US3791932A - Process for the demonstration and determination of reaction components having specific binding affinity for each other - Google Patents
Process for the demonstration and determination of reaction components having specific binding affinity for each other Download PDFInfo
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- US3791932A US3791932A US00221447A US3791932DA US3791932A US 3791932 A US3791932 A US 3791932A US 00221447 A US00221447 A US 00221447A US 3791932D A US3791932D A US 3791932DA US 3791932 A US3791932 A US 3791932A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
- G01N33/541—Double or second antibody, i.e. precipitating antibody
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/971—Capture of complex after antigen-antibody reaction
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
- Y10S436/818—Human chorionic gonadotropin
Definitions
- ABSTRACT The present invention relates to a process for the determination of a component of the reaction between a specific binding protein and the substance being specifically bound by such a protein comprising reacting the component to be determined with its binding partner in an insolubilized form, separating the solid phase of the reaction mixture from the liquid phase, reacting the solid phase with a determined amount of a coupling product of the substance to be determined with an enzyme, and finally determining the enzyme activity of the liquid or solid phase of the reaction mixture obtained.
- a low molecular substance chemically with a protein
- a test animal which then reacts by forming antibodies against, among others, the low molecular substance.
- the latter is in this case to be regarded as a socalled hapten.
- the antibodies against the hapten may be regarded as a special case of specific binding proteins.
- High molecular substances such as simple and conjugated proteins and carbohydrates, are capable of causing the formation of antibodies on being injected into animals in the correct experimental conditions. Between these antibodies and the injected high molecular substance, the antigen, there is again question of specific binding affinity.
- Determination methods in which these specific binding affinities are employed are often based on the competition between the substance to be determined in the sample and the known quantity of the same substance, labelled radioactive, for a limited quantity of its binding partner.
- the quantity of substance to be determined determines what part of the radioactive labelled substance can be bound by its binding partner. It is also possible to determine an unknown quantity of specific binding protein by reacting a sample of it with a certain quantity of radioactive labelled, specific binding substance.
- the terms by which these methods are designated in the literature depend upon the nature of the specific binding protein. They speak of competitive protein binding assays, where receptor or transport proteins are used, and of"radioimmunological determinations" where antibodies are employed as specificbinding protein.
- an enzyme as a labelling substance.
- the low molecular substance can be coupled with an enzyme.
- the coupling product, low molecular substance/enzyme can then be used in experimental set-ups as described above.
- the antigen may, for example, be coupled with an enzyme instead of labelling it with a radioactive isotope as is conventional in radioimmunological methods.
- a suitable method for separating the free labelled compound attached to the binding partner is essential.
- various separation methods can be employed, for example electrophoresis, gel filtration, selective adsorption, application of one of the reaction components in an insolubilised form, and application of antibodies against one of the reaction components, also in an insolubilised form.
- HCG human chorionic gonadotrophin
- LH luteinizing hormone
- a process has now been found for the demonstration and determination of a component of the reaction between specific binding proteins and the substances that can be specifically bound by these proteins, using the known binding affinity of such components for each other, which comprises reacting the component to be determined with its binding partner, which has been or is insolubilised, separating the solid phase of the reaction mixture from the liquid phase, reacting the solid phase with a coupling product, obtained by binding a substance capable of reacting specifically with one of the reaction components, to an enzyme, and finally determining the enzyme activity of the liquid or the solid phase in the reaction mixture obtained, which is a measure for the quantity of the substance to be determined.
- the binding partner required for the determination of the component present in an unknown quantity is employed in an insoluble form.
- the determination can take place by adding the binding partner to the reaction mixture in an insoluble form and reacting the mixture in a heterogeneous medium, but the binding partner can also be added in a dissolved form, after which it can be insolubilised by adding antisubstances against it.
- the substance capable of reacting specifically with one of the reaction components, and which is employed coupled with an enzyme may be the other reaction component, but also a third substance that must possess a specific affinity for one of the components of the reaction.
- the method can be applied to the various reaction systems described above, i.e. antigen/antibody, hapten- /antibody and a low molecular substance/specific binding protein.
- a second antibody may occur, that is to say, an antibody against the gammaglobulin fraction of the species of animal in which the first antibodies have been generated. This situation may occur in the systems antigen/(first) antibody and hapten/(first) antibody.
- third substance may also occur an antibody against a specific binding protein.
- the essence of the method is the performance in two steps, in between which a separation takes place of the liquid and the solid phase of the reaction mixture. With the solid phase the second step is performed. Only in this stage the enzyme coupling product is employed and the enzyme activity determined.
- the first step can be performed in a larger volume than is desirable or possible for the second step. This is of great importance when the substance to be determined occurs in too low concentrations to be determined by known methods.
- liquid to be examined substances may be present influencing the reactions in the second step unfavourably.
- the enzyme present in the coupling product and the enzymatic catalysing reaction may be sensitive to disturbing substances in the test liquid.
- the method found can especially be employed for the determination of substances present in body liquids such as hormones, their antibodies and specific binding proteins, as well as enzymes. Also factors of bloodclotting, fibrinolysis and complement systems, pathological proteins in body liquids, as well as antibodies against pathogenic microorganisms and iso-antibodies can be determined in this manner.
- the medium in which the first step of the determination takes place often consists for a large part of test liquid, such as urine or serum. If considered necessary, it can be adjusted to the pH required for the immunochemical reaction, viz. between 5 and 9, by adding a dry buffer salt or a small volume of a concentrated buffer solution.
- the medium of the second step is also a buffer of a pH required for the immunochemical reaction.
- phosphate buffers, citrate buffers, tris(hydroxy methyl)-aminomethane, and imidazole buffers can be employed. It may be necessary to use for the relative enzyme reaction a buffer of another composition and pH, which depends upon the enzyme employed.
- the manufacture of the insolubilised reaction component can take place in various manners, i.a. dependent upon the properties of this reaction component.
- antibodies, specific binding proteins and proteinlike antigen can be insolubilised by cross-linking, for example, glutaric aldehyde and chloroformic acid ethyl ester, by physical adsorption or chemical coupling with an insoluble carrier, such as cellulose compounds, agarose, cross-linked dextran, polystyrene and the like, or by coupling with antibodies against the relative protein coupled with an insoluble carrier.
- Low molecular substances can be bound by methods dependent upon the structure of the low molecular substance and the carrier material. Some of the low molecular substances may already possess groups capable of reacting with the reactive parts on the carrier material: in other cases such groups will have to be introduced by organic chemical reactions.
- the manufacture of the enzyme coupling products is also performed by methods dependent upon the properties of the molecules incorporated into the coupling product.
- a covalent bond of proteins to enzymes can be effected by reagents such as carbodiimides, diisocyanates, glutaric aldehyde and bis-diazobenzidine.
- the coupling of low molecular substances can take place in various manners. Some of these substances may already possess groups that can be cross-linked with reactive groups of the enzyme; in other cases such groups will have to be introduced by organic chemical reactions. It stands to reason that in the manufacture of these coupling products the original binding properties of the substances bound to the enzyme may not change very much; no more may the enzyme activity be decreased considerably.
- the choice of the enzyme that is to form a part of the coupling product is determined by properties such as the specific binding activity (a high conversion rate raises the sensitivity of the test system) and the simplicity of the determination of the enzyme.
- the determination of an enzyme catalysing a conversion in which coloured reaction components are involved, is simple. Such colorimetric determinations can be automated in a simple manner.
- enzymes such as catalase, peroxidase, B-glucuronidase, B-B- glucosidase, ,B-D-galactosidase, urease, glucoseoxidase and galactose-oxidase are preferred, especially the group of the oxidoreductases.
- test liquid for example 10 ml, containing a very low concentration of the component to be determined
- test liquid may be urine, in which the component to be determined occurs in low concentration, or serum, which has been diluted to diminish the influence of disturbing factors.
- the mixture is agitated.
- the resulting solid phase is separated from the test liquid, for example by centrifugation, and washed, if considered necessary.
- the first part of the determination can also be performed by incubating the test liquid with a certain quantity of the reaction partner of the substance to be determined in a dissolved form, after which a quantity of insolubilised antibody against that reaction partner is added and the mixture agitated and finally centrifuged. Separation by filtration and decantation is also possible.
- the second part of the determination is performed by resuspending the insoluble substance, which forms the The enzyme activity of a phase of the reaction mixture is demonstrated or measured by incubating that phase with a substrate and other substances required for the relative enzyme reaction.
- a reaction is employed in which a coloured compound is formed, or removed, whose adsorption can be easily quantitatively determined.
- the form in which the reagents can be used are manifold.
- the component of the reaction system coupled with an enzyme may have been dissolved in a buffer, or freeze-dried.
- a solid carrier can be used, for example a strip of paper impregnated with the enzyme coupling product.
- the insoluble component can be processed in the form of particles of various sizes, such as grains, plates and rods, or in the form of a strip of some or other carrier material.
- test-pack is usually employed, chiefly consisting of:
- the test-pack can contain the necessary auxiliaries, if required, to make a dilution series of the sample to be tested for a quantitative determination, such as test tubes, pipettes and flasks containing a diluent.
- the test-pack contains at least:
- HCG-HRP horse-radish peroxidase
- the enzyme activity was determined in the supernatant liquid by adding 0.5 ml of it to 1.5 ml of a substrate solution consisting of 10 ul of 30% H 0 and 20 mg of 5-amino salicylic acid in ml of0.02 M phosphate buffer of pH 6.0. After 30 minutes the extinction was measured at 460 nm.
- the HCG content of serum of pregnant women could be determined in this experimental set-up provided that the serum sample was diluted in the ratio of at least 1:3.
- HCG human chorionic gonadotrophin
- the cellulose was centrifuged for minutes at 3,000 rpm. and resuspended in 1 ml of a solution of HCG- l-IRP coupling product, prepared in accordance with example I a), diluted to the desired strength with 0.01 M phosphate buffer of pH 6.0 with 2 percent normal sheep serum. The mixture was stirred again for 2 hours. After centrifugation the enzyme activity was determined in the supernatant liquid by adding 0.5 m] of it to 1.5 ml of enzyme substrate consisting of 10 pl of 30 percent H 0 and 20 mg of 5-amino-salicylic acid in 150 ml of 0.01 M phosphate buffer of pH 6.0. The mixture was left to stand for 30 minutes at 25, after which the extinction was measured at 460 nm. In the supernatant liquid 100 percent enzyme activity is measured provided that no anti-HCG serum is added to the system.
- the centrifugation step effects a ten times higher sensitivity than can be reached in a system without centrifugation.
- EXAMPLE III Determination of HCG and LH in low concentrations by means of an enzyme/antibody coupling product.
- HCG cellulose Preparation of the immune-adsorbent HCG cellulose.
- This immuno-adsorbent was prepared by the method mentioned in example I c), but instead of rabbit-y-globulin, 100 mg of HCG were coupled to 500 mg of m-aminobenzyloxymethyl cellulose.
- HCG and LH Determination of HCG and LH.
- Ten ml of a HCG dilution series of HCG and 10 ml ofa HCG dilution series of LH were mixed with 5 mg of anti-HCG cellulose, prepared in accordance with example I c), which was suspended in 1 ml of 0.15 M phosphate buffer of pH 6.0, and the mixtures rotate at room temperature for 2 hours.
- the immunoadsorbent was centrifuged and washed with 5 ml of 0.05 M phosphate buffer of pH 6.0.
- Rabbit-serum was fractionated over DEAE cellulose in accordance with the prescription of H.A. Sober and others in J. Am. Chem. Soc. 78, 756 (1956).
- the isolated y-globulin fraction which was immuno-electrophoretically pure, was partly used for generating antibodies in a sheep in accordance with the scheme of example [I a), while besides 100 mg of rabbit-y-globulin was coupled to 500 mg of m-aminobenzyloxymethyl cellulose by the method described in example I c).
- Rabbit-(anti-HCG) serum (0.5 ml) was rotated with 0.25 mg of HCG-cellulose for 2 hours (see example 111 a).
- the reaction mixture was centrifuged and the precipitate washed four times with phosphate buffer, each time with 3 ml, after which the precipitate was resuspended in 1 ml of a solution of the coupling product b.
- the mixture obtained was again rotated for 2 hours. After centrifugation the enzyme activity in the supernatant liquid was determined, as described in example l d).
- HCG HCG was determined by incubating solutions of it with 0.5 ml of rabbit-(anti-HCG)-serum in a dilution which in the system described under just causes an almost maximum reduction in enzyme activity in the supernatant liquid, and performing the process described under c) with the mixture obtained.
- Cavia -y-globulin was prepared by adding one volume of a saturated ammonium sulphate solution to two volumes of cavia serum. The resulting precipitate was washed twice with 33 percent saturated (NH S0 solution and then taken up in a physiological salt solution.
- a sheep was immunized with increasing dosages of the 'y-globulin prepared, viz. 0, 5, 1 and 2 mg. The injections were given every 2 weeks, the immunogen being mixed with complete Freunds adjuvant. Two weeks after the last injection another 2 mg of y-globulin, in a physiological salt solution, were given. One week later the animal was exsanguinated.
- the activated cellulose was mixed with 40 ml ofa 0.1
- the substrate solution contained mg of glucose, 10 ugm of peroxidase and 1 mg of S-aminosalicylic acid per 2.5 ml of 0.05 M phosphate buffer of pH 6.0.
- the centrifugation step serving both to raise the maximum volume of the test liquid to be employed and to remove serum factors disturbing the reaction, caused a lO-fold increase in sensitivity, so that a concentration of a few ng/ml of insulin could be demonstrated.
- oestradiol-l7-succinyl-l-1RP Fifty mg of oestradiol-l7-haemisuccinate and 0.08 ml of tri-n-butylamine were dissolved in 2.5 ml of diox ane. To the cold solution (2C) 15 u] of isobutylchlorocarbonate were added. After 30 minutes this solution was mixed with mg of horse radish peroxidase (HRP) in 7.5 ml of a mixture of dioxane and water (2:3), which had been adjusted to pH 9.5 with caustic soda. This solution was stirred for 4 hours at 2C, after which it was dialysed for 18 hours.
- HRP horse radish peroxidase
- the precipitate obtained after the pH of the dialysate had been adjusted to 4.6 was centrifuged, washed, and taken up in 5 ml of distilled water, which had been adjusted to pH 8.
- the material was purified further by precipitating it twice with 10 ml of acetone.
- the ultimate product was taken up in 10 ml of 0.05 M phosphate buffer of pH 7.8.
- oestradiol-l7-succinyl-BSA Preparation of oestradiol-l7-succinyl-BSA.
- the preparation was prepared by the mixed anhydride method as described under a).
- the starting material was 100 mg of oestradiol-l7-haemisuccinate and mg of bovine serum albumin (BSA).
- BSA bovine serum albumin
- the 'y-globulin fraction of the anti-sera described under 12) was prepared by precipitation with 18 percent w/v Na SO
- the product obtained was coupled with cellulose by Gurvichs method described in example I c).
- oestradiol A dilution series of oestradiol (00.5124-8l6 ng/ml) was prepared in phisphate buffer of pH 6.0. Five ml of sample were mixed with 0.5 ml of the sheep-antioestradiol-serum in the desired dilution. After incubating the mixture for 2 hours at room temperature 1 ml of immunoadsorbent suspension (see e) of 60 mg/ml was added, after which the mixture was rotated for 4 hours at room temperature. The cellulose was centrifuged and washed with 5 ml of 0.05 M phosphate buffer of pH 6.0 containing 2 percent BSA.
- concentrations of 1 ng/ml of oestradiol could be demonstrated, which means an increase in sensitivity by a factor 10, compared with the test without centrifugation step.
- the Sepharose was washed with ice-water and with 0.1 M NaHCO;,, after which mg of transcortine in 20 ml 0g 0.1 M NaHCO:, were added, and the suspension was shaken at 4C for 24 hours, After being washed successively with 0.5 M NaHCO;, 0.05 M citrate buffer of pH 1.1 and 0.05 M phosphate buffer of pH 6.0, the Sepharose was kept in the last buffer, to which 0.1 percent merthiolate had been added.
- cortisol A cortisol dilution series, in the range of from 0.25-16 ng/ml was prepared in 0.05 M phosphate buffer of pH 6.0. File ml of each cortisol solution (in 0.5 M phosphate buffer of pH 6.0) were rotated overnight with 5 mg of transcortine-Sepharose, at 4C. After centrifugation 1 ml of cortisol-2l-galactose oxidase solution, diluted to a suitable concentration in the buffer mentioned before, was added, after which the mixture was rotated for 2 hours at 4C.
- the enzyme activity in the supernatant liquid was determined by adding 0.5 ml of it to 1.5 ml of substrate constisting of 100 mg of D- galactose, 20 mg of S-amino-salicylic acid and 10 ugm of peroxidase in ml of 0.02 M phosphate buffer of pH 6.0. Finally, after 30 minutes, the extinction was measured at 460 nm.
- reaction mixture having a solid phase and a liquid phase
Abstract
The present invention relates to a process for the determination of a component of the reaction between a specific binding protein and the substance being specifically bound by such a protein comprising reacting the component to be determined with its binding partner in an insolubilized form, separating the solid phase of the reaction mixture from the liquid phase, reacting the solid phase with a determined amount of a coupling product of the substance to be determined with an enzyme, and finally determining the enzyme activity of the liquid or solid phase of the reaction mixture obtained.
Description
United States Patent [191 Schuurs et al.
[451 Feb. 12, 1974 [75] Inventors: Antonius Hermanus Wilhelmus Maria Schuurs; Bauke Klaas Van Weemen, both of Oss, Netherlands [73] Assignee: Akzona Incorporated, Asheville,
22 Filed: Jan. 27, 1972 21 App]. No.: 221,447
[30] Foreign Application Priority Data Feb. 10, 1971 Netherlands 7101728 [52] US. Cl. 195/l03.5 R, 424/12, 23/230 B [51] Int. Cl. G0ln 31/14 [58] Field of Search 195/103.5 R; 23/230 B; 424/12 [56] References Cited UNITED STATES PATENTS 3,654,090 4/1972 Schuurs et al. 195/1035 R Primary Examiner-Alvin E. Tanenholtz Assistant ExaminerMax D. Hensley Attorney, Agent, or Firm--Hugo E. Weisberger [57] ABSTRACT The present invention relates to a process for the determination of a component of the reaction between a specific binding protein and the substance being specifically bound by such a protein comprising reacting the component to be determined with its binding partner in an insolubilized form, separating the solid phase of the reaction mixture from the liquid phase, reacting the solid phase with a determined amount of a coupling product of the substance to be determined with an enzyme, and finally determining the enzyme activity of the liquid or solid phase of the reaction mixture obtained.
4 Claims, N0 Drawings PROCESS FOR THE DEMONSTRATION AND DETERMINATION OF REACTION COMPONENTS HAVING SPECIFIC BINDING AFFINITY FOR EACH OTHER For the demonstration and determination of substances playing a prominent part in biochemical processes, i.e. low molecular substances, such as vitamins and steroids, or high molecular ones, such as proteins and carbohydrates, it is often possible to employ reactions of these substances with proteins having a specific binding affinity for these substances. Thus, it is possible to determine the concentration of a steroid by employing a protein capable of binding this steroid specifically. As examples of such combinations are mentioned cortisol and transcortin, l7B-oestradiol and the oestradiol-binding receptor protein of the uterus.
It is also possible to link a low molecular substance chemically with a protein, and to inject this conjugate into a test animal, which then reacts by forming antibodies against, among others, the low molecular substance. The latter is in this case to be regarded as a socalled hapten. The antibodies against the hapten may be regarded as a special case of specific binding proteins.
High molecular substances, such as simple and conjugated proteins and carbohydrates, are capable of causing the formation of antibodies on being injected into animals in the correct experimental conditions. Between these antibodies and the injected high molecular substance, the antigen, there is again question of specific binding affinity.
Determination methods in which these specific binding affinities are employed, are often based on the competition between the substance to be determined in the sample and the known quantity of the same substance, labelled radioactive, for a limited quantity of its binding partner. The quantity of substance to be determined determines what part of the radioactive labelled substance can be bound by its binding partner. It is also possible to determine an unknown quantity of specific binding protein by reacting a sample of it with a certain quantity of radioactive labelled, specific binding substance. The terms by which these methods are designated in the literature, depend upon the nature of the specific binding protein. They speak of competitive protein binding assays, where receptor or transport proteins are used, and of"radioimmunological determinations" where antibodies are employed as specificbinding protein.
Instead of labelling one of the components of the above-described reactions with a radioactive isotope, it is also possible to employ an enzyme as a labelling substance. Where use is made of the binding affinity between a low molecular substance and its specif c binding protein, the low molecular substance can be coupled with an enzyme. The coupling product, low molecular substance/enzyme, can then be used in experimental set-ups as described above. Where use is made of the binding affinity between an antigen and its antibody, the antigen may, for example, be coupled with an enzyme instead of labelling it with a radioactive isotope as is conventional in radioimmunological methods.
For all the methods in which such a labelled reaction component is employed, a suitable method for separating the free labelled compound attached to the binding partner, is essential. Dependent upon the nature of the substances participating in the reaction, various separation methods can be employed, for example electrophoresis, gel filtration, selective adsorption, application of one of the reaction components in an insolubilised form, and application of antibodies against one of the reaction components, also in an insolubilised form.
In spite of the high sensitivity that can be achieved by these methods, it is not always possible to demonstrate or determine substances occurring in extremely low concentrations in, for example, serum or urine. Thus, it is very difficult and often impossible to demonstrate adrenocorticotrophic hormone (ACTH) by a radioimmunological method, unless one has the disposal of a very rare antiserum containing antisubstances with an extremely high binding affinity for ACTH.
Also determinations of smaller peptide hormones such as oxytocin in non-extracted serum, causes great difficulties, because the required sensitivity cannot be reached.
Although, in principle, the immunological crossreaction between HCG and LH enables both hormones to be determined with one test-system, most methods for the determination of human chorionic gonadotrophin (HCG) by a coupling product of HCG and an enzyme cannot be used for the demonstration and determination of luteinizing hormone (LH). This is due to the fact that LH occurs in much lower concentrations in blood and urine than HCG during pregnancy, so that the sensitivity of the test systems are insufficient. This shortage of sensitivity can be decreased by extracting the substance to be determined from the medium in which it occurs or by concentrating the medium. These methods, however, are very laborious, and the results often unsatisfactory.
A process has now been found for the demonstration and determination of a component of the reaction between specific binding proteins and the substances that can be specifically bound by these proteins, using the known binding affinity of such components for each other, which comprises reacting the component to be determined with its binding partner, which has been or is insolubilised, separating the solid phase of the reaction mixture from the liquid phase, reacting the solid phase with a coupling product, obtained by binding a substance capable of reacting specifically with one of the reaction components, to an enzyme, and finally determining the enzyme activity of the liquid or the solid phase in the reaction mixture obtained, which is a measure for the quantity of the substance to be determined.
The binding partner required for the determination of the component present in an unknown quantity, is employed in an insoluble form. The determination can take place by adding the binding partner to the reaction mixture in an insoluble form and reacting the mixture in a heterogeneous medium, but the binding partner can also be added in a dissolved form, after which it can be insolubilised by adding antisubstances against it.
The substance capable of reacting specifically with one of the reaction components, and which is employed coupled with an enzyme, may be the other reaction component, but also a third substance that must possess a specific affinity for one of the components of the reaction.
The method can be applied to the various reaction systems described above, i.e. antigen/antibody, hapten- /antibody and a low molecular substance/specific binding protein. As third substance a second antibody may occur, that is to say, an antibody against the gammaglobulin fraction of the species of animal in which the first antibodies have been generated. This situation may occur in the systems antigen/(first) antibody and hapten/(first) antibody. As third substance may also occur an antibody against a specific binding protein.
The essence of the method is the performance in two steps, in between which a separation takes place of the liquid and the solid phase of the reaction mixture. With the solid phase the second step is performed. Only in this stage the enzyme coupling product is employed and the enzyme activity determined.
The most important advantages of the method found are:
l. the first step can be performed in a larger volume than is desirable or possible for the second step. This is of great importance when the substance to be determined occurs in too low concentrations to be determined by known methods.
2. In the liquid to be examined substances may be present influencing the reactions in the second step unfavourably. Especially the enzyme present in the coupling product and the enzymatic catalysing reaction may be sensitive to disturbing substances in the test liquid.
The method found can especially be employed for the determination of substances present in body liquids such as hormones, their antibodies and specific binding proteins, as well as enzymes. Also factors of bloodclotting, fibrinolysis and complement systems, pathological proteins in body liquids, as well as antibodies against pathogenic microorganisms and iso-antibodies can be determined in this manner.
The medium in which the first step of the determination takes place often consists for a large part of test liquid, such as urine or serum. If considered necessary, it can be adjusted to the pH required for the immunochemical reaction, viz. between 5 and 9, by adding a dry buffer salt or a small volume of a concentrated buffer solution. The medium of the second step is also a buffer of a pH required for the immunochemical reaction. For this purpose phosphate buffers, citrate buffers, tris(hydroxy methyl)-aminomethane, and imidazole buffers can be employed. It may be necessary to use for the relative enzyme reaction a buffer of another composition and pH, which depends upon the enzyme employed.
The manufacture of the insolubilised reaction component can take place in various manners, i.a. dependent upon the properties of this reaction component. Thus, antibodies, specific binding proteins and proteinlike antigen can be insolubilised by cross-linking, for example, glutaric aldehyde and chloroformic acid ethyl ester, by physical adsorption or chemical coupling with an insoluble carrier, such as cellulose compounds, agarose, cross-linked dextran, polystyrene and the like, or by coupling with antibodies against the relative protein coupled with an insoluble carrier. Low molecular substances can be bound by methods dependent upon the structure of the low molecular substance and the carrier material. Some of the low molecular substances may already possess groups capable of reacting with the reactive parts on the carrier material: in other cases such groups will have to be introduced by organic chemical reactions.
The manufacture of the enzyme coupling products is also performed by methods dependent upon the properties of the molecules incorporated into the coupling product. A covalent bond of proteins to enzymes can be effected by reagents such as carbodiimides, diisocyanates, glutaric aldehyde and bis-diazobenzidine. The coupling of low molecular substances can take place in various manners. Some of these substances may already possess groups that can be cross-linked with reactive groups of the enzyme; in other cases such groups will have to be introduced by organic chemical reactions. It stands to reason that in the manufacture of these coupling products the original binding properties of the substances bound to the enzyme may not change very much; no more may the enzyme activity be decreased considerably.
The choice of the enzyme that is to form a part of the coupling product, is determined by properties such as the specific binding activity (a high conversion rate raises the sensitivity of the test system) and the simplicity of the determination of the enzyme. The determination of an enzyme catalysing a conversion in which coloured reaction components are involved, is simple. Such colorimetric determinations can be automated in a simple manner.
According to the invention it is also possible to employ enzymes catalysing those conversions in which reaction components are involved that can be determined spectrophotometrically or fluorimetrically. These determinations can also be automated.
In the manufacture of the coupling products enzymes such as catalase, peroxidase, B-glucuronidase, B-B- glucosidase, ,B-D-galactosidase, urease, glucoseoxidase and galactose-oxidase are preferred, especially the group of the oxidoreductases.
The determinations according to the invention are broadly performed as follows: A certain volume of a test liquid, for example 10 ml, containing a very low concentration of the component to be determined, is mixed with a certain quantity of an insolubilised reaction partner of the substance to be determined. The test liquid may be urine, in which the component to be determined occurs in low concentration, or serum, which has been diluted to diminish the influence of disturbing factors. In order to enable the reaction to be performed in the heterogeneous system, the mixture is agitated. The resulting solid phase is separated from the test liquid, for example by centrifugation, and washed, if considered necessary. The first part of the determination can also be performed by incubating the test liquid with a certain quantity of the reaction partner of the substance to be determined in a dissolved form, after which a quantity of insolubilised antibody against that reaction partner is added and the mixture agitated and finally centrifuged. Separation by filtration and decantation is also possible.
The second part of the determination is performed by resuspending the insoluble substance, which forms the The enzyme activity of a phase of the reaction mixture is demonstrated or measured by incubating that phase with a substrate and other substances required for the relative enzyme reaction.
Preferably a reaction is employed in which a coloured compound is formed, or removed, whose adsorption can be easily quantitatively determined.
The form in which the reagents can be used are manifold. The component of the reaction system coupled with an enzyme may have been dissolved in a buffer, or freeze-dried. Also a solid carrier can be used, for example a strip of paper impregnated with the enzyme coupling product.
The insoluble component can be processed in the form of particles of various sizes, such as grains, plates and rods, or in the form of a strip of some or other carrier material.
For the performance of the process according to the invention a test-pack is usually employed, chiefly consisting of:
a. a certain quantity of the enzyme coupling product;
b. a corresponding quantity of one of the components of the reaction system in an insoluble form;
c. a substrate for the determination of the quantity of the enzyme employed.
The test-pack can contain the necessary auxiliaries, if required, to make a dilution series of the sample to be tested for a quantitative determination, such as test tubes, pipettes and flasks containing a diluent. For the determination of antigens or haptens, or their antibodies, the test-pack contains at least:
a. a certain quantity of the coupling product of the antigen or hapten, or an antibody against it, and an enzyme;
b. a corresponding quantity of an insolubilised component of the reaction system antigen/antibody, or hapten/antibody, and
c. a substrate for the determination of the enzyme activity.
The invention is further illustrated by the following examples, which are on no account intended to limit the invention.
EXAMPLE I Determination of human chorionic gonadotrophin (HCG) in serum.
a. Preparation of HCG-HRP. Five mg of HCG and 20 mg of horse-radish peroxidase (HRP) were dissolved in 2 ml of 0.05 M phosphate buffer of pH 6.2. After 40 u/ltr of 25 percent glutaric aldehyde solution had been added, the mixture was shaken at room temperature for 2 hours. Then the mixture was centrifuged for 5 minutes at 250 g, after which it was fractionated over Sephadex G-200 in 0.05 M phosphate buffer of pH 6.2. The fractions whose highest percentage of enzyme activity was bound by antibodies against HCG, were used in the test system.
b. Preparation of antibodies against HCG. Antibodies against HCG were generated in rabbits as described by Schuurs et. al. in Acta Endocr. (Kbh.) 59, (1968).
c. Preparation of the immuno-adsorbent, anti-HCG- cellulose. The y-globulin fraction of the anti-HCG- serum described under 1)) was prepared by precipitation with 18 percent (w/v) solid Na SO The precipitate was washed and then taken up in so much 0.05 M borate buffer of pH 8.6 that the ultimate protein concentration was 10 mg/ml. M-aminobenzyloxy methyl cellulose (350 mg) prepared by Gurvichs method, described in Biokhimiya 26, 934 (1961 was suspended in 50 ml of distilled water and diazotized by adding 10 ml of 36 percent hydrochloric acid and, dropwise, 10 ml of 10 percent NaNo -solution. The suspension was centrifuged and washed, and the precipitate resuspended in 43 ml of 0.05 M sodium borate of pH 8.6. 'yglobulin solution prepared 7 ml were added to this suspension. The mixture was stirred for 26 hours at 4C, centrifuged, and finally washed with 1 ltr of 0.02 M phosphate buffer of pH W V p 7 d. 'otr'ni'ifififiafimofi serum. A dilution series of HCG (8-4-2-l-0.5-0.25-0 l.U./ml) was prepared with a dilution liquid consisting of one part of mans serum and 2 part of 0.05 M phosphate buffer of pH 6.2. Of each of the thus prepared HCG dilutions 0.5 ml was rotated for 2 hours at room temperature with 0.5 ml of the immuno-adsorbent suspension (4 mg/ml), prepared in accordance with c), and then centrifuged. The precipitate was washed twice, each time with 2 ml of 0.05 M phosphate buffer of pH 6.2. The precipitate was mixed with 1.0 ml of HCG-HRP solution in a suitable dilution, as well as in 0.05 M phosphate buffer of pH 6.2, and rotated again at room temperature for 2 hours.
After centrifugation the enzyme activity was determined in the supernatant liquid by adding 0.5 ml of it to 1.5 ml of a substrate solution consisting of 10 ul of 30% H 0 and 20 mg of 5-amino salicylic acid in ml of0.02 M phosphate buffer of pH 6.0. After 30 minutes the extinction was measured at 460 nm.
In the test system described a HCG concentration of 0.25 I.U./ml caused a measurable increase in the enzyme activity in the supernatant liquid, while a concentration of 1 I.U./ml caused the maximum increase. in this test the centrifugation step proved to be of decisive significance, as omission of this step gave rise to wrong measuring results of the enzyme activity, La. owing to turbidity of the serum and the peroxidase-like activity of it.
The HCG content of serum of pregnant women could be determined in this experimental set-up provided that the serum sample was diluted in the ratio of at least 1:3.
EXAMPLE II Determination of HCG in low concentrations by means of an enzyme/antigen coupling product.
a. Preparation of antisubstances against rabbit-yglobulin. Rabbit-y-globulin was isolated from normal rabbit serum by precipitating it with 18 percent (w/v) solid Na SO Antibodies against it were generated in a sheep. The injection scheme was:
Day Quantity Freunds adjuvant Manner of injection 0.5 mg lntramuscularly 14 0.5 mg Do.
28 1 mg Do.
42 1 mg Intravenously 56 1 mg Do.
On day 70 the sheep was exsanguinated.
b. Preparation of [sheep-anti-(rabbit-'y-globulin)]- cellulose. The 'y-globulin fraction of the sheep serum described under a) was prepared by precipitating it with 16 percent (w/v) solid sodium sulphate. This y-globulin fraction was bound to maminobenzyloxymethyl-cellulose, as described in example I c).
c. Determination of human chorionic gonadotrophin (HCG). A dilution series of HCG was prepared in 0.01 M phosphate buffer of pH 6.0, which also contained 2 percent (v/v) normal sheep serum. The dilution series was in the range of 10 to 320 I.U./ l, the dilution factor being 2. v
To 5 ml of a HCG solution was added 0.1 ml of a rabbit (anti-HCG) serum (see example I b), diluted with the same buffer to the desired strength. The mixture was left to stand at room temperature for 30 minutes, after which 1.5 mg of [sheep-anti(rabbit-y-globulin)] cellulose were added and the mixture was rotated for 2 hours.
The cellulose was centrifuged for minutes at 3,000 rpm. and resuspended in 1 ml of a solution of HCG- l-IRP coupling product, prepared in accordance with example I a), diluted to the desired strength with 0.01 M phosphate buffer of pH 6.0 with 2 percent normal sheep serum. The mixture was stirred again for 2 hours. After centrifugation the enzyme activity was determined in the supernatant liquid by adding 0.5 m] of it to 1.5 ml of enzyme substrate consisting of 10 pl of 30 percent H 0 and 20 mg of 5-amino-salicylic acid in 150 ml of 0.01 M phosphate buffer of pH 6.0. The mixture was left to stand for 30 minutes at 25, after which the extinction was measured at 460 nm. In the supernatant liquid 100 percent enzyme activity is measured provided that no anti-HCG serum is added to the system.
A dilution series of HCG, prepared with childrens urine as dilution liquid, gave an identical pattern so that also measurings in urine samples can be performed.
The centrifugation step effects a ten times higher sensitivity than can be reached in a system without centrifugation.
EXAMPLE III Determination of HCG and LH in low concentrations by means of an enzyme/antibody coupling product.
a. Preparation of the immune-adsorbent HCG cellulose. This immuno-adsorbent was prepared by the method mentioned in example I c), but instead of rabbit-y-globulin, 100 mg of HCG were coupled to 500 mg of m-aminobenzyloxymethyl cellulose.
b. Purification of antibodies against HCG. Ten ml of rabbit-anti-HCG serum, prepared in accordance with example I b), was diluted with 90 ml of 0.05 M citrate of pH 5.0 and slowly led over the immuno-adsorbent, which has packed in a column and mixed with 10 parts of Sephadex G-25. The immunoadsorbent was washed with the same buffer till no more protein was eluted. The antisubstances were eluted with 0.05 M citrate of pH 2.0. The fractions were collected in one half volume of 0.25 M NaHCO;,, tested for their content of antibodies and protein, and the suitable fractions were frozen.
c. Preparation of the coupling product (anti-HCG)- HRP. Twenty mg of horse radish peroxidase (HRP) were dissolved in 2 ml of an antibody solution having a protein content of 2 mg/ml. To this solution were added 8 pl of 25 percent glutaric aldehyde solution, after which the mixture was shaken for 2 hours at room temperature. Finally the mixture was fractionated over a Sephadex G-200 column in 0.05 M phosphate buffer of pH 6.5. The fractions whose highest percentage of enzyme activity were bound to HCG cellulose, were used in the test system.
d. Determination of HCG and LH. Ten ml of a HCG dilution series of HCG and 10 ml ofa HCG dilution series of LH were mixed with 5 mg of anti-HCG cellulose, prepared in accordance with example I c), which was suspended in 1 ml of 0.15 M phosphate buffer of pH 6.0, and the mixtures rotate at room temperature for 2 hours. The immunoadsorbent was centrifuged and washed with 5 ml of 0.05 M phosphate buffer of pH 6.0.
To the immuno-adsorbent 1 ml of the (anti-HCG)- HRP coupling product was added in the desired dilution, after which the mixture was rotated again for 2 hours. Finally, after centrifugation, the enzyme activity of the supernatant liquid was determined as described in the previous examples.
By this method a concentration of from 5 to 10 I.U. of HCG and 10 to 20 I.U. of LH per litre respectively could be determined. If the centrifugation step is omitted the optimum sample size is 0.5 nl and the sensitivity about I.U. of HCG per litre, or about 200 I.U. of LH per litre, so that the method according to the invention yields a 10-20 fold increase in sensitivity.
EXAMPLE IV Determination of HCG and anti-HCG.
a. Rabbit-serum was fractionated over DEAE cellulose in accordance with the prescription of H.A. Sober and others in J. Am. Chem. Soc. 78, 756 (1956). The isolated y-globulin fraction, which was immuno-electrophoretically pure, was partly used for generating antibodies in a sheep in accordance with the scheme of example [I a), while besides 100 mg of rabbit-y-globulin was coupled to 500 mg of m-aminobenzyloxymethyl cellulose by the method described in example I c).
From the sheep [anti-(rabbit-y-y-globulin)] serum prepared the specific antibodies were isolated by the method described in example II b) with the immune-adsorbent III b. The coupling product [anti-(rabbit-y-globulinH- HRP was prepared analogous to the coupling product (anti-HCG)-HRP, described in example lll c).
0. Determination of anti-HCG. A dilution series of rabbit-(anti-HCG) serum was prepared with 0.05 M phosphate buffer of pH 6.0.
Rabbit-(anti-HCG) serum (0.5 ml) was rotated with 0.25 mg of HCG-cellulose for 2 hours (see example 111 a). The reaction mixture was centrifuged and the precipitate washed four times with phosphate buffer, each time with 3 ml, after which the precipitate was resuspended in 1 ml of a solution of the coupling product b. The mixture obtained was again rotated for 2 hours. After centrifugation the enzyme activity in the supernatant liquid was determined, as described in example l d).
d. Determination of HCG. With the reagents prepared, HCG was determined by incubating solutions of it with 0.5 ml of rabbit-(anti-HCG)-serum in a dilution which in the system described under just causes an almost maximum reduction in enzyme activity in the supernatant liquid, and performing the process described under c) with the mixture obtained.
Where use was made of ml of HCG solution, it
proved to be possible to demonstrate concentrations of about 1.U./l of HCG.
EXAMPLE v Determination of insulin in serum.
a. Preparation of insulin-(glucose-oxidase). Five mg of hog insulin and 25 ml of glucose-oxidase were dissolved in 2 ml of 0.05 M phosphate buffer of pH 6.5. To this solution 5 'yl of 25 percent glutaraldehyde solution were added, after which the mixture was shaken at room temperature for 90 minutes. The mixture was fractionated over Sephadex G-200 in 0.05 M phosphate buffer of pH 6.5. The fractions whose highest percentage of enzyme ac tivity could be bound by antibodies against insulin were used in the test system.
b. Preparation of antibodies against insulin. Ten caviae were injected intramuscularly, once a week, with 1 mg of hog insulin in complete Freunds adjuvant, over a period of from 4 to 8 weeks. After having been left alone for 2 weeks the animals were injected intravenously with another milligram of insulin without adjuvant. Another 2 weeks later the animals were exsanguinated. Hypoglycemia occurring occasionally was combated by intraperitoneal administration of glucose.
c. Preparation of anti-substances against cavia 'y-globulin. Cavia -y-globulin was prepared by adding one volume of a saturated ammonium sulphate solution to two volumes of cavia serum. The resulting precipitate was washed twice with 33 percent saturated (NH S0 solution and then taken up in a physiological salt solution. A sheep was immunized with increasing dosages of the 'y-globulin prepared, viz. 0, 5, 1 and 2 mg. The injections were given every 2 weeks, the immunogen being mixed with complete Freunds adjuvant. Two weeks after the last injection another 2 mg of y-globulin, in a physiological salt solution, were given. One week later the animal was exsanguinated.
d. Preparation of insoluble antibodies against cavia 'y-globulin. Ten gm of microcrystalline cellulose were activated by adding it, while stirring, to 400 ml of 2.5 percent (w/v) CNBr solution, after which the pH was adjusted to 10.5 with an 1 N NaOH- solution, and it was maintained at it for 2 minutes. The cellulose was washed with ice water and with 0.1 M NaHCO;,. To 10 ml of sheep-anti-(cavia y-globulin) serum 1.6 gm of NaSO, were added. After stirring for 1 hour at room temperature the precipitate was centrifuged, washed twice with 20 ml of 16 percent (w/v) Na SO. solution, and finally taken up in 10 ml of 0.1 M NaHCO;,.
The activated cellulose was mixed with 40 ml ofa 0.1
M NaHCO;, solution and the 10 ml of y-globulin solution. This suspension was rotated for 40 hours at 4C and washed, twice with 5 ml of 0.5 M NaHCO twice with 500 ml of 0.05 M citrate of pH 1.1, and two times with 500 ml of 0.05 M phosphate of pH 6.2.
e. Determination of insulin in serum. Four ml of an insulin dilution series in the range of from O-lOO ng/ml, were incubated at room temperature, for 4 hours, with 1.0 ml ofanti-insulin serum (with 0.15 M phosphate buffer of pH 6.0, diluted to the desired strength). After that 5 mg of the immunoadsorbent prepared under a), suspended in 1 ml of 0.15 M phosphate buffer of pH 6.0, were added, and the resulting mixture rotated overnight at 4C. Then the immuno-adsorbent was centrifuged and washed three times with 5 ml of 0.05 M phosphate buffer of pH 6.0 (each time with 5 ml), to which 2 percent sheep serum had been added. After that 1.0 ml of insulin-glucose oxidase, diluted to the desired strength with the wash buffer, was added to the immunoadsorbent. The mixture obtained was again rotated overnight and centrifuged, after which the enzyme activity in the supernatant liquid was measured by incubating 0.5 ml of it with 2.5 ml of a substrate solution, and the extinction measured at 460 nm. The substrate solution contained mg of glucose, 10 ugm of peroxidase and 1 mg of S-aminosalicylic acid per 2.5 ml of 0.05 M phosphate buffer of pH 6.0.
The centrifugation step, in this case serving both to raise the maximum volume of the test liquid to be employed and to remove serum factors disturbing the reaction, caused a lO-fold increase in sensitivity, so that a concentration of a few ng/ml of insulin could be demonstrated.
EXAMPLE VI Determination of oestradiol.
a. Preparation of oestradiol-l7-succinyl-l-1RP. Fifty mg of oestradiol-l7-haemisuccinate and 0.08 ml of tri-n-butylamine were dissolved in 2.5 ml of diox ane. To the cold solution (2C) 15 u] of isobutylchlorocarbonate were added. After 30 minutes this solution was mixed with mg of horse radish peroxidase (HRP) in 7.5 ml of a mixture of dioxane and water (2:3), which had been adjusted to pH 9.5 with caustic soda. This solution was stirred for 4 hours at 2C, after which it was dialysed for 18 hours. The precipitate obtained after the pH of the dialysate had been adjusted to 4.6 was centrifuged, washed, and taken up in 5 ml of distilled water, which had been adjusted to pH 8. The material was purified further by precipitating it twice with 10 ml of acetone. The ultimate product was taken up in 10 ml of 0.05 M phosphate buffer of pH 7.8.
b. Preparation of oestradiol-l7-succinyl-BSA. The preparation was prepared by the mixed anhydride method as described under a). The starting material was 100 mg of oestradiol-l7-haemisuccinate and mg of bovine serum albumin (BSA).
0. Preparation of anti-substances against oestradiol. A sheep was injected every 4 weeks with 4 mg of oestradiol-l7-succinyl-BSA in complete Freunds adjavant. With regular intervals blood was taken from the sheep. The serum was adsorbed with BSA.
Day Quantity Freund's adjuvant Manner of injection 200 ugm lntramuscularly 14 400 ugm Do.
28 800 tgm Do.
42 800 agm lntravenously Two weeks after the last injection the animals were exsanguinated.
e. Preparation of the immuno-adsorbent [rabbitanti(-sheep-y-globulin)] cellulose.
The 'y-globulin fraction of the anti-sera described under 12) was prepared by precipitation with 18 percent w/v Na SO The product obtained was coupled with cellulose by Gurvichs method described in example I c).
f. Determination of oestradiol. A dilution series of oestradiol (00.5124-8l6 ng/ml) was prepared in phisphate buffer of pH 6.0. Five ml of sample were mixed with 0.5 ml of the sheep-antioestradiol-serum in the desired dilution. After incubating the mixture for 2 hours at room temperature 1 ml of immunoadsorbent suspension (see e) of 60 mg/ml was added, after which the mixture was rotated for 4 hours at room temperature. The cellulose was centrifuged and washed with 5 ml of 0.05 M phosphate buffer of pH 6.0 containing 2 percent BSA. Then 1 ml of oestradiol-17-succinyl- HRP, diluted to the desired strength with the buffer with which the mixture was washed, was added to the cellulose. The mixture was rotated for 1 hour, after which it was centrifuged again and the enzyme activity in the supernatant liquid was measured as described in example I.
By the method described concentrations of 1 ng/ml of oestradiol could be demonstrated, which means an increase in sensitivity by a factor 10, compared with the test without centrifugation step.
EXAMPLE Vll Determination of cortisol.
a. Preparation of cortisol-21-galactose-oxidase.
Fifty mg of cortisol-2l-haemisuccinate and 100 mg of galactose-oxidase were coupled by the mixed anhydride method as described in example VI a).
b. Preparation of insoluble transcortine. One hundred mg of transcortine purified by DEAE cellulose chromatography, followed by hydroxylapatite chromatography, were coupled with 3 gm of Sepharose 4B by the CNBr method: Sepharose 4B suspension (3 gm) was activated by mixing it with 4 ml of 2.5 percent (w/v) CNBr-solution in distilled water, after which the pH was adjusted to 1 N NaOH between 10 and 11, at which value it was maintained for 6 minutes. Then the Sepharose was washed with ice-water and with 0.1 M NaHCO;,, after which mg of transcortine in 20 ml 0g 0.1 M NaHCO:, were added, and the suspension was shaken at 4C for 24 hours, After being washed successively with 0.5 M NaHCO;,, 0.05 M citrate buffer of pH 1.1 and 0.05 M phosphate buffer of pH 6.0, the Sepharose was kept in the last buffer, to which 0.1 percent merthiolate had been added.
0. Determination of cortisol. A cortisol dilution series, in the range of from 0.25-16 ng/ml was prepared in 0.05 M phosphate buffer of pH 6.0. File ml of each cortisol solution (in 0.5 M phosphate buffer of pH 6.0) were rotated overnight with 5 mg of transcortine-Sepharose, at 4C. After centrifugation 1 ml of cortisol-2l-galactose oxidase solution, diluted to a suitable concentration in the buffer mentioned before, was added, after which the mixture was rotated for 2 hours at 4C. After recentrifugation the enzyme activity in the supernatant liquid was determined by adding 0.5 ml of it to 1.5 ml of substrate constisting of 100 mg of D- galactose, 20 mg of S-amino-salicylic acid and 10 ugm of peroxidase in ml of 0.02 M phosphate buffer of pH 6.0. Finally, after 30 minutes, the extinction was measured at 460 nm.
By this method about 1 ng/ml cortisol could be demonstrated, which means an increase in sensitivity by a factor 10.
We claim:
1. Process for the demonstration and determination of a component of the reaction between a bindable substance selected from the group consisting of an antigen, a hapten, and a low molecular substance, and a protein capable of binding said bindable substance specifically, said protein being selected from the group consisting of an antibody and a specific binding protein, comprising the steps of:
a. providing a given quantity of the binding partner of the component to be determined, which binding partner is in an insoluble form;
b. reacting the component to be determined with its binding partner to form a reaction mixture having a solid phase and a liquid phase;
c. separating the solid phase from the liquid phase;
d. adding to said solid phase a given quantity of a coupling product of the component to be determined with an enzyme; and
e. determining the enzyme activity of the solid phase which is a measure of the quantity of reaction component to be determined.
2. Process for the demonstration and determination of a component of the reaction between a bindable substance selected from the group consisting of an antigen, a hapten, and a low molecular substance, and a protein capable of binding said bindable substance specifically, said protein being selected from the group consisting of an antibody and a specific binding protein, comprising the steps of:
a. providing a given quantity of the binding partner of the component to be determined in a soluble form;
b. adding a given quantity of an antibody against said binding partner, which antibody is in an insoluble 14 sure of the quantity of the reaction component to be determined.
3. The process of claim 1 in which the enzyme is an oxido-reductase.
4. The process of claim 2 in which the enzyme is an oxido-reductase.
Claims (3)
- 2. Process for the demonstration and determination of a component of the reaction between a bindable substance selected from the group consisting of an antigen, a hapten, and a low molecular substance, and a protein capable of binding said bindable substance specifically, said protein being selected from the group consisting of an antibody and a specific binding protein, comprising the steps of: a. providing a given quantity of the binding partner of the component to be determined in a soluble form; b. adding a given quantity of an antibody against said binding partner, which antibody is in an insoluble form, to form a reaction mixture having a solid phase and a liquid phase; c. separating the solid phase from the liquid phase; d. adding to said solid phase a given quantity of a coupling product of the component to be determined with an enzyme; and e. determining the enzyme activity of either the liquid phase or the solid phase, which activity is a measure of the quantity of the reaction component to be determined.
- 3. The process of claim 1 in which the enzyme is an oxido-reductase.
- 4. The process of claim 2 in which the enzyme is an oxido-reductase.
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NL717101728A NL154600B (en) | 1971-02-10 | 1971-02-10 | METHOD FOR THE DETERMINATION AND DETERMINATION OF SPECIFIC BINDING PROTEINS AND THEIR CORRESPONDING BINDABLE SUBSTANCES. |
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US4318707A (en) * | 1978-11-24 | 1982-03-09 | Syva Company | Macromolecular fluorescent quencher particle in specific receptor assays |
US4323647A (en) * | 1980-10-15 | 1982-04-06 | University Of Miami | Steric hindrance enzyme immunoassay |
US4331444A (en) * | 1979-03-01 | 1982-05-25 | Fuji Photo Film Co., Ltd. | Competitive immunoassay using silver halide fogging agent |
US4337063A (en) * | 1979-03-01 | 1982-06-29 | Fuji Photo Film Co., Ltd. | Competitive immunoassay using spectral sensitizer label |
USRE31006E (en) * | 1968-09-24 | 1982-08-03 | Akzona Incorporated | Process for the demonstration and determination of reaction components having specific binding affinity for each other |
WO1982002601A1 (en) * | 1981-01-23 | 1982-08-05 | Hospital Supply Corp American | Solid phase system for ligand assay |
US4343896A (en) * | 1975-02-01 | 1982-08-10 | Akzona Incorporated | Method and test pack for the demonstration and determination of an antigen or antibody |
EP0060700A1 (en) * | 1981-03-13 | 1982-09-22 | Immuno-Mycologics, Inc. | Assay method and device |
US4362531A (en) * | 1980-04-15 | 1982-12-07 | Technicon Instruments Corporation | Agglutination immunoassays carried out with agent to reduce non-specific interferences |
US4374925A (en) * | 1978-11-24 | 1983-02-22 | Syva Company | Macromolecular environment control in specific receptor assays |
US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
WO1983000877A1 (en) * | 1981-08-31 | 1983-03-17 | Icl Scient | Glucose oxidase immunohistochemical detection of antinuclear antibodies |
US4446238A (en) * | 1981-03-19 | 1984-05-01 | Janssen Pharmaceutica N.V. | Bright field light microscopic method of localizing tissue antigens |
US4446232A (en) * | 1981-10-13 | 1984-05-01 | Liotta Lance A | Enzyme immunoassay with two-zoned device having bound antigens |
US4452886A (en) * | 1981-09-21 | 1984-06-05 | Henry Robert P | Novel photon absorbing or emitting polymers and their use as reagents in immunoassay systems |
US4469787A (en) * | 1982-05-14 | 1984-09-04 | Mallinckrodt Inc. | Immunoassay involving soluble complex of second antibody and labeled binding protein |
US4474878A (en) * | 1975-09-29 | 1984-10-02 | Cordis Laboratories, Inc. | Sandwich EIA for antigen associated with hepatitis |
US4486530A (en) * | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
US4503143A (en) * | 1982-08-20 | 1985-03-05 | Btc Diagnostics Limited Partnership | Enzyme immunoassay with two-part solution of tetramethylbenzidine as chromogen |
US4506009A (en) * | 1982-03-30 | 1985-03-19 | University Of California | Heterogeneous immunoassay method |
WO1985002260A1 (en) * | 1983-11-08 | 1985-05-23 | Quidel | Rapid plunger immunoassay method and apparatus |
US4530900A (en) * | 1982-09-13 | 1985-07-23 | Seragen Diagnostics Inc. | Soluble insoluble polymers in enzymeimmunoassay |
WO1985003950A1 (en) * | 1984-03-08 | 1985-09-12 | Scripps Clinic And Research Foundation | A sv40 expression vector containing hbxag as an expression marker |
WO1985004397A1 (en) | 1984-03-23 | 1985-10-10 | Oncogen | Platelet related growth regulator |
US4592995A (en) * | 1981-03-30 | 1986-06-03 | Dainippon Pharmaceutical Co., Ltd. | Reagent for streptococcal anti-esterase assay |
US4604365A (en) * | 1981-06-02 | 1986-08-05 | Electro-Nucleonics, Inc. | Immunoprecipitation assay |
US4642285A (en) * | 1975-09-29 | 1987-02-10 | Diamedix Corporation | Sandwich EIA for antigen |
US4665020A (en) * | 1984-05-30 | 1987-05-12 | United States Department Of Energy | Flow cytometer measurement of binding assays |
US4713347A (en) * | 1985-01-14 | 1987-12-15 | Sensor Diagnostics, Inc. | Measurement of ligand/anti-ligand interactions using bulk conductance |
USRE32696E (en) * | 1975-09-04 | 1988-06-14 | Akzona Incorporated | Enzymatic immunological method for determination of antigens and antibodies |
US4753875A (en) * | 1981-11-02 | 1988-06-28 | Ryan James W | Method for assaying proteases with tagged proteinaceous inhibitors |
US4808522A (en) * | 1986-04-24 | 1989-02-28 | Moskovsky Gosudarstvennx Universitet Imeni M. V. Lomonoso VA | Enzyme immunoassays using inorganic pyrophosphatase |
US4812395A (en) * | 1984-11-05 | 1989-03-14 | E. I. Du Pont De Nemours And Company | Method for detecting enzymatic activity using particle agglutination |
US4812396A (en) * | 1984-11-05 | 1989-03-14 | E. I. Du Pont De Nemours And Company | Method for detecting enzymatic activity using particle agglutination |
US4824784A (en) * | 1985-04-08 | 1989-04-25 | Hygeia Sciences, Incorporated | Chromogenic solution for immunoassay |
US4868108A (en) * | 1985-12-12 | 1989-09-19 | Hygeia Sciences, Incorporated | Multiple-antibody detection of antigen |
US4931385A (en) * | 1985-06-24 | 1990-06-05 | Hygeia Sciences, Incorporated | Enzyme immunoassays and immunologic reagents |
US5047330A (en) * | 1983-08-17 | 1991-09-10 | Commissariat A L'energie Atomique | Compound labelled by the acetyl cholinesterase of Electrophorus electricus, its preparation process and its use as a tracer or marker in enzymoimmunological determinations |
US5102788A (en) * | 1988-11-21 | 1992-04-07 | Hygeia Sciences, Inc. | Immunoassay including lyophilized reactant mixture |
US5328828A (en) * | 1988-12-23 | 1994-07-12 | Syntex (U.S.A.) Inc. | Compositions and methods for determining the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine |
US5334513A (en) * | 1988-05-17 | 1994-08-02 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
US5348867A (en) * | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
US5468647A (en) * | 1988-05-17 | 1995-11-21 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
WO1997005886A1 (en) * | 1995-08-04 | 1997-02-20 | Board Of Regents, The University Of Texas System | Compositions for conferring immunogenicity to a peptide |
US5610077A (en) * | 1980-06-20 | 1997-03-11 | Unilever Patent Holdings B.V. | Processes and apparatus for carrying out specific binding assays |
US5614504A (en) * | 1990-08-01 | 1997-03-25 | The University Of South Florida | Method of making inosine monophosphate derivatives and immunopotentiating uses thereof |
US5672475A (en) * | 1993-05-06 | 1997-09-30 | Chiron Diagnostics Corporation | Mixed luminescent conjugate test |
US5698686A (en) * | 1994-10-20 | 1997-12-16 | Arch Development Corporation | Yeast telomerase compositions |
US5726015A (en) * | 1991-05-15 | 1998-03-10 | Vanderbilt University | Method to determine metastatic potential of tumor cells |
US5726023A (en) * | 1993-03-17 | 1998-03-10 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated |
US5728807A (en) * | 1995-05-16 | 1998-03-17 | Ramot-University Authority For Applied Research And Industrial Development, Ltd. | Mutated proteins associated with ataxia-telangiectasia |
US5777093A (en) * | 1995-05-16 | 1998-07-07 | Ramot-University Authority For Applied Research & Industrial Development Ltd. | cDNAs associated with ataxia-telangiectasia |
US5837535A (en) * | 1994-06-13 | 1998-11-17 | Henry Ford Health System | Neuronal-neonatal gene: neuronatin |
US5840322A (en) * | 1996-12-19 | 1998-11-24 | Ramot-University Authority For Applied Research & Industrial Devel. Ltd. | Anti-oral-microbial adhesion fraction derived from vaccinium |
US5843673A (en) * | 1994-10-25 | 1998-12-01 | Curators Of The University Of Missouri | Method of screening for endometriosis |
US5858661A (en) * | 1995-05-16 | 1999-01-12 | Ramot-University Authority For Applied Research And Industrial Development | Ataxia-telangiectasia gene and its genomic organization |
US5869445A (en) * | 1993-03-17 | 1999-02-09 | University Of Washington | Methods for eliciting or enhancing reactivity to HER-2/neu protein |
US5874423A (en) * | 1992-09-10 | 1999-02-23 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Digitalis-like compounds |
US6187563B1 (en) | 1998-08-07 | 2001-02-13 | Yale University | βIV-spectrin-polypeptides and nucleic acids encoding same |
US6284496B1 (en) | 1997-10-03 | 2001-09-04 | University Of South Florida | DNA vector for determining the presence of out-of-reading-frame mutations |
US6312901B2 (en) | 1996-07-08 | 2001-11-06 | Burstein Technologies, Inc. | Spatially addressable, cleavable reflective signal elements, assay device and method |
US6331275B1 (en) | 1996-07-08 | 2001-12-18 | Burstein Technologies, Inc. | Spatially addressable, cleavable reflective signal elements, assay device and method |
US6342349B1 (en) | 1996-07-08 | 2002-01-29 | Burstein Technologies, Inc. | Optical disk-based assay devices and methods |
US6344443B1 (en) | 1998-07-08 | 2002-02-05 | University Of South Florida | Peptide antagonists of tumor necrosis factor alpha |
US6391563B1 (en) | 1980-07-28 | 2002-05-21 | Akzo Nobel N.V. | Method for the determination of antigens with the aid of three or more monoclonal antibodies |
WO2002044736A2 (en) | 2000-11-30 | 2002-06-06 | Molecular Skincare Limited | Diagnosis and treatment of epidermal or skin diseases |
US6406920B1 (en) | 1980-06-20 | 2002-06-18 | Inverness Medical Switzerland Gmbh | Processes and apparatus for carrying out specific binding assays |
US20020106661A1 (en) * | 1996-07-08 | 2002-08-08 | Burstein Laboratories, Inc. | Optical disk-based assay devices and methods |
US6440682B1 (en) * | 1999-05-28 | 2002-08-27 | Detroit R&D Inc. | Detection of hypertension using immunoreactive metabolic products |
US20020142287A1 (en) * | 2000-12-14 | 2002-10-03 | Hirotaka Yamamoto | High throughput assay to detect inhibitors of the map kinase pathway |
US6482389B1 (en) | 1997-10-17 | 2002-11-19 | University Of South Florida | Method to diagnose and monitor cellular immune deficiencies |
US20020172980A1 (en) * | 2000-11-27 | 2002-11-21 | Phan Brigitte Chau | Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems |
US20030003464A1 (en) * | 2000-11-27 | 2003-01-02 | Phan Brigitte C. | Dual bead assays including optical biodiscs and methods relating thereto |
US6531277B2 (en) | 1994-10-25 | 2003-03-11 | The Curators Of The University Of Missouri | Endometriosis-specific secretory protein |
US20030064058A1 (en) * | 2001-09-07 | 2003-04-03 | Nadir Askenasy | Methods of utilizing bone marrow stem cells for inducing immunological tolerance |
US20030086914A1 (en) * | 1999-06-25 | 2003-05-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method and device for inducing biological processes by micro-organs |
WO2003046201A2 (en) | 2001-11-21 | 2003-06-05 | Kimberly-Clark Worldwide, Inc. | Detection and identification of enteric bacteria |
US20030104491A1 (en) * | 2000-04-30 | 2003-06-05 | Cabantchik Ioav Zvi | Molecules and methods using same for measuring non-transferrin bound iron |
US20030114410A1 (en) * | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
US20030124116A1 (en) * | 1997-08-21 | 2003-07-03 | Quark Biotech, Inc. | Hypoxia-regulated genes |
US20030152909A1 (en) * | 1994-11-16 | 2003-08-14 | Mitrani Eduardo N. | In vitro micro-organs, and uses related thereto |
US6610838B1 (en) | 1997-09-10 | 2003-08-26 | Symbicom Aktiebolag | P13 antigens from Borrelia |
US20030211490A1 (en) * | 2000-01-24 | 2003-11-13 | Hanan Stein | Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby |
US6656471B1 (en) | 1998-11-17 | 2003-12-02 | Board Of Regents, The University Of Texas System | HIV-specific T-cell induction |
US6689757B1 (en) | 1996-02-12 | 2004-02-10 | M.L. Laboratories Plc | Methods for vaccination and vaccines therefor |
WO2004018698A2 (en) | 2002-08-20 | 2004-03-04 | Genitrix, Llc | Lectin compositions and methods for modulating an immune response to an antigen |
US20040052769A1 (en) * | 2000-11-30 | 2004-03-18 | Yair Reisner | Methods of utilizing cultured non-gvhd inducing t lymphocytes to treat disease |
US20040076976A1 (en) * | 2000-11-02 | 2004-04-22 | Pan Shen Quan | Aopb gene, protein,homologs, fragments and variants thereof, and their use for cell surface display |
US20040121442A1 (en) * | 2002-05-05 | 2004-06-24 | Ilan Chet | Fungal chitinase, polynucleotide sequences encoding same, promoters of same, and uses thereof |
WO2004060135A2 (en) | 2003-01-02 | 2004-07-22 | Rappaport Family Institute For Research In The Medical Sciences | Methods of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients |
US20040146949A1 (en) * | 2002-10-25 | 2004-07-29 | Jun Tan | Methods and compounds for disruption of CD40R/CD40L signaling in the treatment of alzheimer's disease |
US6770622B2 (en) | 2001-06-08 | 2004-08-03 | Gary A. Jarvis | N-terminally truncated galectin-3 for use in treating cancer |
US6787318B1 (en) | 1999-06-01 | 2004-09-07 | Roskamp Research Institute, Llc | Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology |
US20040197334A1 (en) * | 2003-04-02 | 2004-10-07 | Technion Research & Development Foundation Ltd. | Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same |
US20040248093A1 (en) * | 2000-11-27 | 2004-12-09 | Coombs James Howard | Magneto-optical bio-discs and systems including related methods |
US20050002953A1 (en) * | 2003-05-06 | 2005-01-06 | Jens Herold | SARS-coronavirus virus-like particles and methods of use |
US20050008624A1 (en) * | 2002-01-24 | 2005-01-13 | Tony Peled | Expansion of renewable stem cell populations |
US20050020499A1 (en) * | 2003-05-27 | 2005-01-27 | Bar Ilan University | Methods of attenuating cocaine seeking behavior employing glial cell-derived neurotrophic factor (GDNF) and pharmaceutical compositions and articles of manufacture suited for use in practice of the method |
US20050022269A1 (en) * | 2001-07-19 | 2005-01-27 | Joseph Hirschberg | Polypeptides having carotenoids isomerase catalytic activity, nucleic acids encoding same and uses thereof |
US20050032126A1 (en) * | 2003-03-03 | 2005-02-10 | Coombs James H. | Methods and apparatus for use in detection and quantitation of various cell types and use of optical bio-disc for performing same |
US20050031618A1 (en) * | 2001-01-31 | 2005-02-10 | Dror Mevorach | Induction of tolerance by apoptotic and/or necrotic cells |
US20050054103A1 (en) * | 2003-03-07 | 2005-03-10 | Tony Peled | Expansion of renewable stem cell populations using modulators of PI 3-kinase |
US20050054097A1 (en) * | 2002-11-17 | 2005-03-10 | Tony Peled | EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures |
US6867005B2 (en) | 2001-10-24 | 2005-03-15 | Beckman Coulter, Inc. | Method and apparatus for increasing the dynamic range and accuracy of binding assays |
US20050069923A1 (en) * | 1996-07-08 | 2005-03-31 | Mullis Kary Banks | Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus |
US6875582B1 (en) | 1999-08-19 | 2005-04-05 | Omniscience Pharmaceuticals, Inc. | Methods and targets of antibiotic resistance |
WO2005033145A1 (en) | 2003-10-07 | 2005-04-14 | Yeda Research And Development Co. Ltd. | Antibodies to nik, their preparation and use |
WO2005033142A2 (en) | 2003-10-07 | 2005-04-14 | Yeda Research And Development Co. Ltd. | Anti-nik antibodies and uses thereof |
US20050085432A1 (en) * | 2001-12-26 | 2005-04-21 | Aviva Lapidot | Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections |
US20050113327A1 (en) * | 1999-08-30 | 2005-05-26 | Levava Roiz | Methods of and compositions for inhibiting the proliferation of mammalian cells |
WO2005051423A2 (en) | 2003-11-30 | 2005-06-09 | Yeda Research And Development Co. Ltd | Methods and agents for immune modulation and methods for identifying immune modulators |
US20050152912A1 (en) * | 2003-03-26 | 2005-07-14 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US20050158809A1 (en) * | 2002-04-16 | 2005-07-21 | The Regents Of The University Of Califorina | Methods of renal cell carcinoma prognosis and treatment selection with carbonic anhydrase IX |
US20050158822A1 (en) * | 2004-01-20 | 2005-07-21 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5'-UTR |
US20050176143A1 (en) * | 1999-02-04 | 2005-08-11 | Technion Research & Development | Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells |
US20050191285A1 (en) * | 1993-03-17 | 2005-09-01 | University Of Washington | Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated |
US20050202098A1 (en) * | 2001-01-31 | 2005-09-15 | Tolaren | Disease therapy using dying or dead cells |
US20050214827A1 (en) * | 1996-07-08 | 2005-09-29 | Burstein Technologies, Inc. | Assay device and method |
US20050220774A1 (en) * | 2002-03-18 | 2005-10-06 | Tony Peled | Methods of inducing differentiation in ex vivo expanded stem cells |
US20050255101A1 (en) * | 2002-02-13 | 2005-11-17 | Technion Research And Development Foundation Ltd. | Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
US20050271643A1 (en) * | 2003-08-14 | 2005-12-08 | Iryna Sorokulova | Bacterial strains, compositions including same and probiotic use thereof |
US20060008479A1 (en) * | 1996-04-01 | 2006-01-12 | University Of Washington | Methods and compositions to generate immunity in humans against self tumor antigens by immunization with homologous foreign proteins |
US20060019340A1 (en) * | 1999-06-08 | 2006-01-26 | David Naor | CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases |
US6998232B1 (en) | 1999-09-27 | 2006-02-14 | Quark Biotech, Inc. | Methods of diagnosing bladder cancer |
US20060035980A1 (en) * | 2003-04-18 | 2006-02-16 | Scanlan Thomas S | Thyronamine derivatives and analogs and methods of use thereof |
US20060039897A1 (en) * | 2002-03-26 | 2006-02-23 | Tamar Lotan | Stinging cells expressing an exogenous polycleotide encoding a therpeutic, diagnostics or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derive therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue |
US20060051426A1 (en) * | 2001-12-05 | 2006-03-09 | Gershon Golomb | Nanoparticles containing polymeric nucleic acid homologs pharmaceutical composition and articles of manufacture containing same and methods of use thereof |
US20060079941A1 (en) * | 2004-10-12 | 2006-04-13 | Eli Ovsyshcher | Methods and implantable devices for treating supraventricular arrhythmias |
US7033747B2 (en) | 2001-04-11 | 2006-04-25 | Nagaoka & Co., Ltd | Multi-parameter assays including analysis discs and methods relating thereto |
US20060095241A1 (en) * | 2004-10-29 | 2006-05-04 | Microsoft Corporation | Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails |
US20060099273A1 (en) * | 2000-09-28 | 2006-05-11 | Nanocyte Inc. | Sterile preparations and compositions including stinging capsules and methods of producing and using same |
US20060123516A1 (en) * | 2003-05-22 | 2006-06-08 | Gil Ronen | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
US20060127366A1 (en) * | 1999-06-25 | 2006-06-15 | Mitrani Eduardo N | Method and device for inducing biological processes by micro-organs |
US20060134680A1 (en) * | 2004-12-22 | 2006-06-22 | Alexander Kotlyar | Homogeneous populations of nucleic acids, methods of synthesyzing same and uses thereof |
US20060148078A1 (en) * | 2002-11-29 | 2006-07-06 | Sharon Gerecht-Nir | Method of dynamically culturing embryonic stem cells |
US20060159769A1 (en) * | 2000-09-28 | 2006-07-20 | Nanocyte Inc. | Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue |
EP1683874A2 (en) | 2000-08-29 | 2006-07-26 | YEDA RESEARCH AND DEVELOPMENT Co. LTD. | Methods of isolating genes encoding proteins of specific function and of screening for pharmaceutically active agents |
US7087395B1 (en) | 2001-01-16 | 2006-08-08 | Quest Diagnostics Investments Incorporated | Vitamin D assay |
WO2006090388A2 (en) | 2005-02-25 | 2006-08-31 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center | Fruit cell culture extract for treating inflammation |
US7101839B1 (en) | 1999-08-30 | 2006-09-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of and compositions for inhibiting the proliferation of mammalian cells |
US20060211064A1 (en) * | 2005-03-18 | 2006-09-21 | Hyesook Kim | Detection of hypertension using glucuronidated metabolic products |
US20060234203A1 (en) * | 2005-04-19 | 2006-10-19 | Nanocyte Inc. | Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent |
US20060234947A1 (en) * | 2002-01-31 | 2006-10-19 | Tel Aviv University Future Technology Development L.P | Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases |
US20060257865A1 (en) * | 2001-10-23 | 2006-11-16 | Simon Mallal | Method for identification and development of therapeutic agents |
US20060260002A1 (en) * | 2003-06-19 | 2006-11-16 | Gil Ronen | Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same |
US20060257429A1 (en) * | 2003-10-23 | 2006-11-16 | Dreier Kimberly J | Vaccine for periodontal disease |
US20060278093A1 (en) * | 2004-01-13 | 2006-12-14 | Eytan Biderman | Feeding formula appliance |
WO2006134602A2 (en) | 2005-06-16 | 2006-12-21 | Ramot At Tel Aviv University Ltd. | Isolated cells and populations comprising same for the treatment of cns diseases |
US20060292559A1 (en) * | 2005-06-23 | 2006-12-28 | Beckman Coulter, Inc. | Cell-based microarrays, and methods for their preparation and use |
US20070032421A1 (en) * | 2003-12-12 | 2007-02-08 | Efrat Levy | Methods and compositions relating to cystatin C |
WO2007020638A2 (en) | 2005-08-15 | 2007-02-22 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
WO2007023491A2 (en) | 2005-08-24 | 2007-03-01 | Yeda Research And Development Co. Ltd. | Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance |
WO2007031996A1 (en) | 2005-09-12 | 2007-03-22 | Rappaport Family Institute For Research In The Medical Sciences | Compositions and methods for diagnosing and treating an inflammation |
WO2007034487A1 (en) | 2005-09-22 | 2007-03-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer |
US20070077652A1 (en) * | 2004-09-16 | 2007-04-05 | Tony Peled | Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells |
US20070087437A1 (en) * | 2005-10-14 | 2007-04-19 | Jifan Hu | Methods for rejuvenating cells in vitro and in vivo |
US7223902B1 (en) | 1999-11-19 | 2007-05-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of producing recombinant Aspergillus niger β-glucosidase and an aroma spreading plant |
US20070160546A1 (en) * | 2000-09-28 | 2007-07-12 | Tamar Lotan | Use of stinging cells/capsules for the delivery of active agents to keratinous substances |
US20070184530A1 (en) * | 2006-02-03 | 2007-08-09 | Fuad Fares | Long-acting veterinary polypeptides and methods of producing and administering same |
WO2007091254A1 (en) | 2006-02-06 | 2007-08-16 | Rappaport Family Institute For Research In The Medical Sciences | Methods and kit for diagnosing t1dm |
US20070196369A1 (en) * | 2002-02-20 | 2007-08-23 | Hoogenboom Henricus Renerus J | MHC-peptide complex binding ligands |
US7270810B2 (en) | 2000-01-05 | 2007-09-18 | Yeda Research And Development Co. Ltd. | Veto cells effective in preventing graft rejection and devoid of graft versus host potential |
US20070225242A1 (en) * | 2005-06-21 | 2007-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method and composition for treating and preventing tumor metastasis in vivo |
WO2007110869A2 (en) | 2006-03-28 | 2007-10-04 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods and kits for determining predisposition to warfarin resistance |
WO2007124299A2 (en) | 2006-04-21 | 2007-11-01 | Novartis Ag | Antagonist anti-cd40 antibody pharmaceutical compositions |
US20070281883A1 (en) * | 2006-06-05 | 2007-12-06 | Hanna Rosenfeld | Development of follicle stimulating hormone agonists and antagonists in fish |
US20080004234A1 (en) * | 2004-07-06 | 2008-01-03 | Segev Laboratories Limited | System for delivering therapeutic agents into living cells and cells nuclei |
WO2008010228A2 (en) | 2006-07-20 | 2008-01-24 | Yeda Research And Development Co. Ltd. | Photosyntheticorganisms and compositions and methods of generating same |
WO2008026198A2 (en) | 2006-08-28 | 2008-03-06 | Yeda Research And Development Co. Ltd. | Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns |
US7347972B1 (en) | 1998-07-22 | 2008-03-25 | Jin Po Lee | Multiple analyte assay device |
US20080082678A1 (en) * | 2005-01-16 | 2008-04-03 | Zlango Ltd. | Communications Network System and Methods for Using Same |
WO2008041183A2 (en) | 2006-10-05 | 2008-04-10 | Technion Research & Development Foundation Ltd. | Microtubes and methods of producing same |
US20080131419A1 (en) * | 2004-09-29 | 2008-06-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Recombinant Human T2 Rnase and Uses Thereof |
US20080138840A1 (en) * | 2006-09-08 | 2008-06-12 | Collins Michael T | Assay for antibodies to mycobacterium paratuberculosis |
WO2008084410A2 (en) | 2007-01-04 | 2008-07-17 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
WO2008093341A2 (en) | 2007-01-31 | 2008-08-07 | Technion Research & Development Foundation Ltd. | Electrospun scaffolds and methods of generating and using same |
WO2008093342A2 (en) | 2007-02-01 | 2008-08-07 | Technion Research & Development Foundation Ltd. | Albumin fibers and fabrics and methods of generating and using same |
WO2008097870A2 (en) | 2007-02-02 | 2008-08-14 | Baylor Research Institute | Agents that engage antigen - presenting cells through dendritic cell asialoglycoprotein receptor (dc- asgpr) |
US20080199895A1 (en) * | 2006-10-05 | 2008-08-21 | Yeda Research And Development Co. Ltd. | Highly purified and stabilized Na,K-ATPase isoforms and methods of producing same |
US20080216022A1 (en) * | 2005-01-16 | 2008-09-04 | Zlango Ltd. | Iconic Communication |
US20080233140A1 (en) * | 2007-02-23 | 2008-09-25 | Baylor Research Institute | Therapeutic Applications of Activation of Human Antigen-Presenting Cells Through Dectin-1 |
US20080241170A1 (en) * | 2007-02-02 | 2008-10-02 | Baylor Research Institute | Vaccines Based on Targeting Antigen to DCIR Expressed on Antigen-Presenting Cells |
WO2008120216A1 (en) | 2007-04-02 | 2008-10-09 | Ramot At Tel Aviv University Ltd. | Methods of detecting cancer cells and use of same for diagnosing and monitoring treatment of the disease |
WO2008120202A2 (en) | 2007-03-29 | 2008-10-09 | Technion Research & Development Foundation Ltd. | Antibodies, methods and kits for diagnosing and treating melanoma |
US20080254047A1 (en) * | 2007-02-23 | 2008-10-16 | Baylor Research Institute | Activation of Human Antigen-Presenting Cells Through CLEC-6 |
US20080254044A1 (en) * | 2007-02-02 | 2008-10-16 | Baylor Research Institute | Multivariable Antigens Complexed with Targeting Humanized Monoclonal Antibody |
US7442781B2 (en) | 2001-08-16 | 2008-10-28 | Urifer Ltd. | Diagnosis, prevention and treatment of cancer |
US20080267984A1 (en) * | 2007-02-23 | 2008-10-30 | Baylor Research Institute | Activation of Human Antigen-Presenting Cells Through Dendritic Cell Lectin-Like Oxidized LDL Receptor-1 (LOX-1) |
WO2008132753A2 (en) | 2007-05-01 | 2008-11-06 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods and kits for detecting fetal cells in the maternal blood |
US20080279828A1 (en) * | 2002-01-25 | 2008-11-13 | Tony Peled | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
US20090004158A1 (en) * | 1998-02-17 | 2009-01-01 | Tony Peled | Methods of controlling proliferation and differentiation of stem and progenitor cells |
US20090013087A1 (en) * | 2005-01-18 | 2009-01-08 | Zlango Ltd. | Communications Network System and Methods For Using Same |
WO2009010968A2 (en) | 2007-07-15 | 2009-01-22 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
US20090053224A1 (en) * | 2007-08-02 | 2009-02-26 | Arresto Biosciences | Lox and loxl2 inhibitors and uses thereof |
US20090068207A1 (en) * | 2005-04-15 | 2009-03-12 | Vascular Biogenics Ltd. | Compositions Containing Beta 2-Glycoprotein I-Derived Peptides for the Prevention and/or Treatment of Vascular Disease |
US20090068669A1 (en) * | 2007-09-12 | 2009-03-12 | Elias Georges | Slc9a3r1 directed diagnostics for neoplastic disease |
WO2009034574A2 (en) | 2007-09-12 | 2009-03-19 | Yeda Research And Development Co. Ltd. | Methods of treating tumors in immune-privileged sites |
EP2050826A2 (en) | 2007-10-16 | 2009-04-22 | Roche Diagnostics GmbH | Reagents and methods for detecting neisseria gonorrhoeae |
US20090118132A1 (en) * | 2004-11-04 | 2009-05-07 | Roche Molecular Systems, Inc. | Classification of Acute Myeloid Leukemia |
EP2058275A1 (en) | 2003-01-07 | 2009-05-13 | Ramot at Tel-Aviv University Ltd. | Peptide nanostructures encapsulating a foreign material and method of manufacturing same |
US20090123553A1 (en) * | 2002-12-09 | 2009-05-14 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures and methods of generating and using the same |
US20090126042A1 (en) * | 2004-06-14 | 2009-05-14 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
US20090143321A1 (en) * | 2005-07-07 | 2009-06-04 | Avraham Hochberg | Nucleic acid agents for downregulating h19 and methods of using same |
EP2071021A2 (en) | 2007-12-12 | 2009-06-17 | University of South Florida | Bone marrow-derived neuronal cells |
US20090156471A1 (en) * | 2004-07-15 | 2009-06-18 | Ramot At Tel Aviv University Ltd. | Use of anti-amyloid agents for treating and typing pathogen infections |
WO2009083958A2 (en) | 2007-12-27 | 2009-07-09 | Evogene Ltd. | Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress tolerance, yield and biomass in plants |
US20090209041A1 (en) * | 2002-09-06 | 2009-08-20 | Tel Aviv University Future Technology Development L.P. | Peptides and methods for inhibiting amyloid formation |
WO2009104174A2 (en) | 2008-02-21 | 2009-08-27 | Technion Research & Development Foundation Ltd . | A method of attaching a cell-of-interest to a microtube |
US20090233295A1 (en) * | 2008-01-29 | 2009-09-17 | Elias Georges | Trim59 directed diagnostics for neoplastic disease |
US20090253170A1 (en) * | 2003-06-19 | 2009-10-08 | Evogene Ltd. | Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same |
US7605149B1 (en) | 1998-07-13 | 2009-10-20 | University Of South Florida | Modulation of the phospholipase A2 pathway as a therapeutic |
EP2116618A1 (en) | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnosis and treatment of Kawasaki disease |
US20090293146A1 (en) * | 2006-12-20 | 2009-11-26 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
US7625707B2 (en) | 2003-10-02 | 2009-12-01 | Ramot At Tel Aviv University Ltd. | Antibacterial agents and methods of identifying and utilizing same |
US20090305302A1 (en) * | 2008-03-18 | 2009-12-10 | Collins Michael T | Mycobacterial culture screening test for mycobacterium avium complex bacteria |
EP2149585A1 (en) | 2003-11-04 | 2010-02-03 | Novartis Vaccines and Diagnostics, Inc. | Antagonist anti-CD40 monoclonal antibodies and methods for their use |
WO2010016806A1 (en) | 2008-08-08 | 2010-02-11 | Agency For Science, Technology And Research (A*Star) | Vhz for diagnosis and treatment of cancers |
WO2010017544A2 (en) | 2008-08-08 | 2010-02-11 | Genisphere, Inc. | Long-acting dna dendrimers and methods thereof |
US20100055033A1 (en) * | 2006-04-07 | 2010-03-04 | The Government Of The United States Of America As Represented By The Secretary | Antibody compositions and methods for treatment of neoplastic disease |
WO2010031006A1 (en) | 2008-09-12 | 2010-03-18 | Cryopraxis Criobiologia Ltda. | Ischemic tissue cell therapy |
WO2010029545A2 (en) | 2008-09-11 | 2010-03-18 | Ben Gurion University Of The Negev Research And Development Authority | Compositions and methods for treating s. pneumoniae infection |
US20100068135A1 (en) * | 2005-08-08 | 2010-03-18 | Onconon, Llc | Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility |
US7687057B2 (en) | 1998-01-09 | 2010-03-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs, and uses related thereto |
US20100081177A1 (en) * | 2008-09-05 | 2010-04-01 | TransAlgae Ltd | Decreasing RUBISCO content of algae and cyanobacteria cultivated in high carbon dioxide |
US20100080813A1 (en) * | 2008-07-25 | 2010-04-01 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
WO2010035261A2 (en) | 2008-09-29 | 2010-04-01 | Ben Gurion University Of The Negev Research And Development Authority | Amyloid beta-peptides and methods of use thereof |
EP2174668A2 (en) | 2004-11-14 | 2010-04-14 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US20100092386A1 (en) * | 2007-04-23 | 2010-04-15 | David Segev | System for delivering therapeutic agents into living cells and cells nuclei |
WO2010042481A1 (en) | 2008-10-06 | 2010-04-15 | University Of Chicago | Compositions and methods related to bacterial eap, emp, and/or adsa proteins |
US20100105608A1 (en) * | 2002-01-31 | 2010-04-29 | Tel Aviv University Future Technology Development L.P. | Peptides and methods using same for diagnosis and treatment of amyloid-associated disease |
US20100105759A1 (en) * | 2007-01-16 | 2010-04-29 | Abraham Hochberg | H19 silencing nucleic acid agents for treating rheumatoid arthritis |
EP2182052A1 (en) | 2002-10-07 | 2010-05-05 | Technion Research and Development Foundation, Ltd. | Human foreskin cells suitable for culturing stem cells |
WO2010049897A2 (en) | 2008-10-30 | 2010-05-06 | Evogene Ltd. | Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficieny |
EP2186530A1 (en) | 2000-11-17 | 2010-05-19 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
WO2010055525A1 (en) | 2008-11-17 | 2010-05-20 | Technion Research & Development Foundation Ltd. | Method for predicting a patient's responsiveness to anti-folate therapy |
WO2010058396A1 (en) | 2008-11-19 | 2010-05-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A cd44vra antibody and diagnostic and therapeutic methods using same |
WO2010061383A1 (en) | 2008-11-26 | 2010-06-03 | Biodalia Microbiological Technologies Ltd. | A method of in-situ enrichment of foods with fructan |
US20100135994A1 (en) * | 2008-07-16 | 2010-06-03 | Baylor Research Institute | Hiv vaccine based on targeting maximized gag and nef to dendritic cells |
WO2010064247A1 (en) | 2008-12-03 | 2010-06-10 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods and kits for determining predisposition to cancer |
WO2010064231A1 (en) | 2008-12-02 | 2010-06-10 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods of analyzing a-i rna editing and nucleic acid constructs capable of same |
US20100154077A1 (en) * | 2007-04-09 | 2010-06-17 | Evogene Ltd. | Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants |
WO2010071610A1 (en) | 2008-12-19 | 2010-06-24 | Agency For Science, Technology And Research (A*Star) | Severe chikungunya biomarkers |
WO2010076788A2 (en) | 2008-12-29 | 2010-07-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection |
WO2010076756A2 (en) | 2008-12-29 | 2010-07-08 | Evogene Ltd. | Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance, biomass and/or yield in plants expressing same |
WO2010076642A1 (en) | 2008-12-29 | 2010-07-08 | Tel Hashomer Medical Research, Infrastructure And Services Ltd | Peptides and compositions for prevention of cell adhesion and methods of using same |
WO2010076794A1 (en) | 2008-12-31 | 2010-07-08 | Technion Research & Development Foundation Ltd. | Method of denitrifying brine and systems capable of same |
US20100196403A1 (en) * | 2007-01-29 | 2010-08-05 | Jacob Hochman | Antibody conjugates for circumventing multi-drug resistance |
WO2010086856A2 (en) | 2009-02-01 | 2010-08-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs |
WO2010086867A2 (en) | 2009-02-02 | 2010-08-05 | Ramot At Tel Aviv University Ltd. | Peptides, pharmaceutical compositions comprising same and uses thereof |
EP2216033A2 (en) | 2003-03-06 | 2010-08-11 | Yeda Research and Development Co. Ltd. | Methods of treating disease by transplantation of allogeneic or xenogeneic organs or tissues |
WO2010089707A1 (en) | 2009-02-04 | 2010-08-12 | Yeda Research And Development Co. Ltd. | Methods and kits for determining sensitivity or resistance of prostate cancer to radiation therapy |
US20100209415A1 (en) * | 2009-01-06 | 2010-08-19 | Victoria Smith | Chemotherapeutic methods and compositions |
US20100221233A1 (en) * | 2003-12-15 | 2010-09-02 | University Of South Florida | Compositions and methods for enhancing neuroprotection via administration of stem cells and blood brain barrier permeabilizers |
WO2010097794A1 (en) | 2009-02-26 | 2010-09-02 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods of reprogramming renal cells |
WO2010100595A2 (en) | 2009-03-02 | 2010-09-10 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics |
WO2010103517A1 (en) | 2009-03-12 | 2010-09-16 | Rappaport Family Institute For Research In The Medical Sciences | Soluble compositions for the treatment of cxcr3-ligand associated diseases |
WO2010113096A1 (en) | 2009-03-30 | 2010-10-07 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods of predicting clinical course and treating multiple sclerosis |
WO2010113146A1 (en) | 2009-04-01 | 2010-10-07 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | A method of regulating proliferation and differentiation of keratinocyes |
WO2010116375A1 (en) | 2009-04-08 | 2010-10-14 | Yeda Research And Development Co. Ltd. | Isolated peptides for regulating apoptosis |
EP2243492A1 (en) | 2003-11-04 | 2010-10-27 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma |
EP2243491A1 (en) | 2003-11-04 | 2010-10-27 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-CD40 monoclonal antibodies for treatment of chronic lymphocytic leukemia |
WO2010135663A2 (en) | 2009-05-21 | 2010-11-25 | The United States Of America , As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for the detection of hiv-1/hiv-2 infection |
WO2010137017A2 (en) | 2009-05-27 | 2010-12-02 | Yeda Research And Development Co. Ltd. | Proteasome inhibitors and uses thereof |
WO2010137021A2 (en) | 2009-05-27 | 2010-12-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of generating connective tissue |
WO2010137013A1 (en) | 2009-05-27 | 2010-12-02 | Ramot At Tel Aviv University Ltd. | Crystallized photosystem i units from the pea plant and their use in solid state devices |
WO2010137020A1 (en) | 2009-05-28 | 2010-12-02 | Yeda Research And Development Co. Ltd. | Methods of treating inflammation |
US20100319088A1 (en) * | 2007-07-24 | 2010-12-16 | Gil Ronen | Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same |
WO2010150259A1 (en) | 2009-06-24 | 2010-12-29 | Fund For Medical Research Development Of Infrastructure And Health Services -Rambam Medical Center | Methods and kits for isolating placental derived microparticles and use of same for diagnosis of fetal disorders |
WO2011004361A2 (en) | 2009-07-09 | 2011-01-13 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
WO2011004379A1 (en) | 2009-07-10 | 2011-01-13 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Compositions and methods for treating cancer |
WO2011005341A2 (en) | 2009-04-03 | 2011-01-13 | University Of Chicago | Compositions and methods related to protein a (spa) variants |
US20110020357A1 (en) * | 2008-04-09 | 2011-01-27 | Technion Research & Development Foundation Ltd. | Anti human immunodeficiency antibodies and uses thereof |
WO2011010309A1 (en) | 2009-07-21 | 2011-01-27 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | A method of diagnosing cancer |
EP2279726A2 (en) | 2005-05-26 | 2011-02-02 | Biorest Ltd. | Compositions and methods using same for delivering agents into a target organ protected by a blood barrier |
WO2011013130A2 (en) | 2009-07-31 | 2011-02-03 | Ramot At Tel-Aviv University Ltd. | Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof |
US20110033473A1 (en) * | 2008-04-09 | 2011-02-10 | Yoram Reiter | Anti influenza antibodies and uses thereof |
US7888003B2 (en) | 2004-09-08 | 2011-02-15 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for the detection of HIV-1 antibodies employing polypeptides obtained from gag P6 protein |
US20110044981A1 (en) * | 2009-08-21 | 2011-02-24 | Spangler Rhyannon | Methods and compositions for treatment of pulmonary fibrotic disorders |
WO2011021171A1 (en) | 2009-08-21 | 2011-02-24 | Beeologics, Llc | Preventing and curing beneficial insect diseases via plant transcribed molecules |
WO2011021194A2 (en) | 2009-08-17 | 2011-02-24 | Technion Research & Development Foundation Ltd. | Pericyte progenitor cells and methods of generating and using same |
US20110044907A1 (en) * | 2009-08-21 | 2011-02-24 | Derek Marshall | In vivo screening assays |
EP2289567A2 (en) | 2003-12-22 | 2011-03-02 | Regentis Biomaterials Ltd. | Matrix comprising naturally-occurring crosslinked protein backbone |
US20110052501A1 (en) * | 2008-01-31 | 2011-03-03 | Liat Dassa | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
WO2011024172A2 (en) | 2009-08-27 | 2011-03-03 | Technion Research & Development Foundation Ltd. | Liposomal compositions and uses of same |
EP2292762A2 (en) | 2002-12-20 | 2011-03-09 | Board of Regents, The University of Texas System | VMP-like sequences of pathogenic Borrelia species and strains |
EP2295980A1 (en) | 2002-10-30 | 2011-03-16 | Yissum Research Development Company, of The Hebrew University of Jerusalem | Molecules and methods using same for measuring non-transferrin bound iron |
WO2011030332A2 (en) | 2009-09-08 | 2011-03-17 | Yeda Research And Development Co. Ltd. | Methods for hematopoietic precursor mobilization |
WO2011030329A1 (en) | 2009-09-10 | 2011-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of treating tumors |
WO2011030336A1 (en) | 2009-09-08 | 2011-03-17 | Ramot At Tel-Aviv University Ltd. | Methods of diagnosing amyotrophic lateral sclerosis (als) |
WO2011033506A2 (en) | 2009-09-17 | 2011-03-24 | Yeda Research And Development Co. Ltd. | Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage |
WO2011033511A1 (en) | 2009-09-17 | 2011-03-24 | Ramot At Tel-Aviv University Ltd. | Peptides for the treatment of oxidative stress related disorders |
EP2301575A1 (en) | 2003-11-04 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for solid tumors expressing the CD40 cell-surface antigen |
US20110076739A1 (en) * | 2009-08-21 | 2011-03-31 | Mccauley Scott | Catalytic domains from lysyl oxidase and loxl2 |
US20110076272A1 (en) * | 2009-08-21 | 2011-03-31 | Victoria Smith | Therapeutic methods and compositions |
US20110081706A1 (en) * | 2009-10-02 | 2011-04-07 | TransAlgae Ltd | Method and system for efficient harvesting of microalgae and cyanobacteria |
EP2308994A1 (en) | 2001-03-23 | 2011-04-13 | Yeda Research And Development Co., Ltd. | Methods for determining a risk to develop cancer |
EP2312315A1 (en) | 2005-05-18 | 2011-04-20 | Novartis AG | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
WO2011046570A1 (en) | 2009-10-16 | 2011-04-21 | The University Of Medicine And Dentistry Of New Jersey | Method for treating chronic nerve tissue injury using a cell therapy strategy |
WO2011045796A1 (en) | 2009-10-14 | 2011-04-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions for controlling varroa mites in bees |
US20110091454A1 (en) * | 2004-01-27 | 2011-04-21 | Alex Diber | Methods and systems for annotating biomolecular sequences |
US20110097771A1 (en) * | 2008-05-22 | 2011-04-28 | Eyal Emmanuel | Isolated polynucleotides and polypeptides and methods of using same for increasing plant utility |
WO2011048600A1 (en) | 2009-10-21 | 2011-04-28 | Danziger Innovations Ltd. | Generating genotypic variations in plant genomes by gamete infection |
EP2316950A1 (en) | 2000-03-27 | 2011-05-04 | Technion Research and Development Foundation, Ltd. | Single chain class I major histo-compatibility complexes, constructs encoding same and methods of generating same |
EP2316441A1 (en) | 2005-02-17 | 2011-05-04 | Hadasit Medical Research Services And Development | Bisphosphonates for treating endometriosis |
EP2319857A2 (en) | 2003-03-04 | 2011-05-11 | Yeda Research And Development Co., Ltd. | Pon polypeptides, polynucleotides encoding same and compositions and methods utilizing same |
WO2011055366A1 (en) | 2009-11-08 | 2011-05-12 | Medical Research & Development Fund For Health Services Bnai Zion Medical Center, The State Of Israel | Mo-1 conditional knock-out non-human animal and uses thereof |
WO2011058555A1 (en) | 2009-11-12 | 2011-05-19 | Yeda Research And Development Co. Ltd. | A method of editing dna in a cell and constructs capable of same |
WO2011058557A1 (en) | 2009-11-12 | 2011-05-19 | Ramot At Tel-Aviv University Ltd. | Compositions comprising pedf and uses of same in the treatment and prevention of ovary-related syndromes |
WO2011063198A2 (en) | 2009-11-20 | 2011-05-26 | St. Jude Children's Research Hospital | Methods and compositions for modulating the activity of the interleukin-35 receptor complex |
WO2011061736A1 (en) | 2009-11-17 | 2011-05-26 | Protalix Ltd. | Alkaline alpha galactosidase for the treatment of fabry disease |
WO2011064669A2 (en) | 2009-11-30 | 2011-06-03 | Pluristem Ltd. | Adherent cells from placenta and use of same in disease treatment |
WO2011064773A1 (en) | 2009-11-24 | 2011-06-03 | Collplant Ltd. | Method of generating collagen fibers |
EP2330132A1 (en) | 2003-04-04 | 2011-06-08 | Yeda Research and Development Co. Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
WO2011067745A2 (en) | 2009-12-06 | 2011-06-09 | Rosetta Green Ltd. | Compositions and methods for enhancing plants resistance to abiotic stress |
US20110145946A1 (en) * | 2008-08-18 | 2011-06-16 | Evogene Ltd. | Isolated polypeptides and polynucleotides useful for increasing nitrogen use efficiency, abiotic stress tolerance, yield and biomass in plants |
WO2011072091A1 (en) | 2009-12-09 | 2011-06-16 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the cns |
US20110150874A1 (en) * | 2006-05-19 | 2011-06-23 | Teva Pharmaceutical Industries Ltd. | Fusion proteins, uses thereof and processes for producing same |
US20110147993A1 (en) * | 2008-04-10 | 2011-06-23 | Objet Geometries Ltd. | System and method for three dimensional model printing |
EP2338896A2 (en) | 2002-12-12 | 2011-06-29 | R.B.T. (Rakuto Bio Technologies) Ltd. | Use of lignin peroxidase in skin and hair lightening |
WO2011080740A1 (en) | 2009-12-29 | 2011-07-07 | Gamida-Cell Ltd. | Methods for enhancing natural killer cell proliferation and activity |
WO2011080674A2 (en) | 2009-12-28 | 2011-07-07 | Evogene Ltd. | Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency |
US20110177112A1 (en) * | 2007-11-02 | 2011-07-21 | The Johns Hopkins University | Multi- component l2 vaccine for prevention of human papilloma virus infection |
WO2011086509A1 (en) | 2010-01-12 | 2011-07-21 | Vascular Biogenics Ltd. | Methods of producing adenovirus vectors and viral preparations generated thereby |
WO2011092700A1 (en) | 2010-01-27 | 2011-08-04 | Yeda Research And Development Co. Ltd. | Antibodies that inhibit metalloproteins |
US8000900B2 (en) | 2004-09-21 | 2011-08-16 | Microsoft Corporation | Association-based predictions of pathogen characteristics |
WO2011099006A2 (en) | 2010-02-11 | 2011-08-18 | Yeda Research And Development Co. Ltd. | Enzymatic systems for carbon fixation and methods of generating same |
EP2359853A1 (en) | 2000-08-08 | 2011-08-24 | Technion Research and Development Foundation, Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis |
US20110207144A1 (en) * | 2009-08-21 | 2011-08-25 | Derek Marshall | In vitro screening assays |
WO2011104708A2 (en) | 2010-02-24 | 2011-09-01 | Ben Gurion University Of The Negev Research And Development Authority | Methods for inhibiting necrosis |
WO2011107939A1 (en) | 2010-03-01 | 2011-09-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of predicting efficacy of an anti-vegfa treatment for solid tumors |
WO2011107994A1 (en) | 2010-03-04 | 2011-09-09 | Yeda Research And Development Co. Ltd. | Methods of measuring protein stability |
EP2365087A2 (en) | 2003-05-22 | 2011-09-14 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
WO2011111050A2 (en) | 2010-03-11 | 2011-09-15 | Jacob Edrei | Methods of generating hydrogen |
WO2011111034A1 (en) | 2010-03-08 | 2011-09-15 | Yeda Research And Development Co. Ltd. | Recombinant protein production in heterologous systems |
EP2366775A1 (en) | 2006-03-23 | 2011-09-21 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
US20110229495A1 (en) * | 2003-07-07 | 2011-09-22 | Wagner David H | Methods for predicting development of auto-immune diseases and treatment of same |
EP2368570A2 (en) | 2006-01-18 | 2011-09-28 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
WO2011125015A2 (en) | 2010-04-05 | 2011-10-13 | Bar-Ilan University | Protease-activatable pore-forming polypeptides |
WO2011127032A1 (en) | 2010-04-05 | 2011-10-13 | University Of Chicago | Compositions and methods related to protein a (spa) antibodies as an enhancer of immune response |
WO2011128897A1 (en) | 2010-04-12 | 2011-10-20 | Technion Research & Development Foundation Ltd. | Populations of pancreatic progenitor cells and methods of isolating and using same |
WO2011132182A1 (en) | 2010-04-18 | 2011-10-27 | Yeda Research And Development Co. Ltd. | MOLECULES AND METHODS OF USING SAME FOR TREATING ErbB/ErbB LIGANDS ASSOCIATED DISEASES |
WO2011135527A2 (en) | 2010-04-28 | 2011-11-03 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics |
WO2011138785A2 (en) | 2010-05-05 | 2011-11-10 | Rappaport Family Institute For Research In The Medical Sciences | Use of ccl1 in therapy |
WO2011138776A2 (en) | 2010-05-06 | 2011-11-10 | Hervana Ltd. | Biologic female contraceptives |
WO2011138778A2 (en) | 2010-05-04 | 2011-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of identifying inhibitors of polypeptides-of-interest |
WO2011141914A1 (en) | 2010-05-13 | 2011-11-17 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Isolated populations of adult renal cells and methods of isolating and using same |
EP2390312A1 (en) | 2005-11-29 | 2011-11-30 | Gamida Cell Ltd. | Methods of improving stem cell homing and engraftment |
WO2011151833A1 (en) | 2010-06-03 | 2011-12-08 | Ramot At Tel-Aviv University Ltd. | Methods of treating diabetes and compositions capable of same |
WO2011154940A1 (en) | 2010-06-07 | 2011-12-15 | Osnat Ashur-Fabian | Methods and kits for diagnosing conditions related to hypoxia |
WO2011158242A2 (en) | 2010-06-16 | 2011-12-22 | Futuragene Israel Ltd. | Pest -resistant plants containing a combination of a spider toxin and a chitinase |
WO2011158243A2 (en) | 2010-06-16 | 2011-12-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of diagnosing and treating cancer |
US8088160B2 (en) | 2000-07-20 | 2012-01-03 | Multi-Gene Vascular Systems Ltd. (“MGVS”) | Drug-eluting intravascular prostheses and methods of use |
WO2012003474A2 (en) | 2010-07-02 | 2012-01-05 | The University Of Chicago | Compositions and methods related to protein a (spa) variants |
WO2012007945A2 (en) | 2010-07-12 | 2012-01-19 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center | Isolated polynucleotides and methods and plants using same for regulating plant acidity |
WO2012007950A2 (en) | 2010-07-15 | 2012-01-19 | Technion Research & Development Foundation Ltd. | Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and diabetes-associated autoantigenic peptides |
WO2012007919A2 (en) | 2010-07-15 | 2012-01-19 | Technion Research & Development Foundation Ltd. | Nucleic acid construct for increasing abiotic stress tolerance in plants |
WO2012007951A1 (en) | 2010-07-15 | 2012-01-19 | Technion Research & Development Foundation Ltd. | Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and glutamic acid decarboxylase (gad) autoantigenic peptides |
WO2012011113A2 (en) | 2010-07-22 | 2012-01-26 | Shai Yarkoni | Regulatory immune cells with enhanced targeted cell death effect |
WO2012014208A2 (en) | 2010-07-27 | 2012-02-02 | Yeda Research And Development Co. Ltd. | Methods and systems for assessing clonality of cell cultures |
WO2012014207A2 (en) | 2010-07-27 | 2012-02-02 | Technion Research & Development Foundation Ltd. | Method for generating induced pluripotent stem cells from keratinocytes derived from plucked hair follicles |
WO2012014205A1 (en) | 2010-07-27 | 2012-02-02 | Technion Research & Development Foundation Ltd. | Isolated mesenchymal progenitor cells and extracellular matrix produced thereby |
WO2012017439A2 (en) | 2010-08-04 | 2012-02-09 | Ramot At Tel-Aviv University Ltd. | Methods of treating autoimmune diseases of the central nervous system (cns) and neurodegenerative diseases |
WO2012025914A1 (en) | 2010-08-22 | 2012-03-01 | Ramot At Tel-Aviv University Ltd. | Induced pluripotent stem cells derived from human pancreatic beta cells |
WO2012025925A1 (en) | 2010-08-24 | 2012-03-01 | Rappaport Family Institute For Research In The Medical Sciences | Methods of improving transplantation using sdf-1alpha |
EP2425841A1 (en) | 2000-11-24 | 2012-03-07 | Vascular Biogenics Ltd. | Methods Employing and Compositions Containing Defined Oxidized Phospholipids for Prevention and Treatment of Atherosclerosis |
WO2012032510A1 (en) | 2010-09-07 | 2012-03-15 | Yeda Research And Development Co. Ltd. | Primers for amplifying dna and methods of selecting same |
WO2012032521A2 (en) | 2010-09-07 | 2012-03-15 | Technion Research & Development Foundation Ltd. | Novel methods and culture media for culturing pluripotent stem cells |
WO2012032526A2 (en) | 2010-09-08 | 2012-03-15 | Yeda Research And Development Co. Ltd. | Use of anti third party central memory t cells for anti-leukemia/lymphoma treatment |
WO2012032525A2 (en) | 2010-09-08 | 2012-03-15 | Yeda Research And Development Co. Ltd. | An immunosuppressive drug combination for a stable and long term engraftment |
WO2012032519A2 (en) | 2010-09-07 | 2012-03-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of diagnosing parkinson's disease |
WO2012032520A1 (en) | 2010-09-07 | 2012-03-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Readthrough acetylcholinesterase (ache-r) for treating or preventing parkinson's disease |
WO2012034067A1 (en) | 2010-09-09 | 2012-03-15 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
WO2012035539A1 (en) | 2010-09-15 | 2012-03-22 | Ramot At Tel-Aviv University Ltd. | Methods of expanding and redifferentiating islet beta cells |
WO2012038956A1 (en) | 2010-09-20 | 2012-03-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of treating neurodegenerative diseases |
EP2441840A1 (en) | 2005-07-18 | 2012-04-18 | Protalix Ltd. | Mucosal or enteral administration of biologically active macromolecules |
WO2012052878A1 (en) | 2010-10-19 | 2012-04-26 | Vascular Biogenics Ltd. | Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells |
WO2012052872A2 (en) | 2010-10-17 | 2012-04-26 | Yeda Research And Development Co. Ltd. | Methods and compositions for the treatment of insulin-associated medical conditions |
WO2012056455A1 (en) | 2010-10-28 | 2012-05-03 | Yeda Research And Development Co. Ltd. | Methods of generating antibodies to metalloenzymes |
WO2012056452A2 (en) | 2010-10-27 | 2012-05-03 | Nanocyte (Israel) Ltd. | Pharmaceutical compositions and delivery devices comprising stinging cells or capsules |
WO2012059925A2 (en) | 2010-11-04 | 2012-05-10 | Ben-Gurion University Of The Negev Research And Development Authority | Acyl-coa: diacylglycerol acyltransferase 1-like gene (ptdgat1) and uses thereof |
WO2012059922A2 (en) | 2010-11-03 | 2012-05-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Transgenic plants with improved saccharification yields and methods of generating same |
WO2012066495A2 (en) | 2010-11-17 | 2012-05-24 | Ben Gurion University Of The Negev Research And Development Authority | T-cell therapy to neurodegenerative diseases |
EP2457999A2 (en) | 2002-12-16 | 2012-05-30 | Technion Research & Development Foundation Ltd. | Culture medium for pluropotent stem cells |
WO2012073238A1 (en) | 2010-12-02 | 2012-06-07 | Technion Research & Development Foundation Ltd. | Methods of generating corneal cells and cell populations comprising same |
WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
EP2463382A1 (en) | 2010-12-07 | 2012-06-13 | Enterologics, Inc. | Method for identifying E. Coli M-17 |
WO2012081029A1 (en) | 2010-12-15 | 2012-06-21 | Kadimastem Ltd. | Insulin producing cells derived from pluripotent stem cells |
WO2012090205A2 (en) | 2010-12-28 | 2012-07-05 | Kamedis Ltd. | Plant extracts for the treatment and prevention of infections |
WO2012098537A1 (en) | 2011-01-20 | 2012-07-26 | Protalix Ltd. | Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells |
WO2012104851A1 (en) | 2011-01-31 | 2012-08-09 | Yeda Research And Development Co. Ltd. | Methods of diagnosing disease using overlap extension pcr |
EP2487182A2 (en) | 2005-07-07 | 2012-08-15 | FULCRUM SP Ltd. | SP1 polypeptides, modified SP1 polypeptides and uses thereof |
US8252588B2 (en) | 2003-04-08 | 2012-08-28 | Yeda Research And Development Co. Ltd. | Stem cells having increased sensitivity to SDF-1 and methods of generating and using same |
EP2492279A1 (en) | 2011-02-25 | 2012-08-29 | Laboratorios Del. Dr. Esteve, S.A. | Rapid immunogen selection method using lentiviral display |
WO2012114339A1 (en) | 2011-02-23 | 2012-08-30 | Rappaport Family Institute For Research In The Medical Sciences | High affinity molecules capable of binding a type a plexin receptor and uses of same |
WO2012117406A2 (en) | 2011-03-02 | 2012-09-07 | Futuragene Israel Ltd. | Bacterial resistant transgenic plants |
WO2012117373A1 (en) | 2011-03-03 | 2012-09-07 | Ramot At Tel-Aviv University Ltd. | Genetically modified muscle cells which express neurotrophic factors |
WO2012120500A2 (en) | 2011-03-06 | 2012-09-13 | Merck Serono S.A. | Low fucose cell lines and uses thereof |
WO2012120518A1 (en) | 2011-03-08 | 2012-09-13 | Ramot At Tel-Aviv University Ltd. | Compositions and methods for diagnosing and treating phenylketonuria (pku) |
EP2500428A2 (en) | 2007-07-11 | 2012-09-19 | Yeda Research and Development Co. Ltd. | Nucleic acid construct systems capable of diagnosing or treating a cell state |
WO2012123949A1 (en) | 2011-03-17 | 2012-09-20 | Ramot At Tel-Aviv University Ltd. | Bi- and monospecific, asymmetric antibodies and methods of generating the same |
WO2012123938A1 (en) | 2011-03-17 | 2012-09-20 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Quinolone analogs for treating autoimmune diseases |
WO2012127475A1 (en) | 2011-03-24 | 2012-09-27 | Neurim Pharmaceuticals (1991) Ltd. | Neuroprotective peptides |
WO2012127320A1 (en) | 2011-03-22 | 2012-09-27 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
WO2012131680A2 (en) | 2011-03-28 | 2012-10-04 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating inflammation |
EP2508596A2 (en) | 2002-02-21 | 2012-10-10 | Bayer Healthcare | MN/CA IX-specific monoclonal antibodies generated from MN/CA IX-deficient mice and methods of use |
WO2012137202A1 (en) | 2011-04-05 | 2012-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Composition comprising an iron indicator attached to a microparticle and uses of same for quantifying non-transferrin bound iron (ntbi) and cellular labile iron (lci) |
WO2012137207A1 (en) | 2011-04-06 | 2012-10-11 | Ramot At Tel-Aviv University Ltd. | Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same |
WO2012140519A2 (en) | 2011-04-15 | 2012-10-18 | Pluristem Ltd. | Methods and systems for harvesting cells |
WO2012150600A2 (en) | 2011-05-04 | 2012-11-08 | Ramot At Tel-Aviv University Ltd. | Regulation of amyloid beta molecular composition for the treatment of alzheimer's disease |
WO2012153333A1 (en) | 2011-05-09 | 2012-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Regeneration and repair of mesenchymal tissue using amelogenin |
WO2012153336A2 (en) | 2011-05-12 | 2012-11-15 | Rakuto Bio Technologies Ltd. | Methods and device for lightening skin complexion |
WO2012156976A1 (en) | 2011-05-16 | 2012-11-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of producing artemisinin in non-host plants and vectors for use in same |
EP2526952A1 (en) | 2003-07-15 | 2012-11-28 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
EP2527441A2 (en) | 2007-07-15 | 2012-11-28 | Technion Research & Development Foundation | Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis |
WO2012160526A2 (en) | 2011-05-23 | 2012-11-29 | Ofir Menashe | Formulations of microorganism comprising particles and uses of same |
US8323636B2 (en) | 2006-02-03 | 2012-12-04 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
EP2529754A1 (en) | 2007-05-03 | 2012-12-05 | Agency For Science, Technology And Research (A*star) | Antibodies binding to an intracellular PRL-1 or PRL-3 polypeptide |
WO2012164380A2 (en) | 2011-05-31 | 2012-12-06 | Hutchison Biofilm Medical Solutions Limited | Dispersion and detachment of cell aggregates |
WO2012164565A1 (en) | 2011-06-01 | 2012-12-06 | Yeda Research And Development Co. Ltd. | Compositions and methods for downregulating prokaryotic genes |
WO2012172555A1 (en) | 2011-06-14 | 2012-12-20 | Yeda Research And Development Co. Ltd. | Combination therapy to prevent dcis formation and progression to breast cancer |
WO2012176203A1 (en) | 2011-06-23 | 2012-12-27 | Kaiima Bio Agritech Ltd. | Common wheat, plants or parts thereof having partially or fully multiplied genome, hybrids and products thereof and methods of generating and using same |
US8352031B2 (en) | 2004-03-10 | 2013-01-08 | Impulse Dynamics Nv | Protein activity modification |
WO2013011507A1 (en) | 2011-07-20 | 2013-01-24 | Kaiima Bio Agritech Ltd. | Maize plants having a partially or fully multiplied genome and uses thereof |
WO2013011347A1 (en) | 2011-07-18 | 2013-01-24 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
EP2550982A1 (en) | 2011-07-27 | 2013-01-30 | Technion Research & Development Foundation Ltd. | Devices for surgical applications |
WO2013018098A2 (en) | 2011-08-02 | 2013-02-07 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
WO2013018060A2 (en) | 2011-08-04 | 2013-02-07 | Yeda Research And Development Co. Ltd. | Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
WO2013021389A2 (en) | 2011-08-09 | 2013-02-14 | Yeda Research And Development Co.Ltd. | Downregulation of mir-7 for promotion of beta cell differentiation and insulin production |
WO2013024481A1 (en) | 2011-08-14 | 2013-02-21 | Kaiima Bio Agritech Ltd. | Durum wheat plants having a partially or fully multiplied genome and uses thereof |
EP2561889A2 (en) | 2002-08-01 | 2013-02-27 | Yeda Research and Development Co. Ltd. | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels |
US8388954B2 (en) | 2003-04-09 | 2013-03-05 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Stabilising formulation for immunoglobulin G compositions in liquid form and in lyophilised form |
WO2013035070A1 (en) | 2011-09-07 | 2013-03-14 | Yeda Research And Development Co. Ltd. | Olfactory signature and odorant mixture having the same |
WO2013035071A1 (en) | 2011-09-08 | 2013-03-14 | Yeda Research And Development Co. Ltd. | Novel risk biomarkers for lung cancer |
WO2013035099A1 (en) | 2011-09-08 | 2013-03-14 | Yeda Research And Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
US8415318B2 (en) | 2001-10-19 | 2013-04-09 | Vascular Biogenics Ltd. | Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
EP2581445A1 (en) | 2007-08-15 | 2013-04-17 | Yeda Research And Development Co. Ltd. | Regulators of MMP-9 and uses thereof |
WO2013054331A1 (en) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
US8426166B2 (en) | 2006-02-03 | 2013-04-23 | Prolor Biotech Inc. | Long-acting polypeptides and methods of producing same |
WO2013056377A1 (en) | 2011-10-21 | 2013-04-25 | Augurex Life Sciences Corporation | Antigens derived from citrullinated 14-3-3 and uses thereof in the diagnosis of rheumatoid arthritis |
WO2013061328A2 (en) | 2011-10-27 | 2013-05-02 | Yeda Research And Development Co. Ltd. | Method of treating cancer |
WO2013067076A2 (en) | 2011-11-03 | 2013-05-10 | Quark Pharmaceuticals, Inc. | Methods and compositions for neuroprotection |
EP2591789A2 (en) | 2007-09-19 | 2013-05-15 | Pluristem Ltd. | Adherent cells from adipose or placenta tissues and use thereof in therapy |
WO2013070821A1 (en) | 2011-11-08 | 2013-05-16 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the nervous system |
WO2013076729A1 (en) | 2011-11-23 | 2013-05-30 | Danziger Dan Flower Farm | Otomeria plants |
WO2013076730A1 (en) | 2011-11-27 | 2013-05-30 | Yeda Research And Development Co. Ltd. | Methods of regulating angiogenesis and compositions capable of same |
EP2599790A1 (en) | 2007-11-26 | 2013-06-05 | Yissum Research Development Company of The Hebrew University of Jerusalem | Compositions comprising fibrous polypeptides and polysachharides |
WO2013084190A1 (en) | 2011-12-08 | 2013-06-13 | Yeda Research And Development Co. Ltd. | Mammalian fetal pulmonary cells and therapeutic use of same |
WO2013093921A1 (en) | 2011-12-20 | 2013-06-27 | Collplant Ltd. | Collagen coated synthetic polymer fibers |
WO2013093920A2 (en) | 2011-12-22 | 2013-06-27 | Yeda Research And Development Co. Ltd. | A combination therapy for a stable and long term engraftment |
US8478535B2 (en) | 2004-10-29 | 2013-07-02 | Microsoft Corporation | Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails |
WO2013098820A1 (en) | 2011-12-28 | 2013-07-04 | Kaiima Bio Agritech Ltd. | Cultivated sorghum plant having a partially or fully multiplied genome and uses of same |
WO2013098813A1 (en) | 2012-01-01 | 2013-07-04 | Qbi Enterprises Ltd. | Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents |
EP2620493A1 (en) | 2008-05-28 | 2013-07-31 | Ramot at Tel Aviv University Ltd. | Mesenchymal stem cells for the treatment of CNS diseases |
WO2013114373A1 (en) | 2012-02-01 | 2013-08-08 | Protalix Ltd. | Inhalable liquid formulations of dnase i |
WO2013114363A2 (en) | 2012-01-30 | 2013-08-08 | Yeda Research And Development Co.Ltd. | Antimicrobial agents |
WO2013121416A1 (en) | 2012-02-14 | 2013-08-22 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
WO2013121427A1 (en) | 2012-02-13 | 2013-08-22 | Gamida-Cell Ltd. | Mesenchymal stem cells conditioned medium and methods of generating and using the same |
WO2013121405A1 (en) | 2012-02-19 | 2013-08-22 | Protalix Ltd. | Oral unit dosage forms and uses of same for the treatment of gaucher disease |
WO2013124817A2 (en) | 2012-02-22 | 2013-08-29 | Brainstem Biotec Ltd. | MicroRNAS FOR THE GENERATION OF ASTROCYTES |
WO2013124816A2 (en) | 2012-02-22 | 2013-08-29 | Brainstem Biotec Ltd. | Generation of neural stem cells and motor neurons |
EP2633854A1 (en) | 2008-12-05 | 2013-09-04 | Yeda Research And Development Co. Ltd. | miRNA-9 or miRNA-9* for use in treating MND |
WO2013128454A1 (en) | 2012-03-01 | 2013-09-06 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center | Male sterile garlic plants, hybrid offspring of same and methods of generating and using same |
WO2013132495A1 (en) | 2012-03-07 | 2013-09-12 | Yeda Research And Development Co. Ltd. | Compositions for inhibition of quiescin sulfhydryl oxidase (qsox1) and uses of same |
WO2013136335A1 (en) | 2012-03-15 | 2013-09-19 | Yeda Research And Development Co. Ltd. | Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage |
EP2641606A1 (en) | 2008-05-27 | 2013-09-25 | Pluristem Ltd. | Methods of treating inflammatory colon diseases |
WO2013140247A1 (en) | 2012-03-20 | 2013-09-26 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
WO2013140389A1 (en) | 2012-03-22 | 2013-09-26 | Ramot At Tel-Aviv University Ltd. | Plif multimeric peptides and uses thereof |
WO2013153553A2 (en) | 2012-04-13 | 2013-10-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions for controlling varroa mites in bees |
WO2013162746A1 (en) | 2012-04-26 | 2013-10-31 | University Of Chicago | Staphylococcal coagulase antigens and methods of their use |
WO2013160895A1 (en) | 2012-04-24 | 2013-10-31 | Biokine Therapeutics Ltd. | Peptides and use thereof in the treatment of large cell lung cancer |
WO2013168164A1 (en) | 2012-05-09 | 2013-11-14 | Yeda Research And Development Co. Ltd. | Variants of tace pro-domain as tnf-a inhibitor and their medical use |
WO2013175480A1 (en) | 2012-05-24 | 2013-11-28 | A.B. Seeds Ltd. | Compositions and methods for silencing gene expression |
WO2013174003A1 (en) | 2012-05-24 | 2013-11-28 | Mountgate Group Limited | Compositions and methods related to prevention and treatment of rabies infection |
WO2013183052A1 (en) | 2012-06-04 | 2013-12-12 | Prolor Biotech Inc. | Pegylated oxm variants |
WO2013183048A1 (en) | 2012-06-03 | 2013-12-12 | Ben-Gurion University Of The Negev Research And Development Authority | Functionalized titanium binding peptides and implants coated with same |
WO2014006621A1 (en) | 2012-07-03 | 2014-01-09 | Nanospun Technologies Ltd. | Methods and devices for adsorption and biodegradation of petroleum |
WO2014020608A1 (en) | 2012-07-31 | 2014-02-06 | Yeda Research And Development Co. Ltd. | Methods of diagnosing and treating motor neuron diseases |
WO2014020599A1 (en) | 2012-07-29 | 2014-02-06 | Yeda Research And Development Co. Ltd. | Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms |
WO2014024183A1 (en) | 2012-08-06 | 2014-02-13 | Brainstorm Cell Therapeutics Ltd. | Methods of generating mesenchymal stem cells which secrete neurotrophic factors |
EP2698377A1 (en) | 2012-08-17 | 2014-02-19 | Laboratorios Del. Dr. Esteve, S.A. | Enhanced rapid immunogen selection method for HIV gp120 variants |
WO2014033723A1 (en) | 2012-09-03 | 2014-03-06 | A.B. Seeds Ltd. | Method of improving abiotic stress tolerance of plants and plants generated thereby |
WO2014041544A1 (en) | 2012-09-12 | 2014-03-20 | Ramot At Tel-Aviv University Ltd. | Immunoparticles and methods of generating and using same |
US8680246B2 (en) | 2010-02-04 | 2014-03-25 | Gilead Biologics, Inc. | Antibodies that bind to lysyl oxidase-like 2 (LOXL2) |
WO2014052588A1 (en) | 2012-09-27 | 2014-04-03 | Research Development Foundation | Attenuated chikungunya virus |
EP2716654A1 (en) | 2005-10-24 | 2014-04-09 | Evogene Ltd. | Isolated polypeptides, polynucleotides encoding same, transgenic plants expressing same and methods of using same |
WO2014057490A1 (en) | 2012-10-09 | 2014-04-17 | Ramot At Tel-Aviv University Ltd. | Methods and kits for predicting prognosis of cancer using soluble mortalin in blood |
WO2014064682A1 (en) | 2012-10-24 | 2014-05-01 | Yeda Research And Development Co. Ltd. | Combinations of epidermal growth factor receptor targeting antibodies for treating cancer |
WO2014068553A1 (en) | 2012-10-29 | 2014-05-08 | Yeda Research And Development Co. Ltd. | Aptamers, multimeric aptamers and uses thereof |
WO2014083567A2 (en) | 2012-11-29 | 2014-06-05 | Yeda Research And Development Co. Ltd. | Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors |
US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
US8775526B2 (en) | 2006-01-16 | 2014-07-08 | Zlango Ltd. | Iconic communication |
WO2014106838A2 (en) | 2013-01-01 | 2014-07-10 | A.B. Seeds Ltd. | Methods of introducing dsrna to plant seeds for modulating gene expression |
WO2014108854A1 (en) | 2013-01-09 | 2014-07-17 | Fusimab Ltd. | Monospecific anti-hgf and anti-ang2 antibodies and bispecific anti-hgf/anti-ang2 antibodies |
WO2014108850A2 (en) | 2013-01-09 | 2014-07-17 | Yeda Research And Development Co. Ltd. | High throughput transcriptome analysis |
WO2014111936A1 (en) | 2013-01-17 | 2014-07-24 | Novellusdx Ltd. | Methods and systems for identifying patient specific driver mutations |
WO2014118785A1 (en) | 2013-02-04 | 2014-08-07 | Ramot At Tel-Aviv University Ltd. | Generation of cytotoxic tumor specific cell lines and uses thereof |
WO2014138696A1 (en) | 2013-03-07 | 2014-09-12 | University Of Maryland, Baltimore | Immunotherapeutic potential of modified lipooligosaccharides/lipid a |
WO2014136113A1 (en) | 2013-03-06 | 2014-09-12 | Protalix Ltd. | Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same |
WO2014136117A1 (en) | 2013-03-06 | 2014-09-12 | Protalix Ltd. | USE OF PLANT CELLS EXPRESSING A TNFalpha POLYPEPTIDE INHIBITOR IN THERAPY |
EP2781223A1 (en) | 2007-10-19 | 2014-09-24 | Rappaport Family Institute for Research in the Medical Sciences | Compositions comprising semaphorins for the treatment of angiogenesis related diseases |
WO2014147622A1 (en) | 2013-03-21 | 2014-09-25 | Collplant Ltd. | Compositions comprising collagen and prp for tissue regeneration |
US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
WO2014155376A1 (en) | 2013-03-24 | 2014-10-02 | Biokine Therapeutics Ltd. | Methods of treating myeloid leukemia |
EP2789626A2 (en) | 2008-09-24 | 2014-10-15 | Tel Hashomer Medical Research Infrastructure and Services Ltd. | Peptides and compositions for prevention of cell adhesion and methods of using same |
US8865158B2 (en) | 2012-05-22 | 2014-10-21 | Ramot At Tel-Aviv University Ltd. | Bacteriophages for reducing toxicity of bacteria |
US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
WO2014174520A1 (en) | 2013-04-25 | 2014-10-30 | Yeda Research And Development Co. Ltd. | Use of inhibitory peptides for the treatment of inflammatory diseases |
WO2014174511A1 (en) | 2013-04-21 | 2014-10-30 | Yeda Research And Development Co. Ltd. | Agents for downregulation of the activity and/or amount of bcl-xl and/or bcl-w |
WO2014174470A1 (en) | 2013-04-23 | 2014-10-30 | Yeda Research And Development Co. Ltd. | Isolated naive pluripotent stem cells and methods of generating same |
WO2014188423A1 (en) | 2013-05-21 | 2014-11-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Treatment of mast cell related pathologies |
WO2014191995A2 (en) | 2013-05-27 | 2014-12-04 | Rakuto Bio Technologies Ltd. | Enzymatic system-containing cosmetic compositions |
EP2816117A2 (en) | 2004-09-29 | 2014-12-24 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
WO2014207744A1 (en) | 2013-06-24 | 2014-12-31 | Ramot At Tel-Aviv University Ltd. | Omentum based scaffold and delivery system |
US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
WO2015015489A1 (en) | 2013-07-30 | 2015-02-05 | Biolinerx Ltd. | Antibody for treating diabetes and autoimmune diseases |
EP2839839A1 (en) | 2007-02-28 | 2015-02-25 | Yeda Research And Development Company Limited | Nuclear targeting sequences |
WO2015033344A1 (en) | 2013-09-05 | 2015-03-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and kits for inhibiting pathogenicity of group a streptococcus (gas) or group g streptococcus (ggs) |
WO2015033337A1 (en) | 2013-09-03 | 2015-03-12 | Technion Research & Development Foundation Limited. | A flap for de-novo tissue regeneration |
WO2015033343A1 (en) | 2013-09-03 | 2015-03-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for expressing recombinant polypeptides |
WO2015037009A1 (en) | 2013-09-16 | 2015-03-19 | Plexicure Ltd. | Isolated proteins capable of binding plexin-a4 and methods of producing and using same |
WO2015040609A1 (en) | 2013-09-17 | 2015-03-26 | Yeda Research And Development Co. Ltd. | Erk-derived peptides and uses thereof |
WO2015049677A1 (en) | 2013-10-01 | 2015-04-09 | Kadimastem Ltd. | Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of amyotrophic lateral sclerosis (als) |
WO2015059695A1 (en) | 2013-10-21 | 2015-04-30 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
WO2015059690A1 (en) | 2013-10-24 | 2015-04-30 | Yeda Research And Development Co. Ltd. | Polynucleotides encoding brex system polypeptides and methods of using s ame |
WO2015063768A1 (en) | 2013-10-31 | 2015-05-07 | Biokine Therapeutics Ltd. | Methods of treating acute myeloid leukemia with a flt3 mutation |
WO2015079411A1 (en) | 2013-11-28 | 2015-06-04 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Rna polymerase i inhibitors and uses thereof |
WO2015079413A2 (en) | 2013-11-28 | 2015-06-04 | Yeda Research And Development Co. Ltd. | Synaptojanin-2 inhibitors and uses thereof |
US9057092B2 (en) | 2006-03-06 | 2015-06-16 | Zetiq Technologies Ltd. | Methods and compositions for identifying a cell phenotype |
WO2015087327A1 (en) | 2013-12-10 | 2015-06-18 | Yeda Research And Development Co. Ltd. | Use of enzymes which catalyze pyruvate synthesis from formate and acetyl-coa and bacteria expressing same |
EP2889041A1 (en) | 2005-07-26 | 2015-07-01 | Rutgers, The State University of New Jersey | Kit of reagents for tuberculosis assay |
US9096645B2 (en) | 2010-11-15 | 2015-08-04 | Ramot At Tel-Aviv University Ltd. | Dipeptide analogs for treating conditions associated with amyloid fibril formation |
US9096865B2 (en) | 2009-06-10 | 2015-08-04 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance |
WO2015114633A1 (en) | 2014-01-30 | 2015-08-06 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. | Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same |
WO2015114638A2 (en) | 2014-02-03 | 2015-08-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of eliminating stem cells |
WO2015118537A2 (en) | 2014-02-05 | 2015-08-13 | Yeda Research And Development Co. Ltd. | Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
WO2015118538A1 (en) | 2014-02-06 | 2015-08-13 | Yeda Research And Development Co. Ltd. | Anti cd84 antibodies, compositions comprising same and uses thereof |
WO2015118547A1 (en) | 2014-02-10 | 2015-08-13 | Protalix Ltd. | Method of maintaining disease stability in a subject having gaucher's disease |
WO2015121859A1 (en) | 2014-02-11 | 2015-08-20 | Brainstorm Cell Therapeutics Ltd. | Method of qualifying cells |
US9121022B2 (en) | 2010-03-08 | 2015-09-01 | Monsanto Technology Llc | Method for controlling herbicide-resistant plants |
WO2015132784A1 (en) | 2014-03-03 | 2015-09-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method and device for detection of pseudomonas aeruginosa |
EP2923709A1 (en) | 2014-03-28 | 2015-09-30 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Multi-component-multistage malaria vaccine |
US9150644B2 (en) | 2011-04-12 | 2015-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II |
US9156865B2 (en) | 2007-04-23 | 2015-10-13 | Deliversir Ltd | System for delivering therapeutic agents into living cells and cells nuclei |
WO2015159293A2 (en) | 2014-04-14 | 2015-10-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
WO2015159295A1 (en) | 2014-04-17 | 2015-10-22 | Yeda Research And Development Co. Ltd. | Methods and kits for analyzing dna binding moieties attached to dna |
EP2936976A1 (en) | 2008-04-21 | 2015-10-28 | Danziger Innovations Ltd. | Plant viral expression vectors and use of same for generating genotypic variations in plant genomes |
US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
WO2015166492A2 (en) | 2014-04-28 | 2015-11-05 | Yeda Research And Development Co. Ltd. | Microbiome response to agents |
US9182403B2 (en) | 2009-05-19 | 2015-11-10 | Zetiq Technologies Ltd. | Kits for and methods of differential staining of cervical cancer cells and/or tissues |
WO2015170324A2 (en) | 2014-05-04 | 2015-11-12 | Forrest Innovations Ltd. | Compositions for mosquito control and uses of same |
WO2015177800A2 (en) | 2014-05-22 | 2015-11-26 | Yeda Research And Development Co. Ltd. | Recombinant microorganisms capable of carbon fixation |
WO2015186129A1 (en) | 2014-06-02 | 2015-12-10 | Technion Research & Development Foundation Limited. | Compositions and methods of selectively inhibiting irp1 and treating inflammation |
WO2015186128A1 (en) | 2014-06-02 | 2015-12-10 | Kadimastem Ltd. | Methods of inducing myelination and maturation of oligodendrocytes |
WO2015198320A1 (en) | 2014-06-24 | 2015-12-30 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
EP2960250A1 (en) | 2008-07-16 | 2015-12-30 | Institute for Research in Biomedicine | Human cytomegalovirus neutralising antibodies and use thereof |
WO2015198334A2 (en) | 2014-06-25 | 2015-12-30 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Identification of cancer stem cells and use of same for diagnosis and treatment |
WO2016005985A2 (en) | 2014-07-09 | 2016-01-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method for reprogramming cells |
WO2016009436A1 (en) | 2014-07-15 | 2016-01-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Isolated polypeptides of cd44 and uses thereof |
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
WO2016016894A1 (en) | 2014-07-30 | 2016-02-04 | Yeda Research And Development Co. Ltd. | Media for culturing pluripotent stem cells |
WO2016024278A1 (en) | 2014-08-14 | 2016-02-18 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
EP2990421A1 (en) | 2009-04-30 | 2016-03-02 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Anti ceacam1 antibodies and methods of using same |
WO2016030899A1 (en) | 2014-08-28 | 2016-03-03 | Yeda Research And Development Co. Ltd. | Methods of treating amyotrophic lateral scleroses |
EP2992895A1 (en) | 2014-09-08 | 2016-03-09 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Three-component-multistage malaria vaccine |
WO2016038610A1 (en) | 2014-09-08 | 2016-03-17 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki) |
WO2016038609A1 (en) | 2014-09-08 | 2016-03-17 | Yeda Research And Development Co. Ltd. | Anti-her3 antibodies and uses of same |
WO2016038616A1 (en) | 2014-09-14 | 2016-03-17 | Yeda Research And Development Co. Ltd. | Nmda receptor antagonists for treating gaucher disease |
WO2016042561A2 (en) | 2014-09-21 | 2016-03-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Downregulating mir-132 for the treatment of lipid related disorders |
EP3006039A1 (en) | 2004-03-02 | 2016-04-13 | Acceleron Pharma Inc. | Alk7 polypeptides for use in promoting fat loss |
WO2016055950A1 (en) | 2014-10-08 | 2016-04-14 | Novartis Ag | Combination of human cytomegalovirus neutralizing antibodies |
EP3009449A1 (en) | 2008-07-16 | 2016-04-20 | Institute for Research in Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
WO2016064887A1 (en) | 2014-10-20 | 2016-04-28 | Gen-Probe Incorporated | Red blood cell lysis solution |
EP3020410A1 (en) | 2008-04-18 | 2016-05-18 | Collplant Ltd. | Methods of generating and using procollagen |
WO2016075697A1 (en) | 2014-11-13 | 2016-05-19 | Enzootic Holdings Ltd. | Functional sex-reversal of decapod crustacean females |
WO2016075546A2 (en) | 2014-11-14 | 2016-05-19 | Antonio Lanzavecchia | Antibodies that neutralize ebola virus and uses thereof |
WO2016079731A2 (en) | 2014-11-17 | 2016-05-26 | Yeda Research And Development Co. Ltd. | Method of analyzing microbiome |
WO2016079736A2 (en) | 2014-11-17 | 2016-05-26 | Yeda Research And Development Co. Ltd. | Methods of treating diseases related to mitochondrial function |
WO2016079739A2 (en) | 2014-11-20 | 2016-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells |
EP3026057A2 (en) | 2009-03-09 | 2016-06-01 | Ramot at Tel Aviv University Ltd. | Compositions for prevention and treatment of neurodegenerative diseases |
WO2016084084A1 (en) | 2014-11-27 | 2016-06-02 | Danziger Innovations Ltd. | Nucleic acid constructs for genome editing |
WO2016084088A1 (en) | 2014-11-26 | 2016-06-02 | Ramot At Tel-Aviv University Ltd. | Targeted elimination of bacterial genes |
WO2016092555A2 (en) | 2014-12-11 | 2016-06-16 | Yeda Research And Development Co. Ltd. | Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage |
WO2016103269A1 (en) | 2014-12-23 | 2016-06-30 | Ramot At Tel-Aviv University Ltd. | Populations of neural progenitor cells and methods of producing and using same |
WO2016108244A1 (en) | 2015-01-04 | 2016-07-07 | Protalix Ltd. | Modified dnase and uses thereof |
WO2016108219A1 (en) | 2014-12-30 | 2016-07-07 | Cell Cure Neurosciences Ltd. | Methods of treating retinal diseases |
WO2016108240A1 (en) | 2014-12-30 | 2016-07-07 | Cell Cure Neurosciences Ltd. | Assessing retinal pigment epithelial cell populations |
WO2016108239A1 (en) | 2014-12-30 | 2016-07-07 | Cell Cure Neurosciences Ltd. | Rpe cell populations and methods of generating same |
WO2016116935A1 (en) | 2015-01-21 | 2016-07-28 | Yeda Research And Development Co. Ltd. | Use of rasa2 as a prognostic and therapeutic marker for melanoma |
US9416363B2 (en) | 2011-09-13 | 2016-08-16 | Monsanto Technology Llc | Methods and compositions for weed control |
US9422557B2 (en) | 2011-09-13 | 2016-08-23 | Monsanto Technology Llc | Methods and compositions for weed control |
US9422558B2 (en) | 2011-09-13 | 2016-08-23 | Monsanto Technology Llc | Methods and compositions for weed control |
WO2016135732A1 (en) | 2015-02-26 | 2016-09-01 | Yeda Research And Development Co. Ltd. | Method of promoting hair growth |
WO2016142948A1 (en) | 2015-03-11 | 2016-09-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Decoy oligonucleotides for the treatment of diseases |
WO2016147194A1 (en) | 2015-03-19 | 2016-09-22 | Yeda Research And Development Co. Ltd. | Anti amphiregulin antibodies, compositions comprising same and uses thereof |
US9458438B2 (en) | 2010-04-12 | 2016-10-04 | Ben Gurion University Of The Negev Research And Development Authority | Sulfotransferase of a red microalga and uses thereof |
US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
WO2016157192A1 (en) | 2015-04-01 | 2016-10-06 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Erodium crassifolium l'her plant extracts and uses thereof |
WO2016160618A2 (en) | 2015-03-27 | 2016-10-06 | University Of Southern California | Car t-cell therapy directed to lhr for the treatment of solid tumors |
WO2016157190A1 (en) | 2015-03-31 | 2016-10-06 | Yeda Research And Development Co. Ltd. | Glutamate oxaloacetate transaminase 1 (got1), preparations and methods of generating same and uses thereof |
WO2016162870A1 (en) | 2015-04-07 | 2016-10-13 | Ilana Nathan | Compositions for treating and/or preventing cell or tissue necrosis specifically targeting cathepsin c and/or cela1 and/or cela3a and/or structurally related enzymes thereto |
WO2016174673A1 (en) | 2015-04-29 | 2016-11-03 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Anti-phytopathogenic compositions |
WO2016174674A1 (en) | 2015-04-27 | 2016-11-03 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Egr1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions |
WO2016174652A1 (en) | 2015-04-30 | 2016-11-03 | Technion Research & Development Foundation Limited | Chimeric antigen receptors and methods of their use |
WO2016178207A1 (en) | 2015-05-04 | 2016-11-10 | Ramot At Tel-Aviv University Ltd. | Methods and kits for fragmenting dna |
WO2016181393A1 (en) | 2015-05-11 | 2016-11-17 | Yeda Research And Development Co. Ltd. | Citrin inhibitors for the treatment of cancer |
WO2016185469A1 (en) | 2015-05-21 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Bacterial populations for promoting health |
WO2016185471A1 (en) | 2015-05-17 | 2016-11-24 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Compositions and methods for treating cancer |
WO2016185481A2 (en) | 2015-05-20 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Method of targeting senescent cells |
WO2016185457A1 (en) | 2015-05-19 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Methods of promoting lymphangiogenesis |
WO2016197064A1 (en) | 2015-06-04 | 2016-12-08 | Epstein Alan L | Lym-1 and lym-2 targeted car cell immunotherapy |
WO2016193969A2 (en) | 2015-05-29 | 2016-12-08 | Opko Biologics Ltd. | Pegylated oxyntomodulin variants |
WO2016199140A1 (en) | 2015-06-08 | 2016-12-15 | Adicet Bio Inc. | T cell receptor like antibodies having fine specificity |
US9522945B2 (en) | 2012-04-19 | 2016-12-20 | Opko Biologics Ltd. | Long-acting oxyntomodulin variants and methods of producing same |
WO2016203482A2 (en) | 2015-06-19 | 2016-12-22 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
WO2016203477A1 (en) | 2015-06-18 | 2016-12-22 | Yeda Research And Development Co. Ltd. | Conditioning protocols and use of same for tissue regeneration |
WO2016203476A1 (en) | 2015-06-18 | 2016-12-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and compositions for diagnosing and treating urothelial cancer |
WO2016207402A1 (en) | 2015-06-26 | 2016-12-29 | Institute For Research In Biomedicine | Proteins comprising a mutated lair-1 fragment and uses thereof |
US9540642B2 (en) | 2013-11-04 | 2017-01-10 | The United States Of America, As Represented By The Secretary Of Agriculture | Compositions and methods for controlling arthropod parasite and pest infestations |
EP3115451A1 (en) | 2008-09-02 | 2017-01-11 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
WO2017009842A2 (en) | 2015-07-16 | 2017-01-19 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
WO2017009853A1 (en) | 2015-07-16 | 2017-01-19 | Yeda Research And Development Co. Ltd. | Genetically modified anti-third party central memory t cells and use of same in immunotherapy |
US9551006B2 (en) | 2010-12-22 | 2017-01-24 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for improving plant properties |
WO2017013661A1 (en) | 2015-07-22 | 2017-01-26 | Phytopharma International Ltd. | Bee-ingestible compositions, methods of using same for producing honey and honey produced thereby |
US9556210B2 (en) | 2007-04-23 | 2017-01-31 | Sabag-Rfa Ltd. | System for delivering therapeutic agents into living cells and cells nuclei |
WO2017017686A1 (en) | 2015-07-29 | 2017-02-02 | Hadasit Medical Research Services And Development Ltd. | Large scale production of retinal pigment epithelial cells |
WO2017021963A1 (en) | 2015-08-03 | 2017-02-09 | Biokine Therapeutics Ltd. | Cxcr4 binding agents for treatment of diseases |
WO2017021973A1 (en) | 2015-08-05 | 2017-02-09 | Cell Cure Neurosciences Ltd. | Preparation of retinal pigment epithelium cells |
WO2017021972A1 (en) | 2015-08-05 | 2017-02-09 | Cell Cure Neurosciences Ltd. | Preparation of photoreceptors for the treatment of retinal diseases |
WO2017021961A1 (en) | 2015-08-04 | 2017-02-09 | Yeda Research And Development Co. Ltd. | Methods of screening for riboswitches and attenuators |
US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
US9567579B2 (en) | 2003-05-23 | 2017-02-14 | Board Of Regents, The University Of Texas System | Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting AP-1 transcription factors |
WO2017025963A1 (en) | 2015-08-10 | 2017-02-16 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Methods and pharmaceutical compositions for improving wound healing using cd24 |
WO2017025967A1 (en) | 2015-08-13 | 2017-02-16 | Forrest Innovations Ltd. | Formulations and compositions for delivery of nucleic acids to plant cells |
WO2017033188A1 (en) | 2015-08-24 | 2017-03-02 | Yeda Research And Development Co. Ltd. | Algal oil and biofuel and methods of producing same |
WO2017042814A1 (en) | 2015-09-10 | 2017-03-16 | Yeda Research And Development Co. Ltd. | Use of perforin positive immature dendritic cells in disease treatment |
EP3159405A1 (en) | 2010-01-05 | 2017-04-26 | Vascular Biogenics Ltd. | Methods for use of a specific anti-angiogenic adenoviral agent |
WO2017072757A1 (en) | 2015-10-25 | 2017-05-04 | Yeda Research And Development Co. Ltd. | Antibodies targeting quiescin sulfhydryl oxidase (qsox1) and uses of same |
WO2017072772A1 (en) | 2015-10-29 | 2017-05-04 | Yeda Research And Development Co. Ltd. | A method of inducing cardiomyocytes proliferation and treating heart diseases |
WO2017072773A1 (en) | 2015-10-27 | 2017-05-04 | Ilana Nathan | Compositions comprising cannabidiol and second therapeutic agents for the treatment of cancer |
WO2017072763A1 (en) | 2015-10-26 | 2017-05-04 | Cell Cure Neurosciences Ltd. | Preparation of retinal pigment epithelium cells |
WO2017077539A1 (en) | 2015-11-03 | 2017-05-11 | Ariel-University Research And Development Company Ltd. | Compositions for regeneration and repair of neural tissue |
WO2017081689A1 (en) | 2015-11-11 | 2017-05-18 | Ramot At Tel-Aviv University Ltd. | Methods of detecting 5-hydroxymethylcytosine and diagnosing of cancer |
US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
EP3176183A1 (en) | 2015-12-02 | 2017-06-07 | Yeda Research and Development Co. Ltd | Compositions and methods for treating cancer not resistant to a tyrosine kinase inhibitor (tki) |
WO2017094001A1 (en) | 2015-11-30 | 2017-06-08 | Kadimastem Ltd | Methods for differentiating and purifying pancreatic endocrine cells |
WO2017118985A1 (en) | 2016-01-06 | 2017-07-13 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating malignant, autoimmune and inflammatory diseases |
WO2017122203A1 (en) | 2016-01-11 | 2017-07-20 | Technion Research & Development Foundation Limited | Methods of determining prognosis of sepsis and treating same |
WO2017125931A1 (en) | 2016-01-21 | 2017-07-27 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Parthenocarpic plants and methods of producing same |
WO2017130205A1 (en) | 2016-01-31 | 2017-08-03 | Hadasit Medical Research Services And Development Ltd. | Autosomal-identical pluripotent stem cell populations having non-identical sex chromosomal composition and uses thereof |
US9726581B2 (en) | 2011-12-22 | 2017-08-08 | Realbio Technologies Ltd. | Sequential lateral flow capillary device for analyte determination |
WO2017134671A1 (en) | 2016-02-04 | 2017-08-10 | Yeda Research And Development Co. Ltd. | Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant p53 |
WO2017138008A2 (en) | 2016-02-14 | 2017-08-17 | Yeda Research And Development Co. Ltd. | Methods of modulating protein exocytosis and uses of same in therapy |
WO2017138007A1 (en) | 2016-02-14 | 2017-08-17 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Microbiome-based diagnosis, prediction and treatment of relapsing obesity |
WO2017141253A1 (en) | 2016-02-16 | 2017-08-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Non-protein phenylalanine analogues for inhibiting cyanobacteria and plant growth |
WO2017145162A1 (en) | 2016-02-23 | 2017-08-31 | Chaya Brodie | Generation of cancer stem cells and use thereof |
WO2017149547A1 (en) | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Analyzing rna for diagnosing infection type |
WO2017153982A1 (en) | 2016-03-06 | 2017-09-14 | Yeda Research And Development Co. Ltd. | Method for modulating myelination |
WO2017158610A1 (en) | 2016-03-17 | 2017-09-21 | Yeda Research And Development Co. Ltd. | Methods of isolating barrel-like proteases and identifying peptides processed thereby |
US9777288B2 (en) | 2013-07-19 | 2017-10-03 | Monsanto Technology Llc | Compositions and methods for controlling leptinotarsa |
WO2017189746A1 (en) | 2016-04-27 | 2017-11-02 | Gen-Probe Incorporated | Blood cell lysis reagent |
US9808534B2 (en) | 2012-11-20 | 2017-11-07 | Opko Biologics Ltd. | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
EP3244189A1 (en) | 2008-12-30 | 2017-11-15 | Jin Po Lee | Quantitative analyte assay device and method |
US9822134B2 (en) | 2012-10-22 | 2017-11-21 | Sabag-Rfa Ltd. | System for delivering therapeutic agents into living cells and cells nuclei |
US9828417B2 (en) | 2006-02-03 | 2017-11-28 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
WO2017203520A1 (en) | 2016-05-22 | 2017-11-30 | Yeda Research And Development Co. Ltd. | Methods of using pulmonary cells for transplantation and induction of tolerance |
WO2017203532A1 (en) | 2016-05-25 | 2017-11-30 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Agents for use treating drug resistant tumors and triple negative breast cancer |
WO2017208247A1 (en) | 2016-06-02 | 2017-12-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Assay for the removal of methyl-cytosine residues from dna |
WO2017212476A1 (en) | 2016-06-05 | 2017-12-14 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Novel molecules for the treatment of inflammation |
WO2017212494A1 (en) | 2016-06-09 | 2017-12-14 | Opko Biologics Ltd. | Long-acting oxyntomodulin formulation and methods of producing and administering same |
US9850496B2 (en) | 2013-07-19 | 2017-12-26 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
WO2017221225A1 (en) | 2016-06-19 | 2017-12-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Screening for chemotherapy resistance in human haploid cells |
EP3263127A1 (en) | 2011-05-23 | 2018-01-03 | Yeda Research and Development Co. Ltd | Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same |
WO2018002924A1 (en) | 2016-06-27 | 2018-01-04 | Yeda Research And Development Co. Ltd. | Veto cells generated from memory t cells |
WO2018011799A1 (en) | 2016-07-11 | 2018-01-18 | Opko Biologics Ltd. | Long-acting coagulation factor vii and methods of producing same |
WO2018011283A1 (en) | 2016-07-13 | 2018-01-18 | Humabs Biomed Sa | Novel antibodies specifically binding to zika virus epitopes and uses thereof |
WO2018011805A2 (en) | 2016-07-11 | 2018-01-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Systems and methods for growing cells in vitro |
WO2018011796A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Early diagnosis of infections |
WO2018011804A1 (en) | 2016-07-11 | 2018-01-18 | Bonus Therapeutics Ltd. | Cell compositions for tissue regeneration |
WO2018011795A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
WO2018011806A1 (en) | 2016-07-11 | 2018-01-18 | Yeda Research And Development Co. Ltd. | Combination therapy to increase endogenous nitric oxide (no) synthesis |
WO2018020489A1 (en) | 2016-07-24 | 2018-02-01 | Yeda Research And Development Co. Ltd. | Methods and kits for analyzing dna binding moieties attached to dna |
US9884901B2 (en) | 2006-02-03 | 2018-02-06 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
WO2018029682A1 (en) | 2016-08-08 | 2018-02-15 | Ramot At Tel-Aviv University Ltd. | Bacterial systems for analyzing ubiquitylated polypeptides |
WO2018029690A1 (en) | 2016-08-10 | 2018-02-15 | Memed Diagnostics Ltd. | System and method for analysis of biological data |
WO2018033911A1 (en) | 2016-08-14 | 2018-02-22 | Ramot At Tel-Aviv University Ltd. | Mesenchymal cell-derived exosomes to treat neurological disorders |
WO2018033929A1 (en) | 2016-08-18 | 2018-02-22 | Yeda Research And Development Co. Ltd. | Diagnostic and therapeutic uses of exosomes |
WO2018037416A1 (en) | 2016-08-25 | 2018-03-01 | Yeda Research And Development Co. Ltd. | Methods and compositions for treating autoimmune diseases |
WO2018047154A1 (en) | 2016-09-07 | 2018-03-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Anti-nkp46 antibodies and therapeutic use of same |
WO2018051347A1 (en) | 2016-09-14 | 2018-03-22 | Yeda Research And Development Co. Ltd. | Crisp-seq, an integrated method for massively parallel single cell rna-seq and crispr pooled screens |
US9925143B2 (en) | 2012-04-18 | 2018-03-27 | Ramot At Tel-Aviv University Ltd. | Lipidated glycosaminoglycan particles for the delivery of nucleic acids |
WO2018060998A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
US9938316B2 (en) | 2013-08-29 | 2018-04-10 | Yeda Research And Development Co. Ltd. | Selective inhibitors of α2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents |
WO2018069885A1 (en) | 2016-10-13 | 2018-04-19 | Technion Research & Development Foundation Limited | Use of caspase-3 inhibitors and caspase-3 activators in the manufacture of medicament for treating cancer and wound healing |
US9952211B2 (en) | 2008-06-29 | 2018-04-24 | Realbio Technologies Ltd. | Liquid-transfer device particularly useful as a capturing device in a biological assay process |
WO2018073823A2 (en) | 2016-10-18 | 2018-04-26 | Yeda Research And Development Co. Ltd. | Treatment of a circadian rhythm disorder |
WO2018087759A1 (en) | 2016-11-10 | 2018-05-17 | Yeda Research And Development Co. Ltd. | Phosphotriesterases for treating or preventing organophosphate exposure associated damage |
WO2018096547A1 (en) | 2016-11-28 | 2018-05-31 | Yeda Research And Development Co. Ltd. | Isolated polynucleotides and polypeptides and methods of using same for expressing an expression product of interest |
WO2018100511A1 (en) | 2016-12-01 | 2018-06-07 | Ramot At Tel-Aviv University Ltd. | Combined treatment for nerve injuries |
WO2018100574A1 (en) | 2016-11-30 | 2018-06-07 | Yeda Research And Development Co. Ltd. | Methods of treating liver toxicity and disorders |
WO2018134824A1 (en) | 2017-01-18 | 2018-07-26 | Yeda Research And Development Co. Ltd. | Genetically modified veto cells and use of same in immunotherapy |
EP3354723A1 (en) | 2005-08-29 | 2018-08-01 | Technion Research & Development Foundation Ltd. | Media for culturing stem cells |
WO2018142416A1 (en) | 2017-02-06 | 2018-08-09 | Yeda Research And Development Co. Ltd. | Isolated cells genetically modified to express a disarm system having an anti-phage activity and methods of producing same |
EP3366762A1 (en) | 2007-05-07 | 2018-08-29 | Protalix Ltd. | Large scale disposable bioreactor |
WO2018158775A1 (en) | 2017-03-02 | 2018-09-07 | Yeda Research And Development Co. Ltd. | Methods of culturing t cells and uses of same |
WO2018167778A1 (en) | 2017-03-12 | 2018-09-20 | Yeda Research And Development Co. Ltd. | Methods of diagnosing and prognosing cancer |
WO2018170494A1 (en) | 2017-03-16 | 2018-09-20 | Bio Time, Inc. | Methods for measuring therapeutic effects of retinal disease therapies |
WO2018167780A1 (en) | 2017-03-12 | 2018-09-20 | Yeda Research And Development Co. Ltd. | Methods of prognosing and treating cancer |
US10080799B2 (en) | 2010-02-12 | 2018-09-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions related to glycoprotein-immunoglobulin fusions |
WO2018185760A1 (en) | 2017-04-05 | 2018-10-11 | Yeda Research And Development Co. Ltd. | Ex-vivo culture system and methods of using same |
WO2018193063A2 (en) | 2017-04-19 | 2018-10-25 | Institute For Research In Biomedicine | Novel malaria vaccines and antibodies binding to plasmodium sporozoites |
WO2018207178A1 (en) | 2017-05-07 | 2018-11-15 | Yeda Research And Development Co. Ltd. | Methods of treating psychiatric stress disorders |
WO2018207184A2 (en) | 2017-05-10 | 2018-11-15 | Ariel Scientific Innovations Ltd. | Methods of purifying antibodies |
WO2018216006A1 (en) | 2017-05-21 | 2018-11-29 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Combination of markers for diagnosing cancer |
WO2018216011A1 (en) | 2017-05-23 | 2018-11-29 | Technion Research & Development Foundation Limited | Agents which inhibit gads dimerization and methods of use thereof |
WO2018220582A1 (en) | 2017-05-31 | 2018-12-06 | Tropic Biosciences UK Limited | Methods of selecting cells comprising genome editing events |
WO2018220581A1 (en) | 2017-05-31 | 2018-12-06 | Tropic Biosciences UK Limited | Compositions and methods for increasing shelf-life of banana |
WO2018220579A1 (en) | 2017-05-31 | 2018-12-06 | Tropic Biosciences UK Limited | Compositions and methods for increasing extractability of solids from coffee beans |
WO2018229764A1 (en) | 2017-06-13 | 2018-12-20 | Yeda Research And Development Co. Ltd. | Treatment of advanced or progressive multiple sclerosis |
US10166295B2 (en) | 2011-06-02 | 2019-01-01 | Opko Biologics Ltd. | Pegylated OXM variants |
WO2019012544A1 (en) | 2017-07-13 | 2019-01-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Dual-probe digital droplet pcr strategy for specific detection of tissue-specific circulating dna molecules |
WO2019012542A1 (en) | 2017-07-13 | 2019-01-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Detecting tissue-specific dna |
WO2019012543A1 (en) | 2017-07-13 | 2019-01-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Dna targets as tissue-specific methylation markers |
US10184131B2 (en) | 2012-02-06 | 2019-01-22 | A.B. Seeds Ltd. | Isolated polynucleotides expressing or modulating microRNAs or targets of same, transgenic plants comprising same and uses thereof |
WO2019021284A1 (en) | 2017-07-24 | 2019-01-31 | Yeda Research And Development Co. Ltd. | Combination therapy for the treatment of cancer |
WO2019035128A1 (en) | 2017-08-14 | 2019-02-21 | Yeda Research And Development Co. Ltd. | Immunotherapy against transferrin receptor 1 (tfr1)-tropic arenaviruses |
WO2019038771A1 (en) | 2017-08-23 | 2019-02-28 | Technion Research & Development Foundation Limited | Compositions and methods for improving alcohol tolerance in yeast |
US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
WO2019042555A1 (en) | 2017-08-31 | 2019-03-07 | Humabs Biomed Sa | Multispecific antibodies specifically binding to zika virus epitopes and uses thereof |
WO2019094595A2 (en) | 2017-11-09 | 2019-05-16 | Pinteon Therapeutics Inc. | Methods and compositions for the generation and use of humanized conformation-specific phosphorylated tau antibodies |
US10294292B2 (en) | 2014-07-15 | 2019-05-21 | Medimmune, Llc | Neutralizing anti-influenza B antibodies and uses thereof |
WO2019097514A1 (en) | 2017-11-14 | 2019-05-23 | Yeda Research And Development Co. Ltd. | Hematopoietic stem cells with improved properties |
WO2019106671A1 (en) | 2017-11-29 | 2019-06-06 | Ramot At Tel-Aviv University Ltd. | Methods of preventing or treating neurogenic shock |
WO2019106680A1 (en) | 2017-12-03 | 2019-06-06 | Yeda Research And Development Co. Ltd. | Treatment of an ischemic heart disease |
WO2019106667A1 (en) | 2017-11-29 | 2019-06-06 | Weedout Ltd. | Compositions, kits and methods for controlling weed of the amaranthus genus |
WO2019116376A1 (en) | 2017-12-17 | 2019-06-20 | Yeda Research And Development Co. Ltd. | Cop9 signalosome (csn) complex modulators and uses thereof |
US10335783B2 (en) | 2005-01-31 | 2019-07-02 | Realbio Technologies, Ltd. | Multistep reaction lateral flow capillary device |
US10334848B2 (en) | 2014-01-15 | 2019-07-02 | Monsanto Technology Llc | Methods and compositions for weed control using EPSPS polynucleotides |
WO2019130313A1 (en) | 2017-12-28 | 2019-07-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method to reproduce circadian rhythms on a microfluidic chip |
US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
US10359573B2 (en) | 1999-11-05 | 2019-07-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-granting devices and methods for using same |
WO2019145964A1 (en) | 2018-01-29 | 2019-08-01 | Yeda Research And Development Co. Ltd. | Combination of a mek inhibitor and a cdk4/6 inhibitor for the treatment of sarcoma |
WO2019150373A1 (en) | 2018-01-31 | 2019-08-08 | Yeda Research And Development Co. Ltd. | Endoplasmic reticulum targeting signal |
US10378012B2 (en) | 2014-07-29 | 2019-08-13 | Monsanto Technology Llc | Compositions and methods for controlling insect pests |
WO2019155459A1 (en) | 2018-02-08 | 2019-08-15 | Yeda Research And Development Co. Ltd. | Inhibitors of the 20s proteasome |
WO2019155465A1 (en) | 2018-02-08 | 2019-08-15 | Yeda Research And Development Co. Ltd. | Methods of identifying and using agents for treating diseases associated with intestinal barrier dysfunction |
WO2019167047A1 (en) | 2018-02-28 | 2019-09-06 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Methods of diagnosing and treating bladder cancer |
WO2019175869A1 (en) | 2018-03-12 | 2019-09-19 | Yeda Research And Development Co. Ltd | Treatment of a heart disease |
US10421785B2 (en) | 2016-04-11 | 2019-09-24 | Bar-Ilan University | Delta receptor agonist peptides and use thereof |
WO2019186570A1 (en) | 2018-03-29 | 2019-10-03 | Yeda Research And Development Co. Ltd. | Methods of disrupting a biofilm and/or preventing formation of same |
WO2019186569A1 (en) | 2018-03-29 | 2019-10-03 | Yeda Research And Development Co. Ltd. | Use of electric field gradients to control gene expression |
US10442854B2 (en) | 2015-06-01 | 2019-10-15 | Medimmune, Llc | Neutralizing anti-influenza binding molecules and uses thereof |
US10457954B2 (en) | 2010-08-30 | 2019-10-29 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance |
WO2019211750A1 (en) | 2018-05-01 | 2019-11-07 | Tropic Biosciences UK Limited | Compositions and methods for reducing caffeine content in coffee beans |
WO2019220441A1 (en) | 2018-05-15 | 2019-11-21 | Hadasit Medical Research Services And Development Ltd. | Compositions and methods for treating cancer resistant to an anti-cancer agent |
WO2019220437A1 (en) | 2018-05-15 | 2019-11-21 | Yeda Research And Development Co. Ltd. | Vaccination with cancer neoantigens |
US10494419B2 (en) | 2013-10-02 | 2019-12-03 | Medimmune, Llc | Neutralizing anti-influenza A antibodies and uses thereof |
WO2019229745A1 (en) | 2018-05-27 | 2019-12-05 | Biolinerx Ltd. | Agi-134 combined with a checkpoint inhibitor for the treatment of solid tumors |
WO2019234750A1 (en) | 2018-06-07 | 2019-12-12 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Methods of regenerating and transforming cannabis |
WO2019234754A1 (en) | 2018-06-07 | 2019-12-12 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Nucleic acid constructs and methods of using same |
WO2020003311A1 (en) | 2018-06-25 | 2020-01-02 | Yeda Research And Development Co. Ltd. | Systems and methods for increasing efficiency of genome editing |
WO2020008412A1 (en) | 2018-07-04 | 2020-01-09 | Ukko Inc. | Methods of de-epitoping wheat proteins and use of same for the treatment of celiac disease |
WO2020012486A1 (en) | 2018-07-11 | 2020-01-16 | Kahr Medical Ltd. | SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF |
WO2020012478A2 (en) | 2018-07-11 | 2020-01-16 | Immunity Pharma Ltd. | Peptide compounds and therapeutic uses of same |
WO2020012467A2 (en) | 2018-07-08 | 2020-01-16 | Yeda Research And Development Co. Ltd. | Person-specific assessment of probiotics responsiveness |
US10550439B2 (en) | 2014-07-21 | 2020-02-04 | Novellusdx Ltd. | Methods for determining drug response of patient specific mutations |
US10550196B2 (en) | 2014-04-27 | 2020-02-04 | Famewave Ltd. | Humanized antibodies against CEACAM1 |
WO2020026241A1 (en) | 2018-07-31 | 2020-02-06 | Collplant Ltd. | Tobacco transgenic event and methods for detection and use thereof |
US10557138B2 (en) | 2013-12-10 | 2020-02-11 | Beeologics, Inc. | Compositions and methods for virus control in Varroa mite and bees |
US10561706B2 (en) | 2015-12-28 | 2020-02-18 | B. G. Negev Technologies And Applications | Isolated polypeptide and compositions comprising same |
WO2020035863A1 (en) | 2018-08-14 | 2020-02-20 | Yeda Research And Development Co. Ltd. | Chimeric quiescin sulfhydryl oxidase (qsox1) antibodies and uses of same |
US10568328B2 (en) | 2013-03-15 | 2020-02-25 | Monsanto Technology Llc | Methods and compositions for weed control |
WO2020041360A1 (en) | 2018-08-21 | 2020-02-27 | Quidel Corporation | Dbpa antibodies and uses thereof |
WO2020039440A1 (en) | 2018-08-24 | 2020-02-27 | Yeda Research And Development Co. Ltd. | Methods of modulating m2 macrophage polarization and use of same in therapy |
US10577412B2 (en) | 2015-04-12 | 2020-03-03 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Anti-plasmodium parasite antibodies |
US10583084B2 (en) | 2014-06-26 | 2020-03-10 | Ramot At Tel-Aviv University Ltd. | Liposomal formulations for delivery of nucleic acids |
WO2020058979A2 (en) | 2018-09-20 | 2020-03-26 | Yeda Research And Development Co. Ltd. | Methods of treating amyotrophic lateral sclerosis |
WO2020065647A1 (en) | 2018-09-25 | 2020-04-02 | Biolinerx Ltd. | Methods of selecting treatment for cxcr4-associated cancer |
US10612019B2 (en) | 2013-03-13 | 2020-04-07 | Monsanto Technology Llc | Methods and compositions for weed control |
US10609930B2 (en) | 2013-03-13 | 2020-04-07 | Monsanto Technology Llc | Methods and compositions for weed control |
EP3633025A1 (en) | 2009-11-12 | 2020-04-08 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
WO2020089892A1 (en) | 2018-10-28 | 2020-05-07 | Yeda Research And Development Co. Ltd. | Prevention of age related clonal hematopoiesis and diseases associated therewith |
US10655136B2 (en) | 2015-06-03 | 2020-05-19 | Monsanto Technology Llc | Methods and compositions for introducing nucleic acids into plants |
US10662226B2 (en) | 2016-10-28 | 2020-05-26 | The Regents of the University of Caiifomia | Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers |
WO2020105050A2 (en) | 2018-11-21 | 2020-05-28 | Yeda Research And Development Co. Ltd. | Method of treating cancer and compositions for same |
US10668094B2 (en) | 2015-07-19 | 2020-06-02 | Yeda Research And Development Co. Ltd. | Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure |
US10683363B2 (en) | 2012-03-30 | 2020-06-16 | The United States Of America As Represented By The Department Of Veteran Affairs | Targeting intracellular target-binding determinants with intracellular antibodies |
US10683505B2 (en) | 2013-01-01 | 2020-06-16 | Monsanto Technology Llc | Methods of introducing dsRNA to plant seeds for modulating gene expression |
US10683344B2 (en) | 2015-10-07 | 2020-06-16 | Humabs Biomed Sa | Antibodies that potently neutralize hepatitis B virus and uses thereof |
WO2020132091A2 (en) | 2018-12-19 | 2020-06-25 | Humabs Biomed Sa | Antibodies that neutralize hepatitis b virus and uses thereof |
WO2020152686A1 (en) | 2019-01-23 | 2020-07-30 | Yeda Research And Development Co. Ltd. | Culture media for pluripotent stem cells |
WO2020161724A1 (en) | 2019-02-10 | 2020-08-13 | Yeda Research And Development Co. Ltd. | Anti-matrix metalloproteinase 7 (mmp-7) inhibitory antibody and uses thereof |
WO2020165907A1 (en) | 2019-02-14 | 2020-08-20 | Yeda Research And Development Co. Ltd. | Spt5 inhibitors and uses thereof |
WO2020170240A1 (en) | 2019-02-21 | 2020-08-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method for reduction drug-induced nephrotoxicity |
WO2020170239A1 (en) | 2019-02-21 | 2020-08-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of generating organoids for high throughput screening of drugs |
US10760086B2 (en) | 2011-09-13 | 2020-09-01 | Monsanto Technology Llc | Methods and compositions for weed control |
US10760088B2 (en) | 2011-05-03 | 2020-09-01 | Evogene Ltd. | Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency |
US10765706B2 (en) | 2015-09-03 | 2020-09-08 | University Of South Florida | Method of stem cell delivery into the brain during chronic disease using blood brain barrier permeabilizers |
WO2020178822A1 (en) | 2019-03-05 | 2020-09-10 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Genome-edited birds |
WO2020183416A1 (en) | 2019-03-14 | 2020-09-17 | Tropic Biosciences UK Limited | PRODUCTION OF dsRNA IN PLANT CELLS FOR PEST PROTECTION VIA GENE SILENCING |
WO2020183414A2 (en) | 2019-03-14 | 2020-09-17 | Tropic Biosciences UK Limited | Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells |
WO2020183419A1 (en) | 2019-03-14 | 2020-09-17 | Tropic Biosciences UK Limited | Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest |
WO2020188572A1 (en) | 2019-03-19 | 2020-09-24 | Yeda Research And Development Co. Ltd. | Bistable type ii opsins and uses thereof |
WO2020194317A1 (en) | 2019-03-28 | 2020-10-01 | Yeda Research And Development Co. Ltd. | Method of treating lipid-related disorders |
WO2020193718A1 (en) | 2019-03-27 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant proteins with cd40 activating properties |
WO2020202142A2 (en) | 2019-03-31 | 2020-10-08 | Yeda Research And Development Co. Ltd. | Anti-viral and anti-tumoral compounds |
US10806146B2 (en) | 2011-09-13 | 2020-10-20 | Monsanto Technology Llc | Methods and compositions for weed control |
US10808249B2 (en) | 2011-09-13 | 2020-10-20 | Monsanto Technology Llc | Methods and compositions for weed control |
WO2020222241A1 (en) | 2019-05-02 | 2020-11-05 | Yeda Research And Development Co. Ltd. | Compositions comprising the propeptide of lysyl oxidase and uses thereof |
US10829828B2 (en) | 2011-09-13 | 2020-11-10 | Monsanto Technology Llc | Methods and compositions for weed control |
WO2020230133A1 (en) | 2019-05-13 | 2020-11-19 | Yeda Research And Development Co. Ltd. | Cell-free mirna biomarkers for prognosis and diagnosis of neurodegenerative diseases |
WO2020234888A1 (en) | 2019-05-22 | 2020-11-26 | Hadasit Medical Research Services And Development Ltd. | Methods of culturing human pluripotent cells |
WO2020234875A2 (en) | 2019-05-19 | 2020-11-26 | Yeda Research And Development Co. Ltd. | Identification of recurrent mutated neopeptides |
WO2020237491A1 (en) | 2019-05-28 | 2020-12-03 | Shanghaitech University | Composition and methods to treat ectodermal dysplasia 2, clouston type |
WO2020250232A1 (en) | 2019-06-12 | 2020-12-17 | Hadasit Medical Research Services And Development Ltd. | Methods of generating oligodendrocytes |
WO2020255124A1 (en) | 2019-06-16 | 2020-12-24 | Yeda Research And Development Co. Ltd. | Method for stabilizing intracellular rna |
WO2020261281A1 (en) | 2019-06-27 | 2020-12-30 | Ramot At Tel-Aviv University Ltd. | Semaphorin 3a antibodies and uses thereof |
US10883103B2 (en) | 2015-06-02 | 2021-01-05 | Monsanto Technology Llc | Compositions and methods for delivery of a polynucleotide into a plant |
WO2021001784A1 (en) | 2019-07-04 | 2021-01-07 | Ukko Inc. | De-epitoped alpha gliadin and use of same for the management of celiac disease and gluten sensitivity |
WO2021005599A1 (en) | 2019-07-11 | 2021-01-14 | Kahr Medical Ltd. | Heterodimers and methods of use thereof |
WO2021009763A1 (en) | 2019-07-16 | 2021-01-21 | Yeda Research And Development Co. Ltd. | Methods of treating pain |
WO2021009740A1 (en) | 2019-07-16 | 2021-01-21 | Ramot At Tel-Aviv University Ltd. | Compositions and methods for the treatment of tuberculosis |
US10906987B2 (en) | 2016-03-01 | 2021-02-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies specific to human poliovirus receptor (PVR) |
WO2021019536A1 (en) | 2019-07-30 | 2021-02-04 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby |
WO2021019526A1 (en) | 2019-07-29 | 2021-02-04 | Yeda Research And Development Co. Ltd. | Methods of treating and diagnosing lung cancer |
WO2021028909A1 (en) | 2019-08-12 | 2021-02-18 | Yeda Research And Development Co. Ltd. | Dna repair blood test for predicting response of lung cancer patients to immunotherapy |
WO2021033176A1 (en) | 2019-08-22 | 2021-02-25 | Ariel Scientific Innovations Ltd. | Scaled-up methods for purifying antibodies |
WO2021038569A1 (en) | 2019-08-27 | 2021-03-04 | Yeda Research And Development Co. Ltd. | Treatment of bacterial vaginosis |
WO2021042000A1 (en) | 2019-08-29 | 2021-03-04 | Vir Biotechnology, Inc. | Antibody compositions and methods for treating hepatitis b virus infection |
WO2021048852A1 (en) | 2019-09-11 | 2021-03-18 | Yeda Research And Development Co. Ltd. | Methods of treating breast cancer |
US10954313B2 (en) | 2016-01-28 | 2021-03-23 | Sp Nano Ltd. | Composition comprising SP1 and carbon based nanoparticles and uses thereof |
US10964443B2 (en) | 2016-01-28 | 2021-03-30 | Sp Nano Ltd. | Conductive yarn |
WO2021059269A1 (en) | 2019-09-25 | 2021-04-01 | Yeda Research And Development Co. Ltd. | Assembly of protein complexes on a chip |
US10968449B2 (en) | 2015-01-22 | 2021-04-06 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
US10988764B2 (en) | 2014-06-23 | 2021-04-27 | Monsanto Technology Llc | Compositions and methods for regulating gene expression via RNA interference |
US10993990B2 (en) | 2014-05-16 | 2021-05-04 | Baylor Research Institute | Methods and compositions for treating autoimmune and inflammatory conditions |
WO2021084526A1 (en) | 2019-10-31 | 2021-05-06 | Yeda Research And Development Co. Ltd. | Engineered autotrophic bacteria for co2 conversion to organic materials |
WO2021084540A1 (en) | 2019-10-30 | 2021-05-06 | Yeda Research And Development Co. Ltd. | Inhibitors of mmej pathway for prevention and treatment of pre-myeloid and myeloid malignancies |
WO2021095031A2 (en) | 2019-11-11 | 2021-05-20 | Ibi-Ag Innovative Bio Insecticides Ltd. | Insect control nanobodies and uses thereof |
US11015229B2 (en) | 2014-07-21 | 2021-05-25 | Novellusdx Ltd. | Methods and systems for determining oncogenic index of patient specific mutations |
WO2021100041A1 (en) | 2019-11-20 | 2021-05-27 | Yeda Research And Development Co. Ltd. | Treating alzheimer's disease |
WO2021099576A1 (en) | 2019-11-21 | 2021-05-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Novel immunotherapies targeting pd-1 with anti-pd-1/il-15 immunocytokines |
WO2021100034A1 (en) | 2019-11-19 | 2021-05-27 | Protalix Ltd. | Removal of constructs from transformed cells |
EP3831404A1 (en) | 2014-11-18 | 2021-06-09 | Humabs Biomed S.A. | Antibodies that potently neutralize rabies virus and other lyssaviruses and uses thereof |
WO2021110126A1 (en) | 2019-12-04 | 2021-06-10 | 珠海泰诺麦博生物技术有限公司 | Antibody against human cytomegalovirus and use thereof |
WO2021130753A1 (en) | 2019-12-22 | 2021-07-01 | Yeda Research And Development Co. Ltd. | Diagnosis of frontotemporal dementia |
WO2021130752A1 (en) | 2019-12-22 | 2021-07-01 | Yeda Research And Development Co. Ltd. | Systems and methods for identifying cells that have undergone genome editing |
WO2021137231A1 (en) | 2019-12-31 | 2021-07-08 | Kahr Medical Ltd. | Methods of culturing t cells with a 4-1bbl fusion polypeptide and uses of same |
WO2021137230A1 (en) | 2019-12-31 | 2021-07-08 | Kahr Medical Ltd. | Methods of culturing t cells and uses of same |
WO2021137222A1 (en) | 2019-12-31 | 2021-07-08 | Ichilov Tech Ltd. | Methods of treating atopic dermatitis |
WO2021144798A1 (en) | 2020-01-15 | 2021-07-22 | Immunity Pharma Ltd. | Peptide compounds and methods of treating diseases using same |
WO2021149053A1 (en) | 2020-01-22 | 2021-07-29 | Yeda Research And Development Co. Ltd. | Multispecific antibodies for use in treating diseases |
WO2021152592A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Methods of treating cancer |
WO2021152586A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Methods of analyzing microbiome, immunoglobulin profile and physiological state |
WO2021152590A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Articles of manufacture comprising anti pd-l1 antibodies and their use in therapy |
WO2021152584A1 (en) | 2020-01-28 | 2021-08-05 | Ariel Scientific Innovations Ltd. | Methods of analyzing cell membranes |
WO2021152587A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Treating acute liver disease with tlr-mik inhibitors |
WO2021156878A2 (en) | 2020-02-09 | 2021-08-12 | Nlc Pharma Ltd | Rapid detection test for sars-cov-2 |
US11091770B2 (en) | 2014-04-01 | 2021-08-17 | Monsanto Technology Llc | Compositions and methods for controlling insect pests |
WO2021161310A1 (en) | 2020-02-10 | 2021-08-19 | Yeda Research And Development Co. Ltd. | Method for analyzing cell clusters |
WO2021173674A1 (en) | 2020-02-26 | 2021-09-02 | A2 Biotherapeutics, Inc. | Polypeptides targeting mage-a3 peptide-mhc complexes and methods of use thereof |
WO2021178637A1 (en) | 2020-03-05 | 2021-09-10 | Iowa State University Research Foundation, Inc. | IMMUNOGENIC AND VACCINE COMPOSITIONS AGAINST SARS-CoV-2 |
WO2021186431A1 (en) | 2020-03-16 | 2021-09-23 | Yeda Research And Development Co. Ltd. | Peptide analogs and use of same in treating diseases, disorders or conditions associated with a mutant p53 protein |
WO2021199047A1 (en) | 2020-03-31 | 2021-10-07 | Biomuse Ltd. | Bacteria for the prevention and treatment of smoke-induced lung damage |
WO2021199039A1 (en) | 2020-03-29 | 2021-10-07 | Yeda Research And Development Co. Ltd. | Variants of beta-glucocerebrosidase for use in treating gaucher disease |
WO2021205444A1 (en) | 2020-04-06 | 2021-10-14 | Yeda Research And Development Co. Ltd. | Methods of diagnosing cancer and predicting responsiveness to therapy |
WO2021205459A1 (en) | 2020-04-07 | 2021-10-14 | Ramot At Tel-Aviv University Ltd. | Cannabidiol-containing compositions and uses thereof |
EP3895697A1 (en) | 2020-04-16 | 2021-10-20 | Ichilov Tech Ltd. | Cell-derived particles presenting heterologous cd24 and use thereof in therapy |
WO2021209995A1 (en) | 2020-04-13 | 2021-10-21 | Exoprother Medical Ltd. | Cell-derived vesicles comprising wild-type p53 protein for antiviral therapy |
GB202112865D0 (en) | 2021-09-09 | 2021-10-27 | Tropic Biosciences Uk Ltd | Resistance to black sigatoka disease in banana |
GB202112866D0 (en) | 2021-09-09 | 2021-10-27 | Tropic Biosciences Uk Ltd | Resistance to fusarium wilt in a banana |
WO2021228836A1 (en) | 2020-05-13 | 2021-11-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant proteins with ox40 activating properties |
WO2021229577A1 (en) | 2020-05-12 | 2021-11-18 | Collplant Ltd. | Collagen as a delivery tool for metal-based anti-viral agents |
WO2021234698A1 (en) | 2020-05-20 | 2021-11-25 | Yeda Research And Development Co. Ltd. | Indexing spatial information for a single-cell downstream applications |
US11197915B2 (en) | 2013-10-21 | 2021-12-14 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
WO2021260675A1 (en) | 2020-06-24 | 2021-12-30 | Yeda Research And Development Co. Ltd. | Agents for sensitizing solid tumors to treatment |
WO2021262840A1 (en) | 2020-06-24 | 2021-12-30 | Vir Biotechnology, Inc. | Engineered hepatitis b virus neutralizing antibodies and uses thereof |
WO2022034575A1 (en) | 2020-08-09 | 2022-02-17 | Yeda Research And Development Co. Ltd. | Mage-a1 specific t cell receptor and uses thereof |
WO2022034588A1 (en) | 2020-08-10 | 2022-02-17 | Yeda Research And Development Co. Ltd. | Compositions for diagnosis and treatment of coronavirus infections |
WO2022038536A1 (en) | 2020-08-18 | 2022-02-24 | International Rice Research Institute | Methods of increasing outcrossing rates in gramineae |
WO2022059015A1 (en) | 2020-09-21 | 2022-03-24 | Yeda Research And Development Co. Ltd. | Method for modulating weight |
WO2022064494A2 (en) | 2020-09-23 | 2022-03-31 | Yeda Research And Development Co. Ltd. | Methods and compositions for treating coronaviral infections |
WO2022070194A1 (en) | 2020-10-01 | 2022-04-07 | Yeda Research And Development Co. Ltd. | Method of diagnosing breast cancer |
WO2022074656A1 (en) | 2020-10-07 | 2022-04-14 | Protalix Ltd. | Long-acting dnase |
WO2022074646A1 (en) | 2020-10-05 | 2022-04-14 | Protalix Ltd. | Dicer-like knock-out plant cells |
WO2022079719A1 (en) | 2020-10-15 | 2022-04-21 | Yeda Research And Development Co. Ltd. | Method of treating myeloid malignancies |
WO2022091100A1 (en) | 2020-10-29 | 2022-05-05 | Yeda Research And Development Co. Ltd. | Polynucleotides for rna editing and methods of using same |
WO2022097157A2 (en) | 2020-11-09 | 2022-05-12 | 1E Therapeutics, Ltd. | Catalytic sequence based methods of treating or preventing bacterial infections |
WO2022115498A1 (en) | 2020-11-26 | 2022-06-02 | Ukko Inc. | Modified high molecular weight glutenin subunit and uses thereof |
WO2022130384A1 (en) | 2020-12-17 | 2022-06-23 | Yeda Research And Development Co. Ltd. | Controlling ubiquitination of mlkl for treatment of disease |
WO2022144883A2 (en) | 2020-12-28 | 2022-07-07 | 1E Therapeutics, Ltd. | P21 mrna targeting dnazymes |
WO2022144882A2 (en) | 2020-12-28 | 2022-07-07 | 1E Therapeutics, Ltd. | P21 mrna target areas for silencing |
WO2022149142A2 (en) | 2021-01-10 | 2022-07-14 | Supermeat The Essence Of Meat Ltd. | Pluripotent stem cell aggregates and microtissues obtained therefrom for the cultured meat industry |
WO2022153286A1 (en) | 2021-01-14 | 2022-07-21 | Yeda Research And Development Co. Ltd. | Methods of producing vitamin d |
WO2022157774A1 (en) | 2021-01-21 | 2022-07-28 | Yeda Research And Development Co. Ltd. | Antibodies, peptides and combinations of same for the treatment or prevention of coronavirus infection |
WO2022164805A1 (en) | 2021-01-26 | 2022-08-04 | Vir Biotechnology, Inc. | Compositions and methods for treating hepatitis b virus infection |
US11413336B2 (en) | 2018-03-23 | 2022-08-16 | Board Of Regents, The University Of Texas System | Coccidioides antigens and methods of their use |
WO2022175952A1 (en) | 2021-02-18 | 2022-08-25 | Yeda Research And Development Co. Ltd. | Method of generating vaccines |
WO2022175951A1 (en) | 2021-02-18 | 2022-08-25 | Yeda Research And Development Co. Ltd. | Genetically modified bacteria for generating vaccines |
US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
US11433163B2 (en) | 2014-04-10 | 2022-09-06 | Bonus Therapeutics Ltd. | Bone repair compositions |
WO2022189558A2 (en) | 2021-03-10 | 2022-09-15 | Mabylon Ag | Antibodies against tdp-43 and methods of using the same |
EP4059507A1 (en) | 2015-12-16 | 2022-09-21 | Ramot at Tel-Aviv University Ltd. | Particles comprising decellularized omentum |
WO2022195589A2 (en) | 2021-03-16 | 2022-09-22 | Yeda Research And Development Co. Ltd. | Methods and devices for ex-utero mouse embryonic development |
WO2022208369A1 (en) | 2021-03-30 | 2022-10-06 | Biomx Ltd. | Pseudomonas bacteriophage and uses thereof |
WO2022215080A1 (en) | 2021-04-08 | 2022-10-13 | Yeda Research And Development Co. Ltd. | A combined use of ketamine and retigabine (ezogabine) for the treatment of psychiatric disorders |
WO2022238947A1 (en) | 2021-05-12 | 2022-11-17 | Biomx Ltd. | Staphylococcus bacteriophage and uses thereof |
WO2022254430A1 (en) | 2021-05-30 | 2022-12-08 | Yeda Research And Development Co. Ltd. | Anti-microbial peptide (amp) signatures for diagnostics, stratification, and treatment of microbiome-associated disease |
WO2022259242A1 (en) | 2021-06-06 | 2022-12-15 | Yeda Research And Development Co. Ltd. | Combined treatment for cancer |
NL2028466B1 (en) | 2021-06-16 | 2022-12-21 | Sakata Holland B V | Methods of sorting matthiola seeds |
WO2022264132A1 (en) | 2021-06-13 | 2022-12-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method for reprogramming human cells |
WO2022264076A1 (en) | 2021-06-16 | 2022-12-22 | Seedx Technologies Inc. | Methods of sorting matthiola seeds |
WO2023275255A1 (en) | 2021-07-02 | 2023-01-05 | Tropic Biosciences UK Limited | Delay or prevention of browning in banana fruit |
US11547756B2 (en) | 2016-01-13 | 2023-01-10 | Medimmune, Llc | Method of treating influenza A |
US11555199B2 (en) | 2017-09-19 | 2023-01-17 | Tropic Biosciences UK Limited | Modifying the specificity of plant non-coding RNA molecules for silencing gene expression |
WO2023003809A1 (en) | 2021-07-18 | 2023-01-26 | Gamida-Cell Ltd. | Therapeutic nk cell populations |
WO2023002492A1 (en) | 2021-07-22 | 2023-01-26 | Yeda Research And Development Co. Ltd. | Codon optimization of nucleic acids |
US11571433B2 (en) | 2018-02-23 | 2023-02-07 | Carmel Haifa University Economic Corporation Ltd. | Methods for treating memory impairment and cognitive dysfunction |
EP4130028A1 (en) | 2021-08-03 | 2023-02-08 | Rhazes Therapeutics Ltd | Engineered tcr complex and methods of using same |
WO2023012584A2 (en) | 2021-08-03 | 2023-02-09 | Genicity Limited | Engineered tcr complex and methods of using same |
WO2023018621A1 (en) | 2021-08-10 | 2023-02-16 | Gamida-Cell Ltd. | Engineered nk cells, methods of their production and uses thereof |
WO2023042202A1 (en) | 2021-09-14 | 2023-03-23 | Yeda Research And Development Co. Ltd. | Multispecific antibodies for use in treating diseases |
US11648260B2 (en) | 2018-03-29 | 2023-05-16 | Technion Research And Development Foundation Limitted | Vesicles comprising a PTEN inhibitor and uses of same |
WO2023105526A1 (en) | 2021-12-08 | 2023-06-15 | Yeda Research And Development Co. Ltd. | Multipotent lung progenitor cells for lung regeneration |
EP4218771A1 (en) | 2015-03-27 | 2023-08-02 | Yeda Research and Development Co. Ltd | Methods of treating motor neuron diseases |
WO2023144779A1 (en) | 2022-01-28 | 2023-08-03 | Pfizer Inc. | Coronavirus antigen variants |
WO2023209708A1 (en) | 2022-04-25 | 2023-11-02 | Yeda Research And Development Co. Ltd. | Compositions for altering cyclic adp-ribose secondary messenger signalling |
US11807857B2 (en) | 2014-06-25 | 2023-11-07 | Monsanto Technology Llc | Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression |
WO2023242155A1 (en) | 2022-06-14 | 2023-12-21 | Janssen Vaccines & Prevention B.V. | Compositions and methods for the diagnosis of hiv infection |
US11957734B2 (en) | 2021-03-25 | 2024-04-16 | Baylor Research Institute | Methods and compositions for treating autoimmune and inflammatory conditions |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE388694B (en) * | 1975-01-27 | 1976-10-11 | Kabi Ab | WAY TO PROVIDE AN ANTIGEN EXV IN SAMPLES OF BODY WHEATS, USING POROST BERAR MATERIAL BONDED OR ADSORBING ANTIBODIES |
IN142734B (en) * | 1975-04-28 | 1977-08-20 | Miles Lab | |
GB1549069A (en) * | 1976-12-10 | 1979-08-01 | Erba Farmitalia | Enzyme linked immunoassay |
IT1153999B (en) * | 1977-03-15 | 1987-01-21 | Snam Progetti | COMPOSITION SUITABLE FOR DETERMINING TRIIODOTHYRONIN AND DIAGNOSTIC METHOD USING THE SAME |
CA1108516A (en) * | 1977-11-21 | 1981-09-08 | Stanley E. Charm | Antibiotic detection method |
NZ190452A (en) * | 1978-05-19 | 1981-04-24 | Becton Dickinson Co | Solid phase assay receptor contacted with analyte and then with labeled analyte |
JPS54170918U (en) * | 1978-05-23 | 1979-12-03 | ||
US4273756A (en) * | 1978-07-28 | 1981-06-16 | Abbott Laboratories | Immunoassay for class specific antibodies |
US4292296A (en) * | 1978-09-12 | 1981-09-29 | Baxter Travenol Laboratories, Inc. | Diagnostic method |
GB2059421A (en) * | 1979-10-03 | 1981-04-23 | Self C H | Assay method and reagents therefor |
US4446231A (en) * | 1979-10-03 | 1984-05-01 | Self Colin H | Immunoassay using an amplified cyclic detection system |
JPS56143955A (en) * | 1980-04-10 | 1981-11-10 | Fujirebio Inc | Method for diagnosis of initial infection of syphilis |
DE3016575A1 (en) * | 1980-04-30 | 1981-11-05 | Merck Patent Gmbh, 6100 Darmstadt | METHOD FOR THE IMMUNOLOGICAL DETERMINATION OF ENZYMES, MEANS FOR CARRYING OUT THE METHOD AND ITS RELATIONSHIP |
NZ199286A (en) * | 1980-12-22 | 1986-05-09 | Commw Serum Lab Commission | A method of detecting antibodies or an antigenic or haptenic substance in a sample |
JPS57193643U (en) * | 1981-06-03 | 1982-12-08 | ||
US4447528A (en) * | 1981-08-10 | 1984-05-08 | Corning Glass Works | Detecting intrinsic factor blocking site antibody |
US4837395A (en) * | 1985-05-10 | 1989-06-06 | Syntex (U.S.A.) Inc. | Single step heterogeneous assay |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654090A (en) * | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE341239B (en) * | 1967-09-06 | 1971-12-20 | Pharmacia Ab |
-
1971
- 1971-02-10 NL NL717101728A patent/NL154600B/en not_active IP Right Cessation
-
1972
- 1972-01-27 US US00221447A patent/US3791932A/en not_active Expired - Lifetime
- 1972-01-27 ZA ZA720548A patent/ZA72548B/en unknown
- 1972-02-01 GB GB469672A patent/GB1363565A/en not_active Expired
- 1972-02-02 AU AU38552/72A patent/AU468151B2/en not_active Expired
- 1972-02-04 CH CH165572A patent/CH573115A5/xx not_active IP Right Cessation
- 1972-02-07 CA CA134,026A patent/CA958314A/en not_active Expired
- 1972-02-08 FI FI341/72A patent/FI53894C/en active
- 1972-02-08 FR FR7204056A patent/FR2126760A5/fr not_active Expired
- 1972-02-09 SE SE7201498A patent/SE451098B/en unknown
- 1972-02-09 JP JP47014295A patent/JPS5247011B1/ja active Pending
- 1972-02-09 ES ES399608A patent/ES399608A1/en not_active Expired
- 1972-02-09 DK DK058072A patent/DK150170C/en not_active IP Right Cessation
- 1972-02-09 BR BR729/72A patent/BR7200729D0/en unknown
- 1972-02-09 DE DE2206103A patent/DE2206103B2/en not_active Ceased
- 1972-02-10 BE BE779209A patent/BE779209A/en not_active IP Right Cessation
-
1978
- 1978-05-11 CA CA303,100A patent/CA1040082B/en not_active Expired
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654090A (en) * | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
US3654090B1 (en) * | 1968-09-24 | 1982-07-20 |
Cited By (1362)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE31006E (en) * | 1968-09-24 | 1982-08-03 | Akzona Incorporated | Process for the demonstration and determination of reaction components having specific binding affinity for each other |
US4203802A (en) * | 1971-05-14 | 1980-05-20 | Syva Company | Inhibitable enzyme amplification assay |
US3875011A (en) * | 1972-11-06 | 1975-04-01 | Syva Co | Enzyme immunoassays with glucose-6-phosphate dehydrogenase |
US3904367A (en) * | 1973-08-15 | 1975-09-09 | Gen Electric | Contrast enhancement for immunological film detection |
US4039652A (en) * | 1973-10-11 | 1977-08-02 | Miles Laboratories, Inc. | Column method of immunoassay employing an immobilized binding partner |
US3951748A (en) * | 1974-11-11 | 1976-04-20 | Medical Products, Inc. | Sensitized matrix for detection of disease |
US4343896A (en) * | 1975-02-01 | 1982-08-10 | Akzona Incorporated | Method and test pack for the demonstration and determination of an antigen or antibody |
US4016043A (en) * | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
USRE32696E (en) * | 1975-09-04 | 1988-06-14 | Akzona Incorporated | Enzymatic immunological method for determination of antigens and antibodies |
FR2325934A1 (en) * | 1975-09-29 | 1977-04-22 | Cordis Corp | METHOD OF DETECTION OF THE PRESENCE OF AN ANTIGEN ASSOCIATED WITH HEPATITIS |
US4642285A (en) * | 1975-09-29 | 1987-02-10 | Diamedix Corporation | Sandwich EIA for antigen |
US4474878A (en) * | 1975-09-29 | 1984-10-02 | Cordis Laboratories, Inc. | Sandwich EIA for antigen associated with hepatitis |
DE2643829A1 (en) * | 1975-09-29 | 1977-04-14 | Cordis Corp | PROCEDURE FOR DETERMINING THE PRESENCE OF ANTIGENT ASSOCIATED WITH HEPATITIS |
US4116776A (en) * | 1976-04-19 | 1978-09-26 | International Radioimmune Systems, Inc. | Diagnostic blood test and kit for detecting human chorionic gonadotropin |
US4248965A (en) * | 1976-10-07 | 1981-02-03 | Mochida Seiyaku Kabushiki Kaisha | Immunochemical process of measuring physiologically active substances |
FR2367286A1 (en) * | 1976-10-07 | 1978-05-05 | Mochida Pharm Co Ltd | NEW PROCESS AND REAGENTS FOR IMMUNOCHEMICAL DOSAGE OF PHYSIOLOGICALLY ACTIVE SUBSTANCES |
US4200508A (en) * | 1977-02-09 | 1980-04-29 | Hidematsu Hirai | Method and composition for detecting antigenic substances |
US4302534A (en) * | 1977-03-16 | 1981-11-24 | Israel Institute For Biological Research | Chemiluminescent enzyme immunoassay |
US4254223A (en) * | 1978-04-18 | 1981-03-03 | Akzona Incorporated | Apparatus for colorimetric determination |
US4240751A (en) * | 1978-11-09 | 1980-12-23 | Akzona Incorporated | Method and apparatus for specific binding substances |
US4318707A (en) * | 1978-11-24 | 1982-03-09 | Syva Company | Macromolecular fluorescent quencher particle in specific receptor assays |
US4374925A (en) * | 1978-11-24 | 1983-02-22 | Syva Company | Macromolecular environment control in specific receptor assays |
US4275149A (en) * | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4331444A (en) * | 1979-03-01 | 1982-05-25 | Fuji Photo Film Co., Ltd. | Competitive immunoassay using silver halide fogging agent |
US4337063A (en) * | 1979-03-01 | 1982-06-29 | Fuji Photo Film Co., Ltd. | Competitive immunoassay using spectral sensitizer label |
US4269938A (en) * | 1979-03-08 | 1981-05-26 | Eastman Kodak Company | Assay of peroxidatively active materials |
WO1980002747A1 (en) * | 1979-05-31 | 1980-12-11 | Rapidex Ltd | Ultrasensitive enzymatic radioimmunoassay method |
US4289748A (en) * | 1979-05-31 | 1981-09-15 | United States Of America | Ultrasensitive enzymatic radioimmunoassay method |
WO1981002792A1 (en) * | 1980-03-20 | 1981-10-01 | Res Triangle Inst | Detection of antibiotics in milk |
US4362531A (en) * | 1980-04-15 | 1982-12-07 | Technicon Instruments Corporation | Agglutination immunoassays carried out with agent to reduce non-specific interferences |
US6406920B1 (en) | 1980-06-20 | 2002-06-18 | Inverness Medical Switzerland Gmbh | Processes and apparatus for carrying out specific binding assays |
US5610077A (en) * | 1980-06-20 | 1997-03-11 | Unilever Patent Holdings B.V. | Processes and apparatus for carrying out specific binding assays |
US6391563B1 (en) | 1980-07-28 | 2002-05-21 | Akzo Nobel N.V. | Method for the determination of antigens with the aid of three or more monoclonal antibodies |
US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4486530A (en) * | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
US4323647A (en) * | 1980-10-15 | 1982-04-06 | University Of Miami | Steric hindrance enzyme immunoassay |
WO1982002601A1 (en) * | 1981-01-23 | 1982-08-05 | Hospital Supply Corp American | Solid phase system for ligand assay |
US4517288A (en) * | 1981-01-23 | 1985-05-14 | American Hospital Supply Corp. | Solid phase system for ligand assay |
EP0060700A1 (en) * | 1981-03-13 | 1982-09-22 | Immuno-Mycologics, Inc. | Assay method and device |
US4446238A (en) * | 1981-03-19 | 1984-05-01 | Janssen Pharmaceutica N.V. | Bright field light microscopic method of localizing tissue antigens |
US4592995A (en) * | 1981-03-30 | 1986-06-03 | Dainippon Pharmaceutical Co., Ltd. | Reagent for streptococcal anti-esterase assay |
US4604365A (en) * | 1981-06-02 | 1986-08-05 | Electro-Nucleonics, Inc. | Immunoprecipitation assay |
WO1983000877A1 (en) * | 1981-08-31 | 1983-03-17 | Icl Scient | Glucose oxidase immunohistochemical detection of antinuclear antibodies |
US4452886A (en) * | 1981-09-21 | 1984-06-05 | Henry Robert P | Novel photon absorbing or emitting polymers and their use as reagents in immunoassay systems |
US4446232A (en) * | 1981-10-13 | 1984-05-01 | Liotta Lance A | Enzyme immunoassay with two-zoned device having bound antigens |
US4753875A (en) * | 1981-11-02 | 1988-06-28 | Ryan James W | Method for assaying proteases with tagged proteinaceous inhibitors |
US4506009A (en) * | 1982-03-30 | 1985-03-19 | University Of California | Heterogeneous immunoassay method |
US4469787A (en) * | 1982-05-14 | 1984-09-04 | Mallinckrodt Inc. | Immunoassay involving soluble complex of second antibody and labeled binding protein |
US4503143A (en) * | 1982-08-20 | 1985-03-05 | Btc Diagnostics Limited Partnership | Enzyme immunoassay with two-part solution of tetramethylbenzidine as chromogen |
WO1986004421A1 (en) * | 1982-08-20 | 1986-07-31 | Hygeia Sciences Limited Partnership | Enzyme immunoassay with two-part solution of tetramethylbenzidine as chromogen |
US4530900A (en) * | 1982-09-13 | 1985-07-23 | Seragen Diagnostics Inc. | Soluble insoluble polymers in enzymeimmunoassay |
US5047330A (en) * | 1983-08-17 | 1991-09-10 | Commissariat A L'energie Atomique | Compound labelled by the acetyl cholinesterase of Electrophorus electricus, its preparation process and its use as a tracer or marker in enzymoimmunological determinations |
WO1985002260A1 (en) * | 1983-11-08 | 1985-05-23 | Quidel | Rapid plunger immunoassay method and apparatus |
US5534405A (en) * | 1984-03-08 | 1996-07-09 | The Scripps Research Institute | Antibodies, diagnostic systems and methods for assaying HBxAg |
WO1985003950A1 (en) * | 1984-03-08 | 1985-09-12 | Scripps Clinic And Research Foundation | A sv40 expression vector containing hbxag as an expression marker |
WO1985004397A1 (en) | 1984-03-23 | 1985-10-10 | Oncogen | Platelet related growth regulator |
US4665020A (en) * | 1984-05-30 | 1987-05-12 | United States Department Of Energy | Flow cytometer measurement of binding assays |
US4812395A (en) * | 1984-11-05 | 1989-03-14 | E. I. Du Pont De Nemours And Company | Method for detecting enzymatic activity using particle agglutination |
US4812396A (en) * | 1984-11-05 | 1989-03-14 | E. I. Du Pont De Nemours And Company | Method for detecting enzymatic activity using particle agglutination |
US4713347A (en) * | 1985-01-14 | 1987-12-15 | Sensor Diagnostics, Inc. | Measurement of ligand/anti-ligand interactions using bulk conductance |
US4824784A (en) * | 1985-04-08 | 1989-04-25 | Hygeia Sciences, Incorporated | Chromogenic solution for immunoassay |
US4931385A (en) * | 1985-06-24 | 1990-06-05 | Hygeia Sciences, Incorporated | Enzyme immunoassays and immunologic reagents |
US4868108A (en) * | 1985-12-12 | 1989-09-19 | Hygeia Sciences, Incorporated | Multiple-antibody detection of antigen |
US4808522A (en) * | 1986-04-24 | 1989-02-28 | Moskovsky Gosudarstvennx Universitet Imeni M. V. Lomonoso VA | Enzyme immunoassays using inorganic pyrophosphatase |
US5334513A (en) * | 1988-05-17 | 1994-08-02 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
US5451507A (en) * | 1988-05-17 | 1995-09-19 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
US5468647A (en) * | 1988-05-17 | 1995-11-21 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
US5624809A (en) * | 1988-05-17 | 1997-04-29 | Behringwerke Ag | Device for immunochromatographic analysis |
US5102788A (en) * | 1988-11-21 | 1992-04-07 | Hygeia Sciences, Inc. | Immunoassay including lyophilized reactant mixture |
US5328828A (en) * | 1988-12-23 | 1994-07-12 | Syntex (U.S.A.) Inc. | Compositions and methods for determining the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine |
US5614504A (en) * | 1990-08-01 | 1997-03-25 | The University Of South Florida | Method of making inosine monophosphate derivatives and immunopotentiating uses thereof |
US5726015A (en) * | 1991-05-15 | 1998-03-10 | Vanderbilt University | Method to determine metastatic potential of tumor cells |
US5348867A (en) * | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
US5874423A (en) * | 1992-09-10 | 1999-02-23 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Digitalis-like compounds |
US20080076904A1 (en) * | 1993-03-17 | 2008-03-27 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated |
US5726023A (en) * | 1993-03-17 | 1998-03-10 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated |
US7247703B2 (en) | 1993-03-17 | 2007-07-24 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated |
US5801005A (en) * | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
US20050191285A1 (en) * | 1993-03-17 | 2005-09-01 | University Of Washington | Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated |
US7655239B2 (en) | 1993-03-17 | 2010-02-02 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated |
US8524491B2 (en) | 1993-03-17 | 2013-09-03 | University Of Washington Through Its Center For Commercialization | Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated |
US6664370B2 (en) | 1993-03-17 | 2003-12-16 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated |
US5846538A (en) * | 1993-03-17 | 1998-12-08 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the her-2/neu oncogene is associated |
US7601697B2 (en) | 1993-03-17 | 2009-10-13 | University Of Washington | Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated |
US5869445A (en) * | 1993-03-17 | 1999-02-09 | University Of Washington | Methods for eliciting or enhancing reactivity to HER-2/neu protein |
US6953573B1 (en) | 1993-03-17 | 2005-10-11 | University Of Washington | Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated |
US5876712A (en) * | 1993-03-17 | 1999-03-02 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated |
US20040082758A1 (en) * | 1993-03-17 | 2004-04-29 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated |
US6075122A (en) * | 1993-03-17 | 2000-06-13 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated |
US5672475A (en) * | 1993-05-06 | 1997-09-30 | Chiron Diagnostics Corporation | Mixed luminescent conjugate test |
US5837535A (en) * | 1994-06-13 | 1998-11-17 | Henry Ford Health System | Neuronal-neonatal gene: neuronatin |
US5916752A (en) * | 1994-10-20 | 1999-06-29 | Arch Development Corporation | Telomerase screening methods |
US5698686A (en) * | 1994-10-20 | 1997-12-16 | Arch Development Corporation | Yeast telomerase compositions |
US6387619B1 (en) | 1994-10-20 | 2002-05-14 | Arch Development | Telomerase compositions and methods |
US5843673A (en) * | 1994-10-25 | 1998-12-01 | Curators Of The University Of Missouri | Method of screening for endometriosis |
US6531277B2 (en) | 1994-10-25 | 2003-03-11 | The Curators Of The University Of Missouri | Endometriosis-specific secretory protein |
US20030152909A1 (en) * | 1994-11-16 | 2003-08-14 | Mitrani Eduardo N. | In vitro micro-organs, and uses related thereto |
US5728807A (en) * | 1995-05-16 | 1998-03-17 | Ramot-University Authority For Applied Research And Industrial Development, Ltd. | Mutated proteins associated with ataxia-telangiectasia |
US5777093A (en) * | 1995-05-16 | 1998-07-07 | Ramot-University Authority For Applied Research & Industrial Development Ltd. | cDNAs associated with ataxia-telangiectasia |
US6200749B1 (en) | 1995-05-16 | 2001-03-13 | Ramot-University Authority For Applied Research And Industrial Development Ltd. | Mutated forms of the ataxia-telangiectasia gene and method to screen for a partial A-T phenotype |
US5858661A (en) * | 1995-05-16 | 1999-01-12 | Ramot-University Authority For Applied Research And Industrial Development | Ataxia-telangiectasia gene and its genomic organization |
WO1997005886A1 (en) * | 1995-08-04 | 1997-02-20 | Board Of Regents, The University Of Texas System | Compositions for conferring immunogenicity to a peptide |
US5807552A (en) * | 1995-08-04 | 1998-09-15 | Board Of Regents, The University Of Texas System | Compositions for conferring immunogenicity to a substance and uses thereof |
US6689757B1 (en) | 1996-02-12 | 2004-02-10 | M.L. Laboratories Plc | Methods for vaccination and vaccines therefor |
US20060008479A1 (en) * | 1996-04-01 | 2006-01-12 | University Of Washington | Methods and compositions to generate immunity in humans against self tumor antigens by immunization with homologous foreign proteins |
US6312901B2 (en) | 1996-07-08 | 2001-11-06 | Burstein Technologies, Inc. | Spatially addressable, cleavable reflective signal elements, assay device and method |
US6342349B1 (en) | 1996-07-08 | 2002-01-29 | Burstein Technologies, Inc. | Optical disk-based assay devices and methods |
US20050069923A1 (en) * | 1996-07-08 | 2005-03-31 | Mullis Kary Banks | Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus |
US6331275B1 (en) | 1996-07-08 | 2001-12-18 | Burstein Technologies, Inc. | Spatially addressable, cleavable reflective signal elements, assay device and method |
US20050214827A1 (en) * | 1996-07-08 | 2005-09-29 | Burstein Technologies, Inc. | Assay device and method |
US20020106661A1 (en) * | 1996-07-08 | 2002-08-08 | Burstein Laboratories, Inc. | Optical disk-based assay devices and methods |
US5840322A (en) * | 1996-12-19 | 1998-11-24 | Ramot-University Authority For Applied Research & Industrial Devel. Ltd. | Anti-oral-microbial adhesion fraction derived from vaccinium |
US20030124116A1 (en) * | 1997-08-21 | 2003-07-03 | Quark Biotech, Inc. | Hypoxia-regulated genes |
US6740738B2 (en) | 1997-08-21 | 2004-05-25 | Quark Biotech, Inc. | Antibody against hypoxia proteins |
US6610838B1 (en) | 1997-09-10 | 2003-08-26 | Symbicom Aktiebolag | P13 antigens from Borrelia |
US6284496B1 (en) | 1997-10-03 | 2001-09-04 | University Of South Florida | DNA vector for determining the presence of out-of-reading-frame mutations |
US6482389B1 (en) | 1997-10-17 | 2002-11-19 | University Of South Florida | Method to diagnose and monitor cellular immune deficiencies |
US7687057B2 (en) | 1998-01-09 | 2010-03-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs, and uses related thereto |
US20090004158A1 (en) * | 1998-02-17 | 2009-01-01 | Tony Peled | Methods of controlling proliferation and differentiation of stem and progenitor cells |
US7855075B2 (en) | 1998-02-17 | 2010-12-21 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
US20110045589A1 (en) * | 1998-02-17 | 2011-02-24 | Gamida Cell Ltd. | Methods Of Controlling Proliferation And Differentiation Of Stem And Progenitor Cells |
US8202724B2 (en) | 1998-02-17 | 2012-06-19 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
US6344443B1 (en) | 1998-07-08 | 2002-02-05 | University Of South Florida | Peptide antagonists of tumor necrosis factor alpha |
US7605149B1 (en) | 1998-07-13 | 2009-10-20 | University Of South Florida | Modulation of the phospholipase A2 pathway as a therapeutic |
US7347972B1 (en) | 1998-07-22 | 2008-03-25 | Jin Po Lee | Multiple analyte assay device |
US6187563B1 (en) | 1998-08-07 | 2001-02-13 | Yale University | βIV-spectrin-polypeptides and nucleic acids encoding same |
US6656471B1 (en) | 1998-11-17 | 2003-12-02 | Board Of Regents, The University Of Texas System | HIV-specific T-cell induction |
US20050032039A1 (en) * | 1998-11-17 | 2005-02-10 | Sastry K. Jagannadha | HIV-specific T-cell induction |
US7306804B2 (en) | 1998-11-17 | 2007-12-11 | Board Of Regents, The University Of Texas System | HIV-specific T-cell induction |
EP2311938A1 (en) | 1999-02-04 | 2011-04-20 | Pluristem Ltd. | Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells |
EP2208782A2 (en) | 1999-02-04 | 2010-07-21 | Pluristem Ltd. | Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells |
US7678573B2 (en) | 1999-02-04 | 2010-03-16 | Pluristem Ltd. | Method of preparing a conditioned medium from a confluent stromal cell culture |
US20050180958A1 (en) * | 1999-02-04 | 2005-08-18 | Technion Research & Development Foundation Ltd. | Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells |
US20050176137A1 (en) * | 1999-02-04 | 2005-08-11 | Technion Research & Development Foundation Ltd. | Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells |
US20050181504A1 (en) * | 1999-02-04 | 2005-08-18 | Technion Research & Development | Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells |
US20050176143A1 (en) * | 1999-02-04 | 2005-08-11 | Technion Research & Development | Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells |
US7534609B2 (en) | 1999-02-04 | 2009-05-19 | Pluristem Life Systems Inc. | Method of expanding undifferentiated hemopoietic stem cells |
US6440682B1 (en) * | 1999-05-28 | 2002-08-27 | Detroit R&D Inc. | Detection of hypertension using immunoreactive metabolic products |
US6787318B1 (en) | 1999-06-01 | 2004-09-07 | Roskamp Research Institute, Llc | Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology |
US20050089939A1 (en) * | 1999-06-01 | 2005-04-28 | Jun Tan | Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology |
US20060019340A1 (en) * | 1999-06-08 | 2006-01-26 | David Naor | CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases |
US8193311B2 (en) | 1999-06-08 | 2012-06-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases |
US7534605B2 (en) | 1999-06-08 | 2009-05-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases |
US20060127366A1 (en) * | 1999-06-25 | 2006-06-15 | Mitrani Eduardo N | Method and device for inducing biological processes by micro-organs |
US20030086914A1 (en) * | 1999-06-25 | 2003-05-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method and device for inducing biological processes by micro-organs |
US6875582B1 (en) | 1999-08-19 | 2005-04-05 | Omniscience Pharmaceuticals, Inc. | Methods and targets of antibiotic resistance |
US20110008314A1 (en) * | 1999-08-30 | 2011-01-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of and compositions for inhibiting the proliferation of mammalian cells |
US7101839B1 (en) | 1999-08-30 | 2006-09-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of and compositions for inhibiting the proliferation of mammalian cells |
US8735127B2 (en) | 1999-08-30 | 2014-05-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of and compositions for inhibiting the proliferation of mammalian cells |
US20050113327A1 (en) * | 1999-08-30 | 2005-05-26 | Levava Roiz | Methods of and compositions for inhibiting the proliferation of mammalian cells |
US8617867B2 (en) | 1999-08-30 | 2013-12-31 | Yissum Research Develpment Company Of The Hebrew University Of Jerusalem | Methods of and compositions for inhibiting the proliferation of mammalian cells |
US8236543B2 (en) | 1999-08-30 | 2012-08-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of and compositions for inhibiting the proliferation of mammalian cells |
US7811981B2 (en) | 1999-08-30 | 2010-10-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of and compositions for inhibiting the proliferation of mammalian cells |
US6998232B1 (en) | 1999-09-27 | 2006-02-14 | Quark Biotech, Inc. | Methods of diagnosing bladder cancer |
US10359573B2 (en) | 1999-11-05 | 2019-07-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-granting devices and methods for using same |
US20070292930A1 (en) * | 1999-11-19 | 2007-12-20 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of producing recombinant Aspergillus niger beta-glucosidase and an aroma spreading plant |
US7223902B1 (en) | 1999-11-19 | 2007-05-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of producing recombinant Aspergillus niger β-glucosidase and an aroma spreading plant |
US7270810B2 (en) | 2000-01-05 | 2007-09-18 | Yeda Research And Development Co. Ltd. | Veto cells effective in preventing graft rejection and devoid of graft versus host potential |
US20070264274A1 (en) * | 2000-01-05 | 2007-11-15 | Yeda Research And Development Co. Ltd. | Veto cells effective in preventing graft rejection and devoid of graft versus host potential |
US20030211490A1 (en) * | 2000-01-24 | 2003-11-13 | Hanan Stein | Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby |
US7385106B2 (en) | 2000-01-24 | 2008-06-10 | Ramot At Tel Aviv University Ltd. | Plants tolerant of environmental stress conditions, methods of generating same and novel polynucleotide sequence utilized thereby |
US9095533B2 (en) | 2000-03-27 | 2015-08-04 | Technion Research & Development Foundation Limited | Antigen-presenting complex-binding compositions and uses thereof |
EP2316950A1 (en) | 2000-03-27 | 2011-05-04 | Technion Research and Development Foundation, Ltd. | Single chain class I major histo-compatibility complexes, constructs encoding same and methods of generating same |
US20030104491A1 (en) * | 2000-04-30 | 2003-06-05 | Cabantchik Ioav Zvi | Molecules and methods using same for measuring non-transferrin bound iron |
US8088160B2 (en) | 2000-07-20 | 2012-01-03 | Multi-Gene Vascular Systems Ltd. (“MGVS”) | Drug-eluting intravascular prostheses and methods of use |
EP2359853A1 (en) | 2000-08-08 | 2011-08-24 | Technion Research and Development Foundation, Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis |
EP2359854A1 (en) | 2000-08-08 | 2011-08-24 | Technion Research and Development Foundation, Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis |
US20030114410A1 (en) * | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
EP1683874A2 (en) | 2000-08-29 | 2006-07-26 | YEDA RESEARCH AND DEVELOPMENT Co. LTD. | Methods of isolating genes encoding proteins of specific function and of screening for pharmaceutically active agents |
US20070281037A9 (en) * | 2000-09-28 | 2007-12-06 | Nanocyte Inc. | Sterile preparations and compositions including stinging capsules and methods of producing and using same |
US8062660B2 (en) | 2000-09-28 | 2011-11-22 | Nanocyte Inc. | Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue |
US7632522B2 (en) | 2000-09-28 | 2009-12-15 | Nanocyte Inc. | Use of stinging cells/capsules for the delivery of active agents to keratinous substances |
US20060099273A1 (en) * | 2000-09-28 | 2006-05-11 | Nanocyte Inc. | Sterile preparations and compositions including stinging capsules and methods of producing and using same |
US20070160546A1 (en) * | 2000-09-28 | 2007-07-12 | Tamar Lotan | Use of stinging cells/capsules for the delivery of active agents to keratinous substances |
US20060159769A1 (en) * | 2000-09-28 | 2006-07-20 | Nanocyte Inc. | Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue |
US20040076976A1 (en) * | 2000-11-02 | 2004-04-22 | Pan Shen Quan | Aopb gene, protein,homologs, fragments and variants thereof, and their use for cell surface display |
US7060462B2 (en) | 2000-11-02 | 2006-06-13 | National University Of Singapore | AopB gene, protein,homologs, fragments and variants thereof, and their use for cell surface display |
EP2186530A1 (en) | 2000-11-17 | 2010-05-19 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
EP2425841A1 (en) | 2000-11-24 | 2012-03-07 | Vascular Biogenics Ltd. | Methods Employing and Compositions Containing Defined Oxidized Phospholipids for Prevention and Treatment of Atherosclerosis |
US20020172980A1 (en) * | 2000-11-27 | 2002-11-21 | Phan Brigitte Chau | Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems |
US20040248093A1 (en) * | 2000-11-27 | 2004-12-09 | Coombs James Howard | Magneto-optical bio-discs and systems including related methods |
US20030003464A1 (en) * | 2000-11-27 | 2003-01-02 | Phan Brigitte C. | Dual bead assays including optical biodiscs and methods relating thereto |
US20040052769A1 (en) * | 2000-11-30 | 2004-03-18 | Yair Reisner | Methods of utilizing cultured non-gvhd inducing t lymphocytes to treat disease |
WO2002044736A2 (en) | 2000-11-30 | 2002-06-06 | Molecular Skincare Limited | Diagnosis and treatment of epidermal or skin diseases |
EP2357478A2 (en) | 2000-11-30 | 2011-08-17 | Crawford Healthcare Holdings Limited | Diagnosis of disease |
US20020142287A1 (en) * | 2000-12-14 | 2002-10-03 | Hirotaka Yamamoto | High throughput assay to detect inhibitors of the map kinase pathway |
US7087395B1 (en) | 2001-01-16 | 2006-08-08 | Quest Diagnostics Investments Incorporated | Vitamin D assay |
US20050202098A1 (en) * | 2001-01-31 | 2005-09-15 | Tolaren | Disease therapy using dying or dead cells |
US20050031618A1 (en) * | 2001-01-31 | 2005-02-10 | Dror Mevorach | Induction of tolerance by apoptotic and/or necrotic cells |
EP2308994A1 (en) | 2001-03-23 | 2011-04-13 | Yeda Research And Development Co., Ltd. | Methods for determining a risk to develop cancer |
US7033747B2 (en) | 2001-04-11 | 2006-04-25 | Nagaoka & Co., Ltd | Multi-parameter assays including analysis discs and methods relating thereto |
US6770622B2 (en) | 2001-06-08 | 2004-08-03 | Gary A. Jarvis | N-terminally truncated galectin-3 for use in treating cancer |
US20050022269A1 (en) * | 2001-07-19 | 2005-01-27 | Joseph Hirschberg | Polypeptides having carotenoids isomerase catalytic activity, nucleic acids encoding same and uses thereof |
US7442781B2 (en) | 2001-08-16 | 2008-10-28 | Urifer Ltd. | Diagnosis, prevention and treatment of cancer |
US7138144B2 (en) | 2001-09-07 | 2006-11-21 | Nadir Askenasy | Method of inducing immune tolerance via blood/lymph flow-restricted bone marrow transplantation |
US20030064058A1 (en) * | 2001-09-07 | 2003-04-03 | Nadir Askenasy | Methods of utilizing bone marrow stem cells for inducing immunological tolerance |
US8415318B2 (en) | 2001-10-19 | 2013-04-09 | Vascular Biogenics Ltd. | Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
US20100088037A1 (en) * | 2001-10-23 | 2010-04-08 | Epipop Pty Ltd. | Method for Identification and Development of Therapeutic Agents |
US20060257865A1 (en) * | 2001-10-23 | 2006-11-16 | Simon Mallal | Method for identification and development of therapeutic agents |
US6867005B2 (en) | 2001-10-24 | 2005-03-15 | Beckman Coulter, Inc. | Method and apparatus for increasing the dynamic range and accuracy of binding assays |
WO2003046201A2 (en) | 2001-11-21 | 2003-06-05 | Kimberly-Clark Worldwide, Inc. | Detection and identification of enteric bacteria |
US20060051426A1 (en) * | 2001-12-05 | 2006-03-09 | Gershon Golomb | Nanoparticles containing polymeric nucleic acid homologs pharmaceutical composition and articles of manufacture containing same and methods of use thereof |
US8178128B2 (en) | 2001-12-05 | 2012-05-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Nanoparticles containing polymeric nucleic acid homologs |
US20050085432A1 (en) * | 2001-12-26 | 2005-04-21 | Aviva Lapidot | Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections |
US20050008624A1 (en) * | 2002-01-24 | 2005-01-13 | Tony Peled | Expansion of renewable stem cell populations |
US20110033427A1 (en) * | 2002-01-24 | 2011-02-10 | Gamida Cell Ltd. | Expansion Of Renewable Stem Cell Populations |
EP2305794A1 (en) | 2002-01-24 | 2011-04-06 | Gamida Cell Ltd. | Expansion of renewable stem cell populations |
US7955852B2 (en) | 2002-01-24 | 2011-06-07 | Gamida Cell Ltd. | Expansion of renewable stem cell populations |
US20080279828A1 (en) * | 2002-01-25 | 2008-11-13 | Tony Peled | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
US7655225B2 (en) | 2002-01-25 | 2010-02-02 | Gamida Cell, Ltd. | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
US7781396B2 (en) | 2002-01-31 | 2010-08-24 | Tel Aviv University Future Technology Development L.P. | Peptides directed for diagnosis and treatment of amyloid-associated disease |
US8697634B2 (en) | 2002-01-31 | 2014-04-15 | Tel Aviv University Future Technology Development L.P. | Peptides and methods using same for diagnosis and treatment of amyloid-associated disease |
US8012929B2 (en) | 2002-01-31 | 2011-09-06 | Tel Aviv University Future Technology Development L.P. | Peptides directed for diagnosis and treatment of amyloid-associated diseases |
US20060234947A1 (en) * | 2002-01-31 | 2006-10-19 | Tel Aviv University Future Technology Development L.P | Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases |
US8993510B2 (en) | 2002-01-31 | 2015-03-31 | Tel Aviv University Future Technology Development L.P. | Peptides and methods using same for diagnosis and treatment of amyloid-associated disease |
US20100105608A1 (en) * | 2002-01-31 | 2010-04-29 | Tel Aviv University Future Technology Development L.P. | Peptides and methods using same for diagnosis and treatment of amyloid-associated disease |
US20100022459A1 (en) * | 2002-01-31 | 2010-01-28 | Tel Aviv University Future Technology Development L.P | Peptides directed for diagnosis and treatment of amyloid-associated diseases |
US6992176B2 (en) | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
EP2329814A1 (en) | 2002-02-13 | 2011-06-08 | Technion Research and Development Foundation, Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer |
US20050255101A1 (en) * | 2002-02-13 | 2005-11-17 | Technion Research And Development Foundation Ltd. | Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
EP2072045A2 (en) | 2002-02-13 | 2009-06-24 | Technion Research and Development Foundation, Ltd. | Antibody having a t-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
US20050287141A1 (en) * | 2002-02-13 | 2005-12-29 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
US7718777B2 (en) | 2002-02-20 | 2010-05-18 | Technion Research & Development Foundation Ltd. | MHC-peptide complex binding ligands |
US20070196369A1 (en) * | 2002-02-20 | 2007-08-23 | Hoogenboom Henricus Renerus J | MHC-peptide complex binding ligands |
US20100228007A1 (en) * | 2002-02-20 | 2010-09-09 | Technion Research & Development Foundation Ltd. | Mhc-peptide complex binding ligands |
EP2508596A2 (en) | 2002-02-21 | 2012-10-10 | Bayer Healthcare | MN/CA IX-specific monoclonal antibodies generated from MN/CA IX-deficient mice and methods of use |
EP3031910A1 (en) | 2002-02-21 | 2016-06-15 | Institute Of Virology | Mn/ca ix-specific monoclonal antibodies generated from mn/ca ix-deficient mice and methods of use |
US20050220774A1 (en) * | 2002-03-18 | 2005-10-06 | Tony Peled | Methods of inducing differentiation in ex vivo expanded stem cells |
US20060039897A1 (en) * | 2002-03-26 | 2006-02-23 | Tamar Lotan | Stinging cells expressing an exogenous polycleotide encoding a therpeutic, diagnostics or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derive therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue |
US7611723B2 (en) | 2002-03-26 | 2009-11-03 | Nanocyte Inc. | Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostic or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derived therefrom for delivering the therapeutic, diagnostic or cosmetic agent into a tissue |
US20050158809A1 (en) * | 2002-04-16 | 2005-07-21 | The Regents Of The University Of Califorina | Methods of renal cell carcinoma prognosis and treatment selection with carbonic anhydrase IX |
US8936914B2 (en) | 2002-04-16 | 2015-01-20 | The Regents Of The University Of California | Methods of renal cell carcinoma prognosis and treatment selection with carbonic anhydrase IX |
US20040121442A1 (en) * | 2002-05-05 | 2004-06-24 | Ilan Chet | Fungal chitinase, polynucleotide sequences encoding same, promoters of same, and uses thereof |
EP2561889A2 (en) | 2002-08-01 | 2013-02-27 | Yeda Research and Development Co. Ltd. | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels |
WO2004018698A2 (en) | 2002-08-20 | 2004-03-04 | Genitrix, Llc | Lectin compositions and methods for modulating an immune response to an antigen |
US8563273B2 (en) | 2002-09-06 | 2013-10-22 | Tel Aviv University Future Technology Development L.P. | Method of screening for compounds that disaggregate amyloid aggregates |
US20090209041A1 (en) * | 2002-09-06 | 2009-08-20 | Tel Aviv University Future Technology Development L.P. | Peptides and methods for inhibiting amyloid formation |
EP2182052A1 (en) | 2002-10-07 | 2010-05-05 | Technion Research and Development Foundation, Ltd. | Human foreskin cells suitable for culturing stem cells |
US20040146949A1 (en) * | 2002-10-25 | 2004-07-29 | Jun Tan | Methods and compounds for disruption of CD40R/CD40L signaling in the treatment of alzheimer's disease |
EP2295980A1 (en) | 2002-10-30 | 2011-03-16 | Yissum Research Development Company, of The Hebrew University of Jerusalem | Molecules and methods using same for measuring non-transferrin bound iron |
US20050054097A1 (en) * | 2002-11-17 | 2005-03-10 | Tony Peled | EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures |
US8168180B2 (en) | 2002-11-27 | 2012-05-01 | Technion Research & Development Foundation Ltd. | Methods and compositions for modulating angiogenesis |
EP2062919A2 (en) | 2002-11-27 | 2009-05-27 | Technion Research and Development Foundation, Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors |
US8815823B2 (en) | 2002-11-27 | 2014-08-26 | Technion Research & Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors |
US20060127402A1 (en) * | 2002-11-27 | 2006-06-15 | Technion Research & Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors |
US20100119515A1 (en) * | 2002-11-27 | 2010-05-13 | Gera Neufeld | Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors |
US8163494B2 (en) | 2002-11-27 | 2012-04-24 | Technion Research & Development Foundation Ltd. | Method for assessing metastatic properties of breast cancer |
EP2062918A2 (en) | 2002-11-27 | 2009-05-27 | Technion Research and Development Foundation, Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis, inhibiting metastasis and tumor fibrosis, and assessing the malignancy of colon cancer tumors |
US20110027887A1 (en) * | 2002-11-29 | 2011-02-03 | Technion Research & Development Foundation Ltd. | Method of dynamically culturing embryonic stem cells |
US7947499B2 (en) | 2002-11-29 | 2011-05-24 | Technion Research & Development Foundation Ltd. | Method of dynamically culturing embryonic stem cells |
US20060148078A1 (en) * | 2002-11-29 | 2006-07-06 | Sharon Gerecht-Nir | Method of dynamically culturing embryonic stem cells |
US20090123553A1 (en) * | 2002-12-09 | 2009-05-14 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures and methods of generating and using the same |
US8053554B2 (en) | 2002-12-09 | 2011-11-08 | Ramot At Tel-Aviv University Ltd. | Peptide nanostructures and methods of generating and using the same |
EP2338896A2 (en) | 2002-12-12 | 2011-06-29 | R.B.T. (Rakuto Bio Technologies) Ltd. | Use of lignin peroxidase in skin and hair lightening |
EP2457999A2 (en) | 2002-12-16 | 2012-05-30 | Technion Research & Development Foundation Ltd. | Culture medium for pluropotent stem cells |
EP2292762A2 (en) | 2002-12-20 | 2011-03-09 | Board of Regents, The University of Texas System | VMP-like sequences of pathogenic Borrelia species and strains |
WO2004060135A2 (en) | 2003-01-02 | 2004-07-22 | Rappaport Family Institute For Research In The Medical Sciences | Methods of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients |
US8017586B2 (en) | 2003-01-07 | 2011-09-13 | Ramot At Tel-Aviv University Ltd. | Peptide nanostructures encapsulating a foreign material and method of manufacturing same |
US20090121709A1 (en) * | 2003-01-07 | 2009-05-14 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures encapsulating A foreign material and method of manufacturing same |
EP2058275A1 (en) | 2003-01-07 | 2009-05-13 | Ramot at Tel-Aviv University Ltd. | Peptide nanostructures encapsulating a foreign material and method of manufacturing same |
US20050032126A1 (en) * | 2003-03-03 | 2005-02-10 | Coombs James H. | Methods and apparatus for use in detection and quantitation of various cell types and use of optical bio-disc for performing same |
EP2319857A2 (en) | 2003-03-04 | 2011-05-11 | Yeda Research And Development Co., Ltd. | Pon polypeptides, polynucleotides encoding same and compositions and methods utilizing same |
EP2216033A2 (en) | 2003-03-06 | 2010-08-11 | Yeda Research and Development Co. Ltd. | Methods of treating disease by transplantation of allogeneic or xenogeneic organs or tissues |
US20050054103A1 (en) * | 2003-03-07 | 2005-03-10 | Tony Peled | Expansion of renewable stem cell populations using modulators of PI 3-kinase |
US7632923B2 (en) | 2003-03-26 | 2009-12-15 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US9023348B2 (en) | 2003-03-26 | 2015-05-05 | Technion Research & Development Foundation Limited | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US7638124B2 (en) | 2003-03-26 | 2009-12-29 | Technion Research & Development Foundation Ltd. | Antigen-presenting complex-binding compositions and uses thereof |
US20100080805A1 (en) * | 2003-03-26 | 2010-04-01 | Technion Research & Development | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US9616112B2 (en) | 2003-03-26 | 2017-04-11 | Technion Research & Development Foundation Limited | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US20060083735A1 (en) * | 2003-03-26 | 2006-04-20 | Technion Research & Development Foundation Ltd. | Antigen-presenting complex-binding compositions and uses thereof |
US20050152912A1 (en) * | 2003-03-26 | 2005-07-14 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
US20040197334A1 (en) * | 2003-04-02 | 2004-10-07 | Technion Research & Development Foundation Ltd. | Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same |
US7294701B2 (en) | 2003-04-02 | 2007-11-13 | Technion Research & Development Foundation Ltd. | Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same |
EP2330132A1 (en) | 2003-04-04 | 2011-06-08 | Yeda Research and Development Co. Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
US8252588B2 (en) | 2003-04-08 | 2012-08-28 | Yeda Research And Development Co. Ltd. | Stem cells having increased sensitivity to SDF-1 and methods of generating and using same |
US9463241B2 (en) | 2003-04-09 | 2016-10-11 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Method for stabilising an immunoglobulin G composition in liquid form |
US8388954B2 (en) | 2003-04-09 | 2013-03-05 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Stabilising formulation for immunoglobulin G compositions in liquid form and in lyophilised form |
US7355079B2 (en) | 2003-04-18 | 2008-04-08 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
US20060035980A1 (en) * | 2003-04-18 | 2006-02-16 | Scanlan Thomas S | Thyronamine derivatives and analogs and methods of use thereof |
US20050002953A1 (en) * | 2003-05-06 | 2005-01-06 | Jens Herold | SARS-coronavirus virus-like particles and methods of use |
US7554007B2 (en) | 2003-05-22 | 2009-06-30 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants |
EP2365087A2 (en) | 2003-05-22 | 2011-09-14 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
US10184132B2 (en) | 2003-05-22 | 2019-01-22 | Evogene Ltd. | Methods of increasing abiotic stress tolerance, yield and/or biomass in plants |
US20060123516A1 (en) * | 2003-05-22 | 2006-06-08 | Gil Ronen | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
US9303269B2 (en) | 2003-05-22 | 2016-04-05 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants |
US8481812B2 (en) | 2003-05-22 | 2013-07-09 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants generated thereby |
US20090260109A1 (en) * | 2003-05-22 | 2009-10-15 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants genterated thereby |
US9567579B2 (en) | 2003-05-23 | 2017-02-14 | Board Of Regents, The University Of Texas System | Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting AP-1 transcription factors |
US20050020499A1 (en) * | 2003-05-27 | 2005-01-27 | Bar Ilan University | Methods of attenuating cocaine seeking behavior employing glial cell-derived neurotrophic factor (GDNF) and pharmaceutical compositions and articles of manufacture suited for use in practice of the method |
US7498428B2 (en) | 2003-06-19 | 2009-03-03 | Evogene Ltd. | Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same |
US20090253170A1 (en) * | 2003-06-19 | 2009-10-08 | Evogene Ltd. | Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same |
US20060260002A1 (en) * | 2003-06-19 | 2006-11-16 | Gil Ronen | Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same |
US8129514B2 (en) | 2003-06-19 | 2012-03-06 | Evogene Ltd. | Nucleotide sequences for regulating gene expression in plant trichomes and constructs and methods utilizing same |
EP2719394A1 (en) | 2003-06-30 | 2014-04-16 | Tel Aviv University Future Technology Development L.P. | Peptides antibodies directed thereagainst for diagnosing and treating amyloid-associated diseases |
US20110229495A1 (en) * | 2003-07-07 | 2011-09-22 | Wagner David H | Methods for predicting development of auto-immune diseases and treatment of same |
EP2526953A1 (en) | 2003-07-15 | 2012-11-28 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
EP2540302A1 (en) | 2003-07-15 | 2013-01-02 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
EP2540301A2 (en) | 2003-07-15 | 2013-01-02 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
EP2526952A1 (en) | 2003-07-15 | 2012-11-28 | Bar-Ilan University | Methods and pharmaceutical compositions for healing wounds |
US20050271643A1 (en) * | 2003-08-14 | 2005-12-08 | Iryna Sorokulova | Bacterial strains, compositions including same and probiotic use thereof |
US7625707B2 (en) | 2003-10-02 | 2009-12-01 | Ramot At Tel Aviv University Ltd. | Antibacterial agents and methods of identifying and utilizing same |
EP2354164A1 (en) | 2003-10-07 | 2011-08-10 | Yeda Research And Development Co., Ltd. | Anti-NIK antibodies and uses thereof |
EP2322561A1 (en) | 2003-10-07 | 2011-05-18 | Yeda Research And Development Co., Ltd. | Anti-NIK antibodies and uses thereof |
WO2005033145A1 (en) | 2003-10-07 | 2005-04-14 | Yeda Research And Development Co. Ltd. | Antibodies to nik, their preparation and use |
WO2005033142A2 (en) | 2003-10-07 | 2005-04-14 | Yeda Research And Development Co. Ltd. | Anti-nik antibodies and uses thereof |
US20060257429A1 (en) * | 2003-10-23 | 2006-11-16 | Dreier Kimberly J | Vaccine for periodontal disease |
EP2301575A1 (en) | 2003-11-04 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for solid tumors expressing the CD40 cell-surface antigen |
EP2243492A1 (en) | 2003-11-04 | 2010-10-27 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma |
EP2248830A1 (en) | 2003-11-04 | 2010-11-10 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-CD40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection |
EP2149585A1 (en) | 2003-11-04 | 2010-02-03 | Novartis Vaccines and Diagnostics, Inc. | Antagonist anti-CD40 monoclonal antibodies and methods for their use |
EP2243491A1 (en) | 2003-11-04 | 2010-10-27 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-CD40 monoclonal antibodies for treatment of chronic lymphocytic leukemia |
WO2005051423A2 (en) | 2003-11-30 | 2005-06-09 | Yeda Research And Development Co. Ltd | Methods and agents for immune modulation and methods for identifying immune modulators |
US7790673B2 (en) | 2003-12-12 | 2010-09-07 | New York University | Methods and compositions relating to cystatin C |
US20070032421A1 (en) * | 2003-12-12 | 2007-02-08 | Efrat Levy | Methods and compositions relating to cystatin C |
US20100221233A1 (en) * | 2003-12-15 | 2010-09-02 | University Of South Florida | Compositions and methods for enhancing neuroprotection via administration of stem cells and blood brain barrier permeabilizers |
EP2289567A2 (en) | 2003-12-22 | 2011-03-02 | Regentis Biomaterials Ltd. | Matrix comprising naturally-occurring crosslinked protein backbone |
US8007847B2 (en) | 2004-01-13 | 2011-08-30 | Eytan Biderman | Feeding formula appliance |
US20060278093A1 (en) * | 2004-01-13 | 2006-12-14 | Eytan Biderman | Feeding formula appliance |
US20080312179A1 (en) * | 2004-01-20 | 2008-12-18 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5'-UTR |
US20050158822A1 (en) * | 2004-01-20 | 2005-07-21 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5'-UTR |
US7893240B2 (en) | 2004-01-20 | 2011-02-22 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5′-UTR |
US7423139B2 (en) | 2004-01-20 | 2008-09-09 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5′-UTR |
US20110091454A1 (en) * | 2004-01-27 | 2011-04-21 | Alex Diber | Methods and systems for annotating biomolecular sequences |
EP3006039A1 (en) | 2004-03-02 | 2016-04-13 | Acceleron Pharma Inc. | Alk7 polypeptides for use in promoting fat loss |
US8352031B2 (en) | 2004-03-10 | 2013-01-08 | Impulse Dynamics Nv | Protein activity modification |
EP2336330A2 (en) | 2004-06-14 | 2011-06-22 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
US20090126042A1 (en) * | 2004-06-14 | 2009-05-14 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
US8962915B2 (en) | 2004-06-14 | 2015-02-24 | Evogene Ltd. | Isolated polypeptides, polynucleotides encoding same, transgenic plants expressing same and methods of using same |
US9012728B2 (en) | 2004-06-14 | 2015-04-21 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
US20100281571A1 (en) * | 2004-06-14 | 2010-11-04 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
EP2343373A1 (en) | 2004-06-14 | 2011-07-13 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
US20080004234A1 (en) * | 2004-07-06 | 2008-01-03 | Segev Laboratories Limited | System for delivering therapeutic agents into living cells and cells nuclei |
US8680062B2 (en) | 2004-07-06 | 2014-03-25 | Deliversir Ltd. | System for delivering therapeutic agents into living cells and cells nuclei |
US20090156471A1 (en) * | 2004-07-15 | 2009-06-18 | Ramot At Tel Aviv University Ltd. | Use of anti-amyloid agents for treating and typing pathogen infections |
US20110151436A1 (en) * | 2004-09-08 | 2011-06-23 | The Government of the United States of America as represented by the Secretary, Dept. of Health | Compositions and methods for the detection of hiv-1/hiv-2 infection |
EP2295973A1 (en) | 2004-09-08 | 2011-03-16 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Compositions and methods for the detection of HIV-1/HIV-2 infection. |
US9121855B2 (en) | 2004-09-08 | 2015-09-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for the detection of HIV-1 antibodies utilizing a peptide containing a novel gp41 epitope |
EP2295974A1 (en) | 2004-09-08 | 2011-03-16 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Compositions and methods for the detection of HIV-1/HIV-2 infection |
US7888003B2 (en) | 2004-09-08 | 2011-02-15 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for the detection of HIV-1 antibodies employing polypeptides obtained from gag P6 protein |
EP2309269A1 (en) | 2004-09-08 | 2011-04-13 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Compositions and methods for the detection of HIV-1/HIV-2 infection. |
US20110201035A1 (en) * | 2004-09-08 | 2011-08-18 | The United States Of America As Represented By The Secretary Of Health And Human Services, Nih | Compositions and methods for the detection of hiv-1/hiv-2 infection |
US8722324B2 (en) | 2004-09-08 | 2014-05-13 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Methods for the detection of HIV-1-specific antibodies employing GP41 polypeptides |
US20070077652A1 (en) * | 2004-09-16 | 2007-04-05 | Tony Peled | Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells |
US8080417B2 (en) | 2004-09-16 | 2011-12-20 | Gamida-Cell Ltd. | Methods of ex vivo hematopoietic stem cell expansion by co-culture with mesenchymal cells |
US8000900B2 (en) | 2004-09-21 | 2011-08-16 | Microsoft Corporation | Association-based predictions of pathogen characteristics |
US20080131419A1 (en) * | 2004-09-29 | 2008-06-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Recombinant Human T2 Rnase and Uses Thereof |
US8039240B2 (en) | 2004-09-29 | 2011-10-18 | Yissum Reseach Development Company Of The Hebrew University Of Jerusalem | Recombinant human T2 RNase and uses thereof |
EP3088528A1 (en) | 2004-09-29 | 2016-11-02 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
EP2816117A2 (en) | 2004-09-29 | 2014-12-24 | Collplant Ltd. | Collagen producing plants and methods of generating and using same |
US7781402B2 (en) | 2004-10-12 | 2010-08-24 | Closed Loop Therapies Ltd. | Methods and implantable devices for treating supraventricular arrhythmias |
US20110040248A1 (en) * | 2004-10-12 | 2011-02-17 | Closed Loop Therapies Bv | Methods and implantable devices for treating supraventricular arrhythmias |
US20060079941A1 (en) * | 2004-10-12 | 2006-04-13 | Eli Ovsyshcher | Methods and implantable devices for treating supraventricular arrhythmias |
US20060190226A1 (en) * | 2004-10-29 | 2006-08-24 | Microsoft Corporation | Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails |
US20060095241A1 (en) * | 2004-10-29 | 2006-05-04 | Microsoft Corporation | Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails |
US8478535B2 (en) | 2004-10-29 | 2013-07-02 | Microsoft Corporation | Systems and methods that utilize machine learning algorithms to facilitate assembly of aids vaccine cocktails |
US20090118132A1 (en) * | 2004-11-04 | 2009-05-07 | Roche Molecular Systems, Inc. | Classification of Acute Myeloid Leukemia |
EP2174668A2 (en) | 2004-11-14 | 2010-04-14 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US20060134680A1 (en) * | 2004-12-22 | 2006-06-22 | Alexander Kotlyar | Homogeneous populations of nucleic acids, methods of synthesyzing same and uses thereof |
US20080216022A1 (en) * | 2005-01-16 | 2008-09-04 | Zlango Ltd. | Iconic Communication |
US20080082678A1 (en) * | 2005-01-16 | 2008-04-03 | Zlango Ltd. | Communications Network System and Methods for Using Same |
US8375327B2 (en) | 2005-01-16 | 2013-02-12 | Zlango Ltd. | Iconic communication |
US20090013087A1 (en) * | 2005-01-18 | 2009-01-08 | Zlango Ltd. | Communications Network System and Methods For Using Same |
US8019818B2 (en) | 2005-01-18 | 2011-09-13 | Zlango Ltd. | Communications network system and methods for using same |
US10335783B2 (en) | 2005-01-31 | 2019-07-02 | Realbio Technologies, Ltd. | Multistep reaction lateral flow capillary device |
EP2316441A1 (en) | 2005-02-17 | 2011-05-04 | Hadasit Medical Research Services And Development | Bisphosphonates for treating endometriosis |
WO2006090388A2 (en) | 2005-02-25 | 2006-08-31 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center | Fruit cell culture extract for treating inflammation |
US20060211064A1 (en) * | 2005-03-18 | 2006-09-21 | Hyesook Kim | Detection of hypertension using glucuronidated metabolic products |
US7695927B2 (en) | 2005-03-18 | 2010-04-13 | Detroit R & D | Detection of hypertension using glucuronidated metabolic products |
US20090068207A1 (en) * | 2005-04-15 | 2009-03-12 | Vascular Biogenics Ltd. | Compositions Containing Beta 2-Glycoprotein I-Derived Peptides for the Prevention and/or Treatment of Vascular Disease |
US8834862B2 (en) | 2005-04-19 | 2014-09-16 | Nanocyte Inc. | Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent |
US20060234203A1 (en) * | 2005-04-19 | 2006-10-19 | Nanocyte Inc. | Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent |
US9567568B2 (en) | 2005-05-04 | 2017-02-14 | Enlivex Therapeutics Ltd. | Method of preparing apoptotic monocytes |
EP2312315A1 (en) | 2005-05-18 | 2011-04-20 | Novartis AG | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
EP2279726A2 (en) | 2005-05-26 | 2011-02-02 | Biorest Ltd. | Compositions and methods using same for delivering agents into a target organ protected by a blood barrier |
EP2465924A2 (en) | 2005-06-16 | 2012-06-20 | Ramot at Tel-Aviv University Ltd. | Isolated cells and populations comprising same for the treament of cns diseases |
WO2006134602A2 (en) | 2005-06-16 | 2006-12-21 | Ramot At Tel Aviv University Ltd. | Isolated cells and populations comprising same for the treatment of cns diseases |
US20070225242A1 (en) * | 2005-06-21 | 2007-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method and composition for treating and preventing tumor metastasis in vivo |
US20060292559A1 (en) * | 2005-06-23 | 2006-12-28 | Beckman Coulter, Inc. | Cell-based microarrays, and methods for their preparation and use |
EP2487182A2 (en) | 2005-07-07 | 2012-08-15 | FULCRUM SP Ltd. | SP1 polypeptides, modified SP1 polypeptides and uses thereof |
US8067574B2 (en) | 2005-07-07 | 2011-11-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acid agents for downregulating H19, and methods of using same |
US8067573B2 (en) | 2005-07-07 | 2011-11-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acid agents for downregulating H19 and methods of using same |
US20090143321A1 (en) * | 2005-07-07 | 2009-06-04 | Avraham Hochberg | Nucleic acid agents for downregulating h19 and methods of using same |
EP2484768A2 (en) | 2005-07-18 | 2012-08-08 | Protalix Ltd. | Mucosal or enteral administration of biologically active macromolecules |
EP2441840A1 (en) | 2005-07-18 | 2012-04-18 | Protalix Ltd. | Mucosal or enteral administration of biologically active macromolecules |
EP2889041A1 (en) | 2005-07-26 | 2015-07-01 | Rutgers, The State University of New Jersey | Kit of reagents for tuberculosis assay |
US20100068135A1 (en) * | 2005-08-08 | 2010-03-18 | Onconon, Llc | Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility |
US8642330B2 (en) | 2005-08-08 | 2014-02-04 | Onconon, Llc | Antibody compositions, methods for treating neoplastic disease and methods for regulating fertility |
WO2007020638A2 (en) | 2005-08-15 | 2007-02-22 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
EP2995194A1 (en) | 2005-08-15 | 2016-03-16 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
US20110126323A1 (en) * | 2005-08-15 | 2011-05-26 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
US9487796B2 (en) | 2005-08-15 | 2016-11-08 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
US7910800B2 (en) | 2005-08-15 | 2011-03-22 | Evogene Ltd. | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
US20090089898A1 (en) * | 2005-08-15 | 2009-04-02 | Hagai Karchi | Methods of increasing abiotic stress tolerance and/or biomass in plants and plants generated thereby |
WO2007023491A2 (en) | 2005-08-24 | 2007-03-01 | Yeda Research And Development Co. Ltd. | Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance |
EP2514315A2 (en) | 2005-08-24 | 2012-10-24 | Yeda Research and Development Co. Ltd. | Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance |
EP3354723A1 (en) | 2005-08-29 | 2018-08-01 | Technion Research & Development Foundation Ltd. | Media for culturing stem cells |
WO2007031996A1 (en) | 2005-09-12 | 2007-03-22 | Rappaport Family Institute For Research In The Medical Sciences | Compositions and methods for diagnosing and treating an inflammation |
US8034914B2 (en) | 2005-09-22 | 2011-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer |
WO2007034487A1 (en) | 2005-09-22 | 2007-03-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer |
US20090221681A1 (en) * | 2005-09-22 | 2009-09-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acid constructs, pharmaceutical compositions and methods of using same for treating cancer |
US20070087437A1 (en) * | 2005-10-14 | 2007-04-19 | Jifan Hu | Methods for rejuvenating cells in vitro and in vivo |
EP2716654A1 (en) | 2005-10-24 | 2014-04-09 | Evogene Ltd. | Isolated polypeptides, polynucleotides encoding same, transgenic plants expressing same and methods of using same |
EP2390312A1 (en) | 2005-11-29 | 2011-11-30 | Gamida Cell Ltd. | Methods of improving stem cell homing and engraftment |
US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
US8775526B2 (en) | 2006-01-16 | 2014-07-08 | Zlango Ltd. | Iconic communication |
EP2368569A2 (en) | 2006-01-18 | 2011-09-28 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
EP2368570A2 (en) | 2006-01-18 | 2011-09-28 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
US7553941B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting polypeptides and methods of producing same |
US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
EP3202779A2 (en) | 2006-02-03 | 2017-08-09 | OPKO Biologics Ltd. | Long-acting hgh polypeptides and uses thereof |
US9828417B2 (en) | 2006-02-03 | 2017-11-28 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US9884901B2 (en) | 2006-02-03 | 2018-02-06 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
WO2007094985A2 (en) | 2006-02-03 | 2007-08-23 | Modigene Inc | Long-acting polypeptides and methods of producing and administering same |
US20070190610A1 (en) * | 2006-02-03 | 2007-08-16 | Fuad Fares | Long-acting EPO polypeptides and derivatives thereof and methods thereof |
US8465948B2 (en) | 2006-02-03 | 2013-06-18 | Prolor Biotech Ltd. | Long-acting veterinary polypeptides and methods of producing and administering same |
US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
US8426166B2 (en) | 2006-02-03 | 2013-04-23 | Prolor Biotech Inc. | Long-acting polypeptides and methods of producing same |
US9896494B2 (en) | 2006-02-03 | 2018-02-20 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing same |
US9908924B2 (en) | 2006-02-03 | 2018-03-06 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US10030060B2 (en) | 2006-02-03 | 2018-07-24 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing same |
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US20070190611A1 (en) * | 2006-02-03 | 2007-08-16 | Fuad Fares | Long-acting polypeptides and methods of producing same |
US20070184530A1 (en) * | 2006-02-03 | 2007-08-09 | Fuad Fares | Long-acting veterinary polypeptides and methods of producing and administering same |
US10119132B2 (en) | 2006-02-03 | 2018-11-06 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US10144921B2 (en) | 2006-02-03 | 2018-12-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US11066658B2 (en) | 2006-02-03 | 2021-07-20 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
EP2532674A1 (en) | 2006-02-03 | 2012-12-12 | Modigene Inc | Long-acting polypeptides and methods of producing and administering same |
EP3663312A1 (en) | 2006-02-03 | 2020-06-10 | OPKO Biologics Ltd. | Long-acting polypeptides and uses thereof |
EP2532675A1 (en) | 2006-02-03 | 2012-12-12 | Modigene Inc | Long-acting polypeptides and methods of producing and administering same |
US8323636B2 (en) | 2006-02-03 | 2012-12-04 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
US10640758B2 (en) | 2006-02-03 | 2020-05-05 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US8999670B2 (en) | 2006-02-03 | 2015-04-07 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing same |
US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
EP2853536A1 (en) | 2006-02-03 | 2015-04-01 | OPKO Biologics Ltd. | Long-acting erythropoietin polypeptides and uses thereof |
US7553940B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting EPO polypeptides and derivatives thereof and methods thereof |
EP2471807A1 (en) | 2006-02-03 | 2012-07-04 | Modigene Inc | Long-acting polypeptides and methods of producing and administering same |
EP2853541A1 (en) | 2006-02-03 | 2015-04-01 | OPKO Biologics Ltd. | Long-acting polypeptides and uses thereof |
WO2007091254A1 (en) | 2006-02-06 | 2007-08-16 | Rappaport Family Institute For Research In The Medical Sciences | Methods and kit for diagnosing t1dm |
US9057092B2 (en) | 2006-03-06 | 2015-06-16 | Zetiq Technologies Ltd. | Methods and compositions for identifying a cell phenotype |
US10018622B2 (en) | 2006-03-06 | 2018-07-10 | Zetiq Technologies Ltd. | Methods and kits for differential staining of abnormal urinary system cells |
EP2366775A1 (en) | 2006-03-23 | 2011-09-21 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
EP2626417A1 (en) | 2006-03-23 | 2013-08-14 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
EP2548951A1 (en) | 2006-03-23 | 2013-01-23 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
EP3091071A1 (en) | 2006-03-23 | 2016-11-09 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
WO2007110869A2 (en) | 2006-03-28 | 2007-10-04 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods and kits for determining predisposition to warfarin resistance |
US8071323B2 (en) | 2006-04-07 | 2011-12-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human monoclonal antibodies that bind human insulin like growth factors and their use |
US20100055033A1 (en) * | 2006-04-07 | 2010-03-04 | The Government Of The United States Of America As Represented By The Secretary | Antibody compositions and methods for treatment of neoplastic disease |
WO2007124299A2 (en) | 2006-04-21 | 2007-11-01 | Novartis Ag | Antagonist anti-cd40 antibody pharmaceutical compositions |
US20110150874A1 (en) * | 2006-05-19 | 2011-06-23 | Teva Pharmaceutical Industries Ltd. | Fusion proteins, uses thereof and processes for producing same |
US20070281883A1 (en) * | 2006-06-05 | 2007-12-06 | Hanna Rosenfeld | Development of follicle stimulating hormone agonists and antagonists in fish |
WO2008010228A2 (en) | 2006-07-20 | 2008-01-24 | Yeda Research And Development Co. Ltd. | Photosyntheticorganisms and compositions and methods of generating same |
WO2008026198A2 (en) | 2006-08-28 | 2008-03-06 | Yeda Research And Development Co. Ltd. | Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns |
US8158371B2 (en) | 2006-09-08 | 2012-04-17 | Wisconsin Alumni Research Foundation | Assay for antibodies to Mycobacterium paratuberculosis |
US20110027812A1 (en) * | 2006-09-08 | 2011-02-03 | Wisconsin Alumni Research Foundation | Assay for antibodies to mycobacterium paratuberculosis |
US20080138840A1 (en) * | 2006-09-08 | 2008-06-12 | Collins Michael T | Assay for antibodies to mycobacterium paratuberculosis |
US20080199895A1 (en) * | 2006-10-05 | 2008-08-21 | Yeda Research And Development Co. Ltd. | Highly purified and stabilized Na,K-ATPase isoforms and methods of producing same |
WO2008041183A2 (en) | 2006-10-05 | 2008-04-10 | Technion Research & Development Foundation Ltd. | Microtubes and methods of producing same |
EP2383345A1 (en) | 2006-12-20 | 2011-11-02 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
US8168857B2 (en) | 2006-12-20 | 2012-05-01 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
US9631000B2 (en) | 2006-12-20 | 2017-04-25 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
US20090293146A1 (en) * | 2006-12-20 | 2009-11-26 | Evogene Ltd. | Polynucleotides and polypeptides involved in plant fiber development and methods of using same |
EP2860189A2 (en) | 2007-01-04 | 2015-04-15 | Institute for Research in Biomedicine | Human cytomegalovirus neutralising antibodies and use thereof |
EP2487187A2 (en) | 2007-01-04 | 2012-08-15 | Institute for Research in Biomedicine | Human cytomegalovirus neutralising antibodies and use thereof |
WO2008084410A2 (en) | 2007-01-04 | 2008-07-17 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
US20100105759A1 (en) * | 2007-01-16 | 2010-04-29 | Abraham Hochberg | H19 silencing nucleic acid agents for treating rheumatoid arthritis |
US7928083B2 (en) | 2007-01-16 | 2011-04-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | H19 silencing nucleic acid agents for treating rheumatoid arthritis |
US20100196403A1 (en) * | 2007-01-29 | 2010-08-05 | Jacob Hochman | Antibody conjugates for circumventing multi-drug resistance |
WO2008093341A2 (en) | 2007-01-31 | 2008-08-07 | Technion Research & Development Foundation Ltd. | Electrospun scaffolds and methods of generating and using same |
EP2478924A1 (en) | 2007-02-01 | 2012-07-25 | Technion Research & Development Foundation | Albumin fibers and fabrics and methods of generating and using same |
WO2008093342A2 (en) | 2007-02-01 | 2008-08-07 | Technion Research & Development Foundation Ltd. | Albumin fibers and fabrics and methods of generating and using same |
US8728481B2 (en) | 2007-02-02 | 2014-05-20 | Baylor Research Institute | Agents that engage antigen-presenting cells through dendritic cell asialoglycoprotein receptor (DC-ASGPR) |
US7786267B2 (en) | 2007-02-02 | 2010-08-31 | Baylor Research Institute | Multivariable antigens complexed with targeting humanized monoclonal antibody |
US10279030B2 (en) | 2007-02-02 | 2019-05-07 | Baylor Research Institute | Agents that engage antigen-presenting cells through dendritic cell asialoglycoprotein receptor (DC-ASGPR) |
US20080206262A1 (en) * | 2007-02-02 | 2008-08-28 | Baylor Research Institute | Agents That Engage Antigen-Presenting Cells Through Dendritic Cell Asialoglycoprotein Receptor (DC-ASGPR) |
US11173202B2 (en) | 2007-02-02 | 2021-11-16 | Baylor Research Institute | Agents that engage antigen-presenting cells through dendritic cell asialoglycoprotein receptor (DC-ASGPR) |
US9102730B2 (en) | 2007-02-02 | 2015-08-11 | Baylor Research Institute | Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells |
EP2684889A2 (en) | 2007-02-02 | 2014-01-15 | Baylor Research Institute | Multivariable antigens complexed with targeting humanized monoclonal antibody |
US8586052B2 (en) | 2007-02-02 | 2013-11-19 | Baylor Research Institute | Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells |
US20100330115A1 (en) * | 2007-02-02 | 2010-12-30 | Baylor Research Institute | Multivariable Antigens Complexed with Targeting Humanized Monoclonal Antibody |
US20080254044A1 (en) * | 2007-02-02 | 2008-10-16 | Baylor Research Institute | Multivariable Antigens Complexed with Targeting Humanized Monoclonal Antibody |
US9453074B2 (en) | 2007-02-02 | 2016-09-27 | Baylor Research Institute | Agents that engage antigen-presenting cells through dendritic cell asialoglycoprotein receptor (DC-ASGPR) |
US20080241170A1 (en) * | 2007-02-02 | 2008-10-02 | Baylor Research Institute | Vaccines Based on Targeting Antigen to DCIR Expressed on Antigen-Presenting Cells |
US8236934B2 (en) | 2007-02-02 | 2012-08-07 | Baylore Research Institute | Agents that engage antigen-presenting cells through dendritic cell asialoglycoprotein receptor (DC-ASGPR) |
US8057798B2 (en) | 2007-02-02 | 2011-11-15 | Baylor Research Institute | Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells |
US9234040B2 (en) | 2007-02-02 | 2016-01-12 | Baylor Research Institute | Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells |
WO2008097870A2 (en) | 2007-02-02 | 2008-08-14 | Baylor Research Institute | Agents that engage antigen - presenting cells through dendritic cell asialoglycoprotein receptor (dc- asgpr) |
EP2527363A1 (en) | 2007-02-02 | 2012-11-28 | Baylor Research Institute | Vaccines based on targeting antigen to dcir expressed on antigen-presenting cells |
US8449888B2 (en) | 2007-02-02 | 2013-05-28 | Baylor Research Institute | Vaccines based on targeting antigen to DCIR expressed on antigen-presenting cells |
US20080267984A1 (en) * | 2007-02-23 | 2008-10-30 | Baylor Research Institute | Activation of Human Antigen-Presenting Cells Through Dendritic Cell Lectin-Like Oxidized LDL Receptor-1 (LOX-1) |
US9339556B2 (en) | 2007-02-23 | 2016-05-17 | Baylor Research Institute | Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized LDL receptor-1 (LOX-1) |
EP3489260A1 (en) | 2007-02-23 | 2019-05-29 | Baylor Research Institute | Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized ldl receptor-1 (lox-1) |
US20080254047A1 (en) * | 2007-02-23 | 2008-10-16 | Baylor Research Institute | Activation of Human Antigen-Presenting Cells Through CLEC-6 |
EP2522718A1 (en) | 2007-02-23 | 2012-11-14 | Baylor Research Institute | Therapeutic applications of activation of human antigen-presenting cells through dectin-1 |
US20080233140A1 (en) * | 2007-02-23 | 2008-09-25 | Baylor Research Institute | Therapeutic Applications of Activation of Human Antigen-Presenting Cells Through Dectin-1 |
US8481314B2 (en) | 2007-02-23 | 2013-07-09 | Baylor Research Institute | Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized LDL receptor-1 (LOX-1) |
EP2839839A1 (en) | 2007-02-28 | 2015-02-25 | Yeda Research And Development Company Limited | Nuclear targeting sequences |
WO2008120202A2 (en) | 2007-03-29 | 2008-10-09 | Technion Research & Development Foundation Ltd. | Antibodies, methods and kits for diagnosing and treating melanoma |
EP2514766A2 (en) | 2007-03-29 | 2012-10-24 | Technion Research & Development Foundation Ltd. | Antibodies, methods and kits for diagnosing and treating melanoma |
WO2008120216A1 (en) | 2007-04-02 | 2008-10-09 | Ramot At Tel Aviv University Ltd. | Methods of detecting cancer cells and use of same for diagnosing and monitoring treatment of the disease |
US8513488B2 (en) | 2007-04-09 | 2013-08-20 | Evogene Ltd. | Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants |
US9487793B2 (en) | 2007-04-09 | 2016-11-08 | Evogene Ltd. | Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants |
US20100154077A1 (en) * | 2007-04-09 | 2010-06-17 | Evogene Ltd. | Polynucleotides, polypeptides and methods for increasing oil content, growth rate and biomass of plants |
US9556210B2 (en) | 2007-04-23 | 2017-01-31 | Sabag-Rfa Ltd. | System for delivering therapeutic agents into living cells and cells nuclei |
US9156865B2 (en) | 2007-04-23 | 2015-10-13 | Deliversir Ltd | System for delivering therapeutic agents into living cells and cells nuclei |
US8293209B2 (en) | 2007-04-23 | 2012-10-23 | Segev Laboratories Limited | System for delivering therapeutic agents into living cells and cells nuclei |
US20100092386A1 (en) * | 2007-04-23 | 2010-04-15 | David Segev | System for delivering therapeutic agents into living cells and cells nuclei |
WO2008132753A2 (en) | 2007-05-01 | 2008-11-06 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods and kits for detecting fetal cells in the maternal blood |
EP3032259A1 (en) | 2007-05-01 | 2016-06-15 | Tel Hashomer Medical Research Infrastructure and Services Ltd. | Methods for detecting trophoblast cells in maternal blood based on cytokeratin-7 |
EP3360571A1 (en) | 2007-05-03 | 2018-08-15 | Agency For Science, Technology And Research (A*star) | Antibodies binding to an intracellular prl-1 or prl-3 polypeptide |
EP2529754A1 (en) | 2007-05-03 | 2012-12-05 | Agency For Science, Technology And Research (A*star) | Antibodies binding to an intracellular PRL-1 or PRL-3 polypeptide |
EP3366762A1 (en) | 2007-05-07 | 2018-08-29 | Protalix Ltd. | Large scale disposable bioreactor |
EP2500428A2 (en) | 2007-07-11 | 2012-09-19 | Yeda Research and Development Co. Ltd. | Nucleic acid construct systems capable of diagnosing or treating a cell state |
EP2527441A2 (en) | 2007-07-15 | 2012-11-28 | Technion Research & Development Foundation | Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis |
WO2009010968A2 (en) | 2007-07-15 | 2009-01-22 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
EP3075854A1 (en) | 2007-07-15 | 2016-10-05 | Technion Research & Development Foundation Ltd. | Compositions and methods for treating tumors, fibrosis, and pulmonary alveolar proteinosis |
US9518267B2 (en) | 2007-07-24 | 2016-12-13 | Evogene Ltd. | Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same |
US8686227B2 (en) | 2007-07-24 | 2014-04-01 | Evogene Ltd. | Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same |
EP2910638A2 (en) | 2007-07-24 | 2015-08-26 | Evogene Ltd. | Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same |
US20100319088A1 (en) * | 2007-07-24 | 2010-12-16 | Gil Ronen | Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same |
US20090053224A1 (en) * | 2007-08-02 | 2009-02-26 | Arresto Biosciences | Lox and loxl2 inhibitors and uses thereof |
US10494443B2 (en) | 2007-08-02 | 2019-12-03 | Gilead Biologics, Inc. | LOX and LOXL2 inhibitors and uses thereof |
US8658167B2 (en) | 2007-08-02 | 2014-02-25 | Gilead Biologics, Inc. | Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis |
US20090104201A1 (en) * | 2007-08-02 | 2009-04-23 | Victoria Smith | Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis |
US9176139B2 (en) | 2007-08-02 | 2015-11-03 | Gilead Biologics, Inc. | LOX and LOXL2 inhibitors and uses thereof |
US8679485B2 (en) | 2007-08-02 | 2014-03-25 | Gilead Biologics, Inc. | Methods and compositions for treatment and diagnosis of fibrosis, tumor invasion, angiogenesis, and metastasis |
US8461303B2 (en) | 2007-08-02 | 2013-06-11 | Gilead Biologics, Inc. | LOX and LOXL2 inhibitors and uses thereof |
EP2581445A1 (en) | 2007-08-15 | 2013-04-17 | Yeda Research And Development Co. Ltd. | Regulators of MMP-9 and uses thereof |
WO2009034574A2 (en) | 2007-09-12 | 2009-03-19 | Yeda Research And Development Co. Ltd. | Methods of treating tumors in immune-privileged sites |
US20090068669A1 (en) * | 2007-09-12 | 2009-03-12 | Elias Georges | Slc9a3r1 directed diagnostics for neoplastic disease |
EP2591789A2 (en) | 2007-09-19 | 2013-05-15 | Pluristem Ltd. | Adherent cells from adipose or placenta tissues and use thereof in therapy |
EP3103463A1 (en) | 2007-09-19 | 2016-12-14 | Pluristem Ltd. | Adherent cells from adipose or placenta tissues and use thereof in therapy |
EP2050826A2 (en) | 2007-10-16 | 2009-04-22 | Roche Diagnostics GmbH | Reagents and methods for detecting neisseria gonorrhoeae |
EP2781223A1 (en) | 2007-10-19 | 2014-09-24 | Rappaport Family Institute for Research in the Medical Sciences | Compositions comprising semaphorins for the treatment of angiogenesis related diseases |
US20110177112A1 (en) * | 2007-11-02 | 2011-07-21 | The Johns Hopkins University | Multi- component l2 vaccine for prevention of human papilloma virus infection |
US9138470B2 (en) | 2007-11-02 | 2015-09-22 | The Johns Hopkins University | Multi-component L2 vaccine for prevention of human papilloma virus infection |
EP2599790A1 (en) | 2007-11-26 | 2013-06-05 | Yissum Research Development Company of The Hebrew University of Jerusalem | Compositions comprising fibrous polypeptides and polysachharides |
EP2071021A2 (en) | 2007-12-12 | 2009-06-17 | University of South Florida | Bone marrow-derived neuronal cells |
US9670501B2 (en) | 2007-12-27 | 2017-06-06 | Evogene Ltd. | Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress tolerance, yield and biomass in plants |
US8426682B2 (en) | 2007-12-27 | 2013-04-23 | Evogene Ltd. | Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress tolerance, yield and biomass in plants |
WO2009083958A2 (en) | 2007-12-27 | 2009-07-09 | Evogene Ltd. | Isolated polypeptides, polynucleotides useful for modifying water user efficiency, fertilizer use efficiency, biotic/abiotic stress tolerance, yield and biomass in plants |
US20090233295A1 (en) * | 2008-01-29 | 2009-09-17 | Elias Georges | Trim59 directed diagnostics for neoplastic disease |
US20110052501A1 (en) * | 2008-01-31 | 2011-03-03 | Liat Dassa | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
WO2009104174A2 (en) | 2008-02-21 | 2009-08-27 | Technion Research & Development Foundation Ltd . | A method of attaching a cell-of-interest to a microtube |
US8153383B2 (en) | 2008-03-18 | 2012-04-10 | Wisconsin Alumni Research Foundation | Mycobacterial culture screening test for Mycobacterium avium complex bacteria |
US20090305302A1 (en) * | 2008-03-18 | 2009-12-10 | Collins Michael T | Mycobacterial culture screening test for mycobacterium avium complex bacteria |
US8747855B2 (en) | 2008-04-09 | 2014-06-10 | Technion Research & Development Foundation Limited | Anti human immunodeficiency antibodies and uses thereof |
US20110020357A1 (en) * | 2008-04-09 | 2011-01-27 | Technion Research & Development Foundation Ltd. | Anti human immunodeficiency antibodies and uses thereof |
US20110033473A1 (en) * | 2008-04-09 | 2011-02-10 | Yoram Reiter | Anti influenza antibodies and uses thereof |
US9132587B2 (en) | 2008-04-10 | 2015-09-15 | Stratasys Ltd. | System and method for three dimensional model printing |
US20110147993A1 (en) * | 2008-04-10 | 2011-06-23 | Objet Geometries Ltd. | System and method for three dimensional model printing |
EP3020410A1 (en) | 2008-04-18 | 2016-05-18 | Collplant Ltd. | Methods of generating and using procollagen |
EP2936976A1 (en) | 2008-04-21 | 2015-10-28 | Danziger Innovations Ltd. | Plant viral expression vectors and use of same for generating genotypic variations in plant genomes |
EP2116618A1 (en) | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnosis and treatment of Kawasaki disease |
US8847008B2 (en) | 2008-05-22 | 2014-09-30 | Evogene Ltd. | Isolated polynucleotides and polypeptides and methods of using same for increasing plant utility |
US20110097771A1 (en) * | 2008-05-22 | 2011-04-28 | Eyal Emmanuel | Isolated polynucleotides and polypeptides and methods of using same for increasing plant utility |
EP2641606A1 (en) | 2008-05-27 | 2013-09-25 | Pluristem Ltd. | Methods of treating inflammatory colon diseases |
EP2620493A1 (en) | 2008-05-28 | 2013-07-31 | Ramot at Tel Aviv University Ltd. | Mesenchymal stem cells for the treatment of CNS diseases |
EP3514229A1 (en) | 2008-05-28 | 2019-07-24 | Ramot at Tel-Aviv University Ltd. | Mesenchymal stem cells for the treatment of cns diseases |
US9952211B2 (en) | 2008-06-29 | 2018-04-24 | Realbio Technologies Ltd. | Liquid-transfer device particularly useful as a capturing device in a biological assay process |
US11280785B2 (en) | 2008-06-29 | 2022-03-22 | Realbio Technologies Ltd. | Liquid-transfer device particularly useful as a capturing device in a biological assay process |
US9109011B2 (en) | 2008-07-16 | 2015-08-18 | Baylor Research Institute | Dendritic cell-specific antibody conjugate comprising anti-CD40 monoclonal antibodies conjugated to HIV-1 Gag/Nef |
EP3009449A1 (en) | 2008-07-16 | 2016-04-20 | Institute for Research in Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
EP3178845A1 (en) | 2008-07-16 | 2017-06-14 | Institute for Research in Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
US20100135994A1 (en) * | 2008-07-16 | 2010-06-03 | Baylor Research Institute | Hiv vaccine based on targeting maximized gag and nef to dendritic cells |
EP2960250A1 (en) | 2008-07-16 | 2015-12-30 | Institute for Research in Biomedicine | Human cytomegalovirus neutralising antibodies and use thereof |
EP2966091A1 (en) | 2008-07-16 | 2016-01-13 | Baylor Research Institute | Agonistic anti-cd40 antibodies |
EP3388450A1 (en) | 2008-07-16 | 2018-10-17 | Baylor Research Institute | Hiv vaccine based on targeting maximized gag and nef to dendritic cells |
US20100086555A1 (en) * | 2008-07-25 | 2010-04-08 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
US20100080813A1 (en) * | 2008-07-25 | 2010-04-01 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
US9340603B2 (en) | 2008-07-25 | 2016-05-17 | Institute For Research In Biomedicine | Neutralizing anti-influenza A virus antibodies and uses thereof |
US8685402B2 (en) | 2008-07-25 | 2014-04-01 | Institute For Research In Biomedicine | Neutralizing anti-influenza A virus antibodies and uses thereof |
WO2010016806A1 (en) | 2008-08-08 | 2010-02-11 | Agency For Science, Technology And Research (A*Star) | Vhz for diagnosis and treatment of cancers |
EP2657342A1 (en) | 2008-08-08 | 2013-10-30 | Genisphere Inc. | DNA dendrimers protected against nuclease degradation are useful as vectors for the delivery of siRNA |
WO2010017544A2 (en) | 2008-08-08 | 2010-02-11 | Genisphere, Inc. | Long-acting dna dendrimers and methods thereof |
EP3072972A2 (en) | 2008-08-18 | 2016-09-28 | Evogene Ltd. | Isolated polypeptides and polynucleotides useful for increasing nitrogen use efficiency, abiotic stress tolerance, yield and biomass in plants |
US9018445B2 (en) | 2008-08-18 | 2015-04-28 | Evogene Ltd. | Use of CAD genes to increase nitrogen use efficiency and low nitrogen tolerance to a plant |
US20110145946A1 (en) * | 2008-08-18 | 2011-06-16 | Evogene Ltd. | Isolated polypeptides and polynucleotides useful for increasing nitrogen use efficiency, abiotic stress tolerance, yield and biomass in plants |
EP3616504A2 (en) | 2008-08-18 | 2020-03-04 | Evogene Ltd. | Isolated polypeptides and polynucleotides useful for increasing nitrogen use efficiency, abiotic stress tolerance, yield and biomass in plants |
EP3115451A1 (en) | 2008-09-02 | 2017-01-11 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
US8367392B2 (en) | 2008-09-05 | 2013-02-05 | Transalgae Ltd. | Genetic transformation of algal and cyanobacteria cells by microporation |
US20100081177A1 (en) * | 2008-09-05 | 2010-04-01 | TransAlgae Ltd | Decreasing RUBISCO content of algae and cyanobacteria cultivated in high carbon dioxide |
WO2010029545A2 (en) | 2008-09-11 | 2010-03-18 | Ben Gurion University Of The Negev Research And Development Authority | Compositions and methods for treating s. pneumoniae infection |
WO2010031006A1 (en) | 2008-09-12 | 2010-03-18 | Cryopraxis Criobiologia Ltda. | Ischemic tissue cell therapy |
EP2789626A2 (en) | 2008-09-24 | 2014-10-15 | Tel Hashomer Medical Research Infrastructure and Services Ltd. | Peptides and compositions for prevention of cell adhesion and methods of using same |
EP3670524A1 (en) | 2008-09-24 | 2020-06-24 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Peptides and compositions for prevention of cell adhesion and methods of using same |
WO2010035261A2 (en) | 2008-09-29 | 2010-04-01 | Ben Gurion University Of The Negev Research And Development Authority | Amyloid beta-peptides and methods of use thereof |
WO2010042481A1 (en) | 2008-10-06 | 2010-04-15 | University Of Chicago | Compositions and methods related to bacterial eap, emp, and/or adsa proteins |
US20110197315A1 (en) * | 2008-10-30 | 2011-08-11 | Evogene Ltd. | Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield |
WO2010049897A2 (en) | 2008-10-30 | 2010-05-06 | Evogene Ltd. | Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficieny |
US8921658B2 (en) | 2008-10-30 | 2014-12-30 | Evogene Ltd. | Isolated polynucleotides encoding a MAP65 polypeptide and methods of using same for increasing plant yield |
WO2010055525A1 (en) | 2008-11-17 | 2010-05-20 | Technion Research & Development Foundation Ltd. | Method for predicting a patient's responsiveness to anti-folate therapy |
WO2010058396A1 (en) | 2008-11-19 | 2010-05-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A cd44vra antibody and diagnostic and therapeutic methods using same |
WO2010061383A1 (en) | 2008-11-26 | 2010-06-03 | Biodalia Microbiological Technologies Ltd. | A method of in-situ enrichment of foods with fructan |
WO2010064231A1 (en) | 2008-12-02 | 2010-06-10 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods of analyzing a-i rna editing and nucleic acid constructs capable of same |
WO2010064247A1 (en) | 2008-12-03 | 2010-06-10 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods and kits for determining predisposition to cancer |
EP2633854A1 (en) | 2008-12-05 | 2013-09-04 | Yeda Research And Development Co. Ltd. | miRNA-9 or miRNA-9* for use in treating MND |
WO2010071610A1 (en) | 2008-12-19 | 2010-06-24 | Agency For Science, Technology And Research (A*Star) | Severe chikungunya biomarkers |
WO2010076642A1 (en) | 2008-12-29 | 2010-07-08 | Tel Hashomer Medical Research, Infrastructure And Services Ltd | Peptides and compositions for prevention of cell adhesion and methods of using same |
WO2010076756A2 (en) | 2008-12-29 | 2010-07-08 | Evogene Ltd. | Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance, biomass and/or yield in plants expressing same |
EP2808402A2 (en) | 2008-12-29 | 2014-12-03 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Methods of predicting responsiveness to interferon treatment |
WO2010076788A2 (en) | 2008-12-29 | 2010-07-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection |
EP3244189A1 (en) | 2008-12-30 | 2017-11-15 | Jin Po Lee | Quantitative analyte assay device and method |
WO2010076794A1 (en) | 2008-12-31 | 2010-07-08 | Technion Research & Development Foundation Ltd. | Method of denitrifying brine and systems capable of same |
US9289447B2 (en) | 2009-01-06 | 2016-03-22 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
US20100209415A1 (en) * | 2009-01-06 | 2010-08-19 | Victoria Smith | Chemotherapeutic methods and compositions |
US9107935B2 (en) | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
US10093896B2 (en) | 2009-02-01 | 2018-10-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs |
WO2010086856A2 (en) | 2009-02-01 | 2010-08-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs |
WO2010086867A2 (en) | 2009-02-02 | 2010-08-05 | Ramot At Tel Aviv University Ltd. | Peptides, pharmaceutical compositions comprising same and uses thereof |
WO2010089707A1 (en) | 2009-02-04 | 2010-08-12 | Yeda Research And Development Co. Ltd. | Methods and kits for determining sensitivity or resistance of prostate cancer to radiation therapy |
EP2465920A2 (en) | 2009-02-26 | 2012-06-20 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Isolated populations of renal stem cells and methods of isolating and using same |
WO2010097794A1 (en) | 2009-02-26 | 2010-09-02 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods of reprogramming renal cells |
WO2010097793A2 (en) | 2009-02-26 | 2010-09-02 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Isolated populations of renal stem cells and methods of isolating and using same |
WO2010100595A2 (en) | 2009-03-02 | 2010-09-10 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics |
US8937220B2 (en) | 2009-03-02 | 2015-01-20 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield, biomass, vigor and/or growth rate of a plant |
EP3000889A2 (en) | 2009-03-02 | 2016-03-30 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics |
EP3026057A2 (en) | 2009-03-09 | 2016-06-01 | Ramot at Tel Aviv University Ltd. | Compositions for prevention and treatment of neurodegenerative diseases |
WO2010103517A1 (en) | 2009-03-12 | 2010-09-16 | Rappaport Family Institute For Research In The Medical Sciences | Soluble compositions for the treatment of cxcr3-ligand associated diseases |
WO2010113096A1 (en) | 2009-03-30 | 2010-10-07 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods of predicting clinical course and treating multiple sclerosis |
WO2010113146A1 (en) | 2009-04-01 | 2010-10-07 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | A method of regulating proliferation and differentiation of keratinocyes |
US9907850B2 (en) | 2009-04-03 | 2018-03-06 | The University Of Chicago | Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response |
US9212219B2 (en) | 2009-04-03 | 2015-12-15 | The University Of Chicago | Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response |
WO2011005341A2 (en) | 2009-04-03 | 2011-01-13 | University Of Chicago | Compositions and methods related to protein a (spa) variants |
EP3281947A1 (en) | 2009-04-03 | 2018-02-14 | The University of Chicago | Compositions and methods related to protein a (spa) variants |
EP3002293A1 (en) | 2009-04-03 | 2016-04-06 | The University of Chicago | Compositions and methods related to protein a (spa) variants |
WO2010116375A1 (en) | 2009-04-08 | 2010-10-14 | Yeda Research And Development Co. Ltd. | Isolated peptides for regulating apoptosis |
EP2990421A1 (en) | 2009-04-30 | 2016-03-02 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Anti ceacam1 antibodies and methods of using same |
US9182403B2 (en) | 2009-05-19 | 2015-11-10 | Zetiq Technologies Ltd. | Kits for and methods of differential staining of cervical cancer cells and/or tissues |
WO2010135663A2 (en) | 2009-05-21 | 2010-11-25 | The United States Of America , As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for the detection of hiv-1/hiv-2 infection |
WO2010137013A1 (en) | 2009-05-27 | 2010-12-02 | Ramot At Tel Aviv University Ltd. | Crystallized photosystem i units from the pea plant and their use in solid state devices |
WO2010137021A2 (en) | 2009-05-27 | 2010-12-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of generating connective tissue |
WO2010137017A2 (en) | 2009-05-27 | 2010-12-02 | Yeda Research And Development Co. Ltd. | Proteasome inhibitors and uses thereof |
WO2010137020A1 (en) | 2009-05-28 | 2010-12-02 | Yeda Research And Development Co. Ltd. | Methods of treating inflammation |
US9096865B2 (en) | 2009-06-10 | 2015-08-04 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance |
EP3238534A2 (en) | 2009-06-10 | 2017-11-01 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance |
EP3626051A2 (en) | 2009-06-10 | 2020-03-25 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance |
WO2010150259A1 (en) | 2009-06-24 | 2010-12-29 | Fund For Medical Research Development Of Infrastructure And Health Services -Rambam Medical Center | Methods and kits for isolating placental derived microparticles and use of same for diagnosis of fetal disorders |
EP3130346A1 (en) | 2009-07-09 | 2017-02-15 | OPKO Biologics Ltd. | Long-acting factor vii coagulation factors |
US10538755B2 (en) | 2009-07-09 | 2020-01-21 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
WO2011004361A2 (en) | 2009-07-09 | 2011-01-13 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
WO2011004379A1 (en) | 2009-07-10 | 2011-01-13 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Compositions and methods for treating cancer |
WO2011010309A1 (en) | 2009-07-21 | 2011-01-27 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | A method of diagnosing cancer |
US9574210B2 (en) | 2009-07-31 | 2017-02-21 | Ramot At Tel-Aviv University Ltd. | Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof |
WO2011013130A2 (en) | 2009-07-31 | 2011-02-03 | Ramot At Tel-Aviv University Ltd. | Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof |
US10179113B2 (en) | 2009-07-31 | 2019-01-15 | Ramot At Tel-Aviv University Ltd. | Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof |
WO2011021194A2 (en) | 2009-08-17 | 2011-02-24 | Technion Research & Development Foundation Ltd. | Pericyte progenitor cells and methods of generating and using same |
US8927700B2 (en) | 2009-08-21 | 2015-01-06 | Gilead Biologics, Inc. | Catalytic domains from lysyl oxidase and LOXL2 |
WO2011021171A1 (en) | 2009-08-21 | 2011-02-24 | Beeologics, Llc | Preventing and curing beneficial insect diseases via plant transcribed molecules |
US20110207144A1 (en) * | 2009-08-21 | 2011-08-25 | Derek Marshall | In vitro screening assays |
US8512990B2 (en) | 2009-08-21 | 2013-08-20 | Gilead Biologics, Inc. | Catalytic domains from lysyl oxidase and LOXL2 |
US20110076272A1 (en) * | 2009-08-21 | 2011-03-31 | Victoria Smith | Therapeutic methods and compositions |
US20110044981A1 (en) * | 2009-08-21 | 2011-02-24 | Spangler Rhyannon | Methods and compositions for treatment of pulmonary fibrotic disorders |
US20110044907A1 (en) * | 2009-08-21 | 2011-02-24 | Derek Marshall | In vivo screening assays |
US20110076739A1 (en) * | 2009-08-21 | 2011-03-31 | Mccauley Scott | Catalytic domains from lysyl oxidase and loxl2 |
WO2011024172A2 (en) | 2009-08-27 | 2011-03-03 | Technion Research & Development Foundation Ltd. | Liposomal compositions and uses of same |
WO2011030336A1 (en) | 2009-09-08 | 2011-03-17 | Ramot At Tel-Aviv University Ltd. | Methods of diagnosing amyotrophic lateral sclerosis (als) |
WO2011030332A2 (en) | 2009-09-08 | 2011-03-17 | Yeda Research And Development Co. Ltd. | Methods for hematopoietic precursor mobilization |
WO2011030329A1 (en) | 2009-09-10 | 2011-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of treating tumors |
WO2011033511A1 (en) | 2009-09-17 | 2011-03-24 | Ramot At Tel-Aviv University Ltd. | Peptides for the treatment of oxidative stress related disorders |
WO2011033506A2 (en) | 2009-09-17 | 2011-03-24 | Yeda Research And Development Co. Ltd. | Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage |
US20110081706A1 (en) * | 2009-10-02 | 2011-04-07 | TransAlgae Ltd | Method and system for efficient harvesting of microalgae and cyanobacteria |
US10801028B2 (en) | 2009-10-14 | 2020-10-13 | Beeologics Inc. | Compositions for controlling Varroa mites in bees |
WO2011045796A1 (en) | 2009-10-14 | 2011-04-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions for controlling varroa mites in bees |
EP3272869A1 (en) | 2009-10-14 | 2018-01-24 | Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. | Compositions for controlling varroa mites in bees |
WO2011046570A1 (en) | 2009-10-16 | 2011-04-21 | The University Of Medicine And Dentistry Of New Jersey | Method for treating chronic nerve tissue injury using a cell therapy strategy |
WO2011048600A1 (en) | 2009-10-21 | 2011-04-28 | Danziger Innovations Ltd. | Generating genotypic variations in plant genomes by gamete infection |
WO2011055366A1 (en) | 2009-11-08 | 2011-05-12 | Medical Research & Development Fund For Health Services Bnai Zion Medical Center, The State Of Israel | Mo-1 conditional knock-out non-human animal and uses thereof |
EP4166652A1 (en) | 2009-11-12 | 2023-04-19 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
WO2011058557A1 (en) | 2009-11-12 | 2011-05-19 | Ramot At Tel-Aviv University Ltd. | Compositions comprising pedf and uses of same in the treatment and prevention of ovary-related syndromes |
WO2011058555A1 (en) | 2009-11-12 | 2011-05-19 | Yeda Research And Development Co. Ltd. | A method of editing dna in a cell and constructs capable of same |
EP3633025A1 (en) | 2009-11-12 | 2020-04-08 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
WO2011061736A1 (en) | 2009-11-17 | 2011-05-26 | Protalix Ltd. | Alkaline alpha galactosidase for the treatment of fabry disease |
WO2011063198A2 (en) | 2009-11-20 | 2011-05-26 | St. Jude Children's Research Hospital | Methods and compositions for modulating the activity of the interleukin-35 receptor complex |
WO2011064773A1 (en) | 2009-11-24 | 2011-06-03 | Collplant Ltd. | Method of generating collagen fibers |
WO2011064669A2 (en) | 2009-11-30 | 2011-06-03 | Pluristem Ltd. | Adherent cells from placenta and use of same in disease treatment |
EP2977445A2 (en) | 2009-11-30 | 2016-01-27 | Pluristem Ltd. | Adherent cells from placenta and use of same in disease treatment |
EP2806023A2 (en) | 2009-11-30 | 2014-11-26 | Pluristem Ltd. | Adherent cells from placenta and use of same in disease treatment |
US9562235B2 (en) | 2009-12-06 | 2017-02-07 | A.B. Seeds Ltd. | MicroRNA compositions and methods for enhancing plant resistance to abiotic stress |
WO2011067745A2 (en) | 2009-12-06 | 2011-06-09 | Rosetta Green Ltd. | Compositions and methods for enhancing plants resistance to abiotic stress |
EP2862929A1 (en) | 2009-12-09 | 2015-04-22 | Quark Pharmaceuticals, Inc. | Compositions and methods for treating diseases, disorders or injury of the CNS |
WO2011072091A1 (en) | 2009-12-09 | 2011-06-16 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the cns |
US9493785B2 (en) | 2009-12-28 | 2016-11-15 | Evogene Ltd. | Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency |
WO2011080674A2 (en) | 2009-12-28 | 2011-07-07 | Evogene Ltd. | Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency |
EP3056569A2 (en) | 2009-12-28 | 2016-08-17 | Evogene Ltd. | Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency |
WO2011080740A1 (en) | 2009-12-29 | 2011-07-07 | Gamida-Cell Ltd. | Methods for enhancing natural killer cell proliferation and activity |
EP3184109A1 (en) | 2009-12-29 | 2017-06-28 | Gamida-Cell Ltd. | Methods for enhancing natural killer cell proliferation and activity |
EP3785712A1 (en) | 2009-12-29 | 2021-03-03 | Gamida-Cell Ltd. | Methods for enhancing natural killer cell proliferation and activity |
EP3159405A1 (en) | 2010-01-05 | 2017-04-26 | Vascular Biogenics Ltd. | Methods for use of a specific anti-angiogenic adenoviral agent |
WO2011086509A1 (en) | 2010-01-12 | 2011-07-21 | Vascular Biogenics Ltd. | Methods of producing adenovirus vectors and viral preparations generated thereby |
WO2011092700A1 (en) | 2010-01-27 | 2011-08-04 | Yeda Research And Development Co. Ltd. | Antibodies that inhibit metalloproteins |
EP3216805A1 (en) | 2010-01-27 | 2017-09-13 | Yeda Research and Development Co. Ltd | Antibodies that inhibit metalloproteins |
US8680246B2 (en) | 2010-02-04 | 2014-03-25 | Gilead Biologics, Inc. | Antibodies that bind to lysyl oxidase-like 2 (LOXL2) |
WO2011099006A2 (en) | 2010-02-11 | 2011-08-18 | Yeda Research And Development Co. Ltd. | Enzymatic systems for carbon fixation and methods of generating same |
US10080799B2 (en) | 2010-02-12 | 2018-09-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and compositions related to glycoprotein-immunoglobulin fusions |
WO2011104708A2 (en) | 2010-02-24 | 2011-09-01 | Ben Gurion University Of The Negev Research And Development Authority | Methods for inhibiting necrosis |
WO2011107939A1 (en) | 2010-03-01 | 2011-09-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of predicting efficacy of an anti-vegfa treatment for solid tumors |
WO2011107994A1 (en) | 2010-03-04 | 2011-09-09 | Yeda Research And Development Co. Ltd. | Methods of measuring protein stability |
US9988634B2 (en) | 2010-03-08 | 2018-06-05 | Monsanto Technology Llc | Polynucleotide molecules for gene regulation in plants |
US11812738B2 (en) | 2010-03-08 | 2023-11-14 | Monsanto Technology Llc | Polynucleotide molecules for gene regulation in plants |
WO2011111034A1 (en) | 2010-03-08 | 2011-09-15 | Yeda Research And Development Co. Ltd. | Recombinant protein production in heterologous systems |
US9121022B2 (en) | 2010-03-08 | 2015-09-01 | Monsanto Technology Llc | Method for controlling herbicide-resistant plants |
WO2011111050A2 (en) | 2010-03-11 | 2011-09-15 | Jacob Edrei | Methods of generating hydrogen |
WO2011125015A2 (en) | 2010-04-05 | 2011-10-13 | Bar-Ilan University | Protease-activatable pore-forming polypeptides |
WO2011127032A1 (en) | 2010-04-05 | 2011-10-13 | University Of Chicago | Compositions and methods related to protein a (spa) antibodies as an enhancer of immune response |
US8808699B2 (en) | 2010-04-05 | 2014-08-19 | The University Of Chicago | Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response |
US9458438B2 (en) | 2010-04-12 | 2016-10-04 | Ben Gurion University Of The Negev Research And Development Authority | Sulfotransferase of a red microalga and uses thereof |
WO2011128897A1 (en) | 2010-04-12 | 2011-10-20 | Technion Research & Development Foundation Ltd. | Populations of pancreatic progenitor cells and methods of isolating and using same |
WO2011132182A1 (en) | 2010-04-18 | 2011-10-27 | Yeda Research And Development Co. Ltd. | MOLECULES AND METHODS OF USING SAME FOR TREATING ErbB/ErbB LIGANDS ASSOCIATED DISEASES |
US9328353B2 (en) | 2010-04-28 | 2016-05-03 | Evogene Ltd. | Isolated polynucleotides and polypeptides for increasing plant yield and/or agricultural characteristics |
WO2011135527A2 (en) | 2010-04-28 | 2011-11-03 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics |
WO2011138778A2 (en) | 2010-05-04 | 2011-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of identifying inhibitors of polypeptides-of-interest |
WO2011138785A2 (en) | 2010-05-05 | 2011-11-10 | Rappaport Family Institute For Research In The Medical Sciences | Use of ccl1 in therapy |
WO2011138776A2 (en) | 2010-05-06 | 2011-11-10 | Hervana Ltd. | Biologic female contraceptives |
WO2011141914A1 (en) | 2010-05-13 | 2011-11-17 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Isolated populations of adult renal cells and methods of isolating and using same |
WO2011151833A1 (en) | 2010-06-03 | 2011-12-08 | Ramot At Tel-Aviv University Ltd. | Methods of treating diabetes and compositions capable of same |
WO2011154940A1 (en) | 2010-06-07 | 2011-12-15 | Osnat Ashur-Fabian | Methods and kits for diagnosing conditions related to hypoxia |
WO2011158242A2 (en) | 2010-06-16 | 2011-12-22 | Futuragene Israel Ltd. | Pest -resistant plants containing a combination of a spider toxin and a chitinase |
WO2011158243A2 (en) | 2010-06-16 | 2011-12-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of diagnosing and treating cancer |
WO2012003474A2 (en) | 2010-07-02 | 2012-01-05 | The University Of Chicago | Compositions and methods related to protein a (spa) variants |
WO2012007945A2 (en) | 2010-07-12 | 2012-01-19 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center | Isolated polynucleotides and methods and plants using same for regulating plant acidity |
WO2012007950A2 (en) | 2010-07-15 | 2012-01-19 | Technion Research & Development Foundation Ltd. | Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and diabetes-associated autoantigenic peptides |
WO2012007919A2 (en) | 2010-07-15 | 2012-01-19 | Technion Research & Development Foundation Ltd. | Nucleic acid construct for increasing abiotic stress tolerance in plants |
WO2012007951A1 (en) | 2010-07-15 | 2012-01-19 | Technion Research & Development Foundation Ltd. | Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and glutamic acid decarboxylase (gad) autoantigenic peptides |
WO2012011113A2 (en) | 2010-07-22 | 2012-01-26 | Shai Yarkoni | Regulatory immune cells with enhanced targeted cell death effect |
WO2012014208A2 (en) | 2010-07-27 | 2012-02-02 | Yeda Research And Development Co. Ltd. | Methods and systems for assessing clonality of cell cultures |
WO2012014207A2 (en) | 2010-07-27 | 2012-02-02 | Technion Research & Development Foundation Ltd. | Method for generating induced pluripotent stem cells from keratinocytes derived from plucked hair follicles |
WO2012014205A1 (en) | 2010-07-27 | 2012-02-02 | Technion Research & Development Foundation Ltd. | Isolated mesenchymal progenitor cells and extracellular matrix produced thereby |
WO2012017439A2 (en) | 2010-08-04 | 2012-02-09 | Ramot At Tel-Aviv University Ltd. | Methods of treating autoimmune diseases of the central nervous system (cns) and neurodegenerative diseases |
WO2012025914A1 (en) | 2010-08-22 | 2012-03-01 | Ramot At Tel-Aviv University Ltd. | Induced pluripotent stem cells derived from human pancreatic beta cells |
WO2012025925A1 (en) | 2010-08-24 | 2012-03-01 | Rappaport Family Institute For Research In The Medical Sciences | Methods of improving transplantation using sdf-1alpha |
US10457954B2 (en) | 2010-08-30 | 2019-10-29 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for increasing nitrogen use efficiency, yield, growth rate, vigor, biomass, oil content, and/or abiotic stress tolerance |
WO2012032521A2 (en) | 2010-09-07 | 2012-03-15 | Technion Research & Development Foundation Ltd. | Novel methods and culture media for culturing pluripotent stem cells |
WO2012032510A1 (en) | 2010-09-07 | 2012-03-15 | Yeda Research And Development Co. Ltd. | Primers for amplifying dna and methods of selecting same |
WO2012032519A2 (en) | 2010-09-07 | 2012-03-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of diagnosing parkinson's disease |
WO2012032520A1 (en) | 2010-09-07 | 2012-03-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Readthrough acetylcholinesterase (ache-r) for treating or preventing parkinson's disease |
WO2012032526A2 (en) | 2010-09-08 | 2012-03-15 | Yeda Research And Development Co. Ltd. | Use of anti third party central memory t cells for anti-leukemia/lymphoma treatment |
WO2012032525A2 (en) | 2010-09-08 | 2012-03-15 | Yeda Research And Development Co. Ltd. | An immunosuppressive drug combination for a stable and long term engraftment |
US9095540B2 (en) | 2010-09-09 | 2015-08-04 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
WO2012034067A1 (en) | 2010-09-09 | 2012-03-15 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
WO2012035539A1 (en) | 2010-09-15 | 2012-03-22 | Ramot At Tel-Aviv University Ltd. | Methods of expanding and redifferentiating islet beta cells |
WO2012038956A1 (en) | 2010-09-20 | 2012-03-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of treating neurodegenerative diseases |
EP3075396A1 (en) | 2010-10-17 | 2016-10-05 | Yeda Research and Development Co. Ltd. | Methods and compositions for the treatment of insulin-associated medical conditions |
WO2012052872A2 (en) | 2010-10-17 | 2012-04-26 | Yeda Research And Development Co. Ltd. | Methods and compositions for the treatment of insulin-associated medical conditions |
WO2012052878A1 (en) | 2010-10-19 | 2012-04-26 | Vascular Biogenics Ltd. | Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells |
WO2012056452A2 (en) | 2010-10-27 | 2012-05-03 | Nanocyte (Israel) Ltd. | Pharmaceutical compositions and delivery devices comprising stinging cells or capsules |
WO2012056455A1 (en) | 2010-10-28 | 2012-05-03 | Yeda Research And Development Co. Ltd. | Methods of generating antibodies to metalloenzymes |
WO2012059922A2 (en) | 2010-11-03 | 2012-05-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Transgenic plants with improved saccharification yields and methods of generating same |
WO2012059925A2 (en) | 2010-11-04 | 2012-05-10 | Ben-Gurion University Of The Negev Research And Development Authority | Acyl-coa: diacylglycerol acyltransferase 1-like gene (ptdgat1) and uses thereof |
US9630989B2 (en) | 2010-11-15 | 2017-04-25 | Ramot At Tel-Aviv University Ltd. | Dipeptide analogs for treating conditions associated with amyloid fibril formation |
US9096645B2 (en) | 2010-11-15 | 2015-08-04 | Ramot At Tel-Aviv University Ltd. | Dipeptide analogs for treating conditions associated with amyloid fibril formation |
WO2012066495A2 (en) | 2010-11-17 | 2012-05-24 | Ben Gurion University Of The Negev Research And Development Authority | T-cell therapy to neurodegenerative diseases |
WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
WO2012073238A1 (en) | 2010-12-02 | 2012-06-07 | Technion Research & Development Foundation Ltd. | Methods of generating corneal cells and cell populations comprising same |
EP2463382A1 (en) | 2010-12-07 | 2012-06-13 | Enterologics, Inc. | Method for identifying E. Coli M-17 |
WO2012081029A1 (en) | 2010-12-15 | 2012-06-21 | Kadimastem Ltd. | Insulin producing cells derived from pluripotent stem cells |
US9551006B2 (en) | 2010-12-22 | 2017-01-24 | Evogene Ltd. | Isolated polynucleotides and polypeptides, and methods of using same for improving plant properties |
WO2012090205A2 (en) | 2010-12-28 | 2012-07-05 | Kamedis Ltd. | Plant extracts for the treatment and prevention of infections |
WO2012098537A1 (en) | 2011-01-20 | 2012-07-26 | Protalix Ltd. | Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells |
WO2012104851A1 (en) | 2011-01-31 | 2012-08-09 | Yeda Research And Development Co. Ltd. | Methods of diagnosing disease using overlap extension pcr |
WO2012114339A1 (en) | 2011-02-23 | 2012-08-30 | Rappaport Family Institute For Research In The Medical Sciences | High affinity molecules capable of binding a type a plexin receptor and uses of same |
WO2012113921A1 (en) | 2011-02-25 | 2012-08-30 | Laboratorios Del Dr. Esteve, S.A. | Rapid selection method for hiv gp-120 variants |
EP2492279A1 (en) | 2011-02-25 | 2012-08-29 | Laboratorios Del. Dr. Esteve, S.A. | Rapid immunogen selection method using lentiviral display |
WO2012117406A2 (en) | 2011-03-02 | 2012-09-07 | Futuragene Israel Ltd. | Bacterial resistant transgenic plants |
WO2012117373A1 (en) | 2011-03-03 | 2012-09-07 | Ramot At Tel-Aviv University Ltd. | Genetically modified muscle cells which express neurotrophic factors |
WO2012120500A2 (en) | 2011-03-06 | 2012-09-13 | Merck Serono S.A. | Low fucose cell lines and uses thereof |
WO2012120518A1 (en) | 2011-03-08 | 2012-09-13 | Ramot At Tel-Aviv University Ltd. | Compositions and methods for diagnosing and treating phenylketonuria (pku) |
WO2012123949A1 (en) | 2011-03-17 | 2012-09-20 | Ramot At Tel-Aviv University Ltd. | Bi- and monospecific, asymmetric antibodies and methods of generating the same |
WO2012123938A1 (en) | 2011-03-17 | 2012-09-20 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Quinolone analogs for treating autoimmune diseases |
WO2012127320A1 (en) | 2011-03-22 | 2012-09-27 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
EP3260533A1 (en) | 2011-03-22 | 2017-12-27 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
WO2012127475A1 (en) | 2011-03-24 | 2012-09-27 | Neurim Pharmaceuticals (1991) Ltd. | Neuroprotective peptides |
WO2012131680A2 (en) | 2011-03-28 | 2012-10-04 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating inflammation |
WO2012137202A1 (en) | 2011-04-05 | 2012-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Composition comprising an iron indicator attached to a microparticle and uses of same for quantifying non-transferrin bound iron (ntbi) and cellular labile iron (lci) |
WO2012137207A1 (en) | 2011-04-06 | 2012-10-11 | Ramot At Tel-Aviv University Ltd. | Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same |
US9150644B2 (en) | 2011-04-12 | 2015-10-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II |
US9676846B2 (en) | 2011-04-12 | 2017-06-13 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II |
WO2012140519A2 (en) | 2011-04-15 | 2012-10-18 | Pluristem Ltd. | Methods and systems for harvesting cells |
US10760088B2 (en) | 2011-05-03 | 2020-09-01 | Evogene Ltd. | Isolated polynucleotides and polypeptides and methods of using same for increasing plant yield, biomass, growth rate, vigor, oil content, abiotic stress tolerance of plants and nitrogen use efficiency |
WO2012150600A2 (en) | 2011-05-04 | 2012-11-08 | Ramot At Tel-Aviv University Ltd. | Regulation of amyloid beta molecular composition for the treatment of alzheimer's disease |
US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
WO2012153333A1 (en) | 2011-05-09 | 2012-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Regeneration and repair of mesenchymal tissue using amelogenin |
WO2012153336A2 (en) | 2011-05-12 | 2012-11-15 | Rakuto Bio Technologies Ltd. | Methods and device for lightening skin complexion |
WO2012156976A1 (en) | 2011-05-16 | 2012-11-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of producing artemisinin in non-host plants and vectors for use in same |
EP3263127A1 (en) | 2011-05-23 | 2018-01-03 | Yeda Research and Development Co. Ltd | Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same |
WO2012160526A2 (en) | 2011-05-23 | 2012-11-29 | Ofir Menashe | Formulations of microorganism comprising particles and uses of same |
WO2012164380A2 (en) | 2011-05-31 | 2012-12-06 | Hutchison Biofilm Medical Solutions Limited | Dispersion and detachment of cell aggregates |
EP3527581A2 (en) | 2011-05-31 | 2019-08-21 | Hutchison Biofilm Medical Solutions Limited | Dispersion and detachment of cell aggregates |
WO2012164565A1 (en) | 2011-06-01 | 2012-12-06 | Yeda Research And Development Co. Ltd. | Compositions and methods for downregulating prokaryotic genes |
US10166295B2 (en) | 2011-06-02 | 2019-01-01 | Opko Biologics Ltd. | Pegylated OXM variants |
WO2012172555A1 (en) | 2011-06-14 | 2012-12-20 | Yeda Research And Development Co. Ltd. | Combination therapy to prevent dcis formation and progression to breast cancer |
WO2012176203A1 (en) | 2011-06-23 | 2012-12-27 | Kaiima Bio Agritech Ltd. | Common wheat, plants or parts thereof having partially or fully multiplied genome, hybrids and products thereof and methods of generating and using same |
US9587010B2 (en) | 2011-07-18 | 2017-03-07 | The Institute For Research In Biomedicine | Neutralizing anti-influenza A virus antibodies and uses thereof |
EP3812397A1 (en) | 2011-07-18 | 2021-04-28 | Institute for Research in Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
EP3418300A1 (en) | 2011-07-18 | 2018-12-26 | Institute for Research in Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
US10815294B2 (en) | 2011-07-18 | 2020-10-27 | Institute For Research In Biomedicine | Neutralizing anti-influenza A virus antibodies and uses thereof |
WO2013011347A1 (en) | 2011-07-18 | 2013-01-24 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
WO2013011507A1 (en) | 2011-07-20 | 2013-01-24 | Kaiima Bio Agritech Ltd. | Maize plants having a partially or fully multiplied genome and uses thereof |
EP2550982A1 (en) | 2011-07-27 | 2013-01-30 | Technion Research & Development Foundation Ltd. | Devices for surgical applications |
WO2013018098A2 (en) | 2011-08-02 | 2013-02-07 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
EP3482765A1 (en) | 2011-08-02 | 2019-05-15 | OPKO Biologics Ltd. | Long-acting growth hormone and methods of producing same |
EP3524679A1 (en) | 2011-08-04 | 2019-08-14 | Yeda Research and Development Co., Ltd. | Micro-rna mir-19 and compositions comprising same for the treatment of medical conditions in which low adrenaline or noradrenaline level is therapeutically beneficial |
EP3208338A1 (en) | 2011-08-04 | 2017-08-23 | Yeda Research and Development Co., Ltd. | Micro-rna mir-15 and compositions comprising same for the treatment of corticotropin-releasing hormone- associated medical conditions |
WO2013018060A2 (en) | 2011-08-04 | 2013-02-07 | Yeda Research And Development Co. Ltd. | Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
WO2013021389A2 (en) | 2011-08-09 | 2013-02-14 | Yeda Research And Development Co.Ltd. | Downregulation of mir-7 for promotion of beta cell differentiation and insulin production |
WO2013024481A1 (en) | 2011-08-14 | 2013-02-21 | Kaiima Bio Agritech Ltd. | Durum wheat plants having a partially or fully multiplied genome and uses thereof |
WO2013035070A1 (en) | 2011-09-07 | 2013-03-14 | Yeda Research And Development Co. Ltd. | Olfactory signature and odorant mixture having the same |
WO2013035099A1 (en) | 2011-09-08 | 2013-03-14 | Yeda Research And Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
WO2013035071A1 (en) | 2011-09-08 | 2013-03-14 | Yeda Research And Development Co. Ltd. | Novel risk biomarkers for lung cancer |
US10760086B2 (en) | 2011-09-13 | 2020-09-01 | Monsanto Technology Llc | Methods and compositions for weed control |
US9416363B2 (en) | 2011-09-13 | 2016-08-16 | Monsanto Technology Llc | Methods and compositions for weed control |
US9422558B2 (en) | 2011-09-13 | 2016-08-23 | Monsanto Technology Llc | Methods and compositions for weed control |
US10806146B2 (en) | 2011-09-13 | 2020-10-20 | Monsanto Technology Llc | Methods and compositions for weed control |
US10808249B2 (en) | 2011-09-13 | 2020-10-20 | Monsanto Technology Llc | Methods and compositions for weed control |
US9422557B2 (en) | 2011-09-13 | 2016-08-23 | Monsanto Technology Llc | Methods and compositions for weed control |
US10829828B2 (en) | 2011-09-13 | 2020-11-10 | Monsanto Technology Llc | Methods and compositions for weed control |
WO2013054331A1 (en) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
EP3360899A1 (en) | 2011-10-11 | 2018-08-15 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
US9771431B2 (en) | 2011-10-11 | 2017-09-26 | Ccam Biotherapeutics Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (CEACAM) |
US11891453B2 (en) | 2011-10-11 | 2024-02-06 | Famewave Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (CEACAM) |
WO2013056377A1 (en) | 2011-10-21 | 2013-04-25 | Augurex Life Sciences Corporation | Antigens derived from citrullinated 14-3-3 and uses thereof in the diagnosis of rheumatoid arthritis |
WO2013061328A2 (en) | 2011-10-27 | 2013-05-02 | Yeda Research And Development Co. Ltd. | Method of treating cancer |
WO2013067076A2 (en) | 2011-11-03 | 2013-05-10 | Quark Pharmaceuticals, Inc. | Methods and compositions for neuroprotection |
WO2013070821A1 (en) | 2011-11-08 | 2013-05-16 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the nervous system |
WO2013076729A1 (en) | 2011-11-23 | 2013-05-30 | Danziger Dan Flower Farm | Otomeria plants |
WO2013076730A1 (en) | 2011-11-27 | 2013-05-30 | Yeda Research And Development Co. Ltd. | Methods of regulating angiogenesis and compositions capable of same |
WO2013084190A1 (en) | 2011-12-08 | 2013-06-13 | Yeda Research And Development Co. Ltd. | Mammalian fetal pulmonary cells and therapeutic use of same |
EP3034087A1 (en) | 2011-12-08 | 2016-06-22 | Yeda Research and Development Co. Ltd. | Mammalian fetal pulmonary cells and therapeutic use of same |
WO2013093921A1 (en) | 2011-12-20 | 2013-06-27 | Collplant Ltd. | Collagen coated synthetic polymer fibers |
US10598572B2 (en) | 2011-12-22 | 2020-03-24 | Realbio Technologies, Ltd. | Sequential lateral capillary flow device for analyte determination |
WO2013093920A2 (en) | 2011-12-22 | 2013-06-27 | Yeda Research And Development Co. Ltd. | A combination therapy for a stable and long term engraftment |
US9726581B2 (en) | 2011-12-22 | 2017-08-08 | Realbio Technologies Ltd. | Sequential lateral flow capillary device for analyte determination |
WO2013098820A1 (en) | 2011-12-28 | 2013-07-04 | Kaiima Bio Agritech Ltd. | Cultivated sorghum plant having a partially or fully multiplied genome and uses of same |
WO2013098813A1 (en) | 2012-01-01 | 2013-07-04 | Qbi Enterprises Ltd. | Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents |
WO2013114363A2 (en) | 2012-01-30 | 2013-08-08 | Yeda Research And Development Co.Ltd. | Antimicrobial agents |
WO2013114374A1 (en) | 2012-02-01 | 2013-08-08 | Protalix Ltd. | Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy |
WO2013114371A1 (en) | 2012-02-01 | 2013-08-08 | Protalix Ltd. | Dry powder formulations of dnase i |
WO2013114373A1 (en) | 2012-02-01 | 2013-08-08 | Protalix Ltd. | Inhalable liquid formulations of dnase i |
US10184131B2 (en) | 2012-02-06 | 2019-01-22 | A.B. Seeds Ltd. | Isolated polynucleotides expressing or modulating microRNAs or targets of same, transgenic plants comprising same and uses thereof |
WO2013121426A1 (en) | 2012-02-13 | 2013-08-22 | Gamida-Cell Ltd. | Culturing of mesenchymal stem cells |
WO2013121427A1 (en) | 2012-02-13 | 2013-08-22 | Gamida-Cell Ltd. | Mesenchymal stem cells conditioned medium and methods of generating and using the same |
US10047345B2 (en) | 2012-02-13 | 2018-08-14 | Gamida-Cell Ltd. | Culturing of mesenchymal stem cells with FGF4 and nicotinamide |
EP3791890A1 (en) | 2012-02-14 | 2021-03-17 | OPKO Biologics Ltd. | Long-acting coagulation factors and uses thereof |
WO2013121416A1 (en) | 2012-02-14 | 2013-08-22 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
EP3326642A1 (en) | 2012-02-14 | 2018-05-30 | OPKO Biologics Ltd. | Long-acting coagulation factors and uses thereof |
WO2013121405A1 (en) | 2012-02-19 | 2013-08-22 | Protalix Ltd. | Oral unit dosage forms and uses of same for the treatment of gaucher disease |
EP3401393A1 (en) | 2012-02-22 | 2018-11-14 | Exostem Biotec Ltd | Micrornas for the generation of astrocytes |
WO2013124817A2 (en) | 2012-02-22 | 2013-08-29 | Brainstem Biotec Ltd. | MicroRNAS FOR THE GENERATION OF ASTROCYTES |
WO2013124816A2 (en) | 2012-02-22 | 2013-08-29 | Brainstem Biotec Ltd. | Generation of neural stem cells and motor neurons |
EP3401394A1 (en) | 2012-02-22 | 2018-11-14 | Exostem Biotec Ltd | Generation of neural stem cells |
WO2013128454A1 (en) | 2012-03-01 | 2013-09-06 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization, (A.R.O.), Volcani Center | Male sterile garlic plants, hybrid offspring of same and methods of generating and using same |
EP3483184A1 (en) | 2012-03-07 | 2019-05-15 | Yeda Research and Development Co. Ltd | Compositions for inhibition of quiescinsulfhydryl oxidase (qsox1) and uses of same |
WO2013132495A1 (en) | 2012-03-07 | 2013-09-12 | Yeda Research And Development Co. Ltd. | Compositions for inhibition of quiescin sulfhydryl oxidase (qsox1) and uses of same |
WO2013136335A1 (en) | 2012-03-15 | 2013-09-19 | Yeda Research And Development Co. Ltd. | Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage |
WO2013140247A1 (en) | 2012-03-20 | 2013-09-26 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
WO2013140389A1 (en) | 2012-03-22 | 2013-09-26 | Ramot At Tel-Aviv University Ltd. | Plif multimeric peptides and uses thereof |
US10683363B2 (en) | 2012-03-30 | 2020-06-16 | The United States Of America As Represented By The Department Of Veteran Affairs | Targeting intracellular target-binding determinants with intracellular antibodies |
WO2013153553A2 (en) | 2012-04-13 | 2013-10-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions for controlling varroa mites in bees |
US9925143B2 (en) | 2012-04-18 | 2018-03-27 | Ramot At Tel-Aviv University Ltd. | Lipidated glycosaminoglycan particles for the delivery of nucleic acids |
US9522945B2 (en) | 2012-04-19 | 2016-12-20 | Opko Biologics Ltd. | Long-acting oxyntomodulin variants and methods of producing same |
WO2013160895A1 (en) | 2012-04-24 | 2013-10-31 | Biokine Therapeutics Ltd. | Peptides and use thereof in the treatment of large cell lung cancer |
WO2013162746A1 (en) | 2012-04-26 | 2013-10-31 | University Of Chicago | Staphylococcal coagulase antigens and methods of their use |
EP3805395A1 (en) | 2012-04-26 | 2021-04-14 | University Of Chicago | Staphylococcal coagulase antigens and methods of their use |
WO2013168164A1 (en) | 2012-05-09 | 2013-11-14 | Yeda Research And Development Co. Ltd. | Variants of tace pro-domain as tnf-a inhibitor and their medical use |
US8865158B2 (en) | 2012-05-22 | 2014-10-21 | Ramot At Tel-Aviv University Ltd. | Bacteriophages for reducing toxicity of bacteria |
WO2013174003A1 (en) | 2012-05-24 | 2013-11-28 | Mountgate Group Limited | Compositions and methods related to prevention and treatment of rabies infection |
US10240161B2 (en) | 2012-05-24 | 2019-03-26 | A.B. Seeds Ltd. | Compositions and methods for silencing gene expression |
WO2013175480A1 (en) | 2012-05-24 | 2013-11-28 | A.B. Seeds Ltd. | Compositions and methods for silencing gene expression |
EP3508497A1 (en) | 2012-05-24 | 2019-07-10 | Mountgate Group Limited | Compositions and methods related to prevention and treatment of rabies infection |
US10240162B2 (en) | 2012-05-24 | 2019-03-26 | A.B. Seeds Ltd. | Compositions and methods for silencing gene expression |
US10934555B2 (en) | 2012-05-24 | 2021-03-02 | Monsanto Technology Llc | Compositions and methods for silencing gene expression |
US9290564B2 (en) | 2012-05-24 | 2016-03-22 | Mountgate Group Limited | Compositions and methods related to the prevention and treatment of rabies infection |
WO2013183048A1 (en) | 2012-06-03 | 2013-12-12 | Ben-Gurion University Of The Negev Research And Development Authority | Functionalized titanium binding peptides and implants coated with same |
US9821070B2 (en) | 2012-06-04 | 2017-11-21 | Opko Biologics Ltd. | Pegylated OXM variants |
US10537646B2 (en) | 2012-06-04 | 2020-01-21 | Opko Biologics Ltd. | Pegylated OXM variants |
WO2013183052A1 (en) | 2012-06-04 | 2013-12-12 | Prolor Biotech Inc. | Pegylated oxm variants |
WO2014006621A1 (en) | 2012-07-03 | 2014-01-09 | Nanospun Technologies Ltd. | Methods and devices for adsorption and biodegradation of petroleum |
US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
EP3594331A1 (en) | 2012-07-29 | 2020-01-15 | Yeda Research and Development Co. Ltd. | Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms |
WO2014020599A1 (en) | 2012-07-29 | 2014-02-06 | Yeda Research And Development Co. Ltd. | Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms |
WO2014020608A1 (en) | 2012-07-31 | 2014-02-06 | Yeda Research And Development Co. Ltd. | Methods of diagnosing and treating motor neuron diseases |
WO2014024183A1 (en) | 2012-08-06 | 2014-02-13 | Brainstorm Cell Therapeutics Ltd. | Methods of generating mesenchymal stem cells which secrete neurotrophic factors |
WO2014027082A1 (en) | 2012-08-17 | 2014-02-20 | Laboratorios Del Dr. Esteve, S.A. | Enhanced rapid immunogen selection method for hiv gp120 variants |
EP2698377A1 (en) | 2012-08-17 | 2014-02-19 | Laboratorios Del. Dr. Esteve, S.A. | Enhanced rapid immunogen selection method for HIV gp120 variants |
WO2014033723A1 (en) | 2012-09-03 | 2014-03-06 | A.B. Seeds Ltd. | Method of improving abiotic stress tolerance of plants and plants generated thereby |
WO2014041544A1 (en) | 2012-09-12 | 2014-03-20 | Ramot At Tel-Aviv University Ltd. | Immunoparticles and methods of generating and using same |
WO2014052588A1 (en) | 2012-09-27 | 2014-04-03 | Research Development Foundation | Attenuated chikungunya virus |
WO2014057490A1 (en) | 2012-10-09 | 2014-04-17 | Ramot At Tel-Aviv University Ltd. | Methods and kits for predicting prognosis of cancer using soluble mortalin in blood |
US9822134B2 (en) | 2012-10-22 | 2017-11-21 | Sabag-Rfa Ltd. | System for delivering therapeutic agents into living cells and cells nuclei |
WO2014064682A1 (en) | 2012-10-24 | 2014-05-01 | Yeda Research And Development Co. Ltd. | Combinations of epidermal growth factor receptor targeting antibodies for treating cancer |
EP3584259A1 (en) | 2012-10-24 | 2019-12-25 | Yeda Research and Development Co., Ltd. | Combinations of epidermal growth factor receptor targeting antibodies for treating cancer |
WO2014068553A1 (en) | 2012-10-29 | 2014-05-08 | Yeda Research And Development Co. Ltd. | Aptamers, multimeric aptamers and uses thereof |
US9808534B2 (en) | 2012-11-20 | 2017-11-07 | Opko Biologics Ltd. | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
WO2014083567A2 (en) | 2012-11-29 | 2014-06-05 | Yeda Research And Development Co. Ltd. | Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors |
WO2014106837A2 (en) | 2013-01-01 | 2014-07-10 | A. B. Seeds Ltd. | ISOLATED dsRNA MOLECULES AND METHODS OF USING SAME FOR SILENCING TARGET MOLECULES OF INTEREST |
US10041068B2 (en) | 2013-01-01 | 2018-08-07 | A. B. Seeds Ltd. | Isolated dsRNA molecules and methods of using same for silencing target molecules of interest |
WO2014106838A2 (en) | 2013-01-01 | 2014-07-10 | A.B. Seeds Ltd. | Methods of introducing dsrna to plant seeds for modulating gene expression |
US10683505B2 (en) | 2013-01-01 | 2020-06-16 | Monsanto Technology Llc | Methods of introducing dsRNA to plant seeds for modulating gene expression |
WO2014108850A2 (en) | 2013-01-09 | 2014-07-17 | Yeda Research And Development Co. Ltd. | High throughput transcriptome analysis |
WO2014108854A1 (en) | 2013-01-09 | 2014-07-17 | Fusimab Ltd. | Monospecific anti-hgf and anti-ang2 antibodies and bispecific anti-hgf/anti-ang2 antibodies |
US10815477B2 (en) | 2013-01-17 | 2020-10-27 | Novellusdx Ltd. | Methods and systems for identifying patient specific driver mutations |
EP3431985A1 (en) | 2013-01-17 | 2019-01-23 | Novellusdx Ltd. | Methods and systems for identifying patient specific driver mutations |
US10047356B2 (en) | 2013-01-17 | 2018-08-14 | Novellusdx Ltd. | Methods and systems for identifying patient specific driver mutations |
WO2014111936A1 (en) | 2013-01-17 | 2014-07-24 | Novellusdx Ltd. | Methods and systems for identifying patient specific driver mutations |
WO2014118785A1 (en) | 2013-02-04 | 2014-08-07 | Ramot At Tel-Aviv University Ltd. | Generation of cytotoxic tumor specific cell lines and uses thereof |
WO2014136114A1 (en) | 2013-03-06 | 2014-09-12 | Protalix Ltd. | TNF alpha INHIBITOR POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, CELLS EXPRESSING SAME AND METHODS OF PRODUCING SAME |
WO2014136117A1 (en) | 2013-03-06 | 2014-09-12 | Protalix Ltd. | USE OF PLANT CELLS EXPRESSING A TNFalpha POLYPEPTIDE INHIBITOR IN THERAPY |
WO2014136113A1 (en) | 2013-03-06 | 2014-09-12 | Protalix Ltd. | Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same |
WO2014138696A1 (en) | 2013-03-07 | 2014-09-12 | University Of Maryland, Baltimore | Immunotherapeutic potential of modified lipooligosaccharides/lipid a |
US10609930B2 (en) | 2013-03-13 | 2020-04-07 | Monsanto Technology Llc | Methods and compositions for weed control |
US10612019B2 (en) | 2013-03-13 | 2020-04-07 | Monsanto Technology Llc | Methods and compositions for weed control |
US10568328B2 (en) | 2013-03-15 | 2020-02-25 | Monsanto Technology Llc | Methods and compositions for weed control |
WO2014147622A1 (en) | 2013-03-21 | 2014-09-25 | Collplant Ltd. | Compositions comprising collagen and prp for tissue regeneration |
WO2014155376A1 (en) | 2013-03-24 | 2014-10-02 | Biokine Therapeutics Ltd. | Methods of treating myeloid leukemia |
WO2014174511A1 (en) | 2013-04-21 | 2014-10-30 | Yeda Research And Development Co. Ltd. | Agents for downregulation of the activity and/or amount of bcl-xl and/or bcl-w |
WO2014174470A1 (en) | 2013-04-23 | 2014-10-30 | Yeda Research And Development Co. Ltd. | Isolated naive pluripotent stem cells and methods of generating same |
WO2014174520A1 (en) | 2013-04-25 | 2014-10-30 | Yeda Research And Development Co. Ltd. | Use of inhibitory peptides for the treatment of inflammatory diseases |
WO2014188423A1 (en) | 2013-05-21 | 2014-11-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Treatment of mast cell related pathologies |
WO2014191995A2 (en) | 2013-05-27 | 2014-12-04 | Rakuto Bio Technologies Ltd. | Enzymatic system-containing cosmetic compositions |
EP3626310A1 (en) | 2013-05-27 | 2020-03-25 | Rakuto Bio Technologies Ltd. | Enzymatic system containing cosmetic compositions |
WO2014207744A1 (en) | 2013-06-24 | 2014-12-31 | Ramot At Tel-Aviv University Ltd. | Omentum based scaffold and delivery system |
US9856495B2 (en) | 2013-07-19 | 2018-01-02 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
US9850496B2 (en) | 2013-07-19 | 2017-12-26 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
US9777288B2 (en) | 2013-07-19 | 2017-10-03 | Monsanto Technology Llc | Compositions and methods for controlling leptinotarsa |
US11377667B2 (en) | 2013-07-19 | 2022-07-05 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
US10597676B2 (en) | 2013-07-19 | 2020-03-24 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
WO2015015489A1 (en) | 2013-07-30 | 2015-02-05 | Biolinerx Ltd. | Antibody for treating diabetes and autoimmune diseases |
US9938316B2 (en) | 2013-08-29 | 2018-04-10 | Yeda Research And Development Co. Ltd. | Selective inhibitors of α2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents |
WO2015033343A1 (en) | 2013-09-03 | 2015-03-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for expressing recombinant polypeptides |
WO2015033337A1 (en) | 2013-09-03 | 2015-03-12 | Technion Research & Development Foundation Limited. | A flap for de-novo tissue regeneration |
WO2015033344A1 (en) | 2013-09-05 | 2015-03-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and kits for inhibiting pathogenicity of group a streptococcus (gas) or group g streptococcus (ggs) |
WO2015037009A1 (en) | 2013-09-16 | 2015-03-19 | Plexicure Ltd. | Isolated proteins capable of binding plexin-a4 and methods of producing and using same |
WO2015040609A1 (en) | 2013-09-17 | 2015-03-26 | Yeda Research And Development Co. Ltd. | Erk-derived peptides and uses thereof |
WO2015049677A1 (en) | 2013-10-01 | 2015-04-09 | Kadimastem Ltd. | Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of amyotrophic lateral sclerosis (als) |
US11932682B2 (en) | 2013-10-02 | 2024-03-19 | Medimmune, Llc | Neutralizing anti-influenza A antibodies and uses thereof |
US11186627B2 (en) | 2013-10-02 | 2021-11-30 | Medimmune, Llc | Neutralizing anti-influenza A antibodies and uses thereof |
US10494419B2 (en) | 2013-10-02 | 2019-12-03 | Medimmune, Llc | Neutralizing anti-influenza A antibodies and uses thereof |
WO2015059695A1 (en) | 2013-10-21 | 2015-04-30 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
EP3763733A1 (en) | 2013-10-21 | 2021-01-13 | OPKO Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US11197915B2 (en) | 2013-10-21 | 2021-12-14 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US10767156B2 (en) | 2013-10-24 | 2020-09-08 | Yeda Research And Development Co., Ltd. | Polynucleotides encoding BREX system polypeptides and methods of using same |
WO2015059690A1 (en) | 2013-10-24 | 2015-04-30 | Yeda Research And Development Co. Ltd. | Polynucleotides encoding brex system polypeptides and methods of using s ame |
WO2015063768A1 (en) | 2013-10-31 | 2015-05-07 | Biokine Therapeutics Ltd. | Methods of treating acute myeloid leukemia with a flt3 mutation |
US9540642B2 (en) | 2013-11-04 | 2017-01-10 | The United States Of America, As Represented By The Secretary Of Agriculture | Compositions and methods for controlling arthropod parasite and pest infestations |
US10100306B2 (en) | 2013-11-04 | 2018-10-16 | Monsanto Technology Llc | Compositions and methods for controlling arthropod parasite and pest infestations |
US10927374B2 (en) | 2013-11-04 | 2021-02-23 | Monsanto Technology Llc | Compositions and methods for controlling arthropod parasite and pest infestations |
WO2015079413A2 (en) | 2013-11-28 | 2015-06-04 | Yeda Research And Development Co. Ltd. | Synaptojanin-2 inhibitors and uses thereof |
WO2015079411A1 (en) | 2013-11-28 | 2015-06-04 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Rna polymerase i inhibitors and uses thereof |
WO2015087327A1 (en) | 2013-12-10 | 2015-06-18 | Yeda Research And Development Co. Ltd. | Use of enzymes which catalyze pyruvate synthesis from formate and acetyl-coa and bacteria expressing same |
US10557138B2 (en) | 2013-12-10 | 2020-02-11 | Beeologics, Inc. | Compositions and methods for virus control in Varroa mite and bees |
US10334848B2 (en) | 2014-01-15 | 2019-07-02 | Monsanto Technology Llc | Methods and compositions for weed control using EPSPS polynucleotides |
WO2015114633A1 (en) | 2014-01-30 | 2015-08-06 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. | Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same |
WO2015114638A2 (en) | 2014-02-03 | 2015-08-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of eliminating stem cells |
WO2015118537A2 (en) | 2014-02-05 | 2015-08-13 | Yeda Research And Development Co. Ltd. | Micro-rnas and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
WO2015118538A1 (en) | 2014-02-06 | 2015-08-13 | Yeda Research And Development Co. Ltd. | Anti cd84 antibodies, compositions comprising same and uses thereof |
WO2015118547A1 (en) | 2014-02-10 | 2015-08-13 | Protalix Ltd. | Method of maintaining disease stability in a subject having gaucher's disease |
WO2015121859A1 (en) | 2014-02-11 | 2015-08-20 | Brainstorm Cell Therapeutics Ltd. | Method of qualifying cells |
WO2015132784A1 (en) | 2014-03-03 | 2015-09-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method and device for detection of pseudomonas aeruginosa |
EP2923709A1 (en) | 2014-03-28 | 2015-09-30 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Multi-component-multistage malaria vaccine |
WO2015144874A1 (en) | 2014-03-28 | 2015-10-01 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Multi-component-multistage malaria vaccines |
US10183066B2 (en) | 2014-03-28 | 2019-01-22 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V | Multi-component-multistage malaria vaccines |
US11091770B2 (en) | 2014-04-01 | 2021-08-17 | Monsanto Technology Llc | Compositions and methods for controlling insect pests |
US11433163B2 (en) | 2014-04-10 | 2022-09-06 | Bonus Therapeutics Ltd. | Bone repair compositions |
WO2015159293A2 (en) | 2014-04-14 | 2015-10-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
WO2015159292A2 (en) | 2014-04-14 | 2015-10-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
EP4306659A2 (en) | 2014-04-14 | 2024-01-17 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | A method and kit for determining the tissue or cell origin of dna |
EP3643795A1 (en) | 2014-04-14 | 2020-04-29 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | A method for determining the death of cells or tissue by dna methylation analysis |
EP4026917A1 (en) | 2014-04-14 | 2022-07-13 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | A method and kit for determining the death of cells or tissue or the tissue or cell origin of dna by dna methylation analysis |
WO2015159295A1 (en) | 2014-04-17 | 2015-10-22 | Yeda Research And Development Co. Ltd. | Methods and kits for analyzing dna binding moieties attached to dna |
US11866509B2 (en) | 2014-04-27 | 2024-01-09 | Famewave Ltd. | Humanized antibodies against CEACAM1 |
US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
US10550196B2 (en) | 2014-04-27 | 2020-02-04 | Famewave Ltd. | Humanized antibodies against CEACAM1 |
WO2015166492A2 (en) | 2014-04-28 | 2015-11-05 | Yeda Research And Development Co. Ltd. | Microbiome response to agents |
WO2015170322A2 (en) | 2014-05-04 | 2015-11-12 | Forrest Innovations Ltd. | Compositions and methods of using same for increasing resistance of infected mosquitoes |
WO2015170324A2 (en) | 2014-05-04 | 2015-11-12 | Forrest Innovations Ltd. | Compositions for mosquito control and uses of same |
WO2015170325A2 (en) | 2014-05-04 | 2015-11-12 | Forrest Innovations Ltd. | Compositions and methods for reducing pathogen-induced citrus greening |
WO2015170320A2 (en) | 2014-05-04 | 2015-11-12 | Forrest Innovations Ltd. | Compositions and methods of using same for controlling pathogenically infected mosquitoes |
WO2015170323A2 (en) | 2014-05-04 | 2015-11-12 | Forrest Innovations Ltd. | Compositions and methods of using same for reducing resistance to mosquito larvicides |
US10993990B2 (en) | 2014-05-16 | 2021-05-04 | Baylor Research Institute | Methods and compositions for treating autoimmune and inflammatory conditions |
WO2015177800A2 (en) | 2014-05-22 | 2015-11-26 | Yeda Research And Development Co. Ltd. | Recombinant microorganisms capable of carbon fixation |
WO2015186128A1 (en) | 2014-06-02 | 2015-12-10 | Kadimastem Ltd. | Methods of inducing myelination and maturation of oligodendrocytes |
WO2015186129A1 (en) | 2014-06-02 | 2015-12-10 | Technion Research & Development Foundation Limited. | Compositions and methods of selectively inhibiting irp1 and treating inflammation |
US10988764B2 (en) | 2014-06-23 | 2021-04-27 | Monsanto Technology Llc | Compositions and methods for regulating gene expression via RNA interference |
WO2015198320A1 (en) | 2014-06-24 | 2015-12-30 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
US11807857B2 (en) | 2014-06-25 | 2023-11-07 | Monsanto Technology Llc | Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression |
WO2015198334A2 (en) | 2014-06-25 | 2015-12-30 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Identification of cancer stem cells and use of same for diagnosis and treatment |
US10583084B2 (en) | 2014-06-26 | 2020-03-10 | Ramot At Tel-Aviv University Ltd. | Liposomal formulations for delivery of nucleic acids |
WO2016005985A2 (en) | 2014-07-09 | 2016-01-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method for reprogramming cells |
WO2016009436A1 (en) | 2014-07-15 | 2016-01-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Isolated polypeptides of cd44 and uses thereof |
US10611819B2 (en) | 2014-07-15 | 2020-04-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Isolated polypeptides of CD44 and uses thereof |
US10294292B2 (en) | 2014-07-15 | 2019-05-21 | Medimmune, Llc | Neutralizing anti-influenza B antibodies and uses thereof |
US11174304B2 (en) | 2014-07-15 | 2021-11-16 | Medimmune, Llc | Neutralizing anti-influenza B antibodies and uses thereof |
US11560417B2 (en) | 2014-07-15 | 2023-01-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Isolated polypeptides of CD44 and uses thereof |
US10519221B2 (en) | 2014-07-15 | 2019-12-31 | Medimmune, Llc | Neutralizing anti-influenza B antibodies and uses thereof |
US11787853B2 (en) | 2014-07-15 | 2023-10-17 | Medimmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
US10550439B2 (en) | 2014-07-21 | 2020-02-04 | Novellusdx Ltd. | Methods for determining drug response of patient specific mutations |
US11015229B2 (en) | 2014-07-21 | 2021-05-25 | Novellusdx Ltd. | Methods and systems for determining oncogenic index of patient specific mutations |
US11124792B2 (en) | 2014-07-29 | 2021-09-21 | Monsanto Technology Llc | Compositions and methods for controlling insect pests |
US10378012B2 (en) | 2014-07-29 | 2019-08-13 | Monsanto Technology Llc | Compositions and methods for controlling insect pests |
WO2016016894A1 (en) | 2014-07-30 | 2016-02-04 | Yeda Research And Development Co. Ltd. | Media for culturing pluripotent stem cells |
WO2016024278A1 (en) | 2014-08-14 | 2016-02-18 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
EP3699930A2 (en) | 2014-08-14 | 2020-08-26 | MeMed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
WO2016030899A1 (en) | 2014-08-28 | 2016-03-03 | Yeda Research And Development Co. Ltd. | Methods of treating amyotrophic lateral scleroses |
WO2016038609A1 (en) | 2014-09-08 | 2016-03-17 | Yeda Research And Development Co. Ltd. | Anti-her3 antibodies and uses of same |
US10213501B2 (en) | 2014-09-08 | 2019-02-26 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Three-component-multistage malaria vaccine |
EP2992895A1 (en) | 2014-09-08 | 2016-03-09 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Three-component-multistage malaria vaccine |
WO2016038610A1 (en) | 2014-09-08 | 2016-03-17 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating cancer resistant to a tyrosine kinase inhibitor (tki) |
WO2016038616A1 (en) | 2014-09-14 | 2016-03-17 | Yeda Research And Development Co. Ltd. | Nmda receptor antagonists for treating gaucher disease |
WO2016042561A2 (en) | 2014-09-21 | 2016-03-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Downregulating mir-132 for the treatment of lipid related disorders |
WO2016055950A1 (en) | 2014-10-08 | 2016-04-14 | Novartis Ag | Combination of human cytomegalovirus neutralizing antibodies |
EP3739062A1 (en) | 2014-10-20 | 2020-11-18 | Gen-Probe Incorporated | Red blood cell lysis solution |
DE102015220401A1 (en) | 2014-10-20 | 2016-05-19 | Gen-Probe Incorporated | Erythrocyte lysis solution |
WO2016064887A1 (en) | 2014-10-20 | 2016-04-28 | Gen-Probe Incorporated | Red blood cell lysis solution |
US11624052B2 (en) | 2014-11-13 | 2023-04-11 | Enzootic Holdings Ltd. | Functional sex-reversal of decapod crustacean females |
WO2016075697A1 (en) | 2014-11-13 | 2016-05-19 | Enzootic Holdings Ltd. | Functional sex-reversal of decapod crustacean females |
WO2016075546A2 (en) | 2014-11-14 | 2016-05-19 | Antonio Lanzavecchia | Antibodies that neutralize ebola virus and uses thereof |
WO2016079736A2 (en) | 2014-11-17 | 2016-05-26 | Yeda Research And Development Co. Ltd. | Methods of treating diseases related to mitochondrial function |
WO2016079731A2 (en) | 2014-11-17 | 2016-05-26 | Yeda Research And Development Co. Ltd. | Method of analyzing microbiome |
EP3831404A1 (en) | 2014-11-18 | 2021-06-09 | Humabs Biomed S.A. | Antibodies that potently neutralize rabies virus and other lyssaviruses and uses thereof |
US11697819B2 (en) | 2014-11-20 | 2023-07-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells |
WO2016079739A2 (en) | 2014-11-20 | 2016-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for producing polypeptides with a modified glycosylation pattern in plant cells |
WO2016084088A1 (en) | 2014-11-26 | 2016-06-02 | Ramot At Tel-Aviv University Ltd. | Targeted elimination of bacterial genes |
WO2016084084A1 (en) | 2014-11-27 | 2016-06-02 | Danziger Innovations Ltd. | Nucleic acid constructs for genome editing |
WO2016092555A2 (en) | 2014-12-11 | 2016-06-16 | Yeda Research And Development Co. Ltd. | Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage |
WO2016103269A1 (en) | 2014-12-23 | 2016-06-30 | Ramot At Tel-Aviv University Ltd. | Populations of neural progenitor cells and methods of producing and using same |
WO2016108240A1 (en) | 2014-12-30 | 2016-07-07 | Cell Cure Neurosciences Ltd. | Assessing retinal pigment epithelial cell populations |
US11891622B2 (en) | 2014-12-30 | 2024-02-06 | Cell Cure Neurosciences Ltd. | RPE cell populations and methods of generating same |
EP3916085A1 (en) | 2014-12-30 | 2021-12-01 | Cell Cure Neurosciences Ltd. | Assessing retinal pigment epithelial cell populations |
EP3674397A1 (en) | 2014-12-30 | 2020-07-01 | Cell Cure Neurosciences Ltd. | Rpe cell populations and methods of generating same |
WO2016108239A1 (en) | 2014-12-30 | 2016-07-07 | Cell Cure Neurosciences Ltd. | Rpe cell populations and methods of generating same |
WO2016108219A1 (en) | 2014-12-30 | 2016-07-07 | Cell Cure Neurosciences Ltd. | Methods of treating retinal diseases |
WO2016108244A1 (en) | 2015-01-04 | 2016-07-07 | Protalix Ltd. | Modified dnase and uses thereof |
WO2016116935A1 (en) | 2015-01-21 | 2016-07-28 | Yeda Research And Development Co. Ltd. | Use of rasa2 as a prognostic and therapeutic marker for melanoma |
US10968449B2 (en) | 2015-01-22 | 2021-04-06 | Monsanto Technology Llc | Compositions and methods for controlling Leptinotarsa |
WO2016135732A1 (en) | 2015-02-26 | 2016-09-01 | Yeda Research And Development Co. Ltd. | Method of promoting hair growth |
WO2016142948A1 (en) | 2015-03-11 | 2016-09-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Decoy oligonucleotides for the treatment of diseases |
WO2016147194A1 (en) | 2015-03-19 | 2016-09-22 | Yeda Research And Development Co. Ltd. | Anti amphiregulin antibodies, compositions comprising same and uses thereof |
EP4218771A1 (en) | 2015-03-27 | 2023-08-02 | Yeda Research and Development Co. Ltd | Methods of treating motor neuron diseases |
WO2016160618A2 (en) | 2015-03-27 | 2016-10-06 | University Of Southern California | Car t-cell therapy directed to lhr for the treatment of solid tumors |
WO2016157190A1 (en) | 2015-03-31 | 2016-10-06 | Yeda Research And Development Co. Ltd. | Glutamate oxaloacetate transaminase 1 (got1), preparations and methods of generating same and uses thereof |
WO2016157192A1 (en) | 2015-04-01 | 2016-10-06 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Erodium crassifolium l'her plant extracts and uses thereof |
WO2016162870A1 (en) | 2015-04-07 | 2016-10-13 | Ilana Nathan | Compositions for treating and/or preventing cell or tissue necrosis specifically targeting cathepsin c and/or cela1 and/or cela3a and/or structurally related enzymes thereto |
EP4005569A2 (en) | 2015-04-07 | 2022-06-01 | ELA Pharma Ltd | Compositions for treating and/or preventing cell or tissue necrosis specifically targeting cathepsin c and/or cela1 and/or cela3a and/or structurally related enzymes thereto |
US10577412B2 (en) | 2015-04-12 | 2020-03-03 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. | Anti-plasmodium parasite antibodies |
WO2016174674A1 (en) | 2015-04-27 | 2016-11-03 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Egr1 targeting molecules for the treatment of inflammatory and hyperproliferative conditions |
WO2016174673A1 (en) | 2015-04-29 | 2016-11-03 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Anti-phytopathogenic compositions |
US10674732B2 (en) | 2015-04-29 | 2020-06-09 | The State Of Israel, Ministry Of Agriculture & Rural Development Agricultural Research Organization | Anti-phytopathogenic compositions |
WO2016174652A1 (en) | 2015-04-30 | 2016-11-03 | Technion Research & Development Foundation Limited | Chimeric antigen receptors and methods of their use |
WO2016178207A1 (en) | 2015-05-04 | 2016-11-10 | Ramot At Tel-Aviv University Ltd. | Methods and kits for fragmenting dna |
WO2016181393A1 (en) | 2015-05-11 | 2016-11-17 | Yeda Research And Development Co. Ltd. | Citrin inhibitors for the treatment of cancer |
WO2016185471A1 (en) | 2015-05-17 | 2016-11-24 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Compositions and methods for treating cancer |
WO2016185457A1 (en) | 2015-05-19 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Methods of promoting lymphangiogenesis |
WO2016185481A2 (en) | 2015-05-20 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Method of targeting senescent cells |
WO2016185469A1 (en) | 2015-05-21 | 2016-11-24 | Yeda Research And Development Co. Ltd. | Bacterial populations for promoting health |
WO2016193969A2 (en) | 2015-05-29 | 2016-12-08 | Opko Biologics Ltd. | Pegylated oxyntomodulin variants |
US11524993B2 (en) | 2015-06-01 | 2022-12-13 | Medimmune, Llc | Neutralizing anti-influenza binding molecules and uses thereof |
US11926657B2 (en) | 2015-06-01 | 2024-03-12 | Medimmune, Llc | Neutralizing anti-influenza binding molecules and uses thereof |
US10442854B2 (en) | 2015-06-01 | 2019-10-15 | Medimmune, Llc | Neutralizing anti-influenza binding molecules and uses thereof |
US10882897B2 (en) | 2015-06-01 | 2021-01-05 | Medimmune, Llc | Neutralizing anti-influenza binding molecules and uses thereof |
US10883103B2 (en) | 2015-06-02 | 2021-01-05 | Monsanto Technology Llc | Compositions and methods for delivery of a polynucleotide into a plant |
US10655136B2 (en) | 2015-06-03 | 2020-05-19 | Monsanto Technology Llc | Methods and compositions for introducing nucleic acids into plants |
WO2016197064A1 (en) | 2015-06-04 | 2016-12-08 | Epstein Alan L | Lym-1 and lym-2 targeted car cell immunotherapy |
WO2016199140A1 (en) | 2015-06-08 | 2016-12-15 | Adicet Bio Inc. | T cell receptor like antibodies having fine specificity |
EP4039270A1 (en) | 2015-06-08 | 2022-08-10 | Adicet Bio Inc. | Affinity entities comprising a tcr-like antibody binding domain with high affinity and fine specificity and uses of same |
WO2016199141A2 (en) | 2015-06-08 | 2016-12-15 | Adicet Bio Inc. | Affinity entities comprising a tcr-like antibody binding domain with high affinity and fine specificity and uses of same |
EP4026563A1 (en) | 2015-06-18 | 2022-07-13 | Yeda Research and Development Co. Ltd | Conditioning protocols and use of same for tissue regeneration |
WO2016203477A1 (en) | 2015-06-18 | 2016-12-22 | Yeda Research And Development Co. Ltd. | Conditioning protocols and use of same for tissue regeneration |
WO2016203476A1 (en) | 2015-06-18 | 2016-12-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and compositions for diagnosing and treating urothelial cancer |
EP3988113A1 (en) | 2015-06-19 | 2022-04-27 | OPKO Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
WO2016203482A2 (en) | 2015-06-19 | 2016-12-22 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US10960058B2 (en) | 2015-06-19 | 2021-03-30 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
WO2016207402A1 (en) | 2015-06-26 | 2016-12-29 | Institute For Research In Biomedicine | Proteins comprising a mutated lair-1 fragment and uses thereof |
EP3943098A2 (en) | 2015-07-16 | 2022-01-26 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
EP3744340A2 (en) | 2015-07-16 | 2020-12-02 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
WO2017009853A1 (en) | 2015-07-16 | 2017-01-19 | Yeda Research And Development Co. Ltd. | Genetically modified anti-third party central memory t cells and use of same in immunotherapy |
WO2017009852A1 (en) | 2015-07-16 | 2017-01-19 | Yeda Research And Development Co. Ltd. | Use of anti third party central memory t cells |
WO2017009842A2 (en) | 2015-07-16 | 2017-01-19 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
US11077128B2 (en) | 2015-07-19 | 2021-08-03 | Yeda Research And Development Co. Ltd. | Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure |
US10668094B2 (en) | 2015-07-19 | 2020-06-02 | Yeda Research And Development Co. Ltd. | Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure |
WO2017013661A1 (en) | 2015-07-22 | 2017-01-26 | Phytopharma International Ltd. | Bee-ingestible compositions, methods of using same for producing honey and honey produced thereby |
EP3862425A1 (en) | 2015-07-29 | 2021-08-11 | Hadasit Medical Research Services and Development Ltd. | Large scale production of retinal pigment epithelial cells |
WO2017017686A1 (en) | 2015-07-29 | 2017-02-02 | Hadasit Medical Research Services And Development Ltd. | Large scale production of retinal pigment epithelial cells |
US11230696B2 (en) | 2015-07-29 | 2022-01-25 | Hadasit Medical Research Services And Development Ltd. | Large scale production of retinal pigment epithelial cells |
WO2017021963A1 (en) | 2015-08-03 | 2017-02-09 | Biokine Therapeutics Ltd. | Cxcr4 binding agents for treatment of diseases |
WO2017021961A1 (en) | 2015-08-04 | 2017-02-09 | Yeda Research And Development Co. Ltd. | Methods of screening for riboswitches and attenuators |
US11066642B2 (en) | 2015-08-05 | 2021-07-20 | Cell Cure Neurosciences Ltd | Preparation of retinal pigment epithelium cells |
WO2017021973A1 (en) | 2015-08-05 | 2017-02-09 | Cell Cure Neurosciences Ltd. | Preparation of retinal pigment epithelium cells |
EP4155391A1 (en) | 2015-08-05 | 2023-03-29 | Cell Cure Neurosciences Ltd. | Preparation of retinal pigment epithelium cells |
US11090337B2 (en) | 2015-08-05 | 2021-08-17 | Cell Cure Neurosciences Ltd | Preparation of photoreceptors for the treatment of retinal diseases |
WO2017021972A1 (en) | 2015-08-05 | 2017-02-09 | Cell Cure Neurosciences Ltd. | Preparation of photoreceptors for the treatment of retinal diseases |
WO2017025963A1 (en) | 2015-08-10 | 2017-02-16 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Methods and pharmaceutical compositions for improving wound healing using cd24 |
WO2017025967A1 (en) | 2015-08-13 | 2017-02-16 | Forrest Innovations Ltd. | Formulations and compositions for delivery of nucleic acids to plant cells |
WO2017033188A1 (en) | 2015-08-24 | 2017-03-02 | Yeda Research And Development Co. Ltd. | Algal oil and biofuel and methods of producing same |
US10765706B2 (en) | 2015-09-03 | 2020-09-08 | University Of South Florida | Method of stem cell delivery into the brain during chronic disease using blood brain barrier permeabilizers |
WO2017042814A1 (en) | 2015-09-10 | 2017-03-16 | Yeda Research And Development Co. Ltd. | Use of perforin positive immature dendritic cells in disease treatment |
EP3753949A1 (en) | 2015-10-07 | 2020-12-23 | Humabs Biomed SA | Antibodies that potently neutralize hepatitis b virus and uses thereof |
US11390664B2 (en) | 2015-10-07 | 2022-07-19 | Humabs Biomed Sa | Antibodies that potently neutralize hepatitis B virus and uses thereof |
US10683344B2 (en) | 2015-10-07 | 2020-06-16 | Humabs Biomed Sa | Antibodies that potently neutralize hepatitis B virus and uses thereof |
WO2017072757A1 (en) | 2015-10-25 | 2017-05-04 | Yeda Research And Development Co. Ltd. | Antibodies targeting quiescin sulfhydryl oxidase (qsox1) and uses of same |
WO2017072763A1 (en) | 2015-10-26 | 2017-05-04 | Cell Cure Neurosciences Ltd. | Preparation of retinal pigment epithelium cells |
WO2017072773A1 (en) | 2015-10-27 | 2017-05-04 | Ilana Nathan | Compositions comprising cannabidiol and second therapeutic agents for the treatment of cancer |
WO2017072772A1 (en) | 2015-10-29 | 2017-05-04 | Yeda Research And Development Co. Ltd. | A method of inducing cardiomyocytes proliferation and treating heart diseases |
WO2017077539A1 (en) | 2015-11-03 | 2017-05-11 | Ariel-University Research And Development Company Ltd. | Compositions for regeneration and repair of neural tissue |
WO2017081689A1 (en) | 2015-11-11 | 2017-05-18 | Ramot At Tel-Aviv University Ltd. | Methods of detecting 5-hydroxymethylcytosine and diagnosing of cancer |
EP4231015A1 (en) | 2015-11-30 | 2023-08-23 | Kadimastem Ltd. | Methods for differentiating and purifying pancreatic endocrine cells |
WO2017094001A1 (en) | 2015-11-30 | 2017-06-08 | Kadimastem Ltd | Methods for differentiating and purifying pancreatic endocrine cells |
EP3176183A1 (en) | 2015-12-02 | 2017-06-07 | Yeda Research and Development Co. Ltd | Compositions and methods for treating cancer not resistant to a tyrosine kinase inhibitor (tki) |
EP4059507A1 (en) | 2015-12-16 | 2022-09-21 | Ramot at Tel-Aviv University Ltd. | Particles comprising decellularized omentum |
US10561706B2 (en) | 2015-12-28 | 2020-02-18 | B. G. Negev Technologies And Applications | Isolated polypeptide and compositions comprising same |
WO2017118985A1 (en) | 2016-01-06 | 2017-07-13 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating malignant, autoimmune and inflammatory diseases |
WO2017122203A1 (en) | 2016-01-11 | 2017-07-20 | Technion Research & Development Foundation Limited | Methods of determining prognosis of sepsis and treating same |
US11547756B2 (en) | 2016-01-13 | 2023-01-10 | Medimmune, Llc | Method of treating influenza A |
WO2017125931A1 (en) | 2016-01-21 | 2017-07-27 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Parthenocarpic plants and methods of producing same |
US10964443B2 (en) | 2016-01-28 | 2021-03-30 | Sp Nano Ltd. | Conductive yarn |
US10954313B2 (en) | 2016-01-28 | 2021-03-23 | Sp Nano Ltd. | Composition comprising SP1 and carbon based nanoparticles and uses thereof |
WO2017130205A1 (en) | 2016-01-31 | 2017-08-03 | Hadasit Medical Research Services And Development Ltd. | Autosomal-identical pluripotent stem cell populations having non-identical sex chromosomal composition and uses thereof |
WO2017134671A1 (en) | 2016-02-04 | 2017-08-10 | Yeda Research And Development Co. Ltd. | Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant p53 |
US11230578B2 (en) | 2016-02-04 | 2022-01-25 | Yeda Research And Development Co. Ltd. | Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant P53 |
EP3708675A1 (en) | 2016-02-14 | 2020-09-16 | Yeda Research and Development Co. Ltd. | Microbiome-based diagnosis, prediction and treatment of relapsing obesity |
WO2017138007A1 (en) | 2016-02-14 | 2017-08-17 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Microbiome-based diagnosis, prediction and treatment of relapsing obesity |
WO2017138008A2 (en) | 2016-02-14 | 2017-08-17 | Yeda Research And Development Co. Ltd. | Methods of modulating protein exocytosis and uses of same in therapy |
WO2017141253A1 (en) | 2016-02-16 | 2017-08-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Non-protein phenylalanine analogues for inhibiting cyanobacteria and plant growth |
WO2017145162A1 (en) | 2016-02-23 | 2017-08-31 | Chaya Brodie | Generation of cancer stem cells and use thereof |
US10906987B2 (en) | 2016-03-01 | 2021-02-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies specific to human poliovirus receptor (PVR) |
WO2017149547A1 (en) | 2016-03-03 | 2017-09-08 | Memed Diagnostics Ltd. | Analyzing rna for diagnosing infection type |
EP3907292A1 (en) | 2016-03-03 | 2021-11-10 | Memed Diagnostics Ltd. | Analyzing rna for diagnosing infection type |
WO2017153982A1 (en) | 2016-03-06 | 2017-09-14 | Yeda Research And Development Co. Ltd. | Method for modulating myelination |
WO2017158610A1 (en) | 2016-03-17 | 2017-09-21 | Yeda Research And Development Co. Ltd. | Methods of isolating barrel-like proteases and identifying peptides processed thereby |
US10421785B2 (en) | 2016-04-11 | 2019-09-24 | Bar-Ilan University | Delta receptor agonist peptides and use thereof |
DE202017007130U1 (en) | 2016-04-27 | 2019-08-29 | Gen-Probe Inc. | Lysis reagent for blood cells |
EP3736332A1 (en) | 2016-04-27 | 2020-11-11 | Gen-Probe Incorporated | Blood cell lysis reagent |
WO2017189746A1 (en) | 2016-04-27 | 2017-11-02 | Gen-Probe Incorporated | Blood cell lysis reagent |
DE202017007129U1 (en) | 2016-04-27 | 2019-08-29 | Gen-Probe Incorporated | Lysis reagent for blood cells |
WO2017203520A1 (en) | 2016-05-22 | 2017-11-30 | Yeda Research And Development Co. Ltd. | Methods of using pulmonary cells for transplantation and induction of tolerance |
WO2017203532A1 (en) | 2016-05-25 | 2017-11-30 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Agents for use treating drug resistant tumors and triple negative breast cancer |
WO2017208247A1 (en) | 2016-06-02 | 2017-12-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Assay for the removal of methyl-cytosine residues from dna |
WO2017212476A1 (en) | 2016-06-05 | 2017-12-14 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Novel molecules for the treatment of inflammation |
WO2017212494A1 (en) | 2016-06-09 | 2017-12-14 | Opko Biologics Ltd. | Long-acting oxyntomodulin formulation and methods of producing and administering same |
US11859232B2 (en) | 2016-06-19 | 2024-01-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Screening for chemotherapy resistance in human haploid cells |
WO2017221225A1 (en) | 2016-06-19 | 2017-12-28 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Screening for chemotherapy resistance in human haploid cells |
WO2018002924A1 (en) | 2016-06-27 | 2018-01-04 | Yeda Research And Development Co. Ltd. | Veto cells generated from memory t cells |
EP4184167A1 (en) | 2016-07-10 | 2023-05-24 | MeMed Diagnostics Ltd. | Early diagnosis of infections |
EP4141448A1 (en) | 2016-07-10 | 2023-03-01 | MeMed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
WO2018011796A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Early diagnosis of infections |
WO2018011795A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Protein signatures for distinguishing between bacterial and viral infections |
WO2018011806A1 (en) | 2016-07-11 | 2018-01-18 | Yeda Research And Development Co. Ltd. | Combination therapy to increase endogenous nitric oxide (no) synthesis |
EP4303228A2 (en) | 2016-07-11 | 2024-01-10 | OPKO Biologics Ltd. | Long-acting coagulation factor vii and methods of producing same |
WO2018011799A1 (en) | 2016-07-11 | 2018-01-18 | Opko Biologics Ltd. | Long-acting coagulation factor vii and methods of producing same |
WO2018011805A2 (en) | 2016-07-11 | 2018-01-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Systems and methods for growing cells in vitro |
WO2018011804A1 (en) | 2016-07-11 | 2018-01-18 | Bonus Therapeutics Ltd. | Cell compositions for tissue regeneration |
EP4342911A1 (en) | 2016-07-13 | 2024-03-27 | Humabs Biomed SA | Novel antibodies specifically binding to zika virus epitopes and uses thereof |
US11912757B2 (en) | 2016-07-13 | 2024-02-27 | Humabs Biomed Sa | Antibodies specifically binding to Zika virus epitopes and uses thereof |
WO2018011283A1 (en) | 2016-07-13 | 2018-01-18 | Humabs Biomed Sa | Novel antibodies specifically binding to zika virus epitopes and uses thereof |
US11117954B2 (en) | 2016-07-13 | 2021-09-14 | Humabs Biomed Sa | Antibodies specifically binding to zika virus epitopes and uses thereof |
WO2018020489A1 (en) | 2016-07-24 | 2018-02-01 | Yeda Research And Development Co. Ltd. | Methods and kits for analyzing dna binding moieties attached to dna |
WO2018029682A1 (en) | 2016-08-08 | 2018-02-15 | Ramot At Tel-Aviv University Ltd. | Bacterial systems for analyzing ubiquitylated polypeptides |
WO2018029690A1 (en) | 2016-08-10 | 2018-02-15 | Memed Diagnostics Ltd. | System and method for analysis of biological data |
EP4033248A1 (en) | 2016-08-10 | 2022-07-27 | MeMed Diagnostics Ltd. | System and method for analysis of biological data |
WO2018033911A1 (en) | 2016-08-14 | 2018-02-22 | Ramot At Tel-Aviv University Ltd. | Mesenchymal cell-derived exosomes to treat neurological disorders |
US11129852B2 (en) | 2016-08-14 | 2021-09-28 | Ramot At Tel Aviv University Ltd. | Mesenchymal cell-derived exosomes to treat neurological disorders |
WO2018033929A1 (en) | 2016-08-18 | 2018-02-22 | Yeda Research And Development Co. Ltd. | Diagnostic and therapeutic uses of exosomes |
WO2018037416A1 (en) | 2016-08-25 | 2018-03-01 | Yeda Research And Development Co. Ltd. | Methods and compositions for treating autoimmune diseases |
WO2018047154A1 (en) | 2016-09-07 | 2018-03-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Anti-nkp46 antibodies and therapeutic use of same |
US10716864B2 (en) | 2016-09-07 | 2020-07-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Anti-NKP46 antibodies, toxin conjugates, and therapeutic use of same |
WO2018051347A1 (en) | 2016-09-14 | 2018-03-22 | Yeda Research And Development Co. Ltd. | Crisp-seq, an integrated method for massively parallel single cell rna-seq and crispr pooled screens |
WO2018060998A1 (en) | 2016-09-29 | 2018-04-05 | Memed Diagnostics Ltd. | Methods of prognosis and treatment |
WO2018069885A1 (en) | 2016-10-13 | 2018-04-19 | Technion Research & Development Foundation Limited | Use of caspase-3 inhibitors and caspase-3 activators in the manufacture of medicament for treating cancer and wound healing |
WO2018073823A2 (en) | 2016-10-18 | 2018-04-26 | Yeda Research And Development Co. Ltd. | Treatment of a circadian rhythm disorder |
US11319348B2 (en) | 2016-10-28 | 2022-05-03 | The Regents Of The University Of California | Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers |
US10662226B2 (en) | 2016-10-28 | 2020-05-26 | The Regents of the University of Caiifomia | Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers |
WO2018087759A1 (en) | 2016-11-10 | 2018-05-17 | Yeda Research And Development Co. Ltd. | Phosphotriesterases for treating or preventing organophosphate exposure associated damage |
WO2018096547A1 (en) | 2016-11-28 | 2018-05-31 | Yeda Research And Development Co. Ltd. | Isolated polynucleotides and polypeptides and methods of using same for expressing an expression product of interest |
WO2018100574A1 (en) | 2016-11-30 | 2018-06-07 | Yeda Research And Development Co. Ltd. | Methods of treating liver toxicity and disorders |
WO2018100511A1 (en) | 2016-12-01 | 2018-06-07 | Ramot At Tel-Aviv University Ltd. | Combined treatment for nerve injuries |
WO2018134824A1 (en) | 2017-01-18 | 2018-07-26 | Yeda Research And Development Co. Ltd. | Genetically modified veto cells and use of same in immunotherapy |
WO2018142416A1 (en) | 2017-02-06 | 2018-08-09 | Yeda Research And Development Co. Ltd. | Isolated cells genetically modified to express a disarm system having an anti-phage activity and methods of producing same |
WO2018158775A1 (en) | 2017-03-02 | 2018-09-07 | Yeda Research And Development Co. Ltd. | Methods of culturing t cells and uses of same |
WO2018167780A1 (en) | 2017-03-12 | 2018-09-20 | Yeda Research And Development Co. Ltd. | Methods of prognosing and treating cancer |
WO2018167778A1 (en) | 2017-03-12 | 2018-09-20 | Yeda Research And Development Co. Ltd. | Methods of diagnosing and prognosing cancer |
WO2018170494A1 (en) | 2017-03-16 | 2018-09-20 | Bio Time, Inc. | Methods for measuring therapeutic effects of retinal disease therapies |
WO2018185760A1 (en) | 2017-04-05 | 2018-10-11 | Yeda Research And Development Co. Ltd. | Ex-vivo culture system and methods of using same |
EP4317971A2 (en) | 2017-04-05 | 2024-02-07 | Yeda Research and Development Co. Ltd | Ex-vivo culture system and methods of using same |
WO2018193063A2 (en) | 2017-04-19 | 2018-10-25 | Institute For Research In Biomedicine | Novel malaria vaccines and antibodies binding to plasmodium sporozoites |
WO2018207178A1 (en) | 2017-05-07 | 2018-11-15 | Yeda Research And Development Co. Ltd. | Methods of treating psychiatric stress disorders |
EP3821888A1 (en) | 2017-05-07 | 2021-05-19 | Yeda Research and Development Co. Ltd | Lxr agonists for treating psychiatric stress disorders |
WO2018207184A2 (en) | 2017-05-10 | 2018-11-15 | Ariel Scientific Innovations Ltd. | Methods of purifying antibodies |
WO2018216006A1 (en) | 2017-05-21 | 2018-11-29 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Combination of markers for diagnosing cancer |
WO2018216011A1 (en) | 2017-05-23 | 2018-11-29 | Technion Research & Development Foundation Limited | Agents which inhibit gads dimerization and methods of use thereof |
WO2018220582A1 (en) | 2017-05-31 | 2018-12-06 | Tropic Biosciences UK Limited | Methods of selecting cells comprising genome editing events |
WO2018220581A1 (en) | 2017-05-31 | 2018-12-06 | Tropic Biosciences UK Limited | Compositions and methods for increasing shelf-life of banana |
WO2018220579A1 (en) | 2017-05-31 | 2018-12-06 | Tropic Biosciences UK Limited | Compositions and methods for increasing extractability of solids from coffee beans |
WO2018229764A1 (en) | 2017-06-13 | 2018-12-20 | Yeda Research And Development Co. Ltd. | Treatment of advanced or progressive multiple sclerosis |
WO2019012543A1 (en) | 2017-07-13 | 2019-01-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Dna targets as tissue-specific methylation markers |
WO2019012544A1 (en) | 2017-07-13 | 2019-01-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Dual-probe digital droplet pcr strategy for specific detection of tissue-specific circulating dna molecules |
WO2019012542A1 (en) | 2017-07-13 | 2019-01-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Detecting tissue-specific dna |
WO2019021284A1 (en) | 2017-07-24 | 2019-01-31 | Yeda Research And Development Co. Ltd. | Combination therapy for the treatment of cancer |
WO2019035128A1 (en) | 2017-08-14 | 2019-02-21 | Yeda Research And Development Co. Ltd. | Immunotherapy against transferrin receptor 1 (tfr1)-tropic arenaviruses |
WO2019038771A1 (en) | 2017-08-23 | 2019-02-28 | Technion Research & Development Foundation Limited | Compositions and methods for improving alcohol tolerance in yeast |
WO2019043166A1 (en) | 2017-08-31 | 2019-03-07 | Humabs Biomed Sa | Multispecific antibodies specifically binding to zika virus epitopes and uses thereof |
WO2019042555A1 (en) | 2017-08-31 | 2019-03-07 | Humabs Biomed Sa | Multispecific antibodies specifically binding to zika virus epitopes and uses thereof |
US11926658B2 (en) | 2017-08-31 | 2024-03-12 | Humabs Biomed Sa | Multispecific antibodies specifically binding to Zika virus epitopes |
EP4170029A2 (en) | 2017-09-19 | 2023-04-26 | Tropic Biosciences UK Limited | Modifying the specifity of plant non-coding rna molecules for silencing gene expression |
US11555199B2 (en) | 2017-09-19 | 2023-01-17 | Tropic Biosciences UK Limited | Modifying the specificity of plant non-coding RNA molecules for silencing gene expression |
WO2019094595A2 (en) | 2017-11-09 | 2019-05-16 | Pinteon Therapeutics Inc. | Methods and compositions for the generation and use of humanized conformation-specific phosphorylated tau antibodies |
WO2019097514A1 (en) | 2017-11-14 | 2019-05-23 | Yeda Research And Development Co. Ltd. | Hematopoietic stem cells with improved properties |
WO2019106667A1 (en) | 2017-11-29 | 2019-06-06 | Weedout Ltd. | Compositions, kits and methods for controlling weed of the amaranthus genus |
WO2019106671A1 (en) | 2017-11-29 | 2019-06-06 | Ramot At Tel-Aviv University Ltd. | Methods of preventing or treating neurogenic shock |
WO2019106680A1 (en) | 2017-12-03 | 2019-06-06 | Yeda Research And Development Co. Ltd. | Treatment of an ischemic heart disease |
WO2019116376A1 (en) | 2017-12-17 | 2019-06-20 | Yeda Research And Development Co. Ltd. | Cop9 signalosome (csn) complex modulators and uses thereof |
WO2019130313A1 (en) | 2017-12-28 | 2019-07-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method to reproduce circadian rhythms on a microfluidic chip |
WO2019145964A1 (en) | 2018-01-29 | 2019-08-01 | Yeda Research And Development Co. Ltd. | Combination of a mek inhibitor and a cdk4/6 inhibitor for the treatment of sarcoma |
WO2019150373A1 (en) | 2018-01-31 | 2019-08-08 | Yeda Research And Development Co. Ltd. | Endoplasmic reticulum targeting signal |
WO2019155465A1 (en) | 2018-02-08 | 2019-08-15 | Yeda Research And Development Co. Ltd. | Methods of identifying and using agents for treating diseases associated with intestinal barrier dysfunction |
WO2019155459A1 (en) | 2018-02-08 | 2019-08-15 | Yeda Research And Development Co. Ltd. | Inhibitors of the 20s proteasome |
US11571433B2 (en) | 2018-02-23 | 2023-02-07 | Carmel Haifa University Economic Corporation Ltd. | Methods for treating memory impairment and cognitive dysfunction |
WO2019167047A1 (en) | 2018-02-28 | 2019-09-06 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Methods of diagnosing and treating bladder cancer |
WO2019175869A1 (en) | 2018-03-12 | 2019-09-19 | Yeda Research And Development Co. Ltd | Treatment of a heart disease |
US11413336B2 (en) | 2018-03-23 | 2022-08-16 | Board Of Regents, The University Of Texas System | Coccidioides antigens and methods of their use |
WO2019186570A1 (en) | 2018-03-29 | 2019-10-03 | Yeda Research And Development Co. Ltd. | Methods of disrupting a biofilm and/or preventing formation of same |
US11648260B2 (en) | 2018-03-29 | 2023-05-16 | Technion Research And Development Foundation Limitted | Vesicles comprising a PTEN inhibitor and uses of same |
WO2019186569A1 (en) | 2018-03-29 | 2019-10-03 | Yeda Research And Development Co. Ltd. | Use of electric field gradients to control gene expression |
WO2019211750A1 (en) | 2018-05-01 | 2019-11-07 | Tropic Biosciences UK Limited | Compositions and methods for reducing caffeine content in coffee beans |
WO2019220437A1 (en) | 2018-05-15 | 2019-11-21 | Yeda Research And Development Co. Ltd. | Vaccination with cancer neoantigens |
WO2019220441A1 (en) | 2018-05-15 | 2019-11-21 | Hadasit Medical Research Services And Development Ltd. | Compositions and methods for treating cancer resistant to an anti-cancer agent |
WO2019229745A1 (en) | 2018-05-27 | 2019-12-05 | Biolinerx Ltd. | Agi-134 combined with a checkpoint inhibitor for the treatment of solid tumors |
WO2019234754A1 (en) | 2018-06-07 | 2019-12-12 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Nucleic acid constructs and methods of using same |
WO2019234750A1 (en) | 2018-06-07 | 2019-12-12 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Methods of regenerating and transforming cannabis |
WO2020003311A1 (en) | 2018-06-25 | 2020-01-02 | Yeda Research And Development Co. Ltd. | Systems and methods for increasing efficiency of genome editing |
WO2020008412A1 (en) | 2018-07-04 | 2020-01-09 | Ukko Inc. | Methods of de-epitoping wheat proteins and use of same for the treatment of celiac disease |
WO2020012467A2 (en) | 2018-07-08 | 2020-01-16 | Yeda Research And Development Co. Ltd. | Person-specific assessment of probiotics responsiveness |
WO2020012478A2 (en) | 2018-07-11 | 2020-01-16 | Immunity Pharma Ltd. | Peptide compounds and therapeutic uses of same |
WO2020012486A1 (en) | 2018-07-11 | 2020-01-16 | Kahr Medical Ltd. | SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF |
WO2020026241A1 (en) | 2018-07-31 | 2020-02-06 | Collplant Ltd. | Tobacco transgenic event and methods for detection and use thereof |
WO2020035863A1 (en) | 2018-08-14 | 2020-02-20 | Yeda Research And Development Co. Ltd. | Chimeric quiescin sulfhydryl oxidase (qsox1) antibodies and uses of same |
WO2020041360A1 (en) | 2018-08-21 | 2020-02-27 | Quidel Corporation | Dbpa antibodies and uses thereof |
WO2020039440A1 (en) | 2018-08-24 | 2020-02-27 | Yeda Research And Development Co. Ltd. | Methods of modulating m2 macrophage polarization and use of same in therapy |
WO2020058979A2 (en) | 2018-09-20 | 2020-03-26 | Yeda Research And Development Co. Ltd. | Methods of treating amyotrophic lateral sclerosis |
WO2020065647A1 (en) | 2018-09-25 | 2020-04-02 | Biolinerx Ltd. | Methods of selecting treatment for cxcr4-associated cancer |
WO2020089892A1 (en) | 2018-10-28 | 2020-05-07 | Yeda Research And Development Co. Ltd. | Prevention of age related clonal hematopoiesis and diseases associated therewith |
WO2020105050A2 (en) | 2018-11-21 | 2020-05-28 | Yeda Research And Development Co. Ltd. | Method of treating cancer and compositions for same |
WO2020132091A2 (en) | 2018-12-19 | 2020-06-25 | Humabs Biomed Sa | Antibodies that neutralize hepatitis b virus and uses thereof |
EP4292659A2 (en) | 2018-12-19 | 2023-12-20 | Humabs Biomed SA | Antibodies that neutralize hepatitis b virus and uses thereof |
WO2020152686A1 (en) | 2019-01-23 | 2020-07-30 | Yeda Research And Development Co. Ltd. | Culture media for pluripotent stem cells |
WO2020161724A1 (en) | 2019-02-10 | 2020-08-13 | Yeda Research And Development Co. Ltd. | Anti-matrix metalloproteinase 7 (mmp-7) inhibitory antibody and uses thereof |
WO2020165907A1 (en) | 2019-02-14 | 2020-08-20 | Yeda Research And Development Co. Ltd. | Spt5 inhibitors and uses thereof |
WO2020170240A1 (en) | 2019-02-21 | 2020-08-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method for reduction drug-induced nephrotoxicity |
WO2020170239A1 (en) | 2019-02-21 | 2020-08-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of generating organoids for high throughput screening of drugs |
WO2020178822A1 (en) | 2019-03-05 | 2020-09-10 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Genome-edited birds |
WO2020183419A1 (en) | 2019-03-14 | 2020-09-17 | Tropic Biosciences UK Limited | Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest |
WO2020183416A1 (en) | 2019-03-14 | 2020-09-17 | Tropic Biosciences UK Limited | PRODUCTION OF dsRNA IN PLANT CELLS FOR PEST PROTECTION VIA GENE SILENCING |
WO2020183414A2 (en) | 2019-03-14 | 2020-09-17 | Tropic Biosciences UK Limited | Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells |
WO2020188572A1 (en) | 2019-03-19 | 2020-09-24 | Yeda Research And Development Co. Ltd. | Bistable type ii opsins and uses thereof |
WO2020193718A1 (en) | 2019-03-27 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant proteins with cd40 activating properties |
WO2020194317A1 (en) | 2019-03-28 | 2020-10-01 | Yeda Research And Development Co. Ltd. | Method of treating lipid-related disorders |
WO2020202142A2 (en) | 2019-03-31 | 2020-10-08 | Yeda Research And Development Co. Ltd. | Anti-viral and anti-tumoral compounds |
WO2020222241A1 (en) | 2019-05-02 | 2020-11-05 | Yeda Research And Development Co. Ltd. | Compositions comprising the propeptide of lysyl oxidase and uses thereof |
WO2020230133A1 (en) | 2019-05-13 | 2020-11-19 | Yeda Research And Development Co. Ltd. | Cell-free mirna biomarkers for prognosis and diagnosis of neurodegenerative diseases |
WO2020234875A2 (en) | 2019-05-19 | 2020-11-26 | Yeda Research And Development Co. Ltd. | Identification of recurrent mutated neopeptides |
WO2020234888A1 (en) | 2019-05-22 | 2020-11-26 | Hadasit Medical Research Services And Development Ltd. | Methods of culturing human pluripotent cells |
WO2020237491A1 (en) | 2019-05-28 | 2020-12-03 | Shanghaitech University | Composition and methods to treat ectodermal dysplasia 2, clouston type |
WO2020250232A1 (en) | 2019-06-12 | 2020-12-17 | Hadasit Medical Research Services And Development Ltd. | Methods of generating oligodendrocytes |
WO2020255124A1 (en) | 2019-06-16 | 2020-12-24 | Yeda Research And Development Co. Ltd. | Method for stabilizing intracellular rna |
WO2020261281A1 (en) | 2019-06-27 | 2020-12-30 | Ramot At Tel-Aviv University Ltd. | Semaphorin 3a antibodies and uses thereof |
WO2021001784A1 (en) | 2019-07-04 | 2021-01-07 | Ukko Inc. | De-epitoped alpha gliadin and use of same for the management of celiac disease and gluten sensitivity |
WO2021005599A1 (en) | 2019-07-11 | 2021-01-14 | Kahr Medical Ltd. | Heterodimers and methods of use thereof |
WO2021009740A1 (en) | 2019-07-16 | 2021-01-21 | Ramot At Tel-Aviv University Ltd. | Compositions and methods for the treatment of tuberculosis |
WO2021009763A1 (en) | 2019-07-16 | 2021-01-21 | Yeda Research And Development Co. Ltd. | Methods of treating pain |
WO2021019526A1 (en) | 2019-07-29 | 2021-02-04 | Yeda Research And Development Co. Ltd. | Methods of treating and diagnosing lung cancer |
WO2021019536A1 (en) | 2019-07-30 | 2021-02-04 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby |
WO2021028909A1 (en) | 2019-08-12 | 2021-02-18 | Yeda Research And Development Co. Ltd. | Dna repair blood test for predicting response of lung cancer patients to immunotherapy |
WO2021033176A1 (en) | 2019-08-22 | 2021-02-25 | Ariel Scientific Innovations Ltd. | Scaled-up methods for purifying antibodies |
WO2021038569A1 (en) | 2019-08-27 | 2021-03-04 | Yeda Research And Development Co. Ltd. | Treatment of bacterial vaginosis |
WO2021042000A1 (en) | 2019-08-29 | 2021-03-04 | Vir Biotechnology, Inc. | Antibody compositions and methods for treating hepatitis b virus infection |
WO2021048852A1 (en) | 2019-09-11 | 2021-03-18 | Yeda Research And Development Co. Ltd. | Methods of treating breast cancer |
WO2021059269A1 (en) | 2019-09-25 | 2021-04-01 | Yeda Research And Development Co. Ltd. | Assembly of protein complexes on a chip |
WO2021084540A1 (en) | 2019-10-30 | 2021-05-06 | Yeda Research And Development Co. Ltd. | Inhibitors of mmej pathway for prevention and treatment of pre-myeloid and myeloid malignancies |
WO2021084526A1 (en) | 2019-10-31 | 2021-05-06 | Yeda Research And Development Co. Ltd. | Engineered autotrophic bacteria for co2 conversion to organic materials |
WO2021095031A2 (en) | 2019-11-11 | 2021-05-20 | Ibi-Ag Innovative Bio Insecticides Ltd. | Insect control nanobodies and uses thereof |
WO2021100034A1 (en) | 2019-11-19 | 2021-05-27 | Protalix Ltd. | Removal of constructs from transformed cells |
WO2021100041A1 (en) | 2019-11-20 | 2021-05-27 | Yeda Research And Development Co. Ltd. | Treating alzheimer's disease |
WO2021099576A1 (en) | 2019-11-21 | 2021-05-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Novel immunotherapies targeting pd-1 with anti-pd-1/il-15 immunocytokines |
WO2021110126A1 (en) | 2019-12-04 | 2021-06-10 | 珠海泰诺麦博生物技术有限公司 | Antibody against human cytomegalovirus and use thereof |
WO2021130752A1 (en) | 2019-12-22 | 2021-07-01 | Yeda Research And Development Co. Ltd. | Systems and methods for identifying cells that have undergone genome editing |
WO2021130753A1 (en) | 2019-12-22 | 2021-07-01 | Yeda Research And Development Co. Ltd. | Diagnosis of frontotemporal dementia |
WO2021137231A1 (en) | 2019-12-31 | 2021-07-08 | Kahr Medical Ltd. | Methods of culturing t cells with a 4-1bbl fusion polypeptide and uses of same |
WO2021137222A1 (en) | 2019-12-31 | 2021-07-08 | Ichilov Tech Ltd. | Methods of treating atopic dermatitis |
WO2021137230A1 (en) | 2019-12-31 | 2021-07-08 | Kahr Medical Ltd. | Methods of culturing t cells and uses of same |
WO2021144798A1 (en) | 2020-01-15 | 2021-07-22 | Immunity Pharma Ltd. | Peptide compounds and methods of treating diseases using same |
WO2021149053A1 (en) | 2020-01-22 | 2021-07-29 | Yeda Research And Development Co. Ltd. | Multispecific antibodies for use in treating diseases |
WO2021152584A1 (en) | 2020-01-28 | 2021-08-05 | Ariel Scientific Innovations Ltd. | Methods of analyzing cell membranes |
WO2021152587A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Treating acute liver disease with tlr-mik inhibitors |
WO2021152590A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Articles of manufacture comprising anti pd-l1 antibodies and their use in therapy |
WO2021152592A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Methods of treating cancer |
WO2021152586A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Methods of analyzing microbiome, immunoglobulin profile and physiological state |
WO2021156878A2 (en) | 2020-02-09 | 2021-08-12 | Nlc Pharma Ltd | Rapid detection test for sars-cov-2 |
WO2021161310A1 (en) | 2020-02-10 | 2021-08-19 | Yeda Research And Development Co. Ltd. | Method for analyzing cell clusters |
WO2021173674A1 (en) | 2020-02-26 | 2021-09-02 | A2 Biotherapeutics, Inc. | Polypeptides targeting mage-a3 peptide-mhc complexes and methods of use thereof |
WO2021178637A1 (en) | 2020-03-05 | 2021-09-10 | Iowa State University Research Foundation, Inc. | IMMUNOGENIC AND VACCINE COMPOSITIONS AGAINST SARS-CoV-2 |
WO2021186431A1 (en) | 2020-03-16 | 2021-09-23 | Yeda Research And Development Co. Ltd. | Peptide analogs and use of same in treating diseases, disorders or conditions associated with a mutant p53 protein |
WO2021199039A1 (en) | 2020-03-29 | 2021-10-07 | Yeda Research And Development Co. Ltd. | Variants of beta-glucocerebrosidase for use in treating gaucher disease |
WO2021199047A1 (en) | 2020-03-31 | 2021-10-07 | Biomuse Ltd. | Bacteria for the prevention and treatment of smoke-induced lung damage |
WO2021205444A1 (en) | 2020-04-06 | 2021-10-14 | Yeda Research And Development Co. Ltd. | Methods of diagnosing cancer and predicting responsiveness to therapy |
WO2021205459A1 (en) | 2020-04-07 | 2021-10-14 | Ramot At Tel-Aviv University Ltd. | Cannabidiol-containing compositions and uses thereof |
WO2021209995A1 (en) | 2020-04-13 | 2021-10-21 | Exoprother Medical Ltd. | Cell-derived vesicles comprising wild-type p53 protein for antiviral therapy |
EP3895697A1 (en) | 2020-04-16 | 2021-10-20 | Ichilov Tech Ltd. | Cell-derived particles presenting heterologous cd24 and use thereof in therapy |
WO2021210002A1 (en) | 2020-04-16 | 2021-10-21 | Ichilov Tech Ltd. | Cell-derived particles presenting heterologous cd24 and use thereof in therapy |
WO2021229577A1 (en) | 2020-05-12 | 2021-11-18 | Collplant Ltd. | Collagen as a delivery tool for metal-based anti-viral agents |
WO2021228836A1 (en) | 2020-05-13 | 2021-11-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant proteins with ox40 activating properties |
WO2021234698A1 (en) | 2020-05-20 | 2021-11-25 | Yeda Research And Development Co. Ltd. | Indexing spatial information for a single-cell downstream applications |
WO2021260675A1 (en) | 2020-06-24 | 2021-12-30 | Yeda Research And Development Co. Ltd. | Agents for sensitizing solid tumors to treatment |
WO2021262840A1 (en) | 2020-06-24 | 2021-12-30 | Vir Biotechnology, Inc. | Engineered hepatitis b virus neutralizing antibodies and uses thereof |
WO2022034575A1 (en) | 2020-08-09 | 2022-02-17 | Yeda Research And Development Co. Ltd. | Mage-a1 specific t cell receptor and uses thereof |
WO2022034588A1 (en) | 2020-08-10 | 2022-02-17 | Yeda Research And Development Co. Ltd. | Compositions for diagnosis and treatment of coronavirus infections |
WO2022038536A1 (en) | 2020-08-18 | 2022-02-24 | International Rice Research Institute | Methods of increasing outcrossing rates in gramineae |
WO2022059015A1 (en) | 2020-09-21 | 2022-03-24 | Yeda Research And Development Co. Ltd. | Method for modulating weight |
WO2022064494A2 (en) | 2020-09-23 | 2022-03-31 | Yeda Research And Development Co. Ltd. | Methods and compositions for treating coronaviral infections |
WO2022070194A1 (en) | 2020-10-01 | 2022-04-07 | Yeda Research And Development Co. Ltd. | Method of diagnosing breast cancer |
WO2022074646A1 (en) | 2020-10-05 | 2022-04-14 | Protalix Ltd. | Dicer-like knock-out plant cells |
WO2022074656A1 (en) | 2020-10-07 | 2022-04-14 | Protalix Ltd. | Long-acting dnase |
WO2022079719A1 (en) | 2020-10-15 | 2022-04-21 | Yeda Research And Development Co. Ltd. | Method of treating myeloid malignancies |
WO2022091100A1 (en) | 2020-10-29 | 2022-05-05 | Yeda Research And Development Co. Ltd. | Polynucleotides for rna editing and methods of using same |
WO2022097157A2 (en) | 2020-11-09 | 2022-05-12 | 1E Therapeutics, Ltd. | Catalytic sequence based methods of treating or preventing bacterial infections |
WO2022115498A1 (en) | 2020-11-26 | 2022-06-02 | Ukko Inc. | Modified high molecular weight glutenin subunit and uses thereof |
WO2022130384A1 (en) | 2020-12-17 | 2022-06-23 | Yeda Research And Development Co. Ltd. | Controlling ubiquitination of mlkl for treatment of disease |
US11879140B2 (en) | 2020-12-28 | 2024-01-23 | 1E Therapeutics Ltd. | P21 mRNA targeting DNAzymes |
WO2022144883A2 (en) | 2020-12-28 | 2022-07-07 | 1E Therapeutics, Ltd. | P21 mrna targeting dnazymes |
WO2022144882A2 (en) | 2020-12-28 | 2022-07-07 | 1E Therapeutics, Ltd. | P21 mrna target areas for silencing |
WO2022149142A2 (en) | 2021-01-10 | 2022-07-14 | Supermeat The Essence Of Meat Ltd. | Pluripotent stem cell aggregates and microtissues obtained therefrom for the cultured meat industry |
WO2022153286A1 (en) | 2021-01-14 | 2022-07-21 | Yeda Research And Development Co. Ltd. | Methods of producing vitamin d |
WO2022157774A1 (en) | 2021-01-21 | 2022-07-28 | Yeda Research And Development Co. Ltd. | Antibodies, peptides and combinations of same for the treatment or prevention of coronavirus infection |
WO2022164805A1 (en) | 2021-01-26 | 2022-08-04 | Vir Biotechnology, Inc. | Compositions and methods for treating hepatitis b virus infection |
WO2022175952A1 (en) | 2021-02-18 | 2022-08-25 | Yeda Research And Development Co. Ltd. | Method of generating vaccines |
WO2022175951A1 (en) | 2021-02-18 | 2022-08-25 | Yeda Research And Development Co. Ltd. | Genetically modified bacteria for generating vaccines |
WO2022189558A2 (en) | 2021-03-10 | 2022-09-15 | Mabylon Ag | Antibodies against tdp-43 and methods of using the same |
WO2022195589A2 (en) | 2021-03-16 | 2022-09-22 | Yeda Research And Development Co. Ltd. | Methods and devices for ex-utero mouse embryonic development |
US11957734B2 (en) | 2021-03-25 | 2024-04-16 | Baylor Research Institute | Methods and compositions for treating autoimmune and inflammatory conditions |
WO2022208369A1 (en) | 2021-03-30 | 2022-10-06 | Biomx Ltd. | Pseudomonas bacteriophage and uses thereof |
WO2022215080A1 (en) | 2021-04-08 | 2022-10-13 | Yeda Research And Development Co. Ltd. | A combined use of ketamine and retigabine (ezogabine) for the treatment of psychiatric disorders |
WO2022238947A1 (en) | 2021-05-12 | 2022-11-17 | Biomx Ltd. | Staphylococcus bacteriophage and uses thereof |
WO2022254430A1 (en) | 2021-05-30 | 2022-12-08 | Yeda Research And Development Co. Ltd. | Anti-microbial peptide (amp) signatures for diagnostics, stratification, and treatment of microbiome-associated disease |
WO2022259242A1 (en) | 2021-06-06 | 2022-12-15 | Yeda Research And Development Co. Ltd. | Combined treatment for cancer |
WO2022264132A1 (en) | 2021-06-13 | 2022-12-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method for reprogramming human cells |
NL2028466B1 (en) | 2021-06-16 | 2022-12-21 | Sakata Holland B V | Methods of sorting matthiola seeds |
WO2022264076A1 (en) | 2021-06-16 | 2022-12-22 | Seedx Technologies Inc. | Methods of sorting matthiola seeds |
WO2023275255A1 (en) | 2021-07-02 | 2023-01-05 | Tropic Biosciences UK Limited | Delay or prevention of browning in banana fruit |
WO2023003809A1 (en) | 2021-07-18 | 2023-01-26 | Gamida-Cell Ltd. | Therapeutic nk cell populations |
WO2023002492A1 (en) | 2021-07-22 | 2023-01-26 | Yeda Research And Development Co. Ltd. | Codon optimization of nucleic acids |
EP4130028A1 (en) | 2021-08-03 | 2023-02-08 | Rhazes Therapeutics Ltd | Engineered tcr complex and methods of using same |
WO2023012584A2 (en) | 2021-08-03 | 2023-02-09 | Genicity Limited | Engineered tcr complex and methods of using same |
WO2023018621A1 (en) | 2021-08-10 | 2023-02-16 | Gamida-Cell Ltd. | Engineered nk cells, methods of their production and uses thereof |
GB202112865D0 (en) | 2021-09-09 | 2021-10-27 | Tropic Biosciences Uk Ltd | Resistance to black sigatoka disease in banana |
GB202112866D0 (en) | 2021-09-09 | 2021-10-27 | Tropic Biosciences Uk Ltd | Resistance to fusarium wilt in a banana |
WO2023042202A1 (en) | 2021-09-14 | 2023-03-23 | Yeda Research And Development Co. Ltd. | Multispecific antibodies for use in treating diseases |
WO2023105526A1 (en) | 2021-12-08 | 2023-06-15 | Yeda Research And Development Co. Ltd. | Multipotent lung progenitor cells for lung regeneration |
WO2023144779A1 (en) | 2022-01-28 | 2023-08-03 | Pfizer Inc. | Coronavirus antigen variants |
WO2023209708A1 (en) | 2022-04-25 | 2023-11-02 | Yeda Research And Development Co. Ltd. | Compositions for altering cyclic adp-ribose secondary messenger signalling |
WO2023242155A1 (en) | 2022-06-14 | 2023-12-21 | Janssen Vaccines & Prevention B.V. | Compositions and methods for the diagnosis of hiv infection |
Also Published As
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GB1363565A (en) | 1974-08-14 |
DK150170C (en) | 1987-06-29 |
BR7200729D0 (en) | 1973-10-25 |
DK150170B (en) | 1986-12-22 |
DE2206103B2 (en) | 1975-10-16 |
DE2206103A1 (en) | 1972-08-24 |
FI53894C (en) | 1978-08-10 |
ES399608A1 (en) | 1974-11-16 |
CA1040082B (en) | 1978-10-10 |
SE451098B (en) | 1987-08-31 |
CH573115A5 (en) | 1976-02-27 |
NL7101728A (en) | 1972-08-14 |
BE779209A (en) | 1972-05-30 |
FI53894B (en) | 1978-05-02 |
AU3855272A (en) | 1973-08-09 |
JPS5247011B1 (en) | 1977-11-29 |
CA958314A (en) | 1974-11-26 |
FR2126760A5 (en) | 1972-10-06 |
ZA72548B (en) | 1972-10-25 |
NL154600B (en) | 1977-09-15 |
AU468151B2 (en) | 1973-08-09 |
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