|Publication number||US3650831 A|
|Publication date||Mar 21, 1972|
|Filing date||Mar 10, 1969|
|Priority date||Mar 10, 1969|
|Publication number||US 3650831 A, US 3650831A, US-A-3650831, US3650831 A, US3650831A|
|Inventors||Carlo Armando, Herrick Aaron B, Jungermann Eric|
|Original Assignee||Armour Dial Inc|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (9), Referenced by (93), Classifications (14) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Method of cleaning surfaces
US 3650831 A
A method of removing deposits of soil from surfaces, which comprises applying to said surfaces a caustic alkali including an acid-base color indicator, and applying an aqueous solution which is sufficiently acidic to substantially neutralize the caustic and visibly change the color of the caustic. The method has particular efficacy for the cleaning of the interior surfaces of ovens and similar surfaces.
United States Patent Jungermann et al.
[451 Mar. 21, 1972  METHOD OF CLEANING SURFACES  Inventors: Eric Jungermann, Chicago; Aaron B. Herrick, La Grange; Armando Carlo, Chicago, all of ill.
 Assignee: Armour-Dial, Inc., Chicago, Ill.
 Filed: Mar. 10, 1969  Appl. No.: 805,797
 US. Cl ..134/27, 134/40, 252/156, 252/408  Int. Cl ..B08b 3/08  Field of Search 1 34/27, 28, 29, 22, 40; 252/408, 103, 156
 References Cited UNITED STATES PATENTS Phair ..252/408 X Sutton...
Primary Examiner-Joseph Scovronek Assistant ExaminerD. G. Millman Attorney-Carl C. Batz and Richard G. l-larrer  ABSTRACT A method of removing deposits of soil from surfaces, which comprises applying to said surfaces a caustic alkali including an acid-base color indicator, and applying an aqueous solution which is sufficiently acidic to substantially neutralize the caustic and visibly change the color of the caustic. The method has particular efficacy for the cleaning of the interior surfaces of ovens and similar surfaces.
5 Claims, No Drawings METHOD OF CLEANING SURFACES This invention relates to a method of cleaning deposits of soils from surfaces, for example, the interior surfaces of ovens and the like.
The cleaning of the interior surfaces of household cooking ovens is a difficult, tedious, and lengthy chore. A widely used oven cleaner is the spread-on, sodium hydroxide or potassium hydroxide formulations that are messy to apply and must be handled with care as the highly caustic material is capable of injuring the user. MOre recently, aerosol oven cleaners having a considerably lower concentration of alkali and containing a nonionic or ionic detergent with a solvent suchas water or alcohol have appeared. However, they are generally not as effective as the higher caustic content cleaners, although safer to use than the highly caustic formulas.
In accordance with the present invention a method is provided for removing deposits of soils from surfaces by applying to such surfaces a caustic, an acid-base color indicator, and thereafter applying an aqueous acidic solution to substantially neutralize the caustic, such as to a pH between about 4 and 10.5. When the caustic has been substantially neutralized, a color change takes place due to the presence of the acid-base color indicator thereby indicating to the user that the surface can be wiped clean without the need of rubber gloves or the worry of skin irritation. In a preferred embodiment, the method comprises applying to such surfaces a caustic alkali foam containing an acid-base color indicator, and then applying sufficient aqueous acidic solution to the surface so as to substantially neutralize the caustic and to effect a change in color of the caustic. In the alternative the acid-base indicator may be included in the aqueous acidic solution or may be applied apart from either the caustic or the acid.
We prefer that the caustic cleaner be in the form of a highly caustic alkali foam that is dispensed from an aerosol can. The caustic foam is left on the surface long enough to do its job, generally about 20-30 minutes in the case of ovens. The concentration of caustic used as percent.free hydroxyl may be from about 5 percent to about percent or more, preferably about 7-8 percent. Any strong caustic alkali may be used, such as sodium hydroxide or potassium hydroxide or mixtures thereof. It may be in the form of a water solution, and it is preferable that a surfactant or combination of surfactants be employed to impart foaming characteristics. The surfactant may be either anionic or nonionic, including but not restricted to anionic surfactants such as alkyl aryl sulfonates,.alcohol or fatty acid sulfonates or ether sulfates, alkyl amide or ester sulfonates, and fatty acid glycerol ester sulfates or ether sulfonates; and nonionic surfactants such as ethoxylated alcohols and alkylphenols, alkyanolamides, and block copolymers of ethylene and propyleneglycol. In addition a suitable potassium or sodium soap may optionally be added and may consist of various combinations of tallow, cocoa, red oil, tall oil, stearic and oleic fatty acids. A small amount of hexylene or propylene glycol may be added as a solubilizer; and various other ingredients may be added for their known effects such as sodium carboxy methyl cellulose or starch as thickening agents to aid foam adherence to the surface, and water soluble silicones as foam boosters and soil releaseagents. An example of a preferred caustic foamcleaner to be dispensed from an aerosol container is:
Ingredient 94 by weight 45% Potassium hydroxide l9.l7 Stearic acid 0.5 Oleic acid 4.8 Hexylene glycol 4.0 Acid-base indicator 0.2 Water 7l.4
Preferably 90-60 percent proportion of the above preferred cleaner is added, to an aerosol container along with 4-10 percent of a liquefied propellant for example fluorocarbons such as Freon 12 or Freon 114 or mixtures thereof or known hydrocarbon propellants.
The neutralizer should be sufiiciently acidic to reduce the alkalinity of the caustic to a relatively safe level. Suitable active ingredients include any generally weak acid or acid salt, and the following are preferred: sodium dihydrogen phosphate, citric acid, hemi sodium phosphate, carbamide phosphoric acid, gluconic acid, ethylene diamine tetracetic acid, phosphoric acid, and any appropriate combinations thereof. Other acids such as dilute mineral acids may be used but generally in low concentration or very dilute form. The acid is preferably present in about 10 3 to l0"6 moles per liter hydrogen ion concentration; but this is widely variable since merely more of lower concentrations and less of higher concentrations will be used to substantially neutralize the caustic. An example of a preferred neutralizer to be dispensed from an aerosol container is:
It is preferred to add a defoamer to aid in the penetration of the acid or acid salt into the caustic foam. In the alternative the incorporation of a soap in the first stage aids in defoaming by the neutralizer acting to convert the soap to a fatty acid.
Suitable acid-base indicators include any that effect a color or change or color at a pH of between about 4 and about 1 l and include but are not restricted to phenolphthalein, thymolphthalein, brilliant yellow, thymol blue, cresol purple, neutral red, phenol red, bromthymol blue, chlorphenol red, methyl red, bromcresol green, and alizarine yellow. The acidbase indicator may be added to the first stage formulation, thereby visibly coloring the caustic foam i.e., phenolphthalein in about 0.2 percent by weight concentration will produce a red foam in the above described specific preferred caustic, thymolphthalein will produce blue, brilliant yellow will produce orange, and meta cresol purple will produce purple. After the caustic has been applied and allowed sufficient time to work, the second stage neutralizer would be sprayed on prior to wiping. The neutralizer renders the caustic safe and the safe level is indicated by a change in color of the foam. Thus when a caustic foam that includes phenolphthalein is sprayed on the surface to be cleaned a red color is developed. When the neutralizer is applied the color disappears as the foam is substantially neutralized. Thymolphthalein indicator would also turn colorless, brilliant yellow indicator would become yellow and meta cresol purple would also become yellow. Bromthymol blue will change from blue to yellow and neutral red from light brown to red.
Although the compositions of the present invention may be applied by brushing or daubing, they are preferably applied from two separate aerosol cans and/or spr'ay bottles. As a further alternative the two-formulations may be applied via separate nozzles of a compartmentalized aerosol or via separable bottle aerosol nozzle and propellant combinations, and like means.
Thisinvention is still further illustrated by specific examples, which are not to be construed as composition limitations upon the scope thereof.
EXAMPLE I .Exemplary caustic formulations were prepared as set forth in Table 1. Each of the formulations was added to an aerosol container, using about -96 percent of the formulation and about 4-l0 percent of a suitable propellant such as dichloro difluoromethane (Freon 12), tetrafluoro dichloro ethane (Freon 114), pentafluoro monochloro ethane (Freon 115), trifluoro trichloro ethane (Freon 113) cyclic hexafluoro dichloro butane (Freon C 316), octafluoropropane (Freon 218), cyclic octafluoro butane (Freon C 318), propane, butane, pentane, isobutane, hexane, eptane, octane, nonane and decane, or mixtures thereof.
A preferred acidic formulation was prepared as set forth hereinabove. It was packaged in a spray bottle and also in an aerosol can propelled with carbon dioxide, nitrogen, nitrous oxide or a combination of Freon 12, Freon l l and Freon l 14.
The examples set forth in Table l were sprayed upon standard soiled panels. The panels had vitreous porcelain surfaces and the soil resulted from deposits of general organic food constituents, including butter, that had been subjected to about 350F. heat for 30 minutes. All products formed good initial foams that were evaluated for stability and adhesion after a 20-minute period. The panels were then sprayed with the neutralizing formulation until a change in color was observed. The foams then broke and the substantially neutralized residues were wiped off the panels with a cloth. No burns or skin irritation occurred. Where heavy spots of soil deposit remained, the panel was treated a second time. All soil was removed.
TABLE I 3. The method of removing deposits of calcined food soils from surfaces, which comprises applying to said surfaces a highly caustic foam having about 5 percent or more of free hydroxyl and containing an amount of an acid-base indicator that will roduce a color change at a H of about 4 to about 11; and t en applying an aqueous acr no solution to substantially neutralize-the caustic foam to produce a change in color of said foam.
43113 m e t hod of removing deposits of calcined food soils Example, percent by weight of ingredient Ingredient:
50% potassium hydroxide Surfactant (expressed as fatty acid). Ilexylono or propylene glycol. Water Thymolphthalein Phenolphthalein.. Brilliant yellow... Meta cresol purple. Para-nitro phenol...
Methyl red Phenol red Carboxymethyl cellulose 0.2
Total 100. 0 100. 0 100. 0 100. 0 100. 0 100.0 100.0
Color of caustic foam Blue Red Orange.-- Purple.... Yellow Yellow Red. Initial foam stability G d Good. G d Good..... Good. Good Good. Foam Stability, minutes Good. Good. Goo Poor Poor Good. Foam adhesion, 20 minutes..... Fair,...... Poor Poor Poor Poor.. Poor Poor. Neutralized color Colorless.. Colorless.. Yellow.. Colorless.. ed. Yellow. pH range of color. 9.3- 8.0- 7. 4- 7.0- 6. 2 8.0 Change l0.5....... 9.8 9.0 5.0 4.4.... 6.4. Soil removal Good... Good..... Good..... ood- Good..... G d-.... Good.
1 Color slightly unstable.
1 All foams were substantially neutralized by spraying ona% phosphate.
While this invention has been described with respect to specific embodiments of the method of removing deposits of soils from surfaces, such is by way of illustration and not in limitation; and it is to be understood that variations and modifications thereof obvious to those skilled the art may be made without departing from the spirit or scope of this inventron.
What is claimed is: g l
1. The method of removing deposits of soil from surfaces which comprises applying to said surfaces a caustic alkali having about 5 percent or more of free hydroxyl, said caustic containing an acid-base indicator that changes color at a pH weak acid solution of either citric acid or sodium hydrogen from surfaces which comprises applying to said surfaces an alkaline material containing a caustic alkali having about 5 percent or more of free hydroxyl and an acid-base indicator that produces a color change at a pH of about 4 to about 1 l; and then applying an aqueous solution which is sufficiently acidic to substantially neutralize the alkaline material and to change the color of the alkaline material.
5. The method of claim 4 in which said acid-base indicator is selected from the group consisting of phenolphthalein, thymolphthalein, brilliant yellow, meta cresol purple, thymol blue, neutral red, phenol red, methyl red, paranitro phenol and bromthymol blue.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1572848 *||Aug 27, 1924||Feb 9, 1926||American Sheet & Tin Plate||Removal of oxids from ferrous metal|
|US1849535 *||Apr 19, 1929||Mar 15, 1932||Kohnstamm & Co Inc H||Laundry souring composition and method|
|US2034361 *||Mar 23, 1929||Mar 17, 1936||Sutton Roy C||Alkaline detergent powder and method of making the same|
|US2502881 *||Oct 17, 1945||Apr 4, 1950||Weston Parker Elizabeth||Household cleaning composition|
|US2994664 *||Feb 19, 1958||Aug 1, 1961||Nalco Chemical Co||Dry acid cleaning compositions|
|US3031408 *||Aug 7, 1959||Apr 24, 1962||B T Babbitt Inc||Aerosol oven cleanser|
|US3042621 *||Nov 1, 1957||Jul 3, 1962||Colgate Palmolive Co||Detergent composition|
|US3042622 *||Nov 1, 1957||Jul 3, 1962||Colgate Palmolive Co||Abrasive cleaning composition|
|US3511707 *||May 8, 1967||May 12, 1970||North American Detergent Corp||Method of cleaning a stone surface and composition therefor|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4006091 *||Mar 14, 1975||Feb 1, 1977||Amway Corporation||Plastic bottle storable oven cleaner|
|US4390465 *||Jun 22, 1981||Jun 28, 1983||Fremont Industries, Inc.||Containing alkaline builder, conditioner, and surfactants|
|US4683008 *||Jul 12, 1985||Jul 28, 1987||Sparkle Wash, Inc.||Method for cleaning hard surfaces|
|US4965063 *||Aug 2, 1988||Oct 23, 1990||Irene Casey||Cleaner and disinfectant with dye|
|US5154917 *||Sep 11, 1990||Oct 13, 1992||Beecham Inc.||Color change mouthrinse|
|US5223245 *||Aug 11, 1992||Jun 29, 1993||Beecham Inc.||Color change mouthrinse|
|US5482654 *||Nov 9, 1994||Jan 9, 1996||Warnaway Corporation||Safety indicator system|
|US5626685 *||May 24, 1994||May 6, 1997||Spindler; William E.||Method of removing a water insoluble surface coating from a surface|
|US5670469 *||Jan 6, 1995||Sep 23, 1997||Texas Research Institute||Nonionic and anionic surfactants with solvents, builders and colors|
|US5770222 *||Jun 7, 1995||Jun 23, 1998||Imarx Pharmaceutical Corp.||Therapeutic drug delivery systems|
|US5776429 *||Apr 30, 1996||Jul 7, 1998||Imarx Pharmaceutical Corp.||Method of preparing gas-filled microspheres using a lyophilized lipids|
|US5803795 *||Jul 12, 1996||Sep 8, 1998||Teisan Kabushiki Kaisha||Method of treating inner surface of high-pressure gas vessel|
|US5830430 *||Feb 21, 1995||Nov 3, 1998||Imarx Pharmaceutical Corp.||Cationic lipids and the use thereof|
|US5842815 *||Nov 21, 1996||Dec 1, 1998||Arthur Michael Rogers Howes||Chemical treatment of treading surfaces|
|US5846517 *||Jan 30, 1997||Dec 8, 1998||Imarx Pharmaceutical Corp.||Methods for diagnostic imaging using a renal contrast agent and a vasodilator|
|US5853752 *||Jun 6, 1995||Dec 29, 1998||Imarx Pharmaceutical Corp.||Methods of preparing gas and gaseous precursor-filled microspheres|
|US5922304 *||Mar 9, 1995||Jul 13, 1999||Imarx Pharmaceutical Corp.||Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents|
|US5935553 *||Nov 25, 1996||Aug 10, 1999||Imarx Pharmaceutical Corp.||Methods of preparing gas-filled liposomes|
|US5985246 *||Jul 8, 1997||Nov 16, 1999||Imarx Pharmaceutical Corp.||Contrast agents for ultrasonic imaging and methods for preparing the same|
|US5997898 *||Jun 6, 1995||Dec 7, 1999||Imarx Pharmaceutical Corp.||Stabilized compositions of a sf6 gas and a phosphorylated fluorinated amphiphilic compound, contrast agents for ultrasound.|
|US6001335 *||Jun 18, 1996||Dec 14, 1999||Imarx Pharmaceutical Corp.||Synthesizing a lipid vesicle having a gas encapsulated therein for ultrasonic imaging, by subjecting a solvent-free composition of a gaseous precursor and lipid in aqueous medium to a first pressure, then a second lower pressure|
|US6028066 *||Jul 2, 1997||Feb 22, 2000||Imarx Pharmaceutical Corp.||For delivering higher concentrations of bioactive agents to improve efficacy of the bioactive agents|
|US6033645 *||Jun 19, 1996||Mar 7, 2000||Unger; Evan C.||Methods for diagnostic imaging by regulating the administration rate of a contrast agent|
|US6033646 *||Feb 19, 1998||Mar 7, 2000||Imarx Pharmaceutical Corp.||Method of preparing fluorinated gas microspheres|
|US6056938 *||May 5, 1998||May 2, 2000||Imarx Pharaceutical Corp.||Cationic lipids and the use thereof|
|US6071494 *||Aug 28, 1998||Jun 6, 2000||Imarx Pharmaceutical Corp.||Lipid, protein or polymer and a gas or gaseous precursor, in combination with a renal vasodilator.|
|US6071495 *||Oct 2, 1997||Jun 6, 2000||Imarx Pharmaceutical Corp.||Targeted gas and gaseous precursor-filled liposomes|
|US6088613 *||Jun 7, 1995||Jul 11, 2000||Imarx Pharmaceutical Corp.||Method of magnetic resonance focused surgical and therapeutic ultrasound|
|US6090800 *||May 6, 1997||Jul 18, 2000||Imarx Pharmaceutical Corp.||Reaction product containing dexamethasone|
|US6117414 *||Nov 10, 1997||Sep 12, 2000||Imarx Pharmaceutical Corp.||Administering hydrophilic polymer covalently bonded to biocompatible lipid filled with perfluorocarbon of sulfur hexafluoride gas|
|US6120751 *||Sep 8, 1997||Sep 19, 2000||Imarx Pharmaceutical Corp.||Charged lipids and uses for the same|
|US6123923 *||Dec 18, 1997||Sep 26, 2000||Imarx Pharmaceutical Corp.||Optoacoustic contrast agents and methods for their use|
|US6139819 *||Sep 17, 1997||Oct 31, 2000||Imarx Pharmaceutical Corp.||Comprising lipid, protein, polymer and/or surfactant, and a gas, in combination with a targeting ligand; targeting ligand targets coagula, including emboli and/or thrombi, particularly in patients suffering from arrhythmic disorder|
|US6143276 *||Mar 21, 1997||Nov 7, 2000||Imarx Pharmaceutical Corp.||Methods for delivering bioactive agents to regions of elevated temperatures|
|US6146657 *||Nov 1, 1996||Nov 14, 2000||Imarx Pharmaceutical Corp.||Liposome filled with an insoluble gas and a soluble gas, wherein said liposome comprises phosphatidylcholine(s), phosphatidylethanolamine(s), and phosphatidic acid(s); use in ultrasonic or magnetic resonance imaging|
|US6156292 *||Dec 20, 1996||Dec 5, 2000||Sonus Pharmaceuticals, Inc.||Extremely small bubbles, or ?microbubbles,? comprised of octafluoropropane, dodecafluoropentane, or decafluorobutane.|
|US6231834||Dec 2, 1997||May 15, 2001||Imarx Pharmaceutical Corp.||Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same|
|US6245319||Mar 24, 2000||Jun 12, 2001||Sonus Pharmaceuticals, Inc.||Colloidal dispersions of perfluoropentane|
|US6315981||Mar 19, 1999||Nov 13, 2001||Imarx Therapeutics, Inc.||Used for obtaining image of an internal region of humans|
|US6391226||May 3, 1999||May 21, 2002||Laboratoires Choisy Ltee||Coating or sealing composition|
|US6403056||Mar 31, 2000||Jun 11, 2002||Imarx Therapeutics, Inc.||Administering agent; applying ultrasonic frequency|
|US6414139||Sep 3, 1996||Jul 2, 2002||Imarx Therapeutics, Inc.||Silicon amphiphilic compounds and the use thereof|
|US6416740||May 11, 1998||Jul 9, 2002||Bristol-Myers Squibb Medical Imaging, Inc.||Acoustically active drug delivery systems|
|US6443898||Jun 7, 1995||Sep 3, 2002||Imarx Pharmaceutical Corp.||Therapeutic delivery systems|
|US6444660||Feb 3, 2000||Sep 3, 2002||Imarx Therapeutics, Inc.||Dexamethasone covalently bonded to a lipid moiety via a linking group|
|US6461586||Jul 10, 2000||Oct 8, 2002||Imarx Therapeutics, Inc.||Method of magnetic resonance focused surgical and therapeutic ultrasound|
|US6479034||Jul 17, 1998||Nov 12, 2002||Bristol-Myers Squibb Medical Imaging, Inc.||Method of preparing gas and gaseous precursor-filled microspheres|
|US6521211||Feb 3, 1999||Feb 18, 2003||Bristol-Myers Squibb Medical Imaging, Inc.||Methods of imaging and treatment with targeted compositions|
|US6528039||Jun 18, 1997||Mar 4, 2003||Bristol-Myers Squibb Medical Imaging, Inc.||Low density microspheres and their use as contrast agents for computed tomography and in other applications|
|US6537246||Jun 18, 1997||Mar 25, 2003||Imarx Therapeutics, Inc.||Oxygen delivery agents and uses for the same|
|US6548047||Sep 15, 1997||Apr 15, 2003||Bristol-Myers Squibb Medical Imaging, Inc.||Thermal preactivation of gaseous precursor filled compositions|
|US6551576||Mar 31, 1998||Apr 22, 2003||Bristol-Myers Squibb Medical Imaging, Inc.||Container with multi-phase composition for use in diagnostic and therapeutic applications|
|US6576220||May 10, 2001||Jun 10, 2003||Imarx Therapeutics, Inc.||Non-invasive methods for surgery in the vasculature|
|US6585955||Oct 31, 1996||Jul 1, 2003||Bracco International B.V.||Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof|
|US6592846||May 12, 2000||Jul 15, 2003||Bracco International B.V.||Preventing collapse under pressure by filling with water insoluble perhalocarbon gas|
|US6613306||Sep 22, 1999||Sep 2, 2003||Bracco International B.V.||Ultrasound contrast agents and methods of making and using them|
|US6620404||Sep 28, 2000||Sep 16, 2003||Amersham Health A/S||Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media|
|US6638767||Dec 21, 2000||Oct 28, 2003||Imarx Pharmaceutical Corporation||Methods for delivering compounds into a cell|
|US6743779||Apr 29, 1997||Jun 1, 2004||Imarx Pharmaceutical Corp.||Methods for delivering compounds into a cell|
|US6773696||Oct 25, 2002||Aug 10, 2004||Bristol-Myers Squibb Medical Imaging, Inc.||Wherein void comprises vapor of volatile liquid (aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes, and perfluorocarbons); for computed tomography imaging of the gastrointestinal region|
|US6808720||Jan 15, 2002||Oct 26, 2004||Imarx Therapeutics, Inc.||Charged lipids and uses for the same|
|US6814816||Oct 3, 2003||Nov 9, 2004||Unilever Home & Personal Care Usa Division Of Conopco, Inc.||Using such as phenolphthalein and base to evaluate hand cleanliness without need of ultraviolet light|
|US6875420||Jul 18, 1997||Apr 5, 2005||Amersham Health As||Method of ultrasound imaging|
|US6881397||Feb 4, 2002||Apr 19, 2005||Bracco International B.V.||Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof|
|US6884407||May 18, 2000||Apr 26, 2005||Bristol-Myers Squibb Pharma Company||Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator|
|US6896875||Aug 23, 2002||May 24, 2005||Bracco International B.V.||Mixable combination for generating a suspension of stable microbubbles for ultrasonic imaging|
|US6989141||Apr 12, 2002||Jan 24, 2006||Bracco International B.V.||Administering contrast agent comprising stabilized microbubbles which comprises physiologically acceptable gas selected from freons, halogenated hydrocarbons, and fluorinated gases and surfactant; ultrasonically imaging|
|US6998107||Jun 10, 2004||Feb 14, 2006||Bristol-Myers Squibb Pharma Comapany||comprises void containing vapor of volatile liquid perfluorocarbon, combined with aqueous solution to form contrast agent, for oral/rectal administration or injection; for gastrointestinal imaging/tomography|
|US7078015||Nov 8, 2004||Jul 18, 2006||Imarx Therapeutics, Inc.||Temperature activated gaseous liposomes; therapy drug delivery; accumulating in cancer and disease tissue|
|US7083572||Mar 26, 2002||Aug 1, 2006||Bristol-Myers Squibb Medical Imaging, Inc.||Therapeutic delivery systems|
|US7083778||Mar 12, 2003||Aug 1, 2006||Bracco International B.V.||Ultrasound contrast agents and methods of making and using them|
|US7105151||Jan 6, 2003||Sep 12, 2006||Imarx Therapeutics, Inc.||Oxygen delivery agents and uses for the same|
|US7329402||Jan 13, 2003||Feb 12, 2008||Imarx Pharmaceutical Corp.||Methods of imaging and treatment|
|US7344705||Oct 18, 2005||Mar 18, 2008||Bristol-Myers Squibb Medical Imaging, Inc.||Composition comprising low density microspheres|
|US7452551||Oct 30, 2000||Nov 18, 2008||Imarx Therapeutics, Inc.||Administering to the patient a contrast agent comprising, in an aqueous carrier, targeted vesicles formulated from a lipid or polymer, a perfluorocarbon gas, a targeting ligand, scanning the patient using ultrasound to obtain an image|
|US7550422||Oct 4, 2005||Jun 23, 2009||The Procter & Gamble Company||for mask the reddish-brown water color after items are washed or rinsed in water; giving a color change when in contact with selected metal ions; to enhance the color of suds|
|US7612033||Mar 18, 2004||Nov 3, 2009||Imarx Pharmaceutical Corp.||administering to the cell a composition which comprises the compound to be delivered and an organic halide such as a perfluorocarbon; ultrasound|
|US7651989||Aug 29, 2003||Jan 26, 2010||Kimberly-Clark Worldwide, Inc.||A stable, single phase color changing toiletry or cleaning product that provide a time delayed indication that a predetermined cleaning interval has passed after dispensing; comprising a redox dye and a reducing agent, reagents sensitive to oxygen; children's hand washing; food prepartion|
|US7858568||Jan 22, 2010||Dec 28, 2010||Kimberly-Clark Worldwide, Inc.||A stable, single phase color changing toiletry or cleaning product that provide a time delayed indication that a predetermined cleaning interval has passed after dispensing; comprising a redox dye and a reducing agent, reagents sensitive to oxygen; children's hand washing; food prepartion|
|US7910531||Jun 13, 2005||Mar 22, 2011||C2C Technologies Llc||Composition and method for producing colored bubbles|
|US8012457||Jun 2, 2005||Sep 6, 2011||Acusphere, Inc.||Ultrasound contrast agent dosage formulation|
|US8067350||Apr 27, 2007||Nov 29, 2011||Kimberly-Clark Worldwide, Inc.||cleaning compouhnds comprising blends of surfactants, a thermochromic dye and suspending agent selected from clays, starches, modified cellulose, natural gums, fatty acid, fatty alcohol, colloidal or fumed particles, fatty esters, polyoxyethylene glycol ether or mixtures|
|US8084056||Sep 22, 2003||Dec 27, 2011||Lantheus Medical Imaging, Inc.||Useful as an ultrasonic contrast agent; making by dissolving a nonaqueous solvent in a lipid blend, then contacting the solution with an aqueous solution to form a lipid suspension|
|US8586005||Aug 6, 2007||Nov 19, 2013||Acusphere, Inc.||Ultrasound contrast agent dosage formulation|
|US8658205||Aug 1, 2011||Feb 25, 2014||Lantheus Medical Imaging, Inc.||Preparation of a lipid blend and a phospholipid suspension containing the lipid blend|
|US8685441||Jul 23, 2013||Apr 1, 2014||Lantheus Medical Imaging, Inc.||Preparation of a lipid blend and a phospholipid suspension containing the lipid blend|
|USRE39146||Jul 15, 1998||Jun 27, 2006||Bracco International B.V.||Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof|
|CN101035887B||Sep 30, 2005||Mar 9, 2011||宝洁公司||A composition with a metal-complexing dye and surfactant|
|WO1996020995A1 *||Jan 5, 1996||Jul 11, 1996||Alan Bray||Compositions containing a visible colorant and methods for cleaning and decontamination|
|WO2006041739A1 *||Sep 30, 2005||Apr 20, 2006||Procter & Gamble||A composition with a metal-complexing dye and surfactant|
|WO2008117233A1 *||Mar 25, 2008||Oct 2, 2008||Procter & Gamble||Liquid detergent composition system having a visual indication change|
|WO2008117235A1 *||Mar 25, 2008||Oct 2, 2008||Procter & Gamble||Liquid composition system having a visual indication change|
|WO2008141847A1 *||Feb 28, 2008||Nov 27, 2008||Unilever Plc||Triphenyl methane and xanthene pigments|
| || |
|U.S. Classification||134/27, 510/197, 134/40, 436/163|
|International Classification||C11D3/00, C11D7/06, C11D7/02, C11D3/40|
|Cooperative Classification||C11D3/40, C11D3/0057, C11D7/06|
|European Classification||C11D3/00B11, C11D7/06, C11D3/40|