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Publication numberUS3753657 A
Publication typeGrant
Publication dateAug 21, 1973
Filing dateJun 11, 1971
Priority dateJun 11, 1971
Also published asCA958563A1
Publication numberUS 3753657 A, US 3753657A, US-A-3753657, US3753657 A, US3753657A
InventorsDowning H, Lawson C, Sturgis B
Original AssigneeMicromedic Systems Inc
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Automatic test tube transporter and sample dispenser having solid state controls
US 3753657 A
Abstract
An automatically controlled test tube transporter apparatus which advances a test tube rack containing two rows of receptacles for test tubes under a vertically movable aspirating and dispensing tip or nozzle which is adapted to move down into adjacent tubes and aspirate or discharge depending on the test to be performed. The tip is operationally in communication with a twin pipette metering and dispensing apparatus which includes a linearly adjustable eccentric mechanism which drives the pipette pistons with a motion of adjustable sinusoidal amplitude. The apparatus includes a solid state control circuit which includes a binary shift register. The pipettes may be adjusted to either work in parallel or alternating strokes. An automatic tip wiping mechanism, controlled by the operation of the tip, is provided to insure precision in the processing. The apparatus is adapted to be set for continuous operation or for individual test tube processing cycle operation. Empty racks can be advanced without engaging the tip and pump apparatus. The pipetting mechanism may be operated separately without the operation of the transporting mechanism. A malfunction and alarm logic circuit gives a warning in case of certain malfunctions and stops the apparatus.
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Description  (OCR text may contain errors)

United States Patent [191 Downing et al.

111 3,753,657 Aug. 21, 1973 1 AUTOMATIC TEST TUBE TRANSPORTER AND SAMPLE DISPENSER HAVING SOLID STATE CONTROLS [75] Inventors: Harvey T. Downing, Huntsville;

Charles V. Lawson, Arab; Byron E. Sturgis, Huntsville, all of Ala.

[73] Assignee: Micromedic Systems, Inc.,

Philadelphia, Pa.

[22] Filed: June 11, 1971 [21] Appl. No.: 152,189

[52] US. Cl 23/253 R, 23/259, 73/425.6, 141/130 [51] Int. Cl. G0ln 21/00 [58] Field of Search 23/230, 253, 292, 23/259; 141/130 [56] References Cited UNITED STATES PATENTS 3,143,393 8/1964 DeSeguin Des Hons 23/259 X 3,197,285 7/1965 Rosen 23/259 X 3,327,535 6/1967 Sequeira 23/259 X 3,413,097 11/1968 Jungner 23/259 X 3,576,605 4/1971 Drake et al. 23/259 3,622,279 11/1971 Moran '23/259 3,687,632 8/1972 Natelson 23/259 UP? g 20 2o i'ilff 2i l8 '1 g I T l'l Primary Examiner-Morris O. Wolk Assistant Examiner--R. E. Serwin Attorney-Gerry J. Elman et al.

[5 7] ABSTRACT An automatically controlled test tube transporter apparatus which advances a test tube rack containing two rows of receptacles for test tubes under a vertically movable aspirating and dispensing tip or nozzle which is adapted to move down into adjacent tubes and aspirate or discharge depending on the test to be performed. The tip is operationally in communication with a twin pipette metering and dispensing apparatus which includes a linearly adjustable eccentric mechanism which drives the pipette pistons with a motion of adjustable sinusoidal amplitude. The apparatus includes a solid state control circuit which includes a binary shift register. The pipettes may be adjusted to either work in parallel or alternating strokes. An automatic tip wiping mechanism, controlled by the operation of the tip, is provided to insure precision in the processing. The apparatus is adapted to be set for continuous operation or for individual test tube processing cycle operation. Empty racks can be advanced without engaging the tip and pump apparatus. The pipetting mechanism may be operated separately without the operation of the transporting mechanism. A malfunction andalarm logic circuit gives a warning in case of certain malfunctions and stops the apparatus.

48 Claims, 36 Drawing Figures Patented Aug. 21, 1973 R 3,753,657

22 Sheets-Sheet 1 INVENTOR HARVEY 7f DOWN/N6 CHARLES LAWSON, BYRON E. STURGIS H 9 LL ATTORNEX} Patented Aug. 21, 1973 22 Sheets-Sheet 2 Patented Aug. 21, 1973 3,753,657

22 Sheets-Sheet 5 FIG Patented Aug; 21, 1973 22 Sheets-Sheet 4.

Patented Aug. 21, 1973 22 Sheets-Sheet 5 Patented Aug. 21, 1973 22 Sheets-Sheet 6 Patented Aug. 21, 1973 22 Sheets-Sheet '7 mmm 0mm llmn wwm Patented Aug. 21, 1973 22 Sheets-Sheet 9 .mmm

Patented Aug. 21, 1973 22 Sheets-Sheet 12 Patented Aug. 21, 1973 22 Sheets-Sheet l5 .954 Jmmh Omh mmh wmw 5% mm bow Patented Aug. 21, 1973 22 Sheets-Sheet 15 mmm Nmm

wk EN Nwh Ow. mi. @vh 9 at Patented Aug. 21, 1973 22 Sheets-Sheet l 9 FIG 29

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US3143393 *Jun 13, 1960Aug 4, 1964Luc Donald De Seguin Des HonsApparatus for automatically performing chemical operations and similar or related operations
US3197285 *May 8, 1961Jul 27, 1965Rosen SidneySampling machine
US3327535 *Aug 24, 1964Jun 27, 1967Sequeira Peter Jam LittlejohnsMultiple pipetting apparatus
US3413097 *May 18, 1965Nov 26, 1968Centrala AutomationslaboratoriAutomatic pipette-system arrangement, the action of which is controlled, for transferring liquid from one test to another
US3576605 *Feb 11, 1969Apr 27, 1971Baird & Tatlock LtdMultiple pipetting apparatus
US3622279 *Jun 14, 1968Nov 23, 1971Hycel IncAutomatic chemical testing apparatus
US3687632 *Dec 4, 1970Aug 29, 1972Rohe Scientific CorpSystem for transferring liquids between containers
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3883305 *Mar 14, 1973May 13, 1975Coulter ElectronicsAutomatic chemical analysis apparatus
US3883306 *Nov 23, 1973May 13, 1975Aga AbAutomatic analyzing arrangement
US3951605 *Aug 8, 1974Apr 20, 1976Rohe Scientific CorporationInstrument for automated immunochemical analysis
US3981041 *Aug 22, 1974Sep 21, 1976The Perkin-Elmer CorporationSponge irrigation system for automatic analysis apparatus
US3999949 *Dec 27, 1974Dec 28, 1976Duni-Bila AbAbsorbers
US4052161 *Jul 10, 1975Oct 4, 1977The Perkin-Elmer CorporationKinetic analyzer
US4131426 *Aug 24, 1977Dec 26, 1978Baxter Travenol Laboratories, Inc.Tip wiper apparatus and method
US4169125 *Apr 14, 1977Sep 25, 1979Baxter Travenol Laboratories, Inc.Automatic nephelometer apparatus
US4199013 *Apr 1, 1977Apr 22, 1980Packard Instrument Company, Inc.Liquid sample aspirating and/or dispensing system
US4399712 *Mar 30, 1981Aug 23, 1983Nichiryo Co., Ltd.Semi-automatic electro-mechanical pipette with controlled tip remover
US4422151 *Jun 1, 1981Dec 20, 1983Gilson Robert ELiquid handling apparatus
US4727032 *Feb 15, 1985Feb 23, 1988Eppendorf Geratebau Netheler & Hinz GmbhProcess for the thermostatic control of a sample fluid to be analyzed, apparatus for performing the process
US4751186 *Feb 15, 1985Jun 14, 1988Eppendorf Geratebau Netheler & Hinz GmbhProcess for performing sample analyses and rack for performing the process
US5271897 *Jul 14, 1992Dec 21, 1993Eastman Kodak CompanyDevice for raising and lowering covers of containers filled with liquid to be analyzed
US5380666 *Apr 26, 1993Jan 10, 1995Eastman Kodak CompanyMethod for scanning and centering containers filled with a liquid
US5585068 *Oct 14, 1994Dec 17, 1996Biochemical Diagnostics, Inc.Column transport disc with compound bores which allow columns to be easily positioned, transported past a plurality of reagent/gas dispense stations and ejected after use
US5795784 *Sep 19, 1996Aug 18, 1998Abbott LaboratoriesMethod of performing a process for determining an item of interest in a sample
US5856194 *Sep 19, 1996Jan 5, 1999Abbott LaboratoriesMethod for determination of item of interest in a sample
US6562298Apr 23, 1999May 13, 2003Abbott LaboratoriesStructure for determination of item of interest in a sample
US6782927 *Dec 3, 2002Aug 31, 2004Ace Hardware CorporationCan filler valve wiper mechanism
US6824010 *Sep 29, 2000Nov 30, 2004Fuji Electric Co., Ltd.Selective actuating apparatus
US7635246Oct 27, 2007Dec 22, 2009Nexus Biosystems, Inc.Device and method for retrieving or replacing a tray within a storage compartment
US7648321Oct 27, 2007Jan 19, 2010Nexus Biosystems, Inc.System and method for partitioning a temperature controlled compartment
US7793842Oct 27, 2007Sep 14, 2010Nexus Biosystems, Inc.Device and method for reading bar codes on an object
US8083994Oct 28, 2007Dec 27, 2011Brooks Automation, Inc.System and method for selectively extracting individual vials from an array of vials within a rack
US8092507 *Dec 14, 2007Jan 10, 2012Novian Health, Inc.Interstitial energy treatment probe holders
US8252232Jan 23, 2007Aug 28, 2012Brooks Automation, Inc.Automated system for storing, retrieving and managing sample
US8518095Dec 14, 2011Aug 27, 2013Novian Health, Inc.Interstitial energy treatment probe holders
US20130045145 *Oct 23, 2012Feb 21, 2013Gen-Probe IncorporatedContamination control for liquid handling
EP1518605A2 *Sep 15, 2004Mar 30, 2005RTS Thurnall PLCCompounds storage vessel handling apparatus
Classifications
U.S. Classification422/65, 141/130, 73/863.32, 73/864.24, 73/864.22, 73/864.16
International ClassificationB01L9/06, G01N35/10, B01L9/00
Cooperative ClassificationB01L9/06, G01N35/1004, G01N35/10
European ClassificationB01L9/06, G01N35/10
Legal Events
DateCodeEventDescription
Dec 11, 1990ASAssignment
Owner name: FIRST CITY, TEXAS-HOUSTON, N.A.
Free format text: SECURITY INTEREST;ASSIGNOR:ICN MICROMEDIC SYSTEMS, INC., A CORP. OF CA;REEL/FRAME:005529/0609
Effective date: 19901130
Dec 11, 1990AS06Security interest
Owner name: FIRST CITY, TEXAS-HOUSTON, N.A.
Owner name: ICN MICROMEDIC SYSTEMS, INC., A CORP. OF CA
Effective date: 19901130
Nov 13, 1989ASAssignment
Owner name: FIRST CITY, , A NATIONAL BANKING ASSOCIATION, TEX
Free format text: SECURITY INTEREST;ASSIGNOR:ICN MICROMEDIC SYSTEMS, INC.;REEL/FRAME:005194/0966
Effective date: 19891108
Dec 13, 1985ASAssignment
Owner name: ICN MICROMEDIC SYSTEMS, INC., 3300 HYLAND AVENUE,
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:MICROMEDIC SYSTEMS, INC., A CORP OF DE.;REEL/FRAME:004488/0488
Effective date: 19851121
Mar 17, 1981ASAssignment
Owner name: ROHM & HAAS COMPANY (MERGED WITH AND INTO)
Free format text: RE-RECORD OF AN INSTRUMENT RECORDED OCT. 6, 1980, REEL 3804, FRAMES 837-840, TO SHOW NEW OWNER OF SAID PATENTS;ASSIGNOR:MICROMEDIC SYSTEMS, INC.;REEL/FRAME:003848/0449
Effective date: 19800903
Owner name: ROHM & HAAS COMPANY (MERGED WITH AND INTO),PENNSYL
Free format text: RE-RECORD OF AN INSTRUMENT RECORDED OCT. 6, 1980, REEL 3804, FRAMES 837-840, TO SHOW NEW OWNER OF SAID PATENTS;ASSIGNOR:MICROMEDIC SYSTEMS, INC.;REEL/FRAME:3848/449
Owner name: ROHM & HAAS COMPANY (MERGED WITH AND INTO), PENNSY