|Publication number||US3788327 A|
|Publication date||Jan 29, 1974|
|Filing date||Mar 30, 1971|
|Priority date||Mar 30, 1971|
|Publication number||US 3788327 A, US 3788327A, US-A-3788327, US3788327 A, US3788327A|
|Original Assignee||Donowitz H, Hara W|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (8), Non-Patent Citations (3), Referenced by (232), Classifications (12) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Surgical implant device
US 3788327 A
Disclosed implant device includes a valve and conduit means for controlling the intra-occular pressure build up in a diseased eye.
United States Patent [1 1 Donowitz et a1.
[ Jan. 29, 1974 SURGICAL IMPLANT DEVICE  Inventors: Howard Donowitz, Box 218, R.D.
No. 1; William J. OHara, 23 Hampton Dr., both of Freehold, NJ. 07728  Filed: Mar. 30, 1971  Appl. No.: 129,384
 U.S. Cl 128/350 R  Int. Cl. A61m 27/00, A61m 25/00  Field of Search 128/348, 350 R, 350 V  References Cited UNITED STATES PATENTS 2,867,213 1/1959 Thomas, Jr. 128/350 V 3,333,588 8/1967 Schulte 128/350 R 274,447 3/1883 Kennish 128/348 UX 733,152 7/1903 Chisholm 128/350 V 1,388,172 8/1921 Craddock 128/348 3,159,161 12/1964 Ness 128/350 R 3,421,509 1/1969 Fiore 128/349 R 6/1856 Peale 3/D1G. 3
OTHER PUBLICATIONS Teflon Armstrong Beveled Drain Tube, Advertisement of Richards Mfg. Co., Memphis, Tenn. Copyright Primary Examiner-Channing L. Pace Attorney, Agent, or Firm-Leonard R. Fellen ABSTRACT Disclosed implant device includes a valve and conduit means for controlling the intra-occular pressure build up in a diseased eye.
7 Claims, 6 Drawing Figures PATENTED JAN29 I974 INVENTORS HOWARD DONPWITZ O,E' WILLIAM J. OHARA ATTORNEY SURGICAL IMPLANT DEVICE This invention relates generally to surgical devices and more particularly to a surgical device to be implanted in an eye for controlling intra-occular pressure, as, for example, in a glaucoma diseased eye wherein there is an increased pressure built up within the eye from the accumulation of fluid.
Normally, fluid called aqueous humor, which constantly forms and enters portions of the eye globe known as the anterior and posterior chambers, are balanced by those fluids which leave the eye by drainage through the canal of Schlemm. In glaucoma, for example, more fluid is secreted than is discharged, which results in an increase in intra-occular pressure, causing pain, interference with vision, and eventual blindness. In acute and chronic cases of glaucoma, this fluid imbalance is usually due to a blockage of the canal of Schlemm from a change in the character of the filtering or drainage tissues or a collapse of the angle of the anterior chamber.
Many surgical procedures for treating acute and chronic glaucoma and involving incisions and device implants have been proposed or tried, all of which has met with rather varied and inconsistent results. One such device includes, for example, an elongated tubular section curved to the same radius as an eye and an attached right angled section including a bore and adapted for insertion into a hole surgically drilled in an eye so as to provide for the drainage of fluid through the device into the retrobulbar space behind the eye.
Particular problems and disadvantages apparent in this and other prior art devices are the general lack of any provisions in the devices to safeguard against excessive drainage of fluid which could bring about a collapse of the anterior chamber causing a possible loss of sight or the eye itself. The drilling of a hole, for example, for receiving the right angled section for the abovedescribed device may in itself cause an excessive loss of fluid. Also, devices of the type including an extended bore or continuous open channel for fluid drainage also provide a means for the outside entry of harmful bacteria into the anterior chamber, with a possible resulting infection of the eye.
It is an object of the present invention to provide an implant device which is simple in construction, free of the aforementioned disadvantages and effective in controlling excessive intra-occular pressure.
It is another object of the present invention to provide a device which when surgically implanted in a glaucomatic eye operates in a manner to relieve an excessive intra-occular pressure.
It is another object of the present invention to provide a device which when implanted in a glaucoma diseased eye serves as a drain for excess fluid built up in the anterior and posterior chambers.
Briefly described, the implant device of the present invention includes an elongated shank member have a passageway axially extending therethrough and mounting a valve therein to normally provide for closure of the passageway, the valve opening in response to a predetermined pressure differential within the passageway. A flange is provided on one end of the shank member to anchor the implant device. Means are also provided on the shank member for insuring retention of the device in the eye.
The novel features which are considered to be characteristic of the invention are set forth with particularity in the appended claims. The invention itself, however, both as to its organization and method of operation as well as additional objects and advantages thereof, will best be understood from the following description when read in connection with the accompanying drawing in which:
FIG. 1 is a vertical section of a human eye showing the device of the present invention implanted therein;
FIG. 2 is a perspective view of the implant device of the invention;
FIG. 3 is a top view of the device of FIG. 2;
FIG. 4 is an enlarged front sectional view taken along the lines 4-4 of FIG. 3;
FIG. 5 is an enlarged section of the valve area shown in FIG. 4; and
FIG. 6 is a modified front sectional view of the flange and upper shank portion of the device.
Referring now to the drawing, and to FIG. 1 thereof, there is illustrated a human eyeball which includes the lens 10, posterior chamber 12, anterior chamber 14, iris 16, sclera 18, canal of Schlemm 20, cornea 22, and the conjunctiva 24 of the eye. As shown in the Figure, the device 26 of the present invention when implanted in the eye preferably extends through the cornea 22 and into the anterior chamber 14 of the eye.
With reference particularly now to FIGS. 2, 3, 4 and 5 in the drawing, a preferred embodiment of an implant device in accordance with the present invention comprises an elongated body or shank portion 28 generally cylindrical in shape, slightly tapered, and having a bore or passageway 30 extending axially therethrough. One end 32 of the shank portion 28 is capped by an integrally formed circular flange 34 with the passageway opening therethrough. The other end of the passageway opens through the bottom portion 36 of the shank 28 which has an obliquely slanted end face 38 to facilitate implantation of the device 26 into an eye as will hereinafter be described.
As shown particularly in FIG. 4, the flange portion 34 is preferably slanted or obliquely positioned relative to the longitudinal axis of the shank portion and has its top and bottom surfaces 40 and 42 arcuately contoured so as to conform generally to the cornea or other portion of the eyeball surface into which the device is to be implanted. The flange portion 34 being seated thereon thus serves to prevent the implant device from being submerged into the eye after insertion.
In spaced array along the periphery of the flange portion 34 are a plurality of apertures 44. Spaced downwardly from the flange portion 34 and extending up and outwardly from the outside surface of the shank portion 28 are a pair of integrally formed projections or barbs 46 which may serve as a means for retaining the device in the eye after implantation. It is important that the barbs 46 be spaced sufficiently beneath the underside of the flange so as to accommodate therebetween the wall thickness of the cornea or other portion of the eyeball receiving the implant device, or alternately be spaced so as to lock within the stroma or mid point of the cornea.
In accordance with the invention, a valve means 48 is provided and seated within the shank passageway 30 so as to normally provide for a closure of the passageway, and for opening in response to a predetermined pressure differential within the passageway and on opposing portions of the valve means.
More particularly, and as shown in FIG. 5, a preferred valve means includes a pair of opposing flexible web or reed-like members 50 and 52 formed integral with and extending out from the inside wall surfaces bounding the passageway 30 and normally abutting one another so as to close off the passageway and inhibit any flow therethrough. Preferably the valve is formed in the shank portion at a point intermediate the ends thereof. The abutting engagement of the reed members 50 and 52 is such that the valve functions in a one-way manner by allowing for the upward deflection of the reed members 50 and 52 in response to the presence of a predetermined increase in pressure exerted on the bottom surfaces 54 and 56 (as viewed in the Figures) of the reed members relative to the pressure exerted on the top surfaces 58 and 60 of the reed members.
It will be appreciated that in fabricating the: device of the invention, the material chosen must be inert and nontoxic. Also it is desirable that the material be somewhat resilient so as to allow for an integral formation within the internal passageway of a one-way valve. One material that has proved satisfactory for this purpose is manufactured by the DuPont Company, under the trade name Teflon. The double reed valve may be fabricated, for example, by machining the shank portion bore from both ends to provide a diaphragm like membrane between the bored end portions. The membrane is then pierced to create a double reed type valve. Piercing of the membrane is from the bottom end of the bore such that the reed valve operates to open only toward the top or flange end of the shank, thereby functioning as a one-way type valve. The valve is thus dependent on the memory retention or resiliency of the material of which it is formed, in addition to the back pressure exerted on the flange side of the valve, to return to its seat or closed position.
It should be noted that the pressure differential or program setting to which the valve openly responds is determined by the thickness of the membrane forming the reed members, the general characteristics and resiliency of the material used in fabricating the device as well as the size of the bore opening or passageway.
Advantages in the use of a double reed type valve are the relative ease with which the response threshold point of the valve can be controlled, i.e., the point at which the valve responds to a pressure difference. Also the greater the pressure difference, the more the valve flaps or reed members will deflect to open the passageway and allow for fluid discharge, the valve opening being directly proportional to the applied pressure differential.
It will be also be apparent that other types of valve means, as, for example, a ball valve, single reed valve or a spring valve may be used in the construction of the device of the present invention.
Insertion and operation of the implant device into an eye will now be described.
As shown in FIG. 1, the device of the present invention may be implanted into and through the cornea 22 and into communication with the anterior chamber 14, the implantation preferably being made in the upper portion of the cornea just beneath the canal of Schlemm 20.
As was heretofore noted, the shank portion of the implant device is preferably provided with a tapered outside contour as shown in the Figures so as to facilitate easy insertion, either directly or through a prepared tract into the eye. When insertion of the implant device is to be in the cornea, for example, a hyperdermic needle-like instrument is preferably used to first pierce the cornea to provide a tract for receiving the device. The cornea is a desirable area of the eye for receiving the device since the inherent pliable nature of the cornea will permit the easy implantation of the device and also enhance a sealing around the shank portion of the device after it is received in the eye. Also, in piercing the cornea to provide the receiving tract for the implant device, there is substantially no tissue or fluid loss.
It will be understood that the device can be inserted directly into the cornea without the aid of a tract. Also, other areas of the eyeball may be used for implantation of the device of the present invention.
Upon implantation, the device flange portion 34 will seat on the cornea or other area of the eye receiving the device, while the barb projections 46 lock against the underside of the receiving tissue for retaining the device in the eye. Altemately, the barb projections may be spaced so as to lock within the stroma of the cornea, or mid area of the receiving tissue.
As was heretofore noted, the flange portion 34 of the implant device may be provided with a plurality of apertures 44 spaced around the periphery thereof. These flange apertures 44 may serve two functions. When the device is implanted in the cornea portion of the eye, the apertures allow the eye tears to wash and provide for the normal irrigation of the cornea area under the flange. Where the implant is in another area of the eye, as, for example, through the sclera, the flange apertures may be used to anchor the device in the eye with the aid of sutures.
Initially the pressure of the top surfaces 58 and 60 of the valve, i.e., the discharge end of the valve, which is exposed to the outside of the eye after implantation of the device, is at or about the atmospheric pressure. Normally, the pressure inside the eye globe, and more particularly in the anterior and posterior chambers thereof is understood to be between 15 and 25 millimeters (mm.) of mercury above the atmospheric pressure. With the occurrence of an abnormal intra-occular build up of pressure inside the eye and again particularly in the anterior chamber which after insertion of the device is effectively in communication with the bottom surfaces 54 and 56 of the reed members, i.e., the intake end of the valve, a point is reached, i.e., the threshold or program setting of the valve, wherein the valve will open to allow the passage of fluid from the anterior chamber through the shank bore of passageway to the outside of the eye wherein it mingles with existing eye tears and is disposed of in the normal manner. The increased intra-occular pressure built up is in this way controlled. The pressure point at which the valve may be programmed to open may, for example, be between 20 and 25 mm. of mercury.
When the pressure difference on both sides of the valve membrane, i.e., the top and bottom surfaces of the reed members, decreases to a preset level substantially equal to the aforementioned program setting, the valve closes. The rate and degree of valve opening is a function of the amount of the intra-occular pressure and consequently the pressures exerted on the bottom surfaces of the valve reed members. The valve serves to regulate the flow of fluid through the shank passageway in direct proportion to the degree of excessive intra-occular pressure built up in the eye. Since the intraoccular pressure will be changing as the valve allows for the discharge of fluid, the valve reeds will tend to substantially open and close or flutter in operation.
Since the cornea does not have blood vessels or a blood supply, by this fluttering action of the valve, the circulation of the aqueous is enhanced against the posterior part of the cornea. This is desirable since the aqueous normally provides a means of carrying nourishment to the cornea and also for the disposal of waste matter.
It should be noted that another advantage inherent in the implant device of the present invention is its minute size. A device in accordance with the invention has been constructed with an operating valve as abovedescribed and with a shank length of approxiamtely 2.5 mm., a bore diameter of approximately 0.5 mm., and a flange portion 2 mm. in diameter.
It will be appreciated that the relatively small size of the device will minimize friction between an eyelid and the device when implanted. Also, during implantation of the device and because of its size, there will be substantially no tissue of fluid loss.
Turning now to FIG. 6, there is illustrated a fragmentary sectional view showing a modified embodiment of the flange and retaining means portons of the implant device of the present invention.
More particularly, the upper end of the shank portion 28 is necked down as shown so as to provide a step or shelf 62 which functions to help retain the implant device in an eye in a manner similar to that of the heretofore described barb projections shown in FIG. 4. The top surface 40 of the flange portion 34 is provided with an integrally formed annular rib or ridge member 64. With the device implanted in an area of the eye other than the cornea, and more particularly the sclera, the ridge 64 will serve to discourage the formation of cicatrix or scar tissue over the flange opening of the passageway.
It will thus be seen that the device herein described may be easily implanted in a human eye, provides a minimum of discomfort to the recipient, and functions in a simple, eyt effective manner to control an intraoccular pressure build up. It will also be clear that variations in the details of consruction which are specifically illustrated and described may be resorted to without departing from the scope of the invention.
What is claimed is:
1. A surgical implant device for implantation in an eye comprising:
an elongated shank member generally tubular in shape and having a flange surrounding one end thereof, said shank member being provided with a passageway opening in said one end through said flange and axially extending through said shank and out the other end thereof;
valve means seated within said passageway and normally positioned to provide for closure thereof, said valve means opening in response to a predetermined pressure differential within said passageway and on opposing sides of the valve; and
means integrally formed on and disposed along said shank member axially spaced from said flange for the retention of said device in an eye; said flange being in an inclined position relative to the axis of said shank member and the side of said flange from which the shank extends being arcuately contoured to conform generally to the surface of a human eye. 2. A device as defined in claim 1 wherein said retention means includes a plurality of spaced projections formed on the outside surface of said shank member and angled upwardly toward said flange portion.
3. A device as defined in claim 1 wherein a first portion of said shank member depends from said flange portion and is necked down to form a step with the remaining portion thereof, the remaining portion of said shank member thereafter tapering toward said botton end.
4. A device as defined in claim 1 wherein said flange includes a ridge member integrally formed on the surface thereof opposite said shank and concentric with the opening therein,
5. A device as defined in claim 1 wherein said valve means includes a pair of opposing reed members integrally formed within said passageway and extending thereacross so as to normally close off said passageway. 6. A device as defined in claim 5 wherein said flange includes a plurality of openings spaced around the periphery thereof.
7. A surgical device for implantation in an eye comprising:
a flange portion having top and bottom surfaces and a central aperture therein;
an elongated body portion integral with said flange portion and depending from the bottom surface thereof, said body portion having an internal passageway continuous with said flange opening and extending lengthwise through said body portion to an axially in-line opening at the other end thereof;
pressure sensitive valve means seated within said passageway and normally positioned to provide for closure of said passageway, said valve means opening in response to a predetermined pressure differential within said passageway and on opposing sides of the valve;
said flange portion being generally circular in shape and overlying said body portion in an inclined position relative to the longitudinal axis of said body portion, said flange including a plurality of apertures spaced along the periphery thereof; and means integrally formed on and displaced along said body portion beneath said flange portion for the retention of said device in an eye, said retention means including a plurality of spaced projections formed along the outside surface of said body portion and angled upwardly toward said flange portion.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US15192 *||Jun 24, 1856|| ||Tubular|
|US274447 *||Jan 19, 1881||Mar 20, 1883|| ||William-kentish|
|US733152 *||Aug 30, 1902||Jul 7, 1903||Murdoch Chisholm||Empyema drainage device.|
|US1388172 *||Mar 18, 1920||Aug 23, 1921||Craddock Simon M||Veterinary surgical appliance|
|US2867213 *||Jun 12, 1957||Jan 6, 1959||Jr Paul A Thomas||Flutter valve for drainage of the pleural cavity|
|US3159161 *||Nov 14, 1962||Dec 1, 1964||Alton Ness Richard||Fistulizing canaliculus|
|US3333588 *||Jul 6, 1964||Aug 1, 1967||Schulte Rudolf R||Brain ventricle cannula|
|US3421509 *||Dec 17, 1965||Jan 14, 1969||John M Fiore||Urethral catheter|
|1|| *||Ellis, R. A. Reduction of Intraocular Pressure Using Plastics in Surgery , in Amer. Jour. Ophthal., 50: 733 742, 1960.|
|2|| *||Ore, Svein et al., Preparation of Surgical Implants From Silicone Rubber by Means of a Postforming Technique. Surgery, pp. 385 390, Aug. 1962.|
|3|| *||Teflon Armstrong Beveled Drain Tube, Advertisement of Richards Mfg. Co., Memphis, Tenn. Copyright 1966.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3890976 *||Jan 21, 1974||Jun 24, 1975||Medical Products Corp||Catheter tip assembly|
|US3915172 *||Mar 26, 1973||Oct 28, 1975||Ceskoslovenska Akademie Ved||Capillary drain for glaucoma|
|US3938529 *||Jul 22, 1974||Feb 17, 1976||Gibbons Robert P||Indwelling ureteral catheter|
|US4037604 *||Jan 5, 1976||Jul 26, 1977||Newkirk John B||Artifical biological drainage device|
|US4175563 *||Oct 5, 1977||Nov 27, 1979||Arenberg Irving K||Biological drainage shunt|
|US4402681 *||Sep 10, 1981||Sep 6, 1983||Haas Joseph S||Artificial implant valve for the regulation of intraocular pressure|
|US4474569 *||Jun 28, 1982||Oct 2, 1984||Denver Surgical Developments, Inc.||Antenatal shunt|
|US4521210 *||Dec 27, 1982||Jun 4, 1985||Wong Vernon G||Eye implant for relieving glaucoma, and device and method for use therewith|
|US4554918 *||Jul 28, 1982||Nov 26, 1985||White Thomas C||Ocular pressure relief device|
|US4587954 *||Jan 27, 1984||May 13, 1986||Habley Medical Technology Corporation||Elastomeric prosthetic sphincter|
|US4604087 *||Jun 21, 1985||Aug 5, 1986||Joseph Neil H||Aqueous humor drainage device|
|US4645493 *||Oct 21, 1985||Feb 24, 1987||N.U.S. S.R.L.||Catheter for medical-surgical application|
|US4722724 *||Jun 23, 1986||Feb 2, 1988||Stanley Schocket||Anterior chamber tube shunt to an encircling band, and related surgical procedure|
|US4781675 *||Aug 27, 1987||Nov 1, 1988||White Thomas C||Infusion cannula|
|US4808183 *||Jun 3, 1980||Feb 28, 1989||University Of Iowa Research Foundation||Voice button prosthesis and method for installing same|
|US4813941 *||Sep 3, 1987||Mar 21, 1989||Leslie Shea||Pneumothorax treatment device|
|US4826478 *||Aug 21, 1987||May 2, 1989||Stanley Schocket||Anterior chamber tube shunt to an encircling band, and related surgical procedure|
|US4886488 *||Aug 4, 1988||Dec 12, 1989||White Thomas C||Glaucoma drainage the lacrimal system and method|
|US4936825 *||Apr 11, 1988||Jun 26, 1990||Ungerleider Bruce A||Method for reducing intraocular pressure caused by glaucoma|
|US4968296 *||Dec 20, 1989||Nov 6, 1990||Robert Ritch||Transscleral drainage implant device for the treatment of glaucoma|
|US5064417 *||Oct 11, 1989||Nov 12, 1991||Co Pharma Corporation S.R.L.||Device for fastening a catheter to a cranial theca for performing cerebro spinal fluid drainage to the outside operations|
|US5092837 *||Aug 27, 1990||Mar 3, 1992||Robert Ritch||Method for the treatment of glaucoma|
|US5098393 *||May 31, 1988||Mar 24, 1992||Kurt Amplatz||Medical introducer and valve assembly|
|US5171213 *||Aug 14, 1991||Dec 15, 1992||Price Jr Francis W||Technique for fistulization of the eye and an eye filtration prosthesis useful therefor|
|US5178604 *||May 31, 1990||Jan 12, 1993||Iovision, Inc.||Glaucoma implant|
|US5207660 *||Apr 26, 1991||May 4, 1993||Cornell Research Foundation, Inc.||Method for the delivery of compositions to the ocular tissues|
|US5221278 *||Mar 12, 1992||Jun 22, 1993||Alza Corporation||Osmotically driven delivery device with expandable orifice for pulsatile delivery effect|
|US5318558 *||Dec 1, 1992||Jun 7, 1994||Alza Corporation||Osmotically driven delivery device with expandable orifice for pulsatile delivery effect|
|US5372577 *||Feb 18, 1993||Dec 13, 1994||Ungerleider; Bruce A.||Apparatus for reducing intraocular pressure|
|US5397300 *||Apr 21, 1994||Mar 14, 1995||Iovision, Inc.||Glaucoma implant|
|US5476445 *||Aug 1, 1994||Dec 19, 1995||Iovision, Inc.||Glaucoma implant with a temporary flow restricting seal|
|US5558629 *||Jul 21, 1992||Sep 24, 1996||Iovision, Inc.||Glaucoma implant|
|US5626558 *||May 5, 1995||May 6, 1997||Suson; John||Adjustable flow rate glaucoma shunt and method of using same|
|US5626559 *||May 1, 1995||May 6, 1997||Ramot University Authority For Applied Research And Industrial Development Ltd.||Ophthalmic device for draining excess intraocular fluid|
|US5660205 *||Dec 15, 1994||Aug 26, 1997||Epstein; Alan B.||One-way valve|
|US5702414 *||Sep 5, 1996||Dec 30, 1997||Optonol Ltd||Method of implanting an intraocular implant|
|US5769093 *||May 15, 1997||Jun 23, 1998||Xomed Surgical Products, Inc.||Method of relieving synovial fluid pressure|
|US5807303 *||May 13, 1997||Sep 15, 1998||Xomed Surgical Products, Inc.||Valve assembly and device for relieving synovial fluid pressure|
|US5968058 *||Jul 14, 1997||Oct 19, 1999||Optonol Ltd.||Device for and method of implanting an intraocular implant|
|US5971967 *||Aug 19, 1997||Oct 26, 1999||Abbeymoor Medical, Inc.||Urethral device with anchoring system|
|US6004302 *||Aug 28, 1997||Dec 21, 1999||Brierley; Lawrence A.||Cannula|
|US6050970 *||May 8, 1997||Apr 18, 2000||Pharmacia & Upjohn Company||Method and apparatus for inserting a glaucoma implant in an anterior and posterior segment of the eye|
|US6203513||Nov 20, 1997||Mar 20, 2001||Optonol Ltd.||Flow regulating implant, method of manufacture, and delivery device|
|US6221060||Oct 4, 1999||Apr 24, 2001||Abbeymoor Medical, Inc.||Urethral device with anchoring system|
|US6258060||Jun 30, 1999||Jul 10, 2001||Abbeymoon Medical, Inc.||Urethral apparatus with position indicator and methods of use thereof|
|US6293951 *||Aug 24, 1999||Sep 25, 2001||Spiration, Inc.||Lung reduction device, system, and method|
|US6450984||Apr 26, 2000||Sep 17, 2002||Gmp Vision Solutions, Inc.||Shunt device and method for treating glaucoma|
|US6464724||Apr 26, 2000||Oct 15, 2002||Gmp Vision Solutions, Inc.||Stent device and method for treating glaucoma|
|US6468283 *||Aug 26, 1999||Oct 22, 2002||Optonol, Ltd.||Method of regulating pressure with an intraocular implant|
|US6508779||Jan 24, 1997||Jan 21, 2003||John Suson||Adjustable flow rate glaucoma shunt and method of using same|
|US6510600||Dec 4, 2000||Jan 28, 2003||Optonol, Ltd.||Method for manufacturing a flow regulating implant|
|US6544249||Nov 28, 1997||Apr 8, 2003||The Lions Eye Institute Of Western Australia Incorporated||Biological microfistula tube and implantation method and apparatus|
|US6558342||Jun 2, 1999||May 6, 2003||Optonol Ltd.||Flow control device, introducer and method of implanting|
|US6595945 *||Jan 9, 2001||Jul 22, 2003||J. David Brown||Glaucoma treatment device and method|
|US6626858||Sep 12, 2002||Sep 30, 2003||Gmp Vision Solutions, Inc.||Shunt device and method for treating glaucoma|
|US6632243||Sep 16, 1999||Oct 14, 2003||Emphasys Medical Inc.||Body fluid flow control device|
|US6666841||May 2, 2001||Dec 23, 2003||Glaukos Corporation||Bifurcatable trabecular shunt for glaucoma treatment|
|US6679264||Mar 4, 2000||Jan 20, 2004||Emphasys Medical, Inc.||Methods and devices for use in performing pulmonary procedures|
|US6692455||Dec 28, 2001||Feb 17, 2004||Medtronic Xomed, Inc.||Composite ventilation tube|
|US6694979||Mar 2, 2001||Feb 24, 2004||Emphasys Medical, Inc.||Methods and devices for use in performing pulmonary procedures|
|US6726664||Aug 6, 2001||Apr 27, 2004||Optonol Ltd.||Flow control device, introducer and method of implanting|
|US6730056 *||Sep 21, 2000||May 4, 2004||Motorola, Inc.||Eye implant for treating glaucoma and method for manufacturing same|
|US6736791||Nov 1, 2000||May 18, 2004||Glaukos Corporation||Glaucoma treatment device|
|US6780164||Mar 21, 2003||Aug 24, 2004||Glaukos Corporation||L-shaped implant with bi-directional flow|
|US6783544||Oct 11, 2002||Aug 31, 2004||Gmp Vision Solutions, Inc.||Stent device and method for treating glaucoma|
|US6827699||May 27, 2003||Dec 7, 2004||Gmp Vision Solutions, Inc.||Shunt device and method for treating glaucoma|
|US6827700||May 27, 2003||Dec 7, 2004||Gmp Vision Solutions, Inc.||Shunt device and method for treating glaucoma|
|US6840243 *||Apr 18, 2003||Jan 11, 2005||Emphasys Medical, Inc.||Methods and devices for use in performing pulmonary procedures|
|US6881198||Jun 16, 2003||Apr 19, 2005||J. David Brown||Glaucoma treatment device and method|
|US6901927||Nov 22, 2002||Jun 7, 2005||Emphasys Medical, Inc.||Methods and devices for use in performing pulmonary procedures|
|US6904909||Nov 22, 2002||Jun 14, 2005||Emphasys Medical, Inc.||Methods and devices for use in performing pulmonary procedures|
|US6929637||Dec 11, 2002||Aug 16, 2005||Spiration, Inc.||Device and method for intra-bronchial provision of a therapeutic agent|
|US6936023||Oct 10, 2003||Aug 30, 2005||Medtronic Xomed, Inc.||Composite ventilation tube|
|US6939494||Dec 28, 2001||Sep 6, 2005||Medtronic Xomed, Inc.||Method of making ventilation tube|
|US6941950||Oct 10, 2002||Sep 13, 2005||Emphasys Medical, Inc.||Bronchial flow control devices and methods of use|
|US6955656||Dec 4, 2002||Oct 18, 2005||Glaukos Corporation||Apparatus and method for treating glaucoma|
|US6966888 *||Jan 13, 2002||Nov 22, 2005||Eagle Vision, Inc.||Sinus valved glaucoma shunt|
|US6981958||Jul 24, 2003||Jan 3, 2006||Glaukos Corporation||Implant with pressure sensor for glaucoma treatment|
|US7011094||Jul 25, 2003||Mar 14, 2006||Emphasys Medical, Inc.||Bronchial flow control devices and methods of use|
|US7033387||Apr 18, 2003||Apr 25, 2006||Emphasys Medical, Inc.||Body fluid flow control device|
|US7094225||May 3, 2002||Aug 22, 2006||Glaukos Corporation||Medical device and methods of use of glaucoma treatment|
|US7100616||Apr 8, 2003||Sep 5, 2006||Spiration, Inc.||Bronchoscopic lung volume reduction method|
|US7135009||Apr 8, 2002||Nov 14, 2006||Glaukos Corporation||Glaucoma stent and methods thereof for glaucoma treatment|
|US7163543||Jun 7, 2002||Jan 16, 2007||Glaukos Corporation||Combined treatment for cataract and glaucoma treatment|
|US7165548||Jul 29, 2003||Jan 23, 2007||Emphasys Medical, Inc.||Methods and devices for use in performing pulmonary procedures|
|US7186232||Mar 7, 2003||Mar 6, 2007||Glaukoa Corporation||Fluid infusion methods for glaucoma treatment|
|US7195646 *||Oct 28, 2002||Mar 27, 2007||Oded Nahleili||Polymeric stent useful for the treatment of the salivary gland ducts and method for using the same|
|US7220238 *||Jul 27, 2004||May 22, 2007||Gmp Vision Solutions, Inc.||Shunt device and method for treating glaucoma|
|US7226540||Aug 4, 2004||Jun 5, 2007||Becton, Dickinson And Company||MEMS filter module|
|US7273475||Oct 21, 2005||Sep 25, 2007||Glaukos Corporation||Medical device and methods of use for glaucoma treatment|
|US7276077||Jun 3, 2003||Oct 2, 2007||Emphasys Medical, Inc.||Body fluid flow control device|
|US7291125||Nov 14, 2003||Nov 6, 2007||Transcend Medical, Inc.||Ocular pressure regulation|
|US7297130||Mar 21, 2003||Nov 20, 2007||Glaukos Corporation||Implant with anchor|
|US7331984||Aug 28, 2002||Feb 19, 2008||Glaukos Corporation||Glaucoma stent for treating glaucoma and methods of use|
|US7354416 *||Feb 18, 2004||Apr 8, 2008||Hugo Quiroz-Mercado||Methods and devices for draining fluids and lowering intraocular pressure|
|US7364564||Dec 24, 2004||Apr 29, 2008||Becton, Dickinson And Company||Implant having MEMS flow module with movable, flow-controlling baffle|
|US7384550||Feb 24, 2005||Jun 10, 2008||Becton, Dickinson And Company||Glaucoma implant having MEMS filter module|
|US7412977||Mar 6, 2003||Aug 19, 2008||Emphasys Medical, Inc.||Methods and devices for inducing collapse in lung regions fed by collateral pathways|
|US7431710||Mar 18, 2005||Oct 7, 2008||Glaukos Corporation||Ocular implants with anchors and methods thereof|
|US7434578||Dec 22, 2003||Oct 14, 2008||Spiration, Inc.||Methods of achieving lung volume reduction with removable anchored devices|
|US7476203||Oct 26, 2005||Jan 13, 2009||Spiration, Inc.||Device and method for measuring the diameter of an air passageway|
|US7481816 *||Oct 27, 2003||Jan 27, 2009||Optonol Ltd.||Intraocular implant, delivery device, and method of implantation|
|US7488303||Sep 22, 2003||Feb 10, 2009||Glaukos Corporation||Ocular implant with anchor and multiple openings|
|US7507258||Mar 5, 2007||Mar 24, 2009||Oded Nahleili||Polymeric stent useful for the treatment of the salivary gland ducts and method for using the same|
|US7533671||Dec 22, 2003||May 19, 2009||Spiration, Inc.||Bronchoscopic repair of air leaks in a lung|
|US7544176||Jun 21, 2005||Jun 9, 2009||Becton, Dickinson And Company||Glaucoma implant having MEMS flow module with flexing diaphragm for pressure regulation|
|US7563241||Nov 13, 2006||Jul 21, 2009||Glaukos Corporation||Implant and methods thereof for treatment of ocular disorders|
|US7662181||Mar 30, 2006||Feb 16, 2010||Pulmonx Corporation||Methods and devices for use in performing pulmonary procedures|
|US7670310||Dec 7, 2007||Mar 2, 2010||Optonol Ltd||Flow regulating implants|
|US7670373||Mar 3, 1998||Mar 2, 2010||Pulmonx Corporation||Occlusion device|
|US7678065||Sep 24, 2004||Mar 16, 2010||Glaukos Corporation||Implant with intraocular pressure sensor for glaucoma treatment|
|US7708711||Nov 12, 2003||May 4, 2010||Glaukos Corporation||Ocular implant with therapeutic agents and methods thereof|
|US7717115||Nov 25, 2003||May 18, 2010||Pulmonx Corporation||Delivery methods and devices for implantable bronchial isolation devices|
|US7757692||Apr 22, 2009||Jul 20, 2010||Spiration, Inc.||Removable lung reduction devices, systems, and methods|
|US7771472||Nov 18, 2005||Aug 10, 2010||Pulmonx Corporation||Bronchial flow control devices and methods of use|
|US7798147||Jul 25, 2003||Sep 21, 2010||Pulmonx Corporation||Bronchial flow control devices with membrane seal|
|US7814912||Jun 29, 2005||Oct 19, 2010||Pulmonx Corporation||Delivery methods and devices for implantable bronchial isolation devices|
|US7815592||Apr 22, 2008||Oct 19, 2010||Transcend Medical, Inc.||Ocular pressure regulation|
|US7842061||Dec 23, 2003||Nov 30, 2010||Spiration, Inc.||Methods of achieving lung volume reduction with removable anchored devices|
|US7850637 *||Nov 12, 2004||Dec 14, 2010||Glaukos Corporation||Shunt device and method for treating glaucoma|
|US7850638||Dec 22, 2006||Dec 14, 2010||Transcend Medical, Inc.||Ocular pressure regulation|
|US7854228||Mar 28, 2005||Dec 21, 2010||Pulmonx Corporation||Bronchial flow control devices and methods of use|
|US7857782||Feb 5, 2009||Dec 28, 2010||Glaukos Corporation||Ocular implant delivery system and method thereof|
|US7862531||Jun 25, 2004||Jan 4, 2011||Optonol Ltd.||Flow regulating implants|
|US7867186||Aug 5, 2003||Jan 11, 2011||Glaukos Corporation||Devices and methods for treatment of ocular disorders|
|US7867205||May 6, 2005||Jan 11, 2011||Glaukos Corporation||Method of delivering an implant for treating an ocular disorder|
|US7875048||Sep 3, 2004||Jan 25, 2011||Spiration, Inc.||One-way valve devices for anchored implantation in a lung|
|US7879001||Aug 8, 2007||Feb 1, 2011||Glaukos Corporation||Devices and methods for treatment of ocular disorders|
|US7879079||Jun 19, 2006||Feb 1, 2011||Glaukos Corporation||Implant delivery system and methods thereof for treating ocular disorders|
|US7887585||Mar 4, 2009||Feb 15, 2011||Spiration, Inc.||Bronchoscopic repair of air leaks in a lung|
|US7896887||Apr 10, 2007||Mar 1, 2011||Spiration, Inc.||Apparatus and method for deployment of a bronchial obstruction device|
|US7942931||Aug 15, 2005||May 17, 2011||Spiration, Inc.||Device and method for intra-bronchial provision of a therapeutic agent|
|US7947008||Aug 12, 2008||May 24, 2011||University Of Saskatchewan||Shunt and method treatment of glaucoma|
|US7951121 *||Jul 30, 2003||May 31, 2011||Navilyst Medical, Inc.||Pressure actuated valve with improved slit configuration|
|US7951155||Jan 16, 2007||May 31, 2011||Glaukos Corporation||Combined treatment for cataract and glaucoma treatment|
|US8007459||Dec 18, 2008||Aug 30, 2011||Glaukos Corporation||Ocular implant with anchoring mechanism and multiple outlets|
|US8012115||Apr 7, 2008||Sep 6, 2011||S.K. Pharmaceuticals, Inc.||Optic nerve implants|
|US8021385||Jul 19, 2007||Sep 20, 2011||Spiration, Inc.||Removable anchored lung volume reduction devices and methods|
|US8034016||Dec 7, 2007||Oct 11, 2011||Optonol, Ltd.||Flow regulating implants and methods of implanting|
|US8043301||Apr 10, 2009||Oct 25, 2011||Spiration, Inc.||Valve loader method, system, and apparatus|
|US8062244||Feb 5, 2009||Nov 22, 2011||Glaukos Corporation||Self-trephining implant and methods thereof for treatment of ocular disorders|
|US8075511||Apr 28, 2008||Dec 13, 2011||Glaukos Corporation||System for treating ocular disorders and methods thereof|
|US8079368||Mar 10, 2010||Dec 20, 2011||Spiration, Inc.||Bronchoscopic lung volume reduction method|
|US8109896||Feb 11, 2008||Feb 7, 2012||Optonol Ltd.||Devices and methods for opening fluid passageways|
|US8118768||Oct 6, 2008||Feb 21, 2012||Dose Medical Corporation||Drug eluting ocular implant with anchor and methods thereof|
|US8128588 *||Dec 22, 2006||Mar 6, 2012||Transcend Medical, Inc.||Ocular pressure regulation|
|US8136230||Oct 10, 2008||Mar 20, 2012||Spiration, Inc.||Valve loader method, system, and apparatus|
|US8136520||Jan 14, 2010||Mar 20, 2012||Pulmonx Corporation||Occlusion device|
|US8142364||Jan 4, 2010||Mar 27, 2012||Dose Medical Corporation||Method of monitoring intraocular pressure and treating an ocular disorder|
|US8152752||Nov 12, 2004||Apr 10, 2012||Glaukos Corporation||Shunt device and method for treating glaucoma|
|US8167939||Sep 26, 2011||May 1, 2012||Transcend Medical, Inc.||Ocular implant with stiffness qualities, methods of implantation and system|
|US8172899||Sep 26, 2011||May 8, 2012||Transcend Medical, Inc.||Ocular implant with stiffness qualities, methods of implantation and system|
|US8177805||Aug 4, 2011||May 15, 2012||Spiration, Inc.||Removable anchored lung volume reduction devices and methods|
|US8187234||Jan 29, 2004||May 29, 2012||Navilyst Medical, Inc.||Pressure activated safety valve with anti-adherent coating|
|US8206684||Feb 25, 2005||Jun 26, 2012||Pulmonx Corporation||Methods and devices for blocking flow through collateral pathways in the lung|
|US8246569 *||Aug 16, 2005||Aug 21, 2012||California Institute Of Technology||Implantable intraocular pressure drain|
|US8251067||Aug 16, 2010||Aug 28, 2012||Pulmonx Corporation||Bronchial flow control devices with membrane seal|
|US8257321||May 21, 2008||Sep 4, 2012||Navilyst Medical, Inc.||Pressure activated valve for high flow rate and pressure venous access applications|
|US8257381||Dec 15, 2010||Sep 4, 2012||Spiration, Inc.||One-way valve devices for anchored implantation in a lung|
|US8262726||Oct 5, 2010||Sep 11, 2012||Transcend Medical, Inc.||Ocular implant with stiffness qualities, methods of implantation and system|
|US8267882||Mar 5, 2009||Sep 18, 2012||Ivantis, Inc.||Methods and apparatus for treating glaucoma|
|US8273050||Jul 12, 2004||Sep 25, 2012||Glaukos Corporation||Ocular implant with anchor and therapeutic agent|
|US8277418||Nov 22, 2010||Oct 2, 2012||Alcon Research, Ltd.||Ophthalmic valved trocar cannula|
|US8282592||May 6, 2010||Oct 9, 2012||Ivantis, Inc.||Glaucoma treatment method|
|US8308701||Nov 15, 2010||Nov 13, 2012||Aquesys, Inc.||Methods for deploying intraocular shunts|
|US8313454 *||Mar 26, 2010||Nov 20, 2012||Optonol Ltd.||Fluid drainage device, delivery device, and associated methods of use and manufacture|
|US8328768||Feb 11, 2005||Dec 11, 2012||Angiodynamics, Inc||Pressure activated safety valve with improved flow characteristics and durability|
|US8333742||May 7, 2009||Dec 18, 2012||Glaukos Corporation||Method of delivering an implant for treating an ocular disorder|
|US8337445||Sep 25, 2007||Dec 25, 2012||Glaukos Corporation||Ocular implant with double anchor mechanism|
|US8337470||Jan 28, 2009||Dec 25, 2012||Angiodynamics, Inc.||Three-way valve for power injection in vascular access devices|
|US8343106||Nov 22, 2010||Jan 1, 2013||Alcon Research, Ltd.||Ophthalmic valved trocar vent|
|US8348877||May 3, 2010||Jan 8, 2013||Dose Medical Corporation||Ocular implant with therapeutic agents and methods thereof|
|US8353856||Nov 5, 2008||Jan 15, 2013||Abbott Medical Optics Inc.||Glaucoma drainage shunts and methods of use|
|US8357139||Nov 4, 2008||Jan 22, 2013||Pulmonx Corporation||Methods and devices for use in performing pulmonary procedures|
|US8372026||Feb 3, 2012||Feb 12, 2013||Ivantis, Inc.||Ocular implant architectures|
|US8377011||Aug 31, 2011||Feb 19, 2013||Angiodynamics, Inc.||Pressure activated valve with high flow slit|
|US8377122||Jan 27, 2010||Feb 19, 2013||Transcend Medical, Inc.||Ocular implant with stiffness qualities, methods of implantation and system|
|US8382664 *||Oct 27, 2011||Feb 26, 2013||Applied Medical Technology, Inc.||Molded and undivided medical penetrating device|
|US8388568||May 7, 2009||Mar 5, 2013||Glaukos Corporation||Shunt device and method for treating ocular disorders|
|US8388682||Jun 22, 2010||Mar 5, 2013||Pulmonx Corporation||Bronchial flow control devices and methods of use|
|US8414518||Mar 21, 2012||Apr 9, 2013||Ivantis, Inc.||Glaucoma treatment method|
|US8414655||Jul 1, 2010||Apr 9, 2013||Spiration, Inc.||Removable lung reduction devices, systems, and methods|
|US8425449||Jul 9, 2010||Apr 23, 2013||Ivantis, Inc.||Ocular implants and methods for delivering ocular implants into the eye|
|US8444588||Feb 23, 2010||May 21, 2013||Transcend Medical, Inc.||Internal shunt and method for treating glaucoma|
|US8444690||Jan 12, 2011||May 21, 2013||Spiration, Inc.||Bronchoscopic repair of air leaks in a lung|
|US8454574||Apr 30, 2012||Jun 4, 2013||Navilyst Medical, Inc.||Pressure activated safety valve with grooved membrane|
|US8454708||Apr 5, 2010||Jun 4, 2013||Spiration, Inc.||Articulable anchor|
|US8474460||Sep 17, 2010||Jul 2, 2013||Pulmonx Corporation||Implanted bronchial isolation devices and methods|
|US8486000 *||Nov 12, 2004||Jul 16, 2013||Transcend Medical, Inc.||Ocular pressure regulation|
|US8486086||Nov 7, 2011||Jul 16, 2013||Optonol, Ltd||Flow regulating implant, method of manufacture, and delivery device|
|US8506515 *||Nov 9, 2007||Aug 13, 2013||Glaukos Corporation||Uveoscleral shunt and methods for implanting same|
|US8512404||Nov 20, 2007||Aug 20, 2013||Ivantis, Inc.||Ocular implant delivery system and method|
|US8523821||Nov 23, 2011||Sep 3, 2013||Navilyst Medical, Inc||Power injection valve|
|US8529492||Dec 20, 2010||Sep 10, 2013||Trascend Medical, Inc.||Drug delivery devices and methods|
|US8529494||Sep 11, 2012||Sep 10, 2013||Ivantis, Inc.||Methods and apparatus for treating glaucoma|
|US8529523||Oct 14, 2008||Sep 10, 2013||Navilyst Medical, Inc.||Pressure actuated valve with improved biasing member|
|US8540685||Nov 16, 2011||Sep 24, 2013||Navilyst Medical, Inc.||Valved catheters including high flow rate catheters|
|US8551166||Nov 19, 2012||Oct 8, 2013||Ivantis, Inc.||Methods and apparatus for delivering ocular implants into the eye|
|US8574294||Dec 16, 2010||Nov 5, 2013||Transcend Medical, Inc.||Ocular implant with stiffness qualities, methods of implantation and system|
|US8579846||Nov 21, 2011||Nov 12, 2013||Glaukos Corporation||Ocular implant systems|
|US8585629||Dec 8, 2011||Nov 19, 2013||Aquesys, Inc.||Systems for deploying intraocular shunts|
|US8585630 *||Jul 23, 2012||Nov 19, 2013||California Institute Of Technology||Implantable intraocular pressure drain|
|US8585660||Jan 25, 2006||Nov 19, 2013||Navilyst Medical, Inc.||Valved catheter with power injection bypass|
|US8617094||Jan 12, 2006||Dec 31, 2013||Glaukos Corporation||Fluid infusion methods for glaucoma treatment|
|US8617139||Jun 25, 2009||Dec 31, 2013||Transcend Medical, Inc.||Ocular implant with shape change capabilities|
|US20100174272 *||Dec 18, 2009||Jul 8, 2010||Weiner Alan L||In-situ refillable ophthalmic implant|
|US20100274259 *||Mar 26, 2010||Oct 28, 2010||Optonol Ltd.||Fluid drainage device, delivery device, and associated methods of use and manufacture|
|US20110196281 *||Dec 13, 2010||Aug 11, 2011||Glaukos Corporation||Shunt device and method for treating ocular disorders|
|US20110282456 *||Feb 5, 2010||Nov 17, 2011||Newvert Ltd.||Implantable device for sealing a spinal annular fissure tear and method for deploying the same|
|US20120041270 *||Oct 27, 2011||Feb 16, 2012||Applied Medical Technology, Inc.||Molded and undivided medical penetrating device|
|EP0102747A1 *||Jul 28, 1983||Mar 14, 1984||Thomas C. White||Ocular pressure relief device|
|EP0228185A1 *||Nov 26, 1986||Jul 8, 1987||Thomas C. White||Tissue-implantable fluid-dissipating device|
|EP0967946A1 *||Nov 28, 1997||Jan 5, 2000||The Lions Eye Institute of Western Australia Incorporated||Biological microfistula tube and implantation method and apparatus|
|EP1184010A2 *||Aug 29, 2001||Mar 6, 2002||Aixmed Gesellschaft für Medizintechnik mbH||Aqueous humour drainage device|
|EP1418868A2 *||Apr 8, 2002||May 19, 2004||Glaukos Corporation||Glaucoma stent and methods thereof for glaucoma treatment|
|EP1473004A2||May 13, 1996||Nov 3, 2004||Optonol Ltd.||Ophtalmic implant for treating glaucoma and delivery device|
|EP1477146A2 *||Apr 26, 2000||Nov 17, 2004||Gmp Vision Solutions, Inc.||Shunt device and method for treating glaucoma|
|EP1596902A2 *||Feb 18, 2004||Nov 23, 2005||Hampar Karageozian||Methods and devices for draining fluids and lowering intraocular pressure|
|EP2319469A1||Nov 18, 1998||May 11, 2011||Optonol Ltd.||Flow regulating implant, method of manufacturing, and delivery device|
|WO1989000869A1 *||Aug 8, 1988||Feb 9, 1989||Thomas C White||Glaucoma drainage in the lacrimal system|
|WO1993003778A1 *||Aug 14, 1992||Mar 4, 1993||Francis W Price Jr||Eye filtration prosthesis for relieving intraocular pressure|
|WO1996018357A2 *||Dec 7, 1995||Jun 20, 1996||F Barry Bays||Valve assembly and method for relieving synovial fluid pressure|
|WO1999008741A1 *||Aug 19, 1998||Feb 25, 1999||Abbeymoor Medical Inc||Urethral device with anchoring system|
|WO2000064391A1 *||Apr 26, 2000||Nov 2, 2000||Reay H Brown||Stent device and method for treating glaucoma|
|WO2000064393A1 *||Apr 26, 2000||Nov 2, 2000||Reay H Brown||Shunt device and method for treating glaucoma|
|WO2002070045A1 *||Jan 9, 2002||Sep 12, 2002||J David Brown||Glaucoma treatment device and method|
|WO2002080811A2 *||Apr 8, 2002||Oct 17, 2002||Glaukos Corp||Glaucoma stent and methods thereof for glaucoma treatment|
|WO2004062469A2 *||Jan 5, 2004||Jul 29, 2004||Clarity Corp||Sinus valved glaucoma shunt|
|WO2005016418A1 *||Aug 3, 2004||Feb 24, 2005||Glaukos Corp||Devices and methods for glaucoma treatment|
|WO2005046782A1 *||Nov 12, 2004||May 26, 2005||Minas Theodore Coroneo||Ocular pressure regulation|
|WO2005122980A1 *||Jun 10, 2005||Dec 29, 2005||Savage James||Apparatus and method for non-pharmacological treatment of glaucoma and lowering intraocular pressure|
|WO2010126076A1 *||Apr 28, 2010||Nov 4, 2010||Mani,Inc.||Cannula for ophthalmic surgery and method of manufacturing same|