Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS3704096 A
Publication typeGrant
Publication dateNov 28, 1972
Filing dateOct 16, 1970
Priority dateOct 16, 1970
Publication numberUS 3704096 A, US 3704096A, US-A-3704096, US3704096 A, US3704096A
InventorsEskil L Karlson, Christ J Verses
Original AssigneePollution Control Ind Inc
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Sterilizing package and method and means for sterilizing an article and thereafter checking its sterility
US 3704096 A
Images(1)
Previous page
Next page
Description  (OCR text may contain errors)

Nov. 28, 1912 c J. VERSES Em 3,704,096

STERILIZING PACKAGE AND METHOD AND MEANS FOR STERILIZING AN ARTICLE AND THEBEAFTER CHECKING ITS STERILITY Filed Oct. 16. 1970 INVENTORS F513 IL {far-[$021 ('lzns't Vrses United States Patent M STERILIZING PACKAGE AND METHOD AND MEANS FOR STERILIZING AN ARTICLE AND THEREAFTER CHECKING ITS STERILITY Christ J. Verses, Fairfield, and Eskil L. Karlson, Stamford, Conn., assignor to Pollution Control Industries, Inc., Stamford, Conn.

Filed Oct. 16, 1970, Ser. No. 81,256 Int. Cl. G01d 21/00; G01n 31/22 US. Cl. 23-230 R 4 Claims ABSTRACT OF THE DISCLOSURE Means are provided to indicate by color change or lack of color change occurring within a predetermined time interval whether a sterilizing environment has been attained in a sealed container filled with ozone mist. A new package is provided comprising a transparent, sealed container having therein an ozone mist sterilizing environment, an article to be made and kept sterile by said environment, and an indicator adapted to visually signal whether such environment has in fact been attained.

FIELD OF USE This invention relates to sterilizing an article and maintaining it in sterile condition ready for use at any future time, by placing it in an ozone mist environment, and to means for indicating whether a sterilizing environment has actually been attained; and to a sealed package containing ozone mist, the article and the indicator means. While applicable to a wide range of articles, use is particularly contemplated in connection with surgical instruments, surgical gloves and other items of hospital equip- SUMMARY OF THE DISCLOSURE An article to be made sterile is placed in a transparent container such as a plastic bag which, after being evacuated, is refilled with a mixture of ozone gas and water particles under pressure. When this mixture encounters the low pressure within the newly evaucated container the water particles explode forming an intimate mixture of ozone gas and finely divided water particles, referred to herein as ozone mist. The amount of ozone in the mixture of ozone gas and water particles forced into the bag under pressure is suflicient to provide in the container an ozone concentration of one thousand (1,000) parts per million (1,000,000) by weight. The amount of water in the mixture which is forced into the bag is sufiicient to establish a condition of saturation, or at least 80% humidity, within the bag after it is sealed. The container is then vibrated or tumbled to expose the entire surface of the article to the ozone mist. As a check, in order to be 3,704,096 Patented Nov. 28, 1972 sure that in the sealed bag there is sufiicient ozone concentration and suflicient humidity to kill all germs and viruses which may be on the article or on the inner surface of the bag, means are provided and included in the bag which are adapted to indicate by a color change occurring within a predetermined period of time after sealing of the bag that a sterile condition has been attained within the bag, or to warn by lack of color change that a sterile condition has not been attained.

The invention will be best understood by reading the following description in connection with the drawing, in which the figure is an elevation of a sealed flexible plastic bag having therein an article to be sterilized in an environment of ozone mist, and containing also color speci mens adapted to indicate by complete color change or lack of such change whether a dependable sterilizing condition has been attained within the sealed bag.

DESCRIPTION In practicing the invention in accordance with the embodiment thereof disclosed herein an article 10 to be sterilized is placed in a container, preferably in a transparent container such as a plastic bag 12 and along with two color specimens 22 and 26 the function of which is described below, the bag is first evacuated and then filled with ozone mist, the presence of which is indicated by numeral 18, and sealed. A mixture of ozone gas and water is preferably supplied into this bag under pressure and expands to form a fine mist. The article in the container is made to move and expose all of its surfaces to the ozone mist. The exhausting of the bag 12, refilling it with ozone mist and vibrating the article within the bag may desirably be done by the method and apparatus disclosed in copending US. patent application Ser. No. 81,255 filed Oct. 16, 1970.

The concentration of ozone necessary to kill all germs and viruses on an article enclosed in the bag 12 may vary with the locality and altitude but tests indicate that a concentration on the order of one thousand (1,000) parts by weight of ozone per million (1,000,000), in an environment sufficiently humid to promote the effectiveness of the ozone and to bring the ozone into contact with the entire surface of the article, will produce a reliable overkill situation. The humidity should be or more at room temperature.

If the amounts of ozone and water supplied into the bag 12 are controlled to give the ozone concentration and humidity percentage referred to above, optimum results will be attained, but as a check to determine, after the bag 12 is sealed, whether the article therein has been made completely sterile, the color change indicator means referred to above are employed.

In the drawing a pair of surgical shears is shown as the article 10 to be rendered sterile and maintained in sterile condition. A strip of adhesive tape 20 having on it a spot 22 of Safranin O dye is shown applied on one handle of the shears and a strip of adhesive tape 24 having on it a spot 26 of cobaltous chloride is shown applied on theother handle of the shears. The spots 22 and 26 can be seen through the wall of bag 12 and any change in color of these spots can be observed.

Safranin O is a dye, also known as aniline rose or aniline pink, prepared by oxidizing para-toluylenediamine aniline and ortho-toluidine. It is made by National Aniline Division of Allied Chemical Corporation. When exposed to ozone, Safranin O bleaches and loses its characteristic TABLE Concentration of Safranin (by weight): 25

Time for complete bleach (minutes) Dehydrated cobaltous chloride, CoCl 6H O, which is blue, turns red almost immediately when placed in an environment where the humidity is 80% or more. Since this humidity indicator reacts much faster than the said ozone concentration indicator both color indicators may be observed at the end of the time interval required to eifect a complete color change of the Safranin indicator.

By observing both indicators 22 and 26 promptly after the periods of time indicated in the table, one can visually determine whether in fact a condition has been obtained in the bag to render the article 10 therein completely sterile.

What we claim is:

1. The method of indicating whether ozone mist, comprising mixture of ozone gas and finely divided water particles, sealed in a transparent container along with an article to be sterilized has high enough ozone concentration and humidity to sterilize the said article, which comprises, enclosing in the container, along with the article and ozone mist, a specimen of Safranin O and a specimen of dehydrated cobaltous chloride and observing the said specimens for color change after a time interval within which said Sa-franin O and said dehydrated cobaltons chloride are known to change color in a concentration of ozone and under conditions of humidity known to kill germs and viruses.

2. A package comprising a sealed transparent container having therein, ozone mist, an article to be rendered sterile by the ozone mist, and specimens of Safranin O and dehydrated cobaltous chloride to indicate by change of color, occurring within a predetermined time interval following sealing of the container, whether the desired sterile condition within the container has been attained.

3. The package claimed in claim 2 in which the indicator responsive to a germ-killing concentration of ozone is Safranin O and in which the indicator responsive to the humidity of the environment is dehydrated cobaltous chloride.

4. The package claimed in claim 2 in which the specimens of Safranin O and dehydrated cobaltous chloride comprises thin strips of adhesive tape applied to the article and stained respectively with Safranin O' and dehydrated eohaltous chloride.

References Cited UNITED STATES PATENTS 1/1949 Davis 23253 TP 11/1969 Andersen et al 2191 OTHER REFERENCES Kolling et a1., Chem. Abstr. 55, 2559lh (1961).

MORRIS O. WOLK, Primary Examiner R. M. R-EESE, Assistant Examiner

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3852034 *Jun 21, 1972Dec 3, 1974American Sterilizer CoIndicator for effectiveness of ethylene oxide sterilization
US3862824 *May 30, 1974Jan 28, 1975Arthur William ChapmanMeans for indicating completion of sterilisation processes
US3890955 *Jan 15, 1974Jun 24, 1975Elliott AngelikaVacuum indicator
US4079729 *Oct 31, 1975Mar 21, 1978Sherwood Medical Industries Inc.Fluid collection with vacuum loss indicating means
US4179397 *May 22, 1978Dec 18, 1979American Can CompanyThermotropic; resole resin, alcohol solvent, combination of dyes; low temperature sterilization
US4188437 *May 25, 1978Feb 12, 1980American Can CompanyThermotropic adhesive tape
US4511035 *Jan 13, 1983Apr 16, 1985Ethicon, Inc.Package for surgical instrument
US4514361 *Sep 24, 1982Apr 30, 1985Arvey CorporationSteam sterilization indicator
US5069880 *Jan 22, 1991Dec 3, 1991Karlson Eskil LWater purification
US5115166 *Aug 31, 1990May 19, 1992Abtox, Inc.Plasma sterilizer and method
US5139957 *May 24, 1990Aug 18, 1992American Sterilizer CompanyChemical indicator that includes potassium dichromate and urea and method of using the same to detect hydrogen peroxide
US5178829 *Aug 31, 1990Jan 12, 1993Abtox, Inc.Exposure until temperature reaches preselected maximum, terminating and repeating
US5184046 *Sep 28, 1990Feb 2, 1993Abtox, Inc.Circular waveguide plasma microwave sterilizer apparatus
US5186893 *Aug 31, 1990Feb 16, 1993Abtox, Inc.Plasma cycling sterilizing process
US5244629 *Aug 27, 1991Sep 14, 1993Caputo Ross APlasma sterilizing process with pulsed antimicrobial agent pretreatment
US5288460 *Oct 19, 1992Feb 22, 1994Abtox, Inc.High speed, nontoxic, environmentally safe; for medical equipment
US5325020 *Oct 15, 1992Jun 28, 1994Abtox, Inc.Circular waveguide plasma microwave sterilizer apparatus
US5344017 *Aug 13, 1993Sep 6, 1994Wittrock Paul MInstrument pouch with in-pouch sterile processing indicator
US5376332 *Feb 22, 1993Dec 27, 1994Abtox, Inc.Plasma sterilizing with downstream oxygen addition
US5413758 *May 21, 1993May 9, 1995Abtox, Inc.Vacuum pumps, bactericides and plasma generators
US5413759 *Jun 7, 1993May 9, 1995Abtox, Inc.Medical instruments, preventing nascent plasma from directly impinging objects to be sterilized
US5413760 *May 18, 1992May 9, 1995Abtox, Inc.Plasma sterilizer and method
US5472664 *Mar 21, 1994Dec 5, 1995Abtox, Inc.Noble gas with hydrogen and oxygen
US5518763 *Jun 5, 1995May 21, 1996Minnesota Mining And Manufacturing CompanyMethod of making indicator tapes
US5593649 *Jun 5, 1995Jan 14, 1997Abtox, Inc.Canister with plasma gas mixture for sterilizer
US5618492 *Jan 5, 1996Apr 8, 1997Auten; Richard D.Placing article in container of solution with dissolved ozone, sealing container, applying ultraviolet radiation after specified time to sterilize article and degrade ozone
US5645796 *Jun 5, 1995Jul 8, 1997Abtox, Inc.Process for plasma sterilizing with pulsed antimicrobial agent treatment
US5650693 *Jun 5, 1995Jul 22, 1997Abtox, Inc.Plasma sterilizer apparatus using a non-flammable mixture of hydrogen and oxygen
US5692610 *Apr 29, 1996Dec 2, 1997Porteous; Don D.Method and apparatus for single use dispenser packaging of dental retraction cords
US5868999 *Mar 19, 1996Feb 9, 1999Ozone Sterilization Products, Inc.Humidified ozone sterilant from oxygen gas; continuous partial recirculation of ozonated gas formed in the generator, cooling system; catalytic destruction of excess ozone; quick kill time
US5942438 *Nov 7, 1997Aug 24, 1999Johnson & Johnson Medical, Inc.Exposing surface having metallic azo dye to sterilization, viewing dye for change of color; adequate sterilization or limited reuse indicators
US6063631 *May 21, 1997May 16, 20003M Innovative Properties CompanyMonitoring a sterilization process using hydrogen peroxide vapor by exposing item and indicator containing acid fuchsin to vapor which causes indicator to become colorless; for medical equipment
US6117685 *May 22, 1998Sep 12, 2000Sakura Color Products CorporationOzone indicator and ozone detecting ink
US6218189Apr 13, 1999Apr 17, 2001Johnson & Johnson Medical, Inc.Detecting antiseptic incubation; incubation of surface with bleachable dye, monitoring color change
US6238623Feb 5, 1998May 29, 20013M Innovative Properties CompanyLabels and tracking systems for sterilization procedures
US6261518Oct 30, 1998Jul 17, 2001Depuy Orthopaedics, Inc.Sterilization for interiors with plasma gas and microbiocides
US6287518Feb 5, 1998Sep 11, 20013M Innovative Properties CompanySterilization monitors
US6302691Sep 22, 2000Oct 16, 2001Nicholas J. ManzoliUse indicating means for dental files
US6336964Jul 10, 2000Jan 8, 2002Sakura Color Products CorporationOzone indicator and ozone sensor ink
US6346417Jan 5, 2000Feb 12, 20023M Innovative Properties CompanySterilization monitors
US6440744Jan 5, 2000Aug 27, 20023M Innovative Properties CompanySterilization monitoring method
US6551555Dec 19, 2000Apr 22, 2003Ethicon, Inc.Apparatus with a chemical indicator for indicating exposure to an oxidative sterilant or disinfectant
US6589479Jun 13, 2001Jul 8, 2003Technologies Of Sterilization With Ozone Tso3, Inc.Method of monitoring sterilization and indicator therefor
US6706537Aug 2, 2001Mar 16, 20043M Innovative Properties CompanyOf peracid sterilization vapor, using as indicator a colorant susceptible to halogenation and a halogen source to a peracid vapor, said colorant changes color when halogenated; e.g. phenol red and potassium bromide indicator; peracetic acid
US6734157Dec 22, 2000May 11, 2004Kimberly-Clark Worldwide, Inc.Multilayer laminate
US6767509Jun 12, 2000Jul 27, 2004Kimberly-Clark Worldwide, Inc.Self-sterilizing packaging
US6794318Dec 22, 2000Sep 21, 2004Kimberly-Clark Worldwide, Inc.Use-dependent indicator system for absorbent articles
US6916480Dec 22, 2000Jul 12, 2005Kimberly-Clark Worldwide, Inc.Wiper containing a controlled-release anti-microbial agent
US6969197 *Apr 5, 2002Nov 29, 2005Ronpak, Inc.Sterilizable package
US7560082Oct 13, 2004Jul 14, 2009Allegiance CorporationSterilization wraps and methods for sterilizing articles
US7906070Jun 11, 2009Mar 15, 2011Allegiance CorporationSterilization wraps and methods for sterilizing articles
US20110076191 *Sep 25, 2009Mar 31, 2011Germgard Lighting, Llc.Ozone Based Method and System for Tool Sterilization
EP1163913A2 *Jun 15, 2001Dec 19, 2001Technologies of Sterilization with Ozone TSO3 Inc.Method of monitoring sterilization and indicator therefor
EP2299263A1 *Sep 2, 2010Mar 23, 2011Krones AGMethod for testing a sterilisation process and sterilisation device
WO1990007466A1 *Dec 27, 1988Jul 12, 1990Eskil L KarlsonOzone generation by corona discharge at elevated pressures
Classifications
U.S. Classification436/1, 422/29, 116/207, 116/201, 206/459.1, 422/186, 422/28, 436/41, 206/210, 422/3, 206/363, 436/135, 422/87
International ClassificationA61L2/28, A61L2/26, G09F3/00, A61B19/00
Cooperative ClassificationA61B2019/5437, A61B2019/4868, G09F3/00, A61L2/28, A61L2/26
European ClassificationA61L2/26, G09F3/00, A61L2/28