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Publication numberUS3789029 A
Publication typeGrant
Publication dateJan 29, 1974
Filing dateOct 4, 1971
Priority dateJul 6, 1970
Publication numberUS 3789029 A, US 3789029A, US-A-3789029, US3789029 A, US3789029A
InventorsM Hodosh
Original AssigneeResearch Corp
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Plastic bone composition and method of making same
US 3789029 A
Abstract  available in
Images(3)
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Claims  available in
Description  (OCR text may contain errors)

"United States Patent 3,789,029 PLASTIC BONE COMPOSITION AND METHOD OF MAKING SAME Milton Hodosh, Providence, R.I., assignor to Research Corporation, New York, NY.

No Drawing. Continuation-impart of application Ser. No. 60,983, July 6, 1970, which is a division of application Ser. No. 805,400, Mar. 10, 1969, now Patent No. 3,609,867. This application Oct. 4, 1971, Ser. No.

Int. Cl. C081? 47/10, 45/04 US. Cl. 260-25 R 6 Claims ABSTRACT OF THE DISCLOSURE A plastic bone composition and method of making same, said composition comprising as its basic ingredients a mixture of an acrylic polymer, a foaming agent, N- tributyl phosphate, and grated anorganic bone. The mixture is usable for dental implants, as well as for implants in other parts of the body, and as a coating for metals which may be implanted in the human body for dental purposes, orthopedic prostheses, neurosurgery, etc.

BACKGROUND OF THE INVENTION This is a continuation-in-part of applicants copending US. application Ser. No. 60,983, filed July 6, 1970, which in turn is a division of applicants copending application Ser. No. 805,400, filed Mar. 10, 1969, now Pat. No. 3,609,867.

It is well known in the dental art to utilize an acrylic polymer, such as polymethacrylate, for example, in the making of denture bases; and, also, artificial implants have heretofore been made of this material. These acrylic polymers have many characteristics that make them highly desirable for use as an artificial implant, which characteristics include the fact that this plastic material approaches a natural tooth in hardness and rigidity, is not adversely aifected by the temperature conditions normally encountered in the human mouth can be worked with facility to any desired shape, retains its color and composition, etc. Perhaps of even greater importance is the fact that it has been found that when an acrylic polymer is used for an artificial tooth replica implant a periodontal membrane forms around the base of the artificial implant much like that which exists around a natural tooth. This periodontal membrane is the structure that acts as a shock absorber, infection limiting mechanism and as a cellular reservoir, and the presence of such a membrane in an artificial implant is extremely important and desirable. It has been found that the membrane which forms about the acrylic polymer artificial implant distributes the forces exerted to the supporting tissues of the tooth in a near-natural manner.

One of the problems that has existed in connection with acrylic polymer dental implants is the fact that the fibrous interlock between the artificial implant and its periodontal membrane is not as deep and penetrating as that which exists with a natural tooth, nor is the pattern of interlock the same. The instant invention overcomes this deficiency and achieves a more eifective interlock by more closely approaching the interlock which exists with a natural tooth, thus forming a more healthy periodontal membrane and a more firm and secure mounting of the artificial implant in the alveolar socket.

The instant invention also has utility in overcoming certain disadvantages that exist where metal implants are used in the human body. Metal implants have traditionally been used for dental purposes, as well as in the field of orthopedics and neurosurgery, and one of the problems that exist in such metal implants is the fact that metals have corrosive actions in the presence of living tissues, resulting in electrolytic currents. being emitted, which in turn results in resorptive and destructive phenomena. It is, therefore, desirable to coat such metallic implants with the plastic bone composition of the instant invention since, once so coated, the implant is resistant to corrosion and hence is non-conductive of the aforesaid electrolytic currents. In addition, the plastic bone coating results in a better fibrous interlock between the metallic implant and the surrounding bone in a biologically acceptable manner.

SUMMARY OF THE INVENTION It is therefore a primary object of the instant invention to provide a composition of matter for use as an implant in the human body wherein the implant is biologically accepted by the surrounding tissues and interlocks therewith in a firm manner.

A further object is the provision of a composition which may be used in the formation of an artificial dental implant, said composition being such that when the artificial implant is mounted in an alveolar socket, a periodontal-like membrane will form about the roots of the implant much like the membrane which exists around the roots of a natural tooth.

Another object is the provision of a plastic bone composition that may be used as a coating for metal implants.

Still another object is the provision of a plastic bone composition that is structurally strong but yet has sufficient porosity to enable implants or inserts of said composition in the human body to effectively interlock with surrounding bone and other tissues such as connective tissues.

DESCRIPTION OF THE INVENTION In applicants copending applications Ser. Nos. 60,983 and 805,400, a plastic bone composition is described comprising as its basic ingredients a mixture of an acrylic polymer and anorganic bone. The bone is grated or ground to powder form and then mixed with the polymer, which may be either a heat process or quick-setting plastic. Any suita'ble bone may be used, although in practice it has been found that Boplant (registered trademade of Squibb) and Kiel Bone (trademark of Unilab Surgicals) have proven to be highly satisfactory. Boplant and Kiel Bone are sterile, processed, bovine bone or cartilege commonly used for grafting procedures in orthopedic and reconstructive surgery. The plastic may be polymethacrylate, polymethylmethacrylate, or any other acrylic polymer having substantially the same characteristies.

The acrylic polymer in the above mixture imparts rigidity and strength to the composition, wherein its architectural shape is maintained; and, as previously men tioned, acrylic polymers, such as polymethacrylate, have substantially the strength, color, stability, and temperature characteristics exhibited by natural teeth, which, of course, is of extreme importance when the instant composition is used as an artificial dental implant. On the other hand, the anorganic bone in the mixture is degrading and resorptive, thus increasing the porosity of the composition. Thus, the composition becomes more porous as resorption of the bone takes place.

It has now been found-and this is really the basic concept of the present invention-that increased porosity near the outer surface of the polymer implant, where such porosity is most beneficial, may be achieved by adding to the polymer mixture a measured amount of N-tributyl phosphate. As stated, the addition of this chemical has been found to cause the resultant implantable polymer to have an increased porosity at its outer surface, said increased porosity being produced by the breakdown of one wall of each vacuole, thereby producing a surface network of interconnecting pores. This phenomenon occurs when the total mixture is polymerized as by being invested in a mold, such as a plaster mold, and heated at approximately 300 F. for approximately 30 minutes. After removal from the mold, the resultant processed polymer has an outer skin thereover, which must be removed before the polymer is implanted. The removal of this skin or film, which may be effected by any suitable procedures, such as sandblasting with quartz, changes the surface texture of the molded polymer by opening the pores located adjacent to the surface to the surrounding environment, and when implanted, to the contacting tis sues, whereby the tissues penetrate the pores to effect a secure fibrous interlock between the implant and the surrounding periodontal membrane.

The preferred composition of the present invention comprises initially a mixture of an acrylic, such as polymethacrylate, grated anorganic bone, and a foaming agent, such as dinitrosopentamethelene tetramine. Specifically, the mixture of these ingredients involves by weight approximately 65 to 70 percent of polymethacrylate, approximately 10 to 15 percent of the foaming agent, and 20 percent of the grated anorganic bone. To this mixture is added approximately 40 to 70 percent by weight of a monomer, and then approximately 20 to 100 percent by weight of the N-tributyl phosphate. When the total mixture is invested in a plaster mold or the like and heated at approximately 300 F. for 30 minutes, it will be understood that the monomer will cause polymerization of the mixture but will substantially evaporate so as not to appreciably affect the proportionate weights 'of the ingredients. The N-tributyl phosphate will also evaporate off to some undetermined degree; but it has been found that the resultant polymerized material may comprise by weight somewhere between 333 /3 and 5 8% percent acrylic polymer, 5 to 12 /2 percent foaming agent, to 16% to 50 percent N-tributyl phosphate.

As stated in my copending applications, the foaming agent adds to the porosity of the composition, and it has now been found that the foaming agent additionally appears to coact with the N-tributyl phosphate to enhance and promote the desired surface porosity. Thus it is highly desirable to use such an agent, in the proportions above set forth.

It will be understood that the real novelty in the present invention is the introduction of the N-tributyl phosphate into the mixture whereby increased porosity exists in the polymerized composition near the outer surface thereof, said porosity being subsequently exposed by removal of the outer skin from the molded composition, such as by sandblasting, after the composition has been polymerized in a mold and removed therefrom. Obviously, the degree of porosity will be dependent upon the amount of N-tributyl phosphate that is added to the mixture, as well as the amounts of foaming agent and anorganic bone, it being desirable to add a sufiicient amount of these ingredients to create the desired porosity, while at the same time not so much as to structurally weaken the material so that it will not effectively function for its intended purpose. In this connection, it has been found that the addition of anywhere between .2 and one milliliter of N-tributyl phosphate for each gram mixture of polymethylmethacrylate, foaming agent, and anorganic bone in the aforesaid proportions has provided clinically satisfactory results.

When the aforesaid compositions are used as an artificial dental implant, the tooth replica implant, after being molded and sandblasted as aforedescribed, is placed in the existing alveolar socket as soon after extraction of the natural tooth as possible. As previously stated, an artificial dental implant constructed of this composition has the highly desirable feature of forming a periodontal-like membrane much like that which exists with an actual tooth. The increased porosity adjacent the outer surface of the implant resulting from the N-tributyl phosphate causes a firm and natural-like interlock between the implant andthe periodontal membrane, since the increased porosity permits penetration of surrounding fibrous tissue into the implant. It should be noted, however, that this composition is not limited to use as a dental implant, but rather may be used as a substitute for human tissue wherever necessary and desirable, such as to fill defects or holes in the brain, skull or the like. Expressed difierently, my composition may be used as a replacement for depleted bone throughout the body, such as in cranioplastics and cysts. In addition, this composition is highly desirable for use as a coating material for metals that are used throughout the body for orthopedic prosthesis or which may be used for abutment supports for dental replacements. In other words, the composition of the present invention may be used as an implantable coating for metals and, when so used, results in increased tissue attachment to the implant for the reasons hereinabove described. By utilizing such a coating, the corrosive effects of metal are greatly diminished or eliminated, and heat transfer from the metal to the surrounding contacting tissues is greatly lessened.

The following is a specific example of a formulation from which an artificial dental implant was actually made. Two tenths of a gram of grated anorganic bone (Kiel Bone) was mixed with .15 gram of dinitrosopentamethelene tetramine and with .65 gram of polymethacrylate. To this powderous mixturue was added .5 milliliter of a monomer and .2 milliliter of N-tributyl phosphate. The entire mixture was mixed well until it assumed agenerally homogeneous gel-like consistency and then was placed in a plaster mold, the cavity of which conformed to the shape of the natural tooth being replaced, the inside of the mold first being coated with an alginate separating medium. The mold was then heated at 300 F. for 30 minutes, after which the now-polymerized composition was removed from the mold and chilled in water. The outer surface of the molded implant was then sandblasted with fine quartz to remove the outer skin therefrom. The resultant implant was characterized by a look and feel closely simulating that of a natural tooth. The implant was implanted into the jaws of a Papio baboon. The implant became firm within a two-to-three month period, and fixation to adjacent natural teeth or to other implants was no longer necessary, and the implant became completely self-supporting.

As this invention may be embodied in several forms without departing from the spirit or essential characteristics thereof, the present embodiment is therefore illustrative and not restrictive, since the scope of the invention is defined by the appended claims rather than by the description preceding them, and all changes that fall within the metes and bounds of the claims or that form their functional as well as conjointly cooperative equivalents, are therefore intended to be embraced by these claims.

What is claimed is:

1. A composition consisting essentially of polymethylmethacrylate, grated anorganic bone, dinitrosopentamethelene tetramine, and N-tributyl phosphate, the mixture comprising by weight 33l-58 /a% polymethylmethacrylate, 5-l2 /z% dinitrosopentamethelene tetramine, 10-16%% bone, and 16% 50% N-tri'butyl phosphate.

2. The method of making a plastic bone for implant purposes comprising the following steps:

A. forming a mixture comprising approximately by weight -70% of polymethylmethacrylate, 1015% dinitrosopentamethelene tetramine, and grated anorganic bone in an amount sufficient to provide 10- 16 /3% bone in the final product;

B. adding approximately 40-70% by weight of a monomer to the mixture of Step A;

5 6 C. adding approximately 20-100% by weight of N-tri- R f e Cited butyl phosphate to the resultant mixture of Step B; D. introducing the resultant mixture of Step C to a UNITED STATES PATENTS mold; 2,968,593 1/1961 Rapkin 128-1 R heating said mold; 3,320,188 5/1967 Dijkema 2602.5 R F. removing the molded mixture from said mold; and G. removing the outer skin from the molded mixture. FOREIGN PATENTS 3. In the method of claim 2, said heating step being at 718,685 11/1954 Great Britain 32-10 A approximately 300 F. for approximately 30 minutes. 752,915 2/1967 Canada 260-2.5 P

4. In the method of claim 2, the step of removing the 10 skin comprising sandblasting. WILBERT, J. BRIGGS, SR., Primary Examiner 5. The method of claim 2 further characterized in that the amount of anorganic bone in Step A is approximately Us 20% of the p 3- 1; 32 10 A, 10 R; 117 -132; 12s 92 c, 92 G;

6. A plastic bone implant made in accordance with 15 2 2 5 M the method of claim 2.

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3918100 *May 13, 1974Nov 11, 1975Us NavySputtering of bone on prostheses
US3984914 *Jul 24, 1974Oct 12, 1976Robert SchwartzOral implant
US4051598 *Apr 22, 1975Oct 4, 1977Meer SneerDental implants
US4141864 *Dec 16, 1977Feb 27, 1979University Of Virginia Alumni Patents FoundationOsseous cement composition
US4146936 *Dec 29, 1976Apr 3, 1979Sumitomo Chemical Company LimitedImplants for bones, joints and tooth roots
US4186486 *Nov 4, 1977Feb 5, 1980Maurice GordonDental prosthesis
US4296209 *Mar 26, 1980Oct 20, 1981Dobrivoje TomicMaterial as spongiosacement with effervescent reabsorptive effect
US4314380 *Sep 26, 1980Feb 9, 1982Koken Co., Ltd.Artificial bone
US4379694 *Nov 9, 1978Apr 12, 1983Neodontics, Inc.Dental implant
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US4547327 *Aug 8, 1984Oct 15, 1985Medical Biological Sciences, Inc.Method for producing a porous prosthesis
US4588583 *Oct 25, 1983May 13, 1986Beiersdorf AktiengesellschaftSurgical material
US4795475 *Aug 9, 1985Jan 3, 1989Walker Michael MProsthesis utilizing salt-forming oxyacids for bone fixation
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US5993716 *Dec 12, 1997Nov 30, 1999Draenert; KlausMaterial and process for its preparation
US6080801 *Jul 14, 1998Jun 27, 2000Klaus DraenertMulti-component material and process for its preparation
USB491501 *Jul 24, 1974Jan 13, 1976 Title not available
DE2658716A1 *Dec 22, 1976Jul 14, 1977Arthur Dr AshmanVerfahren zum herstellen von zahnprothesen bzw. implante
DE2752297A1 *Nov 23, 1977May 31, 1979Tomic DobrivojeMaterial als spongiosazement mit schaeumendem und resorbierbarem effekt
DE3005264A1 *Feb 13, 1980Aug 28, 1980Raab SProthese und verfahren zu deren herstellung
DE3005265A1 *Feb 13, 1980Aug 28, 1980Raab SProthese
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WO1982001989A1 *Nov 24, 1981Jun 24, 1982Medical Biolog Sciences IncOral prosthesis and method for producing same
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Classifications
U.S. Classification521/85, 623/23.61, 606/76, 433/201.1, 521/95, 521/63, 523/114, 521/149
International ClassificationC08K13/02, A61C13/00, A61L27/56, A61K6/083, A61C8/00, A61L27/46, A61K6/00
Cooperative ClassificationC08K13/02, A61K6/083, A61L27/46, A61C13/00, A61L27/56, A61K6/0023, A61C8/0028
European ClassificationA61K6/00B, C08K13/02, A61L27/46, A61L27/56, A61C13/00, A61C8/00F4, A61K6/083