|Publication number||US3730186 A|
|Publication date||May 1, 1973|
|Filing date||Mar 5, 1971|
|Priority date||Mar 5, 1971|
|Publication number||US 3730186 A, US 3730186A, US-A-3730186, US3730186 A, US3730186A|
|Inventors||L Edmunds, S Braley|
|Original Assignee||Univ Calif|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (5), Non-Patent Citations (2), Referenced by (157), Classifications (14)|
|External Links: USPTO, USPTO Assignment, Espacenet|
1 United States Patent 1 Edmunds, Jr. et al.
 ADJUSTABLE IMPLANTABLE ARTERY-CONSTRICTING DEVICE  Inventors: Louis Henry Edmunds, Jr., Piedmont, Calif.; Silas A. Braley, Midland, Mich.
 Assignee: The Regents of The University of Calif., Berkeley, Calif.
 Filed: Mar. 5, 1971  Appl.N0.: 121,406
 US. Cl. ..128/325, 128/327, 128/346, I 128/DIG. 25  Int.Cl. ..A6lb 17/12  Field ofSearch ..128/325, 326,327, 128/344, 346, DIG. 25
 References Cited UNITED STATES PATENTS 3,527,220 9/1970 Summers ..128/260 3,538,917 11/1970 Selker ..128/326 3,447,570 6/1969 Collinsm. ....l28/2l4RX 2,455,859 12/1948 Foley....... ....l28/346 7 3,176,690 4/1965 HDoubler ..128/348 OTHER PUBLICATIONS In Vivo Metric Systems Bulletin, March 1968, 2 shts. of Bulletin. Khouri et al., Jour. of Applied Physiology. Vol. 23 No.
V 11] 3,730,186 51 May 1, 1973 3, Sept. 1967, pp'. 395-397.
Primary Examiner-Dalton L. Truluck Attorney-Owen, Wickersham & Erickson 57 ABSTRACT A device, completely implantable within the human body, for restricting the flow of blood through a major blood vessel, such as an artery, especially the pulmonary artery. An inflatable, flexible annulus, generally circular in shape but not a closed circle, has a nondistensible outer wall so that upon inflation all distention or expansion is inward. The device is placed around an arteryor other blood vessel, and the ring may then be closed, as by suturing together preformed tabs attached to the annulus, or by suturing together the ends of an overlapping tape, for instance, to firmly hold the vessel. Upon inflation, inward distention of the inflatable annulus constricts the vessel, and flow of blood therethrough is accordingly restricted. Inflation and deflation are effected through a self-sealing hollow bulb and a non-distensible tube connecting the bulb to the interior of the inflatable annulus, pressure fluid being introduced into the bulb by a fine hypodermic needle. The device may be wholly contained within the patients body, and all surfaces thereof are of a substance, such as a medical elastomer, that is compatible with and resistant to the action of body fluids.
6 Claims, 5 Drawing Figures Patented May 1, 1973 I 3,730,186
INVENTORS LOUIS HENRY EDMUNDS, JR. SI L AS A. BRALEY ATTORNEYS ADJUSTABLE IMPLANTABLE ARTERY- CONSTRICTING DEVICE BACKGROUND OF THE INVENTION blood flow through the pulmonary artery. The device is suitable for prolonged use within the human body, i.e., for months or even years of such use.
The invention described herein was made in the performance of work under a research grant from the United States Public Health Service.
It has been recognized that approximately eight babies per thousand have congenital heart disease, and, of these, four have greater than normal pulmonary arterial blood flow. Such mechanical defects have led to attempts to develop a safe, reliable, adjustable device to effect arterial banding. Attempts previously have required that mechanical control be applied from outside the body, as by a screw device to manipulate a tape encircling a blood vessel, and heretofore no such device has been capable of being implanted in the body for permanent or at least long-term use.
The present invention provides a device for arterial banding and mechanical restriction of blood flow through an artery, or other major blood vessel. It is safe, is compatible with body fluids, and is controllable externally while being totally contained within the patients body. An advantage of the present invention is that the device is adjustable to conform to the size of the artery being banded and can be permanently emplaced, while yet periodic adjustments continue to be possible, as desired. Furthermore, the device is wholly implanted in the body and yet is later controllable without surgery. Further advantages are that adjustments can easily be made in the amount of inflation to accommodate for somatic growth, pulmonary pressure can be determined with the aid of this device, the band or annulus can be easily reached in order to close it upon emplacement and the connecting tube is short and non-twisting thus preventing interference in any desired flow of liquid.
SUMMARY OF THE INVENTION The present invention provides, in combination 1) an unclosed annulus or doughnut ring, capable of inward distention only, (2) a non-distensible bulb, (3) a non-distensible tube connecting the bulb to the annulus, and (4) means to control penetration by a later-inserted needle or the like and to protect the bulb from undesired punctures.
The annulus is shaped to form an unclosed circle, the circle being left open to enable insertion around an artery. The annulus is closed at both ends and has a distensible inner wall and a non-distensible or substantially non-distensible outer wall. The small non-distensible tube is affixed to the outer wall of the annulus at any convenient point and provides a conduit in open communication with the interior of the annulus through a suitable aperture in the outer wall of the latter. At the end of the tube distant from the annulus is the bulb, which is used to pump fluid through the conduit and into the banding annulus, thereby inflating the annulus and distending the inner wall. The distending of the inner wall exerts pressure on the enclosed portion of the artery or other blood vessel and completely or partially restricts the flow of blood therethrough.
The purposes of having a non-distensible outer wall of the annulus are (1) that the effect of inflation of the annulus be directed substantially entirely inwardly toward the enclosed artery, and (2) that any pressure on the surrounding body structure be avoided or minimized. The desired restraint on the outer wall can be effected in any desired manner, one advantageous means being to affix thereto a reinforcing layer of Teflon (tetrafluoroethylene) tape.
The banding annulus can be made in several sizes to accommodate different situations or needs. For instance, annu li can be supplied in various internal diameters of from about 1.0 cm. to 3.0 cm., e.g., in steps of 0.5 cm. of intervals, the diameters being measured when the annuli are uninflated.
The tube that connects the interior of the annulus to the interior of the bulb is not distensible and is suitably made of Dacron or possibly of hard, non-distensible medical elastomer, such as silicone rubber. The hollow bulb is also not distensible and can be made from the same or similar material. The volume of this bulb is suitably about from 3 to 6 ml. A sink or pan of suitable body-compatible metal, e.g., titanium, and having a base and a side wall conforming to the interior shape of the bulb is disposed within the base of the bulb and facilitates location of the injection chamber with a needle and prevents perforation of the floor or lower wall of the bulb itself. This will be further explained in the more detailed description below. In the insertion or emplacement of the device, the bulb is preferably disposed on the sternum just underneath the patients skin, where it can be readily located by palpation and inflated by means of a needle inserted through the skin.
The interior of the ring, tube and bulb are in open communication with each other and are self-sealing, and they must not leak. All surfaces of such a device to be wholly implanted in the body are made of a substance compatible with and resistant to the action of body fluids. Such a substance is suitably a medical elastomer such as silicone rubber, of varying degrees of hardness or cure to accommodate the need for distensible or non-distensible portions.
BRIEF DESCRIPTION OF THE DRAWINGS The invention and an advantageous mode of carrying it out are illustrated by the following description and by the annexed drawings, wherein:
FIG. 1 is a view in front elevation of an embodiment of an implantable pulmonary arterial band with the annulus partially inflated; the inner periphery is shown deflated in a broken line. Y I
FIG. 2 is a view in side elevation of the band of FIG. 1.
FIG. 3 is a view in section taken. on the line 3-3 of FIG. 1 of an inserted inflated annulus and its relationship to an enclosed artery.
FIG. 4 is a somewhat schematic view in side elevation of the device in place around the pulmonary artery of a patient.
FIG. 5 is a cross-sectional view of an embodiment of a non-distensible bulb of a device according to this invention showing the interior elements.
DETAILED DESCRIPTION OF THE INVENTION For purposes of illustration only, the invention is illustrated by the device shown in the accompanying drawings.
This device is a pulmonary arterial band or extravascular occluder and comprises an inflatable nonclosed ring or annulus of flexible material to enable its introduction around an artery to enclose it, a connecting tube 11 and a bulb 12. Each of these components is made of or covered by material which is nontoxic and resistant to attack by body fluids, i.e., does not deteriorate within the body, because the entire device is to be implanted.
The annulus 10 includes an inflatable or balloon inner portion 13 which is formed from a medical elastomer and is flexible and distensible. Preferably, it is made from or includes a selfsealing latex or elastomer. An advantageous type of such elastomer is the silicone rubber widely available in commerce in medical grades. The annulus 10 is in the form of an incomplete or non-closed ring or circle, having two closed, sealed ends 14 and 15 forming an opening 16 therebetween. The outer wall 17 of the annulus 10 is reinforced so that it is not distensible when internal fluid pressure is applied although it, too, remains flexible. This reinforcement can be accomplished in one embodiment as shown by incorporating or embedding a fabric 18, such as nylon or Dacron mesh or cloth, within the outer portion 17 of the silicone rubber annulus 10. The curvature of the casing or annulus 10 helps to direct the non-reinforced inflatable or balloon portion 13 inwardly as it is inflated and to prevent rolling or distortion of such portion 13. An advantageous method of incorporating the fabric 18 in the annulus 10 is to form a coating piece or tire, of the required size and curvature, of such fabric molded into silicone rubber and to weld such tire to the outer surface of an inflatable tube of medical rubber.
The connecting tube 11 can be made from a harder, non-distensible silicone rubber, or of Dacron-reinforced silicone rubber, so that it remains of constant dimensions under the pressures to be, applied. It is relatively short and relatively thick-walled so as to be twistresistant and non-kinking. That is, the wall thereof may be from 0.062 to 0.065 inch thick and the tube is of such length as to extend in a substantially straight path, i.e., without curling upon itself, from adjacent the inner surface of the skin to the blood vessel to be treated. For example, the tube so extends from the sternum to the pulmonary artery area, in one embodiment, and is about four inches long. The tube 11 connects with a suitable aperture in the reinforced casing portion 17 and debouches into the interior of the annulus 10, being sealed thereto to prevent leakage. At the end remote from the annulus 10, the tube connects with a suitable aperture in the bulb 12 similarly and is also sealed thereto. Advantageously, the tube 11 connects tangentially to the outer surface of annulus 10, which provides for smoother flow of liquid therethrough and makes easier the placement of the annulus 10 relative to the artery.
The bulb 12 can be formed of a flexible, nondistensible and self-sealing elastomer, such as a suitable reinforced or non-reinforced silicone rubber. It is adapted to being punctured and filled or emptied ofa pressureproviding fluid, such as 0.9 percent aqueous saline solution, by using a very fine hypodermic needle, e.g., a No. 22 or 25 needle. Upon withdrawal of the needle the bulb l2 seals itself. This result may be advantageously obtained by providing a bulb 21 of a self-sealing elastomer. In one advantageous embodiment, the bulb 21 contains an upper chamber 26 and a lower chamber 27 separated by an impervious diaphragm 28. Upper chamber 26 contains silicone gel 29, which acts to seal any puncture in bulb 21 caused by insertion of the liquid-injecting needle.
Disposed in lower chamber 27, fitting snugly therein and substantially covering the base and side walls thereof, is a metal sink or pan 30 having a base 31, a side wall 32, and an aperture 33 in the base 31 registering with the central passage 34 in the tube 1 1. A baffle 35 is spaced from the base 31 by a plurality of legs 36 to provide free flow of liquid into and from the passage 34. In this manner, location of the receptacle for injected liquid is facilitated during such operation and the bottom and side walls of the bulb are protected by the metal from punctures due to insertion of the needle. The diaphragm 28 is suitably extended beyond the exterior wall of the bulb 12 to provide a sewing flange 37. Advantageously aperture 33 can be in the form of a plurality of small holes arranged to form a pattern to register with the interior of tube 11 and to be protected by baffle 35. The elastomer bulb 21 is then provided with a protective coating 22 of silicone rubber which is reinforced with Dacron mesh or the like. Suitably, diaphragm 28 with its flange portion 37 is also of such reinforced rubber. There are also sometimes provided a pair of diametrically disposed anchor or sewing tabs 38, 39, preferably disposed transversely or at right angles to the direction of curvature of the annulus 10 and affixed to its outer surface to enable suturing to adventitia of the artery so that the device remains in stable position on the artery being treated.
In using the device of this invention, the pulmonary artery 40 is made accessible by suitable, known surgical procedures, and the artery 40 is inserted within the annulus 10 by way of the opening 16, which may be pulled apart or enlarged as necessary, the ring 10 being quite flexible. After placement of the artery 40 in the annulus 10, ends 24 and 25 of annulus 10 which extend beyond closed ends 14 and 15 thereof may be trimmed if necessary by the surgeon and are then sewn together, suitably using heavy ligatures. The bulb 12 is placed on top of the sternum (not shown) just below the skin where it can be located later by palpation and easily reached by a hypodermic needle to fill or empty the bulb l2 and, through it and connecting tube 1 1, the annulus l0 and the inflatable annulus 10, to inflate and force inwardly distensible portion 13 to constrict the artery 40 as desired, as shown in FIG. 3. The incision in the patient is then closed by the surgeon in the usual manner, the implanted device remaining entirely subcutaneously disposed.
In use of the device after it is emplaced and any incision closed, the hollow bulb 12 is located by palpation and is filled by means of a hypodermic needle, as noted above, introducing a fluid such as 0.9 percent aqueous saline, which flows through the connecting tube 11 into the hollow interior of the annulus 10 causing the inner wall 27 to distend and constrict the artery 26, reducing flow of blood therethrough. The flow of pressure fluid can be aided by manual pressure on the bulb 12. Fluid can be withdrawn, when desired, also by means of a needle. In each case the interior layer of the bulb l2 seals itself, as described.
It will be understood that the above specific description and the drawings have been given for purposes of illustration only and that variations and modifications can be made therein without departing from the spirit and scope of the appended claims. For instance, instead of a permanently fluid pressure substance, the bulb 12 can be filled with a fluid plastic mixed with a catalyst which will cause it to harden in a predetermined time after it fills the inflatable element.
Having described the invention, what is claimed is:
1. A totally implantable adjustable extravascular occluding band adapted to restrict flow of blood through an artery or other major blood vessel, including in combination:
a flexible, inflatable annulus having an incomplete unclosed, generally circular shape, having two ends, each of which is closed, and having a hollow interior, a distensible inner wall, and a non-distensible outer wall, said inflatable annulus forming an artery-receiving space bounded by said inner wall, having a hollow interior and being adapted to penetration by a hypodermic needle, and comprising an upper chamber, a lower chamber, an impervious diaphragm separating said chambers, silicone rubber gel disposed in said upper chamber,
shield means in said lower chamber to protect said lower chamber from penetration by a needle, said shield means being a metal sink having a bottom and a side wall, said sink fitting snugly within said lower chambersubstantially covering the side wall and base of said chamber, and having an aperture in said bottom registering with the central passage of a flexible connecting tube, and
a non-distensible flexible, twist-resistant tube having a central passage providing a conduit between the interior of said bulb and said hollow interior of said annulus.
2. The band of claim I wherein said diaphragm extends to form an annular flange around said bulb.
3. The band of claim 1 wherein said metal is titanium.
4. The band of claim 1 having a baffle in said sink spaced from and protecting said aperture.
5. The band of claim 1 wherein said sink has an aperture of a plurality of small holes arranged in a pattern to register with said central passage.
6. In an adjustable occluding band adapted to be totally implanted in a human body and to restrict flow of blood through an artery or other major blood vessel, and comprising generally a flexible, inflatable, hollow annulus adapted to receive an artery or other major blood vessel, a needle-penetrable bulb and a nondistensible flexible tube connecting the interior of said annulus and the interior of said bulb,
the improvement wherein said bulb is non-distensible and self-sealing and comprises an upper chamber, a lower chamber an impervious diaphragm separating said chambers, a shield means in said lower chamber to protect said lower chamber from puncture by a needle, said shield means being a metal sink having a bottom and a side wall, said sink fitting snugly within said lower chamber substantially covering said side wall and bottom of said chamber, and having an aperture in said bottom registering with the central passage of said flexible tube, and means to anchor said bulb within said body.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2455859 *||May 13, 1946||Dec 7, 1948||Frederic E B Foley||Artificial sphincter and method|
|US3176690 *||May 26, 1961||Apr 6, 1965||Doubler Peter B H||Catheter having integral, polymeric flanges|
|US3447570 *||Nov 1, 1967||Jun 3, 1969||Collins Robert M||Puncture pad and holder|
|US3527220 *||Jun 28, 1968||Sep 8, 1970||Fairchild Hiller Corp||Implantable drug administrator|
|US3538917 *||Apr 12, 1968||Nov 10, 1970||Robert G Selker||Balloon occlusion clip|
|1||*||In Vivo Metric Systems Bulletin, March 1968, 2 shts. of Bulletin.|
|2||*||Khouri et al., Jour. of Applied Physiology. Vol. 23 No. 3, Sept. 1967, pp. 395 397.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3828116 *||Sep 28, 1973||Aug 6, 1974||Anaconda Co||Inflatable corona ring and cable termination method employing same|
|US3875928 *||Aug 16, 1973||Apr 8, 1975||Angelchik Jean P||Method for maintaining the reduction of a sliding esophageal hiatal hernia|
|US4063555 *||Jan 22, 1976||Dec 20, 1977||Aktiebolaget Stille-Werner||Cannula assembly|
|US4209010 *||Jul 26, 1978||Jun 24, 1980||The Kendall Company||Artificial sphincter|
|US4210131 *||Jul 26, 1978||Jul 1, 1980||The Kendall Company||Artificial sphincter with collection bag|
|US4210132 *||Jul 26, 1978||Jul 1, 1980||The Kendall Company||Artificial sphincter|
|US4253201 *||May 24, 1979||Mar 3, 1981||Ross David A||Prosthesis with self-sealing valve|
|US4256094 *||Jun 18, 1979||Mar 17, 1981||Kapp John P||Arterial pressure control system|
|US4291701 *||Jul 11, 1978||Sep 29, 1981||Bell & Howell Company||Pressure transducing and methods and apparatus for filling a cavity|
|US4365635 *||Mar 3, 1981||Dec 28, 1982||Bell & Howell Company||Pressure transducing methods and apparatus|
|US4419092 *||Nov 6, 1981||Dec 6, 1983||Motion Control, Inc.||Iontophoretic electrode structure|
|US4419985 *||Mar 24, 1982||Dec 13, 1983||Medical Engineering Corporation||Apparatus for reversibly closing a body passage|
|US4517967 *||Apr 18, 1983||May 21, 1985||Dacomed Corporation||Penile prosthesis|
|US4522198 *||Apr 18, 1983||Jun 11, 1985||Dacomed Corporation||Penile prosthesis|
|US4531519 *||Jun 18, 1984||Jul 30, 1985||Dunn David C||Vascular clamp|
|US4546499 *||Dec 13, 1982||Oct 15, 1985||Possis Medical, Inc.||Method of supplying blood to blood receiving vessels|
|US4549531 *||Aug 3, 1984||Oct 29, 1985||Medical Engineering Corporation||Artificial sphincter with inflatable cuff|
|US4556050 *||May 2, 1984||Dec 3, 1985||Hodgson Darel E||Artificial sphincter including a shape memory member|
|US4562597 *||Apr 29, 1983||Jan 7, 1986||Possis Medical, Inc.||Method of supplying blood to blood receiving vessels|
|US4584990 *||Oct 2, 1984||Apr 29, 1986||Habley Medical Technology Corporation||Prosthetic sphincter having a diametric occlusion geometry|
|US4586501 *||Oct 19, 1983||May 6, 1986||Michel Claracq||Device for partly occluding a vessel in particular the inferior vena cava and inherent component of this device|
|US4592339 *||Jun 12, 1985||Jun 3, 1986||Mentor Corporation||Gastric banding device|
|US4601718 *||Jul 13, 1984||Jul 22, 1986||Possis Medical, Inc.||Vascular graft and blood supply method|
|US4632114 *||Mar 22, 1985||Dec 30, 1986||C. R. Bard, Inc.||Urethral sphincter cuff|
|US4708140 *||May 8, 1986||Nov 24, 1987||Baron Howard C||Atraumatic vascular balloon clamp|
|US4800879 *||Jul 9, 1987||Jan 31, 1989||Vladimir Golyakhovsky||Disposable vascular occluder|
|US4828544 *||Sep 5, 1985||May 9, 1989||Quotidian No. 100 Pty Limited||Control of blood flow|
|US4881531 *||Apr 27, 1989||Nov 21, 1989||Dacomed Corporation||Position stable segmented column penile prosthesis|
|US4950276 *||Oct 10, 1989||Aug 21, 1990||Vince Dennis J||Prosthesis for banding of an artery capable of dilation by a balloon dilator|
|US5330498 *||Dec 17, 1991||Jul 19, 1994||Hill John D||Blood vessel occlusion trocar|
|US5499996 *||Mar 14, 1994||Mar 19, 1996||Hill; John D.||Blood vessel occlusion trocar|
|US5522838 *||Jun 7, 1995||Jun 4, 1996||Hill; John D.||Blood vessel occlusion trocar|
|US5556412 *||Jun 7, 1995||Sep 17, 1996||Hill; John D.||Blood vessel occlusion trocar|
|US5707336 *||Jan 9, 1995||Jan 13, 1998||Cardassist Incorporated||Ventricular assist device|
|US5797879 *||Aug 26, 1996||Aug 25, 1998||Decampli; William M.||Apparatus and methods for providing selectively adjustable blood flow through a vascular graft|
|US5910124 *||Jan 8, 1998||Jun 8, 1999||Cardiassist Incorporated||Ventricular assist device and method|
|US5935103 *||Jul 18, 1997||Aug 10, 1999||Heartport, Inc.||Blood vessel occlusion device|
|US5941894 *||Jul 18, 1997||Aug 24, 1999||Heartport, Inc.||Blood vessel occlusion device|
|US5997505 *||Jul 18, 1997||Dec 7, 1999||Heartport, Inc.||Method of cannulating an ascending aorta using a blood vessel occlusion device|
|US6053891 *||May 13, 1998||Apr 25, 2000||Decampli; William M.||Apparatus and methods for providing selectively adjustable blood flow through a vascular graft|
|US6120534 *||Oct 29, 1997||Sep 19, 2000||Ruiz; Carlos E.||Endoluminal prosthesis having adjustable constriction|
|US6224619||Sep 17, 1996||May 1, 2001||Heartport, Inc.||Blood vessel occlusion trocar having size and shape varying insertion body|
|US6506206 *||Jan 13, 2000||Jan 14, 2003||Depuy Orthopaedics, Inc.||Gel tourniquet cuff|
|US6511490 *||Jun 22, 2001||Jan 28, 2003||Antoine Jean Henri Robert||Gastric banding device and method|
|US6749598||Jan 11, 1999||Jun 15, 2004||Flowmedica, Inc.||Apparatus and methods for treating congestive heart disease|
|US6986751||Oct 31, 2003||Jan 17, 2006||Cabg Medical, Inc.||Grafted network incorporating a multiple channel fluid flow connector|
|US6991615||Aug 2, 2004||Jan 31, 2006||Cabg Medical, Inc.||Grafted network incorporating a multiple channel fluid flow connector|
|US6994700||Mar 18, 2005||Feb 7, 2006||Flowmedica, Inc.||Apparatus and method for inserting an intra-aorta catheter through a delivery sheath|
|US7011643||Aug 5, 2003||Mar 14, 2006||Cabg Medical, Inc.||Grafted network incorporating a multiple channel fluid flow connector|
|US7025741||Jun 6, 2003||Apr 11, 2006||Creativasc Medical Llc||Arteriovenous access valve system and process|
|US7063679||Sep 20, 2002||Jun 20, 2006||Flowmedica, Inc.||Intra-aortic renal delivery catheter|
|US7104981||Oct 25, 2005||Sep 12, 2006||Flowmedica, Inc.||Apparatus and method for inserting an intra-aorta catheter through a delivery sheath|
|US7122019||Nov 28, 2000||Oct 17, 2006||Flowmedica Inc.||Intra-aortic renal drug delivery catheter|
|US7241273||Aug 6, 2003||Jul 10, 2007||Flowmedica, Inc.||Intra-aortic renal delivery catheter|
|US7311717 *||Jun 2, 2004||Dec 25, 2007||Ami Agency For Medical Innovations Gmbh||Device for generating an artificial constriction in the gastrointestinal tract|
|US7329236||Sep 7, 2005||Feb 12, 2008||Flowmedica, Inc.||Intra-aortic renal drug delivery catheter|
|US7335192||May 13, 2003||Feb 26, 2008||Flowmedica, Inc.||Apparatus and methods for treating congestive heart disease|
|US7341570||Jul 3, 2003||Mar 11, 2008||Flowmedica, Inc.||Apparatus and methods for treating congestive heart disease|
|US7344548 *||Mar 3, 2005||Mar 18, 2008||Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College||Micro-pneumatic snare|
|US7364566||Mar 18, 2005||Apr 29, 2008||Flowmedica, Inc.||Method and apparatus for intra-aortic substance delivery to a branch vessel|
|US7481803||Apr 23, 2003||Jan 27, 2009||Flowmedica, Inc.||Intra-aortic renal drug delivery catheter|
|US7563247||Aug 6, 2003||Jul 21, 2009||Angiodynamics, Inc.||Intra-aortic renal delivery catheter|
|US7585836||May 13, 2005||Sep 8, 2009||Goodson Iv Harry Burt||Bi-lateral local renal delivery for treating congestive heart failure and for BNP therapy|
|US7766961||Dec 5, 2005||Aug 3, 2010||Angio Dynamics, Inc.||Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens|
|US7771401||Jun 5, 2007||Aug 10, 2010||Angiodynamics, Inc.||Selective renal cannulation and infusion systems and methods|
|US7780628||May 1, 2000||Aug 24, 2010||Angiodynamics, Inc.||Apparatus and methods for treating congestive heart disease|
|US7828814||Apr 4, 2007||Nov 9, 2010||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US7914503||Mar 16, 2005||Mar 29, 2011||Angio Dynamics||Method and apparatus for selective material delivery via an intra-renal catheter|
|US7993325||Sep 29, 2005||Aug 9, 2011||Angio Dynamics, Inc.||Renal infusion systems and methods|
|US7998220 *||Feb 4, 2004||Aug 16, 2011||Murphy Timothy P||Methods for treating obesity|
|US8012121||Jun 26, 2007||Sep 6, 2011||Angiodynamics, Inc.||Method and apparatus for selective material delivery via an intra-renal catheter|
|US8088171||Nov 22, 2006||Jan 3, 2012||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US8114044||Feb 27, 2006||Feb 14, 2012||Creativasc Medical, Llc||Arteriovenous access valve system and process|
|US8226592 *||Dec 15, 2004||Jul 24, 2012||Rox Medical, Inc.||Method of treating COPD with artificial arterio-venous fistula and flow mediating systems|
|US8273095||Jul 13, 2009||Sep 25, 2012||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US8357176||Jul 18, 2007||Jan 22, 2013||Fibro Control, Inc.||Fibroid treatment apparatus and method|
|US8403953||Jul 27, 2009||Mar 26, 2013||Fibro Control, Inc.||Balloon with rigid tube for occluding the uterine artery|
|US8518011||Aug 28, 2009||Aug 27, 2013||Angiodynamics, Inc.||Sheath for use in peripheral interventions|
|US8523800||Sep 22, 2010||Sep 3, 2013||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US8585678||Mar 7, 2008||Nov 19, 2013||Angiodynamics, Inc.||Method and apparatus for intra-aortic substance delivery to a branch vessel|
|US8734472||Aug 29, 2012||May 27, 2014||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US8764698||Dec 21, 2012||Jul 1, 2014||Creativasc Medical, Llc||Arteriovenous access valve system and process|
|US8932341||Dec 21, 2010||Jan 13, 2015||Rox Medical, Inc.||Method for establishing an artificial arterio-venous fistula|
|US8951226||Aug 20, 2009||Feb 10, 2015||Chest Innovations, Inc.||Mediastinoscopy access, sampling, and visualization kit featuring toroidal balloons and exotracheal method of using|
|US9011362 *||Jun 21, 2012||Apr 21, 2015||Rox Medical, Inc.||Method of treating COPD with artificial arterio-venous fistula and flow mediating systems|
|US9023097||Aug 22, 2013||May 5, 2015||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US9125655 *||Jul 18, 2011||Sep 8, 2015||California Institute Of Technology||Correction and optimization of wave reflection in blood vessels|
|US9468441||Oct 31, 2011||Oct 18, 2016||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US9510832||Jan 9, 2015||Dec 6, 2016||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US20030208231 *||Nov 8, 2001||Nov 6, 2003||Williamson Warren P.||Surgical clamp devices and methods especially useful in cardiac surgery|
|US20040059179 *||Aug 6, 2003||Mar 25, 2004||Mark Maguire||Intra-aortic renal delivery catheter|
|US20040059276 *||Sep 20, 2002||Mar 25, 2004||Flomedica, Inc.||Intra-aortic renal delivery catheter|
|US20040064089 *||Apr 23, 2003||Apr 1, 2004||Kesten Randy J.||Intra-aortic renal drug delivery catheter|
|US20040064091 *||May 13, 2003||Apr 1, 2004||Gad Keren||Apparatus and methods for treating congestive heart disease|
|US20040097900 *||Jul 3, 2003||May 20, 2004||Gad Keren||Apparatus and methods for treating congestive heart disease|
|US20040138684 *||Dec 18, 2003||Jul 15, 2004||The University Of Miami||Venous anti-reflux implant|
|US20040228411 *||Sep 16, 2003||Nov 18, 2004||Sony Corporation||Method and system for decoder clock control in presence of jitter|
|US20040249334 *||Jun 6, 2003||Dec 9, 2004||Cull David L.||Arteriovenous access valve system and process|
|US20040267377 *||Jun 2, 2004||Dec 30, 2004||Walter Egle||Device for generating an artificial constriction in the gastrointestinal tract|
|US20050033218 *||Oct 31, 2003||Feb 10, 2005||Villafana Manuel A.||Grafted network incorporating a multiple channel fluid flow connector|
|US20050033219 *||Aug 2, 2004||Feb 10, 2005||Villafana Manuel A.||Grafted network incorporating a multiple channel fluid flow connector|
|US20050171556 *||Feb 4, 2004||Aug 4, 2005||Murphy Timothy P.||Systems and methods for treating obesity|
|US20050197624 *||Mar 4, 2005||Sep 8, 2005||Flowmedica, Inc.||Sheath for use in peripheral interventions|
|US20050245882 *||Mar 18, 2005||Nov 3, 2005||Flowmedica, Inc.||Method and apparatus for intra-aortic substance delivery to a branch vessel|
|US20050245892 *||Mar 18, 2005||Nov 3, 2005||Flowmedica, Inc.||Apparatus and method for inserting an intra-aorta catheter through a delivery sheath|
|US20050267010 *||May 13, 2005||Dec 1, 2005||Flowmedica, Inc.||Bi-lateral local renal delivery for treating congestive heart failure and for BNP therapy|
|US20060036218 *||Mar 16, 2005||Feb 16, 2006||Flowmedica, Inc.||Method and apparatus for selective material delivery via an intra-renal catheter|
|US20060047337 *||Aug 27, 2004||Mar 2, 2006||Brenneman Rodney A||Device and method for establishing an artificial arterio-venous fistula|
|US20060069323 *||Sep 22, 2005||Mar 30, 2006||Flowmedica, Inc.||Systems and methods for bi-lateral guidewire cannulation of branched body lumens|
|US20060129083 *||Dec 15, 2004||Jun 15, 2006||Rox Medical, Inc.||Method of treating COPD with artificial arterio-venous fistula and flow mediating systems|
|US20060149350 *||Dec 5, 2005||Jul 6, 2006||Flowmedica, Inc.||Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens|
|US20060167437 *||Dec 16, 2005||Jul 27, 2006||Flowmedica, Inc.||Method and apparatus for intra aortic substance delivery to a branch vessel|
|US20060189960 *||Sep 7, 2005||Aug 24, 2006||Flowmedica, Inc.||Intra-aortic renal drug delivery catheter|
|US20060200193 *||Mar 3, 2005||Sep 7, 2006||Eiji Toyota||Micro-pneumatic snare|
|US20060206123 *||Feb 17, 2006||Sep 14, 2006||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US20060229548 *||Feb 27, 2006||Oct 12, 2006||Creativasc Medical Lld||Arteriovenous access valve system and process|
|US20070100314 *||Nov 21, 2006||May 3, 2007||Flowmedica, Inc.||Apparatus and methods for treating congestive heart disease|
|US20070167913 *||Oct 11, 2006||Jul 19, 2007||Flowmedica, Inc.||Vascular sheath with variable lumen construction|
|US20070173867 *||Nov 22, 2006||Jul 26, 2007||Brenneman Rodney A||Device and method for establishing an artificial arterio-venous fistula|
|US20070213686 *||Feb 3, 2006||Sep 13, 2007||Flowmedica, Inc.||System and method for prevention of radiocontrast induced nephropathy|
|US20070249985 *||Apr 4, 2007||Oct 25, 2007||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US20070249997 *||Jun 26, 2007||Oct 25, 2007||Flowmedica, Inc.||Method and apparatus for selective material delivery via an intra-renal catheter|
|US20070287967 *||Jun 5, 2007||Dec 13, 2007||Flowmedica, Inc.||Selective renal cannulation and infusion systems and methods|
|US20080051879 *||Aug 23, 2007||Feb 28, 2008||Cook Incorporated||Methods of treating venous valve related conditions with a flow-modifying implantable medical device|
|US20080097497 *||Oct 10, 2007||Apr 24, 2008||Assad Samy R||Pulmonary artery banding device|
|US20080221551 *||Mar 7, 2008||Sep 11, 2008||Flowmedica, Inc.||Acute kidney injury treatment systems and methods|
|US20080300528 *||May 29, 2007||Dec 4, 2008||Creativasc Medical Llc||Arteriovenous access valve system and process|
|US20090030498 *||Sep 2, 2008||Jan 29, 2009||Creativasc Medical||Arteriovenous Access Valve System and Process|
|US20090093758 *||Oct 31, 2006||Apr 9, 2009||Yossi Gross||Fibroid treatment apparatus and method|
|US20090105799 *||Oct 22, 2008||Apr 23, 2009||Flowmedica, Inc.||Renal assessment systems and methods|
|US20090275876 *||Jul 13, 2009||Nov 5, 2009||Rox Medical, Inc.||Device and method for establishing an artificial arterio-venous fistula|
|US20090318857 *||Aug 28, 2009||Dec 24, 2009||Flowmedica, Inc.||Sheath for use in peripheral interventions|
|US20090318950 *||Jul 18, 2007||Dec 24, 2009||Yossi Gross||Fibroid treatment apparatus and method|
|US20100049162 *||Aug 20, 2009||Feb 25, 2010||Chest Innovations, Inc.||Mediastinoscopy access, sampling, and visualization kit featuring toroidal balloons and exotracheal method of using|
|US20100130835 *||Sep 30, 2009||May 27, 2010||Rox Medical, Inc.||Methods for screening and treating patients with compromised cardiopulmonary function|
|US20110022073 *||Jul 27, 2009||Jan 27, 2011||Fibro Control, Inc.||Balloon with rigid tube for occluding the uterine artery|
|US20110226253 *||Mar 16, 2010||Sep 22, 2011||Exclusive Computer Innovations, Llc||Cough shield|
|US20120053672 *||Jul 18, 2011||Mar 1, 2012||Morteza Gharib||Correction and Optimization of Wave Reflection In Blood Vessels|
|US20120316487 *||Jun 21, 2012||Dec 13, 2012||Rox Medical, Inc.||Method of treating copd with artificial arterio-venous fistula and flow mediating systems|
|US20140213988 *||Aug 30, 2012||Jul 31, 2014||Perouse Medical||Kit for maneuvering an element present in the body of a patient, comprising an implantable chamber|
|US20140236211 *||Feb 18, 2013||Aug 21, 2014||King Abdullah International Medical Research Center||Minimally invasive pulmonary artery band|
|CN104379071A *||Mar 26, 2013||Feb 25, 2015||医疗创新开发公司||Adjustable vascular ring, means for treating SFS syndrome and implantable kit including said ring, mold and method for obtaining such ring|
|DE10261937A1 *||Dec 20, 2002||Oct 14, 2004||Scholz, Martin, Dr. med. PD||Temporary clip for sealing supply blood-vessels during a surgical operation moves from an open to a closed position by means of an adjusting device|
|DE10261937B4 *||Dec 20, 2002||Aug 16, 2007||Scholz, Martin, Dr. med. PD||Temporärclip zum Verschließen zuführender Blutgefäße während eines chirurgischen Eingriffs|
|EP0021804A1 *||Jun 20, 1980||Jan 7, 1981||Drg (Uk) Limited||Vascular clamp|
|EP0107231A1 *||Oct 3, 1983||May 2, 1984||Michel Claracq||Partial occlusive device for blood vessels, in particular the vena cava|
|EP0200286A2 *||Jan 20, 1986||Nov 5, 1986||Quotidian No. 100 Pty. Limited||Control of blood flow|
|EP0200286A3 *||Jan 20, 1986||Jan 14, 1987||Quotidian No. 100 Pty. Limited||Control of blood flow|
|WO1984002266A1 *||Dec 8, 1983||Jun 21, 1984||Possis Medical Inc||Vascular graft and blood supply method|
|WO1988000455A1 *||Jul 17, 1987||Jan 28, 1988||Quotidian No. 100 Pty. Limited||Control of blood flow to an organ|
|WO2001083016A3 *||Apr 27, 2001||Jul 18, 2002||Libra Medical Systems Inc||Apparatus and methods for treating congestive heart disease|
|WO2002011623A1 *||Aug 9, 2001||Feb 14, 2002||Stille Surgical Ab||Surgical operation instrument for temporarily squeezing a blood vessel mechanically on each side of a bleeding injury to a vessel|
|WO2006066210A3 *||Dec 15, 2005||Feb 15, 2007||Rox Medical Inc||Method of treating copd with artificial arterio-venous fistula and flow mediating systems|
|WO2007059594A1 *||Apr 4, 2006||May 31, 2007||Samy Renato Assad||Pulmonary artery banding device|
|WO2008012802A3 *||Jul 18, 2007||May 7, 2009||Yossi Gross||Fibroid treatment apparatus and method|
|WO2013144148A3 *||Mar 26, 2013||Dec 19, 2013||Medical Innovation Developpement||Adjustable vascular ring, means for treating sfs syndrome and implantable kit including said ring, mold and method for obtaining such ring|
|WO2014158612A1 *||Feb 26, 2014||Oct 2, 2014||Mortarless Technologies Llc||Arterial constrictor for weight loss treatment|
|U.S. Classification||606/158, 128/DIG.250, 606/202|
|International Classification||A61B17/00, A61B17/28, A61M39/02, A61B17/122|
|Cooperative Classification||A61B2017/00557, A61B17/135, Y10S128/25, A61M39/0208, A61B17/122|
|European Classification||A61M39/02B, A61B17/122|