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Publication numberUS3694547 A
Publication typeGrant
Publication dateSep 26, 1972
Filing dateNov 5, 1971
Priority dateNov 10, 1970
Also published asCA958646A1, DE2153386A1, DE2153386B2, DE2153386C3
Publication numberUS 3694547 A, US 3694547A, US-A-3694547, US3694547 A, US3694547A
InventorsErnst Ludwig Forsthoff
Original AssigneeLever Brothers Ltd
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Anti-dandruff hair preparation
US 3694547 A
Abstract
This invention relates to hair preparations having activity against dandruff, containing as an anti-dandruff agent the proteolytic enzyme material rennet. One form of the hair preparations is a lotion, for example an aqueous or alcoholic solution or emulsion of rennet having a pH of from 2 to 9. Rennet may also be incorporated in shampoos, creams, sprays and gels.
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Description  (OCR text may contain errors)

United States Patent Forsthofi 1 Sept. 26, 1972 [54] ANTl-DANDRUFF HAIR PREPARATION [56] References Cited [72] Inventor: Ernst L ldwig Forsthoff, Schenefeld, OTHER PUBLICATIONS Kreis Pmneberg, Germany Cayle, Journal of the Society of Cosmetic Chemists, Vol. 14, No. 6, page 254, June 1963 [73] Assignee: Lever Brothers Company, New

York, Primary ExaminerRichard L. Huff N 5, Attorney-Louis Kline, J1. fit al.

[21] Appl. No.: 196,226 [57] ABSTRACT This invention relates to hair preparations having ac- [30] Foreign Application Priority Data tivity against dandruff, containing as an anti-dandruff agent the proteolytic enzyme material rennet. One 1970 Luxembourg "62030 form of the hair preparations is a lotion, for example an aqueous or alcoholic solution or emulsion of rennet [52] U.S. Cl. ..424/94, 424/DlG. 4 having a pH of from 2 to Rennet may also be incop Int. Cl. porated in shampoos, creams p y and g Field of Search ..424/DIG. ,4, 94, 7O

7 Claims, No Drawings ANTl-DANDRUFF HAIR PREPARATION This invention relates to hair preparations containing rennet and particularly to lotions containing rennet for the control of dandruff.

beneficial effect on the skin. It has also been suggested trypsin should be added to dental preparations in order to dissolve protein-containing food residues. Proteolytic enzymes, such as keratinase have also been suggested for use as depilatories.

Tryptic enzymes, such as pancreatin, have not proved very suitable for hair preparations, (which are generally acidic), since they are most effective at about pH 8.5. A similar objection is open to the use of lipases (mixtures of proteolytic enzymes) which have also been suggested.

We have now discovered that desirable effects can be imparted to hair preparations by the incorporation therein of rennet, and that these effects can be obtained from both acidicand weakly alkaline preparations.

Accordingly the present invention provides a hair preparation having activity against dandruff comprising, as an antidandruff agent from about 0.02 to about 1 percent by weight of rennet.

More particularly we have discovered that hair lotions containing rennet are effective in controlling dandruff.

Rennet isa substance normally used in cheese-making (and which is therefore commercially available) which contains the enzyme chymosin. It is usually prepared microbiologically; or alternatively it can be isolated from natural sources such as calves stomachs.

in" general the'amount of rennet required to give an acceptable antidandruff effect in the composition of the invention is from 0.0l to 1 percent, preferably 0.01 to 0.5 percent by weight.

The most suitable form of hair preparation according to the invention is a lotion, that is an aqueous, alcoholic or aqueous/alcoholic solution or emulsion containing rennet, although'other forms, for example shampoos, gels and creams are not excluded. Preferably the pH of the preparation will be from 2 to 9, most preferably from 4.5 to 7. A particularly preferred mode of obtaining a composition within the pH range is to formulate it to include a buffer so that it is buffered at from about pH 5-6. r

The invention will be further described in the following examples in which the rennet used was of the activity stated in brackets:

EXAMPLE 1 This is an example of an alcoholic hair lotion by weight Rennet l :220,000) 0.05

lsopropanol 50.00

Perfume 0.30

Water balance EXAMPLEZ This is an example of an aqueous hair lotion I: by weight Rennet l:220,000) 0.05 Sodium benzoate 0. l 5 Perfume 0.2 Water balance EXAMPLE 3 This is an example of an aqueous/alcoholic hair setting preparation by weight Luviskol VA64 2.0 Rennet l:l00,000) 0.1 lsopropanol 45.0 Perfume 0.4 Water balance Luviskol VA64 (Trade Mark) is a commercially available polyvinylpyrrolidone/vinyl acetate copolymer.

EXAMPLE 4 This is an example of a hair preparation in the form of a gel Carbopol 940 (Trade Mark) is a carboxyvinyl polymer which functions as a thickening agent.

EXAMPLE 5 This is an example of a hair cream preparation by weight Paraffin Oil 1 Lanolin Glycerine Cityl alcohol Lanette N Rennet (l:l00,00) p-l-lydroxybenzoic acid-ethyl ester Perfume Water balance Lanette N (Trade Mark) is a 9:1 mixture of cetyl stearyl alcohol/sodium cetyl stearyl sulphate.

EXAMPLE 6 This is an example of a hair preparation in the form of a conditioner by weight Katioran (Trade Mark) is a hydrophilic fatty acid condensation product.

EXAMPLE 7 This is an example of a hair preparation in the form of a shampoo by weight Sodium alkyl polyglycol ether sulphate l5.2 Ethylene glycol distearate l.0 Sodium chloride 2.0 Technical grade rennet powder 0.5 Perfume 0.5 Water balance The composition was adjusted to pH 5.5 with citric acid.

EXAMPLE 8 This is an example of a hair preparation in the form of a cream lotion k by weight Stearyl alcohol 3.5 Stearyl alcohol polyglycol ether 3.5 Spermaceti 5.0 lsopropyl myristate 3.0 Glycerine 5.0 Technical grade rennet powder 0.1 Perfume 0.4 Water balance This composition was emulsified and found to have a pH of 6.4.

EXAMPLE 9 The following experiment was performed to ascertain the effectiveness of a lotion of the formulation shown in Example 1 in combatting dandruff.

A group of 100 people with bad or moderate dandruff were asked to apply the lotion twice a day and to wash their hair at the beginning of the trial period but not during it. A second group of 100 were asked to apply a lotion of the following formula in the same way:

i: by weight Salicyclic acid 2 isopropanol 48 Water 50 A third group of were asked to apply a 50 percent aqueous solution of isopropanol as a blank. The results of these tests are given in Table i.

TABLE 1 Number of persons showing a marked reduction of dandruff after use of lotion No. of days Lotion with elapsed Lotion of Ex. I salicyclic acid Blank lotion 3 I8 29 i2 6 26 38 l8 10 3| 54 22 I4 52 63 28 After 14 days the treatment was discontinued and the number of persons whose hair condition relapsed was noted. The results of this part of the experiment are shown in Table 2.

tive than one containing salicylic acid and salicylic acid lotions have been suggested as antidandruff agents in the past.

What is claimed is:

l. A hair preparation having activity against dandruff comprising, as an anti-dandruff agent from about 0.0] to about 1 percent by weight of rennet.

2. A hair preparation according to claim 1 wherein the rennet is in aqueous or alcoholic emulsion or solution.

3. A hair preparation according to claim 1 in the form of a lotion.

4. A hair preparation according to claim 1 in the form of a shampoo.

5. A hair preparation according to claim 1 having a pH of from about 2 to about 9.

6. A hair preparation according to claim 5 having a pH of from about 4.5 to about 7.

7. A hair preparation according to claim 6 having a pH buffered at from about 5 to about 6.

Non-Patent Citations
Reference
1 *Cayle, Journal of the Society of Cosmetic Chemists, Vol. 14, No. 6, page 254, June 1963
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US3949087 *Aug 5, 1974Apr 6, 1976LabazCarnitine chloride
US5834409 *Feb 8, 1996Nov 10, 1998Colgate-Palmolive CompanyScalp care products containing anti itching/anti irritant agents
US6375948 *Jul 11, 2000Apr 23, 2002Kao CorporationTreating method for suppressing hair growth
US7056499Feb 8, 2002Jun 6, 2006Kao CorporationFor suppressing the growth of the body hair, thereby decreasing the removing frequency of the body hair
US7211278Feb 13, 2004May 1, 2007Kao CorporationTreating method for suppressing hair growth
US7744925May 20, 2005Jun 29, 2010Quadrant Drug Delivery LimitedInsulin and a sugar alcohol; powder for pulmonary delivery; inhalants; storage stability
US7780991May 20, 2005Aug 24, 2010Quadrant Drug Delivery Limitedfor ballistic administration of a bioactive material to subcutaneous and intradermal tissue, delivery vehicle being sized and shaped for penetrating the epidermis; vehicle further comprises a stabilizing polyol glass, in particular, trehalose
US7785631May 20, 2005Aug 31, 2010Quadrant Drug Delivery LimitedSolid dose delivery vehicle and methods of making same
US7807707 *Feb 27, 2006Oct 5, 2010Conopco Inc.inflammatory skin conditions such as scalp skin itching and flaking associated with dandruff; shampoo; naphthalen-1-ylamino)-acetic acid (2-oxo-1-phenethyl-1,2-dihydro-indol-3-ylidene)-hydrazide
US20110243876 *Apr 1, 2011Oct 6, 2011Rajan Keshav PanandikerOrganosilicones
USRE37872 *Mar 17, 1999Oct 8, 2002Inhale Therapeutics Systems, Inc.Enzymes
USRE38385 *Aug 28, 2001Jan 13, 2004Nektar TherapeuticsProteins, peptides, nucleosides, nucleotides; carrier carbohydrates and and sugars which are water soluble or water swellable and in a glassy amorphous state; storage stability
USRE39497 *Aug 28, 2001Feb 27, 2007Nektar TherapeuticsStorage of materials
Classifications
U.S. Classification424/94.66, 424/DIG.400
International ClassificationA61Q5/00, A61K8/66, A61Q5/02
Cooperative ClassificationA61K8/66, A61Q5/00, Y10S424/04, A61Q5/02, A61Q5/006
European ClassificationA61Q5/00F, A61K8/66
Legal Events
DateCodeEventDescription
May 12, 1988ASAssignment
Owner name: CPPD, INC., C/O CT CORPORATION SYSTEM 208 LASALLE
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:LEVER BROTHERS COMPANY, A CORP. OF ME;REEL/FRAME:004888/0628
Effective date: 19880101
Owner name: CPPD, INC., A CORP. OF IL, ILLINOIS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:LEVER BROTHERS COMPANY, A CORP. OF ME;REEL/FRAME:004888/0628