|Publication number||US3682162 A|
|Publication date||Aug 8, 1972|
|Filing date||Dec 4, 1969|
|Priority date||Dec 13, 1968|
|Also published as||DE1961856A1|
|Publication number||US 3682162 A, US 3682162A, US-A-3682162, US3682162 A, US3682162A|
|Inventors||John E Colyer|
|Original Assignee||Wellcome Found|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (8), Non-Patent Citations (1), Referenced by (227), Classifications (22) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Combined electrode and hypodermic syringe needle
US 3682162 A
A hypodermic needle for connection with a hypodermic syringe attachment and which comprises at least two electrode elements, an inner one of which conveys fluid as a conventional hypodermic needle and the two of which combine as a probe having a tip-end stimulation zone when connected with an electrical supply.
United States Patent Colyer [4 1 Aug. 8, 1972 1541 COMBINED ELECTRODE AND HYPODERMIC SYRINGE NEEDLE Inventor: John E. Colyer, Longueville, New
South Wales, Australia Assignee: The Wellcome Foundation Limited,
London, England Filed: Dec. 4, 1969 Appl. No.: 882,314-
Foreign Application Priority. Data Dec. 13, 1968 Australia ..47787 U.S. Cl. ..l28/2.1 R, 128/303.l8, 128/221, 128/ 172.1, 128/404 Int. Cl. ..A61b 5/04, A61b 17/40 Field of Search .....128/2 .1 R, 2.1 E, 419 P, 214, 128/2.1 B, 214.4, 419 D, 404, 172.2, 172.1,
References Cited UNITED STATES PATENTS 4/1967 Chesebrough et a1...128/2.1 E
llllllililig Reiner ..128/2.1 E
3,087,486 4/1963 Kilpatrick ..128/2.1 E 3,078,850 2/ 1963 Schein et al. ..l28/2.1 E X 3,295,514 l/1967 Hein et a1 ..128/2.l E 2,516,882 8/1950 Kalom ..128/303.18 X 3,224,436 12/ 1965 be Massena ..l28/2.l E 3,568,660 3/ 1971 Crites et a1 ..2 R/
OTHER PUBLICATIONS lmpulses in Motor Nerve Fibers, Journal of Physiology, Volume 67 (1929), p. 133
I I Primary Examiner-Richard A. Gaudet 9 Assistant Examiner-J. C. McGowan Attorney-Holman & Stern ABSTRACT A hypodermic needle for connection with a hypodermic syringe attachment and which comprises at least two electrode elements, an inner one of which conveys fluid as a conventional hypodermic needle and the two of which combine as a probe having a tipend stimulation zone when connected with an electri cal supply.
8 Claims, 6 Drawing Figures PATENTEDAUS 8 m2 SHEET 1 BF 2 W fSas Atgrney PATENTEDAIIB 1 2 SHEET 2 OF 2 Attorney COMBINED ELECTRODE AND I-IYPODERMIC SYRINGE NEEDLE BACKGROUND OF THE INVENTION (or anaesthetist) locate the position of a sensory or motor nerve, which is disposed beneath the skin and tissue of a patient and that the nerve be identified (by the application of electrical stimulus) and, thereafter, be treated by the injection of a selected medicament.
I-Ieretofore, the steps of locating and identifying a particular nerve or tissue and, thereafter, of treating that nerve or tissue by injection have been performed as separate and independent functions.
- SUMMARY OF THE INVENTION The present invention however obviates such prior art techniques by providing a hypodermic needle consisting of at least two electrode elements which are separately connectable to an electrical supply, an inner one of said electrodes comprising a hollow tubular electrode which is connectable with a hypodermic syringe attachment and the outer one of said electrodes being a hollow tubular electrode which is electrically insulated from said inner electrode.
Further, separate electrodes may be located within the insulated space between the inner and outer electrodes and be separately connectable to, for example, electrical sensory-recording apparatus.
A needle in accordance with one embodiment of the present invention consists of two coaxial electrodes,
each being of stainless steel cylindrical tubing, and an inner one of which has a hub portion at its upper end for connection in the normal manner to a hypodermic syringe attachment. Thus, the inner electrode has the appearance of a more orless conventional hypodermic needle.
The outer electrode is spaced coaxially from the inner electrode and is permanently separated therefrom along its full length by a suitable insulating material. The outer electrode is also formed with a hub portion at its upper end.
The hub portions of the inner and outer electrodes are adapted to be separately connected through flexible leads with an electrical supply such as an electronic nerve locator/stimulator.
The lower end of both the electrodes terminates in a common bevelled plane (which constitutes the tip of the needle) and the area defined by the inner and outer electrodes at this tip constitutes a stimulation zone.
A portion of the length of the outer electrode, intermediate its hub and lower end, may be encapsulated in a molded sleeve of sterilizable thermosetting plastic material, whereby the needle may be conveniently held by an anaesthetist during manipulation and fitting of the syringe attachment. Such sleeve may extend to and partially encapsulate the hub portion of the needle and be apertured to define terminal socket portions for electrical connectors to the hubs.
The outer electrode, or the exposed lower end thereof, may be coated with a material having a low coefficient of friction, such as polytetrafluoroethylene (PTFE).
In use, the needle is connected with an electronic locator/stimulator and inserted into a patient, and, by adopting well known techniques, precise location and identification of a sensory nerve or motor nerve may be achieved. Having located and identified a particular nerve, a hypodermic syringe is attached to the needle (while the needle remains in the patient) and a medicament injected as required. Alternatively, location and identification of a particular nerve may be performed with the syringe preattached to the needle.
More specifically, the needle, when connected (through flexible leads) with the locator/stimulator device described in the above referenced co-pending application, is inserted into the patient to approximately half the anticipated depth of the nerve to be located from the surface. Thereafter, the output potential of the locator/stimulator is adjusted to approximately 10 volts, and the-needle is advanced closer to the anticipated position of the nerve. A single pulse output from the locator/stimulator is then initiated to test for response to stimulation.
Upon a response being produced in the patient, the voltage is then reduced below that point where no further response is demonstrated. The needle/ electrode is then re-advanced and further tests are made for response to single pulse stimulation. This procedure is repeated until such time as a response can be evoked with a voltage pulse of approximately 1 volt amplitude. At this point, the stimulating tip of the needle should be very close to the nerve to be, for example, blocked.
When the nerve has been located with adequate precision, a local anesthetic is injected through the needle/electrode (which has until this point been employed purely as a probe) until response to stimulation is no longer demonstrated.
The needle/electrode is retained in position while further stimulation and physical examination is employed to confirm that a satisfactory nerve block has been achieved. In the presence of a satisfactory block, motor response to stimulation usually can be demonstrated by applying a potential of approximately 10 volts to the located nerve.
The needle/electrode above defined has obvious advantages in assisting in the reduction of the dosage of local anesthetic or other chemical agents, thus minimizing the risks of drug reaction. Further advantages lie in being able to block nerves which are difficult to locate, particularly deep nerves or those subject to wide anatomical variation, and in blocking specific nerve branches or fiber groups without impairing adjacent fibers.
BRIEF DESCRIPTION OF THE DRAWINGS The invention will be more fully understood from the following description of preferred embodiments thereof taken in conjunction with the accompanying drawings wherein,
FIG. 1 represents an exploded assembly elevation view of needle/electrode, hypodermic syringe and electrical connectors for the needle/electrode,
FIG. 2 is a magnified view of the encircled end of the needle/electrode of FIG. 1,
FIG. 2A is a view, similar to that of FIG. 2, showing a modified form of the needle/electrode,
FIG. 3 is an enlarged elevation view, partly in section, of the needle/electrode of FIG. 1,
a FIG. 4 is a section of the needle/electrode taken along plane 4-4 of FIG. 3, and
FIG. 5 is an enlarged elevation view, partly in section, of a modified form of the needle/electrode.
DETAILED DESCRIPTION OF THE INVENTION With reference to FIG. 1, there is shown a needle/electrode denoted generally which is adapted to be secured in a conventional manner, by way of a Luer fitting, to lower end 11 of adispensing means, such as a hypodermic syringe attachment 12. The needle/electrode 10 comprises two electrodes, as hereinafter described, and U-shaped electrical connector clips 13 are connectable to the respective electrodes.
The connector clips 13 are, in turn, electrically connectable through a two-core flex 14 with output terminals 15 of a locator/stimulator apparatus 16.
The needle/electrode 10 does, as abovementioned, consist of two coaxial electrodes 17 and 18 with each being formed of stainless steel.
The inner electrode 17 has a hub portion 19 (Le, a
Luer fitting) at its upper end for connection to the syringe attachment 12 and a lower needle portion 20 having a smooth lumen 21. That is, the inner electrode 17 has the appearance of a conventional hypodermic needle.
The outer electrode 18 is spaced co-axially from the inner electrode 17 and the two electrodes are separated by a suitable insulating material 22. The suitability of the insulating material 22 is dependent upon its insulating properties over the low voltages employed and upon its ability to withstand sterilization temperatures or sterilizing chemicals. One material found suitable for the purpose is an epoxy resin.
The outer electrode is also formed with a hub portion 24 at its upper end which, as illustrated in FIGS. 1 and 3, is similar to the hub portion'19 of the inner electrode, and it has a lower needle portion 25 having a smooth outer surface. Thus the outer electrode 18 has also the appearance of a conventional hypodermic needie.
A permanent connection is made between the hub portions 19 and 2 4 of the respective electrodes by an epoxy resin or a thermosetting plastic material.
The needle portions 20 and 25 of the electrodes 17 and 18 terminate in a common bevelled plane, which constitutes the tip 26 of the needle, and the area defined by the inner and outer electrodes at the tip constitutes a stimulation zone.
As illustrated in part in FIG. 2A, additional fine wire electrodes 27 may be located in the space between the inner and outer electrodes 17 and 18. Such electrodes 27 may be separately electrically connectable, at a point (not shown) between the hub portions 19 and 24 of the inner and outer electrodes, to electrical sensoryrecording apparatus v(also not shown) by way of a m lti-core flex.
eferrmg now to FIG. 5 wherein the same reference numerals are employed to identify the like parts of the preceding figures, there is illustrated a needle/electrode which is in part encapsulated in a molded sleeve 28 of a sterilizable thermosetting plastic material. The sleeve 28 extends over a major portion of the hub portions 19 and 24 of the two electrodes and for approximately half the length of the outer needle 25.
Terminal apertures 29 are molded in the sleeve in alignment with contact sockets 30 in the respective hubs for reception of resilient contact pins (not shown).
With this arrangement the needle/electrode may be conveniently handled as a probe prior to fitting of the syringe attachment 12.
Variations and modifications may be made in the embodiments above described without departing from the scope of the appended claims.
What is claimed is:
1. A hypodermic needle comprising two hollow tubular electrodes, one electrode being disposed within the other, means electrically insulating the outer electrode from the innerelectrode, means disposed on one of the electrodes for attachment to a dispensing means, electrically conducting means on each electrode for connection to a power supply, and each electrode having a lower tip end, the tip ends of said electrodes terminating in a common plane.-
2. The hypodermic needle as claimed in claim 1 wherein said inner and outer electrodes are coaxial.
' 3. The hypodermic needle as claimed in claim 1 including at least one further electrode located within the insulating means between the inner and outer electrodes, and means electrically connecting the further electrode with an external apparatus.
4. The hypodermic needle as claimed in claim 3 wherein said further electrode comprises a fine wire electrode.
5. The hypodermic needle as claimed in claim 1 wherein the lower tip end of both the inner and outer electrodes terminates in a bevelled plane, with the inner and outer electrodes in said plane defining an intermediate stimulation zone.
6. The hypodermic needle as claimed in claim 1 wherein the inner and outer electrodes both terminate in upper respective hub portions, with the hub portion of the inner electrode fitting within that of the outer electrode.
7. The hypodermic needle as claimed in claim 1 including a molded sleeve of insulating material covering the needle over a portion of its length.
- 8. A hypodermic needle comprising two hollow tubular electrodes, one of said electrodes being disposed 7 within the other electrode in coaxial relationship,
means electrically insulating the outer electrode from the inner electrode, said inner electrode having an Disclaimer 3,682,162.J0lm E. Gal ar, Longueville, New South Wales, Australia. COM- L BINED ELECTRODE AND HYPODERMIC SYRINGE NEE- DLE. Patent dated Aug. 8, 1972. Disclaimer filed Apr. 20, 1978, by
the assignee, Buwoughs Wellcome U0. Hereby enters this disclaimer tov all claims of said patent.
[Ofiicz'al Gazette June 13, 7.978.]
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2516882 *||Jan 22, 1948||Aug 1, 1950||Lawrence Kalom||Electrical probe|
|US3060923 *||Jan 7, 1959||Oct 30, 1962||Teca Corp||Coaxial electrode structure and a method of fabricating same|
|US3078850 *||Aug 26, 1960||Feb 26, 1963||Imp Electronics Inc||Electrochemotherapeutic cardiac device|
|US3087486 *||Mar 5, 1959||Apr 30, 1963||Cenco Instr Corp||Cardiac electrode means|
|US3224436 *||Apr 10, 1961||Dec 21, 1965||Honeywell Regulator Co||Hypodermic apparatus for measuring hydrogen ion concentration of blood within a living body|
|US3295514 *||Jun 8, 1964||Jan 3, 1967||Dentists Supply Co||Electrical dental instrument assembly|
|US3313293 *||Jan 13, 1964||Apr 11, 1967||Hewlett Packard Co||Multi-electrode needle|
|US3568660 *||Nov 20, 1967||Mar 9, 1971||Battelle Development Corp||Pacemaker catheter|
|1|| *||Impulses in Motor Nerve Fibers, Journal of Physiology, Volume 67 (1929), p. 133|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3817241 *||Feb 16, 1972||Jun 18, 1974||Braun E||Disposable central venous catheter and method of use|
|US4207897 *||Jul 13, 1977||Jun 17, 1980||John W. Lloyd||Cryosurgical probe|
|US4237896 *||Aug 1, 1979||Dec 9, 1980||Australian Merino Wool Harvesting Limited||Immobilizing animals|
|US4294245 *||Mar 24, 1980||Oct 13, 1981||Stimtech, Inc.||Perioperative application of electronic pain control in combination with anesthetic agents|
|US4301802 *||Mar 17, 1980||Nov 24, 1981||Stanley Poler||Cauterizing tool for ophthalmological surgery|
|US4483338 *||Jun 12, 1981||Nov 20, 1984||Raychem Corporation||Bi-Polar electrocautery needle|
|US4508419 *||Sep 30, 1982||Apr 2, 1985||Anibal Galindo||Hypodermic needle connector|
|US4515168 *||Jul 22, 1983||May 7, 1985||Chester Martin H||Clamp-on nerve stimulator and locator|
|US4524770 *||Jan 25, 1983||Jun 25, 1985||Ahmad Orandi||Endoscope injection needle|
|US4545374 *||Sep 3, 1982||Oct 8, 1985||Jacobson Robert E||Method and instruments for performing a percutaneous lumbar diskectomy|
|US4548207 *||Nov 17, 1982||Oct 22, 1985||Mentor O & O, Inc.||Disposable coagulator|
|US4616660 *||Dec 10, 1984||Oct 14, 1986||Suncoast Medical Manufacturing, Inc.||Variable alternating current output nerve locator/stimulator|
|US4753244 *||Jul 16, 1987||Jun 28, 1988||Landymore Roderick W||Encapsulated microelectronic heart monitor|
|US4824433 *||Apr 5, 1984||Apr 25, 1989||Sterimed Gesellschaft Fur Medizinischen Bedarf Mbh||Puncturing and catheterizing device for the human or animal body|
|US4919129 *||Nov 30, 1987||Apr 24, 1990||Celebration Medical Products, Inc.||Extendable electrocautery surgery apparatus and method|
|US5092344 *||Nov 19, 1990||Mar 3, 1992||Lee Tzium Shou||Remote indicator for stimulator|
|US5161533 *||Sep 19, 1991||Nov 10, 1992||Xomed-Treace Inc.||Break-apart needle electrode system for monitoring facial EMG|
|US5188803 *||Dec 1, 1988||Feb 23, 1993||Abbott Laboratories||Device for preparing a medical sensor for use|
|US5284154 *||Oct 23, 1992||Feb 8, 1994||Brigham And Women's Hospital||Apparatus for locating a nerve and for protecting nerves from injury during surgery|
|US5306236 *||Feb 18, 1993||Apr 26, 1994||Vickers Plc||Needle electrode for use with hypodermic syringe attachment|
|US5366490 *||Dec 22, 1993||Nov 22, 1994||Vidamed, Inc.||Medical probe device and method|
|US5370675 *||Feb 2, 1993||Dec 6, 1994||Vidamed, Inc.||Medical probe device and method|
|US5385544 *||May 14, 1993||Jan 31, 1995||Vidamed, Inc.||BPH ablation method and apparatus|
|US5409453 *||Aug 19, 1993||Apr 25, 1995||Vidamed, Inc.||Steerable medical probe with stylets|
|US5421819 *||May 13, 1993||Jun 6, 1995||Vidamed, Inc.||Medical probe device|
|US5425751 *||Jul 30, 1993||Jun 20, 1995||Medtronic, Inc.||Method and apparatus for optimum positioning of a muscle stimulating implant|
|US5435805 *||May 13, 1993||Jul 25, 1995||Vidamed, Inc.||Medical probe device with optical viewing capability|
|US5456662 *||May 9, 1994||Oct 10, 1995||Edwards; Stuart D.||Method for reducing snoring by RF ablation of the uvula|
|US5470308 *||Nov 19, 1993||Nov 28, 1995||Vidamed, Inc.||Medical probe with biopsy stylet|
|US5470309 *||Jan 12, 1994||Nov 28, 1995||Vidamed, Inc.||Medical ablation apparatus utilizing a heated stylet|
|US5514131 *||Sep 23, 1994||May 7, 1996||David L. Douglass||Method for the ablation treatment of the uvula|
|US5542915 *||Jan 12, 1994||Aug 6, 1996||Vidamed, Inc.||Thermal mapping catheter with ultrasound probe|
|US5554110 *||Jan 12, 1994||Sep 10, 1996||Vidamed, Inc.||Medical ablation apparatus|
|US5556377 *||Dec 22, 1993||Sep 17, 1996||Vidamed, Inc.||Medical probe apparatus with laser and/or microwave monolithic integrated circuit probe|
|US5599294 *||Oct 7, 1994||Feb 4, 1997||Vidamed, Inc.||Microwave probe device and method|
|US5599295 *||Nov 8, 1995||Feb 4, 1997||Vidamed, Inc.||Medical probe apparatus with enhanced RF, resistance heating, and microwave ablation capabilities|
|US5607389 *||Nov 27, 1995||Mar 4, 1997||Vidamed, Inc.||Medical probe with biopsy stylet|
|US5630794 *||Sep 23, 1994||May 20, 1997||Vidamed, Inc.||Catheter tip and method of manufacturing|
|US5672153 *||Sep 26, 1994||Sep 30, 1997||Vidamed, Inc.||Medical probe device and method|
|US5720718 *||Jan 6, 1994||Feb 24, 1998||Vidamed, Inc.||Medical probe apparatus with enhanced RF, resistance heating, and microwave ablation capabilities|
|US5720719 *||Sep 26, 1994||Feb 24, 1998||Vidamed, Inc.||Ablative catheter with conformable body|
|US5775331 *||Jun 7, 1995||Jul 7, 1998||Brigham And Women's Hospital||Apparatus and method for locating a nerve|
|US5830151 *||Nov 26, 1997||Nov 3, 1998||Innovative Design Associates||Apparatus for locating and anesthetizing peripheral nerves a method therefor|
|US5853373 *||Aug 5, 1996||Dec 29, 1998||Becton, Dickinson And Company||Bi-level charge pulse apparatus to facilitate nerve location during peripheral nerve block procedures|
|US5895370 *||Jan 7, 1997||Apr 20, 1999||Vidamed, Inc.||Medical probe (with stylets) device|
|US5928159 *||Apr 23, 1997||Jul 27, 1999||Neothermia Corporation||Apparatus and method for characterization and treatment of tumors|
|US6022334 *||Apr 17, 1998||Feb 8, 2000||Vidamed, Inc.||Medical probe device with optic viewing capability|
|US6042572 *||Feb 17, 1999||Mar 28, 2000||Fowler; Glenda H.||Device and method for cleaning artificial body passageways formed between two openings by piercing|
|US6190370||Jul 24, 1998||Feb 20, 2001||Arrow International, Inc.||Devices, systems and methods for determining proper placement of epidural catheters|
|US6206847||Mar 17, 1999||Mar 27, 2001||Vidamed, Inc.||Medical probe device|
|US6298256||Sep 10, 1999||Oct 2, 2001||Frank-Egbert Meyer||Device and method for the location and catheterization of the surroundings of a nerve|
|US6306100||Dec 16, 1998||Oct 23, 2001||Richard L. Prass||Intraoperative neurophysiological monitoring system|
|US6325764 *||Nov 10, 1997||Dec 4, 2001||Becton, Dickinson And Company||Bi-level charge pulse apparatus to facilitate nerve location during peripheral nerve block procedures|
|US6356783 *||Nov 20, 1997||Mar 12, 2002||David R. Hubbard, Jr.||Multi-electrode and needle injection device for diagnosis and treatment of muscle injury and pain|
|US6371943 *||Jul 14, 1999||Apr 16, 2002||Epimed International, Inc.||Spring tip needle combination|
|US6434431||Jan 20, 2000||Aug 13, 2002||Medtronic, Inc.||Intramuscular medical electrical lead with fixation member|
|US6440118 *||May 11, 1999||Aug 27, 2002||Lawrence S. Burr||Device and method to sense body substance transition|
|US6464661||Mar 27, 2001||Oct 15, 2002||Vidamed, Inc.||Medical probe with stylets|
|US6466817||Jun 8, 2000||Oct 15, 2002||Nuvasive, Inc.||Nerve proximity and status detection system and method|
|US6500128||Jun 8, 2001||Dec 31, 2002||Nuvasive, Inc.||Nerve movement and status detection system and method|
|US6501976 *||Jun 12, 2001||Dec 31, 2002||Lifescan, Inc.||Percutaneous biological fluid sampling and analyte measurement devices and methods|
|US6508647 *||Aug 15, 2001||Jan 21, 2003||Kazunori Kusano||Paste formulation for dental use, a paste injector, and a system for detecting of paste filling|
|US6533732||Feb 1, 2001||Mar 18, 2003||William F. Urmey||Nerve stimulator needle guidance system|
|US6535759||Oct 20, 2000||Mar 18, 2003||Blue Torch Medical Technologies, Inc.||Method and device for locating and mapping nerves|
|US6564078||Jun 4, 1999||May 13, 2003||Nuvasive, Inc.||Nerve surveillance cannula systems|
|US6564079||Jul 27, 2000||May 13, 2003||Ckm Diagnostics, Inc.||Electrode array and skin attachment system for noninvasive nerve location and imaging device|
|US6609018||Jul 26, 2001||Aug 19, 2003||Ckm Diagnostics, Inc.||Electrode array and sensor attachment system for noninvasive nerve location and imaging device|
|US6678550 *||Dec 7, 2001||Jan 13, 2004||Myolink, Llc||Multi electrode and needle injection device for diagnosis and treatment of muscle injury and pain|
|US6730083 *||May 7, 2002||May 4, 2004||B. Braun Melsungen Ag||Puncture cannula|
|US6925333||May 20, 2002||Aug 2, 2005||Peter Krebs||Combination needle for peripheral nerve block|
|US6973346||Jul 2, 2002||Dec 6, 2005||Arrow International, Inc.||Instrument and method for delivery of anaesthetic drug|
|US7022098||Apr 10, 2002||Apr 4, 2006||Baxter International Inc.||Access disconnection systems and methods|
|US7079883||May 7, 2003||Jul 18, 2006||Nuvaslve, Inc.||Nerve surveillance cannulae systems|
|US7120487 *||Jul 18, 2003||Oct 10, 2006||Nelson David A||Catheter system and method for administering regional anesthesia to a patient|
|US7138088||Apr 10, 2002||Nov 21, 2006||Baxter International Inc.||Access disconnection system and methods|
|US7147615||Jun 22, 2001||Dec 12, 2006||Baxter International Inc.||Needle dislodgement detection|
|US7177677||Oct 16, 2002||Feb 13, 2007||Nuvasive, Inc.||Nerve proximity and status detection system and method|
|US7207949||May 25, 2005||Apr 24, 2007||Nuvasive, Inc.||Surgical access system and related methods|
|US7214197||Nov 6, 2001||May 8, 2007||Prass Richard L||Intraoperative neurophysiological monitoring system|
|US7245963||Mar 7, 2002||Jul 17, 2007||Advisys, Inc.||Electrode assembly for constant-current electroporation and use|
|US7283866||May 17, 2005||Oct 16, 2007||Hatch Ltd||Needle having multiple electrodes|
|US7310546||May 26, 2006||Dec 18, 2007||Prass Richard L||Artifact detection electrode|
|US7386341||May 20, 2003||Jun 10, 2008||Arrow International, Inc.||Instrument and method for delivery of anaesthetic drugs|
|US7470236||Nov 24, 2000||Dec 30, 2008||Nuvasive, Inc.||Electromyography system|
|US7522953||Mar 25, 2004||Apr 21, 2009||Nuvasive, Inc.||System and methods for performing surgical procedures and assessments|
|US7553307||Oct 15, 2005||Jun 30, 2009||Baxano, Inc.||Devices and methods for tissue modification|
|US7555343||Oct 15, 2005||Jun 30, 2009||Baxano, Inc.||Devices and methods for selective surgical removal of tissue|
|US7578819||Jul 13, 2006||Aug 25, 2009||Baxano, Inc.||Spinal access and neural localization|
|US7582058||Jun 26, 2003||Sep 1, 2009||Nuvasive, Inc.||Surgical access system and related methods|
|US7643884||Jan 31, 2005||Jan 5, 2010||Warsaw Orthopedic, Inc.||Electrically insulated surgical needle assembly|
|US7657308||Feb 18, 2005||Feb 2, 2010||Nuvasive, Inc.||System and methods for performing dynamic pedicle integrity assessments|
|US7664544||Apr 30, 2004||Feb 16, 2010||Nuvasive, Inc.||System and methods for performing percutaneous pedicle integrity assessments|
|US7664545||Jul 28, 2006||Feb 16, 2010||Vgx Pharmaceuticals, Inc.||Electrode assembly for constant-current electroporation and use|
|US7682328||Jan 16, 2006||Mar 23, 2010||Baxter International Inc.||Access disconnection systems and methods|
|US7691057||Jan 16, 2004||Apr 6, 2010||Nuvasive, Inc.||Surgical access system and related methods|
|US7693562||Oct 31, 2007||Apr 6, 2010||Nuvasive, Inc.||Nerve surveillance cannulae systems|
|US7713256||Apr 9, 2007||May 11, 2010||Becton, Dickinson And Company||System and method of delivering local anesthesia|
|US7713257||Apr 9, 2007||May 11, 2010||Becton, Dickinson And Company||System and method of delivering local anesthesia|
|US7738968||Oct 15, 2005||Jun 15, 2010||Baxano, Inc.||Devices and methods for selective surgical removal of tissue|
|US7738969||Jan 21, 2009||Jun 15, 2010||Baxano, Inc.||Devices and methods for selective surgical removal of tissue|
|US7740631||Oct 15, 2005||Jun 22, 2010||Baxano, Inc.||Devices and methods for tissue modification|
|US7785253||Jan 31, 2006||Aug 31, 2010||Nuvasive, Inc.||Surgical access system and related methods|
|US7819801||Feb 27, 2004||Oct 26, 2010||Nuvasive, Inc.||Surgical access system and related methods|
|US7857813||Aug 29, 2006||Dec 28, 2010||Baxano, Inc.||Tissue access guidewire system and method|
|US7887538||Mar 13, 2006||Feb 15, 2011||Baxano, Inc.||Methods and apparatus for tissue modification|
|US7892173||Dec 7, 2009||Feb 22, 2011||Nuvasive, Inc.||Surgical access system and related methods|
|US7905840||Oct 18, 2004||Mar 15, 2011||Nuvasive, Inc.||Surgical access system and related methods|
|US7918849||Oct 15, 2005||Apr 5, 2011||Baxano, Inc.||Devices and methods for tissue access|
|US7920922||Feb 24, 2010||Apr 5, 2011||Nuvasive, Inc.||System and methods for determining nerve proximity, direction, and pathology during surgery|
|US7922958||Jun 30, 2010||Apr 12, 2011||Becton, Dickinson And Company||Method of making an elongate syringe barrel|
|US7927281||Oct 8, 2008||Apr 19, 2011||Jay Wheeler||Automated needle pen drug delivery system|
|US7935051||Apr 22, 2009||May 3, 2011||Nuvasive, Inc.||Surgical access system and related methods|
|US7938830||Apr 17, 2006||May 10, 2011||Baxano, Inc.||Powered tissue modification devices and methods|
|US7959577||Mar 31, 2008||Jun 14, 2011||Baxano, Inc.||Method, system, and apparatus for neural localization|
|US7959594||Jan 25, 2006||Jun 14, 2011||Baxter International Inc.||Access disconnection systems and methods|
|US7962191||Oct 31, 2007||Jun 14, 2011||Nuvasive, Inc.||Nerve surveillance cannulae systems|
|US7963915||Oct 15, 2005||Jun 21, 2011||Baxano, Inc.||Devices and methods for tissue access|
|US7963927||Apr 21, 2004||Jun 21, 2011||Nuvasive, Inc.||Electromyography system|
|US7987001||Jan 25, 2007||Jul 26, 2011||Warsaw Orthopedic, Inc.||Surgical navigational and neuromonitoring instrument|
|US8000782||Dec 1, 2009||Aug 16, 2011||Nuvasive, Inc.||System and methods for performing surgical procedures and assessments|
|US8005535||Apr 14, 2009||Aug 23, 2011||Nuvasive, Inc.||System and methods for performing surgical procedures and assessments|
|US8016767||Apr 23, 2007||Sep 13, 2011||Nuvasive, Inc.||Surgical access system and related methods|
|US8027716||Apr 20, 2009||Sep 27, 2011||Nuvasive, Inc.||System and methods for performing surgical procedures and assessments|
|US8048080||May 4, 2006||Nov 1, 2011||Baxano, Inc.||Flexible tissue rasp|
|US8050769||May 1, 2009||Nov 1, 2011||Nuvasive, Inc.||System and methods for determining nerve proximity, direction, and pathology during surgery|
|US8062298||Mar 16, 2007||Nov 22, 2011||Baxano, Inc.||Flexible tissue removal devices and methods|
|US8062300||Mar 16, 2007||Nov 22, 2011||Baxano, Inc.||Tissue removal with at least partially flexible devices|
|US8068912||Jan 9, 2004||Nov 29, 2011||Nuvasive, Inc.||System and methods for determining nerve proximity, direction, and pathology during surgery|
|US8088119||Aug 14, 2007||Jan 3, 2012||Laurimed, Llc||Methods and devices for treating tissue|
|US8090436||Oct 29, 2009||Jan 3, 2012||Nuvasive, Inc.||Tissue discrimination and applications in medical procedures|
|US8092455||Feb 7, 2005||Jan 10, 2012||Warsaw Orthopedic, Inc.||Device and method for operating a tool relative to bone tissue and detecting neural elements|
|US8092456||Jan 13, 2009||Jan 10, 2012||Baxano, Inc.||Multiple pathways for spinal nerve root decompression from a single access point|
|US8114019||Dec 30, 2009||Feb 14, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8114043||Jul 25, 2008||Feb 14, 2012||Baxter International Inc.||Electromagnetic induction access disconnect sensor|
|US8133173||Dec 30, 2009||Mar 13, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8137284||Oct 8, 2003||Mar 20, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8137300||Mar 19, 2010||Mar 20, 2012||Baxter International Inc.||Access disconnection systems and methods using conductive contacts|
|US8147421||Jul 15, 2005||Apr 3, 2012||Nuvasive, Inc.||System and methods for determining nerve direction to a surgical instrument|
|US8165653||Jun 14, 2011||Apr 24, 2012||Nuvasive, Inc.||Surgical access and nerve surveillance|
|US8172750||Mar 17, 2010||May 8, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8182423||Dec 30, 2009||May 22, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8185205||Oct 22, 2007||May 22, 2012||B. Braun Medical Inc.||Catheter switch and method of using a catheter switch in administering a nerve or plexus block|
|US8187179||Dec 30, 2009||May 29, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8192356||Dec 10, 2009||Jun 5, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8192357||Dec 30, 2009||Jun 5, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8192435||Oct 15, 2005||Jun 5, 2012||Baxano, Inc.||Devices and methods for tissue modification|
|US8192436||Nov 26, 2008||Jun 5, 2012||Baxano, Inc.||Tissue modification devices|
|US8206312||Sep 22, 2006||Jun 26, 2012||Nuvasive, Inc.||Multi-channel stimulation threshold detection algorithm for use in neurophysiology monitoring|
|US8209006||Sep 8, 2003||Jun 26, 2012||Vgx Pharmaceuticals, Inc.||Constant current electroporation device and methods of use|
|US8221397||Apr 22, 2009||Jul 17, 2012||Baxano, Inc.||Devices and methods for tissue modification|
|US8244343||Aug 23, 2011||Aug 14, 2012||Nuvasive, Inc.||System and methods for performing surgical procedures and assessments|
|US8255035 *||Dec 31, 2007||Aug 28, 2012||St. Jude Medical, Atrial Fibrillation Division, Inc.||Coated hypodermic needle|
|US8255044||Feb 2, 2010||Aug 28, 2012||Nuvasive, Inc.||System and methods for performing dynamic pedicle integrity assessments|
|US8255045 *||Apr 3, 2008||Aug 28, 2012||Nuvasive, Inc.||Neurophysiologic monitoring system|
|US8257356||May 27, 2008||Sep 4, 2012||Baxano, Inc.||Guidewire exchange systems to treat spinal stenosis|
|US8265744||Aug 16, 2011||Sep 11, 2012||Nuvasive, Inc.||Systems and methods for performing surgical procedures and assessments|
|US8277437||Apr 2, 2009||Oct 2, 2012||Laurimed, Llc||Method of accessing two lateral recesses|
|US8287597||Apr 16, 2010||Oct 16, 2012||Nuvasive, Inc.||Method and apparatus for performing spine surgery|
|US8292909||Jul 16, 2012||Oct 23, 2012||Laurimed, Llc||Devices and methods for cutting tissue|
|US8298254||Jun 30, 2011||Oct 30, 2012||Laurimed, Llc||Devices and methods for cutting and evacuating tissue|
|US8303498||Feb 18, 2011||Nov 6, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8303515||Dec 11, 2009||Nov 6, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8303516||Apr 20, 2011||Nov 6, 2012||Baxano, Inc.||Method, system and apparatus for neural localization|
|US8313430||Jan 11, 2007||Nov 20, 2012||Nuvasive, Inc.||Surgical access system and related methods|
|US8328851||Jul 28, 2006||Dec 11, 2012||Nuvasive, Inc.||Total disc replacement system and related methods|
|US8343046||Mar 12, 2012||Jan 1, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8355780||Nov 20, 2009||Jan 15, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8361037 *||Sep 19, 2002||Jan 29, 2013||Valeritas, Inc.||Microneedles, microneedle arrays, and systems and methods relating to same|
|US8366712||Dec 6, 2011||Feb 5, 2013||Baxano, Inc.||Multiple pathways for spinal nerve root decompression from a single access point|
|US8374673||Jan 25, 2007||Feb 12, 2013||Warsaw Orthopedic, Inc.||Integrated surgical navigational and neuromonitoring system having automated surgical assistance and control|
|US8388527||Dec 31, 2009||Mar 5, 2013||Nuvasive, Inc.||Surgical access system and related method|
|US8394102||Jun 25, 2010||Mar 12, 2013||Baxano, Inc.||Surgical tools for treatment of spinal stenosis|
|US8398641||Dec 27, 2011||Mar 19, 2013||Baxano, Inc.||Tissue modification devices and methods|
|US8403841||Dec 14, 2009||Mar 26, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8409206||May 4, 2010||Apr 2, 2013||Baxano, Inc.||Tissue modification devices and methods|
|US8414587||Aug 31, 2007||Apr 9, 2013||Laurimed, Llc||Styli used to position device for carrying out selective discetomy|
|US8419653||Jul 16, 2009||Apr 16, 2013||Baxano, Inc.||Spinal access and neural localization|
|US8425430||Dec 10, 2009||Apr 23, 2013||Warsaw Orthopedic, Inc.||Electrically insulated surgical needle assembly|
|US8430881||Apr 17, 2006||Apr 30, 2013||Baxano, Inc.||Mechanical tissue modification devices and methods|
|US8439832||Jan 4, 2011||May 14, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8500634||Jan 17, 2013||Aug 6, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8500653||Jun 26, 2012||Aug 6, 2013||Nuvasive, Inc.||Neurophysiology monitoring system configured for rapid stimulation threshold acquisition|
|US8512235||Jun 1, 2012||Aug 20, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8523768||May 8, 2012||Sep 3, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8529490||Jun 9, 2011||Sep 10, 2013||Baxter International Inc.||Systems and methods for dialysis access disconnection|
|US8548579||Aug 7, 2012||Oct 1, 2013||Nuvasive, Inc.||System and methods for performing surgical procedures and assessments|
|US8550994||Nov 5, 2012||Oct 8, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8551097||Nov 1, 2010||Oct 8, 2013||Baxano Surgical, Inc.||Tissue access guidewire system and method|
|US8556808||Jan 15, 2013||Oct 15, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8562521||Feb 1, 2013||Oct 22, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8562539||Aug 21, 2007||Oct 22, 2013||Nuvasive, Inc.||Electromyography system|
|US8568317||Sep 27, 2006||Oct 29, 2013||Nuvasive, Inc.||System and methods for nerve monitoring|
|US8568331||Feb 2, 2006||Oct 29, 2013||Nuvasive, Inc.||System and methods for monitoring during anterior surgery|
|US8568416||Aug 17, 2012||Oct 29, 2013||Baxano Surgical, Inc.||Access and tissue modification systems and methods|
|US8579902||Mar 26, 2012||Nov 12, 2013||Baxano Signal, Inc.||Devices and methods for tissue modification|
|US8585704||Oct 6, 2011||Nov 19, 2013||Baxano Surgical, Inc.||Flexible tissue removal devices and methods|
|US8591432||Jan 3, 2011||Nov 26, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8591472 *||Jul 22, 2011||Nov 26, 2013||Ceramatec, Inc.||Apparatus for administering a therapeutic agent into tissue using a needle as the material treatment module|
|US8602982||Apr 4, 2013||Dec 10, 2013||Nuvasive, Inc.||Surgical access system and related methods|
|US8611993||Mar 8, 2005||Dec 17, 2013||Arrow International, Inc.||Pre-loaded lockable stimulating catheter for delivery of anaesthetic drugs|
|US8613745||May 20, 2011||Dec 24, 2013||Baxano Surgical, Inc.||Methods, systems and devices for carpal tunnel release|
|US8617163||May 20, 2011||Dec 31, 2013||Baxano Surgical, Inc.||Methods, systems and devices for carpal tunnel release|
|US8628469||Jul 30, 2013||Jan 14, 2014||Nuvasive, Inc.||Surgical access system and related methods|
|US8632486||Jan 4, 2012||Jan 21, 2014||Baxter International Inc.||Electromagnetic induction access disconnect systems|
|US8634904||Nov 8, 2011||Jan 21, 2014||Nuvasive, Inc.||System and methods for determining nerve proximity, direction, and pathology during surgery|
|US20100268054 *||Apr 20, 2010||Oct 21, 2010||Med-El Elektromedizinische Geraete Gmbh||Electrode Configuration and Measuring Device for Measuring the Electrical Activity in Electrically Active Tissue|
|US20110190763 *||Jan 29, 2010||Aug 4, 2011||Medtronic, Inc.||Needle Design for Recording Monophasic Action Potential and Delivery of Therapy|
|US20120022438 *||Jul 22, 2011||Jan 26, 2012||Joshi Ashok V||Apparatus for administering a therapeutic agent into tissue using a needle as the material treatment moduel|
|US20120150173 *||Feb 15, 2012||Jun 14, 2012||Joshi Ashok V||Method for in situ treatment of a tissue|
|US20130237795 *||Mar 9, 2012||Sep 12, 2013||Carefusion 2200, Inc.||Performance concentric electromyography needle|
|USRE31866 *||Dec 8, 1982||Apr 16, 1985||Australian Merino Wool Harvesting Ltd.||Immobilizing animals|
|CN100581608C||Feb 28, 2005||Jan 20, 2010||刘志成;纪树荣;刘建军||Located therapeutic syringe needle utilizing electricity to stimulate spastic motion point|
|DE2732486A1 *||Jul 19, 1977||Jan 26, 1978||Spembly Ltd||Kaeltechirurgisches geraet|
|DE2926744A1 *||Jul 3, 1979||Jan 8, 1981||Rainer Ing Grad Koch||Thermosonde mit integriertem vorverstaerker in multichiptechnik und elektronisch ausfahrbarer mikroelektrode zur einzelzellableitung und einzelzellreizung waehrend stereotaktischer hirneingriffe|
|EP0067680A1 *||Jun 11, 1982||Dec 22, 1982||RAYCHEM CORPORATION (a California corporation)||Electrocautery needle and method of forming it|
|EP0102538A1 *||Aug 5, 1983||Mar 14, 1984||Sterimed Gesellschaft für medizinischen Bedarf mbH||Device for puncture and catheterisation for human or animal bodies|
|EP0823239A2 *||Aug 5, 1997||Feb 11, 1998||Becton Dickinson and Company||Bi-level charge pulse apparatus to facilitate nerve location during peropheral nerve block procedures|
|EP0823265A2 *||Aug 5, 1997||Feb 11, 1998||Becton Dickinson and Company||Needle assembly for electrostimulation of a nerve|
|EP0959761A1 *||Nov 20, 1997||Dec 1, 1999||Myotech||Multi-electrode and needle injection device for diagnosis and treatment of muscle injury and pain|
|EP1260186A1 *||May 18, 2002||Nov 27, 2002||Peter Dr. Krebs||Needle assembly for blocking peripheral nerves|
|EP2097125A1 *||Dec 19, 2007||Sep 9, 2009||Ceramatec, Inc.||Apparatus and method for treating and dispensing a material into tissue|
|WO1980002231A1 *||Apr 24, 1980||Oct 30, 1980||Brownlee R||Long-life flexible electrode lead|
|WO1993020751A1 *||Apr 14, 1993||Oct 28, 1993||Brigham & Womens Hospital||Method and apparatus for locating a nerve|
|WO1996032156A1 *||Apr 10, 1996||Oct 17, 1996||St Luke S Roosevelt Hospital||Peripheral nerve stimulation device for unassisted nerve blockade|
|WO1996039932A1||May 31, 1996||Dec 19, 1996||Uromed Corp||Apparatus and method for locating a nerve|
|WO2003004093A2 *||Jul 5, 2002||Jan 16, 2003||Naja Mohamed Zouheir||Equipment for treating painful points in the organism|
|WO2006065818A1 *||Dec 12, 2005||Jun 22, 2006||Medex Inc||Bodily fluid space entry detection|
| || |
|U.S. Classification||600/373, 604/272, 604/239, 600/554|
|International Classification||A61N1/34, A61B5/0492, A61B5/042, A61B5/0478, A61N1/05, A61M5/42, A61M5/32|
|Cooperative Classification||A61B5/042, A61N1/0502, A61M5/427, A61N1/36021, A61M5/32, A61N1/36017|
|European Classification||A61N1/05A, A61N1/36E4, A61B5/042, A61M5/32, A61M5/42D|