of venereal disease|
|US4159720 *||Nov 28, 1977||Jul 3, 1979||Burton Andrew F||Infusion of liquids into tissue|
|US4160454 *||Feb 14, 1977||Jul 10, 1979||University Of Utah||Implantable catheter system|
|US4179757 *||May 10, 1976||Dec 25, 1979||Owens-Illinois, Inc.||Biocompatible articles having high permeability to gases derived from polysulfones|
|US4184497 *||Aug 26, 1977||Jan 22, 1980||University Of Utah||Peritoneal dialysis catheter|
|US4186745 *||Feb 15, 1978||Feb 5, 1980||Kauzlarich James J||Porous catheters|
|US4235231 *||Jul 28, 1978||Nov 25, 1980||Dr. E. Fresenius Chemisch Pharmazeutische Industrie KG||Portable artificial kidney|
|US4253201 *||May 24, 1979||Mar 3, 1981||Ross David A||Prosthesis with self-sealing valve|
|US4256102 *||May 14, 1979||Mar 17, 1981||Monaco Anthony P||Subcutaneous dialysis system|
|US4265249 *||Jul 28, 1978||May 5, 1981||Dr. E. Fresenius Chemisch Pharmazeutisch Industrie Kg||Catheter device and system for continuous chemical analysis of body fluids in vivo|
|US4360031 *||Sep 11, 1980||Nov 23, 1982||Medtronic, Inc.||Drug dispensing irrigatable electrode|
|US4464178 *||Nov 25, 1981||Aug 7, 1984||Dalton Michael J||Method and apparatus for administration of fluids|
|US4557724 *||Aug 12, 1983||Dec 10, 1985||University Of Utah Research Foundation||Apparatus and methods for minimizing cellular adhesion on peritoneal injection catheters|
|US4581012 *||Dec 5, 1984||Apr 8, 1986||I-Flow Corporation||Multilumen catheter set|
|US4681564 *||Oct 21, 1985||Jul 21, 1987||Landreneau Michael D||Catheter assembly having balloon extended flow path|
|US4687001 *||Feb 14, 1977||Aug 18, 1987||The United States Of America As Represented By The Department Of Health And Human Services||Subcutaneous fluid and culture chamber and implant technique|
|US4692146 *||Oct 24, 1985||Sep 8, 1987||Cormed, Inc.||Multiple vascular access port|
|US4694832 *||Nov 22, 1985||Sep 22, 1987||Ungerstedt Carl U||Dialysis probe|
|US4695273 *||Apr 8, 1986||Sep 22, 1987||I-Flow Corporation||Multiple needle holder and subcutaneous multiple channel infusion port|
|US4710174 *||Dec 16, 1985||Dec 1, 1987||Surgical Engineering Associates, Inc.||Implantable infusion port|
|US4726381 *||Jun 4, 1986||Feb 23, 1988||Solutech, Inc.||Dialysis system and method|
|US4738657 *||Sep 30, 1985||Apr 19, 1988||Mcghan Medical Corporation||Self-sealing injection reservoir|
|US4763658 *||Jul 29, 1987||Aug 16, 1988||Solutech, Inc.||Dialysis system 2nd method|
|US4765339 *||Jul 29, 1987||Aug 23, 1988||Solutech, Inc.||Closed loop dialysis system|
|US4767410 *||Jun 19, 1987||Aug 30, 1988||Surgical Engineering Associates, Inc.||Implantable infusion port|
|US4774955 *||Jul 29, 1987||Oct 4, 1988||Solutech, Inc.||Programmable dialyzer system analyzer and method of use|
|US4781695 *||Jul 11, 1986||Nov 1, 1988||Dalton Michael J||Implantable fluid dispenser|
|US4790826 *||Mar 28, 1986||Dec 13, 1988||Elftman Nancy W||Percutaneous access port|
|US4798584 *||Mar 14, 1988||Jan 17, 1989||Mcghan Medical Corporation||Self-sealing injection reservoir|
|US4857053 *||Aug 29, 1988||Aug 15, 1989||Dalton Michael J||Matrix septum|
|US4894057 *||Jun 19, 1987||Jan 16, 1990||Howes Randolph M||Flow enhanced multi-lumen venous catheter device|
|US5074878 *||Apr 19, 1991||Dec 24, 1991||Medical Engineering Corporation||Tissue expander and method|
|US5191900 *||Apr 10, 1991||Mar 9, 1993||The Board Of Trustees Of The University Of Illinois||Dialysis probe|
|US5487739 *||Jun 2, 1995||Jan 30, 1996||Brown University Research Foundation||Implantable therapy systems and methods|
|US5554148 *||May 26, 1995||Sep 10, 1996||Brown University Research Foundation||Renewable neural implant device and method|
|US5848989 *||Jun 5, 1997||Dec 15, 1998||Davinci Biomedical Research Products, Inc.||Implantable port with low profile housing for delivery/collection of fluids and implantation method|
|US5931774 *||Oct 7, 1996||Aug 3, 1999||Proxima Therapeutics, Inc.||Inflatable devices for tumor treatment|
|US6043273 *||Aug 23, 1999||Mar 28, 2000||Duke University||Compositions, apparatus and methods for facilitating surgical procedures|
|US6060454 *||Aug 7, 1998||May 9, 2000||Duke University||Compositions, apparatus and methods for facilitating surgical procedures|
|US6061587 *||May 15, 1997||May 9, 2000||Regents Of The University Of Minnesota||Method and apparatus for use with MR imaging|
|US6087394 *||Aug 23, 1999||Jul 11, 2000||Duke University||Compositions, apparatus and methods for facilitating surgical procedures|
|US6093180 *||Aug 18, 1997||Jul 25, 2000||Medtronic, Inc.||Intraparenchymal infusion catheter system|
|US6101412 *||Dec 21, 1999||Aug 8, 2000||Duke University||Compositions, apparatus and methods for facilitating surgical procedures|
|US6127410 *||Aug 23, 1999||Oct 3, 2000||Duke University||Compositions, apparatus and methods for facilitating surgical procedures|
|US6141589 *||Aug 23, 1999||Oct 31, 2000||Duke University||Switch control for external pacing system|
|US6179826||Oct 29, 1996||Jan 30, 2001||Brown University Research Foundation||Implantable therapy systems and methods|
|US6414018||Jan 28, 2000||Jul 2, 2002||Duke University||Compositions, apparatus and methods for facilitating surgical procedures|
|US6551290||Mar 31, 2000||Apr 22, 2003||Medtronic, Inc.||Catheter for target specific drug delivery|
|US6594880||May 23, 2001||Jul 22, 2003||Medtronic, Inc.||Intraparenchymal infusion catheter system|
|US6711436||Sep 27, 1999||Mar 23, 2004||Duke University||Compositions, apparatus and methods for facilitating surgical procedures|
|US6852106||Dec 13, 2001||Feb 8, 2005||Control Delivery Systems, Inc.||Implantable refillable and ported controlled release drug delivery device|
|US6896665||Dec 10, 2001||May 24, 2005||Applied Medical Research||Gastrostomy device package and method of assembly|
|US6945969||Jul 26, 2000||Sep 20, 2005||Medtronic, Inc.||Catheter for target specific drug delivery|
|US7069634||Feb 24, 2000||Jul 4, 2006||Medtronic, Inc.||Method for manufacturing a catheter|
|US7077822 *||Sep 13, 2000||Jul 18, 2006||The University Of Iowa Research Foundation||Stereotactic hypothalamic obesity probe|
|US7153292||Apr 21, 2004||Dec 26, 2006||Medtronic, Inc.||Catheter for target specific drug delivery|
|US7670311 *||Nov 4, 2005||Mar 2, 2010||Cordis Corporation||Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue|
|US7813811 *||Feb 8, 2007||Oct 12, 2010||Neuropace, Inc.||Refillable reservoir lead systems|
|US7844345||Feb 8, 2007||Nov 30, 2010||Neuropace, Inc.||Drug eluting lead systems|
|US8048056||Feb 17, 2005||Nov 1, 2011||Applied Medical Research||Method of assembling a percutaneous gastrostomy device|
|US8160720 *||Sep 13, 2010||Apr 17, 2012||Neuropace, Inc.||Refillable reservoir lead systems|
|US8190270||Jan 10, 2012||May 29, 2012||Neuropace, Inc.||Refillable reservoir lead systems|
|US8423156||Feb 9, 2012||Apr 16, 2013||Neuropace, Inc.||Drug eluting lead systems|
|US8685106||Mar 1, 2012||Apr 1, 2014||Abraham Lin||Method of a pharmaceutical delivery system for use within a joint replacement|
|US20040199128 *||Apr 21, 2004||Oct 7, 2004||Medtronic, Inc.||Catheter for target specific drug delivery|
|US20050059954 *||May 19, 2004||Mar 17, 2005||Constantz Brent R.||Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue|
|US20060155242 *||Nov 4, 2005||Jul 13, 2006||Constantz Brent R||Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue|
|US20070167932 *||Mar 21, 2007||Jul 19, 2007||Felix Theeuwes||Local concentration management system|
|US20080195160 *||Feb 8, 2007||Aug 14, 2008||Wingeier Brett M||Refillable reservoir lead systems|
|US20080195227 *||Feb 8, 2007||Aug 14, 2008||Boling C Lance||Drug eluting lead systems|
|US20100094074 *||Oct 10, 2008||Apr 15, 2010||Hologic Inc.||Brachytherapy apparatus and methods employing expandable medical devices comprising fixation elements|
|US20100094075 *||Oct 10, 2008||Apr 15, 2010||Hologic Inc.||Expandable medical devices with reinforced elastomeric members and methods employing the same|
|US20100331762 *||Sep 13, 2010||Dec 30, 2010||Neuropace, Inc.||Refillable Reservoir Lead Systems|
|US20110004282 *||Aug 30, 2010||Jan 6, 2011||Neuropace, Inc.||Drug Eluting Lead Systems|
|DE102009001455A1||Mar 10, 2009||Sep 16, 2010||Trace Analytics Gmbh||Sampling device for attachment to e.g. hollow needle for sampling blood of human in chemical industry, has probe chamber formed as inner recess, and separation membrane surrounding inner recess for penetrating analytes from probe chamber|
|DE202007019544U1||Nov 16, 2007||Jun 18, 2013||Trace Analytics Gmbh||Probenahmevorrichtung|
|EP0134340A1 *||Aug 22, 1983||Mar 20, 1985||The University of Utah Research Foundation||Peritoneal injection catheter apparatus|
|EP0970724A3 *||May 15, 1992||Nov 29, 2000||Proxima Therapeutics, Inc.||Tumour treatment apparatus|
|WO1994015663A1 *||Dec 17, 1993||Jul 21, 1994||Brown University Research Foundation||Implantable therapy systems and methods|
|WO1996033756A1 *||Apr 15, 1996||Oct 31, 1996||Medtronic, Inc.||Bioretentive filtered infusion catheter|
|WO1998015315A1 *||Oct 6, 1997||Apr 16, 1998||Proxima Therapeutics Inc.||Inflatable devices for tumor treatment|
|WO1998052064A1 *||May 15, 1998||Nov 19, 1998||Regents Of The University Of Minnesota||Method and apparatus for targeted drug delivery into a living patient using magnetic resonance imaging|
|WO2002074381A2 *||Dec 13, 2001||Sep 26, 2002||Control Delivery Systems||Implantable refillable and rate controlled drug delivery device|
|WO2002074381A3 *||Dec 13, 2001||Jan 16, 2003||Control Delivery Systems||Implantable refillable and rate controlled drug delivery device|
|WO2008059050A2||Nov 16, 2007||May 22, 2008||Trace Analytics Gmbh||Sample taking device, and sample taking methods|
|U.S. Classification||600/573, 604/93.1, 604/175, 600/582|
|Cooperative Classification||A61M39/0208, A61M2039/0211|