Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS3717174 A
Publication typeGrant
Publication dateFeb 20, 1973
Filing dateAug 3, 1971
Priority dateAug 3, 1971
Also published asCA999499A, CA999499A1, DE2237858A1
Publication numberUS 3717174 A, US 3717174A, US-A-3717174, US3717174 A, US3717174A
InventorsR Dewall
Original AssigneeR Dewall
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Perfusion safety valve
US 3717174 A
Abstract
A perfusion safety valve for use in blood oxygenating systems. The valve includes an elongated, rigid, perforated tube and interiorly disposed therein is a collapsible membrane-like wall which may collapse to cut off the flow of blood through the tube. Exteriorly of the tube is a second membrane-like wall and the space between the two membrane walls is filled with a liquid. When a slight vacuum is pulled against the inner membrane wall, the liquid will pass through the perforations of the tube into the interior of the tube to cause collapse of the interior wall to shut off the flow through the valve to preclude the pumping of air into the arterial system of a patient using the oxygenating system.
Images(1)
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

Emit/ed States Patent 1 Dewall [54] PERFUSION SAFETY VALVE [76] Inventor: Richard A. Dewall, 247 Northview Rd., Dayton, Ohio 45419 [22] Filed: Aug. 3, 1971 [211 Appl. No.: 168,642

[52] U.S. Cl ..137/565, 23/2585, 128/214 R, 137/525, 251/5 [51] Int. Cl. ..A61m 5/16 [58] Field of Search...23/258.5; 251/4, 5; 128/214 R, 128/214 E, 214 F, 274; 137/494, 511, 525, 525.1, 565; 3/DIG. 3

[56] References Cited UNITED STATES PATENTS 3,513,845 5/1970 Chesnut et al. ..l28/2l4 R 2,756,959 7/1956 Hill ..251/5 2,572,658 10/1951 Perkins v ..l37/494 X 3,183,908 5/1965 Collins et al.. ..23/258 5 3,204,631 9/1965 Fields 23/258 5 2,964,285 12/1960 Bardet ..25l/5 1 Feb. 20, 1973 2,982,511 5/1961 Connor ..251/5 Primary ExaminerAlan Cohan Assistant Examiner-Gerald A. Michalsky Attorney-Axel A. Hofgren et al.

[57] ABSTRACT A perfusion safety valve for use in blood oxygenating systems. The valve includes an elongated, rigid, perforated tube and interiorly disposed therein is a collapsible membrane-like wall which may collapse to cut off the flow of blood through the tube. Exteriorly of the tube is a second membrane-like wall and the space between the two membrane walls is filled with a liquid. When a slight vacuum is pulled against the inner membrane wall, the liquid will pass through the perforations of the tube into the interior of the tube to cause collapse of the interior wall to shut off the flow through the valve to preclude the pumping of air into the arterial system of a patient using the oxygenating system.

3 Claims, 5 Drawing Figures e 0 XYGEN/l To PA TIE/VT vm v5 K14 PERFUSION SAFETY VALVE BACKGROUND OF THE INVENTION This invention relates to perfusion safety valves par ticularly suited for use in blood oxygenating systems.

The continuing progress of medical science has resulted in highly complicated surgical procedures becoming relatively commonplace. One class of such procedures involves the use of heart lung machines or the like wherein blood is removed from the venous system of a patient, oxygenated and returned to the arterial system of the patient. Typically, structures known as oxygenators are employed in such procedures and require monitoring by trained personnel to insure that blood in the oxygenating system will not be exhausted with the result that air might be pumped into the patient to cause air embolism, a condition frequently resulting in death. As a safeguardagainst inattentive.- ness of an attendant monitoring the blood level in the oxygenating system, it is desirable to provide means for automatically cutting off the flow of blood should blood reach a predetermined degree of exhaustion to preclude the pumping of air into the patient, such as a valve.

SUMMARY OF THE INVENTION It is a principal object of the invention to provide a new and improved perfusion safety valve for receipt in a blood oxygenating system that is responsive to exhaustion of blood in an oxygenator or the like to automatically stop the flow of fluid through a line leading to the patient to preclude the pumping of air into the patients arterial system and the attendant catastrophic results. More particularly, it is an object of the invention to provide such a valve that is inexpensive to manufacture, is positive in its action without requiring the use of equipment peripheral-to that employed in the oxygenating system to perform its function, and which may be disposed of after a single use if desired.

The exemplary embodiment of the invention achieves the foregoing objects by means of a construction employing an elongated, perforated, rigid tube. About the entire inner periphery of the tube there is provided a flexible, blood compatible membrane, while exteriorly of the tube, a generally similar membrane is provided. The two membranes are arranged with respect to each other and to the tube such that the closed space between the two membranes having a volume at least slightly greater than the volume of the interior of the tube results. The close space is filled with a biologically harmless liquid such as a saline solution.

When employed in an oxygenating system, the typical positive displacement pump for the blood line is located downstream of the valve, and the valve is located downstream of an oxygenator or the like. Normally, the head of the blood in the oxygenator will be sufficient to maintain the inner membrane in substantial abutment with the interior wall of the tube so that blood may flow therethrough. When the head decreases to a certain value, the slight vacuum pulled by the pump will result in atmospheric pressure being applied to the outer membrane forcing the liquid in the closed space through the perforations into the tube to the interface between the interior of the tube and the inner membrane thereby causing the latter to collapse upon itself to terminate the flow of fluid through the line.

Thus, the construction requires no operating components other than the positive displacement pump used in the oxygenating system itself and should the same fail, it will be obvious that there would be no chance of air embolism by reason of the ceasing of the pumping action. This is in contrast to an arrangement wherein exterior equipment: might be employed to control the valve position which equipment could fail while the pump continued in operation, in which case, the valve would be ineffective.

For ease of use, barbed tubular extensions are secured to opposite ends of the tube for connection into typical plastic blood conduit tubing employed in such systems.

Other objects and advantages will become apparent from the following specification taken in conjunction with the accompanying drawings.

DESCRIPTION OF THE DRAWINGS FIG. 1 is a flow diagram illustrating a typical oxygenating system with which the inventive valve is designed to be employed;

FIG. 2 is a sectional view of a valve made according to the invention showing the component parts when the valve is open;

FIG. 3 is a sectional view of the valve in a closed condition;

FIG. 4 is a cross section of the valve in an open condition; and

FIG. 5 is a cross section of the valve in a closed condition.

DESCRIPTION OF THE PREFERRED EMBODIMENT One typical system in which a valve made according to the invention is intended to be used is illustrated in schematic form in FIG. 1 and is seen to include a conventional blood oxygenator 10 adapted to receive venous blood from a patient 12. Downstream of the oxygenator 10, and physically below the oxygenator is a perfusion safety valve, generally designated 14, so that a head of blood is applied thereto. Downstream of the valve 14 is a positive displacement pump 16 which, in turn, provides oxygenated blood to the arterial system of the patient. As will be seen, the physical location of the valve 14 with respect to the oxygenator 10 is of some significance insofar as the valve in part responds to the lack of establishment of a predetermined head of blood applied thereto. This factor, coupled with the slight vacuum pulled by the positive displacement pump 16, will cause the valve 14 to close if the blood in the oxygenator reservoir 10 becomes exhausted.

Turning now to FIG. 2, an exemplary embodiment of the valve 14 is illustrated in cross section. The valve 14 comprises an elongated, rigid tube 18 which may be formed of polycarbonate, methacrylate or similar plastic. The tube 18 is perforated as at 20 (additional perforations 20 may be located along virtually the entire length of the tube 18, if desired) and includes internal steps 22 at its ends.

Within the tube 18 is a circumferential membrane film 24 defining a blood impermeable wall. The membrane 24 is sufficiently flexible so that the same may collapse upon itself within the interior of the tube to cut off the flow of fluid therethrough and is formed of any suitable blood compatible material such as silicone rubber or a polyvinyl plastic.

Exteriorly of the tube 18 is a second peripheral membrane film 26, also formed of any suitable flexible material. The membranes 24 and 26 define a closed space 28 having a volume at least slightly greater than the volume of the interior of the tube 18 between the ends of the membranes 24 and 26 (and in the embodiment illustrated in FIGS. 2 and 3, the ends of the tube 18) and which is adapted to receive biologically harmless liquid such as a saline solution. If desired, the outer film 26 may be provided with a suitable sealable port (not shown) for the purpose of introducing a liquid into the closed space 28.

The ends of the membrane 26 are sealingly secured to the ends of the tube 18 in any suitable fashion to partially define the closed space 28 while the ends of the membrane 24 may be received in the steps 22 of the tube 18. To maintain the same in sealed engagement therewith, any suitable means such as an adhesive may be employed or, in the alternative, for the two-fold purpose of establishing sealing engagement between the membrane 24 and the tube 18 and to facilitate connec tion of the latter into blood conduit tubing, tubular extensions 30 having complementary steps 32 may be received in the steps 22 and secured thereto to sealingly hold the ends of the membrane 24 thereagainst. The extensions 30 include barbed ends 34 for receipt into conventional plastic tubing employed in the blood line.

In operation, a suitable conduit from the oxygenator will be secured to one of the barbed extensions 30 while the conduit to the pump 16 will be secured to the other barbed extension 30. As long as the head of blood within the oxygenator reservoir exceeds a predetermined level, the pressure of the same will maintain the membrane 24 in the position illustrated in FIGS. 2 and 4 so that blood may pass through the valve 14 to the pump 16 and then to the patient 12. However, should the head of blood in the reservoir fall below the desired level, the slight vacuum pulled by the pump will result in the atmospheric pressure applied to the outer membrane 26 collapsing the same driving the saline solution within the closed space 28 through the perforations to force the inner membrane 24 to seal upon itself as illustrated in FIGS. 3 and 5 to halt the flow of fluid through the line while at least a minimal quantity of blood remains therein to preclude any possibility of air embolism.

According to one embodiment of the invention, the internal diameter of the tube 18 is about three-eighths of an inch while the length of the surface of the inner membrane 24 that may collapse upon itself will be at least ten times that length so that the capability of sealing upon collapse is enhanced. For a typical construction, this would require a length on the order of 4 to 6 inches.

From the foregoing, it will be appreciated that a valve made according to the invention does not require operating equipment other than that found in the oxygenating system itself so that system failure cannot be occasioned by failure of peripheral equipment. Moreover, the simplicity of construction coupled with positive action results in an inexpensive construction that is completely reliable and one which may be disposed of after a single use.

I claim: 1. A blood oxygenating system including a perfusion safety valve comprising an elongated, relatively rigid, perforated tube; means at each end of said tube for connecting the same into a conduit in which blood is flowing; a peripheral inner membrane wall formed of a flexible material compatible with blood within said tube; an outer membrane wall outside of said tube; said inner and outer membrane walls defining a closed space; and a liquid within said closed space; whereby when blood is flowing through said tube, said inner membrane wall will be in substantial abutment with the internal surface of said tube while when blood ceases to flow to said tube, a slight vacuum in the blood line will cause the liquid in said closed space to flow through the perforations in said tube to cause said inner membrane wall to collapse upon itself to seal off the blood line, a blood oxygenator adapted to receive blood from a patient for oxygenating the same; means establishing a blood flow path from said oxygenator to one of said connecting means; a blood pump; means establishing a blood flow path from the other of said connecting means to said blood pump, said blood pump being adapted to conduct oxygenated blood to the patient and further being a positive displacement pump whereby a slight vacuum may be pulled upstream of the same so that the absence of blood flowing from said oxygenator to said valve will result in said valve closing to preclude the pumping of air into the arterial system of the patient.

2. The blood oxygenating system of claim 1 wherein said inner membrane wall has a length equal to about at least ten times the cross sectional dimension of "said tube; said closed space has a volume at least slightly greater than the volume of the interior of said tube along the length of the inner membrane wall; and the liquid in said closed space is a biologically harmless liquid.

3. A blood oxygenating system according to claim 2 wherein said connecting means comprise barbed, tubular extensions on both ends of said tube.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2572658 *Feb 16, 1948Oct 23, 1951Perkins Albert GAutomatic teat cup release device for milking machines
US2756959 *Jul 25, 1951Jul 31, 1956Globe CompanyFluid-pressure responsive sphincter valve
US2964285 *Jan 29, 1959Dec 13, 1960Soc D Ciments De Marseille EtDirect-passage valve
US2982511 *Feb 27, 1959May 2, 1961Connor Douglas MPressure-operated control valve
US3183908 *Sep 18, 1961May 18, 1965Samuel C CollinsPump oxygenator system
US3204631 *May 1, 1961Sep 7, 1965Louis G FieldsBlood oxygenator and pump apparatus
US3513845 *Sep 15, 1966May 26, 1970United Aircraft CorpBypass heart pump and oxygenator system
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3833013 *Apr 6, 1972Sep 3, 1974Baxter Laboratories IncSelf-valving fluid reservoir and bubble trap
US3849071 *Aug 27, 1973Nov 19, 1974K KayserBlood-gas separating system for perfusate circulation
US3889648 *Apr 4, 1973Jun 17, 1975Cav LtdFuel systems for engines
US3907504 *Apr 6, 1973Sep 23, 1975Gen ElectricBlood oxygenation system including automatic means for stabilizing the flow rate of blood therethrough
US3927980 *Aug 22, 1973Dec 23, 1975Baxter Laboratories IncOxygen overpressure protection system for membrane-type blood oxygenators
US3991768 *Jun 25, 1975Nov 16, 1976Portnoy Harold DShunt system resistant to overdrainage and siphoning and valve therefor
US4131431 *Dec 27, 1976Dec 26, 1978Siposs George GBlood shut-off valve
US4140635 *Apr 13, 1977Feb 20, 1979Esmond William GPurification device
US4515589 *Jul 5, 1983May 7, 1985Austin Jon WPeristaltic pumping method and apparatus
US4527588 *Dec 14, 1983Jul 9, 1985Warner-Lambert CompanySafety valve
US4684364 *Apr 12, 1983Aug 4, 1987Interface Biomedical Laboratories CorporationSafety arrangement for preventing air embolism during intravenous procedures
US4722725 *May 11, 1987Feb 2, 1988Interface Biomedical Laboratories, Inc.Methods for preventing the introduction of air or fluid into the body of a patient
US4877025 *Oct 6, 1988Oct 31, 1989Hanson Donald WTracheostomy tube valve apparatus
US4883461 *Nov 10, 1988Nov 28, 1989Interface Biomedical Laboratories Corp.Safety needle sheath in anti-reflux catheter having novel valve means
US5152964 *Feb 15, 1991Oct 6, 1992Minnesota Mining And Manufacturing CompanyMembrane blood oxygenator
US5161773 *Aug 1, 1990Nov 10, 1992Numed, Inc.Method and apparatus for controlling fluid flow
US5186431 *Mar 13, 1992Feb 16, 1993Yehuda TamariPressure sensitive valves for extracorporeal circuits
US5305982 *Dec 31, 1992Apr 26, 1994Yehuda TamariAdjustable static pressure regulator
US5378299 *Apr 5, 1993Jan 3, 1995M & D Balloons, Inc.Method of making a balloon with flat film valve
US5382407 *Oct 5, 1992Jan 17, 1995Minnesota Mining And Manufacturing CompanyMembrane blood oxygenator
US5482492 *Jan 10, 1994Jan 9, 1996M & D Balloons, Inc.Balloons and balloon valves
US5538002 *Oct 20, 1994Jul 23, 1996Boussignac; GeorgesDevice for respiratory assistance
US5595521 *Jun 7, 1995Jan 21, 1997M & D Balloons, Inc.Balloons and balloon valves
US6887220 *Sep 12, 2002May 3, 2005Gore Enterprise Holdings, Inc.Catheter having a compliant member configured to regulate aspiration rates
US7713247May 3, 2006May 11, 2010Icu Medical, Inc.Medical valve and method of use
US7713248May 3, 2006May 11, 2010Icu Medical, Inc.Medical valve and method of use
US7713249May 3, 2006May 11, 2010Icu Medical, Inc.Medical valve and method of use
US7717883May 3, 2006May 18, 2010Icu Medical, Inc.Medical valve and method of use
US7717884May 3, 2006May 18, 2010Icu Medical, Inc.Medical valve and method of use
US7717885May 3, 2006May 18, 2010Icu Medical, Inc.Medical valve and method of use
US7717886May 3, 2006May 18, 2010Icu Medical, Inc.Medical valve and method of use
US7717887May 3, 2006May 18, 2010Icu Medical, Inc.Medical valve and method of use
US7722575May 3, 2006May 25, 2010Icu Medical, Inc.Medical valve and method of use
US7722576May 3, 2006May 25, 2010Icu Medical, Inc.Medical valve and method of use
US8002765Aug 23, 2011Icu Medical, Inc.Medical valve with fluid escape space
US8034065 *Oct 11, 2011Ethicon Endo-Surgery, Inc.Controlling pressure in adjustable restriction devices
US8056582Nov 15, 2011Tandem Diabetes Care, Inc.System of stepped flow rate regulation using compressible members
US8105314Oct 25, 2007Jan 31, 2012Icu Medical, Inc.Medical connector
US8287495Oct 10, 2011Oct 16, 2012Tandem Diabetes Care, Inc.Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8298184Oct 30, 2012Tandem Diabetes Care, Inc.Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8398607Mar 19, 2013Icu Medical, Inc.Medical connector
US8408421Apr 2, 2013Tandem Diabetes Care, Inc.Flow regulating stopcocks and related methods
US8444628May 21, 2013Icu Medical, Inc.Needleless medical connector
US8448824Feb 26, 2009May 28, 2013Tandem Diabetes Care, Inc.Slideable flow metering devices and related methods
US8454579Jun 4, 2013Icu Medical, Inc.Medical connector with automatic valves and volume regulator
US8628515Mar 11, 2013Jan 14, 2014Icu Medical, Inc.Medical connector
US8650937Sep 18, 2009Feb 18, 2014Tandem Diabetes Care, Inc.Solute concentration measurement device and related methods
US8758306May 12, 2011Jun 24, 2014Icu Medical, Inc.Medical connectors and methods of use
US8758323Jul 29, 2010Jun 24, 2014Tandem Diabetes Care, Inc.Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8870850May 20, 2013Oct 28, 2014Icu Medical, Inc.Medical connector
US8926561Jul 29, 2010Jan 6, 2015Tandem Diabetes Care, Inc.Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8986253Aug 7, 2009Mar 24, 2015Tandem Diabetes Care, Inc.Two chamber pumps and related methods
US9186494May 2, 2014Nov 17, 2015Icu Medical, Inc.Medical connector
US9192753Jun 19, 2014Nov 24, 2015Icu Medical, Inc.Medical connectors and methods of use
US9205243Oct 21, 2014Dec 8, 2015Icu Medical, Inc.Medical connectors and methods of use
US9211377Jul 29, 2010Dec 15, 2015Tandem Diabetes Care, Inc.Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9238129Oct 27, 2014Jan 19, 2016Icu Medical, Inc.Medical connector
US9278206Apr 4, 2013Mar 8, 2016Icu Medical, Inc.Medical connectors and methods of use
US9314590 *Jun 14, 2011Apr 19, 2016University Of ManitobaMethod and apparatus for retroperfusion
US20040054348 *Sep 12, 2002Mar 18, 2004Michael HogendijkCatheter having a compliant member configured to regulate aspiration rates
US20040073174 *Jul 30, 2003Apr 15, 2004Lopez George A.Medical valve and method of use
US20040243070 *Jul 1, 2004Dec 2, 2004Lopez George A.Medical valve and method of use
US20060200086 *May 3, 2006Sep 7, 2006Lopez George AMedical valve with fluid escape space
US20060206058 *May 3, 2006Sep 14, 2006Lopez George AMedical valve and method of use
US20060264845 *May 3, 2006Nov 23, 2006Icu Medical, Inc.Medical valve and method of use
US20060264892 *May 3, 2006Nov 23, 2006Icu Medical, Inc.Medical valve and method of use
US20080029173 *Mar 30, 2007Feb 7, 2008Diperna Paul MarioVariable flow reshapable flow restrictor apparatus and related methods
US20080196762 *Apr 23, 2008Aug 21, 2008Scott MallettSystems and methods for the accurate delivery of flow materials
US20090217982 *Feb 28, 2008Sep 3, 2009Phluid Inc.Adjustable flow controllers for real-time modulation of flow rate
US20100032041 *Aug 8, 2008Feb 11, 2010Tandem Diabetes Care, Inc.System of stepped flow rate regulation using compressible members
US20100065578 *Oct 29, 2008Mar 18, 2010Diperna Paul MFlow regulating stopcocks and related methods
US20130296783 *Jun 14, 2011Nov 7, 2013University Of ManitobaMethod and apparatus for retroperfusion
USD644731Sep 6, 2011Icu Medical, Inc.Medical connector
DE3420861A1 *Jun 5, 1984Dec 5, 1985Biotest Pharma GmbhPeristaltic pump for medical purposes
EP0045668A1 *Aug 6, 1981Feb 10, 1982Peter Steer Developments LimitedDevice for controlling the flow of liquid
EP0701834A1 *Sep 6, 1995Mar 20, 1996Georges BoussignacRespiratory assistance device
WO1987004079A1 *Jan 27, 1986Jul 16, 1987Sawyer Philip NicholasMethods for preventing the introduction of air or fluid reflux into the body of a patient
WO1993018324A1 *Feb 10, 1993Sep 16, 1993Yehuda TamariPressure sensitive devices for extracorporeal pumping
WO2004024210A3 *Sep 10, 2003Jun 24, 2004Arteria Medical Science IncCompliant member for catheter to regulate aspiration rates
Classifications
U.S. Classification137/565.15, 137/844, 422/48, 251/5, 604/34
International ClassificationA61M1/36, A61M5/36, A61M39/22
Cooperative ClassificationA61M5/36, A61M39/228, A61M1/3621
European ClassificationA61M39/22H3, A61M5/36