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Publication numberUS3728739 A
Publication typeGrant
Publication dateApr 24, 1973
Filing dateFeb 23, 1971
Priority dateFeb 23, 1971
Also published asDE2208314A1
Publication numberUS 3728739 A, US 3728739A, US-A-3728739, US3728739 A, US3728739A
InventorsSemp B
Original AssigneeAmerican Cyanamid Co
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Sterile surgical gloves
US 3728739 A
Natural or synthetic rubber surgical elements such as tubing, catheters, drains and gloves are "lubricated" so as to prevent sticking during storage, and permit easier emplacement, such as putting on the gloves by a surgeon or nurse, by applying to the surface of the rubber element finely divided polyglycolic acid powder. The polyglycolic acid powder is readily absorbed by living tissue without deleterious tissue reaction, thus minimizing tissue reaction from the transfer of the powder from the element such as a glove to internal sites in a subject.
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Description  (OCR text may contain errors)

United States Patent Semp 1 Apr. 24, 1973 STERILE SURGICAL GLOVES 3,297,033 1/1967 Schmitt et a1 ..260/78.3 R 3,422,181 l/l969 Chirgwin ...260/78.3 R [75 1 Inventor" g Semi 3.468.853 9/1969 Schmitt et 3| "260/783 R [73] Assignee: American Cyanamid Company, Primary Examiner-G Larkln St f d Conn, Att0rneySamuel Branch Walker [22] Filed: Feb. 23, 1971 [57] ABSTRACT [2]] Appl' 117,998 Natural or synthetic rubber surgical elements such as Related Us. Application Dam tubing, catheters, drains and gloves are lubricated so as to prevent sticking during storage, and permit Continuation-impart of Sen 2, Oct easier emplacement, such as putting on the gloves by a surgeon or nurse, by applying to the surface of the rubber element finely divided polyglycolic acid [52] U.S.-Cl. ..2/l68, 260/783 R powden h l l fi d powder is readily [51] Int. Cl. ..A4ld sorbed by living tissue Without deleterious tissue reac- Field of Search tion, thus minimizing tissue reaction from the transfer 159 of the powder from the element such as a glove to internal sites in a subject. [56] References Cited 3 Claims, 2 DrawingFigures UNITED STATES PATENTS 2,621,333 12/1952 Thomas et a]. ..2/l68 l2 POWDERED POL YGL YC'OLL /C AC/D- 7'0 LUBE/GATE SURFACE I Patented April 24, 1973 3,728,739

/2 POWDERED POLYGLYCOLL/C AC/D- T0 LUBR/CATE SURFACE INVENTOR. BERNARD ALBERT SEMP LALWM ATTORNEY STERILE SURGICAL GLOVES RELATED APPLICATIONS This is a continuation-in-part of Ser. No. 770,792, filed Oct. 25, 1968, now abandoned in favor hereof.

BACKGROUND OF THE INVENTION This invention relates to a natural or synthetic rubber surgical glove which is lubricated with a biodegradable dusting powder, and to other rubber elements which contact raw tissue. Various dusting powders have been used on surgical gloves for years with a prime use being to facilitate insertion of the hands of operating room personnel into natural or synthetic rubber or latex gloves worn during surgery.

It is desirable that the powder on the gloves meet the following requirements:

1. It should be non-toxic to living tissue.

2. It should be biodegradable, i.e., absorbed by living tissue. This is most important since, during surgical procedures, powder almost inevitably falls or is rubbed from the surgeons gloved hand into an exposed body cavity, and may be carried from other areas of the operating room into the exposed body cavity by air currents.

3. The powder should have no adverse effect within the body such as the creation of lesions (i.e., adhesions, granulomas, or such). I

4. The glove powder must be capable of sterilization by convenient hospital techniques, preferably both autoclaving and gaseous ethylene oxide sterilization.

5. The powder must possess sufficient lubricity to permit ready insertion of the hand into the glove and must be of sufficiently fine particle size and have characteristics permitting such lubricity.

6. It must be reasonably priced and readily available.

7. It must be non-irritating to skin of both the surgeon or nurse and the patient.

Talc was among the earliest surgical glove powders used by the medical profession. However, after the report by Antopol (Lycopodium Granuloma, Arch. Path. 16, pg. 326 (1933)) that talc caused granulomas in the body, the use of talc as a glove powder was rapidly abandoned. Talc was replaced by starch glove powders since starch was known to be biodegradable and was not believed to cause granulomas or other aggravating conditions within the body. Currently, a widely used commercial surgical glove powder is specially treated homogeneous amylose which contains about 2 percent magnesium oxide to prevent clumping of the powder.

However, starch glove powders have a number of disadvantages. They offer high resistance to flow and they tend to gelatinize or agglutinate in the presence of hot water thereby creating problems when they are sterilized in a steam autoclave. Ordinarily, the starch must be treated in some way to minimize these properties. For example, as shown in U. S. Pat. No. 2,626,257, the starch may be treated with an agent, such as epichlorohydrin, which partially etherifies the starch in order to make the powder free flowing after steam sterilization.

Starch is also an excellent nutrient medium for virtually all vegetative bacteria such as various pathogenic microorganisms and is objectionable for that reason.

According to Lee and Lehman (Surgery, Gynecology, and Obstetrics 84, pgs. 689-695 (1947)), starch,

unlike talc, was completely absorbed within the peritoneal cavity without causing adhesions. This conclusion was challenged by Sneierson and Woo (Annals of Surgery 132, pgs. 1045-1050 (1955)) who reported two cases of large granulomas occurring in surgical wounds as a result of starch powder contamination. McAdams (Surgery 39, pgs. 329-336 (1936)) reported three-cases of intraperitioneal granulomas'caused by starch glove powder. The Saxens (Acta Pathology Microbiology Scand. 64, pgs. 55-70 (1965)) postulated that the magnesium oxide which acts as an anticlumping material was causing the lesions. Myllarniemi and Frilander (Journal of the International College of Surgeons 44, No. 6681, pgs. 677-681 (1965)) concluded that the harmful effects of starch glove powders containing magnesium oxide might be due to a combined effect of two irritating constituents. Other publications which indicate the serious concern of the medical profession over granulomas traced to starch glove powders are those of Lehman and Wilder (Journal of Abdominal Surgery 4, No. 3, pgs. 77-80 (1962)), Webb and Regan (Archives of Surgery 84, No. 3, pgs. 282-285 (1962)), and Walczak and Collura (American Journal of Surgery 103, No. 5, pgs. 611-612 (1962)).

Despite the aforementioned disadvantages associated with starch glove powders, they are still used by the medical profession due to the unavailability of an improved substitute.

It is clear that a dusting powder which is readily absorbed by tissue without deleterious interactions is desirable, and no powder meeting these requirements is obvious to the medical profession. The present powder meets all these requirements.

SUMMARY OF THE INVENTION This invention discloses a natural or synthetic rubber surgical glove having a lubricating coating of powdered polyglycolic acid, hereinafter abbreviated as PGA. The PGA of this invention is completely absorbed by living tissue within days with no observable adverse effects. In the course of biological degradation, the polyglycolic acid powder causes no significant formation of lesions such as adhesions or granulomas (see Example 3 hereinbelow). The powdered glove may be sterilized by autoclaving with no adverse effect upon its desirable properties such as, for example, its ability to flow freely without clumping (see Example 2). The powder can also be sterilized by other known methods such as, for example, gaseous ethylene oxide sterilization. The powder is non-toxic to living tissue, non-irritating to the skin and can be readily prepared synthetically.

There are also significant indications that when the powder of this invention is applied to living tissue, an

environment is created which is bactericidal or bacteriostatic. This is indicated by the ability of wounds deliberately infected with Staphylococcus aureus to heal with. no evidence of continuing infection when the wound has also been treated with the powder of this invention (see Example 4). It is further indicated by the failure of aqueous suspensions of the powder to support the growth of organisms such as Staphyloccoccus aureous (see Example 5). It is apparent that a medical dusting powder which is also bacteriostatic and bactericidal is a most desirable item.

poses larger quantities are deliberately introduced into i a wound site and the wound closed, polyglycolic acid is provides the medical profession with a synthetic powder which is absorbable by living tissue and which, furthermore, is non-toxic and gives no indication of causing lesions or other aggravating conditions to any substantial degree within the body. The powder is readily sterilized by autoclaving or ethylene oxide vapor and requires no elaborate pre-treatment of the powder to prevent it from clumping during such sterilization treatments.

Natural rubber or synthetic rubber surgical elements have many uses. Probably the most common is that ofa rubber glove used by a surgeon or nurse during a surgical procedure or examination ofa patient. Other sterile surgical elements may be used such as catheters, or rubber drainage tubes which are placed in the site of a wound to permit drainage during the healing process. Such drains are often removed as soon as the healing process proceeds to the point that a discharge is no longer occurring. Whether the surgical elements such as a drainage tube is to remain in the patient for a matter of several days or whether it is a surgical glove which is to be in contact with the raw tissues of a wound for only a period of a few minutes, any powder on the surface of the rubber may be transferred into the subject. Foreign elements in tissue usually cause adverse reactions. The degree of the adverse reaction can vary over a wide limits but even though the reaction may be minimal, it is desired that it be reduced as far as possible.

To prevent rubber elements from sticking to each other for example the turns of a rubber tube or the folds of a surgical glove, it is desirable that the surface be. coated with a finely divided powder to impart lubricity. Lubricity is particularly necessary with a surgeons glove in order that the glove may be easily donned.

Obviously, it is highly desirable that any such lubricating powder be completely non-irritating to the living tissues of the subject. Although the desirability of an inert powder which is completely absorbable has been recognized, a powder which would meet the requirements of lubricity and still be completely absorbable with a minimal tissue reaction under any and all conditions has not been obvious to the medical profession.

It has now been found that finely divided polyglycolic acid imparts the desired lubricity to rubber and if present in a wound appears to be completely absorbed by living tissue within a surgical acceptable period of time. When used as a suture, polyglycolic acid is completely absorbed in less than 90 days in normal muscular tissue. Polyglycolic acid dusting powder whether on a drainage tube which is left in a wound or on a glove which is transferred into the wound, is normally present in the wound in but small quantities and appears to be completely undetectable in far less than 90 days. Whereas the quantities which would rub off in the wound are comparatively small, when for test purabsorbed with minimal tissue reaction.

Additionally, the polyglycolic acid is an acid and as such has a low pH, which low pH is not favorable to the growth of deleterious microorganisms, so that up until the acidity of the polyglycolic acid is neutralized by contact with other materials, the growth of microorganisms is at least partially inhibited.

Although surgical elements other than surgeons gloves do have considerable use, the biggest use is that of the dusting powder for the surface of the surgeons glove. Therefore the present invention will be described in greatest detail in connection with such gloves, having a coating of lubricity imparting polyglycolic acid. 7

Because the polyglycolic acid to be used on the surface of the rubber gloves and other rubber goods as a dusting powder need not be mechanically strong, and may in fact be somewhat elastic, a copolymer of polyglycolic acid containing lactic acid moieties, as for example, by the copolymerization of polyglycolic acid and lactic acid is acceptable. Usually a copolymer tends to be more elastic or rubbery than a homopolymer. Where maximum strength is desired,

frequently a homopolymer has unique characteristics, but in a powder such as here where tensile strength is not a criteria, a copolymer gives good lubricity. Also the production techniques required for maximum tensile strength which are advantageous where polyglycolic acid is used as a suture, are not necessary in a glove powder as inthe glove powder, the lubricity is the key feature and if the rubber glove having the dusting powder on its surface permits readygloving, that is permits the surgeon to insert his hand into the glove readily, with the glove sliding onto his hand even if somewhat moist, in such fashion as to give the feel to which the surgeon is accustomed, the powder has filled its requirements. It is of course necessary that the'glove slide on the surface of the skin of the surgeon sufficiently that the thin rubber membrane does not interfere with the sensitivity of the surgeons fingers so that the surgeon may readily feel through the glove.

Polyglycolic acid in the form of a suture has a tensile strength that compares favorably with that of steel on a size basis and on a weight basis compares favorably with alloy steel but as a lubricant in connectionwith surgical glove, the strength requirements are such that batches of polyglycolic acid which do not meet the tensile strength requirements of a suture may be pulverized and used as a perfectly satisfactory glove powder.

DRAWINGS In the drawings:

FIG. 1 is a surgical glove having on the surface thereof polyglycolic acid.

FIG. 2 shows a user donning a surgical glove.

DESCRIPTION OF THE PREFERRED EMBODIMENTS The inventive dusting powder may be prepared by grinding or otherwise pulverizing polyglycolic acid to the desired particle size by the use of conventional grinding equipment and techniques well known to those skilled in the art. For example, polyglycolic fiber or filament as prepared in U. S. Pat. No. 3,297,033 is placed in an ordinary ball mill and ground for periods of anywhere from to 48 hours. The grinding equipment is preferably grounded during the grinding operation to prevent undesirable aggregation of the particles caused by the static electrical charges which can accumulate on the particles during grinding. The ground material can then be removed from the mill and vibrated through a series of screens of varying mesh mounted on a Ro-Tap testing sieve shaker as supplied by W. S. Tyler Co.

Particle size of the ground polymer is an important criteria in selecting a powder which is suitable for a glove powder.

It is desirable that all the powder particles be small enough to pass through a 100 mesh screen 149 micron designation in the U. S. Sieve Series). However, small amounts (up to about 1 percent by weight) of somewhat larger sized particles can also be present in the powder without unduly adverse effect on the lubricating properties of the polyglycolic acid powder. It is preferred that all of the powder particles pass through a 200 mesh screen (74 micron designation in the U. S. Sieve Series). Passage through such a screen indicates the particles contain no dimension exceeding about 74 microns.

in preparing the glove powder it is equally important that it not be made too fine in order to minimize the escape of excessive powder into the environment in the course of powdering the hands, surgical gloves, or other items. As discussed heretofore, the powder, on the other hand, should not be of an excessively large particle size nor should it contain substantial amounts of exceptionally large particles since this will create an undesirable abrasive effect upon the skin of the hand when the powder is used. A suitable particle size range is from about 0.5 to about 149 microns with a range of from about 10 to microns preferred.

When polyglycolic acid powder is to be sterilized in an environment which contains substantial amounts of water such as, for example, in an autoclave, it is essential that the powder be contained within a package which is substantially impervious to the water or steam. If this precaution is not taken, the water can hydrolyze the polymer causing it to become gummy and sticky. A particularly suitable water impervious container is the laminate of Mylar and polyethylene such as that described in U. S. Pat. No. 2,949,181, said patent being herein incorporated by reference. When polyglycolic acid is packaged in a water impervious container such as that described above, it can be autoclaved and still retain the free flowing properties required ofa medical dusting powder (see Example 2).

Glove powder is used in a variety of ways by the medical profession. Rubber surgical gloves are typically sold unsterile in pairs with a package of glove powder inserted in the cuff of one of the gloves. When it is desired to use the gloves, the gloves and the package of glove powder are sterilized, usually by autoclaving. The surgeon will then open the package of glove powder (the package usually contains about 1.5 grams of powder) and pour the powder onto his hands. After working the powder over the surface of his hands, the surgeon inserts his powdered hands into the surgical gloves, the glove powder providing the lubricity required to facilitate this insertion. in cases where the gloves are reusable, the gloves, at the end of the operation, will be washed, dried, inspected for holes and then repowdered, usually on both the internal and external surfaces of the glove for subsequent reuse of the glove.

. This powdering is ordinarily accomplished by placing the gloves and a prescribed amount of glove powder in a tumbler and tumbling for a sufficient period of time to powder the inside and outside surfaces of the glove. The powdered gloves are then repackaged, autoclaved, and presented to the surgeon for use. Since the outside of the glove is often powderedit is readily apparent how some of the powder may spill off the glove and into the exposed surgical cavity ofa patient.

Disposable surgical gloves usually made of latex are also available to the medical profession. These gloves can be offered as a unit of one pair of gloves and one package of glove powder contained in a suitable package. However, they are ordinarily offered as a powdered glove, i.e., the inner and outer surfaces of the glove are pre-powdered with a suitable dusting powder. When the contents of the envelope, i.e., the gloves and the powder are sterile, the entire envelope must first be autoclaved or otherwise sterilized. At the end of the operation the gloves are discarded.

Typical glove packages are described in U. S. Pat. Nos. 3,107,786 and 3,181,695.

The gloves of the present invention may be sealed in a strippable enclosure of the type shown in U. S. Pat. No. 2,949,181, there described for sutures, but adaptable to surgical gloves.

From the foregoing it becomes apparent that the glove powder of this invention can be offered either separately in a single package of a suitable material or in combination with a pair of surgical gloves in either a sterile or unsterile condition. The powder itself may be either sterile or non-sterile.

It is desirable when a sterile powdered surgical glove, sterile powder, or a sterile combination of a surgical glove and separately packaged glove powder is to be offered, to package the aforementioned sterile items in a sterile inner enclosure which is then packaged in a sterile outer enclosure. The outer enclosure is provided with a strippable seal, which then allows for convenient serving of said sterile item to the potential user by merely stripping away the outer enclosure to present a totally sterile enclosure, i.e., the outer surface as well as the contents of the inner enclosure are sterile, containing the sterile item to the user. The user can then open the package and remove the sterile item therein without risk of contaminating the contents from contact with the outer surface of the inner enclosure.

The following examples are provided to further illustrate the invention.

EXAMPLE 1 PREPARATION OF POLYGLYCOLIC ACID LUBRICATING POWDER Polyglycolic acid filaments such as typically prepared by the teachings of U. S. Pat. No. 3,297,033 were placed in a Wiley Mill and ground for several hours. The ground product consisted of chopped pieces of filament ranging from 2 to 4 mils in width and 12 to 20 mils in length. The particles were flat rather than cylindrical in shape and fibrillated.

The product ground on the Wiley Mill was then ball milled for 3 hours and examined microscopically to determine if a further breakdown in size had occurred. Acicular particles were found ranging in size from 0.5 micron to large fragments of the chopped filaments.

Ball milling of the product was continued for another hours. At this point, more than 90 percent of the ground material passed through a 7 mil sieve opening and the bulk of this material was found to have a particle size ranging from less than 0.5 micron to 15 microns. The larger sized material which passed through the 7 mil sieve was either acicular with a diameter in the aforementioned range or static aggregates. The powder retained by the 7 mil sieve was discarded.

EXAMPLE 2 STERILIZATION OF POLYGLYCOLIC ACID DUSTING POWDER The powder prepared in Example 1 was placed in a transparent envelope fabricated from a laminate of the polymeric ester of ethylene glycol and terephalic acid (Mylar) and polyethylene. Such a laminate is available commercially from the Minnesota Mining and Manufacturing Co. Under the name Scotch-Pak. This laminate is known to resist penetration by water in either liquid or vapor form. The particular laminate employed had a Mylar thickness of about 1.1 to 15 mils and a polyethylene thickness of about 3 to 3.5 mils. The polyethylene layer of the laminate forms the inner surface of the package to facilitate heat sealing of the package.

The package was then heat sealed and placed in a standard autoclave l 5 psig steam pressure, 250F.) for 1 hour. The package was then removed and opened. The package contents were free flowing and gave no indication of being tacky or sticky. The powder was applied to the hands of a subject who then proceeded to glove his hands with a pair of rubber surgical gloves. The performance of the powder in facilitating insertion of the hands into the gloves was quite satisfactory. Continued wearing of the gloves indicated that the powder was non-irritating to the skin.

EXAMPLE 3 IN-VIVO COMPARISON OF THE LESION PRODUCING PROPERTIES OF STARCH AND POLYGLYCOLIC ACID DUSTING POWDER Lateral incisions were made through the peritoneal wall on both sides of two albino New Zealand female rabbits. On one side, a 5 percent solution of sterile saline and the polyglycolic acid powder prepared in Example l was placed on the peritoneal wall. On the other side was placed an identical solution of a widely used commercial starch powder.

The rabbits were sacrificed after 3 months and gross and histological examinations of the peritoneal wall were made for, and of, any lesions which were present. The portion of the wall treated with polyglycolic acid powder was substantially free from lesions except for the presence of a few small nodule granulomas. The portion of the wall treated with the starch powder, however, contained numerous readily apparent lesions and contained several granulomas and a large adhesion.

The above results indicate that reduced formation of lesions can be expected when the polyglycolic acid powder of this invention is used compared to the currently used starch powder.

EXAMPLE 4 IN-VIVO BACTERIOSTATIC AND BACTERICIDAL PROPERTIES OF POLYGLYCOLIC ACID POWDER Two ventral incisions were made in two albino New I Zealand female rabbits. Both incisions were deliberatepowder appears to have in-vivo bacteriostatic and bactericidal properties.

EXAMPLES IN-VITRO BACTERIOSTATIC AND BACTER- ICIDAL PROPERTIES OF POLYGLYCOLIC ACID POWDER Four grams of polyglycolic acid powder as prepared in Example I were added to 80 cc. of water. The pH of the resulting suspension was slightly less than 2. 10 cc. of this suspension were placed in a test tube labeled No. l. The pH of the remaining cc. was raised to 6 by adding approximately 0.5 gm. of sodium bicarbonate. 10 cc. of the pH 6 suspension was placed in test tube No. 2. The pH of the remaining 60 cc. was raised'to 7 by adding approximately 0.4 gm. of sodium bicarbonate. 10

cc. of the pH 7 suspension was placed in test tube No. 3. Test tube No. 4 contained deionized water.

0.5 cc. of a 48 hour nutrient broth suspension of Staphylococcus aureus were added to each of the 4 test tubes. The tubes were incubated at 37C. for 24 hours.

At this point, 0.4 cc. of each tube were removed and transferred to agar pour plates. These plates were incubated at 37C. for 48 hours. Results are shown below:

Tube No. pH Result 1 2 No Growth 2 6 Moderate Growth 3 7 Heavy Growth 4 Heavy Growth The above results show that aqueous suspensions of polyglycolic acid powder have in-vitro bacteriostatic and bactericidal properties. The acid pH is an important factor on gloves or in a wound, until the pH is increased, the environment'is not favorable for many microorganisms.

EXAMPLE 6 Powdered Gloves A group of freshly dipped latex gloves as manufactured and before dusting were placed in a drum with about 1 gram per glove of the dusting powder of Exampie 1. The gloves were tumbled and shakened till the gloves were uniformly coated with the powder afterwhich the gloves were shaken to remove excess powder, paired and folded and then placed between two sheets of a laminate of polyester film and polyethylene. The material is described in detail in U. S. Pat. No. 2,949,181. The laminate was sealed polyethylene to polyethylene, leaving a lip and a strippable seal as described in said US. Pat. No. 2,949,181 and then a group of the packaged gloves were placed in an autoclave and heated to sterilize temperature.

As so produced, the gloves could be released by stripping the package, to release the gloves in sterile condition and were then ready to be donned by a user.

EXAMPLE 7 A group of the gloves dusted with powdered polyglycolic acid as described in the preceding example were sealed between a polyester, polyethylene laminate as above described using a strippable seal and a group of the gloves were then placed in a ethylene oxide chamber to allow the ethylene oxide to penetrate through the laminate sea] as described in more detail in US. Pat. No. 2,917,878 Canarius and Kaufman.

The individual gloves before sterilization are indicated in FIG. 1, the surface of the glove 11 has powdered polyglycolic acid 12 spread thereover.

FIG. 2 shows the surgeon donning the glove. The glove 13 is held by a nurse whose hands 14 hold the glove with the cuff slightly stretched while the hand of the surgeon 15 is inserted therein to.

lt is convenient to powder the glove with the finely divided polyglycolic acid before the glove is sterilized, and sterilize the powdered glove and keep it in sterile condition until ready for use. It is also convenient to use the powdered polyglycolic acid in sterile form to be applied to the surface of sterile gloves at the time they are being put on. The time of powdering the glove and the time for storing can vary with the technique and schedules of the particular user, such as a hospital or individual surgeon. If sterile gloves are used, a single use disposable glove is convenient. If the gloves are to be reused, the time of applying the powder and the sterilizing can be varied depending upon the number of gloves used in the inventory available or preferences.

of 0.5 to 149 microns.

3. The glove of claim 2 in which the glove and powder are sterile, and the powder is homopolymeric polyglycolic acid which will pass through a 200 mesh screen.

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Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3810458 *Apr 10, 1973May 14, 1974American Cyanamid CoMinimizing tissue reaction to glove powder
US3872515 *Aug 17, 1973Mar 25, 1975Dow CorningRubber gloves
US3942193 *Mar 27, 1975Mar 9, 1976Akwell Industries, Inc.Dental glove
US4059097 *Nov 3, 1976Nov 22, 1977American Cyanamid CompanyMethod of minimizing tissue reaction during surgery with chitin
US4064564 *Nov 3, 1976Dec 27, 1977American Cyanamid CompanyChitin derived surgical glove powder
US4068757 *Nov 3, 1976Jan 17, 1978American Cyanamid CompanyChitin derived powder in sterile surgical element package
US4499154 *Nov 30, 1982Feb 12, 1985Howard L. PodellDipped rubber article
US4540407 *Nov 14, 1983Sep 10, 1985Dunn Robert NSurgical gloves and surface treatment of surgical gloves for avoiding starch peritonitis and the like
US4575476 *Nov 28, 1983Mar 11, 1986Howard I. PodellSurgeon's gloves
US4836186 *Jan 16, 1987Jun 6, 1989Scholz Francis JBody compression device for patients under fluoroscopic examination
US4845780 *Apr 13, 1988Jul 11, 1989Becton, Dickinson And CompanyGlove having improved cuff securing features
US4911974 *Jul 5, 1988Mar 27, 1990Toray Silicone Company, Ltd.Tack-free silicone gel moldings
US5467481 *Jul 15, 1994Nov 21, 1995Srivastava; Laxmi S.Glove with hand-coloring material
US5467483 *Jan 7, 1994Nov 21, 1995Saadatmanesh; HamidSurgical glove with removal means protected from contamination
US6242042Sep 14, 1998Jun 5, 2001Lrc Products Ltd.Immersion in aqueous solution of hydrophilic resin
US6706313Sep 14, 1999Mar 16, 2004Lrc Products Ltd.Immersing article in aqueous solution of 2-hydroxyethyl acrylate- 2-hydroxyethyl methacrylate co- or terpolymer, heat curing and vulcanizing rubber or latex
US8257388 *Dec 29, 2004Sep 4, 2012Sutureaid Holdings B.V.Surgical instrument and method
EP0300814A2 *Jul 22, 1988Jan 25, 1989JOHNSON & JOHNSON MEDICAL, INC.Antimicrobial medical glove
U.S. Classification2/168, 528/361, 528/354
International ClassificationA61B19/02, A61B19/00, A41D19/00, A61B19/04
Cooperative ClassificationA41D19/0058, A41D19/0096, A61B2019/0219, A61B19/04
European ClassificationA41D19/00P2, A41D19/00P10R, A61B19/04