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Publication numberUS3688763 A
Publication typeGrant
Publication dateSep 5, 1972
Filing dateJul 15, 1970
Priority dateJul 28, 1969
Publication numberUS 3688763 A, US 3688763A, US-A-3688763, US3688763 A, US3688763A
InventorsCromarty Raymond
Original AssigneeCromarty Raymond
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Diagnostic device and method
US 3688763 A
Abstract
Cellular material is collected from the large intestine of a patient on a sponge. The patient swallows the sponge contained compressed in a gelatin casing with an enteric coating, the casing being dissolved in the large intestine to release the sponge, which is naturally evacuated by the patient and recovered for analysis.
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Description  (OCR text may contain errors)

O United States Patent 51 3,688,763

Cromarty Sept. 5, 1972 [54] DIAGNOSTIC DEVICE AND METHOD 2,798,024 7/1957 Zapapas et al ..424/21 In entor: C marty Parmalea I Enz et a1 Crescent Weston Ontario Canada 3,315,660 4/1967 Abella ..128/2 F I 3,118,439 1/ 1964 Perrenoud 128/2 F [22] Filed: July 15, 1970 1,438,064 12/1922 Simmons ..128/260 471,343 3/1892 Poehl ..128/260 X [21] APPL R24,666 7/1959 Draghi ..12s/2 w 298,720 5/1884 Anderson ..128/269 X [30] Foreign Application Priority Data Primary Examinerl(yle L. Howell July 28, 1969 Great Britain ..37,84l/69 Att0mey Maybee & Legris [52] US. Cl. .JZB/Z B, 128/2 F, l28/2 W 57 ABSTRACT [51] Int. Cl. ..A6lb 10/00 [58] Field of Search 128/2 w 2 B, 2 F 2 p 2 R, Cellular material 18 collected from the large intestine 2 72 213 2 0 2 1 2 9. 424/ 9 22 Of a patient on a sponge. Tl'1 patient swallows the sponge contained compressed in a gelatin casing with [56] References Ciud an enteric coating, the casing being dissolved in the large intestine to release the sponge, which is naturally UNITED STATES PATENTS evacuated by the patient and recovered for analysis.

1,575,123 3/ 1926 Martocci-Pisculli...128l285 X 4 Claims, 1 Drawing Figure PATENTEDSEP 51912 3688.763

l NW-"EN'H R RAYMOND CROMARTY Attorneys DIAGNOSTIC DEVICE AND METHOD BACKGROUND OF THE INVENTION This invention relates to a diagnostic method for the detection of diseases and to a diagnostic device. More particularly, it relates to a method of and device for obtaining cellular material from the large intestine of a patient, for subsequent cytological examination.

BRIEF DESCRIPTION OF THE PRIOR ART It has previously been proposed to collect cells from the large intestine of a patient, for subsequent analysis, by injecting the patient anally with a polymerizable liquid composition. The composition polymerizes in situ in the body cavity to form a cellular, sponge-like mass, upon which cells from the body cavity deposit. The sponge-like mass is evacuated by the normal defecatory process of the patient, recovered, and the cells deposited thereon, removed and analyzed.

Such a procedure has the disadvantage that it requires expensive composition and equipment, and has to be carried out by skilled, medically trained personnel. It cannot be conducted by the patient himself, away from medical facilities.

SUMMARY OF THE INVENTION An object of the present invention is to provide a novel method of collecting cellular material from the large intestine of a patient, and a device therefor.

A further object is to provide a simple such method which can be conducted by the patient himself, and involves the use of an inexpensive device only.

According to one aspect of the present invention, there is provided a method of collecting cellular material from the large intestine of a patient, which comprises administering orally to the patient a capsule comprising a readily compressible sponge of fine pore structure enclosed in a gelatin or similar enzymedegradable casing, the casing having an enteric coating over its outer surface, recoveringthe sponge after its natural evacuation from the body, and recovering from the sponge cells collected thereon during its passage through the large intestine of the body.

According to a second aspect of the invention, there is provided a diagnostic device of an overall size such as to allow it to be swallowed by a patient and passed through the intestines of the body, said device comprising a sponge retained in compressed form inside a capsule, the capsule being insoluble in gastric juices of the stomach, but soluble to release the sponge in the large intestine.

BRIEF DESCRIPTION OF THE DRAWING The accompanying drawing shows an exploded view of a preferred embodiment of a diagnostic device according to the present invention.

The device is in the form of a capsule having two interfitting half shells l and 11, of circular cross section, of gelatin. Inside the shells of gelatin is provided a sponge 12. The sponge is compressed inside the shells, from a relaxed diameter of about 1 inch, to a diameter of about one-fourth inch, which is the approximate inner diameter of the gelatin shells.

After insertion of the sponge 12, the interfitting of the two half shells l0 and 11 to make a capsule, the

capsule is provided with an overall exterior enteric coating 13, which seals the capsule. The capsule is then ready to be administered to the patient. lts overall size is suitably three-fourths inch in length and one-fourth inch in diameter.

DESCRIPTION OF PREFERRED EMBODIMENTS The type of sponge is chosen with a view to easy compressibility, and very small adherence in relation to the walls of the intestines of the body. It must also, of course, be inert to the action of fluids present in the intestines, to which it will be exposed during use. Finely porous polyurethane sponge is suitable.

Suitable enteric coatings are those based on cellulose acetate phthalate. The coating may be applied in solvent form, for example as a solution in methylene chloride. The coating may also include additional ingredients such as plasticizers, e.g. ethyl phthalate, and non-friction aids, such as silicones.

In use, the capsule is swallowed by the patient, and passes into the stomach. Due to the presence of the enteric coating, the capsule remains unchanged and unaffected in the stomach, and passes into the small intestine. The secretions present in the small intestine start to attack the enteric coating and dissolve it. The gelatin shells are then attached by these secretions. Thus the capsule is disintegrated and the sponge released in the small intestine. The sponge is propelled along the intestines by the normal peristaltic action of the intestines, and eventually enters the large intestine. Here, the re-expanded sponge absorbs mucous, containing cells from the large intestine. The sponge travels on as before and is eventually naturally expelled from the anus, where it is carefully collected and the cells it has picked up removed and analyzed.

Preferably, the capsule is administered to the patient after a laxative, to clear the intestines of fecal material, and after several hours have elapsed since the patient consumed food. Further food should not be taken by the patient within about 7 hours after swallowing the capsule. This is to ensure that the sponge, when recovered,-is not contaminated with excessive amounts of fecal material, hindering analysis of the cells it has collected. The time from swallowing to emission of the sponge in the process of the present invention is normally about 12 hours.

By means of this invention, the presence of malignant cells in the large intestines can be determined, allowing early detection of pathological process of this organ.

What I claim as my invention is:

l. A method of collecting cellular material from the large intestine of a patient, which comprises fasting the patient, administering orally to the patient a capsule comprising an enzyme degradable casing, an enteric coating over the outer surface of said casing, and a readily compressible sponge of fine pore structure enclosed within said casing, recovering the sponge material after its natural evacuation from the body, and recovering from the sponge cells collected thereon during its passage through the large intestine of the body.

2. The method of claim 1 wherein the sponge is finely porous polyurethane sponge, and the casing is of gelatine.

4. A diagnostic device of an overall size such as to allow it to be swallowed by a patient and passed through the intestines of the body, said device being generally cylindrical in overall shape and comprising an enzyme degradable gelatine casing, a cellulose acetate phthalate based enteric coating over the outer surface of said casing, and a readily compressible and re-expandable finely porous polyurethane sponge retained and enclosed within said casing in a compressed form.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US24666 *Jul 5, 1859 Improvement in revolving fire-arms
US298720 *Feb 14, 1884May 20, 1884 Capsule
US471343 *Sep 30, 1889Mar 22, 1892 Alexander poehl
US1438064 *Nov 16, 1921Dec 5, 1922Johnson & JohnsonDental pellet
US1575123 *Aug 1, 1922Mar 2, 1926Leon Martocci-PisculliMedical appliance
US2798024 *Jun 2, 1954Jul 2, 1957Lilly Co EliComposite enteric tablet of erythromycin and sulfonamides
US3081233 *Aug 8, 1960Mar 12, 1963Upjohn CoEnteric-coated pilules
US3118439 *Mar 19, 1958Jan 21, 1964Jean-Pierre PerrenoudDiagnostic and medicating capsule and the method of use
US3315660 *Aug 8, 1963Apr 25, 1967Abella Carlos ACapsule for insertion in the digestive track
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3877464 *Aug 17, 1973Apr 15, 1975Vermes Andrew RIntra-uterine biopsy apparatus
US3998211 *Dec 20, 1974Dec 21, 1976Louis BucaloStructures for growing cultures within human and animal bodies
US4172446 *Dec 30, 1975Oct 30, 1979Louis BucaloApparatus for collecting body fluids
US4186730 *Dec 2, 1976Feb 5, 1980Louis BucaloMethods for collecting body fluids
US4257427 *Sep 13, 1979Mar 24, 1981Louis BucaloMethod for collecting body fluids
US4735214 *Sep 5, 1986Apr 5, 1988Berman Irwin RGastrointestinal diagnostic capsule and method of use
US4774962 *Sep 23, 1986Oct 4, 1988Walter Sarstedt Kunststoff-SpritzgusswerkMethod of extracting human saliva
US4817632 *Jun 23, 1987Apr 4, 1989Bioquant, Inc.Oral fluid collection article
US4979947 *Oct 10, 1985Dec 25, 1990Berman Irwin REncapsulated expandible continence device
US5113871 *Jul 8, 1988May 19, 1992Jouko ViljantoDevice for the determination of incisional wound healing ability
US5231992 *Dec 10, 1991Aug 3, 1993Leon Arnaldo CLow-impact cervical cell and fluid collector
US5576020 *Apr 14, 1995Nov 19, 1996Kanegafuchi Kagaku Kogyo Kabushiki KaishaPolyester coating material for use in large intestine-selective drug release pharmaceutical preparations
US5603950 *Nov 7, 1994Feb 18, 1997Ratjen; WernerDecreasing appetite by promoting temporary fullness with a soluble capsule having expandable wheat fiber inside; dietetics
US5644012 *Nov 16, 1992Jul 1, 1997Kanegafuchi Kagaku Kogyo Kabushiki KaishaAdjuvant for pharmaceutical preparations
US5854368 *Dec 30, 1996Dec 29, 1998Kanegafuchi Kagaku Kogyo Kabushiki KaishaAdjuvant for pharmaceutical preparations
US5971942 *Dec 3, 1996Oct 26, 1999Gu; Howard H.Intestinal fluid sampler
US8491495 *Nov 30, 2012Jul 23, 2013L. Zane ShuckHuman intestinal tract research and diagnostic system to evaluate patients and advance medical science and bioengineering and to determine processes in the gut and causes of diseases
US20140163416 *Jun 28, 2013Jun 12, 2014L. Zane ShuckIn Vivo Device and Method for Researching GI Tract Processes, Microbes, and Variables Associated with Illnesses and Diseases
EP0542299A2 *Nov 13, 1992May 19, 1993Kanegafuchi Kagaku Kogyo Kabushiki KaishaEster linkage containing polymers for use in pharmaceutical preparations
WO1989000403A1 *Jul 8, 1988Jan 26, 1989Huhtamaeki OyDevice and method for the determination of incisional wound healing ability
WO2001017509A1 *Sep 5, 2000Mar 15, 2001Beisel GuentherMethod for improving and maintaining bowel function as well as a method for the production thereof
WO2001017510A1 *Sep 5, 2000Mar 15, 2001Guenther BeiselAgent for stimulating bowel function and method for producing the same
WO2002015887A1 *Jul 20, 2001Feb 28, 2002Brown Edwin ChristopherConsumable container
Classifications
U.S. Classification600/572, 600/582
International ClassificationA61B10/00, A61B10/02, A61K9/48
Cooperative ClassificationA61B10/02, A61K9/4891, A61K9/4866
European ClassificationA61K9/48H6, A61B10/02, A61K9/48Z