|Publication number||US3789841 A|
|Publication date||Feb 5, 1974|
|Filing date||Sep 15, 1971|
|Priority date||Sep 15, 1971|
|Publication number||US 3789841 A, US 3789841A, US-A-3789841, US3789841 A, US3789841A|
|Original Assignee||Becton Dickinson Co|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (3), Referenced by (134), Classifications (6) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Disposable guide wire
US 3789841 A
A stainless steel core wire has a tapered portion at one end and a portion of uniform thickness at another end. A Teflon jacket encloses the portion having uniform thickness to form a proximal end and a flexible stainless steel spring encloses the tapered portion forming a distal end. The spring is secured at both ends to the stainless steel core wire.
United States Patent Antoshkiw 45 F b, 5 1974 DISPOSABLE GUIDE WIRE 3,547,103 12/1970 Cook 128/205 R Inventor: William T. Antoshkiw y, NJ 3,612,058 10/1971 Ackerman 128/348  Assignee: Becton, Dickinson 8!. Company, East Primary Examiner-Lucie H. Laudenslager Rutherford, NJ. Attorney, Agent, or Firm-Kane, Dalsimer, Kane, Sul- 22 Filed: Sept. 15, 1971 and ] Appl. No.: 180,810 57 ABSTRACT A stainless steel core wire has a tapered portion at one  U.S. Cl ..128/2.05 R end and a portion of uniform thickness at another end.  Int. Cl A61b 5/02 A Teflon jacket encloses the portion having uniform  Field of Search... 128/205 R, DIG. 9, 341, 348 thickness to form a proximal end and a flexible stainv less steel spring encloses the tapered portion forming a  References Cited distal end. The spring is secured at both ends to the UNITED STATES PATENTS stainless steel core wire. 3,452,740 7/1969 Muller 128/DIG. 9 UX 10 Claims, 2 Drawing Figures DISPOSABLE GUIDE WIRE BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to guide wires for vascular manipulations and more particularly to a disposable guide wire having added strength in the proximal portion and flexibility in the distal portion.
2. Description of the Prior Art The requirements for diagnostic studies of the vascular systems of the human body have increased considerably in recent years with the marked advances in the cardiac and vascular surgery. This increased requirement has led to extensive use of cardiac and vascular catheters that must be inserted over a relatively long distance into internal sites in the body. Extensive manipulation is required to maneuver a relatively long catheter into branch vessels that extend at sharp angles relative to the feeding direction of the catheter.
The most common catherization procedure is the percutaneous technique described in 1953 by Sven Ivar Seldinger. In the practice of this catherization procedure, an area of the skin is antiseptically prepared and a local anthestic is applied after which a nick is made in the skin over the site of a vessel to be catherized. An arterial needle assembly, (inner needle, stylet) is then introduced into the vessel and its introduction is indicated by a back flow of blood to the inner needle. The inner needle is then withdrawn and replaced with a guide wire which is then introduced through the cannula for a distance of approximately 6 to 10 inches. External pressure is then applied to hold the guide wire in place while the cannula is withdrawn after which the guide wire is fed into the vessel to the selected area by fluoroscopy or some other similar technique. Considerable manipulation is required of the guide line to direct it to the desired area. Once the guide wire reaches the selected area, the catheter is passed over the guide wire to the selected area after which the guide wire is withdrawn from the catheter.
Heretofore, guide wires were formed of closely wound stainless steel forming a continuous coil spring having an inner bore which is sealed at the distal end with arounded cap or tip. Usually an inner core wire is placed within the coil bore, said wire terminating a short distance from the distal tip to provide flexibility at the distal tip and rigidity throughout the remainder of the wire. In most cases, the proximal portion having the core wire was too rigid while the distal tip was so flexible it was practically uncontrollable.
In order to overcome the problems of the devices of the prior art, U. S. Pat. No. 3,528,406 taught the use of two core wires, one extending to the distal tip and the other terminating a distance therefrom. Another embodiment taught by the previously mentioned patent included a heavy gauge core wire throughout the proximal portion, the heavy gauge wire being reduced to a uniform thinner diameter at the distal tip portion to provide greater flexibility.
All the devices heretofore provided had a coil spring extending throughout their entire length and were therefore subject to coil breakage or breakage of the core wire. The coil spring and the core wire were not usually in contact and therefore did not provide mutual support for each other. The coil spring did not provide for good torque transmission because the spring would tend to bend and turn rather than transmit torque from the proximal portion to the distal tip of the guide wire. This feature made manipulation more difficult and time consuming.
The coil spring also had many other disadvantages, one being the high friction presented between the coils of the spring and the inner surface of the vessel. The spring coils tended to collect blood and were more difflcult to clean causing clot formation on the coils. The spring also presented an electrical hazard during cardiovascular catheterization.
SUMMARY OF THE INVENTION The present invention contemplates a flexible guide wire for use in vascular manipulations. The guide wire is disposable and comprises a stainless steel core wire having a portion of uniform diameter and a tapered portion. The uniform diameter portion is coated with a plastic jacket to form a proximal portion and the tapered portion is enclosed in a stainless steel coil spring to form a distal portion. The spring is fixed at both ends to the inner core by soldering, the solder at the end forming a rounded distal tip.
The stainless steel spring closing the distal portion provides the required flexibility and resiliency while permitting introduction of the guide wire through a stainless steel cannula without the danger of skiving during introduction of the wire. The danger of spring coil breakage is greatly reduced by reducing the spring length and by connecting it to the inner core at both ends. The tapered core wire at the distal portion provides for uniform increase in flexibility between the proximal portion and the distal tip.
The use of the plastic jacket around the proximal portion of the center of core wire provides several advantages. The use of the plastic jacket reduces the length of spring coil required and thereby greatly reduces the cost of the guide wire. Stainless steel spring material is the most expensive component of the guide wire and elimination of substantial length of spring material greatly reduces the cost. The plastic material provides a smooth low friction surface and thereby facilitates the movement of the guide wire through a vessel. The plastic jacket is easier to clean than the spring coil and prevents clotting between the coils of the spring. The plastic jacket is in direct contact with the inner core wire and therefore supports the wire and reduces the possibility of wire breakage while also providing for excellent torque transmission to the distal portion to facilitate manipulation of the guide wire. Use of an insulated plastic jacket eliminates the electrical hazard which was present during cardiovascular catheterization when devices of the prior art were used.
The primary objective of the present invention is to provide a disposable guide wire that need not be cleaned and sterilized after each use.
Another objective of the present invention is to provide a guide wire having better manipulative characteristics than guide wires heretofore provided.
Another objective of the present invention is to provide a guide wire having a low coefficient of friction and good torque transmitting ability.
Another objective of the present invention is to provide a guide wire that prevents clot formation.
Another objective of the present invention is to provide a guide wire that is not prone to breakage.
The foregoing objectives and advantages of the invention will appear more fully hereinafter from a consideration of the detailed description which follows, taken together with the accompanying drawing wherein one embodiment of the invention is illustrated by way of example. It is to be expressly understood, however, that the drawing is for illustrative purposes only and is not to be considered as defining the limits of the invention.
DESCRIPTION OF THE DRAWINGS FIG. 1 is a plan view of a flexible guide wire constructed in accordance with the present invention.
FIG. 2 is a sectional view taken along lines 22 of FIG. 1.
DESCRIPTION OF THE INVENTION Referring to the drawings, there is shown a stainless steel wire having a portion 12 of uniform thickness and a tapered portion 14. Portion 12 is covered by a jacket 16 made of a plastic material such as Teflon which has a smooth low friction outer surface. The plastic coated portion 12 forms a proximal portion of a guide wire.
A stainless steel coil spring 18 extends over tapered portion 14 and is soldered or otherwise connected to wire 10 at a point indicated by numeral 20 which is adjacent the end of jacket 16. Spring 18 also connected by soldering or otherwise to the end of the tapered portion 14 to form a distal tip 22 having a rounded outer surface.
The outer diameters of spring 18 and jacket 16 are substantially equal and vary from 0.021 to 0.047 of an inch. However, other diameters are contemplated and must be considered to be within the teachings of the present invention.
The guide wire may be manufactured from standard plastic coated stainless steel wire cut to any desired length such as 120 centimeters after which the plastic coating is stripped from the distal portion. The distal portion is then tapered by either a grinding procedure or by the application of a tension force to neck down the distal portion. The stainless steel spring is then positioned over the distal portion and soldered to the stainless steel core wire to form the disposable guide wire.
The flexible guide wire may be used following the standard techniques taught by Seldinger and as previously explained in the background of the invention. The distal portion has a rounded tip 22 and an increased amount of flexibility provided by the tapered core wire 14 while the proximal portion has a greater degree of rigidity provided by the uniform diameter of the core wire and the plastic jacket 16. The plastic jacket provides a smooth surface with a low coefficient of friction to facilitate insertion of the guide wire into a vessel while the Teflon jacket provides for excellent torque transmission making the guide wire exceptionally maneuverable.
The use of a plastic jacket eliminates the need for the coil spring to extend over the entire length of the guide wire and thus reduces the amount of spring material it required. The cost of the guide wire is substantially reduced as a result of the reduced amount of extensive stainless steel spring material required for the guide wire. Likewise, the tendency towards clot formation is greatly reduced by the smooth surface of the plastic jacket. The possibility of core wire breakage is greatly reduced by the use of the plastic jacket which is in contact with the proximal portion of the core wire and provides reinforcement. The tendency towards spring coil breakage is also reduced by the use of a shorter spring than in those devices heretofore provided. The plastic jacket also provides an additional advantage in that it eliminates the electrical hazard associated with devices of the prior art during cardiovascular catheterization.
It is to be understood that the teachings of the invention are not strictly limited to the materials recited above, but that other compatible materials may be used which are familiar to those skilled in the art.
What is claimed is:
1. A flexible guide wire, comprising:
an elongated inner core wire having a proximal portion and a distal portion;
a coil spring enclosing the distal portion and fixably attached thereto the coil spring including a proximal end and distal end; and
a plastic jacket enclosing and engaging the proximal portion the jacket including a proximal end and a distal end, the jacket distal end terminating at the coil spring proximal end and being substantially equal in diameter to the coil spring such that the jacket forms an extension of the coil spring.
2. A guide wire as described in claim 1, wherein the proximal portion is of uniform diameter.
3. A guide wire as described in claim 1, wherein the coil spring is attached to the inner core wire at both ends of the distal portion.
4. A guide wire as described in claim 1, wherein the inner core wire is made of stainless steel.
5. A guide wire as described in claim 1, wherein the coil spring is made of stainless steel.
6. A flexible guide wire, comprising:
an elongated inner core wire having a proximal portion and a tapered distal portion;
a coil spring enclosing the distal portion and fixably attached thereto; and
a plastic jacket enclosing and engaging the proximal portion.
7. A flexible guide wire, comprising:
an elongated inner core wire having a proximal portion and a distal portion the proximal portion of the inner core wire being of uniform diameter and the distal portion is tapered;
a coil spring enclosing the distal portion and fixably attached thereto; and
a plastic jacket enclosing and engaging the proximal portion.
8. A guide wire as described in claim 7, wherein the coil spring is attached to the inner core wire at both ends of the distal portion.
9. A guide wire as described in claim 8, wherein the inner core wire and the coil spring are formed of stainless steel.
10. A guide wire as described in claim 9, wherein the coil spring is attached to the inner core wire by soldering and the solder forms a distal tip at one end of the coil spring.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3452740 *||May 31, 1966||Jul 1, 1969||Us Catheter & Instr Corp||Spring guide manipulator|
|US3547103 *||Oct 29, 1965||Dec 15, 1970||William A Cook||Coil spring guide|
|US3612058 *||Apr 17, 1968||Oct 12, 1971||Electro Catheter Corp||Catheter stylets|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4003369 *||Apr 22, 1975||Jan 18, 1977||Medrad, Inc.||Angiographic guidewire with safety core wire|
|US4080706 *||Nov 4, 1976||Mar 28, 1978||Medrad, Inc.||Method of manufacturing catheter guidewire|
|US4402307 *||Oct 31, 1980||Sep 6, 1983||Datascope Corp.||Balloon catheter with rotatable energy storing support member|
|US4456017 *||Nov 22, 1982||Jun 26, 1984||Cordis Corporation||Coil spring guide with deflectable tip|
|US4538622 *||Nov 10, 1983||Sep 3, 1985||Advanced Cardiovascular Systems, Inc.||Guide wire for catheters|
|US4545390 *||Sep 22, 1982||Oct 8, 1985||C. R. Bard, Inc.||Steerable guide wire for balloon dilatation procedure|
|US4548206 *||Jul 21, 1983||Oct 22, 1985||Cook, Incorporated||Catheter wire guide with movable mandril|
|US4554929 *||Jul 13, 1983||Nov 26, 1985||Advanced Cardiovascular Systems, Inc.||Catheter guide wire with short spring tip and method of using the same|
|US4721117 *||Apr 25, 1986||Jan 26, 1988||Advanced Cardiovascular Systems, Inc.||Torsionally stabilized guide wire with outer jacket|
|US4732163 *||Nov 10, 1986||Mar 22, 1988||Sarcem S.A.||Remote controlled guide for a catheter|
|US4757827 *||Feb 17, 1987||Jul 19, 1988||Versaflex Delivery Systems Inc.||Steerable guidewire with deflectable tip|
|US4811743 *||Apr 21, 1987||Mar 14, 1989||Cordis Corporation||Catheter guidewire|
|US4813434 *||Mar 31, 1988||Mar 21, 1989||Medtronic Versaflex, Inc.||Steerable guidewire with deflectable tip|
|US4815478 *||Mar 31, 1988||Mar 28, 1989||Medtronic Versaflex, Inc.||Steerable guidewire with deflectable tip|
|US4830023 *||Nov 27, 1987||May 16, 1989||Medi-Tech, Incorporated||Medical guidewire|
|US4867173 *||Jun 30, 1986||Sep 19, 1989||Meadox Surgimed A/S||Steerable guidewire|
|US4867174 *||Nov 18, 1987||Sep 19, 1989||Baxter Travenol Laboratories, Inc.||Guidewire for medical use|
|US4873983 *||Jan 27, 1988||Oct 17, 1989||Advanced Biomedical Devices, Inc.||Steerable guidewire for vascular system|
|US4884579 *||Apr 18, 1988||Dec 5, 1989||Target Therapeutics||Catheter guide wire|
|US4922924 *||Apr 27, 1989||May 8, 1990||C. R. Bard, Inc.||Catheter guidewire with varying radiopacity|
|US4925445 *||Feb 9, 1989||May 15, 1990||Fuji Terumo Co., Ltd.||Guide wire for catheter|
|US4934380 *||Nov 23, 1988||Jun 19, 1990||Boston Scientific Corporation||Medical guidewire|
|US4971490 *||Sep 19, 1989||Nov 20, 1990||National Standard Company||Flexible guide wire with improved mounting arrangement for coil spring tip|
|US4976690 *||Mar 22, 1990||Dec 11, 1990||Scimed Life Systems, Inc.||Variable stiffness angioplasty catheter|
|US4984581 *||Oct 12, 1988||Jan 15, 1991||Flexmedics Corporation||Flexible guide having two-way shape memory alloy|
|US4991588 *||Nov 13, 1989||Feb 12, 1991||Pfizer Hospital Products Group, Inc.||Doppler guide wire|
|US5003918 *||Dec 28, 1989||Apr 2, 1991||Interventional Technologies, Inc.||Apparatus for manufacturing atherectomy torque tubes|
|US5054501 *||May 16, 1990||Oct 8, 1991||Brigham & Women's Hospital||Steerable guide wire for cannulation of tubular or vascular organs|
|US5059176 *||Dec 21, 1989||Oct 22, 1991||Winters R Edward||Vascular system steerable guidewire with inflatable balloon|
|US5067489 *||Oct 26, 1990||Nov 26, 1991||Flexmedics Corporation||Flexible guide with safety tip|
|US5095915 *||Mar 19, 1990||Mar 17, 1992||Target Therapeutics||Guidewire with flexible distal tip|
|US5102390 *||May 2, 1985||Apr 7, 1992||C. R. Bard, Inc.||Microdilatation probe and system for performing angioplasty in highly stenosed blood vessels|
|US5111829 *||Jan 18, 1991||May 12, 1992||Boston Scientific Corporation||Steerable highly elongated guidewire|
|US5147317 *||Jun 4, 1990||Sep 15, 1992||C.R. Bard, Inc.||Low friction varied radiopacity guidewire|
|US5171383 *||Sep 16, 1991||Dec 15, 1992||Terumo Kabushiki Kaisha||Method of manufacturing a differentially heat treated catheter guide wire|
|US5176149 *||Dec 27, 1991||Jan 5, 1993||Nivarox-Far S.A.||Catheter guide support|
|US5190546 *||Apr 9, 1991||Mar 2, 1993||Raychem Corporation||Medical devices incorporating SIM alloy elements|
|US5207229 *||Oct 1, 1990||May 4, 1993||Advanced Biomedical Devices, Inc.||Flexibility steerable guidewire with inflatable balloon|
|US5234003 *||Feb 20, 1992||Aug 10, 1993||Cook Incorporated||Flexible tip wire guide|
|US5238004 *||Sep 30, 1992||Aug 24, 1993||Boston Scientific Corporation||High elongation linear elastic guidewire|
|US5243988 *||Aug 7, 1992||Sep 14, 1993||Scimed Life Systems, Inc.||Intravascular imaging apparatus and methods for use and manufacture|
|US5243996 *||Jan 3, 1992||Sep 14, 1993||Cook, Incorporated||Small-diameter superelastic wire guide|
|US5287858 *||Sep 23, 1992||Feb 22, 1994||Pilot Cardiovascular Systems, Inc.||Rotational atherectomy guidewire|
|US5295493 *||Nov 10, 1992||Mar 22, 1994||Interventional Technologies, Inc.||Anatomical guide wire|
|US5313967 *||Jul 24, 1992||May 24, 1994||Medtronic, Inc.||Helical guidewire|
|US5333620 *||Sep 8, 1993||Aug 2, 1994||C. R. Bard, Inc.||High performance plastic coated medical guidewire|
|US5345945 *||Dec 25, 1993||Sep 13, 1994||Baxter International Inc.||Dual coil guidewire with radiopaque distal tip|
|US5353798 *||Feb 21, 1992||Oct 11, 1994||Scimed Life Systems, Incorporated||Intravascular imaging apparatus and methods for use and manufacture|
|US5368035 *||Sep 17, 1992||Nov 29, 1994||Boston Scientific Corporation||Ultrasound imaging guidewire|
|US5377690 *||Feb 9, 1993||Jan 3, 1995||C. R. Bard, Inc.||Guidewire with round forming wire|
|US5396902 *||May 28, 1993||Mar 14, 1995||Medtronic, Inc.||Steerable stylet and manipulative handle assembly|
|US5402799 *||Jun 29, 1993||Apr 4, 1995||Cordis Corporation||Guidewire having flexible floppy tip|
|US5409015 *||May 11, 1993||Apr 25, 1995||Target Therapeutics, Inc.||Deformable tip super elastic guidewire|
|US5415170 *||Aug 27, 1993||May 16, 1995||Pilot Cardiovascular Systems, Inc.||Rotational atherectomy guidewire|
|US5438997 *||Jun 8, 1992||Aug 8, 1995||Sieben; Wayne||Intravascular imaging apparatus and methods for use and manufacture|
|US5443443 *||Aug 17, 1993||Aug 22, 1995||Surgical Systems & Instruments, Inc.||Atherectomy system|
|US5488959 *||Dec 27, 1993||Feb 6, 1996||Cordis Corporation||Medical guidewire and welding process|
|US5498250 *||May 18, 1994||Mar 12, 1996||Scimed Life Systems, Inc.||Catheter guide wire with multiple radiopacity|
|US5546948 *||Nov 28, 1994||Aug 20, 1996||Boston Scientific Corporation||Ultrasound imaging guidewire|
|US5551444 *||May 31, 1995||Sep 3, 1996||Radius Medical Technologies, Inc.||Flexible guidewire with radiopaque outer coil and non-radiopaque inner coil|
|US5596996 *||Mar 30, 1995||Jan 28, 1997||Medtronic, Inc.||High support nitinol tube guidewire with plastic plug transition|
|US5597378 *||Oct 2, 1992||Jan 28, 1997||Raychem Corporation||Medical devices incorporating SIM alloy elements|
|US5599492 *||Dec 16, 1994||Feb 4, 1997||Target Therapeutics, Inc.||Method for making a guidewire with a flexible distal tip|
|US5636642 *||Apr 25, 1995||Jun 10, 1997||Target Therapeutics, Inc.||Deformable tip super elastic guidewire|
|US5662119 *||Apr 21, 1995||Sep 2, 1997||Medtronic Inc.||Steerable stylet and manipulative handle assembly|
|US5664580 *||Jan 31, 1995||Sep 9, 1997||Microvena Corporation||Guidewire having bimetallic coil|
|US5673707 *||Sep 23, 1994||Oct 7, 1997||Boston Scientific Corporation||Enhanced performance guidewire|
|US5682894 *||Apr 26, 1996||Nov 4, 1997||Orr; Gregory C.||Guide wire|
|US5746701 *||Sep 14, 1995||May 5, 1998||Medtronic, Inc.||Guidewire with non-tapered tip|
|US5749837 *||Aug 1, 1996||May 12, 1998||Target Therapeutics, Inc.||Enhanced lubricity guidewire|
|US5769796 *||Jan 22, 1997||Jun 23, 1998||Target Therapeutics, Inc.||Super-elastic composite guidewire|
|US5772609 *||Jun 28, 1996||Jun 30, 1998||Target Therapeutics, Inc.||Guidewire with variable flexibility due to polymeric coatings|
|US5827201 *||Jul 26, 1996||Oct 27, 1998||Target Therapeutics, Inc.||Micro-braided guidewire|
|US5830155 *||Oct 27, 1995||Nov 3, 1998||Cordis Corporation||Guidewire assembly|
|US5836892 *||Oct 30, 1995||Nov 17, 1998||Cordis Corporation||Guidewire with radiopaque markers|
|US5851206 *||Jun 30, 1995||Dec 22, 1998||The Regents Of The University Of California||Method and apparatus for endovascular thermal thrombosis and thermal cancer treatment|
|US5865768 *||Sep 30, 1996||Feb 2, 1999||Medtronic, Inc.||Guide wire|
|US5873842 *||Jun 26, 1997||Feb 23, 1999||Medtronic, Inc.||Steerable stylet and manipulative handle assembly|
|US5916178 *||May 5, 1997||Jun 29, 1999||Medtronic, Inc.||Steerable high support guidewire with thin wall nitinol tube|
|US5919187 *||Sep 15, 1995||Jul 6, 1999||The Regents Of The University Of California||Method and apparatus for endovascular thermal thrombosis and thermal cancer treatment|
|US5925059 *||Dec 21, 1994||Jul 20, 1999||Target Therapeutics, Inc.||Detachable embolic coil assembly|
|US5951568 *||Mar 19, 1998||Sep 14, 1999||Schatz; Richard A.||Over the wire single operator catheter with wire stabilizer|
|US5957865 *||Sep 25, 1997||Sep 28, 1999||Merit Medical Systems, Inc.||Flexible catheter guidewire|
|US6099485 *||Jun 3, 1997||Aug 8, 2000||C. R. Bard, Inc.||Torquable, low mass medical guidewire|
|US6099546 *||Jan 13, 1997||Aug 8, 2000||Target Therapeutics, Inc.||Detachable embolic coil assembly using interlocking hooks and slots|
|US6139510 *||May 11, 1994||Oct 31, 2000||Target Therapeutics Inc.||Super elastic alloy guidewire|
|US6306141||Jun 7, 1995||Oct 23, 2001||Medtronic, Inc.||Medical devices incorporating SIM alloy elements|
|US6488637||Apr 30, 1996||Dec 3, 2002||Target Therapeutics, Inc.||Composite endovascular guidewire|
|US6673025||Nov 16, 1999||Jan 6, 2004||Advanced Cardiovascular Systems, Inc.||Polymer coated guidewire|
|US6755794 *||Apr 25, 2001||Jun 29, 2004||Synovis Life Technologies, Inc.||Adjustable stylet|
|US7455646||Jun 26, 2007||Nov 25, 2008||Advanced Cardiovascular Systems, Inc.||Polymer coated guide wire|
|US7494474||Jul 31, 2003||Feb 24, 2009||Advanced Cardiovascular Systems, Inc.||Polymer coated guidewire|
|US7540845||Sep 5, 2003||Jun 2, 2009||Boston Scientific Scimed, Inc||Medical device coil|
|US7763077||Dec 24, 2003||Jul 27, 2010||Biomerix Corporation||Repair of spinal annular defects and annulo-nucleoplasty regeneration|
|US7803395||May 17, 2004||Sep 28, 2010||Biomerix Corporation||Reticulated elastomeric matrices, their manufacture and use in implantable devices|
|US7833175||Sep 5, 2003||Nov 16, 2010||Boston Scientific Scimed, Inc.||Medical device coil|
|US7883474||Apr 30, 1996||Feb 8, 2011||Target Therapeutics, Inc.||Composite braided guidewire|
|US7892186||Dec 9, 2005||Feb 22, 2011||Heraeus Materials S.A.||Handle and articulator system and method|
|US8118827||Mar 14, 2003||Feb 21, 2012||Cordis Corporation||Total occlusion guidewire device|
|US8241230||Sep 25, 2007||Aug 14, 2012||Cook Medical Technologies Llc||Variable stiffness wire guide|
|US8308658||Apr 13, 2007||Nov 13, 2012||Neometrics, Inc.||Medical guidewire|
|US8428747||Jun 25, 2004||Apr 23, 2013||The Spectranetics Corp.||Lead locking device and method|
|US8556926||Nov 16, 2011||Oct 15, 2013||Cordis Corporation||Total occlusion guidewire device|
|US8961555||Mar 14, 2013||Feb 24, 2015||Cordis Corporation||Total occlusion guidewire device|
|US8968350||Mar 14, 2013||Mar 3, 2015||Cordis Corporation||Total occlusion guidewire device|
|US9017246||Nov 17, 2011||Apr 28, 2015||Boston Scientific Scimed, Inc.||Biliary catheter systems including stabilizing members|
|US20060271067 *||May 24, 2005||Nov 30, 2006||C.R. Bard, Inc.||Laser-resistant surgical devices|
|USRE33911 *||Mar 27, 1986||May 5, 1992||Advanced Cardiovascular Systems, Inc.||Catheter guide wire with short spring tip and method of using the same|
|USRE34695 *||Oct 29, 1992||Aug 16, 1994||Advanced Cardiovascular Systems, Inc.||Torsionally stabilized guide wire with outer jacket|
|USRE36628 *||Oct 16, 1997||Mar 28, 2000||Terumo Kabushiki Kaisha||Method of manufacturing a differentially heat treated catheter guide wire|
|USRE37117||Jul 7, 1997||Mar 27, 2001||Target Therapeutics, Inc.||Detachable embolic coil assembly using interlocking clasps and method of use|
|USRE42625||Mar 15, 2006||Aug 16, 2011||The Regents Of The University Of California||Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas|
|USRE42662||Mar 15, 2006||Aug 30, 2011||The Regents Of The University Of California||Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas|
|USRE42756||Mar 15, 2006||Sep 27, 2011||The Regents Of The University Of California||Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas|
|DE3334174A1 *||Sep 21, 1983||Mar 22, 1984||Bard Inc C R||Lenkbarer fuehrungsdraht fuer die ballondilatation|
|DE3528876A1 *||Aug 12, 1985||Feb 19, 1987||Schubert Werner||Guiding wire|
|DE19607595C2 *||Feb 29, 1996||Jan 20, 2000||Epflex Feinwerktech Gmbh||Führungsdrahtkern, insbesondere für ein chirurgisches Instrument|
|EP0014424A1 *||Jan 29, 1980||Aug 20, 1980||Toray Monofilament Company Limited||Medical vascular guide wire and self-guiding type catheter|
|EP0157862A1 *||Oct 4, 1984||Oct 16, 1985||Maerz Peter Dr||Guiding mandrel for catheter and similar instruments and manufacturing process thereof.|
|EP0200430A1 *||Apr 17, 1986||Nov 5, 1986||Advanced Cardiovascular Systems, Inc.||Torsional guide wire with attenuated diameter|
|EP0200919A1 *||Apr 2, 1986||Nov 12, 1986||ANGIOMED Aktiengesellschaft||Guide wire|
|EP0223179A2 *||Nov 10, 1986||May 27, 1987||Sarcem Sa||Remotely controlled catheter guide|
|EP0340304A1 *||Dec 25, 1987||Nov 8, 1989||Terumo Kabushiki Kaisha||Guide wire for catheters and method of manufacturing same|
|EP0820782A2||Jul 10, 1997||Jan 28, 1998||Target Therapeutics, Inc.||Micro-braided catheter guidewire|
|EP0914803A1||Jan 3, 1991||May 12, 1999||The Regents Of The University Of California||Endovascular electrolytically detachable guidewire tip|
|EP1005837A2||Sep 30, 1992||Jun 7, 2000||The Regents Of The University Of California||Endovascular electrolytically detachable wire for thrombus formation|
|EP1287846A2||Apr 4, 1997||Mar 5, 2003||Target Therapeutics, Inc.||Composite endovascular guidewire|
|EP1323385A2||Sep 30, 1992||Jul 2, 2003||The Regents of The University of California||Endovascular electrolytically detachable wire for thrombus formation|
|EP1329196A1||Jan 3, 1991||Jul 23, 2003||The Regents of the University of California||Endovascular electrolytically detachable guidewire tip|
|WO1989006985A1 *||Jan 27, 1989||Aug 10, 1989||Advanced Biomedical Devices In||Steerable guidewire for vascular system|
|WO1989010088A1 *||Apr 14, 1989||Nov 2, 1989||Target Therapeutics Inc||Catheter guide wire|
|WO1991017698A1 *||May 15, 1991||Nov 17, 1991||Brigham & Womens Hospital||Steerable guide wire for tubular cannulation|
|WO1992008501A1 *||Oct 3, 1991||May 29, 1992||Medtronic Inc||Fixed wire catheter and unitary guidewire|
|WO2010078544A1||Jan 4, 2010||Jul 8, 2010||Vance Products Incorporated D/B/A Cook Urological Incorporated||Medical guide wire and method of forming thereof|