|Publication number||US3760984 A|
|Publication date||Sep 25, 1973|
|Filing date||Sep 29, 1971|
|Priority date||Sep 29, 1971|
|Publication number||US 3760984 A, US 3760984A, US-A-3760984, US3760984 A, US3760984A|
|Original Assignee||Alza Corp|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (1), Non-Patent Citations (1), Referenced by (202), Classifications (13)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent 91 Theeuwes [451 Sept. 25, 1973 OSMOTICALLY POWERED AGENT DISPENSING DEVICE WITH FILLING MEANS Felix Theeuwes, Los Altos, Calif.
 US. Cl. 222/95, 128/260, 222/386.5,
222/389  Int. Cl B65d 35/28  Field of Search 222/94, 95, 190,
ZZZ/386.5, 389, 394; 129/213, 214 R, 218 R, 218 A, 260, 272; l41/3, 30
 References Cited UNITED STATES PATENTS 3,604,417 9/l97l Stolzeaberg 128/260 X OTHER PUBLICATIONS Australian Journal Experimental Biology (1955), 33, pp. 415-420.
Primary ExaminerRobert B. Reeves Assistant Examiner- -Larry Martin Att0meyPaul L. Sabatine et al.
 ABSTRACT A device is disclosed comprised of a wall formed of a material collapsable in response to mechanical force and surrounding a closed compartment for containing an agent, a dispensing passageway communicates with the compartment and the exterior of the device for dispensing agent therefrom, a filling passageway communicates with the exterior of the device and the compartment for filling the device, a layer of an osmotically effective solute is despoited on the collapsable walls outer surface, said solute capable of exhibiting an osmotic pressure gradient against an external fluid and increasing its volume as fluid diffuses by osmosis into the solute, an outer wall surrounding the layer of solute formed of a material having shape retaining properties, permeable to the fluid and substantially impermeable to solute, and wherein the filling passageway houses a material penetrable to a means for filling the compartment which material self closes on removal of the means to maintain the compartment in closed condition for subsequent collapsing thereof in response to mechanical or hydrostatic force generated by osmotic pressure arising in the solute layer, as fluid diffuses therein to increase its volume and generate forces that are exerted between the collapsable wall of the agent containing chamber and the more rigid outer semipermeable wall, which collapsing force in turn dispenses an agent through the dispensing passageway when the compartment is charged with drug and the device is positioned in the environment of use.
5 Claims, 7 Drawing Figures OSMOTICALLY POWERED AGENT DISPENSING DEVICE WITH FILLING MEANS AREA OF THE INVENTION This invention pertains to both a novel and useful device for dispensing a useful agent. More particularly, the invention relates to a dispensing device for the controlled and continuous dispensing of an agent over a prolonged period of time to produce a desired result. Specifically, the invention concerns an osmotic dispenser manufactured with a minimum number of com-' ponents wherein one of the components is a filling port with a means for self-closing the port to maintain the sterility and operability of the device after the device is charged with agent.
BACKGROUND OF THE INVENTION Osmotic dispensing devices for the delivery of active agent are well known to the prior art. These devices are of assorted designs and generally have a plurality of similar structural components. For example, the devices usually have anexternal wall or housing for containing an internal collapsable chamber for containing an agent. The chamber in the device is surrounded by an osmotically effective solute that is capable of exhibiting a pressure gradient against an extem'al fluid and increasing its volume as external fluid diffuses into the solute to generate a force that is exerted against-the chamber causing it to collapse. As the chamber collapses, it ejects agent through a passageway that lead to the exterior of the device.
While these osmotic devices are useful for dispensing agent, they have certain disadvantages that restrict or tend to defeat their use for many applications. For example, the presently available devices are prefilled with a drug which often looses its sterility prior to use of the drug. Also, some drugs have a short shelf life and these drugs tend to deteriorate during storage and diminish the usefulness of the drug. Additionally, the prior art devices lacked a port for filling the chamber, and if they were filled by puncturing with a hollow needle, the device failed to function either because of osmotic pressure leakage at the puncture site or the device hecame contaminated resulting from mixing of solute and agent arising at the site the inner wall was pierced. Thus, it will be appreciated by those skilled in the art that while the prior art devices made a valuable contribution to the art, the above mentioned disadvantages tended to restrict their use to a few environments.
OBJECTS OF THE INVENTION Accordingly, it is an immediate object of this invention to provide a novel dispensing device for the dispensing of agent to produce a beneficial effect, which device overcomes the aforesaid disadvantages associated with the prior art devices. v
Still another object of the invention is to provide a novel osmotic dispensing device for dispensing an agent at a controlled rate for a prolonged period of time.
Yet still another object of this invention is to provide a novel and useful osmotic dispensing device that is simple in construction, designed with a minimum number of parts, easy to use, and in operation is practical and useful for the controlled, continuous, long-term administration of an agent.
Still another object of the invention is to provide an osmotic dispensing device that has a separate port for filling the device which is self closing to maintain the integrity of the device.
Yet still another object of the invention is to provide an osmotic dispensing device that can be filled with agent when needed from a separate source through a self closing port integral in the device.
Still a further object of the invention is to provide an osmotic dispensing device that is empty until charged and then can administer a complete pharmaceutical dosage regimen for a period of time, the use of which requires intervention only for initiation and termination of the regimen.
Yet another immediate object of this invention is to provide a dispensing device that can be filled with drug at the time of use for administering a drug to produce a locally acting or systemically acting drug to produce a physiologic or pharmacologic effect which device can release the drug at a rate that does not vary with time.
Other objects, features, and advantages of the invention will be apparent to those skilled in the art, from the detailed description of this specification, taken in conjunction with the drawings and the accompanying claims.
SUMMARY OF THE INVENTION The invention concerns a device comprised of an outer wall surrounding an inner wall that defines a compartment as a means for containing an agent. A layer of an osmotically effective solute capable of exhibiting an osmotic pressure gradient against an external fluid is housed between th outer and inner'wall. A dispensing passageway leads from the compartment to the exterior of the device for releasing agent from the device. A filling passageway leads from the exterior of the device to the compartment and'it houses a means for closing the passageway. The outer wall of the device isformed of a material having shape retaining properties and it is permeable to an external fluid and substantially impermeable to solute. The inner wall is formed of a material essentially impermeable to external fluid and solute and collapsable when force is exerted thereon. In operation, external fluid permeates at a rate controlled by the wall permeability, wall dimensions, and osmotic pressure gradient into the solute causing it to increase in volume. The increased volume generatesa mechanical or hydrostatic compressing or deflating pressure on the collapsable wall, which pressure, negligible to the equilibrium in osmotic pressure of the fluid, in turn ejects the active agent out of the chamber at an osmotic-permeation controlled rate over a prolonged and continuous period of time.
BRIEF DESCRIPTION OF THE DRAWINGS In the drawings, which are not drawn to scale, but rather are set forth to illustrate various embodiments of the invention, the drawings are as follows:
FIG. 1 is an elevated illustration of an osmotic dispenser of the invention.
FIG. 2 is a cross-sectional view of FIG. 1 through 2-2 illustrating the structure of the device of FIG. 1.
FIG. 3 is a perspective, top view of a dispensing device of the invention illustrating another embodiment of the invention.
FIGS. 4 through 7 represent a graphic illustration of osmotic pumps showing their release rate from the devices over a prolonged period of time.
In the drawings and specification, like parts in related figures are identified by like numbers. The terms appearing earlier in the specification and in the description of the drawings, as well as embodiments thereof, are further described elsewhere in the disclosure.
DETAILED DESCRIPTION OF THE DRAWINGS Turning now to the drawings in detail, which are examples of various delivery devices of the invention, and which examples are not to be construed as limiting, one embodiment of a novel osmotic delivery device is indicated in FIG. 1 by the number 10. Delivery device 10 is comprised of a body portion 11, a discharge passageway 12 and a filling passageway 13 integrally formed with device 10. A means 14 for self closing filling passageway 13 is seen in broken lines in passageway 13.
Device 10 of FIG. 1 is seen in FIG. 2 in open section through 2-2 of FIG. 1. In FIG. 2, device 10 is comprised of a body 11 formed of an inner wall 15 formed of a flexible material collapsable in response to pressure and relatively impervious to fluid as osmotic solute, the wall surrounds and forms a compartment 16 defined by wall 15s inner surface. Compartment 16 is a means for containing an active agent and it is pro- Vided with a means 17 for dispensing the agent to the 1 exterior of device 10. Compartment 16 is further provided with a means 18 for filling compartment 16. Means 18, also referred to as filling port or filling passageway is Provided with a means 14 for self closing passageway 18. Closing means 14 is made from a material that is essentially impermeable and inert to agent form properties across all its dimensions, that is, it is substantially imperforate or substantially homogenous, or wall 20 can be formed of a material that is microporous.
In FIG. 2, positioned between wall 20 and wall 15 is I a layer 21 of an osmotically effective solute that exhibits an osmotic pressure gradient against an external fluid, when the device is positioned in the environment of use. In operation, these solutes osmotically attract fluid through the semi-permeable membrane 20 to pro duce a solution of the solute which increases in volume while simultaneously generating mechanical or hydrostatic force that is exerted against wall 15 to cause it to correspondingly collapse. As wall 15 collapses it ejects active agent out of chamber 16 through dispensing passageway 17 to the exterior of device. 10 at an osmotically membrane controlled rate over a prolonged period of time.
FIG. 3 illustrates another embodiment of the invention. In FIG. 3, device 10 is illustrated comprised of a body 11 having a pair of ports 22 each distant from the other. Ports 22 can be optionally used as filling ports or discharge ports and each houses a material 14 for closing the port after penetrated by a needle. Additionally,
either port can be equipped with a needle for discharging agent from device 10.
DETAILED DESCRIPTION OF THE INVENTION In accordance with the practice of the present invention, it has now been found that the osmotic delivery device of the invention provides many important advantages over previously known osmotically operated delivery devices. One advantage of the device is the ease of construction of the drug delivery device by standard manufacturing techniques into devices of various shapes and forms for delivering agent to recipient or environment. A more important advantage of the claimed delivery device is that it can be manufactured comprised of a minimum number of parts.
Another important advantage for osmotic delivery device 10 is the device and its agent can be separately stored and the device charged with agent at the time of use. This feature prevents or substantially reduces deterioration of the agent since agents susceptible to deterioration can be stored in glass containers and charged into the device at the time of use. Yet another important advantage for the devices of this invention resides in the users option to formulate special agents or compositions of agents that can be charged into the compartment at the time of use and at the environment of use. Another important advantage for the device resides in the device entering the commerical stream uncharged with agent in a simple sterile package. The feature enhances the utility of the device and simultaneously makes it possible to design special devices for special application that can be charged with agent at the environment of use. These features and other advantages are made available to the art by the invention providing the device with a filling port generally positioned distant from the discharge port. The filling port is equipped with a self sealing or self closing stopper or bung that fills the internal space of the filling port and can be repeatedly penetrated and closed following withdrawal by a penetrating instrument. The filling port housing the bung is constructed with the wall in intimate contact with the bung by shrinking the wall to the bung during fabrication of the device. This unique feature of the device also makes it possible to fill the device with agent without developing air pockets in the compartment and without penetrating the devices walls which could lead to a loss of osmotic pressure and leakage. Additionally, another advantage for the novel osmotic pump is that pumps made with along and narrow catheter which could not be filled heretofore can now be filled by entering the chamber through filling port equipped with the bung.
Wall 20 of the device is a material that is semipermeable, for example a material that is permeable to an external fluid such as water and the like while essentially impermeable to a selected product or to other compounds in the device. The material forming the wall can be non-erodible or bioerodible after a predetermined period of time and in each instance it is semipermeable to external fluid but not to solute and is suitable through its shape retaining properties during its useful life for construction of the osmotic powered device. Typical materials for forming the wall include membranes known to the art as osmosis and reverse osmosis membranes such as commercially available unplasticized cellulose acetate, plasticized cellulose acetate, reinforced cellulose acetate, cellulose nitrate with 1 1 percent nitrogen, cellulose diacetate, cellulose triacetate, agar acetate, amylose triacetate, beta glucan acetate, beta glucan triacetate, celluloseacetate, acetaldehyde dimethyl acetate, cellulose acetate ethyl carbamate, cellulose acetate phthalate, cellulose acetate methyl carbamate, cellulose acetate succinate, cellulose acetate dimethaminoacetate, cellulose acetate ethyl carbonate, cellulose acetate chloroacetate, cellulose acetate ethyl oxalate, cellulose acetate methyl sulfonate, cellulose acetate butyl sulfonate, cellulose acetate propionate, cellulose acetate p-toluene sulfonate, triacetate of locust gum bean, cellulose acetate with acetylated hydroxyethyl cellulose, hydroxylated ethylene-vinylacetate, cellulose acetate butyrate having a viscosity of from about seconds to about 50 seconds, cellulose acetate butyrate containing about 17 percent of combined butyryl and about 29.5 percent acetyl permselective, aromatic nitrogen-containing polymeric membranes that exhibit water permeability and essentially no solute passage, osmosis membranes made from polymeric epoxides, osmosis membranes made from copolymers of an alkylene oxide and alkyl glycidyl ether, semi-permeable polyurethanes, semi-permeable polyglycolic or polylactic acid and derivatives thereof, thin film membranes as disclosed by Loeb and Sourirajan in U. S. Pat. No. 3,133,132, the membranes of ionically associated polyelectrolytes, the polymers formed by the coprecipitation of polycation and a polyanion as described in U. S. Pat. Nos. 3,276,586; 3,541,005; 3,541,006; 3,546,142; 3,173,876; derivatives of polystyrene such as poly(sodium styrenesulfonate) and poly(vinylbenzyltrimethylammonium chloride), and the like. Generally, membranes having a fluid permeability of 0.01 to 10 cclcm /hour or day or higher at atmosphere pressure against a saturated product solution or saturated solute solution to a changing concentration at the temperature of use while simultaneously possessing a high degree of impermeability to the product or solute are useful and within the spirit of the invention.
Wall 15, or the inner wall of the device that defines the compartment and is in intimate contact with bung 14 is a heat shrinkable, polymeric material that collapses on the application of force thereto and simultaneously maintains the self sealing bung in the filling port. The polymeric membrane is selected from the class of heat shrinkable polymeric films in the form of tubes, spheres, ellipsoids, envelopes, films, laminates, and other geometric shapes and fabricated structures is in one embodiment a material that has been prepared by inducing strong molecular orientation by uni-axially or bi-axially stretching of the film, which operation, preferably, can be preceded by the introduction of inter-molecular primary valence cross-linkage by chemical or radiation processes. The degree of cross-linking, when employed, should be sufficient to impart to the film a thermoset character, which can be'conveniently defined as the ability to exhibit a minimum tensile strength of about 50 lbs./in. at a temperature of 300F. By heat shrinkable" is meant in'this embodiment that the film can contract by at least 10 percent and typically from about 25 percent .tO 75 percent of its stretched dimension in one or more directions upon heating. The material is expanded or stretched mechanically, hydraulically, or pneumatically, either uniaxially or bi-axially, at room temperature or elevated temperatures, and then is set or fixed, or frozen, into this expanded, high energy state. Procedures for accomplishing this are well known in the polymer fabrication art. For example, in the manufacture of bi-axially oriented, heat" shrinkable flim, the film is prepared by extrusion through a shaping die with a long, narrow horizontal slit of such width as to give the desired film thickness. As the hot ribbon of polymeric material issues from the die, it is gripped along its two edges by tenter hooks which tend to stretch the film along its width and to stretch it in a forward direction at the same time. This operation imparts bi-axial orientation and yields a film with equal shrinkage along both axes. Typically, such a film will have a potential shrinkage of 50 percent in both directions. Not only is the rate of stretching important in achieving this result, but the rate of cooling and the temperature profile during the stretching are important. As described here, this operation is done in-line with extrusion, but it can also be done on preformed film by heating and stretching the film.
In the manufacture of one type of heat shrinkable tubing for use in the present invention, the polymer is first prepared in tubular shape, preferably by extrusion through a die of the desired cross-sectional configuration. The tubing can then be subjected to ionizing radiation consisting of a stream of high energy electrons as delivered by a van de Graaff generator or other electron accelerating equipment. Or the tubing can be treated with gamma rays as emanating from cobalt-60. The dosage delivered can vary, depending upon the polymer system, from 0.5 to megarads to achieve the desired degree of intermolecular cross-linkage. The tubing is then subjected to uni-axial molecular orientation by drawing it, optimally in a warm or heated condition, over an appropriately shaped mandrel, which increases the cross-sectional area by a factor of 2 to 16. The polymer, having been selected from classes which tned to have high intermolecular attraction, will tend to remain in the high energy, stretched stateuntil heated above a temperature at which these intermolecular attractions are melted or released. The memory or tendency to recover back to the unstretched state is encouraged by the cross-linkage which was introduced by the earlier radiation treatment.
- Polymeric membranes preferably are cross-linked prior to stretching and using to form the inner wall. The chemical cross-linking of these polymers can be achieved by incorporation of various cross-linking agents such as peroxides, sulfur, metallic oxides, selenium, tellerium, diamines, diisocyanates, alkyl phenol disulfides, p-quinone dioxime, tetra-chloro-pbenzoquinone, tetra alkyl thiuram disulfides, 4,4- dithiomorpholine, sulfur dichloride, and the like, into the polymer followed by a period of heating. Alternatively, cross-linking or vulcanization can be achieved by use of high energy electron-beam radiation such as is provided by a van de Graaff generator or other types of electron accelerators, or by gamma ray emitters, or
by X-ray generators.
In another embodiment pre-oriented shrinkable materials suitable for forming the chamber and housing the self sealing bung by engaging the bung when the film is exposed to heat comprise oriented film of vinyl chloride polymer which has a Youngs modulus of elasticity in both directions of at least 200,000 p.s.i. l4,000 kglcm at 23C, a shrinkage of at most 35 per cent at p.s.i. (l0.5 kglcm at any temperature. The films preferably have shrink tensions not exceeding 100 p.s.i. (7 kglcm at any temperature. The most preferred film is a rigid (i.e. unplasticized) polyvinyl chloride filmwhich is 0.01 to 0.95 mm thick and has been bi-axially oriented so that it has a shrinkage in both directions of at most about 20 percent, especially 15 to 20 percent, e.g. about 20 percent. Films having low degrees of orientation or shrink in one direction only, such as are produced directly by some extrusion methods, can be used in accordance with the invention, but require the use of rather high film temperatures, near the melting point of the polymer, in order sufficiently to shrink the film. Accordingly it is preferred to use films which have been bi-axially oriented so that they have percent shrinkages at 100C in both directions of to 35 percent, especially to 25 percent, particularly 15 to percent, and have shrink tensions not exceeding 150 p.s.i. (10.5 kglcm and preferably not exceeding 100 psi. (7.0 kglcm at any temperature; such films are believed to be novel. They can be very satisfactorily used in shrink packaging procedures in which the film only has to reach a maximum temperature of 120C and for regular objects 100C or even less.
The vinyl chloride polymer shrinkable materials used herein include homopolymers and copolymers such as vinyl chloride and vinyl acetate, styrene, acrylonitrite, dialkyl fu'marate or maleate, or alkyl acrylate or methacrylate, vinyl acetate and vinylidene chloride, blends of polyvinyl chloride with chlorinated polyethylene or terpolymer, and the like. Other heat shrinkable materials include vinylidene chloride, copolymers of vinylidene chloride of 20 to 80 percent vinylidene chloride, copolymers of vinylidene chloride and vinyl chloride and the like. Heat shrinkable materials are set forth in US. Pat. Nos. 3,022,543; 3,419,421; 3,459,582; 3,614,852; 3,627,116; and the like.
Various osmotically effective solutes including organic and inorganic compounds are advantageously used for coating on the exterior surface of the inner wall to act as a means for generating osmotic pressure. Suitable solutes exhibit an osmotic pressure gradient against an external fluid across the semi-permeable membrane which membrane is substantially impermeable to the passage of the osmotically effective solute to prevent loss thereof through the membrane. Various osmotically effective solutes include compounds such as magnesium sulfate, magnesium chloride, sodium chloride, lithium chloride, potassium sulfate, sodium carbonate, sodium sulfite, lithium sulfate, calcium bicarbonate, sodium sulfate, calcium sulfate, potassium acid phosphate, calcium lactate, magnesium succinate, tartaric acid, soluble carbohydrates such as raffinose, glucose, mixtures thereof and the like.
Additionally, the solute can be used in a mixed form by mixing the compound with a binder. The'solute in powdered, granular, piece and the like form, is homogenously or heterogenously dispersed in the binder which binder is soluble or insoluble but will release the solute on contact with wall material. Typical binders include polyethylene glycol, gelatin, agar, carboxycellulose, ethylmethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, soluble starch derivatives and the like. Typical binders that can comprise about 1 to 50 percent of the composition include cellulose acetate, polyurethane, epoxides, and other binders that permit the free movement of fluid into the solute of the layered structure to permit the solute to increase in volume and generate osmotic pressure.
The stopper or bung, as confined in the filling passageway, is comprised of naturally occurring or synthetic material that possesses self closing or self sealing properties following the withdrawal therefrom of a piercing instrument. These materials are generally known to the art as elastomers, and they include the commercially available carboxylated butadiene acrylonitrile copolymers, butadiene vinylpyridine copolymers, polychloroprene, isoprene, copolymerized with piperylene, polyisoprene, poly(butadiene-co-styrene), poly(butadiene-co-acrylonitrile), natural rubber, poly- (isobutylene-co-isoprene), silicones, fluroelastomers, butyl rubber, halogenated butyl rubber, poly(butadiene-styrene-vinylpyridine) acrylic rubbers, butadiene:acrylonitrite /20, 73/27, 68/32, 61/39, free radical cross-linked silicone elastomers, and the like.
The phrase active agent and the term agents" as used throughout the specification and the accompanying claims comprises any compound, or mixture of compounds, composition of matter or mixture thereof that can be dispensed from the device to produce a predetermined beneficial and useful result. The active agents include pesticides, germicides, biocides, algicides, rodenticides, fungicides, insecticides, antioxidants, plant growth promoters, plant growth inhibitors, preservating agents, surfactants, disinfectants, sterilization agents, catalysts, chemical reactants, fermentation agents, cosmetics, foods, nutrients, food supplements, drugs, vitamins, sex sterilants, fertility inhibitors, fertility promotors, air purifiers, microorganism attenuators, and other like agents that benefit the environment, surroundings, and habitat including animals, mammals, man, valuable farm animals, household animals, sport animals, and the like.
ln a presently preferred embodiment the active agent is a drug that will produce a local or systemic physiologic or pharmacologic response when administered to animals, including humans, avians, and the like. Suitable drugs that are dispensed in conventional, standard dosage amounts as known to the art comprise desensitizing agents such as ragweed pollen antigens, hay fever pollen antigens, dust antigen and milk antigen; vaccines such as small pox, yellow fever, distemper, hog cholera, fowl pox, antivenom, scarlet fever, diphtheria toxoid, tetanus toxoid, pigeon pox, whooping cough, influen' zae, rabies, mumps, measles, poliomyelitis, Newcastle disease, etc; anti-infectives, such as antibiotics, including penicillin, tetracycline, chlortetracycline, bacitracin, nystatin, streptomycin, neomycin, polymyxin, gramicidin, oxytetracycline, chloramphenicol, and erythromycin; sulfonamides, including sulfacetamide, sulfamethizole, sulfamethazine, sulfadiazine, sulfamerazine, and sulfisoxazole; anti-virals including idoxuridine; and other anti-infectivesincluding nitrofurazone and sodium propionate; anti-allergenics such as antazoline, methapyrilene, chlorpheniramine, pyrilamine and prophenpyridamine; anti-inflammatories such as hydrocortisone, cortisone, hydrocortisone acetate, dexamethasone, dexamethasone 2 1 phosphate,fluocinolone, triamcinolone, medrysone,
prednisolone, prednisolone 2 1 -phosphate, and prednisolone acetate; decongestants such as phenylephrine, naphazoline, and tetrahydrozoline; miotics and anticholinesterases such as pilocarpine, eserine salicylate, carbachol, di-isopropyl fluorophosphate, phospholine iodide, and demecarium bromide; mydriatics such as atropine sulfate, cyclopentolate, homatropine, scopolamine, tropicamide, eucatropine, and hydroxyamphetamine; sympathomimetics such as epinephrine; sedatimes and hypnotics such as pentobarbital sodium, phenobarbital, secobarbital sodium, codeine, (a-bromo-isovaleryl) urea, carbromal; psychic energizers such as 3-( 2-aminopropyl) indole acetate and 3-( 2- aminobutyl) indole acetate; tranquilizers such as reserpine, chlorpromazine, and thiopropazate; androgenic steroids such as methyltestosterone and fluoxymesterone; estrogens such as estrone, 17 B-estradiol, ethinyl estradiol, and diethyl stilbesterol; progestational agents such as progesterone, megestrol, melengestrol, chlormadinone, ethisterone, norethynodrel, l9-norprogesterone, norethindrone, medroxyprogesterone and 17 a-hydroxyprogesterone; humoral agents such as the prostaglandins, for example POE PGE and PFD antipyretics such as aspirin, sodium salicylate, and salicylamide; anti-spasmodics such as atropine, methantheline, papaverine, and methscopolamine bromide; anti-malarials such as the 4-aminoquinolines, 8- aminoquinolines, chloroquine, and pyrimethamine; antihistamines such as diphenhydramine, dimehydrinate, tripelennamine, perphenazine, and carphenazine; cardioactive agents such as hydrochlorothiazide, flumethiazide, chlorothiazide, and trolnitrate; nutritional agents such as vitamins, essential amino acids and essential fats; anti-Parkinsonism agents such as L-dopa, (L-3,4-dihydroxyphenylalanine); investigative antihypotensive agents such as dopamine, 4-(2- aminoethyl) pyrocatechol. Other agents having the same or different physiological activity as those recited above can be employed in osmotic dispensers within the scope of the present invention. Suitable mixtures of drugs can, of course, be explained with equal facility as with single component systems.
The agent can be in various forms, such as unchanged molecules, components of molecular complexes, or non-irritating pharmacologically acceptable salts such as hydrochloride, hydrobromide, sulphate, phosphate, nitrate, borate, acetate, maleate, tartrate, salicylate, and the like. For acidic drugs, salts of metals, amines, or organic cations, for example, quaternary ammonium can be employed. Furthermore, simple derivatives of the drugs such as ethers, esters, amides, and the like which have desirable retention and release characteristics but which are easily hydrolyzed by body pH, enzymes and the like can be employed. The amount of agent incorporated in the osmotic dispenser varies widely depending on the particular agent, the desired therapeutic effect, and the time span for which it takes the agent to be released. Since a variety of dispensers in a variety of sizes and shapes are intended to provide complete dosage regimens for therapy for a variety of maladies, there is no critical upper limit on the amount of drug incorporated in the dispenser. The lower limit too will depend on the activity of the drug and the time span of its release from the dispenser. Thus it is not practical to define a range for the therapeutically effective amount of drug to be released by the dispenser. Thus, the amount dispensed for active agents such as drug will be the standard amount as described in Pharmacology in Medicine, edited by DiPalma, J.R.., 1965, McGraw-l-lill Book Company, New York; The Pharmacological Basis of Therapeutics, Fourth Edition, by Goodman, LS. and Gilman, A.,
Pharmaceutical Sciences, Fourteenth Edition, i970, Mack Publishing Company, Easton, Penn; and the like. Additionally, the drug can be charged into the device in known forms such as solution, dispersion, cream, emulsion, suspensions, fine powders, and the like. Generally, the device will contain about 0.01 to percent or higher of an agent or a mixture of agent and carriers based on the weight of the agent or agent carriers composition solute to the volume of the device, and the like. Typically, the device can be of such size and shape to release 0.01 cc to 5 cc or higher of agent, usually contained in a pharmaceutical carrier, per hour, day or longer, such as 1 cc to 10 cc of agent composition for l to 10 days, and the like.
The expressions passageway and passageway communicating with" as used herein are comprised of those means and methods suitable for releasing the product from the device under the pumping rate of the device. The expression includes an aperture, orifice, bore, stainless steel needles, hollow cellulose acetate tubes, polyolefin tubes, capillary tubes suitable for passing the agent, tubes and conduits of various inside diameters, closed passageways containing a bioerodible material that erodes in the environment of use to produce an open passageway. Typical bioerodible materials include erodible polyglycolic and polylactic fibers, erodible gelatinous filaments, polyvinyl alcohol, and the like.
The following examples are merely illustrative of the present invention and they should not be considered as limiting the scope of the invention in any way, as these examples and other equivalents thereof will become apparent to those versed in the art in the light of the present disclosure, drawings, and the accompanying claims.
An osmotic dispensing device for the continuous release of active agent and having a diameter volume of microliters was manufactured as follows: first, a section of commerically available heat shrinkable poly- (olefine) such as poly(vinylidene chloride) having an internal diameter three thirty-seconds inches was cut into a 5 cm section. Next, a plug of commerically available Silastic silicone rubber was cut from a rod, with the plug having the following dimensions 3 mm long X 3 mm O.D. wherein 0D. is outside diameter. Then, the plug was inserted into the heat shrinkable tubing and held in position between two solid steel rods. One rod entered the tubing from each of its entrances. The unit was heated at 100C in water and pulled longitudinally until the gap between the plug and the rod was 2 mm longer than a mold cavity used for the pulling step. The mold cavity was 7 mm long,
The tubing containing the plug was cooled to room temperature and clamped into ajsecond mold with a milled cavity and a clamping means for confining the encapsulated silicone rubber.- The mold was closed and heated at 100C in water with pressure applied for 30 seconds through one opening of the tubing to expand the tubing to the dimensions of the cavity. The mold was next cooled and tubing housing the plug and having a cavity was removed from the mold.
Next, an osmotic solute slurry was prepared by mixing 500 grams of analytical reagent grade K 80 powder with 200 ml of 2 wt percent ethyl cellulose in ethanol in a Waring blender at the highest speed for about 2 minutes. The appropriate amount of solute was deposited on 15 chambers by dips in the cooled solute slurry with minute intervals between dips. The slurry coated chambers were placed in a near zero humidity dry box to prevent water absorption during evaporation of solvent. A few of the chambers were optionally dipped in gelatin to smooth any pores and add strength to the solute deposit. When gelatin was applied, the gelatine dip was 15 g in 100 ml of distilled water at 60C. All the coated chambers were dried at least 2 hours. The total solute coat thickness was measured at about 0.27 mm.
Next, the dry solute coated chambers were placed in a dipping box containing an acetone atmosphere for dipping in a freshly prepared cellulose acetate membrane solution comprised of IS wt percent cellulose acetate and 85 wt percent acetone. The chambers were dippsed 14 times with 15 minute intervals between dips to deposit a membrane about 14 mils thick.
Four osmotic dispensing devices manufactured according to the above description were changed with a blue dye solution and the dye release rate measured and charted in accompanying FIGS. 4, 5, 6 and 7. The osmotic pumps were placed in an environment of water which was an external fluid. The dispensed blue dye is measured volumetrically or by using standard otpical laboratory measuring instruments. The results obtained show that after a short start-up period, the osmotic devices uniformly dispense about 0.6 p.l/hr. The prolonged and constant pumping rate is obtained to exhaustion of the chamber, or for about 150 hours, and the total volume dispensed from the devices was about 92 ,LLl. The results for the devices measured as shown in FIGS. 4 7 are seen as evidencing the useful operability of the device for its application in industry and commence.
The novel, osmotic product delivery device of this invention employs a unique means which facilitates the obtainment of precisely conducted agent release rates in the environment of use. While there has been described and pointed out the fundamental novel features of the invention as applied to the presently preferred embodiments, those skilled in the art will appreciate that various modifications changes and omisslons in the osmotic agent devices illustrated and described can be made without departing from the spirit of the invention.
What is claimed is:
1. An osmotic dispenser for dispensing an active agent, wherein said dispenser comprises:
a. an inner wall formed of a fexible material essentially impermeable to solute and external fluid, the
wall surrounding and forming,
b. a compartment defined by the inner surface of the wall as a means for housing an active agent,
c. a layer of an osmotically efi'ective solute deposited on the inner walls outer surface, said solute capable of exhibiting an oxmotic pressure gradient against an external fluid when the dispenser is positioned in the environment of use,
d. an outer wall surrounding the layer of solute, said outer wall formed of a material having shape retaining properties and at least a part of the wall is permeable to external fluid and impermeable to solute,
e. a dispensing passageway communicating with the compartment and the exterior of the device for dispensing an agent from the device,
f. a filling passageway communicating with the exterior of the device and the compartment as a means for charging agent into the compartment,
g. a means positioned in the filling passageway for closing the passageway, said means formed of a material that automatically closes after agent is charged into the compartment through the filling passageway.
2. An improved osmoticdispenser for dispensing an active agent according to claim 1 wherein the inner wall material is a heat shrinkable polymeric material.
3. An improved osmotic dispenser for dispensing an active agent according to claim 1 wherein the automatic closing material is an elastomeric material.
4. An improved osmotic dispenser for dispensing an active agent'according to claim 1 wherein the filling passageway is formed of a heat shrinkable polymer in intimate contact with the automatic closing material formed of an elastomeric material.
5. An improved osmotic dispenser for dispensing an active agent according to claim 1 wherein in operation in the environment of use, agent is dispensed from the dispensor by external fluid permeating from the exterior through the permeable outer wall continuously dissolving the solute in a tendency toward osmotic equilibrium with the environment to continually increase the volume between the outer wall and the compartment generating a mechanical or hydrostatic force to cause the compartment to continuously collapse and dispense agent from the device at a controlled rate over a prolonged period of time through the dispensing passageway with essentially no agent dispensed through the filling passageway.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3604417 *||Mar 31, 1970||Sep 14, 1971||American Cyanamid Co||Osmotic fluid reservoir for osmotically activated long-term continuous injector device|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3865108 *||Jul 9, 1973||Feb 11, 1975||Ortho Pharma Corp||Expandable drug delivery device|
|US3880164 *||May 22, 1972||Apr 29, 1975||Alza Corp||Osmotic wound drain|
|US3894538 *||Aug 6, 1973||Jul 15, 1975||Siemens Ag||Device for supplying medicines|
|US3952741 *||Jan 9, 1975||Apr 27, 1976||Bend Research Inc.||Controlled release delivery system by an osmotic bursting mechanism|
|US3987790 *||Oct 1, 1975||Oct 26, 1976||Alza Corporation||Osmotically driven fluid dispenser|
|US3995631 *||Sep 25, 1972||Dec 7, 1976||Alza Corporation||Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient|
|US4031202 *||Dec 8, 1975||Jun 21, 1977||The Procter & Gamble Company||Controlled release contraceptive article|
|US4034756 *||Mar 12, 1976||Jul 12, 1977||Alza Corporation||Osmotically driven fluid dispenser|
|US4054138 *||May 12, 1976||Oct 18, 1977||Louis Bucalo||Implants for acting on living beings|
|US4073833 *||Dec 8, 1975||Feb 14, 1978||The Procter & Gamble Company||Encapsulation process|
|US4111201 *||Nov 22, 1976||Sep 5, 1978||Alza Corporation||Osmotic system for delivering selected beneficial agents having varying degrees of solubility|
|US4111202 *||Nov 22, 1976||Sep 5, 1978||Alza Corporation||Osmotic system for the controlled and delivery of agent over time|
|US4111203 *||Nov 22, 1976||Sep 5, 1978||Alza Corporation||Osmotic system with means for improving delivery kinetics of system|
|US4177256 *||Nov 29, 1977||Dec 4, 1979||Alza Corporation||Osmotic bursting drug delivery device|
|US4180073 *||Aug 29, 1977||Dec 25, 1979||Alza Corporation||Device for delivering drug to biological environment|
|US4203440 *||Oct 23, 1978||May 20, 1980||Alza Corporation||Device having variable volume chamber for dispensing useful agent|
|US4203442 *||Jan 4, 1979||May 20, 1980||Alza Corporation||Device for delivering drug to a fluid environment|
|US4207893 *||Dec 26, 1978||Jun 17, 1980||Alza Corporation||Device using hydrophilic polymer for delivering drug to biological environment|
|US4223061 *||Oct 25, 1977||Sep 16, 1980||Alza Corporation||Hydrophilic laminate useful for making dispensing device|
|US4237893 *||Nov 28, 1979||Dec 9, 1980||Alza Corporation||Cervical dilator|
|US4304232 *||Jan 28, 1980||Dec 8, 1981||Alza Corporation||Unit system having multiplicity of means for dispensing useful agent|
|US4432756 *||Nov 27, 1981||Feb 21, 1984||Alza Corporation||Parenteral controlled therapy|
|US4473370 *||Sep 14, 1981||Sep 25, 1984||Weiss Jeffrey N||Protective eye shield|
|US4479793 *||Oct 11, 1983||Oct 30, 1984||Alza Corporation||Parenteral administration using drug delivery device|
|US4479794 *||Oct 11, 1983||Oct 30, 1984||Alza Corporation||System for intravenous therapy|
|US4484909 *||Oct 17, 1983||Nov 27, 1984||Alza Corporation||Parenteral therapy using solid drug|
|US4493702 *||Oct 17, 1983||Jan 15, 1985||Alza Corporation||Parenteral administration using osmotically motivated delivery system|
|US4511351 *||May 14, 1984||Apr 16, 1985||Alza Corporation||Parenteral delivery system utilizing a hollow fiber cellular unit|
|US4511352 *||May 14, 1984||Apr 16, 1985||Alza Corporation||Parenteral delivery system with in-line container|
|US4511353 *||Oct 9, 1981||Apr 16, 1985||Alza Corporation||Intravenous system for delivering a beneficial agent|
|US4515585 *||Oct 31, 1983||May 7, 1985||Alza Corporation||System for parenteral administration of agent|
|US4525162 *||Mar 9, 1984||Jun 25, 1985||Alza Corporation||Parenteral controlled delivery|
|US4548599 *||Jan 5, 1984||Oct 22, 1985||Alza Corporation||Parenteral controlled therapy|
|US4552556 *||Jan 4, 1985||Nov 12, 1985||Alza Corporation||Parenteral controlled therapy|
|US4579553 *||Jan 7, 1985||Apr 1, 1986||Alza Corporation||Parenteral controlled therapy|
|US4583981 *||Jan 7, 1985||Apr 22, 1986||Alza Corporation||Parenteral controlled therapy, using a porous matrix with parenteral agent|
|US4586922 *||Feb 15, 1985||May 6, 1986||Alza Corporation||Intravenous system for delivering a beneficial agent|
|US4596555 *||Jan 28, 1985||Jun 24, 1986||Alza Corporation||Parenteral delivery system utilizing a hollow fiber cellular unit|
|US4663148 *||Feb 14, 1986||May 5, 1987||Alza Corporation||Dispenser comprising telescopically engaging members|
|US4663149 *||Feb 14, 1986||May 5, 1987||Alza Corporation||Dispenser comprising inner and outer walls functioning as cooperative unit|
|US4664650 *||Oct 31, 1983||May 12, 1987||Alza Corporation||Apparatus for parenteral infusion of fluid containing beneficial agent|
|US4692326 *||Feb 14, 1986||Sep 8, 1987||Alza Corporation||Dispenser comprising inner positioned soft or hard capsule|
|US4716031 *||Feb 12, 1986||Dec 29, 1987||Alza Corporation||Drug dispenser comprising a multiplicity of members acting together for successfully dispensing drug|
|US4740103 *||Feb 15, 1985||Apr 26, 1988||Alza Corporation||Intravenous system for delivering a beneficial agent|
|US4740197 *||Feb 14, 1985||Apr 26, 1988||Alza Corporation||Intravenous system for delivering a beneficial agent via polymer delivery|
|US4740198 *||Feb 15, 1985||Apr 26, 1988||Alza Corporation||Method of administering intravenous drug using rate-controlled dosage form|
|US4740199 *||Feb 14, 1985||Apr 26, 1988||Alza Corporation||Intravenous system for delivering a beneficial agent|
|US4740200 *||Feb 15, 1985||Apr 26, 1988||Alza Corporation||Intravenous system for delivering a beneficial agent|
|US4740201 *||Feb 19, 1985||Apr 26, 1988||Alza Corporation||Intravenous system for delivering a beneficial agent|
|US4741734 *||Feb 15, 1985||May 3, 1988||Alza Corporation||Releasing means for adding agent using releasing means to IV fluid|
|US4741735 *||Feb 14, 1985||May 3, 1988||Alza Corporation||Intravenous system for delivering a beneficial agent|
|US4790820 *||Oct 25, 1984||Dec 13, 1988||Alza Corporation||Parenteral agent dispensing equipment with drug releasing member|
|US4800056 *||Feb 14, 1986||Jan 24, 1989||Alza Corporation||Process for making dispenser with cooperating elements|
|US4814180 *||Dec 15, 1986||Mar 21, 1989||Alza Corporation||Agent dispenser comprising a semipermeable wall surrounding single-piece or two-piece container|
|US4857052 *||May 4, 1987||Aug 15, 1989||Alza Corporation||Intravenous system for delivering a beneficial agent|
|US4865845 *||Aug 28, 1987||Sep 12, 1989||Alza Corporation||Release rate adjustment of osmotic or diffusional delivery devices|
|US4871360 *||Apr 21, 1986||Oct 3, 1989||Alza Corporation||System for intravenous delivery of a beneficial drug at a regulated rates|
|US4908019 *||Sep 16, 1988||Mar 13, 1990||Alza Corporation||Apparatus comprising dual reservoirs for parenteral infusion of fluid containing beneficial agent|
|US4929233 *||Aug 26, 1988||May 29, 1990||Alza Corporation||Implantable fluid imbibing pump with improved closure|
|US4946456 *||Aug 26, 1988||Aug 7, 1990||Alza Corp.||Fluid imbibing pump activated by capillary action of a fabric or polymeric sleeve|
|US4969872 *||Mar 8, 1989||Nov 13, 1990||Alza Corporation||Intravenous system for delivering a beneficial agent with delivery rate control via permeable surface area variance|
|US4969884 *||Dec 28, 1988||Nov 13, 1990||Alza Corporation||Osmotically driven syringe|
|US4973307 *||Apr 25, 1989||Nov 27, 1990||Alza Corporation||Method for administering drugs to a patient|
|US4976966 *||Dec 29, 1988||Dec 11, 1990||Alza Corporation||Delayed release osmotically driven fluid dispenser|
|US4985017 *||Apr 25, 1989||Jan 15, 1991||Alza Corporation||Parenteral therapeutical system comprising drug cell|
|US4994031 *||Apr 17, 1989||Feb 19, 1991||Alza Corporation||Intravenous system for delivering a beneficial agent|
|US5024657 *||May 4, 1990||Jun 18, 1991||Baxter International Inc.||Drug delivery apparatus and method preventing local and systemic toxicity|
|US5024663 *||Feb 21, 1990||Jun 18, 1991||Alza Corporation||Self-contained suction pump|
|US5030203 *||Nov 16, 1987||Jul 9, 1991||Baxter International Inc.||Ampule for controlled administration of beneficial agent|
|US5030216 *||Dec 15, 1989||Jul 9, 1991||Alza Corporation||Osmotically driven syringe|
|US5069671 *||Jun 23, 1988||Dec 3, 1991||Alza Corporation||Intravenous medication|
|US5151093 *||Oct 29, 1990||Sep 29, 1992||Alza Corporation||Osmotically driven syringe with programmable agent delivery|
|US5279608 *||Dec 4, 1991||Jan 18, 1994||Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)||Osmotic pumps|
|US5312389 *||Apr 3, 1992||May 17, 1994||Felix Theeuwes||Osmotically driven syringe with programmable agent delivery|
|US5540665 *||Jan 31, 1994||Jul 30, 1996||Alza Corporation||Gas driven dispensing device and gas generating engine therefor|
|US5972369 *||Mar 30, 1998||Oct 26, 1999||Alza Corporation||Diffusional implantable delivery system|
|US6180129 *||Oct 23, 1997||Jan 30, 2001||Alza Corporation||Polyurethane-containing delivery systems|
|US6251432||Jul 1, 1999||Jun 26, 2001||Abbott Laboratories||Sustained release dosage form unit having latex coating and method of making the same|
|US6347934||May 10, 2000||Feb 19, 2002||E. Khashoggi Industries, Llc.||System for metering and delivering a moldable composition into a mold|
|US6464688||Feb 15, 2000||Oct 15, 2002||Microsolutions, Inc.||Osmotic pump delivery system with flexible drug compartment|
|US6471688||Feb 15, 2000||Oct 29, 2002||Microsolutions, Inc.||Osmotic pump drug delivery systems and methods|
|US6541021||Mar 10, 2000||Apr 1, 2003||Durect Corporation||Devices and methods for pain management|
|US6616652||Feb 15, 2000||Sep 9, 2003||Microsolutions, Inc.||Osmotic pump delivery system with pre-hydrated membrane(s) and/or primable catheter|
|US6620434||May 10, 2001||Sep 16, 2003||Abbott Laboratories||Sustained release dosage form unit having latex coating and method of making the same|
|US6627631 *||Feb 8, 2000||Sep 30, 2003||Lts Lohmann Therapie-Systeme Ag||Pharmaceutical composition containing desoxypeganine for the treatment of alcoholism|
|US6632217||Apr 19, 2001||Oct 14, 2003||Microsolutions, Inc.||Implantable osmotic pump|
|US6689373||Nov 26, 2002||Feb 10, 2004||Durect Corporation||Devices and methods for pain management|
|US6775570||Apr 18, 2002||Aug 10, 2004||Ceramatec, Inc.||Iontophoretic treatment device|
|US6835194||Jun 27, 2002||Dec 28, 2004||Durect Corporation||Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners|
|US6977074||Feb 2, 2001||Dec 20, 2005||Mannkind Corporation||Method of inducing a CTL response|
|US6994851||Jul 10, 1998||Feb 7, 2006||Mannkind Corporation||Method of inducing a CTL response|
|US7047069||Feb 4, 2002||May 16, 2006||Ceramatec, Inc.||Iontophoretic fluid delivery device|
|US7117870 *||Jul 26, 2004||Oct 10, 2006||Clarity Corporation||Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same|
|US7254449||Jan 27, 2006||Aug 7, 2007||Advanced Bionics Corp||Systems and methods for providing power to one or more implantable devices|
|US7335193||Jul 6, 2004||Feb 26, 2008||Durect Corporation||Osmotically-driven fluid dispenser|
|US7347746||Oct 27, 2006||Mar 25, 2008||Boston Scientific Neuromodulation Corporation||Receptacle connector assembly|
|US7349733||Nov 2, 2001||Mar 25, 2008||Ceramatel, Inc.||Iontophoretic drug delivery systems|
|US7364729||Dec 19, 2005||Apr 29, 2008||Mannkind Corporation||Method of inducing a CTL response|
|US7407973||Oct 21, 2004||Aug 5, 2008||Intermune, Inc.||Use of pirfenidone in therapeutic regimens|
|US7445528||Sep 29, 2006||Nov 4, 2008||Boston Scientific Neuromodulation Corporation||Connector assemblies|
|US7483746||Dec 6, 2005||Jan 27, 2009||Boston Scientific Neuromodulation Corp.||Stimulation of the stomach in response to sensed parameters to treat obesity|
|US7493172||Mar 4, 2005||Feb 17, 2009||Boston Scientific Neuromodulation Corp.||Methods and systems for stimulating a nerve originating in an upper cervical spine area to treat a medical condition|
|US7610100||Dec 30, 2005||Oct 27, 2009||Boston Scientific Neuromodulation Corporation||Methods and systems for treating osteoarthritis|
|US7684858||Sep 21, 2005||Mar 23, 2010||Boston Scientific Neuromodulation Corporation||Methods and systems for placing an implanted stimulator for stimulating tissue|
|US7729758||Nov 30, 2005||Jun 1, 2010||Boston Scientific Neuromodulation Corporation||Magnetically coupled microstimulators|
|US7769461||Dec 17, 2004||Aug 3, 2010||Boston Scientific Neuromodulation Corporation||Skull-mounted electrical stimulation system and method for treating patients|
|US7777641||Mar 29, 2006||Aug 17, 2010||Advanced Bionics, Llc||Systems and methods of facilitating communication between a first and second device|
|US7799037||Feb 11, 2003||Sep 21, 2010||Boston Scientific Neuromodulation Corporation||Surgical insertion tool|
|US7835803||Jan 17, 2007||Nov 16, 2010||Boston Scientific Neuromodulation Corporation||Lead assemblies with one or more switching networks|
|US7846332 *||Jun 25, 2007||Dec 7, 2010||Mainstream Engineering Corporation||Apparatus and method for self-heating and self-hydrating foods and beverages|
|US7848803||Mar 26, 2007||Dec 7, 2010||Boston Scientific Neuromodulation Corporation||Methods and systems for facilitating stimulation of one or more stimulation sites|
|US7853321||Oct 25, 2005||Dec 14, 2010||Boston Scientific Neuromodulation Corporation||Stimulation of a stimulation site within the neck or head|
|US7890176||Jun 17, 2005||Feb 15, 2011||Boston Scientific Neuromodulation Corporation||Methods and systems for treating chronic pelvic pain|
|US7920915||Nov 16, 2005||Apr 5, 2011||Boston Scientific Neuromodulation Corporation||Implantable stimulator|
|US7963935 *||Apr 20, 2002||Jun 21, 2011||Alza Corporation||Microprojection array having a beneficial agent containing coating|
|US8095219||Jan 23, 2009||Jan 10, 2012||Boston Scientific Neuromodulation Corporation||Stimulation of the stomach in response to sensed parameters to treat obesity|
|US8175710||Mar 14, 2006||May 8, 2012||Boston Scientific Neuromodulation Corporation||Stimulator system with electrode array and the method of making the same|
|US8197844||Jun 8, 2007||Jun 12, 2012||Activatek, Inc.||Active electrode for transdermal medicament administration|
|US8214058||Oct 12, 2010||Jul 3, 2012||Boston Scientific Neuromodulation Corporation||Lead assemblies with one or more switching networks|
|US8224451||Nov 17, 2010||Jul 17, 2012||Boston Scientific Neuromodulation Corporation||Methods and systems for facilitating stimulation of one or more stimulation sites|
|US8315704||Nov 5, 2010||Nov 20, 2012||Boston Scientific Neuromodulation Corporation||Stimulation of a stimulation site within the neck or head|
|US8364280||Jul 21, 2009||Jan 29, 2013||Boston Scientific Neuromodulation Corporation||Engagement tool for implantable medical devices|
|US8372393||May 3, 2006||Feb 12, 2013||Mannkind Corporation||Method of inducing a CTL response|
|US8401634||Aug 31, 2010||Mar 19, 2013||Boston Scientific Neuromodulation Corporation||Treatment of movement disorders by brain stimulation|
|US8401654||Jun 30, 2006||Mar 19, 2013||Boston Scientific Neuromodulation Corporation||Methods and systems for treating one or more effects of deafferentation|
|US8404653||Nov 13, 2006||Mar 26, 2013||Enterprise Partners Venture Capital||Membrane bound stem cell factor therapy for ischemic heart|
|US8423154||Jun 12, 2012||Apr 16, 2013||Boston Scientific Neuromodulation Corporation||Lead assemblies with one or more switching networks|
|US8423155||Aug 8, 2008||Apr 16, 2013||Boston Scientific Neuromodulation Corporation||Methods and systems for facilitating stimulation of one or more stimulation sites|
|US8452407||Jul 29, 2005||May 28, 2013||Boston Scientific Neuromodulation Corporation||Methods for treating gastrointestinal disorders|
|US8504163||Jun 30, 2006||Aug 6, 2013||Boston Scientific Neuromodulation Corporation||Cranially mounted stimulation systems and methods|
|US8515541||Dec 22, 2005||Aug 20, 2013||Boston Scientific Neuromodulation Corporation||Methods and systems for treating post-stroke disorders|
|US8630705||Mar 21, 2011||Jan 14, 2014||Boston Scientific Neuromodulation Corporation||Implantable stimulator|
|US8644954||Apr 15, 2013||Feb 4, 2014||Boston Scientific Neuromodulation Corporation||Methods and systems for facilitating stimulation of one or more stimulation sites|
|US8862223||Jan 18, 2008||Oct 14, 2014||Activatek, Inc.||Active transdermal medicament patch and circuit board for same|
|US9095713||Jun 30, 2006||Aug 4, 2015||Allison M. Foster||Methods and systems for treating autism by decreasing neural activity within the brain|
|US9138569||Feb 26, 2013||Sep 22, 2015||SinuSys Corporation||Devices and methods for dilating a paranasal sinus opening and for treating sinusitis|
|US9149616||May 20, 2013||Oct 6, 2015||SinuSys Corporation||Devices and methods for dilating a paranasal sinus opening and for treating sinusitis|
|US20010047161 *||Jan 30, 2001||Nov 29, 2001||Wong Patrick S.L.||Osmotically-driven fluid dispenser and composition|
|US20020007173 *||Feb 2, 2001||Jan 17, 2002||Kundig Thomas M.||Method of inducing a CTL response|
|US20020151876 *||Feb 7, 2002||Oct 17, 2002||Tai-Wah Chan||Devices and methods for management of bone density|
|US20020177839 *||Apr 20, 2002||Nov 28, 2002||Cormier Michel J. N.||Microprojection array having a beneficial agent containing coating|
|US20030088204 *||Nov 2, 2001||May 8, 2003||Joshi Ashok V||Novel iontophoretic drug delivery systems|
|US20030088236 *||Jun 27, 2002||May 8, 2003||Johnson Randolph Mellus||Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners|
|US20030135202 *||Jan 17, 2003||Jul 17, 2003||Microsolutions, Inc.||Implantable osmotic pump|
|US20040102476 *||Nov 25, 2002||May 27, 2004||Chan Tai Wah||High concentration formulations of opioids and opioid derivatives|
|US20040157884 *||Nov 20, 2003||Aug 12, 2004||Johnson Randolph Mellus||Devices and methods for pain management|
|US20040230183 *||Feb 18, 2004||Nov 18, 2004||Wisam Breegi||Drug delivery device and syringe for filling the same|
|US20040249365 *||Oct 14, 2003||Dec 9, 2004||Microsolutions, Inc.||Implantable osmotic pump|
|US20050070883 *||Nov 21, 2001||Mar 31, 2005||Brown James E||Devices and methods for controlled delivery from a drug delivery device|
|US20050106205 *||Aug 18, 2004||May 19, 2005||Gillis Edward M.||Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners|
|US20050118246 *||Oct 29, 2004||Jun 2, 2005||Wong Patrick S.||Dosage forms and layered deposition processes for fabricating dosage forms|
|US20050129737 *||Jan 26, 2005||Jun 16, 2005||Johnson Randolph M.||Devices and methods for pain management|
|US20050143789 *||Feb 25, 2005||Jun 30, 2005||Whitehurst Todd K.||Methods and systems for stimulating a peripheral nerve to treat chronic pain|
|US20050154419 *||Mar 4, 2005||Jul 14, 2005||Whitehurst Todd K.||Methods and systems for stimulating a nerve originating in an upper cervical spine area to treat a medical condition|
|US20050187530 *||May 31, 2001||Aug 25, 2005||Davidson Roderick I.||Super absorbent driven dispenser|
|US20050228451 *||Jun 17, 2005||Oct 13, 2005||Jaax Kristen N||Methods and systems for treating chronic pelvic pain|
|US20060020248 *||Jul 26, 2004||Jan 26, 2006||Prescott Anthony D||Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same|
|US20060020253 *||Jul 26, 2004||Jan 26, 2006||Prescott Anthony D||Implantable device having reservoir with controlled release of medication and method of manufacturing the same|
|US20060036293 *||Jul 29, 2005||Feb 16, 2006||Whitehurst Todd K||Methods for treating gastrointestinal disorders|
|US20060064140 *||Oct 7, 2005||Mar 23, 2006||Whitehurst Todd K||Methods and systems for stimulating a trigeminal nerve to treat a psychiatric disorder|
|US20060129201 *||Dec 6, 2005||Jun 15, 2006||Lee Philip H J||Stimulation of the stomach in response to sensed parameters to treat obesity|
|US20060149340 *||Jan 27, 2006||Jul 6, 2006||Karunasiri Rankiri T||Systems and methods for providing power to one or more implantable devices|
|US20060153844 *||Dec 29, 2005||Jul 13, 2006||Thomas Kundig||Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs|
|US20060153858 *||Dec 19, 2005||Jul 13, 2006||Kundig Thomas M||Method of inducing a CTL response|
|US20060161217 *||Dec 21, 2005||Jul 20, 2006||Jaax Kristen N||Methods and systems for treating obesity|
|US20060185665 *||Feb 22, 2005||Aug 24, 2006||Bachinski Thomas J||Sauna fireplace|
|US20060194724 *||Feb 25, 2005||Aug 31, 2006||Whitehurst Todd K||Methods and systems for nerve regeneration|
|US20060206165 *||Oct 21, 2005||Sep 14, 2006||Jaax Kristen N||Occipital nerve stimulation to treat headaches and other conditions|
|US20060235484 *||Oct 25, 2005||Oct 19, 2006||Jaax Kristen N||Stimulation of a stimulation site within the neck or head|
|US20060247728 *||Jun 30, 2006||Nov 2, 2006||Foster Allison M||Methods and systems for treating autism by decreasing neural activity within the brain|
|US20060264913 *||Jun 27, 2006||Nov 23, 2006||Poutiatine Andrew I||Implantable flow regulator with failsafe mode and reserve drug supply|
|US20070014820 *||Jun 27, 2006||Jan 18, 2007||Dana Litmanovitz||Opioid formulations|
|US20070049988 *||Dec 30, 2005||Mar 1, 2007||Rafael Carbunaru||Optimal electrode contact polarity configurations for implantable stimulation systems|
|US20070066997 *||Sep 21, 2005||Mar 22, 2007||He Tom X||Methods and systems for placing an implanted stimulator for stimulating tissue|
|US20070083240 *||Dec 7, 2006||Apr 12, 2007||Peterson David K L||Methods and systems for applying stimulation and sensing one or more indicators of cardiac activity with an implantable stimulator|
|US20070112404 *||Nov 16, 2005||May 17, 2007||Mann Alfred E||Implantable stimulator|
|US20070117841 *||Oct 21, 2004||May 24, 2007||Ozes Osman N||Use of pirfenidone in therapeutic regimens|
|US20070156180 *||Dec 30, 2005||Jul 5, 2007||Jaax Kristen N||Methods and systems for treating osteoarthritis|
|US20070250136 *||Mar 29, 2006||Oct 25, 2007||Karunasiri Rankiri T||Systems and methods of facilitating communication between a first and second device|
|US20080027513 *||Jul 8, 2005||Jan 31, 2008||Advanced Bionics Corporation||Systems And Methods For Using A Butterfly Coil To Communicate With Or Transfer Power To An Implantable Medical Device|
|US20080102119 *||Nov 1, 2006||May 1, 2008||Medtronic, Inc.||Osmotic pump apparatus and associated methods|
|US20080131398 *||Aug 21, 2007||Jun 5, 2008||United Therapeutics Corporation||Combination therapy for treatment of viral infections|
|US20080177219 *||Jan 23, 2007||Jul 24, 2008||Joshi Ashok V||Method for Iontophoretic Fluid Delivery|
|US20080249497 *||Oct 10, 2007||Oct 9, 2008||Wong Patrick S L||Osmotically-driven fluid dispenser|
|US20120237353 *||Sep 22, 2010||Sep 20, 2012||Ecp Entwicklungsgesellschaft Mbh||Compressible rotor for a fluid pump|
|USRE34365 *||Aug 5, 1991||Aug 31, 1993||Intravenous system for delivering a beneficial agent|
|DE2640904A1 *||Sep 10, 1976||Mar 24, 1977||Alza Corp||Vorrichtung zur abgabe von wirkstoffen durch osmose und verfahren zu deren herstellung|
|DE2644267A1 *||Sep 30, 1976||Apr 14, 1977||Alza Corp||Vorrichtung zur abgabe einer fluessigkeit durch osmose|
|DE3228595A1 *||Jul 30, 1982||Feb 17, 1983||Alza Corp||System zur parenteralen verabreichung eines wirkstoffs|
|DE3634864A1 *||Oct 13, 1986||Apr 14, 1988||Alza Corp||Abgabevorrichtung zur freisetzung einer auf temperatur ansprechenden masse|
|EP0048541A1 *||Jun 30, 1981||Mar 31, 1982||Alza Corporation||Osmotically driven fluid dispenser|
|EP0259013A1||Aug 4, 1987||Mar 9, 1988||Pharmetrix Corporation||Portable controlled release osmotic infusion device|
|EP1304105A2 *||Mar 17, 1998||Apr 23, 2003||Alza Corporation||Diffusional implantable delivery system|
|EP2390262A1||May 13, 2004||Nov 30, 2011||Intermune, Inc.||Synthetic chemokine receptor ligands and methods of use thereof|
|WO1998043611A1 *||Mar 17, 1998||Oct 8, 1998||Alza Corp||Diffusional implantable delivery system|
|WO2001026714A1||Oct 12, 2000||Apr 19, 2001||Brown James E||Regulation of drug delivery through flow diversion|
|WO2002043800A2||Nov 21, 2001||Jun 6, 2002||James E Brown||Devices and methods for controlled delivery from a drug delivery device|
|WO2004022069A1||Sep 6, 2002||Mar 18, 2004||Yves Christen||Delivery of modulators of glutamate-mediated neurotransmission to the inner ear|
|WO2007059010A2||Nov 13, 2006||May 24, 2007||Entpr Partners Venture Capital||Stem cell factor therapy for tissue injury|
|WO2012175698A1||Jun 22, 2012||Dec 27, 2012||Université Libre de Bruxelles||Therapeutic use of all-trans retinoic acid (atra) in patients suffering from alcoholic liver disease|
|WO2013033636A2||Aug 31, 2012||Mar 7, 2013||University Of Southern California||Methods for preparing high throughput peptidomimetics, orally bioavailable drugs and compositions containing same|
|WO2015085312A1||Dec 8, 2014||Jun 11, 2015||Durect Corporation||Compositions comprising antioxidant, fluid dispensers, and methods involving the same|
|U.S. Classification||222/95, 222/386.5, 222/389, 604/892.1|
|International Classification||B01J4/04, A61K9/00, B65D37/00|
|Cooperative Classification||B01D61/002, A61K9/0004, B01D61/005|
|European Classification||B01D61/00B, B01D61/00B10, A61K9/00L4|